RU2309751C1 - Method for treating the disorders of mineral metabolism at arthritis, or osteochondrosis, or rickets, or arthrosis, or osteoporosis - Google Patents

Abstract

FIELD: medicine, therapy.

SUBSTANCE: the present innovation deals with treating diseases associated with the affected mineral metabolism. So, during meals it is necessary to introduce daily perorally aqueous solutions of microelements salts for 20 d. In the morning one should apply the following composition: cobalt chloride 1.0-1.5 mg, manganese chloride 4.0-5.0 mg, zinc sulfate 4.5-5.5 mg, potassium iodide 0.8-1.5 mg, water - up to 1 ml. In the evening it is necessary to apply for the intake: copper sulfate 0.8-1.5 mg, water - up to 1 ml. These solutions should be introduced at the dosage of 1 ml/10 kg body weight being pre-dissolved in 50-100 ml water. Optimal quantitative and qualitative composition of microelements solutions leads to no side effects.

EFFECT: higher efficiency of therapy.

5 ex, 1 tbl

Description

The invention relates to medicine, in particular to bioelementology, in particular to microelementology, and can be used in the treatment and prevention of diseases with impaired mineral metabolism.

Diseases with impaired mineral metabolism (arthritis, osteoporosis of bone tissue, osteochondrosis, rickets, arthrosis, osteochondrosis) are an important social problem, since they are the most common in all age groups of the population.

One of the conditions for the normal existence of an organism is its relationship with the environment. The growth of negative changes in public health is due to the unfavorable ecological state of the environment. For three decades, scientists have been studying the migration of macro- and micronutrients in the food chain: source of pollution - soil - plants - animals - people. As a result of these disorders, a large part of the population suffers from metabolic disorders and, as a result, from a number of pathologies. The system "mother-placenta-fetus" in these regions leads to the birth of children with pathology of the immune system, suffering from dysbiosis, allergies, diseases with metabolic disorders.

The Biologically Active Additives of the Scientific Research Institute of Clinical Nutrition and New Technologies (NIILOP and NT) (ARGO Consumer Society) are known: Nutricon Green, the composition of the preparation includes: grain shells of wheat and rye, rose hips, vitamins of groups B, C, E , D, iodides, trace elements, etc. Nutricon Plus E: wheat germ, wheat bran, spirulina microalgae, trace elements (iron, magnesium, manganese, zinc). Nutricon Chrom: wheat and rye grain shells, oat in a grain shell, rose hips, nettle leaf, knotweed, B vitamins, ascorbic acid, essential amino acids, chromium and other trace elements. “Grace Cocktail”: soy protein isolate, dry lactose, fructose, 18 amino acids, B, A, C, E, D vitamins, biotin, folic and pantothenic acids, minerals and trace elements - calcium, phosphorus, potassium, iodine, iron, copper, zinc, etc. "Energy Cocktail": soy protein isolate, fructose, soy protein, B, A, C, E, D vitamins, biotin, minerals and trace elements - calcium, phosphorus, potassium, iodine, iron, zinc.

Products BIOLIT LLC, Tomsk offers “Achillan Granules”: a complex of highly active essential oils, betaine, polysaccharides, vitamins K, C, a complex of trace elements. Vitamix Granules: dry concentrated juices of beets, sea-buckthorn, cranberries, Altai flower honey, whey powder, microelements (iron, phosphorus, calcium, copper, magnesium, sulfur, potassium, cobalt, zinc, silicon, nickel, molybdenum, manganese) enzymes.

Dietary supplement manufactured by Nutri-Care, USA. CAL-D-MAG (CAL-D-MAG) includes: calcium carbonate, chelating compounds of calcium, magnesium, vitamins C, D, parsley, dandelion root, alfalfa, lactose, homeopathic preparations - calcium phosphate, calcium sulfate, magnesium phosphate, silicon oxide. Liver-Plus includes: lyophilized bull liver tissue, brown algae, dandelion root, B vitamins, homeopathic preparations - potassium chloride, calcium sulfate, magnesium phosphate, sodium sulfate, silicon oxide, zinc chelates , magnesium, calcium phosphate. Malti-complex (Multi-complex) - a highly effective formula that satisfies the daily requirement of men and women of any age, contains vitamins of groups B, A, C, E, chelate compounds of iron, calcium, silicon, magnesium, manganese, copper, selenium, chromium, zinc, homeopathic medicines (cell salts) - iron phosphate, potassium chloride, potassium phosphate, potassium sulfate, calcium phosphate.

The products of AD MEDICINE (Great Britain) are represented by Shugar-Balance products, which contain: vitamins B, A, C, D, calcium D-pantothenate, magnesium citrate, zinc citrate, manganese aspartate, chromium polynicotinate, potassium citrate, vanadium aspartate.

Zhey Deng Man produces Ruidemen - Healthy Bones capsules, which contain 15 mg of calcium carbonate, 95 mg of eggshell, 1.5 mg of isoflavone soy, 0.45 μg of vitamin D, trace elements and other natural ingredients, including including genestin, daidzin, medicinal plants, for example grass of a large-flowered goryanka (family of barberry).

A known method of treating diseases with impaired mineral metabolism of the Center for Biotic Medicine at hand. doctor of medical sciences Skalnogo A.V. with the help of the Health Spring products and the use of Bio-Manganese preparations, 1 capsule contains 12.5 mg of manganese asparaginate (2 mg of a microelement), Bio-Magnesium - 1 capsule contains 285 mg of magnesium asparaginate (20 mg of a macroelement), Bio-Zinc - 1 capsule contains 18 mg of zinc asparaginate (5 mg of microelement), Bio-Potassium - 1 capsule contains 300 mg of potassium asparaginate (10 mg of macrocell), Bio-Copper - 1 capsule contains 7 mg of asparaginate copper (2 mg of microelement), Selenochel - 1 capsule / tablet contains 200 mg of selenium-containing yeast autolysate (50 μg in the form of selenium and selenium-methionine-cysteine), "Hromohel" - 1 capsule / tablet contains 1 mg chromium asparaginate (111) (100 g trace element). The above drugs are recommended for adults and children over 12 years of age, 1-2 capsules / tablets per day after meals.

Tianshi Corporation Dietary Supplements (TIANSHI) are widely used on the market. They are represented by Biocinz, which includes zinc lactate, dosage for children 3-10 years old to 2 capsules 2 times a day, over 10 years old and adults up to 4 capsules 2 times a day, select duration individually. “Spirulina tablets” - 100 g contains 60-70 g of protein, which are absorbed by the human body up to 65-80%, contain 18 amino acids necessary for a person, 8 of them are irreplaceable, not synthesized by the body, macro and microelements: iron, calcium, copper , magnesium, manganese, zinc, phosphorus, selenium, a large number of vitamins.

Indications: prevention and treatment of joint diseases, osteochondrosis, growth stimulation in adolescence, acceleration of the healing process for injuries and fractures.

The main disadvantage of treatment methods using biologically active additives is their high cost, in addition, they contain components that, being in the same preparation, often turn out to be antagonists to each other (zinc and copper), which is often complicated by the appearance of allergic reactions and, in turn, treatment time is lengthening.

Known biologically active food supplement described in the patent for the invention of Russia No. 2156087, published September 20, 2000, containing lithium, potassium, magnesium, iron, zinc, copper, manganese, nickel, boron, cobalt, molybdenum, vanadium, fluorine, glycine, ascorbic acid, iodine, nicotinamide, nicotinic acid, thiamine, riboflavin, calcium pantothenate, pirodoksin, tsiankobalomin, calcium pangamate, tocopherol, folic acid, retinol, ergokaliferol, cholecalciferol, phytomenadione, adenosine acid, glutamic acid, mexidol distilled water nnuyu in a certain percentage.

This biologically active supplement can be used for rational and preventive nutrition in various extreme conditions and pathological conditions associated with a deficiency of irreplaceable vital trace elements and vitamins.

The disadvantage of this additive is that it is very complex and has a high cost, in addition, the additive contains components that, being in the same preparation, are often antagonists to each other (zinc and copper, copper and molybdenum, manganese and iron, nickel and cobalt). And sometimes incompatibility among vitamins is also observed, which is often complicated by the appearance of allergic reactions and as a result a small therapeutic effect.

The known method of A.A. Kabysh for the prevention of endemic osteodystrophy in cattle, described in the patent for the invention of Russia No. 2250029, published on November 27, 2004. The method includes replenishing the feed ration of cattle with microelements: salts of cobalt chloride 0.02-0.5 mg , manganese chloride 0.05-1.0 mg and potassium iodide 0.002-0.02 mg, water up to 1 ml per 1 kg of live weight 1 time per day for 30-60 days and 30-60 days off.

The invention relates to agriculture for the prevention and treatment of cattle. The proposed method of treatment is simple. However, the disadvantage of this treatment is the long treatment period of 30-60 days, twice with an interval of 30-60 days, in addition, this method of treating a person is not well understood.

The closest analogue, selected as a prototype, is a method for the treatment of rheumatoid arthritis, described in the patent for the invention of Russia No. 2182006, published December 27, 2001, which consists in the introduction of 20 ml of an aqueous solution of salts into the body within 1-3 months every other day trace elements in a concentration of μg / g - copper 300-1000, zinc 50-100, indium 5-10, cobalt 3-5, manganese 10-50, chromium 0.05-0.1, silicon 2000-5000. Copper, zinc, indium, cobalt, manganese, chromium are introduced in the form of chlorides, and silicon in the form of sodium silicate or potassium and, in addition, the joints are moistened 2-3 times a day for 1-3 months. This drug is known in medicine as “Esvitsin”, previously used to prevent baldness and general healing of a person.

The proposed method of treatment is expensive, since the composition of the drug includes rare earth metals, and has a long treatment period of 1-3 months, with exacerbations, repeated use is mandatory, in addition, components that, when in the same preparation, are often antagonists to each other (zinc and copper), which is often complicated by the appearance of allergic reactions and, in turn, the treatment time is extended.

The technical result of the invention consists in eliminating the indicated disadvantages of the prototype, namely, in a method for treating mineral metabolism disorders in arthritis, or osteochondrosis, or rickets, or arthrosis, or osteoporosis of bone tissue with reduced treatment time from 30-90 days to 20 days in the present invention and with a decrease in the cost of treatment by 2.6 times compared with the prototype.

The technical result is achieved by the fact that in the method of treating mineral metabolic disorders with arthritis, or osteochondrosis, or rickets, or arthrosis, or osteoporosis of bone tissue, comprising daily administration of an aqueous solution of trace elements salts, according to the invention, during a meal for 20 days, the following are administered:

in the morning:

cobalt chloride 1.0-1.5 mg;

manganese chloride 4.0-5.0 mg;

zinc sulfate 4.5-5.5 mg;

potassium iodide 0.8-1.5 mg;

water up to 1 ml,

in the evening:

copper sulfate 0.8-1.5 mg;

water up to 1 ml

at the rate of 1 ml per 10 kg of weight, previously diluted in 50-100 ml of water.

Due to the fact that microelements are administered daily during meals, for 20 days at the rate of 1 ml per 10 kg of weight, previously diluted in 50-100 ml of water, in the morning cobalt chloride 1.0-1.5 mg, manganese chloride 4, 0-5.0 mg, zinc sulfate 4.5-5.5 mg, potassium iodide 0.8-1.5 mg, water up to 1 ml, in the evening - copper sulfate 0.8-1.5 mg, water up to 1 ml, reduce treatment time from 30-90 days in the prototype to 20 days in the present invention and reduce the cost of treatment by 2.6 times compared to the prototype.

The inventive method of treating disorders of mineral metabolism in arthritis, or osteochondrosis, or rickets, or arthrosis, or osteoporosis of bone tissue has a novelty compared to the prototype, differs from it by the listed features and ensures the achievement of the technical result perceived by the applicant.

The set of essential features of the proposed method does not follow explicitly from the studied prior art, i.e. meets the criteria of "novelty" and "inventive step".

The claimed method will find wide application in the treatment of patients, i.e. is industrially applicable.

The invention is illustrated as follows.

Mineral metabolism is normalized through the use of trace elements salts: cobalt of 6-water chloride, ChDA (GOST 4525-77) - 1.0-1.5 mg, 4-water manganese chloride, H (GOST 612-75) - 4.0 -5.0 mg, zinc sulfate 7-aqueous, ChP (GOST 4174-77) - 4.5-5.5 mg, potassium iodine, PSA (GOST 4232-74) - 0.8-1.5 mg, copper 5-aqueous sulfate, PSA (GOST 4165-78) - 0.8-1.5 mg.

The increase in the weight quantity of cobalt in this case is due to its participation in the processes of blocking and utilization of toxic elements, participation in enzymatic processes and the formation of thyroid hormones, normalization of mineral, protein, carbohydrate and fat metabolism.

An increase in the weight amount of manganese helps to prevent degenerative changes in the joints, reduce autoimmune and allergic reactions, normal functioning of muscle tissue, and remove inflammatory processes in it, shortening the treatment time.

The increase in the weight amount of potassium iodide is primarily associated with its participation in mineral and water-electrolyte metabolism, the regulation of protein and fat metabolism, and the restoration of thyroid function. Manganese enhances metabolic processes with less formation of compounds that adversely affect the body.

The additional introduction of copper in the treatment of diseases of the musculoskeletal system in our case is due to its participation in bone mineralization processes, participation in the production of thyroid hormones, anti-inflammatory and immunostimulating properties. Copper is necessary for the normal development of the skeleton. With copper deficiency, collagen synthesis is disrupted and soluble collagen (tropocollagen) predominates in the bone tissue, which is accompanied by increased fragility and deformation of bones. A lack of copper leads to the development of osteodystrophy and rickets.

Zinc is involved in bone calcification, protein and carbohydrate metabolism, and boosts immunity. Zinc deficiency is accompanied by regidity, joint swelling and lameness, and a decrease in the size and strength of the femur. Zinc deficiency inhibits alkaline phosphatase in chondrocytes of the epiphyseal cartilage, which is the main biochemical defect in the development of bone tissue.

The number of therapeutic and prophylactic solutions may vary depending on the biochemical and spectral analysis of the patient's urine. It is possible to combine several salts of trace elements in one step, taking into account the antagonism and synergism between these components (for example: cobalt, manganese, zinc and iodine salts can be used together, and copper separately with an interval of 8-10 hours).

The proposed solutions of trace elements are simple to use and can be used in the treatment and prevention of diseases with mineral metabolism disorders individually and as adjuvants in the treatment of diseases such as arthritis, or osteochondrosis, or rickets, or arthrosis, or osteoporosis of bone tissue

The study included 40 patients with bone pathology aged 12 to 56 years.

Recovery time as a result of the treatment.

Table 1 Group The number of people in the group Preparations Recovery time, days Control 8 Basic therapy - anti-inflammatory drugs, vitamins, calcium, magnesium, electrotherapy, massage, hormone therapy (in severe cases) - 1 experienced 8 Basic therapy and "Spirulina Tablets" 1 tablet 3 times a day, drink at least 1 glass of warm water. Take between meals. 40-60 2 experienced 8 Basic therapy and solutions of salts of trace elements cobalt, manganese, iodine 1 time per day for 30-60 days 30-60 3 experienced 8 Basic therapy and Esvitsin (copper, zinc, indium, cobalt, manganese, chromium) 20 ml every other day for 1-3 months 30-90 4 experienced 8 Basic therapy and solutions of salts of trace elements: cobalt, manganese, zinc and iodine in the morning with food for 20 days; copper - in the evening for 20 days at a dose of 1 ml per 10 kg of weight twenty

Anti-inflammatory drugs, vitamins, calcium and magnesium preparations, electrotherapy, massage, and in more severe cases hormone therapy were used as the basic therapy in the control group.

The first experimental group (n = 8), in addition to the basic therapy, received Spirulina Pills, 1 tablet 3 times a day for 60 days.

Patients of the 2nd experimental group (n = 8) in addition to the basic therapy received salts of trace elements: cobalt chloride, manganese chloride and potassium iodide, 1 time per day for 60 days.

The third experimental group (n = 8), in addition to the basic therapy, received the Esvitsin preparation (copper, zinc, indium, cobalt, manganese, chromium) in 20 ml every other day for 1-3 months (the cost of treatment per course is 800 rubles) .

Patients of the 4 experimental group (n = 8) in addition to basic therapy received microelement solutions: cobalt chloride, manganese chloride, zinc sulfate, potassium iodine and copper sulfate (the cost of treatment for a course of 300 rubles).

Solutions of salts of cobalt, manganese, zinc and iodine were given simultaneously in the morning for 20 days, copper in the evening for 20 days at the rate of 1 ml per 10 kg of body weight during meals, previously diluted in 50-100 ml of water.

As a result of the treatment, it was ascertained that the most painful part of the bone tissue decreased and completely disappeared on day 20 in the fourth group, where, in addition to the basic therapy, salts of trace elements (cobalt, manganese, zinc, iodine and copper) were prescribed.

In the second and third experimental groups, pain remained until 30-40 days, then gradually decreased, but appeared in most patients with physical exertion or after 2-4 months.

In the first control group, we noted a gradual decrease in soreness by 40-60 days and the appearance of relapses after 1-3 months.

The clinical manifestations of the disease correspond to changes in some laboratory data presented in table 2, on the 1st, 10th and 30th day.

Analysis of the morphological composition of the blood (table 2) before treatment showed that in patients with impaired mineral metabolism in the blood, the content of red blood cells and the number of leukocytes at the upper limit of the norm are slightly increased. The above-mentioned deviations are associated with blood clotting as a result of intoxication of the body.

Changes in the leukoformula at the beginning of the experiment were characterized by an increase in the number of stab neutrophils by 34.8% of the normative data against the background of a decrease in segmented neutrophils and lymphocytes. These changes indicate tension of lymphopoiesis and a decrease in the activity of the cellular component of the immune system, since the increase in leukocytes is due to stab neutrophils, which have weak functional activity.

On the 10th day of the treatment, a gradual normalization of hematological parameters was observed. There was a decrease in the amount of hemoglobin in the 1st and 2nd experimental groups, respectively, by 2.8% and 6.7%, and the control - 0.7% (P <0.5). The noted deviations indicate a decrease in intoxication in the body of patients with impaired mineral metabolism, and in the 4th experimental group, where micronutrient salts were used, these deviations were more pronounced. On day 20, changes in the blood were similar. The level of basophils in the experimental and control groups was within the normative indicators and did not have significant differences between the groups, so it is not shown in table 2.

Spectral analysis of urine performed at the beginning, on the 10th and 20th day of treatment in the control and experimental groups showed a decrease in calcium excretion in the 1st experimental group by 2.1 times, in the 2nd - 1.5, in the 3rd - 2.6 and in the 4th - 3.9 times against the background of a slight decrease in the control group. Similar changes were noted in the elimination of phosphorus and magnesium (the research results are presented in table 3).

Thus, the proposed composition of trace elements in the form of aqueous solutions, consisting of cobalt, manganese, zinc, iodine and copper salts, lowers the renal threshold and promotes the absorption of calcium, magnesium and phosphorus by the body, the inclusion of these elements in metabolic processes and deposition in bone tissue.

The content of cobalt, manganese, zinc and copper in the urine increased and by day 20 it approached the normative data amid increased excretion of toxic elements - chromium, cadmium and nickel - from the body.

An example of a specific implementation No. 1.

A 52-year-old woman in mid-2004 had pain during movement and when climbing stairs in the left hip joint. He was diagnosed with arthritis of the left hip joint. The woman went to the doctors. During 6 months of 2004, the patient received anti-inflammatory drugs (gentamicin, benzylpenicillin sodium salt, prednisone, hydrocortisone), vitamins, calcium, magnesium, electrotherapy, massage. After the course of treatment, the pain subsided briefly (for two weeks), but then resumed with the same strength. The patient was immediately offered to undergo treatment in group 4 with microelement solutions: cobalt, manganese, zinc, iodine in the morning with meals for 20 days; copper - in the evening for 20 days at a dose of 1 ml per 10 kg of weight. The patient's weight is 71 kg, in the morning during the meal the patient received 7 ml based on: cobalt chloride 1.25 mg, manganese chloride 4.5 mg, zinc sulfate 5.5 mg, potassium iodide 1.15 mg, water 1 ml. In the evening, during a meal, the patient received 7 ml of the solution at the rate of: copper sulfate 1.15 mg, water 1 ml. The treatment ended in February 2005 and today - January 2006, the patient did not complain of pain.

An example of a specific implementation No. 2.

A teenager of 14 years, in 2004 there was pain in the lumbar spine. He was diagnosed with osteochondrosis. And treatment is offered. The patient received anti-inflammatory drugs (gentamicin, benzylpenicillin sodium salt, prednisone, hydrocortisone), vitamins, calcium, magnesium, electrotherapy, massage, and therapeutic exercises. After the first treatment, the pain subsided briefly, but after two months resumed with the same strength. Especially under load. The patient was offered to undergo treatment in group 4 with solutions of salts of trace elements: cobalt, manganese, zinc and iodine in the morning with food during 20 days; copper - in the evening for 20 days at a dose of 1 ml per 10 kg of weight. The patient’s weight is 53 kg; in the morning during a meal, the patient received 5 ml of a solution based on: cobalt chloride 1.0 mg, manganese chloride 4.0 mg, zinc sulfate 4.5 mg, potassium iodide 0.8 mg, water 1 ml. In the evening, while eating, the patient received 5 ml of the solution at the rate of: copper sulfate 0.8 mg, water 1 ml. The treatment ended in February 2005 and today - January 2006 the patient did not complain of pain.

An example of a specific implementation No. 3.

A 3-year-old patient, at the beginning of 2005, growth retardation, thickening of the knee joints, and chest deformation were observed. Was diagnosed with rickets. Treatment suggested. The patient received herbal tea (hops, oregano, succession, calendula, wild rose), massage, mud therapy, physical therapy, manual therapy, non-steroidal anti-inflammatory drugs, vitamins A, D. After the treatment, there was no improvement, the external indicators of the disease remained without visible changes and the patient offered to undergo treatment in group 4 with solutions of salts of trace elements: cobalt, manganese, zinc and iodine in the morning with food during 20 days; copper - in the evening for 20 days at a dose of 1 ml per 10 kg of weight. The patient’s weight is 20 kg, in the morning during a meal the patient received 2 ml of a solution based on: cobalt chloride 1.0 mg, manganese chloride 5 mg, zinc sulfate 5 mg, potassium iodide 1.0 mg, water 1 ml. In the evening, while eating, the patient received 2 ml of the solution at the rate of: 0.9 mg copper sulfate, 1 ml of water, the treatment ended in April 2005 and today - January 2006, the patient’s chest got a natural shape, the knee joints decreased, increased body weight and baby weight.

An example of a specific implementation No. 4.

A 60-year-old patient, in 2005 there was pain during movement, and then at rest in the right hip joint, lameness, aggravated by exertion. The diagnosis was arthrosis. The proposed treatment: the drug DONA, glucosamine sulfate, UHF, EF calcium and phosphorus, paraffin, multivitamins, aloe. After the treatment, the pain subsided slightly, but after 30 days an exacerbation occurred. The patient was offered to undergo treatment in group 4 with solutions of salts of trace elements: cobalt, manganese, zinc and iodine in the morning with food during 20 days; copper - in the evening for 20 days at a dose of 1 ml per 10 kg of weight. The patient's weight is 98 kg, in the morning during the meal the patient received 10 ml of the solution based on: cobalt chloride 1.2 mg, manganese chloride 5 mg, zinc sulfate 5.5 mg, potassium iodide - 0.8 mg, water 1 ml. In the evening, during a meal, the patient received 8 ml of the solution at the rate of: copper sulfate 1.0 mg, water 1 ml, the treatment ended in April 2005 and today - February 2006, the patient did not complain of pain.

An example of a specific implementation No. 5.

Patient 36 years old, in 2005 there was pain in the hip, knee joints and shoulder girdle, stiffness and pain during movement, lameness. He was diagnosed with osteoporosis of bone tissue. The proposed treatment: butadion, multivitamins, non-steroidal anti-inflammatory drugs, paraffin, ozokerite, calcium, magnesium. After the treatment, there was a slight improvement, after which the patient was asked to undergo treatment in 4 groups with solutions of salts of trace elements: cobalt, manganese, zinc and iodine in the morning with food during 20 days; copper - in the evening for 20 days at a dose of 1 ml per 10 kg of weight. The patient’s weight is 69 kg, in the morning during the meal the patient received 7 ml of the solution based on: cobalt chloride 1.0 mg, manganese chloride 4.5 mg, zinc sulfate 5.0 mg, potassium iodide 0.8 mg, water 1 ml. In the evening, while eating, the patient received 7 ml of the solution at the rate of: copper sulfate 1.0 mg, water 1 ml, the treatment ended in March 2005 and today - January 2006, the patient did not complain of pain.

The proposed method for the treatment of mineral metabolic disorders reduces the treatment time from 30-90 days in the prototype to 20 days in the present invention and reduces the cost of treatment by 2.6 times compared with the prototype, due to the fact that microelements are administered daily during meals for 20 days at the rate of 1 ml per 10 kg of weight, previously diluted in 50-100 ml of water, in the morning - cobalt chloride 1.0-1.5 mg, manganese chloride 4.0-5.0 mg, zinc sulfate 4.5-5 , 5 mg, potassium iodide 0.8-1.5 mg, water up to 1 ml, in the evening - copper sulfate 0.8-1.5 mg, water up to 1 ml.

Claims (1)

A method for the treatment of mineral metabolism disorders in arthritis, or osteochondrosis, or rickets, or arthrosis, or osteoporosis of bone tissue, comprising daily administration of an aqueous solution of trace elements salts, characterized in that during a meal for 20 days is administered in the morning: cobalt chloride 1.0 -1.5 mg, manganese chloride 4.0-5.0 mg, zinc sulfate 4.5-5.5 mg, potassium iodide 0.8-1.5 mg, water up to 1 ml, in the evening: copper sulfate 0, 8-1.5 mg, water up to 1 ml at the rate of 1 ml per 10 kg of weight, previously diluted in 50-100 ml of water.