WO2010044689A3 - Integrated screening methods for identifying modulators of mineralization, and modulators identified therefrom - Google Patents

Integrated screening methods for identifying modulators of mineralization, and modulators identified therefrom Download PDF

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Publication number
WO2010044689A3
WO2010044689A3 PCT/PT2009/000054 PT2009000054W WO2010044689A3 WO 2010044689 A3 WO2010044689 A3 WO 2010044689A3 PT 2009000054 W PT2009000054 W PT 2009000054W WO 2010044689 A3 WO2010044689 A3 WO 2010044689A3
Authority
WO
WIPO (PCT)
Prior art keywords
modulators
mineralization
screening methods
identifying
identified therefrom
Prior art date
Application number
PCT/PT2009/000054
Other languages
French (fr)
Other versions
WO2010044689A2 (en
Inventor
Maria Leonor Quintais Cancela Da Fonseca
Paulo Jorge Travessa Gavaia
Vincent Stéphane Eric LAIZÉ
Anabela Ben-Simon Brito
Original Assignee
Technophage, Investigação E Desenvolvimento Em Biotecnologia, Sa
Universidade Do Algarve
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Technophage, Investigação E Desenvolvimento Em Biotecnologia, Sa, Universidade Do Algarve filed Critical Technophage, Investigação E Desenvolvimento Em Biotecnologia, Sa
Publication of WO2010044689A2 publication Critical patent/WO2010044689A2/en
Publication of WO2010044689A3 publication Critical patent/WO2010044689A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5085—Supracellular entities, e.g. tissue, organisms of invertebrates

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The invention relates, in some aspects, to methods for identifying modulators of mineralization. In other aspects, the invention relates to modulators of mineralization identified using the methods disclosed herein.
PCT/PT2009/000054 2008-10-16 2009-10-16 Integrated screening methods for identifying modulators of mineralization, and modulators identified therefrom WO2010044689A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10597508P 2008-10-16 2008-10-16
US61/105,975 2008-10-16

Publications (2)

Publication Number Publication Date
WO2010044689A2 WO2010044689A2 (en) 2010-04-22
WO2010044689A3 true WO2010044689A3 (en) 2010-06-10

Family

ID=41396459

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/PT2009/000054 WO2010044689A2 (en) 2008-10-16 2009-10-16 Integrated screening methods for identifying modulators of mineralization, and modulators identified therefrom

Country Status (1)

Country Link
WO (1) WO2010044689A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103063630B (en) * 2012-12-19 2016-03-30 山东省科学院生物研究所 A kind of screening system affecting mineralization of skeleton drugs with function
CN105899950B (en) * 2013-12-19 2017-11-24 根特大学 In fish scale as the biomarker for chronic stress glucocorticoid quantization

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2250029C2 (en) * 2003-05-08 2005-04-20 Кабыш Андрей Александрович Method for preventing endemic osteodystrophy in cattle
WO2005103694A2 (en) * 2004-04-26 2005-11-03 Daniolabs Limited Methods and fish models for identifying agents for treating bone and joint disease
RU2309751C1 (en) * 2006-02-07 2007-11-10 Татьяна Анатольевна Шепелева Method for treating the disorders of mineral metabolism at arthritis, or osteochondrosis, or rickets, or arthrosis, or osteoporosis

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2250029C2 (en) * 2003-05-08 2005-04-20 Кабыш Андрей Александрович Method for preventing endemic osteodystrophy in cattle
WO2005103694A2 (en) * 2004-04-26 2005-11-03 Daniolabs Limited Methods and fish models for identifying agents for treating bone and joint disease
RU2309751C1 (en) * 2006-02-07 2007-11-10 Татьяна Анатольевна Шепелева Method for treating the disorders of mineral metabolism at arthritis, or osteochondrosis, or rickets, or arthrosis, or osteoporosis

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
AKIMENKO MARIE-ANDREE ET AL: "Old questions, new tools, and some answers to the mystery of fin regeneration.", DEVELOPMENTAL DYNAMICS, vol. 226, no. 2, February 2003 (2003-02-01), pages 190 - 201, XP002560271, ISSN: 1058-8388 *
BIRD NATHAN C ET AL: "Developmental morphology of the axial skeleton of the zebrafish, Danio rerio (Ostariophysi: Cyprinidae).", DEVELOPMENTAL DYNAMICS, vol. 228, no. 3, November 2003 (2003-11-01), pages 337 - 357, XP002560273, ISSN: 1058-8388 *
DANIEL M TIAGO ET AL: "Impairment of mineralization by metavanadate and decavanadate solutions in a fish bone-derived cell line", CELL BIOLOGY AND TOXICOLOGY, KLUWER ACADEMIC PUBLISHERS, DO, vol. 24, no. 3, 25 September 2007 (2007-09-25), pages 253 - 263, XP019601450, ISSN: 1573-6822 *
QUINT ELIZABETH ET AL: "Bone patterning is altered in the regenerating zebrafish caudal fin after ectopic expression of sonic hedgehog and bmp2b or exposure to cyclopamine", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 99, no. 13, 25 June 2002 (2002-06-25), pages 8713 - 8718, XP002560272, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
WO2010044689A2 (en) 2010-04-22

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