CN108720000A - A kind of colostrum mineral salt calcium-supplementing preparation and preparation method thereof - Google Patents
A kind of colostrum mineral salt calcium-supplementing preparation and preparation method thereof Download PDFInfo
- Publication number
- CN108720000A CN108720000A CN201810440537.8A CN201810440537A CN108720000A CN 108720000 A CN108720000 A CN 108720000A CN 201810440537 A CN201810440537 A CN 201810440537A CN 108720000 A CN108720000 A CN 108720000A
- Authority
- CN
- China
- Prior art keywords
- calcium
- parts
- mineral salt
- colostrum
- vitamin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 title claims abstract description 58
- 229910052500 inorganic mineral Inorganic materials 0.000 title claims abstract description 57
- 239000011707 mineral Substances 0.000 title claims abstract description 57
- 210000003022 colostrum Anatomy 0.000 title claims abstract description 32
- 235000021277 colostrum Nutrition 0.000 title claims abstract description 32
- 238000002360 preparation method Methods 0.000 title claims abstract description 24
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 53
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims abstract description 40
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims abstract description 33
- 102000008186 Collagen Human genes 0.000 claims abstract description 27
- 108010035532 Collagen Proteins 0.000 claims abstract description 27
- 229920001436 collagen Polymers 0.000 claims abstract description 27
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 27
- 239000000463 material Substances 0.000 claims abstract description 23
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims abstract description 21
- 101710093543 Probable non-specific lipid-transfer protein Proteins 0.000 claims abstract description 21
- 229920001287 Chondroitin sulfate Polymers 0.000 claims abstract description 20
- 229910021529 ammonia Inorganic materials 0.000 claims abstract description 20
- 229940059329 chondroitin sulfate Drugs 0.000 claims abstract description 20
- 235000020243 first infant milk formula Nutrition 0.000 claims abstract description 18
- 229910000019 calcium carbonate Inorganic materials 0.000 claims abstract description 16
- 235000019359 magnesium stearate Nutrition 0.000 claims abstract description 13
- 239000011647 vitamin D3 Substances 0.000 claims abstract description 11
- 239000011728 vitamin K2 Substances 0.000 claims abstract description 7
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims abstract description 6
- 235000013336 milk Nutrition 0.000 claims description 19
- 239000008267 milk Substances 0.000 claims description 19
- 210000004080 milk Anatomy 0.000 claims description 19
- 239000005862 Whey Substances 0.000 claims description 12
- 102000007544 Whey Proteins Human genes 0.000 claims description 12
- 108010046377 Whey Proteins Proteins 0.000 claims description 12
- 239000003795 chemical substances by application Substances 0.000 claims description 12
- 239000002994 raw material Substances 0.000 claims description 12
- 238000005238 degreasing Methods 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 6
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 5
- 238000000889 atomisation Methods 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 5
- 238000004821 distillation Methods 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- VIKNJXKGJWUCNN-XGXHKTLJSA-N norethisterone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 VIKNJXKGJWUCNN-XGXHKTLJSA-N 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- 238000000108 ultra-filtration Methods 0.000 claims description 5
- 108010010803 Gelatin Proteins 0.000 claims description 3
- 239000011248 coating agent Substances 0.000 claims description 3
- 238000000576 coating method Methods 0.000 claims description 3
- 229920000159 gelatin Polymers 0.000 claims description 3
- 239000008273 gelatin Substances 0.000 claims description 3
- 235000019322 gelatine Nutrition 0.000 claims description 3
- 235000011852 gelatine desserts Nutrition 0.000 claims description 3
- 238000005096 rolling process Methods 0.000 claims description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract description 140
- 239000011575 calcium Substances 0.000 abstract description 140
- 229910052791 calcium Inorganic materials 0.000 abstract description 140
- 230000000694 effects Effects 0.000 abstract description 27
- 210000004409 osteocyte Anatomy 0.000 abstract description 19
- 239000011782 vitamin Substances 0.000 abstract description 18
- 238000010521 absorption reaction Methods 0.000 abstract description 16
- PFRQBZFETXBLTP-RCIYGOBDSA-N 2-[(2e,6e,10e,14e,18e)-3,7,11,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaen-1-yl]-3-methyl-1,4-dihydronaphthalene-1,4-dione Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)=C(C)C(=O)C2=C1 PFRQBZFETXBLTP-RCIYGOBDSA-N 0.000 abstract description 14
- WIGIZIANZCJQQY-UHFFFAOYSA-N 4-ethyl-3-methyl-N-[2-[4-[[[(4-methylcyclohexyl)amino]-oxomethyl]sulfamoyl]phenyl]ethyl]-5-oxo-2H-pyrrole-1-carboxamide Chemical compound O=C1C(CC)=C(C)CN1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCC(C)CC2)C=C1 WIGIZIANZCJQQY-UHFFFAOYSA-N 0.000 abstract description 10
- 235000016709 nutrition Nutrition 0.000 abstract description 8
- 230000008901 benefit Effects 0.000 abstract description 6
- 239000004615 ingredient Substances 0.000 abstract description 4
- 239000000203 mixture Substances 0.000 abstract description 2
- 229940057948 magnesium stearate Drugs 0.000 abstract 1
- 229960005069 calcium Drugs 0.000 description 136
- 235000010755 mineral Nutrition 0.000 description 44
- 210000004369 blood Anatomy 0.000 description 14
- 239000008280 blood Substances 0.000 description 14
- ZCCUUQDIBDJBTK-UHFFFAOYSA-N psoralen Chemical compound C1=C2OC(=O)C=CC2=CC2=C1OC=C2 ZCCUUQDIBDJBTK-UHFFFAOYSA-N 0.000 description 14
- 206010006956 Calcium deficiency Diseases 0.000 description 13
- 208000001132 Osteoporosis Diseases 0.000 description 9
- 229940088594 vitamin Drugs 0.000 description 8
- 235000013343 vitamin Nutrition 0.000 description 8
- 229930003231 vitamin Natural products 0.000 description 8
- 150000003722 vitamin derivatives Chemical class 0.000 description 8
- VXGRJERITKFWPL-UHFFFAOYSA-N 4',5'-Dihydropsoralen Natural products C1=C2OC(=O)C=CC2=CC2=C1OCC2 VXGRJERITKFWPL-UHFFFAOYSA-N 0.000 description 7
- 108010048734 sclerotin Proteins 0.000 description 6
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- 230000037182 bone density Effects 0.000 description 5
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- 108090000623 proteins and genes Proteins 0.000 description 4
- 210000002966 serum Anatomy 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 230000001360 synchronised effect Effects 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 239000003053 toxin Substances 0.000 description 4
- 231100000765 toxin Toxicity 0.000 description 4
- 208000010392 Bone Fractures Diseases 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 3
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 3
- ZQBZAOZWBKABNC-UHFFFAOYSA-N [P].[Ca] Chemical compound [P].[Ca] ZQBZAOZWBKABNC-UHFFFAOYSA-N 0.000 description 3
- 238000009534 blood test Methods 0.000 description 3
- 230000008021 deposition Effects 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
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- 238000001179 sorption measurement Methods 0.000 description 3
- 206010017076 Fracture Diseases 0.000 description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 2
- 229930003316 Vitamin D Natural products 0.000 description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
- 239000003463 adsorbent Substances 0.000 description 2
- 206010003246 arthritis Diseases 0.000 description 2
- 210000001188 articular cartilage Anatomy 0.000 description 2
- 210000002449 bone cell Anatomy 0.000 description 2
- 210000000481 breast Anatomy 0.000 description 2
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 description 2
- 239000001527 calcium lactate Substances 0.000 description 2
- 229960002401 calcium lactate Drugs 0.000 description 2
- 235000011086 calcium lactate Nutrition 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 230000036461 convulsion Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000002101 lytic effect Effects 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- 229910052749 magnesium Inorganic materials 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 201000008482 osteoarthritis Diseases 0.000 description 2
- 210000000963 osteoblast Anatomy 0.000 description 2
- 239000011574 phosphorus Substances 0.000 description 2
- 229910052698 phosphorus Inorganic materials 0.000 description 2
- 230000035479 physiological effects, processes and functions Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000035755 proliferation Effects 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- 238000004088 simulation Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 210000001258 synovial membrane Anatomy 0.000 description 2
- 239000011710 vitamin D Substances 0.000 description 2
- 235000019166 vitamin D Nutrition 0.000 description 2
- 150000003710 vitamin D derivatives Chemical class 0.000 description 2
- 229940046008 vitamin d Drugs 0.000 description 2
- 239000011701 zinc Substances 0.000 description 2
- 229910052725 zinc Inorganic materials 0.000 description 2
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 208000020084 Bone disease Diseases 0.000 description 1
- 150000004265 D-glucosamines Chemical group 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- 201000005569 Gout Diseases 0.000 description 1
- 208000012659 Joint disease Diseases 0.000 description 1
- 102000055008 Matrilin Proteins Human genes 0.000 description 1
- 108010072582 Matrilin Proteins Proteins 0.000 description 1
- ABSPRNADVQNDOU-UHFFFAOYSA-N Menaquinone 1 Natural products C1=CC=C2C(=O)C(CC=C(C)C)=C(C)C(=O)C2=C1 ABSPRNADVQNDOU-UHFFFAOYSA-N 0.000 description 1
- 229930192627 Naphthoquinone Natural products 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 241000237502 Ostreidae Species 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- PFRQBZFETXBLTP-UHFFFAOYSA-N Vitamin K2 Natural products C1=CC=C2C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C(=O)C2=C1 PFRQBZFETXBLTP-UHFFFAOYSA-N 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 238000010009 beating Methods 0.000 description 1
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 1
- 230000002457 bidirectional effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000007767 bonding agent Substances 0.000 description 1
- 230000008468 bone growth Effects 0.000 description 1
- 230000037180 bone health Effects 0.000 description 1
- 230000004097 bone metabolism Effects 0.000 description 1
- 239000004227 calcium gluconate Substances 0.000 description 1
- 229960004494 calcium gluconate Drugs 0.000 description 1
- 235000013927 calcium gluconate Nutrition 0.000 description 1
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 210000003321 cartilage cell Anatomy 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000001055 chewing effect Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- -1 cycle in blood Chemical class 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 210000001198 duodenum Anatomy 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000000630 fibrocyte Anatomy 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000007888 film coating Substances 0.000 description 1
- 238000009501 film coating Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 229960002442 glucosamine Drugs 0.000 description 1
- BHEPBYXIRTUNPN-UHFFFAOYSA-N hydridophosphorus(.) (triplet) Chemical group [PH] BHEPBYXIRTUNPN-UHFFFAOYSA-N 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 210000001630 jejunum Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- DKHGMERMDICWDU-GHDNBGIDSA-N menaquinone-4 Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)=C(C)C(=O)C2=C1 DKHGMERMDICWDU-GHDNBGIDSA-N 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 150000002791 naphthoquinones Chemical class 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 230000001582 osteoblastic effect Effects 0.000 description 1
- 230000002188 osteogenic effect Effects 0.000 description 1
- 235000020636 oyster Nutrition 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 239000011772 phylloquinone Substances 0.000 description 1
- MBWXNTAXLNYFJB-NKFFZRIASA-N phylloquinone Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CCC[C@H](C)CCC[C@H](C)CCCC(C)C)=C(C)C(=O)C2=C1 MBWXNTAXLNYFJB-NKFFZRIASA-N 0.000 description 1
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 description 1
- 235000019175 phylloquinone Nutrition 0.000 description 1
- 229960001898 phytomenadione Drugs 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- 238000012372 quality testing Methods 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 201000003068 rheumatic fever Diseases 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 235000005282 vitamin D3 Nutrition 0.000 description 1
- 235000019143 vitamin K2 Nutrition 0.000 description 1
- 229940021056 vitamin d3 Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
- A23L33/155—Vitamins A or D
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention discloses a kind of colostrum mineral salt calcium-supplementing preparations and preparation method thereof, mainly by newborn mineral salt, biological calcium carbonate, bone collagen, first milk basic protein, ammonia sugar, chondroitin sulfate, magnesium stearate, vitamin D3, vitamin K2Composition, take full advantage of the strong characteristic of newborn mineral salt own absorption ability, the absorptivity that will replenish the calcium is cooperateed with to increase substantially with vitamine D3, using first milk basic protein activate osteocyte for the nutritional ingredient provided in newborn mineral salt calcium source material under farnoquinone collective effect and ammonia sugar, chondroitin sulfate, it is deposited in the bone cavity that bone collagen is removed, is regenerated as new osteocyte；Utilization rate of replenishing the calcium is greatly improved, that unifies comprehensively realizes the good result replenished the calcium.
Description
Technical field：
The invention discloses a kind of colostrum mineral salt calcium-supplementing preparations, and invention further provides a kind of colostrum mineral salt systems of replenishing the calcium
The preparation method of agent, belongs to technical field of health care food.
Background technology：
It is many wide due to taking calcium crowd, so domestic and international market calcium is various in style mixed and disorderly, product mechanism is not up to the present seen also
Clear, the more perfect calcium product of product structure comes out in city.It is furtherd investigate to product structure, clinical trail and index of correlation
Test find：Current calcium product, which still has to replenish the calcium, to be absorbed and replenishes the calcium to the marrow, and absorptivity of replenishing the calcium is most of on 40% left side
The right side, the serious problems that skeletonization is utilized.It replenishes the calcium and is absorbed and be utilized problems demand and fundamentally solve！
Problems with urgently to be resolved hurrily：
1, to calcium raw material optimum choice；
2, the data great disparity between wanting the solution technology calculation amount of creativeness and now quantifying is poor；
3, existing calcium product filling into nutriment by osteocyte without fundamentally solution osteocyte needed nutrient matter
The synchronous dynamic of absorption balances.
It largely replenishes the calcium, the whole people's still calcium deficiency or even serious calcium deficiency have seriously affected the health of people.
Invention content：
The present invention provides a kind of colostrum mineral salt, and calcium raw material, ammonia sugar, chondroitin sulfate are mutually coordinated, complementary comprehensive, unified
Absorption of replenishing the calcium, the good result of skeletonization, strong bone to the marrow are realized, it is low to solve calcium absorptivity existing for traditional calcium-supplementing preparation,
The shortcomings such as effect difference.
Invention further provides a kind of preparation methods of colostrum mineral salt, at the beginning of being produced from whey as raw material using colostrum
Newborn mineral salt（Milk calcium）As novel calcium raw material, then with bone collagen, first milk basic protein, vitamine D3, vitamin
Whole the completing of K2, system is filled into and is adsorbed, the synchronous bidirectional dynamic equilibrium for absorbing and utilizing.
A kind of colostrum mineral salt calcium-supplementing preparation of the present invention, it is characterised in that be by following raw material by ratio of weight and the number of copies
It is manufactured：
400 ~ 600 parts of newborn mineral salt；40 ~ 60 parts of biological calcium carbonate；200 ~ 250 parts of bone collagen；First milk basic protein 20 ~
30 parts；100 ~ 150 parts of ammonia sugar；30 ~ 60 parts of chondroitin sulfate；30 ~ 60 parts of magnesium stearate；Vitamin D30.5-1.5 parts；Dimension life
Plain K20.25-1.0 parts.
A kind of colostrum mineral salt calcium-supplementing preparation of the present invention, it is characterised in that made by ratio of weight and the number of copies by following raw material
At：
500 parts of newborn mineral salt；50 parts of biological calcium carbonate；225 parts of bone collagen；First 25 parts of milk basic protein；Ammonia sugar 120
Part；40 parts of chondroitin sulfate；40 parts of magnesium stearate；Vitamin D31.0 part；Vitamin K20.7 part.
A kind of preparation method of colostrum mineral salt calcium-supplementing preparation of the present invention, includes the following steps：
1）The preparation of newborn mineral salt：
Concentration：
By colostrum under 60 degree of state of temperatures, negative pressure concentration volume is the 7%-10% of total amount；
Degreasing：
Concentration is added in colostrum after concentration as 0.5% carbonate, addition is concentrate colostrum 1%, stirring condition
Lower carry out degreasing；
Removal sugar and other invalid components are prepared into whey；
By whey ultrafiltration, pasteurize is carried out again；
Distillation, atomization, can be prepared into newborn mineral salt；
2）Mixing：
According to the above ratio by newborn mineral salt, biological calcium carbonate, bone collagen, first milk basic protein, ammonia sugar, chondroitin sulfate
Element, magnesium stearate, vitamin D3, vitamin K2It is mixed evenly；
3）Beat piece：
It is made according to conventional tablet manufacturing technique after above-mentioned material is sufficiently mixed uniformly（500-1000）Milli gram/piece
Agent；
4）Coating：
The tablet accomplished fluently is carried out rolling skeleton symbol using gelatin to be uniformly coated, coat weight（10-20）Milligram/every.
Key problems-solving of the present invention is：
1, the absorptivity of replenishing the calcium of all calcium products is most of 40% or so at present, and newborn mineral salt of the invention coordinates vitamin
D3 can be such that absorptivity doubles, and absorption hardly possible of replenishing the calcium is solved the problems, such as from basic.
2, the purpose of absorption of replenishing the calcium is to utilize, and is used in Psoralen, the utilization rate of current all calcium products is no more than inhaled
The 30% of yield such as mends the calcium that 600 milligrams of calcium only absorbs 240 milligrams, and skeletonization rate is replenished the calcium only at 70 milligrams so being not achieved
Desired effect.
The present invention is using targeting absorption and fills into form bi-directional synchronization dynamic equilibrium, realizes good skeletonization effect of replenishing the calcium
Fruit.
3, skeletonization of replenishing the calcium must satisfy the nutriment ingredient to form osteocyte, otherwise would not form sclerotin（Bone calcium）
Good effect of the present invention is：
1, the present invention uses novel technical matters, using colostrum as material, the newborn mineral salt produced（Milk calcium）For calcium raw material.
Contain the abundant required nutriment of formation osteocyte, such as zinc, magnesium, micro natural complex D in material, especially reaches
To the 2 of skeletonization:1 calcium-phosphorus ratio.Provide the material property that traditional calcium product does not have.
2, it based on the high-absorbility of calcium raw material, using lytic agent vitamin D as the solution absorption agent of calcium, fundamentally solves
It has determined absorption difficult problem.
3, making full use of new material, just milk basic protein can activate the adsorption activity of osteoblast, make to replenish the calcium to the marrow at
Bone, and complete to fill under the certain effect of carrier farnoquinone and be balanced with adsorption dynamics bi-directional synchronization, thoroughly solve benefit
Calcium solvent utilizes difficult problem.
4, harmonizing：
Ammonia sugar and bone collagen, the mutually coordinated complementation of chondroitin sulfate, fight osteoarthritis.It simultaneously can be effectively by articular cavity
In harmful substance and toxin dispose, therefore milk calcium+ammonia sugar adds chondroitin sulfate, bone collagen to be most preferably to arrange in pairs or groups, comprehensively
It conserves Bones and joints and repairs cartilaginous tissue.Ensure bone health.
5, comprehensive uniformity：
The present invention takes full advantage of newborn mineral salt（Milk calcium）The strong characteristic of own absorption ability, the suction that will replenish the calcium is cooperateed with vitamine D3
Yield increases substantially, and activates osteocyte for newborn mineral salt using first milk basic protein（Milk calcium）Provided in calcium source material
Nutritional ingredient is under farnoquinone collective effect and ammonia is sugared, chondroitin sulfate, under being deposited in the bone cavity that bone collagen is removed
Come, is regenerated as new osteocyte.Utilization rate of replenishing the calcium is greatly improved, that unifies comprehensively realizes the good result replenished the calcium.
【Adaptation population】：
Calcium health person, serious calcium deficiency and sclerotin disease, fracture patient；
Gout, cancer patient are a supporting role.
【Usage and dosage】：
Twice daily：Once in the morning and once at night, 1000-2000 milligrams each（1-2 pieces）, take orally or chew.
Breast mineral salt of the invention（Milk calcium）Mechanism explanation.
Calcium source material is the important link for determining product structure, especially component content, will be played to product efficacy important
Effect, and detection and determine the whether qualified standard of calcium product.
1, newborn mineral salt（Milk calcium）：
Newborn mineral salt is the manufactured best calcium source conducive to absorption of human body using whey as raw material；Its main component is phosphorous, magnesium, zinc,
Protein etc., calcium content is up to 28% ~ 30%；
Functional characteristic：
Calcium fortification function enhances bone density, reduces the incidence of other diseases；
The newborn maximum characteristic of mineral salt is absorptivity height of replenishing the calcium；
It is as follows that using human body simulation absorbing apparatus its result is detected through third party：
Calcium source material human body simulation absorbs data comparison table
| Serial number | Title material | Test result % | Remarks |
| 1 | Newborn mineral salt | 70 | |
| 2 | Calcium carbonate | 28 | |
| 3 | Calcium gluconate | 28 | |
| 4 | Calcium lactate | 40 | |
| 5 | Shell calcium | 13 |
As can be seen from the above table, under equal conditions, newborn mineral salt is 2.5 times higher than calcium carbonate absorptivity of replenishing the calcium, than grape acid
Calcium is 2.5 times high, 1.75 times higher than calcium lactate, 5.5 times higher than shell calcium.
As it can be seen that newborn mineral salt is human body to the absorbability optimal material of calcium considerably beyond current all calcium products
Absorption it is horizontal.
Using newborn mineral salt（Milk calcium）Have following two big advantages：
One：
Newborn mineral salt（Milk calcium）Containing the required all nutriments of osteoblast, especially 2 are formed in calcium source material:1
Calcium-phosphorus ratio is not available for current any calcium source material.
Secondly：
Newborn mineral salt（Milk calcium）Maximum advantage is the high-absorbility that calcium source material has, and fundamentally solves absorption of replenishing the calcium
Difficult problem；
Two above advantage is that we select newborn mineral salt（Milk calcium）The important evidence of calcium source material as the present invention.
2, vitamine D3:
Vitamine D3 is a kind of liposoluble vitamin, is sterol analog derivative；
Efficacy effect：
Vitamine D3 can be dissolved calcium by promoting duodenum and proximal jejunum to absorb calcium.Promote absorption of human body.
Vitamine D3 must be mended by replenishing the calcium, because vitamine D3 is the lytic agent of calcium；
But vitamine D3 day dosing is circumscribed, much can not meet the needs of technical indicator, since calcium source material solves
Absorptivity of replenishing the calcium low problem, the overall process for enabling vitamin D to participate in replenishing the calcium；
Therefore newborn mineral salt（Milk calcium）With the mutually coordinated complementation of vitamine D3, becomes in calcium product structure and most preferably arrange in pairs or groups；
Absorptivity of replenishing the calcium is measured using manikin simulating equipment can reach 90% or more through third party.
3, biological calcium carbonate：
Biological calcium carbonate is that oyster is made of raw material, its main feature is that natural safe calcium content is high；
Purposes：
In addition to as nutrition fortifier, alkaline agent is can be used as, the characteristics of according to biological calcium carbonate, is used for adjusting breast in prescription
Mineral salt（Milk calcium）Calcium content, while again as the present invention alkaline mediator agent；
Biological calcium carbonate matches with newborn mineral salt and complementation, and the calcium content of the present invention is made to reach 700 milligrams of day dosing or more, pH value
It adjusts between 7.5-7.8, keeps the auxiliary characteristics of the present invention more perfect.
4, bone collagen：
Many people think that caused by osteoporosis is calcium deficiency；
Bone collagen is one kind of collagen, has the fibrocyte manufacture in corium, it is distributed in human muscle and connects flesh
In tendon, in the cartilage group matter and the skin corium of connective group matter and skin of joint connection；
Efficacy effect：
Prevent and improve osteoporosis
Arthralgia is eliminated, is prevented, is mitigated arthroncus, is deformation, stiff；
Accelerating union of bone fracture improves bone toughness,
Calcium loss is prevented, calcium absorptivity is improved；
Bone collagen can promote deposition of the inanimate matters such as calcium, phosphorus on bone, thus can play reparation bone tissue, improve sclerotin and dredge
Loose shape promotes the effect of health.Therefore bone collagen is indispensable skeleton nutrition bonding agent during replenishing the calcium；
Many people think that osteoporosis is because caused by calcium deficiency, it is practical not so, be because lacking bone collagen, cannot jail
Jail the nutriment of osteocyte is glued together, causes to be lost in, also results in the loss of calcium, just form osteoporosis；
Since the loss of the required nutriment of osteocyte makes bone form cavity, to arthralgia, swelling；
The present invention has the action characteristic of adhesive using bone collagen, by newborn mineral salt（Milk calcium）Contained in calcium, phosphorus etc.
Nutriment is bonded together.It has repaired injured osteocyte and has promoted the power of regeneration of osteocyte；
So bone collagen is one of indispensable element of replenishing the calcium.Otherwise, the required nutrition of calcium and osteocyte filled into
Substance will be metabolized loss.
5, first milk basic protein：
First milk basic protein is the essence albumen extracted from colostrum.
Primary efficacy feature：
First milk basic protein passes through third-party testing, confirms that it has following features and function：
1, it is a kind of activated protein
2, osteoblastic proliferation can be promoted, greatly enhance it is calcareous be absorbed and utilized, keep bone density, can be done directly on bone
Cell promotes bone metabolism.
3, sclerotin is repaired, bone growth is promoted.
4, first milk basic protein, which can effectively improve bone and its cells and actively adsorb calcium and ossein etc., makes osteotrophy composition
Ability, be a kind of adsorption capacity be not supplementary function.
The purpose replenished the calcium is for Psoralen, and the purpose of Psoralen is to ensure the balance of serum calcium, this be a physiology transporting not
Reversible rule.
Due to the use limitation to farnoquinone, the demand of technical indicator is much can not meet as carrier to the marrow.So
It replenishes the calcium skeletonization to the marrow, at a great problem utilized of replenishing the calcium at present, and replenishes the calcium and do not obtain one of the basic reason of effect.
First milk basic protein activates bone and its cells, the nutritional ingredients such as calcium and bone collagen is actively adsorbed, with vitamin
K2's fills into effect, forms two-way dynamic equilibrium, greatly enhances to calcareous absorption and utilization.
Adsorbent using first milk basic protein as skeletonization to the marrow is that fundamentally solve the low difficulty of utilization rate of replenishing the calcium
Topic.
6, farnoquinone：
Farnoquinone is a kind of liposoluble vitamin, and the derivative of the naphthoquinones gene with phylloquinone bioactivity, is in human body
One of indispensable important vitamin.
The effect of farnoquinone：
1, sufficient farnoquinone activates osteogenic protein-osteocalcin, optimizes the absorption of calcium by its efficient catalytic action,
Operating, deposition and excretion, it is ensured that calcium increases bone density in the holding that is deposited on of bone.
2, farnoquinone can be transferred to the blood calcium in blood in bone, and deposition is got off, and become bone calcium.
So digestive function calcium can only be decomposed and with ion like cycle in blood, be exactly the blood calcium often said, blood calcium at
Free shape, can not be in Direct precipitation bone.
It can be seen that farnoquinone is the transfer agent for making blood calcium become bone calcium；
Since the required nutriment of osteocyte is transferred in bone by farnoquinone, farnoquinone is referred to as the load replenished the calcium
Body.
Due to farnoquinone, day limit dosing is it is therefore difficult to meet the needs of replenishing the calcium technical indicator no more than 100 micrograms
This hang-up is solved, present invention employs farnoquinone as during replenishing the calcium fills into carrier；Utilize colostrum alkalinity egg
It is white that adsorbent of replenishing the calcium, phase harmonizing is used as to form the two-way dynamic equilibrium filled into absorption, reached skeletonization to the marrow of replenishing the calcium
Good result.
It is known
Calcium deficiency and serious calcium deficiency and osteoporosis crowd, most of patient have rheumatism, arthritis and sclerotin disease, master
Reason is wanted there are following two aspects：
One：Lack bone synovia, joint hard friction causes periarticular red and swollen and arthralgia；
Secondly：Due to ossein loss and decalcification, causes the bone hole hole in bone cavity, corroded by inflammation and toxin, it is difficult to be made new
Raw bone cell proliferation；
Synchronization solution osteocyte regenerates, increases bone synovia, diminishes inflammation when only replenishing the calcium, toxin just can make newborn osteocyte firmly
It is bonded in bone hole hole；
So during replenishing the calcium, repair with proliferation must synchronous progress, it is not in all senses otherwise to replenish the calcium.
7, ammonia sugar：
Ammonia sugar is a kind of monosaccharide components, and full name is D- Glucosamines, be to form one of important nutrient of cartilage cell, and
The basis of cartilage matrix and joint fluid.
Effect and effect：
1, cartilage and immune link are repaired；
2, anti-inflammatory；
3, knuckle synovia is expedited the emergence of, repairs the articular cartilage being worn, and new articular cartilage and synovial membrane can be generated；
4, nourishing the bone promotes the conveying of nutriment and functional component；
5, ammonia sugar and collagen, chondroitin sulfate coordinate confrontation osteoarthritis；
Repairing is damaged synovial membrane and cartilage, is the important link for curing bone and joint diseases；
Therefore, bone collagen adds calcium, then ammoniates sugar and chondroitin sulfate, is the inflammation and toxin eliminated in bone hole hole, is section
It learns, reliable effectively collocation.
8, chondroitin sulfate：
Chondroitin sulfate is covalently attached on protein, and a kind of glycosaminoglycan of albumen ammonia sugar is formed.
Effect and effect：
The primary efficacy effect of chondroitin sulfate is used cooperatively with Glucosamine, is had analgesic, is promoted the work(of regenerating bone or cartilage
Effect, fundamentally improves joint prob.
It replenishes the calcium, is exactly to balance serum calcium for Psoralen, this is that the way of moving of calcium is also body from steady system, is that can not you
The physiology transporting process of reverse.
It replenishes the calcium and seeks to solve nutriment required for absorbing osteocyte, and fill into bone.
Replenishing the calcium, it is synchronous with osteocyte is repaired to be proliferated osteocyte.
Science of the present invention, rationally, safety it is perfect replenish the calcium during all links, comprehensively, unified forms one
It is a that there is good effect, the perfect product structure of effect.
9, magnesium stearate：
Magnesium stearate is the white easily fine powder without grittiness.
Purposes：Due to having good mobility and compressibility.It is used as glidant in direct tablet compressing；It is that novel medicinal is auxiliary
Material, can make the film coating material of solid pharmaceutical preparation, the thickener of Alternating Liquids preparation, suspension etc.；Magnesium stearate is in the present invention
Lubricant for beating piece.So not being described in detail herein.
The experiment of clinical effectiveness and bone density and contrast test report of the present invention：
One, diagnostic criteria
It is contained according to modern medicine, Natural medicine, nutrition：
Calcium deficiency crowd, weak, immunologic hypofunction；
Serious calcium deficiency crowd, suffers from arthritis, rheumatism etc., pain in low back and legs, easy catching a cold at fatigue.
Two, it is included in clinic：
Every above-mentioned symptom can carry out clinic.
Three, administration, dosing：
Administration：Oral, chewing
Dosing：
Twice daily：Once in the morning and once at night, every time 1000-2000 milligrams（1-2 pieces）
Four, efficacy criteria：
（One course for the treatment of 20 days）
Effectively：Calcium deficiency symptom makes moderate progress after taking a course for the treatment of.
It is effective：Calcium deficiency symptom takes an evident turn for the better after taking two courses for the treatment of.
Recovery from illness：After taking the 2-3 course for the treatment of, joint is strong, immunity enhancing, endurance.
In vain：The 1-2 course for the treatment of is taken to lose alleviation and improve symptom.
Five, clinical effectiveness counts：
Calcium deficiency person：12 people；Pain in low back and legs, weak, joint is heavy；Wherein：Fully recover 9 people, effective 3 people.
31 people of serious calcium deficiency person；Sclerotin disease：16 people；3 courses for the treatment of, 12 people of recovery from illness, effective 4 people.
Osteoporosis：11 people；3 courses for the treatment of, 5 people of recovery from illness, effective 6 people；
Fracture patient：4 people；3 course for the treatment of all healeds, can freely activity.
Clinical statistics are as follows：It is efficient：100%；Obvious effective rate：30%；Cure rate：70%；Inefficiency：Without display.
Index of correlation contrast table
Explanation：
1, it is not less than 600 milligrams by regulation calcium day dosing
2, solubility is the important guarantee absorbed
3, it replenishes the calcium for Psoralen, for Psoralen in order to balance serum calcium, one of important use of serum calcium is middle conjunction body acidic materials,
（PH value of human body is 7.35-7.45）So calcium product pH value has to be more than 7.5.
4, calcium-phosphorus ratio is the important component of Psoralen, it is necessary to be had, otherwise replenishing the calcium loses meaning.
Using the present invention, osteoporosis, bone density are tested, measuring correction data further proves, newborn mine
Object salt（Milk calcium）Possessed special efficacy effect.
Specific implementation mode：
A series of tool of detailed descriptions listed in each embodiment only for feasible embodiment of the present invention below
Body illustrates that they are all without departing from equivalent implementations made by essence of the invention not to limit the scope of the invention
Or change should all be included in the protection scope of the present invention.
The newborn minerals salt of embodiment 1；Biological calcium carbonate part；Bone collagen part；First milk basic protein part；Ammonia sugar
Part；Chondroitin sulfate part；Magnesium stearate part；Vitamin D3Part；Vitamin K2Part
1）The preparation of newborn mineral salt：
Concentration：
By colostrum under 60 degree of state of temperatures, negative pressure concentration volume is the 7% of total amount；
Degreasing：
Concentration is added in colostrum after concentration as 0.5% carbonate, addition is concentrate colostrum 1%, stirring condition
Lower carry out degreasing；
Removal sugar and other invalid components are prepared into whey；
By whey ultrafiltration, pasteurize is carried out again；
Distillation, atomization, can be prepared into newborn mineral salt；
2）Mixing：
By newborn mineral salt 500kg, 50 kg of biological calcium carbonate, 225 kg of bone collagen, 25 kg of first milk basic protein, ammonia sugar
120 kg, 40 kg of chondroitin sulfate, 40 kg of magnesium stearate, 1.0 kg vitamin Ds3, 0.7 kg vitamin Ks2It is mixed equal
It is even；
3）Beat piece：
It is made according to conventional tablet manufacturing technique after above-mentioned material is sufficiently mixed uniformly（500-1000）Milli gram/piece
Agent.
4）Coating：
The tablet accomplished fluently is carried out rolling skeleton symbol using the gelatin of concentration 40% to be uniformly coated, every 10-20 milligrams of coat weight.
5）It is packed after quality testing qualification as newborn mineral salt（Milk calcium）Finished product.
Embodiment 2
1）The preparation of newborn mineral salt：
Concentration：
By colostrum under 60 degree of state of temperatures, negative pressure concentration volume is the 10% of total amount；
Degreasing：
Concentration is added in colostrum after concentration as 0.5% carbonate, addition is concentrate colostrum 1%, stirring condition
Lower carry out degreasing；
Removal sugar and other invalid components are prepared into whey；
By whey ultrafiltration, pasteurize is carried out again；
Distillation, atomization, can be prepared into newborn mineral salt；
2）Mixing：
By newborn mineral salt 500kg, biological calcium carbonate 50kg, bone collagen 225kg, first milk basic protein 25kg, ammonia sugar
120kg, chondroitin sulfate 40kg, magnesium stearate 40kg, 1.0kg vitamin D3, 0.7kg vitamin Ks2It is mixed evenly；
3）Beat piece：
It is made according to conventional tablet manufacturing technique after above-mentioned material is sufficiently mixed uniformly（500-1000）Milli gram/piece
Agent.
Embodiment 3
1）The preparation of newborn mineral salt：
Concentration：
By colostrum under 60 degree of state of temperatures, negative pressure concentration volume is the 9% of total amount；
Degreasing：
Concentration is added in colostrum after concentration as 0.5% carbonate, addition is concentrate colostrum 1%, stirring condition
Lower carry out degreasing；
Removal sugar and other invalid components are prepared into whey；
By whey ultrafiltration, pasteurize is carried out again；
Distillation, atomization, can be prepared into newborn mineral salt；
2）Mixing：
By newborn mineral salt 600kg, biological calcium carbonate 60kg, bone collagen 250kg, first milk basic protein 30kg, ammonia sugar
150kg, chondroitin sulfate 60kg, magnesium stearate 60kg, 1.5kg vitamin D3, 1.0kg vitamin Ks2It is mixed evenly；
3）Beat piece：
It is made according to conventional tablet manufacturing technique after above-mentioned material is sufficiently mixed uniformly（500-1000）Milli gram/piece
Agent.
It is exemplified below model case, further proves effect effect of the present invention：
Medical record 1：Certain man, 49 years old
Master states：Foot is powerless on foot, and joint is loud, does work just feels to tire out, and the above situation had as long as half a year, was seen greatly to hospital
Husband, allow had some, what problem reinforcement nutrition do not check.
Physical examination：It does blood routine and trace element is examined：It was found that：Blood albumin is low, blood calcium value is less than the slight joints 2.25mmL
It is scorching.
It examines：Acalcicosis：
Treatment：1 product of the embodiment of the present invention is taken, it is 1 early（1000mg）Evening（Before sleeping）2（2000mg）It is checked after 40 days.
It is checked after 40 days：Strong on foot, spirit is full, and conventional and micro- blood calcium of having a blood test is 2.5mmol/L, is restored just
Often, it fully recovers.
Medical record 2：Certain female, 53 years old
Main suit：It feels run-down, feels very tired on foot, also bad, frequent twitch of getting up morning of sleeping, arthralgia is looked into again to hospital
Any disease is not gone out.
Physical examination：Blood routine, blood calcium, 2.15mmol/L, leg joint are beaten reactionless.It examines：Serious acalcicosis.
Treatment：2 product of the embodiment of the present invention is taken, it is 1 early（1000mg）Evening sleeps first 2（2000mg）, multiple after two months
It looks into.
It is checked after 3 courses for the treatment of：
Calcium value of having a blood test is 2.42mmol/L, and sleep is improved completely, and on foot effectively, twitch is fully recovered after taking 2 courses for the treatment of.
It is recommended that：Take health care amount, early, each 1 of evening.
Medical record 3：Certain man, 65 years old
Main suit：It is each arthralgia, numbness, gruelling on foot, it goes to hospital to see doctor, says it is rheumatism, eaten 3 years medicines, still
It is as usual, it is easy catching a cold, weak.
Physical examination：Blood calcium value 2.10mmol/L, swivel of hand deformation, are stretched not directly at redness.
It examines：Serious acalcicosis, osteoporosis, rheumatic arthritis.
Treatment：3 product of the embodiment of the present invention is taken, it is 2 early（1000mg×2）, evening sleeps first 2（1000mg×2）After 80 days
Check,（4 courses for the treatment of）.
Check：Conventional blood calcium of having a blood test is 2.35mmol/L, normal.
Redness and swelling of joints disappears, and can slowly restore normal, joint is strong, osteoporosis complete incidence graph.
The follow-up service after 5 courses for the treatment of of above-mentioned case, patient have fully recovered.
Claims (3)
1. a kind of colostrum mineral salt calcium-supplementing preparation, it is characterised in that be following raw material by ratio of weight and the number of copies made of：
400 ~ 600 parts of newborn mineral salt；40 ~ 60 parts of biological calcium carbonate；200 ~ 250 parts of bone collagen；First milk basic protein 20 ~
30 parts；100 ~ 150 parts of ammonia sugar；30 ~ 60 parts of chondroitin sulfate；30 ~ 60 parts of magnesium stearate；Vitamin D30.5-1.5 parts；Dimension life
Plain K20.25-1.0 parts.
2. a kind of colostrum mineral salt calcium-supplementing preparation as described in claim 1, it is characterised in that be by following raw material in parts by weight
Than manufactured：
500 parts of newborn mineral salt；50 parts of biological calcium carbonate；225 parts of bone collagen；First 25 parts of milk basic protein；Ammonia sugar 120
Part；40 parts of chondroitin sulfate；40 parts of magnesium stearate；Vitamin D31.0 part；Vitamin K20.7 part.
3. a kind of preparation method of colostrum mineral salt calcium-supplementing preparation as described in claim 1 or claim 2, including following step
Suddenly：
1）The preparation of newborn mineral salt：
Concentration：
By colostrum under 60 degree of state of temperatures, negative pressure concentration volume is the 7%-10% of total amount；
Degreasing：
Concentration is added in colostrum after concentration as 0.5% carbonate, addition is concentrate colostrum 1%, stirring condition
Lower carry out degreasing；
Removal sugar and other invalid components are prepared into whey；
By whey ultrafiltration, pasteurize is carried out again；
Distillation, atomization, can be prepared into newborn mineral salt；
2）Mixing：
According to the above ratio by newborn mineral salt, biological calcium carbonate, bone collagen, first milk basic protein, ammonia sugar, chondroitin sulfate
Element, magnesium stearate, vitamin D3, vitamin K2It is mixed evenly；
3）Beat piece：
It is made according to conventional tablet manufacturing technique after above-mentioned material is sufficiently mixed uniformly（500-1000）Milli gram/piece
Agent；
4）Coating：
The tablet accomplished fluently is carried out rolling skeleton symbol using gelatin to be uniformly coated, coat weight（10-20）Milligram/every.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111296577A (en) * | 2020-03-20 | 2020-06-19 | 湖南康诺优品健康产业有限公司 | Milk powder formula and preparation method |
| CN113349379A (en) * | 2021-06-29 | 2021-09-07 | 华纳盛世(武汉)生物科技有限公司 | Composition for improving bone health and preparation method thereof |
| CN113558247A (en) * | 2021-08-03 | 2021-10-29 | 汤臣倍健股份有限公司 | A method for preparing tablet containing high content of milk mineral salt |
| CN114343187A (en) * | 2021-12-27 | 2022-04-15 | 北京康比特体育科技股份有限公司 | Health beverage containing collagen tripeptide and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107969705A (en) * | 2017-11-29 | 2018-05-01 | 马艳艳 | A kind of just milk basic protein milk calcium piece and preparation method thereof |
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2018
- 2018-05-10 CN CN201810440537.8A patent/CN108720000B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107969705A (en) * | 2017-11-29 | 2018-05-01 | 马艳艳 | A kind of just milk basic protein milk calcium piece and preparation method thereof |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111296577A (en) * | 2020-03-20 | 2020-06-19 | 湖南康诺优品健康产业有限公司 | Milk powder formula and preparation method |
| CN113349379A (en) * | 2021-06-29 | 2021-09-07 | 华纳盛世(武汉)生物科技有限公司 | Composition for improving bone health and preparation method thereof |
| CN113558247A (en) * | 2021-08-03 | 2021-10-29 | 汤臣倍健股份有限公司 | A method for preparing tablet containing high content of milk mineral salt |
| CN113558247B (en) * | 2021-08-03 | 2022-05-31 | 汤臣倍健股份有限公司 | A method for preparing tablet containing high content of milk mineral salt |
| CN114343187A (en) * | 2021-12-27 | 2022-04-15 | 北京康比特体育科技股份有限公司 | Health beverage containing collagen tripeptide and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN108720000B (en) | 2019-08-06 |
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