CN114917320A - Oral bacteriostatic spray synthesized by panax notoginseng saponins and tea polyphenol - Google Patents

Oral bacteriostatic spray synthesized by panax notoginseng saponins and tea polyphenol Download PDF

Info

Publication number
CN114917320A
CN114917320A CN202210401623.4A CN202210401623A CN114917320A CN 114917320 A CN114917320 A CN 114917320A CN 202210401623 A CN202210401623 A CN 202210401623A CN 114917320 A CN114917320 A CN 114917320A
Authority
CN
China
Prior art keywords
parts
panax notoginseng
tea polyphenol
notoginseng saponins
synthesized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202210401623.4A
Other languages
Chinese (zh)
Inventor
刘长坤
方波
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chongqing Gongcun Technology Co ltd
Original Assignee
Chongqing Gongcun Technology Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chongqing Gongcun Technology Co ltd filed Critical Chongqing Gongcun Technology Co ltd
Priority to CN202210401623.4A priority Critical patent/CN114917320A/en
Publication of CN114917320A publication Critical patent/CN114917320A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A61K31/015—Hydrocarbons carbocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A61K38/063—Glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Toxicology (AREA)
  • Botany (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention provides an oral bacteriostatic spray synthesized by panax notoginseng saponins and tea polyphenol, and relates to the field of medical treatment. The oral bacteriostatic spray based on the synthesis of the panax notoginseng saponins and the tea polyphenol comprises the following components in parts by weight: 3-4 parts of panax notoginseng saponins, 1-1.5 parts of tea polyphenol, 2-4 parts of chloroacetidine acetate, 1-1.5 parts of carotenoid, 1-1.5 parts of glutathione and 87.5-92 parts of purified water. The panax notoginseng saponins and the acetochlor have lasting and obvious analgesic effect, can improve physique, can effectively stop bleeding, can obviously shorten bleeding and blood coagulation time, has obvious analgesic effect and antibacterial effect, and simultaneously effectively activates the ion channel protein of KCNQ5 in a special type to diffuse potassium ions out of cells so as to reduce the excitability of the cells and relax blood vessels, thereby reducing blood pressure and stopping bleeding together with the panax notoginseng saponins.

Description

Oral bacteriostatic spray synthesized by panax notoginseng saponins and tea polyphenol
Technical Field
The invention relates to the technical field of medical treatment, in particular to an oral bacteriostatic spray synthesized by panax notoginseng saponins and tea polyphenol.
Background
The oral bacteriostatic spray is an anti-inflammatory drug. The oral anti-inflammatory spray has the effects of clearing heat and removing toxicity, diminishing inflammation and relieving pain, and has the effects on oral inflammation, throat inflammation, gingival inflammation, oral ulcer and the like. The application method is simple, and the medicine can be applied to the affected part for a period of about half an hour without gargling and drinking water after administration. Meanwhile, the diet is mainly light and does not need to eat spicy stimulating food, so that the recovery can be effectively helped.
Disclosure of Invention
Technical problem to be solved
Aiming at the defects of the prior art, the invention provides an oral bacteriostatic spray synthesized by panax notoginseng saponins and tea polyphenol, which solves the problems of long bleeding time and slow blood coagulation.
(II) technical scheme
In order to achieve the purpose, the invention is realized by the following technical scheme: the oral bacteriostatic spray synthesized by the panax notoginseng saponins and the tea polyphenol comprises the following components in parts by weight: 3-4 parts of panax notoginseng saponins, 1-1.5 parts of tea polyphenol, 2-4 parts of chloroacetidine acetate, 1-1.5 parts of carotenoid, 1-1.5 parts of glutathione and 87.5-92 parts of purified water.
Preferably, the tea polyphenol comprises epigallocatechin gallate, epicatechin gallate, epigallocatechin and epicatechin, and the compositions of the epigallocatechin gallate, the epicatechin gallate, the epigallocatechin and the epicatechin are 5:2:2: 1.
Preferably, the panax notoginseng saponins contain steroid saponin, triterpene saponin, protein, vitamin and polysaccharide.
Preferably, the purified water is water with secondary reverse osmosis membrane filtration conductivity less than or equal to 0.5.
Preferably, the composition consists of the following components in parts by weight: 3 parts of panax notoginseng saponins, 1 part of tea polyphenol, 2 parts of chloroacetidine acetate, 1 part of carotenoid, 1 part of glutathione and 92 parts of purified water.
Preferably, the composition consists of the following components in parts by weight: 4 parts of panax notoginseng saponins, 1.5 parts of tea polyphenol, 4 parts of acetochloracetin, 1.5 parts of carotenoid, 1.5 parts of glutathione and 87.5 parts of purified water.
Preferably, the composition consists of the following components in parts by weight: 3.5 parts of panax notoginseng saponins, 1.25 parts of tea polyphenol, 3 parts of acetochlor, 1.25 parts of carotenoid, 1.25 parts of glutathione and 90.75 parts of purified water.
Preferably, the method comprises the following preparation steps:
s1, selecting panax notoginseng saponins with corresponding components and purified water, fully mixing the panax notoginseng saponins and the purified water in a mixing device, and melting at 121 ℃ under high pressure MP after mixing;
s2, placing the mixture in a sterile and dustless environment, and standing and cooling the mixture to 25 ℃;
s3, introducing the tea polyphenol into the mixture, and then adding the chloroacetidine acetate, the carotenoid and the glutathione to fully mix.
(III) advantageous effects
The invention provides an oral bacteriostatic spray synthesized by panax notoginseng saponins and tea polyphenol. The method has the following beneficial effects:
1. the panax notoginseng saponins and the chloroacetidine acetate have lasting and obvious pain relieving effect, can improve physique, can effectively stop bleeding, can obviously shorten bleeding and blood coagulation time, has obvious pain relieving effect and simultaneously has antibacterial effect.
2. The synergistic effect of the tea polyphenol, the carotenoid and the glutathione enhances the antioxidant effect of the tea polyphenol, and simultaneously effectively activates the special type ion channel protein of KCNQ5, so that potassium ions diffuse out of cells, blood vessels are dilated, the blood pressure is reduced, and the blood is stopped together with the panax notoginseng saponins.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be obtained by a person skilled in the art without making any creative effort based on the embodiments in the present invention, belong to the protection scope of the present invention.
The first embodiment is as follows:
the embodiment of the invention provides an oral bacteriostatic spray synthesized by panax notoginseng saponins and tea polyphenol, which consists of the following components in parts by weight: the panax notoginseng saponins contain steroid saponin, triterpenoid saponin, protein, vitamin and polysaccharide inside, the purified water is water with the secondary reverse osmosis membrane filtration conductivity of less than or equal to 0.5, the panax notoginseng saponins have the effects of inhibiting platelet aggregation and increasing cerebral blood flow, have the effects of stopping bleeding, obviously shortening bleeding and blood coagulation time, promoting division and growth of human erythrocytes, and obviously enriching blood, have lasting and obvious pain relieving effect, and have obvious pain relieving effect on pain caused by chemical and thermal stimulation, and the tea polyphenols comprise epigallocatechin gallate, epicatechin gallate, epigallocatechin gallate, epicatechin gallate, epigallocatechin gallate, etc, Epigallocatechin and epicatechin have the components of 5:2:2:1, tea polyphenol has multiple physiological activities of resisting oxidation, preventing radiation, resisting aging, reducing blood fat, reducing blood sugar, inhibiting bacteria and enzyme and the like, the synergistic effect of carotenoid and glutathione enhances the antioxidant effect of the tea polyphenol, epicatechin gallate ECG and epicatechin-3-gallate EGCG activate a special type of ion channel protein named KCNQ5, so that potassium ions diffuse out of cells to reduce the excitability of the cells and relax blood vessels, thereby reducing blood pressure, more effectively activating KCNQ5 at 35 ℃, and activating beneficial pressure reducing characteristics at the temperature of a human body of about 37 ℃.
The preparation method comprises the following preparation steps:
s1, selecting panax notoginseng saponins with corresponding components and purified water, fully mixing the panax notoginseng saponins and the purified water in a mixing device, and melting at 121 ℃ under high pressure MP after mixing;
s2, placing the mixture in a sterile and dustless environment, and standing and cooling the mixture to 25 ℃;
s3, introducing the tea polyphenol into the mixture, and then adding the chloroacetidine acetate, the carotenoid and the glutathione to fully mix.
Example two:
the embodiment of the invention provides an oral bacteriostatic spray synthesized by panax notoginseng saponins and tea polyphenol, which consists of the following components in parts by weight: 4 parts of panax notoginseng saponins, 1.5 parts of tea polyphenol, 4 parts of acetochlor, 1.5 parts of carotenoid, 1.5 parts of glutathione and 87.5 parts of purified water, wherein the panax notoginseng saponins contain steroid saponin, triterpene saponin, protein, vitamin and polysaccharide, the purified water is water with the secondary reverse osmosis membrane filtration conductivity of less than or equal to 0.5, the panax notoginseng saponins have the effects of inhibiting platelet aggregation and increasing cerebral blood flow, have the effects of stopping bleeding, obviously shortening bleeding and blood coagulation time, promoting division and growth of human erythrocytes, obviously enriching blood, have lasting and obvious analgesic effect, and also have obvious analgesic effect on pain caused by chemical and thermal irritation, and the tea polyphenol comprises epigallocatechin gallate, epicatechin gallate, epigallocatechin, epicatechin gallate, epicatechin gallate and epicatechin gallate, Epigallocatechin and epicatechin have the components of 5:2:2:1, tea polyphenol has multiple physiological activities of resisting oxidation, preventing radiation, resisting aging, reducing blood fat, reducing blood sugar, inhibiting bacteria and enzyme and the like, the synergistic effect of carotenoid and glutathione enhances the antioxidant effect of the tea polyphenol, epicatechin gallate ECG and epicatechin-3-gallate EGCG activate a special type of ion channel protein named KCNQ5, so that potassium ions diffuse out of cells to reduce the excitability of the cells and relax blood vessels, thereby reducing blood pressure, more effectively activating KCNQ5 at 35 ℃, and activating beneficial pressure reducing characteristics at the temperature of a human body of about 37 ℃.
The preparation method comprises the following preparation steps:
s1, selecting panax notoginseng saponins with corresponding components and purified water, fully mixing the panax notoginseng saponins and the purified water in a mixing device, and melting at 121 ℃ under high pressure MP after mixing;
s2, placing the mixture in a sterile and dustless environment, and standing and cooling the mixture to 25 ℃;
s3, introducing the tea polyphenol into the mixture, and then adding the chloroacetidine acetate, the carotenoid and the glutathione to fully mix.
Example three:
the embodiment of the invention provides an oral bacteriostatic spray synthesized by panax notoginseng saponins and tea polyphenol, which consists of the following components in parts by weight: 3.5 parts of panax notoginseng saponins, 1.25 parts of tea polyphenol, 3 parts of chloroacetidine acetate, 1.25 parts of carotenoid, 1.25 parts of glutathione and 90.75 parts of purified water, wherein the panax notoginseng saponins contain steroid saponin, triterpenoid saponin, protein, vitamin and polysaccharide, the purified water is water with the secondary reverse osmosis membrane filtration conductivity of less than or equal to 0.5, the panax notoginseng saponins have the effects of inhibiting platelet aggregation and increasing cerebral blood flow, have the effects of stopping bleeding, obviously shortening bleeding and blood coagulation time, promoting division and growth of human erythrocytes, obviously tonifying blood, have lasting and obvious pain relieving effect and also have obvious pain relieving effect on pain caused by chemical and thermal stimulation, and the tea polyphenol comprises epigallocatechin gallate, epicatechin gallate, epigallocatechin, epicatechin gallate, epigallocatechin gallate and epigallocatechin gallate, Epigallocatechin and epicatechin have the components of 5:2:2:1, tea polyphenol has multiple physiological activities of resisting oxidation, preventing radiation, resisting aging, reducing blood fat, reducing blood sugar, inhibiting bacteria and enzyme and the like, the synergistic effect of carotenoid and glutathione enhances the antioxidant effect of the tea polyphenol, epicatechin gallate ECG and epicatechin-3-gallate EGCG activate a special type of ion channel protein named KCNQ5, so that potassium ions diffuse out of cells to reduce the excitability of the cells and relax blood vessels, thereby reducing blood pressure, more effectively activating KCNQ5 at 35 ℃, and activating beneficial pressure reducing characteristics at the temperature of a human body of about 37 ℃.
The preparation method comprises the following preparation steps:
s1, selecting panax notoginseng saponins with corresponding components and purified water, fully mixing the panax notoginseng saponins and the purified water in a mixing device, and melting at 121 ℃ under high pressure MP after mixing;
s2, placing the mixture in a sterile and dustless environment, and standing and cooling the mixture to 25 ℃;
s3, introducing the tea polyphenol into the mixture, and then adding the chloroacetidine acetate, the carotenoid and the glutathione to fully mix.
Pharmaceutical composition Patient condition Residence time of drug
Example one The oral bleeding is less than 1 ml, and the inflammation area is less than 1 square centimeter 2min
Example two The oral bleeding is more than 2 ml, the inflammation area is more than 3 square centimeters 5min
EXAMPLE III 1-2 ml of oral bleeding and 1-3 square centimeters of inflammation area 3min
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims (8)

1. An oral bacteriostatic spray synthesized by panax notoginseng saponins and tea polyphenol is characterized in that: the coating comprises the following components in parts by weight: 3-4 parts of panax notoginseng saponins, 1-1.5 parts of tea polyphenol, 2-4 parts of chloroacetidine acetate, 1-1.5 parts of carotenoid, 1-1.5 parts of glutathione and 87.5-92 parts of purified water.
2. The oral bacteriostatic spray synthesized by panax notoginseng saponins and tea polyphenol according to claim 1, which is characterized in that: the tea polyphenols comprise epigallocatechin gallate, epicatechin gallate, epigallocatechin and epicatechin, and the compositions of epigallocatechin gallate, epicatechin gallate, epigallocatechin and epicatechin are 5:2:2: 1.
3. The oral bacteriostatic spray synthesized by panax notoginseng saponins and tea polyphenol according to claim 1, which is characterized in that: the total saponins of Notoginseng radix contain steroid saponin, triterpene saponin, protein, vitamin, and polysaccharide.
4. The oral bacteriostatic spray synthesized by panax notoginseng saponins and tea polyphenol according to claim 1, which is characterized in that: the purified water is water with the secondary reverse osmosis membrane filtration conductivity less than or equal to 0.5.
5. The oral bacteriostatic spray synthesized by panax notoginseng saponins and tea polyphenol according to claim 1, which is characterized in that: the composition comprises the following components in parts by weight: 3 parts of panax notoginseng saponins, 1 part of tea polyphenol, 2 parts of chloroacetidine acetate, 1 part of carotenoid, 1 part of glutathione and 92 parts of purified water.
6. The oral bacteriostatic spray synthesized by panax notoginseng saponins and tea polyphenol according to claim 1, which is characterized in that: the composition comprises the following components in parts by weight: 4 parts of panax notoginseng saponins, 1.5 parts of tea polyphenol, 4 parts of acetochloracetin, 1.5 parts of carotenoid, 1.5 parts of glutathione and 87.5 parts of purified water.
7. The oral bacteriostatic spray synthesized by panax notoginseng saponins and tea polyphenol according to claim 1, which is characterized in that: the composition comprises the following components in parts by weight: 3.5 parts of panax notoginseng saponins, 1.25 parts of tea polyphenol, 3 parts of acetochlor, 1.25 parts of carotenoid, 1.25 parts of glutathione and 90.75 parts of purified water.
8. The oral bacteriostatic spray synthesized by panax notoginseng saponins and tea polyphenol according to claim 1, which is characterized in that: the preparation method comprises the following preparation steps:
s1, selecting panax notoginseng saponins with corresponding components and purified water, fully mixing the panax notoginseng saponins and the purified water in a mixing device, and melting at 121 ℃ under high pressure MP after mixing;
s2, placing the mixture in a sterile and dustless environment, and standing and cooling the mixture to 25 ℃;
s3, introducing the tea polyphenol into the mixture, and then adding the chloroacetidine acetate, the carotenoid and the glutathione to fully mix.
CN202210401623.4A 2022-04-18 2022-04-18 Oral bacteriostatic spray synthesized by panax notoginseng saponins and tea polyphenol Pending CN114917320A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202210401623.4A CN114917320A (en) 2022-04-18 2022-04-18 Oral bacteriostatic spray synthesized by panax notoginseng saponins and tea polyphenol

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202210401623.4A CN114917320A (en) 2022-04-18 2022-04-18 Oral bacteriostatic spray synthesized by panax notoginseng saponins and tea polyphenol

Publications (1)

Publication Number Publication Date
CN114917320A true CN114917320A (en) 2022-08-19

Family

ID=82807508

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202210401623.4A Pending CN114917320A (en) 2022-04-18 2022-04-18 Oral bacteriostatic spray synthesized by panax notoginseng saponins and tea polyphenol

Country Status (1)

Country Link
CN (1) CN114917320A (en)

Similar Documents

Publication Publication Date Title
EP3342418A1 (en) Acne removing skin care product and preparation method thereof
CN109331095B (en) Composition for eliminating eczema and preparation method thereof
CN108272862B (en) Pudilan oral spray and preparation method thereof
EP3342419B1 (en) Acne-removing traditional chinese medicine composition and preparation method thereof
CN109010174B (en) Composition and eczema cream containing same
CN111228207B (en) Dampness-rash-eliminating hip-protecting cream and preparation method thereof
CN111821355A (en) Eyesight-protecting lycium ruthenicum and lutein chewable tablet and preparation method thereof
CN109620879A (en) A kind of wet repairing paste and preparation method thereof clearly
CN105125467A (en) Emulsion removing red blood and preparing method of emulsion
CN114917320A (en) Oral bacteriostatic spray synthesized by panax notoginseng saponins and tea polyphenol
Gupta et al. Sea Buckthorn (Hippophae rhamnoides L.) Seed oil: usage in burns, ulcers, and mucosal injuries
CN111110833A (en) A skin caring composition for oral administration and topical application, and its preparation method
CN111035610A (en) Weight-losing milk containing theanine and preparation method thereof
CN107158051B (en) Tannic acid ointment for treating eczema and preparation method thereof
CN105748545B (en) Application of Notoginseng radix converted saponin in preparing medicine for resisting fungi such as Epidermophyton floccosum, Trichophyton rubrum and Trichophyton mentagrophytes
CN103417815A (en) Traditional Chinese medicine effective part composition for treating hemorrhagic stroke, and preparation method of same
CN105031170A (en) Healthcare foot bath powder and preparing method thereof
CN110812377A (en) Acne treatment and repair composition and application thereof
CN115120690B (en) Traditional Chinese medicine composition for treating precocious puberty and application thereof
CN114053286B (en) Pharmaceutical composition and preparation method and application thereof
CN115414427B (en) Traditional Chinese medicine composition for treating chronic skin pruritus and preparation method and application thereof
CN104740140A (en) Nursing medicament for treating burns and scalds
CN117503695A (en) Ointment for treating stomatitis and preparation method thereof
CN105031223A (en) Chinese and western medicine compound preparation for treating eczema of external ear
CN114788572A (en) Composition for prolonging life and beautifying

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination