CN111821355A

CN111821355A - Eyesight-protecting lycium ruthenicum and lutein chewable tablet and preparation method thereof

Info

Publication number: CN111821355A
Application number: CN202010785381.4A
Authority: CN
Inventors: 谢晓亮; 贾东升; 温春秀; 魏曼; 崔施展; 刘永进
Original assignee: Hebei Kangping Health Industry Co ltd
Current assignee: Hebei Kangping Health Industry Co ltd
Priority date: 2020-08-06
Filing date: 2020-08-06
Publication date: 2020-10-27

Abstract

The invention provides a black wolfberry lutein chewable tablet for protecting eyesight, which comprises the following raw materials in parts by weight: 15-20 parts of black wolfberry, 15-20 parts of mulberry, 10-15 parts of cowberry fruit, 15-20 parts of cassia seed, 10-15 parts of kudzu root, 10-15 parts of chrysanthemum, 10-15 parts of wolfberry, 2 parts of lutein, 0.1 part of vitamin C, 0.05 part of vitamin A and 0.05 part of beta-carotene. The medicinal and edible plant composition has the advantages of being multiple in raw materials for protecting eyesight and relieving asthenopia, complex in extraction and purification process, capable of protecting eyesight, relieving asthenopia, preventing ultraviolet ray from damaging eyes, preventing macular degeneration of retina of eyes and promoting proliferation of visual red blood cells, and also capable of resisting oxidation, clearing liver and improving eyesight, improving immunity and the like.

Description

Eyesight-protecting lycium ruthenicum and lutein chewable tablet and preparation method thereof

Technical Field

The invention relates to the field of medicinal materials, in particular to a black wolfberry lutein chewable tablet for protecting eyesight and a preparation method thereof.

Background

Eye fatigue becomes a common disease of contemporary people, and dry eyes, sour eyes, swollen eyes, blurred vision and even visual deterioration caused by the eye fatigue directly influence the work and life of people. The eyestrain is mainly caused by that people watch the screens of computers, televisions and mobile phones for a long time, the number of blinking is reduced, tear secretion is correspondingly reduced, and rays and radiation harm are caused. Young people in the multi-screen age are often in a tension state of over-fatigue of eyes, and unclear vision, myopia, dryness and swelling become common phenomena and are important manifestations of eye sub-health. The development of a product with the effects of protecting eyesight and providing eye nutrition has very important practical significance, and can help a user to enhance eye nutrition, protect eyesight and relieve eye fatigue.

The Chinese invention patent publication No. CN107519338A, entitled "a Chinese medicinal composition for protecting eyesight by external use", specifically discloses that the Chinese medicinal composition comprises the following raw material medicaments: the external application of the externally applied medicine on the periphery of eye sockets is matched with a physical therapy instrument, and the clinically detected medicine has obvious curative effects on visual fatigue symptoms such as visual disturbance, eye drowsiness, photophobia, ache, lacrimation, foreign body sensation, dry eye, eye spasm and the like.

The traditional Chinese medicine composition is prepared from a plurality of raw materials, mainly aiming at external stimulation, and is complex to prepare and produce, and the obtained traditional Chinese medicine composition has a single function, only has a simple external stimulation effect applied to eyes to relieve symptoms, and cannot provide nutrition for the eyes from the mechanism; the effects of protecting eyesight, providing eye nutrition and relieving eye fatigue can not be achieved by oral administration and mechanically regulating and controlling various active ingredients; the raw materials and mechanisms adopted by external application and oral administration are completely different. The invention takes orally, leads active substances to participate in the physiological metabolism of eye cells, and achieves the effects of protecting vision, relieving asthenopia, preventing ultraviolet rays from damaging eyes, preventing macular degeneration of the retina of the eyes, promoting the proliferation of erythrocyte, resisting oxidation, clearing liver and improving vision, improving immunity and the like.

Disclosure of Invention

The invention utilizes the lutein as the main component of the macula lutea in eyes, can prevent the aging of the macula lutea, has the filtering function on ultraviolet rays, and can prevent and treat the damage of the ultraviolet rays to the eyes and the vision. Radix Puerariae and flos Chrysanthemi are combined for clearing liver-fire, improving eyesight, relieving asthenopia and reducing blood lipid. The black wolfberry, the mulberry and the cowberry fruit contain rich anthocyanin, protect capillary vessels, increase the regeneration of visual red cells, effectively protect eyes and eyesight and prevent and treat the damage of ultraviolet rays to the eyes. The lycium barbarum polysaccharide has stronger biological activity, is easy to absorb and utilize, and has better effects of reducing high blood pressure, high blood sugar, high blood lipid, high blood pressure, high blood sugar, high blood fat, high blood.

In order to achieve the purpose, the invention is realized by the following technical scheme:

the black wolfberry lutein chewable tablet for protecting eyesight comprises the following raw materials in parts by weight: 15 parts of black medlar, 15 parts of mulberry, 10 parts of cowberry fruit, 15 parts of cassia seed, 10 parts of kudzu root, 10 parts of chrysanthemum, 10 parts of medlar, 2 parts of lutein, 0.1 part of vitamin A and 0.05 part of beta-carotene.

A preparation method of black wolfberry lutein chewable tablets for protecting eyesight comprises the following steps:

extracting black medlar, mulberry and cowberry fruit at low temperature in the whole process:

s1: weighing 15 parts of lycium ruthenicum, 15 parts of mulberry and 10 parts of cowberry, removing impurities, cleaning, drying and crushing; crushing to 30 meshes, mixing and standby;

s2: weighing 30 parts of processed lycium ruthenicum mill, mulberry and cowberry mixed raw materials, and adding the raw materials according to the weight ratio of M: adding water in the ratio of M to water of 1:10, circularly extracting at low temperature, filtering and separating residues;

s3: adding the rest mixed raw material powder into the extract obtained in S2, extracting at low temperature, controlling the extraction temperature at 50-60 deg.C, extracting for 2 hr, filtering and separating residue;

s4: performing multi-stage reverse osmosis concentration and low-temperature recrystallization on the extracting solution obtained in the step S3 to obtain lycium ruthenicum murr, mulberry and cowberry anthocyanin extracts;

extracting cassia seed, kudzuvine root and chrysanthemum:

s5: weighing 15 parts of cassia seed, 10 parts of kudzu root and 10 parts of chrysanthemum, removing impurities, cleaning, drying and crushing; crushing to 30 meshes, mixing and standby;

s6: extracting the processed mixed powder of the cassia seed, the kudzuvine root and the chrysanthemum with water twice, adding water with the amount 10 times of the material amount for the first time, and extracting for 1.5h by hot reflux; taking primary filtrate; adding 8 times of water into the residue for the second time, extracting under reflux for 1.5 hr, and mixing the filtrates to obtain mixed extractive solution;

s7: taking the extract obtained in S6, concentrating the extract under reduced pressure until the relative density is 1.0-1.1, and mixing the following raw materials in percentage by weight: adding maltodextrin into the mixture with the ratio of 1:0.2, and spray drying to obtain extracts of semen Cassiae, radix Puerariae and flos Chrysanthemi;

and (3) wolfberry polysaccharide extraction:

s8: weighing 10 parts of medlar, drying, and crushing to small fragments of 0.2-0.3cm for later use;

s9: adding 10 times of water, heating and boiling for extraction for 2 times, each time for 2 hours, combining the two extracting solutions, concentrating and evaporating water until the specific gravity d is 1.20 of extract, standing and cooling, wherein the ratio of the extract to the extract is M: m ethanol ═ 1: 8, adding 80% ethanol, stirring, standing overnight, and centrifuging to obtain precipitate; adding 2 times of 80% ethanol into the precipitate again, washing, and drying under reduced pressure to obtain fructus Lycii crude polysaccharide;

s10: weighing 2 parts of lutein, 0.1 part of vitamin A and 0.5 part of beta-carotene according to a formula proportion, adding the extract of the black wolfberry fruit, the mulberry fruit, the cowberry fruit, the cassia seed, the radix puerariae and the chrysanthemum and the lycium barbarum polysaccharide extract, uniformly mixing, and tabletting to obtain the tablet.

As a further scheme of the invention, in S2, the extraction temperature is controlled to be 50-60 ℃, and the extraction time is 2 h.

As a further scheme of the invention, in S4, the anthocyanin content reaches 11%, the reverse osmosis concentration pore diameter is 0.1-0.5nm, and the recrystallization temperature is 15-25 ℃.

As a further scheme of the invention, in S7, the spray drying conditions are that the inlet air temperature is 165-.

The cassia seed is a traditional Chinese medicine food material, and contains active ingredients such as chrysophanol, emodin, cassia tora essence, aurantio-obtusin and vitamin A according to the record of a Chinese medicine dictionary. The cassia seed recorded in Chinese pharmacopoeia has the efficacies of clearing liver and improving vision, red eyes and unsmooth eyes and poor vision.

Kudzu vine root is a core medicinal material for improving eyesight and protecting liver, contains active ingredients such as puerarin, puerarin xyloside, soybean flavone, beta-sitosterol, arachidic acid and the like, and the modern research shows that kudzu vine root flavonoid substances can increase the supply of blood to oxygen and relieve vision and physical fatigue.

The extract of lycium ruthenicum and mulberry contains anthocyanin as main component, which has the functions of resisting oxidation and scavenging free radicals, because the anthocyanin belongs to flavone substances. The main physiological activity of the flavone substance is to remove free radicals or oxidation resistance, and simultaneously, the flavone substance has the functions of protecting capillaries, increasing the regeneration of visible red blood cells and protecting eyes and eyesight. Research shows that anthocyanin is found by people at present, and the most effective antioxidant is also a stronger free radical scavenger, so that the anthocyanin has great benefits on relieving fatigue and resisting aging; meanwhile, the anthocyanin is not only a nutrient enhancer in food, but also a natural additive of food, and has irreplaceable effect as a preservative of food.

The cowberry fruit is rich in anthocyanin, and has effects of protecting capillary vessel, increasing regeneration of erythrocyte, and protecting eye and vision.

Xanthophyll, the main component of macula lutea in eyes, can prevent the aging of macula lutea, has filtering effect on ultraviolet, and can prevent and treat the damage of ultraviolet to eyes and eyesight.

Vitamin C is structurally similar to glucose, and is a polyhydroxy compound in which two adjacent enol-type hydroxyl groups at the 2 nd and 3 rd positions in the molecule are easily dissociated to release H +, and thus has an acid property, which is also called ascorbic acid. Vitamin C is necessary for antibody and collagen formation, tissue repair (including certain oxidation-reduction effects), metabolism of phenylalanine, tyrosine and folic acid, utilization of iron and carbohydrate, synthesis of fat and protein, maintenance of immune function, hydroxylation of 5-hydroxytryptamine, blood vessel integrity maintenance, non-heme iron absorption promotion and the like, and simultaneously the vitamin C also has the effects of oxidation resistance, free radical resistance and tyrosinase inhibition, so that the effects of resisting aging and nourishing optic nerve cells are achieved.

Vitamin A has multiple physiological functions of promoting growth and reproduction, maintaining normal secretion of bones, epithelial tissues, eyesight and mucous epithelium, and the like, and has a protective effect on optic nerves.

Beta-carotene is an antioxidant. After the beta-carotene enters the body, 50% of the beta-carotene is changed into vitamin A under the action of enzyme in the liver and small intestine mucosa, has the functions of tonifying liver and improving eyesight, and can be used for treating nyctalopia; benefiting diaphragm and widening intestine. The beta-carotene can be converted into vitamin A after entering human body, and the conversion has adjustability.

The invention has the beneficial effects that:

the cassia seed is a traditional Chinese medicine food material, and contains active ingredients such as chrysophanol, emodin, cassia tora essence, aurantio-obtusin and vitamin A according to the record of a Chinese medicine dictionary. Has the effects of clearing liver and improving vision, and relieving pain and darkness; the xanthophyll is the main component of macula lutea in eyes, and can prevent aging of macula lutea, filter ultraviolet, and prevent and treat ultraviolet injury to eyes and eyesight. Radix Puerariae and flos Chrysanthemi are combined for clearing liver-fire, improving eyesight, relieving asthenopia and reducing blood lipid. The black wolfberry, the mulberry and the cowberry fruit contain rich anthocyanin, protect capillary vessels, increase the regeneration of visual red cells, effectively protect eyes and eyesight and prevent and treat the damage of ultraviolet rays to the eyes. The lycium barbarum polysaccharide has stronger biological activity, is easy to absorb and utilize, and has better effects of reducing high blood pressure, high blood sugar, high blood lipid, high blood pressure, high blood sugar, high blood fat, high blood. The vitamin A can effectively improve the generation of the rhodopsin in the eyes and reduce the dryness degree of the eyes and the night blindness phenomenon. The raw materials for preparing the medicine composition for protecting eyesight and relieving asthenopia are fewer, the synthesis process is simple, the production cost is reduced, besides the simple function of relieving asthenopia, the medicine composition also has various medicinal effects of relieving spasm, resisting inflammation, reducing blood pressure, preventing cardiovascular and cerebrovascular diseases and the like, and the medicine functions are enriched.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Example 1:

the black wolfberry lutein chewable tablet for protecting eyesight comprises the following raw materials in parts by weight: 15 parts of black medlar, 15 parts of mulberry, 10 parts of cowberry fruit, 15 parts of cassia seed, 10 parts of kudzu root, 10 parts of chrysanthemum, 10 parts of medlar, 2 parts of lutein, 0.1 part of vitamin A and 0.05 part of beta-carotene;

s2: weighing 30 parts of processed lycium ruthenicum mill, mulberry and cowberry mixed raw materials, and adding the raw materials according to the weight ratio of M: adding water in a ratio of M water to 1:10, circularly extracting at low temperature, controlling the extraction temperature to be 50-60 ℃, extracting for 2h, filtering and separating residues;

s4: performing multi-stage reverse osmosis concentration and low-temperature recrystallization on the extracting solution obtained in the step S3 to obtain lycium ruthenicum murr, mulberry and cowberry anthocyanin extracts; wherein the anthocyanin content reaches 11%, the reverse osmosis concentration aperture is 0.1-0.5nm, and the recrystallization temperature is 15-25 ℃;

extracting cassia seed, kudzuvine root and chrysanthemum:

s6: extracting the processed mixed powder of the cassia seed, the kudzuvine root and the chrysanthemum with water twice, adding water with the amount 10 times of the material amount for the first time, and extracting for 1.5h by hot reflux; taking primary filtrate; adding 8 times of water into the residue for the second time, extracting under reflux for 1.5 hr, and mixing the filtrates to obtain mixed extractive solution.

S7: taking the extract obtained in S6, concentrating the extract under reduced pressure until the relative density is 1.0-1.1, and mixing the following raw materials in percentage by weight: adding maltodextrin into the mixture with the ratio of 1:0.2, and spray drying to obtain extracts of semen Cassiae, radix Puerariae and flos Chrysanthemi; wherein the spray drying conditions comprise an inlet air temperature of 165-175 ℃, an outlet air temperature of 80-90 ℃ and a pressure in the tower of-35 to-40 Pa.

And (3) wolfberry polysaccharide extraction:

Example 2:

the black wolfberry lutein chewable tablet for protecting eyesight comprises the following raw materials in parts by weight: 17 parts of black medlar, 17 parts of mulberry, 12 parts of cowberry fruit, 17 parts of cassia seed, 12 parts of kudzu root, 12 parts of chrysanthemum, 12 parts of medlar, 2 parts of lutein, 0.1 part of vitamin A and 0.5 part of beta-carotene;

s1: weighing 17 parts of lycium ruthenicum, 17 parts of mulberry and 12 parts of cowberry, removing impurities, cleaning, drying and crushing; crushing to 30 meshes, mixing and standby;

s3: mixing the rest raw material powder of Lycium ruthenicum Murr, Mori fructus and cowberry fruit, adding the extractive solution obtained in S2, extracting at low temperature controlled at 50-60 deg.C for 2 hr, filtering and separating residue;

extracting cassia seed, kudzuvine root and chrysanthemum:

s5: weighing 17 parts of cassia seed, 12 parts of kudzuvine root and 12 parts of chrysanthemum, removing impurities, cleaning, drying and crushing; crushing to 30 meshes, mixing and standby;

And (3) wolfberry polysaccharide extraction:

s8: weighing 12 parts of medlar, drying, and crushing to small fragments of 0.2-0.3cm for later use;

Example 3:

the black wolfberry lutein chewable tablet for protecting eyesight comprises the following raw materials in parts by weight: 20 parts of black medlar, 20 parts of mulberry, 15 parts of cowberry fruit, 20 parts of cassia seed, 15 parts of kudzu root, 15 parts of chrysanthemum, 15 parts of medlar, 2 parts of lutein, 0.1 part of vitamin A and 0.05 part of beta-carotene;

s1: weighing 20 parts of lycium ruthenicum, 20 parts of mulberry and 15 parts of cowberry, removing impurities, cleaning, drying and crushing; crushing to 30 meshes, mixing and standby;

extracting cassia seed, kudzuvine root and chrysanthemum:

s5: weighing 20 parts of cassia seed, 15 parts of kudzu root and 15 parts of chrysanthemum, removing impurities, cleaning, drying and crushing; crushing to 30 meshes, mixing and standby;

And (3) wolfberry polysaccharide extraction:

s8: weighing 15 parts of medlar, drying, and crushing to small fragments of 0.2-0.3cm for later use;

Comparative example:

a Chinese medicinal composition taken from a comparison document CN 107519338A.

Clinical experiments are as follows:

four patients, named Xuezao, male, age 41, with photophobia, soreness of the eyes, and lacrimation, took the medication of example 1 for 1 week.

Patient two, old and male, 35 years old, suffered from symptoms of eye spasm, eye soreness, and lacrimation, and took the medicine obtained in example 2 for 1 week.

Patient three, wu-chi, female, age 46, with symptoms of eye spasm, photophobia, lacrimation, took the medication obtained in example 3 for 1 week.

Patient four, wangzhi, female, age 49, with symptoms of photophobia, ocular soreness, lacrimation, used the drug from the comparative example for 1 week.

The results are shown in Table 1:

TABLE 1

Patient's health	Photophobia	Soreness of the eyes	Eye fatigue	Spasm of the eye
					Patient one	Disappearance of symptoms	Disappearance of symptoms	Disappearance of symptoms	Is free of
Patient 2	Is free of	Disappearance of symptoms	Disappearance of symptoms	Obvious improvement of symptoms
					Patient three	Disappearance of symptoms	Is free of	Disappearance of symptoms	Obvious improvement of symptoms
Patient four	Adapted only to weak light	Has no obvious improvement	Is reduced to some extent	Is free of

According to the above experimental results, the pharmaceutical compositions obtained in examples 1 to 3 are significantly better than the traditional Chinese medicine composition provided in the comparative example in terms of treatment of photophobia, soreness and pain of eyes, eye fatigue, blurred vision, and eye spasm.

The above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.

Claims

1. The black wolfberry lutein chewable tablet for protecting eyesight is characterized in that the pharmaceutical composition comprises the following raw materials in parts by weight: 15-20 parts of black wolfberry, 15-20 parts of mulberry, 10-15 parts of cowberry fruit, 15-20 parts of cassia seed, 10-15 parts of kudzu root, 10-15 parts of chrysanthemum, 10-15 parts of wolfberry, 2 parts of lutein, 0.1 part of vitamin C, 0.05 part of vitamin A and 0.05 part of beta-carotene.

2. A preparation method of black wolfberry lutein chewable tablets for protecting eyesight is characterized by comprising the following steps:

s1: weighing 15-20 parts of lycium ruthenicum, 15-20 parts of mulberry and 10-15 parts of cowberry, removing impurities, cleaning, drying and crushing; crushing to 30 meshes, mixing and standby;

extracting cassia seed, kudzuvine root and chrysanthemum:

s5: weighing 15-20 parts of cassia seed, 10-15 parts of kudzu root and 10-15 parts of chrysanthemum, removing impurities, cleaning, drying and crushing; crushing to 30 meshes, mixing and standby;

and (3) wolfberry polysaccharide extraction:

s8: weighing 10-15 parts of medlar, drying, and crushing to small fragments of 0.2-0.3cm for later use;

s10: weighing 2 parts of lutein, 0.1 part of vitamin C, 0.05 part of vitamin A and 0.05 part of beta-carotene according to the formula proportion, adding the extract of the black wolfberry fruit, the mulberry fruit and the cowberry fruit, the extract of the cassia seed, the kudzuvine root and the chrysanthemum and the extract of the lycium barbarum polysaccharide, uniformly mixing, and tabletting to obtain the product.

3. The method for preparing eyesight-protecting chewable tablet of lycium ruthenicum and lutein according to claim 2, wherein the extraction temperature is controlled to 50-60 ℃ and the extraction time is 2h in S2.

4. The method for preparing a chewable tablet of lycium ruthenicum and lutein for eyesight protection according to claim 2, wherein in S4, the anthocyanin content is 11%, the reverse osmosis concentration pore size is 0.1-0.5nm, and the recrystallization temperature is 15-25 ℃.

5. The method for preparing black wolfberry lutein chewable tablets for eyesight protection as claimed in claim 2, wherein in S7, the spray drying conditions are air inlet temperature 165-175 ℃, air outlet temperature 80-90 ℃, and pressure in the tower is-35 to-40 Pa.