CN113558247A - A method for preparing tablet containing high content of milk mineral salt - Google Patents

A method for preparing tablet containing high content of milk mineral salt Download PDF

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CN113558247A
CN113558247A CN202110884156.0A CN202110884156A CN113558247A CN 113558247 A CN113558247 A CN 113558247A CN 202110884156 A CN202110884156 A CN 202110884156A CN 113558247 A CN113558247 A CN 113558247A
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mineral salt
milk mineral
tablet
milk
high content
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CN113558247B (en
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黄仪友
王英
黄远英
麦绮莹
陈强
殷光玲
张旭光
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BY Health Co Ltd
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BY Health Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/015—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/03—Organic compounds
    • A23L29/035—Organic compounds containing oxygen as heteroatom
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/03—Organic compounds
    • A23L29/035—Organic compounds containing oxygen as heteroatom
    • A23L29/04—Fatty acids or derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/19—Dairy proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/20—Agglomerating; Granulating; Tabletting
    • A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Botany (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The invention discloses a preparation method of a tablet containing high-content milk mineral salt components, which comprises the following steps: mixing semen glycines extract, milk mineral salt, dextrin, isomaltitol, colostrum alkaline protein powder, and collagen powder uniformly, adding adhesive, granulating, drying, and sieving to obtain milk mineral salt-containing granule; mixing the milk-containing mineral salt granules, filler, disintegrant and lubricant, and tabletting to obtain tablet containing high content of milk mineral salt. The ratio of the milk mineral salt materials in the tablets prepared by the method is increased to 40-65%, and the content of calcium in each tablet is greatly increased. When the soft material is prepared, the granulation property is good, the tablet weight fluctuation is small, the hardness is stable, the phenomena of tablet breaking, edge breaking and the like do not occur in the coating process, the formability of the tablet is improved, the hardness, the friability and the disintegration time limit are improved, and the feasibility of the production process is improved.

Description

A method for preparing tablet containing high content of milk mineral salt
Technical Field
The invention relates to the field of health-care food or food, in particular to a preparation method of a tablet containing high-content milk mineral salt components.
Background
Tablets are one of the most widely used dosage forms. The preparation method of the tablet comprises wet granulation tabletting, dry granulation tabletting, direct powder tabletting, direct crystallization tabletting and the like. Among them, wet granulation and tableting are most commonly used. The preparation method of the tablet not only influences the physicochemical properties (such as appearance, dissolution rate, stability and the like) of the product, but also possibly influences the effect of the product after taking. Therefore, it is very important to study the preparation method of the tablet.
The health food contains more calcium-supplementing products, milk mineral salt is used as a calcium source, the content of milk mineral salt raw materials is generally 10-35% when the health food is prepared into tablets, and excipients used for granulation generally comprise mannitol, sorbitol, crystalline fructose, white granulated sugar, glucose, carboxymethyl chitosan, silicon dioxide, magnesium stearate and the like. However, when the content of the milk mineral salt is 40% or more, the granulation property is poor when the milk mineral salt is made into a soft mass by making into tablets. During tabletting, the tablet weight fluctuation is large, the hardness is unstable, the tablet is easy to break, the edge is broken and the like in the coating process, and the product is unstable at high and low time limit during disintegration.
Disclosure of Invention
In view of the above, the present invention aims to provide a method for preparing a tablet containing a high content of milk mineral salt, which can effectively solve the technical problems existing in the tabletting of the high content of milk mineral salt.
The invention is realized by the following technical scheme:
a method for preparing a tablet containing a high content of milk mineral salt ingredients, comprising the steps of:
(1) mixing semen glycines extract, milk mineral salt, dextrin, isomaltitol, colostrum alkaline protein powder, and collagen powder uniformly, adding adhesive, granulating, drying, and sieving to obtain milk mineral salt-containing granule;
(2) mixing the milk-containing mineral salt granules, filler, disintegrant and lubricant, and tabletting to obtain tablet containing high content of milk mineral salt.
Preferably, in the tablet, by mass percentage, 2-7.5% of soybean extract, 40-65% of milk mineral salt, 2-13% of dextrin, 4-11% of isomaltitol, 2-3% of colostrum basic protein powder, 5-9% of collagen powder, 9-17% of filler, 2-3% of disintegrant, 2-3% of adhesive and 0.5-1.0% of lubricant.
Preferably, the binder is one or a mixture of several of povidone K30, povidone K90, sodium carboxymethylcellulose and hydroxypropyl methylcellulose.
Preferably, the filler is one or a mixture of more of microcrystalline cellulose, isomalt, sorbitol, xylitol, calcium hydrogen phosphate, dextrin, maltodextrin or water-soluble dietary fibers.
Preferably, the disintegrating agent is one or a mixture of several of hydroxypropyl cellulose, crospovidone, croscarmellose sodium and sodium carboxymethyl starch.
Preferably, the lubricant is one or a mixture of magnesium stearate, talcum powder and silicon dioxide.
Compared with the prior art, the invention has the following beneficial effects:
according to the method, dextrin, isomaltitol, colostrum basic protein powder and collagen powder are added into milk mineral salt and soybean extract for granulation, the milk mineral salt is diluted, viscous materials are added for adsorption, various auxiliary materials are added for mixing and tabletting, the proportion of the milk mineral salt in the prepared tablet is increased to 40% -65%, and the content of calcium in each tablet is greatly increased. When the soft material is prepared, the granulation property is good, the tablet weight fluctuation is small, the hardness is stable, the phenomena of tablet breaking, edge breaking and the like do not occur in the coating process, the formability of the tablet is improved, the hardness, the friability and the disintegration time limit are improved, and the feasibility of the production process is improved.
Detailed Description
The present invention is further illustrated by the following specific embodiments, which are not intended to limit the scope of the invention.
Comparative example 1:
the raw materials are as follows by mass percent:
7.5% of soybean extract, 43.9% of milk mineral salt, 13.6% of dextrin, 3% of colostrum basic protein powder, 5.5% of collagen powder, 20% of microcrystalline cellulose, 3% of hydroxypropyl cellulose, 3% of povidone K30 aqueous solution and 0.5% of magnesium stearate.
The preparation method comprises the following steps:
putting the soybean extract, milk mineral salt, dextrin and microcrystalline cellulose into a wet granulator, and mixing until the color is uniform; transferring the material into a boiling granulator, adding povidone K30 water solution for granulation, drying until the moisture content of the granules is 3-6% and meets the requirement, and then using a 16-20 mesh sieve for granulation; after the granules are finished, adding colostrum basic protein powder, collagen powder and hydroxypropyl cellulose magnesium stearate, and mixing until the color is uniform; tabletting was carried out using a rotary tablet press, and sampling was carried out, the results of which are shown in Table 1.
Comparative example 2:
the raw materials are as follows by mass percent:
7.5% of soybean extract, 43.9% of milk mineral salt, 8.6% of erythritol, 5% of crystalline fructose, 3% of colostrum basic protein powder, 5.5% of collagen powder, 20% of microcrystalline cellulose, 3% of hydroxypropyl cellulose, 3% of povidone K30 aqueous solution and 0.5% of magnesium stearate.
The preparation method comprises the following steps:
putting the soybean extract, milk mineral salt, erythritol and crystalline fructose into a wet granulator, and mixing until the color is uniform; transferring the material into a boiling granulator, adding povidone K30 water solution for granulation, drying until the moisture content of the granules is 3-6% and meets the requirement, and then using a 16-20 mesh sieve for granulation; after the granules are finished, colostrum basic protein powder, collagen powder, microcrystalline cellulose, hydroxypropyl cellulose and magnesium stearate are added and mixed until the color is uniform; tabletting was carried out using a rotary tablet press, and sampling was carried out, the results of which are shown in Table 1.
Comparative example 3:
the raw materials are as follows by mass percent:
7.5% of soybean extract, 43.9% of milk mineral salt, 5% of dextrin, 11% of isomalt, 3% of colostrum basic protein powder, 5.5% of collagen powder, 17.6% of microcrystalline cellulose, 3% of hydroxypropyl cellulose, 3% of povidone K30 aqueous solution and 0.5% of magnesium stearate.
The preparation method comprises the following steps:
putting the soybean extract, milk mineral salt, dextrin and isomaltitol into a wet granulator, and mixing until the color is uniform; transferring the material into a boiling granulator, adding povidone K30 water solution for granulation, drying until the moisture content of the granules is 3-6% and meets the requirement, and then using a 16-20 mesh sieve for granulation; after the granules are finished, colostrum basic protein powder, collagen powder, microcrystalline cellulose, hydroxypropyl cellulose and magnesium stearate are added and mixed until the color is uniform; tabletting was carried out using a rotary tablet press, and sampling was carried out, the results of which are shown in Table 1.
Comparative example 4:
the raw materials are as follows by mass percent:
7.5% of soybean extract, 43.9% of milk mineral salt, 5% of dextrin, 11% of isomalt, 3% of colostrum basic protein powder, 5.5% of collagen powder, 17.6% of microcrystalline cellulose, 3% of hydroxypropyl cellulose, 3% of povidone K30 aqueous solution and 0.5% of magnesium stearate.
The preparation method comprises the following steps:
putting soybean extract, milk mineral salt, dextrin, isomaltitol and 50% microcrystalline cellulose into a wet granulator, and mixing until the color is uniform; transferring the material into a boiling granulator, adding povidone K30 water solution for granulation, drying until the moisture content of the granules is 3-6% and meets the requirement, and then using a 16-20 mesh sieve for granulation; after the granules are finished, colostrum basic protein powder, collagen powder, 50 percent microcrystalline cellulose, hydroxypropyl cellulose and magnesium stearate are added and mixed until the color is uniform; tabletting was carried out using a rotary tablet press, and sampling was carried out, the results of which are shown in Table 1.
Comparative example 6:
the raw materials are as follows by mass percent:
soybean extract 7.5%, milk mineral salt 43.9%, dextrin 5%, isomalt 11%, colostrum alkaline protein powder 3%, collagen powder 5.5%, microcrystalline cellulose 17.6%, hydroxypropyl cellulose 3%, polyvidone K303%, and magnesium stearate 0.5%
The preparation method comprises the following steps:
putting soybean extract, milk mineral salt, dextrin, isomaltitol, and colostrum basic protein powder into wet granulator, and mixing to obtain uniform color; transferring the material into a boiling granulator, adding povidone K30 water solution for granulation, drying until the moisture content of the granules is 3-6% and meets the requirement, and then using a 16-20 mesh sieve for granulation; after the granules are finished, adding collagen powder, microcrystalline cellulose, hydroxypropyl cellulose and magnesium stearate, and mixing until the color is uniform; tabletting was carried out using a rotary tablet press, and sampling was carried out, the results of which are shown in Table 1.
Example 1:
the raw materials and the proportion are the same as those in comparative example 6.
The preparation method comprises the following steps:
putting soybean extract, milk mineral salt, dextrin, isomaltitol, colostrum basic protein powder and collagen powder into a wet granulator, and mixing until the color is uniform; transferring the material into a boiling granulator, adding povidone K30 water solution for granulation, drying until the moisture content of the granules is 3-6% and meets the requirement, and then using a 16-20 mesh sieve for granulation; after the granules are finished, microcrystalline cellulose, hydroxypropyl cellulose and magnesium stearate are added and mixed until the color is uniform; tabletting was carried out using a rotary tablet press, and sampling was carried out, the results of which are shown in Table 1.
Example 2:
the raw materials are as follows by mass percent:
5.0% of soybean extract, 50% of milk mineral salt, 5% of dextrin, 11% of isomaltitol, 2% of colostrum basic protein powder, 6.5% of collagen powder, 12.5% of microcrystalline cellulose, 2% of sodium carboxymethyl starch, 3% of povidone K30 aqueous solution and 0.8% of magnesium stearate.
The preparation method is the same as example 1, sampling detection is carried out, and the results are shown in Table 1.
Example 3:
the raw materials are as follows by mass percent:
5% of soybean extract, 60% of milk mineral salt, 4.3% of dextrin, 8.2% of isomaltitol, 2% of colostrum basic protein powder, 8% of collagen powder, 10.5% of microcrystalline cellulose, 2% of hydroxypropyl cellulose, 2% of povidone K30 aqueous solution and 1.0% of silicon dioxide.
The preparation method is the same as example 1, sampling detection is carried out, and the results are shown in Table 1.
Example 4:
the raw materials are as follows by mass percent:
2% of soybean extract, 65% of milk mineral salt, 2% of dextrin, 4.2% of isomaltitol, 2% of colostrum basic protein powder, 9% of collagen powder, 9.8% of microcrystalline cellulose, 3% of hydroxypropyl cellulose, 2% of povidone K90 aqueous solution and 1.0% of magnesium stearate.
The preparation method is the same as example 1, sampling detection is carried out, and the results are shown in Table 1.
Comparative example 5:
the raw materials are as follows by mass percent:
2% of soybean extract, 70% of milk mineral salt, 2% of dextrin, 4.2% of isomaltitol, 2% of colostrum basic protein powder, 6% of collagen powder, 8.8% of microcrystalline cellulose, 3% of hydroxypropyl cellulose, 1% of povidone K30 aqueous solution and 1.0% of magnesium stearate.
The preparation method is the same as example 2, sampling detection is carried out, and the results are shown in Table 1.
TABLE 1
Figure 886761DEST_PATH_IMAGE002
As can be seen from the results in Table 1, in comparative examples 1 to 4, after the soybean extract and the milk mineral salt are directly mixed with the adhesive for size stabilization, the colostrum basic protein powder, the collagen powder and other auxiliary materials are added for mixing and tabletting, the soft material has poor granularity, more fine powder and serious floating powder, and the fine powder is more and the cloth bag is easy to block during drying. The material flowability is poor during tabletting, and the material cannot be smoothly filled into the die hole of the tabletting machine and cannot be normally tabletted.
Comparative example 2 is different from comparative example 3 mainly in the addition of auxiliary materials during the granulation, comparative example 2 is added with erythritol and crystalline fructose, and comparative example 3 is added with dextrin and isomalt, and from the results, it can be shown that the granulation property of the soft material is improved by adding dextrin and isomalt, and thus, the dextrin and isomalt are selected for the granulation of the present invention.
The comparative example 4 is different from the comparative example 3 in that microcrystalline cellulose is added in two times, and from the results, it can be seen that the flowability of the comparative example 4 is deteriorated, more fine powder is obtained after granulation, the hardness of the tablet is decreased, and the fluctuation of the tablet weight is very large, which is out of the intended purpose, as compared with the comparative example 3. Therefore, the present invention adopts a mode of adding all fillers such as microcrystalline cellulose.
In comparative example 5, the ratio of milk mineral salt was too high, the granulation of soft material was poor, the difference in sheet weight was large, and the process was uncontrollable.
The difference between comparative example 6 and example 1 is whether collagen powder is added externally, in comparative example 6, colostrum basic protein powder and milk mineral salt are granulated, and the collagen powder is added externally, although the granulation performance of the soft material is improved, the best granulation is not achieved. The milk mineral salt material is light and has strong hydrophobicity, hardly generates viscosity when meeting water or being mixed with adhesive, and has poor granulation property of soft material. The collagen powder generates larger viscosity after meeting water or being mixed with an adhesive, and has better viscosity when being mixed and granulated with the milk mineral salt material, thereby making up the defects of the milk mineral salt material. The collagen powder and the corresponding materials are granulated together, so that the soft material has good granulation property, less fine powder and uniform granules. The hardness of the plain tablets is obviously improved, the fluctuation range of tablet weight is smaller, and the quality is controllable. The coating process has no phenomena of fragment and edge breaking. Therefore, the invention first granulates the collagen powder and the milk mineral salt.
In examples 1-4, dextrin, isomalt, colostrum basic protein powder, and collagen powder were added to milk mineral salt and soybean extract for granulation, and other excipients were added for mixing and tabletting, so that the soft material had good granulation property, less fine powder, and uniform granules. The hardness of the tablet can reach 21-28 kg, the hardness is obviously improved, the friability is below 0.2%, and the disintegration time is less than or equal to 35 min. The tablet weight difference is within +/-3 percent, the fluctuation range of the tablet weight is small, the phenomena of tablet breaking and edge knocking exist in the coating process, the production operation is feasible, and the quality can be controlled.

Claims (6)

1. A method for preparing a tablet containing a high content of milk mineral salt ingredients, comprising the steps of:
(1) mixing semen glycines extract, milk mineral salt, dextrin, isomaltitol, colostrum alkaline protein powder, and collagen powder uniformly, adding adhesive, granulating, drying, and sieving to obtain milk mineral salt-containing granule;
(2) mixing the milk-containing mineral salt granules, filler, disintegrant and lubricant, and tabletting to obtain tablet containing high content of milk mineral salt.
2. The method for preparing a tablet containing a high content of milk mineral salt component according to claim 1, wherein the tablet comprises, by mass, 2-7.5% of soybean extract, 40-65% of milk mineral salt, 2-13% of dextrin, 4-11% of isomalt, 2-3% of colostrum basic protein powder, 5-9% of collagen powder, 9-17% of filler, 2-3% of disintegrant, 2-3% of binder, and 0.5-1.0% of lubricant.
3. The method for preparing a tablet containing a high content of milk mineral salt ingredients according to claim 1 or 2, wherein the binder is one or a mixed solution of several of povidone K30, povidone K90, sodium carboxymethylcellulose or hydroxypropylmethyl cellulose.
4. The method for producing a tablet containing a high content of a milk mineral salt component according to claim 1 or 2, wherein the filler is one or a mixture of several of microcrystalline cellulose, isomalt, sorbitol, xylitol, dibasic calcium phosphate, dextrin, maltodextrin or water-soluble dietary fiber.
5. The method for preparing a tablet containing a high content of milk mineral salt ingredients according to claim 1 or 2, wherein the disintegrant is one or a mixture of several of hydroxypropyl cellulose, crospovidone, croscarmellose sodium or sodium carboxymethyl starch.
6. The method of claim 1 or 2, wherein the slip is one or a mixture of magnesium stearate, talc or silica.
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CN105687483A (en) * 2016-03-09 2016-06-22 宁波君瑞生物科技有限公司 Granular preparation with function of improving eyesight
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