CN105687483A - Granular preparation with function of improving eyesight - Google Patents
Granular preparation with function of improving eyesight Download PDFInfo
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- CN105687483A CN105687483A CN201610131416.6A CN201610131416A CN105687483A CN 105687483 A CN105687483 A CN 105687483A CN 201610131416 A CN201610131416 A CN 201610131416A CN 105687483 A CN105687483 A CN 105687483A
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- granular preparation
- vitamin
- mixed powder
- extract
- semen cassiae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/45—Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
Abstract
The invention belongs to the field of nutrition and health care and relates to a granular preparation with a function of improving eyesight. The granular preparation is prepared from a Vaccinium myrtillus extract, a fructus lycii extract, lutein ester, resveratrol, cassia seeds, burdock roots, vitamin A, vitamin C, isomalt, starch and maltodextrin. The granular preparation is prepared according to the health maintenance principle of traditional Chinese medicines in combination with modern nutriology, the formula is reasonable, and the granular preparation is simple to take, can realize the efficacy of improving the eyesight after being brewed with water and can be prepared in a form of filled capsules or pressed tablets which are more conveniently carried and taken.
Description
Technical field
The present invention relates to nourishing healthy field, particularly to a kind of granular preparation having and improving vision effect。
Background technology
Along with the high development of science and technology and industrial civilization, computer, flat board, smart mobile phone have covered our life comprehensively。Eyes; as the first carrier accepting information, being also stimulated by the screen light of various smart machines all the time, the activity letting alone often stay up late overtime work or high light stimulation (is fished; drive), the malaise symptoms such as dry and astringent, the sour swollen even twinge of eyes often occur。If being not added with conditioning, in the past for a long time, irreversible ophthalmic injuries will be caused。
Meanwhile, along with the continuous growth at age, every function of health begins to decline。Research shows, eyes are one of organs of falling into a decline at first。Clinical medicine is thought: along with being continuously increased of age, due to reason or the health other diseases (hyperlipidemia, hypertension etc.) of eyes self, can be inevitably generated the ophthalmic diseasess such as hypermetropia, glass crystal muddiness, fundus flavimaculatus, cataract。Medical science both domestic and external and threpsology expert represent: improved vision and above-mentioned ill symptoms by oral formulations。
For now, market occurs improve vision or the product of alleviating asthenopia is not a lot, mainly based on eye drop。It addition, also someone can select to brew the Chinese medicinal material such as Flos Chrysanthemi, Semen Cassiae。But, all there is certain shortcoming in these products or method: the effect that the products such as (1) eye drop play is mainly physics and alleviates dry and astringent and refrigerant stimulation, belongs to and cures the symptoms, not the disease, and uses more complicated；(2) many people do not understand theory of Chinese medical science, and mediation of will not arranging in pairs or groups selects, and is absorbed in the border of blindness, and mismatch occurs in the dietetic therapy material being used for nursing one's health, or is not inconsistent with body constitution, in the past for a long time, only can run counter to desire。
Summary of the invention
In view of this, it is an object of the invention to provide a kind of granular preparation having and improving vision effect, change granular preparation and adopt the Traditional Chinese Medicine way to keep in good health, in conjunction with modern nutriology, formula is reasonable, simply eaten, brews with water to drink and can reach to improve vision effect, capsule can also be recorded and be pressed into tablet, more convenient to carry with take。
For achieving the above object, the present invention provides following technical scheme:
A kind of have the granular preparation improving vision effect, is made up of European Pericarpium Citri tangerinae extract, wolfberry fruit extract, lutein ester, resveratrol, Semen Cassiae, Radix Arctii, vitamin A, vitamin C, hydroxyl isomaltulose, starch, maltodextrin。
Wherein,
European Pericarpium Citri tangerinae extract: rich in anthocyanidin, it is possible to promote the rhodopsin regeneration in retina cell, pre-myopia prevention, promote vision。
Wolfberry fruit extract: nourishing the liver and kidney, replenishing vital essence to improve eyesight。
Lutein ester: protection macula lutea, promotes that macula lutea is grown, prevents degeneration of macula and retinitis pigmentosa, reduce the generation of glass-film wart。
Resveratrol: there is extremely strong oxidation resistance, it is possible to prevent and delay eye old and feeble。
Semen Cassiae: clearing away heat to improve acuity of vision。
Radix Arctii: dissipating wind heat, sterilization is swollen。
Vitamin A: have another name called retinol, it is possible to maintain normal vision function。
Vitamin C: have stronger antioxidation, improves the nutriture of eyeglass。
Isomaltulose, starch, maltodextrin: as the adjuvant of granular preparation, it is ensured that preparation process molding。
Technical scheme utilizes European Pericarpium Citri tangerinae extract, lutein ester, vitamin A to supplement the nutrients such as rhodopsin, retinol and flavin, improves the nutriture of eyes；Utilize tcm health preserving effect of wolfberry fruit extract, Semen Cassiae and Radix Arctii, nourishing liver and kidney, clearing away heat to improve acuity of vision；Utilize resveratrol, ascorbic strong antioxidant action, remove the free radical of eye, delay eye old and feeble。Eye is mutually acted synergistically on, thus reaching to improve the effect of vision by three above aspect effect。
Further, in the present invention:
(1) European Pericarpium Citri tangerinae extract is by European Pericarpium Citri tangerinae concentration after homogenate, enzymolysis, macroporous resin exchange, dry gained。
(2) wolfberry fruit extract is by the ratio of Fructus Lycii and 60% ethanol 1:8 by weight, concentration after 3 hours reflux extract, dry gained。
The preferred technical solution of the present invention is:
A kind of have the granular preparation improving vision effect and include following component by weight: European Pericarpium Citri tangerinae extract 20-40 part, wolfberry fruit extract 50-100 part, lutein ester 10-20 part, resveratrol 30-50 part, Semen Cassiae 50-100 part, Radix Arctii 30-50 part, vitamin A 5-10 part, vitamin C 30-50 part, hydroxyl isomaltulose 500-700 part, starch 100-200 part, maltodextrin 50-100 part。
The present invention also provides for the preparation scheme of above-mentioned granular preparation:
Step 1, Radix Arctii, Semen Cassiae powder are broken into the powder of 80 order granularities。
Step 2, weigh European Pericarpium Citri tangerinae extract, wolfberry fruit extract, lutein ester, resveratrol, Semen Cassiae, Radix Arctii, vitamin A, vitamin C, mix homogeneously, obtain mixed powder 1；
Step 3, weigh hydroxyl isomaltulose, starch, maltodextrin, add mixed powder 1, mix homogeneously, obtain mixed powder 2；
Step 4, using the alcoholic solution of 60%-80% concentration as wetting agent, by mixed powder soft material；
Step 5, by the soft material granulation prepared in step 4, dry, granulate, to obtain final product。
The granular preparation of the present invention can brew and drink by direct water, it is possible to capsule is made in fill, and the magnesium stearate that more can add 1-3 weight portion further is pressed into tablet。
The present invention has the following advantages and beneficial effect:
(1) this granular preparation, carries out scientific compatibility according to theory of Chinese medical science in conjunction with modern nutriology, to reach to improve effect of vision, compared to prior art and product, and more comprehensive and safety。
(2) this granular preparation plays effect by scientific compatibility, synergistic mode, by improving eye crystalline lens nutrition, multiple approach such as nourishing the liver and kidney, improving eyesight and antioxidation delay eye old and feeble carry out lasting effects, and ratio prior art and product, more deeply with effective。
(3) this granular preparation instant, it is only necessary to brew with water and namely drinkable concurrently wave effect。Can recording capsule and tabletting further, convenient going out is carried and is taken。
Specific embodiment
The invention discloses a kind of granular preparation having and improving vision effect, those skilled in the art can use for reference present disclosure, is suitably modified parameter and realizes。Special needs to be pointed out is, all similar replacements and change apparent to those skilled in the art, they are considered as including in the present invention。Detection method of the present invention is described already by preferred embodiment, and method described herein and application substantially can be modified or suitably change and combination by related personnel in without departing from present invention, spirit and scope, realize and apply the present invention。
For setting forth the present invention better, below will be illustrated by specific embodiment。
Embodiment 1:
1, by Radix Arctii, Semen Cassiae, it is ground into the powder of 80 order granularities。
2, weigh European Pericarpium Citri tangerinae extract 200g, wolfberry fruit extract 500g, lutein ester 100g, resveratrol 300g, Semen Cassiae 500g, Radix Arctii 300g, vitamin A 50g, vitamin C 300g, mix homogeneously, obtain mixed powder 1；
3, weigh hydroxyl isomaltulose 5000g, starch 1000g, maltodextrin 500g, add mixed powder 1, mix homogeneously, obtain mixed powder 2；
4, using the alcoholic solution of 60% concentration as wetting agent, by mixed powder soft material；
5, by the soft material granulation prepared in step 4, dry, granulate, to obtain final product。
Embodiment 2:
1, by Radix Arctii, Semen Cassiae, it is ground into the powder of 80 order granularities。
2, weigh European Pericarpium Citri tangerinae extract 400g, wolfberry fruit extract 1000g, lutein ester 200g, resveratrol 500g, Semen Cassiae 1000g, Radix Arctii 500g, retinol1 00g, vitamin C 500g, mix homogeneously, obtain mixed powder 1；
3, weigh hydroxyl isomaltulose 7000g, starch 2000g, maltodextrin 1000g, add mixed powder 1, mix homogeneously, obtain mixed powder 2；
4, using the alcoholic solution of 80% concentration as wetting agent, by mixed powder soft material；
5, by the soft material granulation prepared in step 4, dry, granulate, to obtain final product。
Embodiment 3:
1, by Radix Arctii, Semen Cassiae, it is ground into the powder of 80 order granularities。
2, weigh European Pericarpium Citri tangerinae extract 300g, wolfberry fruit extract 700g, lutein ester 150g, resveratrol 400g, Semen Cassiae 700g, Radix Arctii 400g, vitamin A 80g, vitamin C 400g, mix homogeneously, obtain mixed powder 1；
3, weigh hydroxyl isomaltulose 6000g, starch 1500g, maltodextrin 800g, add mixed powder 1, mix homogeneously, obtain mixed powder 2；
4, using the alcoholic solution of 70% concentration as wetting agent, by mixed powder soft material；
5, by the soft material granulation prepared in step 4, dry, granulate。
6, the granule that will prepare in step 5, adds 20g magnesium stearate, tabletting, obtains tablet of the present invention。
Embodiment 4:
1, by Radix Arctii, Semen Cassiae, it is ground into the powder of 80 order granularities。
2, weigh European Pericarpium Citri tangerinae extract 350g, wolfberry fruit extract 750g, lutein ester 160g, resveratrol 350g, Semen Cassiae 800g, Radix Arctii 450g, vitamin A 70g, vitamin C 350g, mix homogeneously, obtain mixed powder 1；
3, weigh hydroxyl isomaltulose 6500g, starch 1400g, maltodextrin 700g, add mixed powder 1, mix homogeneously, obtain mixed powder 2；
4, using the alcoholic solution of 65% concentration as wetting agent, by mixed powder soft material；
5, by the soft material granulation prepared in step 4, dry, granulate。
6, the granule that will prepare in step 5, pours into hard capsule, obtains capsule product of the present invention。
Embodiment 5:
The preparation that embodiment 1-3 is prepared gained has the crowd of asthenopia symptom respectively to 30 clinics, and everyone takes 30 days continuously, adds up effect after 30 days。Following table is human test results:
By the above results it can be seen that the standard according to " health food inspection with assessment technique specification (2003 editions) " revised edition alleviating asthenopia judges, it was demonstrated that embodiment 1-3 gained preparation has and improves visual function。
The above is only only certain exemplary embodiments of this invention; it should be pointed out that, for those skilled in the art, under the premise without departing from the principles of the invention; can also making some improvements and modifications, these improvements and modifications also should be regarded as protection scope of the present invention。
Claims (4)
1. one kind has the granular preparation improving vision effect, it is characterized in that, described granular preparation is made up of European Pericarpium Citri tangerinae extract, wolfberry fruit extract, lutein ester, resveratrol, Semen Cassiae, Radix Arctii, vitamin A, vitamin C, hydroxyl isomaltulose, starch, maltodextrin。
2. the granular preparation according to claim 1, it is characterized in that, described granular preparation by weight consist of European Pericarpium Citri tangerinae extract 20-40 part, wolfberry fruit extract 50-100 part, lutein ester 10-20 part, resveratrol 30-50 part, Semen Cassiae 50-100 part, Radix Arctii 30-50 part, vitamin A 5-10 part, vitamin C 30-50 part, hydroxyl isomaltulose 500-700 part, starch 100-200 part, maltodextrin 50-100 part。
3. the granular preparation according to claim 1, it is characterised in that the preparation method of described granular preparation comprises the following steps:
Step 1, Radix Arctii, Semen Cassiae powder are broken into the powder of 80 order granularities；
Step 2, weigh European Pericarpium Citri tangerinae extract, wolfberry fruit extract, lutein ester, resveratrol, Semen Cassiae, Radix Arctii, vitamin A, vitamin C, mix homogeneously, obtain mixed powder 1；
Step 3, weigh hydroxyl isomaltulose, starch, maltodextrin, add mixed powder 1, mix homogeneously, obtain mixed powder 2；
Step 4, using the alcoholic solution of 60%-80% concentration as wetting agent, by mixed powder soft material；
Step 5, by the soft material granulation prepared in step 4, dry, granulate, to obtain final product。
4. the granular preparation according to any one of claim 1-3, it is characterised in that described granular preparation also fill can make capsule, the magnesium stearate that more can add 1-3 weight portion further is pressed into tablet。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610131416.6A CN105687483A (en) | 2016-03-09 | 2016-03-09 | Granular preparation with function of improving eyesight |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610131416.6A CN105687483A (en) | 2016-03-09 | 2016-03-09 | Granular preparation with function of improving eyesight |
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| CN105687483A true CN105687483A (en) | 2016-06-22 |
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| CN201610131416.6A Pending CN105687483A (en) | 2016-03-09 | 2016-03-09 | Granular preparation with function of improving eyesight |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107213271A (en) * | 2017-05-31 | 2017-09-29 | 江苏朸健生命科技发展有限公司 | One kind alleviates asthenopia tablet and preparation method thereof |
| CN108902624A (en) * | 2018-07-20 | 2018-11-30 | 天津市活力源饮料有限公司 | Improving eyesight solid beverage and preparation method thereof |
| CN110959735A (en) * | 2019-12-17 | 2020-04-07 | 天津市尖峰天然产物研究开发有限公司 | Candy added with vaccinium myrtillus extract and preparation method thereof |
| CN111214640A (en) * | 2020-04-01 | 2020-06-02 | 梭医生物科技(上海)股份有限公司 | Leaf yellow Chinese wolfberry tablet capable of rapidly improving eyesight and preparation method thereof |
| CN111821355A (en) * | 2020-08-06 | 2020-10-27 | 河北康平健康产业有限责任公司 | Eyesight-protecting lycium ruthenicum and lutein chewable tablet and preparation method thereof |
| CN113558247A (en) * | 2021-08-03 | 2021-10-29 | 汤臣倍健股份有限公司 | A method for preparing tablet containing high content of milk mineral salt |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103070877A (en) * | 2012-12-26 | 2013-05-01 | 陈阳 | Vision care drug |
| CN103202472A (en) * | 2013-04-25 | 2013-07-17 | 福建永生活力生物工程有限公司 | Health food for relieving visual fatigues and preparation method of health food |
| CN104968335A (en) * | 2013-01-07 | 2015-10-07 | 三亚制药(株) | Novel fast-dissolving granule formulation having improved solubility |
-
2016
- 2016-03-09 CN CN201610131416.6A patent/CN105687483A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103070877A (en) * | 2012-12-26 | 2013-05-01 | 陈阳 | Vision care drug |
| CN104968335A (en) * | 2013-01-07 | 2015-10-07 | 三亚制药(株) | Novel fast-dissolving granule formulation having improved solubility |
| CN103202472A (en) * | 2013-04-25 | 2013-07-17 | 福建永生活力生物工程有限公司 | Health food for relieving visual fatigues and preparation method of health food |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107213271A (en) * | 2017-05-31 | 2017-09-29 | 江苏朸健生命科技发展有限公司 | One kind alleviates asthenopia tablet and preparation method thereof |
| CN108902624A (en) * | 2018-07-20 | 2018-11-30 | 天津市活力源饮料有限公司 | Improving eyesight solid beverage and preparation method thereof |
| CN110959735A (en) * | 2019-12-17 | 2020-04-07 | 天津市尖峰天然产物研究开发有限公司 | Candy added with vaccinium myrtillus extract and preparation method thereof |
| CN111214640A (en) * | 2020-04-01 | 2020-06-02 | 梭医生物科技(上海)股份有限公司 | Leaf yellow Chinese wolfberry tablet capable of rapidly improving eyesight and preparation method thereof |
| CN111821355A (en) * | 2020-08-06 | 2020-10-27 | 河北康平健康产业有限责任公司 | Eyesight-protecting lycium ruthenicum and lutein chewable tablet and preparation method thereof |
| CN113558247A (en) * | 2021-08-03 | 2021-10-29 | 汤臣倍健股份有限公司 | A method for preparing tablet containing high content of milk mineral salt |
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Application publication date: 20160622 |
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