CN101268835A - Nutrition high calcium medicinal granule for children and preparing technique - Google Patents

Abstract

The invention aims to provide a child nutritious high calcium medicinal granule and the production and manufacturing technology thereof. The child nutritious high calcium medicinal granule includes zymohydrolysis bone powder, tuckahoe extractive, whole milk powder, oligose, casein phosphoric acid peptide, dried egg yolk, 2-aminoethanesulfonic acid, sweetening agent, vitamin and mineral composition. The calcium medicinal granule obviously improves the absorptivity of calcium compared with the like product, is particularly suitable for being taken by children; the production and manufacturing technology is as follows: the zymohydrolysis bone powder is fully crushed and mixed with the tuckahoe extractive, so as to fully absorb axunge and phlegm which go against to be smashed, thereby being suitable for a gas stream type super micron milling technic to obtain calcium source fine powder, the technical condition is stable, thereby being suitable for manufacturing production of scale.

Description

A kind of child form nutritious rich-calcium electuary and production process thereof

(1) technical field:

The present invention relates to a kind of electuary and production process thereof, particularly a kind of child form nutritious rich-calcium electuary and production process thereof.

(2) background technology:

Sufficient calcium nutrition not only can promote growth of children, and extremely important to the integrality and the healthy growth of bone.The accumulation of bone amount mainly occurs in the youngsters and children phase, it be directly connected to growing of children and grow up after the peak bone amount, from being born to puberty, the bone amount has increased about 7 times, wherein calcium salt most importantly.Chinese children dietary calcium intake deficiency, add that China's meals constitute based on cereal, beans and bean product are less, and the vegetables intake is bigger, phytic acid and plant cellulose intake are higher relatively, make original calcium intake with regard to low Chinese children, and calcium absorbs and is affected, thereby further influence calcium nutrition, cause the Chinese children rickets incidence of disease higher relatively relatively low with the bone amount.

The fineness in calcium source influences the absorption of human body to calcium to a great extent, and the calcium source of superfine powder can increase calcareous specific area, promotes calcareous absorption, can obtain better effect with less taking dose.Superfine communication technique is an international new developing technology over nearly 20 years.So-called ultramicro grinding is meant that utilizing machinery or hydrokinetic method to overcome solid interior cohesiveness makes it broken.Be widely used in Chinese medicine and food processing field in recent years.Ox bone because of fat, protein content is high, when using micronizer to pulverize, difficult feed, crush efficiency are low, and it is still bigger to pulverize the back particle, fineness is about 300 orders, so present stage still can not successfully be applied to superfine communication technique to pulverize ox bone.

At the present situation of Chinese children intake, invent a kind of at children taking, calcium content is higher and calcium absorptivity is higher, simultaneously can promote the health food of upgrowth and development of children just to become the major issue that present stage needs to be resolved hurrily.

(3) summary of the invention:

The object of the present invention is to provide a kind of child form nutritious rich-calcium electuary and production process thereof; described child form nutritious rich-calcium electuary calcium absorptivity obviously improves than like product; be particularly useful for children taking; its production process is pulverized the enzymolysis bovine bone powder, mix through abundant with tuckahoe extracts; wherein be unfavorable for grease and the mucilaginous substance pulverized with abundant absorption; make it go for air-flowing type ultramicro grinding technology and obtain calcium source fine powder; used stable process conditions is fit to large-scale industrial production.

Technical scheme of the present invention: a kind of child form nutritious rich-calcium electuary; it is characterized in that comprising enzymolysis bovine bone powder, tuckahoe extracts, whole milk powder, compound sugar, CPP, yolk powder, taurine, sweetener, vitamin and mineral matter, its weight quota is than being enzymolysis bovine bone powder 18～21: tuckahoe extracts 2.0-3.0: whole milk powder 50～55: compound sugar 10～20: CPP 4～6: yolk powder 2～4: taurine 0.1-0.2: sweetener 0.3～0.5: vitamin 0.7～0.9: mineral matter 0.7～0.9.

Above-mentioned child form nutritious rich-calcium electuary is characterized in that vitamin comprises a kind of or its combination among VA, VB1, VB2, VB6, VC, the VD.

Above-mentioned child form nutritious rich-calcium electuary is characterized in that vitamin comprises a kind of or its combination among VC and the VD.

Above-mentioned child form nutritious rich-calcium electuary is characterized in that mineral matter comprises a kind of or its combination in zinc, iron, iodine, manganese, the magnesium.

Above-mentioned child form nutritious rich-calcium electuary is characterized in that mineral matter comprises a kind of or its combination in zinc and the iodine.

The production process of above-mentioned child form nutritious rich-calcium electuary is characterized in that may further comprise the steps:

(1) uses Universalpulverizer that tuckahoe extracts is ground into fine powder, cross the 60-100 eye mesh screen; Tuckahoe extracts fine powder, enzymolysis bovine bone powder are put in the trough type mixing machine, mixed 20-30 minute; Use Universalpulverizer to pulverize once in this mixture, wherein be unfavorable for grease and the mucilaginous substance pulverized not making it to adhere to micronizer inwall and pipeline with abundant absorption; Place micronizer to pulverize in the mixture after the above-mentioned pulverizing, compressed air pressure is adjusted into 10 MPas, obtains the fine powder of fineness 3000-3500 order, granularity 5-4.5 μ m;

(2) the gained fine powder is crossed 60 eye mesh screens with whole milk powder, compound sugar, CPP, yolk powder, taurine, sweetener, vitamin and mineral matter mixing more according to the above ratio after 40-50 minute;

(3) screenings is packed with powder packets installation, per minute 35-45 bag, and every bag of 10g, 10 packedly go into 1 box, 80 box-packed production process of going into 1 case.

Beneficial effect is analyzed:

One, the enzymolysis bovine bone powder after the ultramicro grinding

1, the beneficial effect analysis of enzymolysis bovine bone powder

The primary raw material of A, enzymolysis bovine bone powder---ox bone is nutritious, and very high calcareous content is arranged, and can satisfy human body to calcareous daily demand; Its protein exceeds milk powder 23%, is the twice of pork; Contain the synthetic indispensable element of sclerotin such as abundant phosphorus, magnesium, zinc, copper, iron simultaneously.This compound bio is calcareous more to help absorbing and bony remodeling of calcium.

B, enzymolysis bovine bone powder are rich in collagen.Collagen is skin, bone, tendon, the cartilage of human body, the constituent material of blood vessel, and organic 70%-80% is a collagen in the bone, and when bone generated, the collagen fabric that at first must synthesize abundance was formed the framework of bone.

The primary raw material of C, enzymolysis bovine bone powder---ox bone derives from animal, with human body affinity height, and side effects such as edible no gastrointestinal irritation.

D, calcium phosphorus ration suit.Scientific research proves that the imbalance of dietary calcium phosphorus ratio will influence the absorption and the utilization of calcium.Particularly the shortage of phosphorus can cause bone calcium to be lost, and causes that bone calcium reduces.Calcium phosphorus ration is 2: 1 in the enzymolysis bovine bone powder, and ratio is suitable, can promote calcareous storage in vivo to stay, and promotes bone health.

2, the beneficial effect analysis of ultramicro grinding

A, enhancing bioavilability

The enzymolysis bovine bone powder is after ultramicro grinding, and fineness reaches 5-4.5 μ m, enter stomach after, active ingredient can be discharged rapidly, soluble component dissolves under the effect of gastric juice, enters the composition that dissolves behind the small intestine and begins to be absorbed; And these ultra-fine ions are because of the influence of adhesive force, and easily attached on the intestines wall, it is longer to excrete the required time, has improved the absorptivity of its insoluble composition.The fineness that improves material has promptly strengthened its skin effect, bulk effect, quantum effect and macroscopical tunnel-effect etc., is beneficial to by stomach directly to absorb, and has significantly increased absorptivity, significantly increases bioavilability simultaneously.

Enzymolysis bone calcium powder after the ultramicro grinding, the content of the absorptivity of its calcium, the residual rate of calcium, bone mineral content content, bone mineral content density and calcium all is significantly higher than common bone meal, and the absorption of calcium is directly proportional with the skeletal grain size in the bone meal.

B, give the mouthfeel of enzymolysis bovine bone powder exquisiteness

Whether product has fine and smooth lubricious mouthfeel characteristic is caused by multiple factor, but the factor that plays a decisive role is the granularity of enzymolysis bovine bone powder.Test shows, the average grain diameter of enzymolysis bovine bone powder about 25um and wherein most of grain diameter between 15～20um, product has just had fine and smooth lubricious mouthfeel characteristic; When average grain diameter surpassed 40um, product was just obviously felt harsh feeling, the also just obvious variation of aesthetic quality.

Two, the beneficial effect analysis of whole milk powder:

1, whole milk powder is rich in lactose:

Lactose promotes calcareous absorption: lactose can with the calcium chelating, form the low molecular weight soluble complex compound; Lactose can be produced acid by enteron aisle bacterium decomposing and fermenting, and the enteron aisle pH value is reduced, and this two aspect all can promote the absorption of calcium, so lactose can increase the speed that small intestine absorbs calcium.

2, whole milk powder is rich in lactoprotein:

Lactoprotein promotes calcareous absorption: an amount of protein can promote calcium to absorb, because lactoprotein is degraded in intestines and stomach, its catabolite such as lysine, tryptophan, arginine etc. can form soluble calcium salt with calcium, thereby increases the absorption of calcium.

3, whole milk powder is the wholefood that a kind of nutritional labeling is complete, proportion of composing suits, easily digests and assimilates, is of high nutritive value, contain abundant good protein, fat, carbohydrate, be rich in multivitamin and mineral matter, can comprehensively promote children's physique and intelligence development.In addition, the taste that product makes children like is given in the interpolation of whole milk powder more.

Three, the beneficial effect analysis of compound sugar:

1, promote calcareous absorption: compound sugar can promote the fast breeding of Bifidobacterium in the enteron aisle, bifidobacterium fermentation lactose and mineral matters such as calcium in the lactic acid solubilized enteron aisle that produces, magnesium, iron promote the absorption of human body to these mineral matters.Discover that the mechanism that the absorption compound sugar promotes calcium to absorb mainly is by reducing enteron aisle pH value, promote the dissolving of slightly solubility calcium salt and pass through to increase intestinal epithelial cell quantity, enlarging the absorption area of calcium, and then promote the calcareous absorption of human body.

2, compound sugar can promote intestinal beneficial bacterium propagation, suppresses the spoilage organisms growth, regulates functions of intestines and stomach, keeps intestinal health, anti-treating constipation.

Four, the beneficial effect analysis of CPP:

CPP can obviously promote the absorption of calcium: CPP is owing to the compatibility to bivalent metal ion, can form soluble complexes at this weakly alkaline environment of small intestine with calcium, the commutative combination of this moderate strength can prevent the formation of calcium phosphate precipitation effectively and increase the concentration of solubility calcium, do not hinder the exchange with intestinal mucosa again, thereby promote the absorption of calcium in the intestines.Simultaneously, because the CPP molecule has the electric charge of high concentration, make them can resist the further hydrolysis of digestive ferment in the intestines, this character becomes it and guarantees in the prerequisite that enteron aisle plays a role.

Five, the beneficial effect analysis of yolk powder:

1, containing 31% protein in the yolk powder, is the highest complete protein of protein adsorption rate.2, contain 10.5% lecithin in the yolk powder.Lecithin is the important component that constitutes nerve fiber, belongs to the higher nerve nutrient.Can promote brain and neural normal development, ensure neural normal function.Lecithin is the important source that iuntercellular transmits the material-neurotransmitter of information, and sufficient lecithin can improve information transmission speed, improves the brain vigor, be presented as resourceful, learning ability is strong; Simultaneously lecithin is the main resources of cerebral nerve myelin, and the accuracy that sufficient lecithin can raising information transmits is presented as that notice concentrates hypermnesia.Therefore, replenish lecithin memory and the thinking ability that strengthens children had good effect.

Six, the beneficial effect analysis of taurine:

Taurine can obviously promote neural growing and cell proliferation, differentiation, and is dose dependent, plays an important role in the cranial nerve cell growth course.Replenish an amount of taurine and not only can improve learning and memory speed, but also can improve the accuracy of learning and memory, and to neural anti-ageing certain effect that also has.Taurine has good effect to promoting infant, children's brain development, nerve conduction function, simultaneously taurine also have build up health, effect such as relieving fatigue.

Seven, the beneficial effect analysis of vitamin:

1, vitamin D

A, promote the absorption of enteron aisle to calcium, phosphorus

The original point of vitamin D effect is the brush border surface at enterocyte, and calcium is entered in the cell in enteric cavity.In addition 1,25-(OH) 2D3 can with the special receptors bind in the intestinal mucosa cells, promote the synthetic calbindin of intestinal epithelial cell, the calcium ion in the enteric cavity is had stronger affinity, favourable to calcium by the running of intestinal mucosa.Vitamin D also can excite the transport process of enteron aisle to phosphorus, and this transhipment is independently, does not influence each other with the transhipment of calcium.

B, to the mobilization of skeletal calcium

Collaborative with parathyroid gland, vitamin D makes immature osteoclast precursor, changes ripe osteoclast into, promotes bone absorption; Make the bone salts dissolving in the old bone, calcium, phosphorus transporter are in blood, to improve the concentration of blood calcium and serium inorganic phosphorus; Stimulating osteoblast promotes the ripe and bone salts calmness of osteoid tissue on the other hand.

C, promotion kidney heavily absorb calcium, phosphorus

1,25-(OH) 2D3 can promote the heavily absorption of kidney convoluted tubule to calcium, phosphorus, to improve the concentration of blood calcium, serium inorganic phosphorus.

D, osteocyte is presented multiple effect

2, vitamin C

A, promote calcareous absorption: vitamin C is by reducing enteron aisle pH value, the dissolving of promotion slightly solubility calcium salt, thus improve calcareous absorptivity;

B, vitamin C participate in the multiple important biosynthetic process of albumen as the confactor of enzyme, comprise the synthetic of collagen, to form the important matrix of cartilage, sclerotin, enamel and blood vessel epithelium;

C, promotion proline change the reaction of hydrogen proline into, and the hydrogen proline is one of formation collagen important component, so vitamin C can promote the generation of collagen.Thereby it is normal to keep connective tissue;

D, enhancement wound healing and increase are to being injured the esthesis that infects equal pressure.

3, vitamin A

A, vitamin A play an important role to the maturation and the integrality of bone, are the essential compositions that osteocyte is ripe and break up, and participate in bone development and the integrality of keeping epithelial tissue;

B, promotion normal development of skeleton are maintained in the balance between osteocyte and the osteoclast;

C, keep epithelial normal growth and differentiation;

D, promotion are grown: the children growth of the A that is deficient in vitamin is stagnated, hypoevolutism, and skeleton development is bad.

4, vitamin B1

A, vitamin B1 participate in catabolism of carbohydrate with the coenzyme form, play crucial effects for body provides energy;

B, vitamin B1 can promote enterogastric peristalsis, increase appetite, thereby promote upgrowth and development of children;

C, vitamin B1 are kept the normal function of nerve, heart and digestive system;

5, vitamin B2

The metabolism of A, participation carbohydrate, protein, nucleic acid and fat can improve the utilization rate of human body to protein, promotes growth of children;

The growth metabolism of B, participation cell is the necessary nutrient of injected organism tissue metabolism and reparation;

The function of C, protection skin follicle mucous membrane and sebaceous glands.

6, vitamin B6

A, vitamin B6 mainly participate in nearly hundred kinds of enzyme reactions with the form of phosphopyridoxal pyridoxal phosphate.Most relevant with amino acid metabolism;

B, vitamin B6 have good effect to strengthening immunity;

Eight, the beneficial effect analysis of mineral matter:

1, iron

Childhood, occurs ferro element easily and lacks, and reason is as follows: the one, and upgrowth and development of children is fast, and the iron that needs is more, and about per kilogram of body weight needs the iron of 1mg; On the other hand, children are different with the adult, and the available iron of endogenous is less, and its iron that needs more relies on replenishing of food iron, and the absorption that children are particular about food or father and mother do not pay attention to being rich in iron food.The interpolation of iron can improve children's sideropenic situation of dietary intake at ordinary times, and the prevention Iron deficiency anemia in children improves Abwehrkraft des Koepers.

2, zinc

A, aspect zinc and skeleton development, have to studies have shown that much zinc is absolutely necessary in keeping the normal bone metabolism, if zinc deficiency bone translation exception, sclerotin can take place reduces and osteoporosis, replenish and contain zinc preparation, these situations can improve.

Zinc plays a role in bone growth and development by bone alkaline phosphatase (ALP).Bone ALP is typical zinc enzyme, be to contain one of the abundantest enzyme of zinc, and zinc concentrates on the position, activated centre of ALP enzyme, and whether the content of zinc is sufficient among the bone ALP, can directly influence the function of enzyme.Scientific research proves that in the environment of sufficient zinc was arranged, the bone tissue that is growing contained very high ALP level, and skeletal mineralization rate obviously improves simultaneously; In scarce zinc environment, the ALP in the bone tissue not only content can reduce, and activity also obviously reduces, and the growth of bone and the speed of calcification also can obviously slow down, and cause dysostosis.The expression of bone ALP is also relevant with zinc.During zinc deficiency, rna polymerase activity reduces, and causes bone ALP genetic transcription effect to weaken, and makes the synthetic minimizing of bone ALP.

The first step of bone calcification process is a Gegenbaur's cell picked-up ionized calcium, absorbs the phosphate radical of equivalent simultaneously, and both are changed in the organelle (mainly at mitochondria) by a certain percentage, synthetic calcium phosphate under the effect of ALP; Afterwards, calcium phosphate synthetic in the Gegenbaur's cell is secreted born of the same parents, enters bone matrix, with the free phosphoric acid calcium form or be deposited on the hydroxyapatite form in the space of collagenous fiber, and the process of Here it is bone calcification.From the bone calcification process as can be seen, calcium only provides the raw material of bone mineralising, and whether bone can normally carry out calcification then is that function of osteoblast determines.Break up under the situation of normal and calcium source abundance in the Gegenbaur's cell increment, the level of zinc is determining the aggregate velocity of calcium phosphate in the Gegenbaur's cell, and zinc deficiency will make osteoblastic active decline, and then influence the deposition of calcium in bone.

B, zinc can promote the regeneration of upgrowth and development of children and body, and can promote appetite.

3, iodine

Iodine deficiency can cause that children mental retardation, anthropometic are slow.All mammals all must have thyroxine, promptly need iodine to keep the differentiation and the growth of its cell.The growth of puberty children's height, body weight, muscle, bone and sexual development all must have the participation of thyroid hormone, and iodine deficiency can cause upgrowth and development of children and was obstructed in period this, and a main cause of disease of nanism is exactly an iodine deficiency.So add iodine, can promote growth of children comprehensively.

4, magnesium

A, magnesium participate in the formation of bone and tooth.The magnesium of human body 60% is present in the bone tissue;

B, magnesium can activate the effect of various enzymes to the bone metabolism, and participate in regulating the secretion of thyroid hormone, calcitonin and activated vitamin D metabolin.In growing, skeletal growth plays the indirect adjustments and controls effect.Modal bone premature aging, osteoporosis, the soft tissue calciffication of showing as of magnesium deficiency;

The anabolism of C, participation protein.

5, manganese

Gegenbaur's cell and osteoclast are arranged in A, the bone, and the both opposite restriction or checking relation in five elements of both physiological functions is complemented each other again, keeps the metabolism of bone jointly.But when in the body during manganese deficiency, the activity of osteoclast just strengthens, and the activity of Gegenbaur's cell is suppressed, and growth rate slows down, and causes into bone disorders.Original dynamic equilibrium of setting up is in vivo destroyed, and in the course of time, just can make sclerotin become loose, so the quantity not sufficient that contains of manganese also is to lead one of loose factor of matter in the body.Clinical research shows that the content of manganese only is normal person's 1/4 in the patients with osteoporosis body; Manganese participates in the metabolism of plurality of enzymes in the body, and bone neutral and alkali phosphatase is had activation, and the synthetic enzyme system of participating in activation chondroitin sulfate, and the effect that promotes that sclerotin is synthetic is arranged;

B, manganese deficiency are to cause growth retardation, disturb the brain function of bringing into normal play to the harm of children's maximum, make hypophrenia, and the virgin hyperactivity of infant is brought out epilepsy etc.Children's manganese supplement element helps intelligence development, prevents the generation of hyperactivity.

Below by clinical testing data, further specify beneficial effect of the present invention:

1, adopt above-mentioned child form nutritious rich-calcium electuary that 7 years old children of 84 examples are replenished 300mg calcium or placebo, 18 totally months every day.The result shows: 1, every day calcium intake: replenish the calcium the group 800mg about, about placebo 567mg; 2, lumbar vertebra mineral content; The group of replenishing the calcium increases by 20.9% apparently higher than placebo 16.34%; 3, lumbar vertebrae area: the group of replenishing the calcium increases by 11.16% apparently higher than placebo 8.7%; 4, scratch the bone bone density: the group of replenishing the calcium increases by 7.74% and is higher than placebo 6.00%.This result has affirmed that above-mentioned electuary increases significant effective by replenishing the calcium to vertebra and scratching bone bone ore deposit.

2,5 of urine calcium persons that is lower than the normal value among 200 children, and wherein male 3 people (W/H: fat 1 people, H/A: last 1 people), and women 2 people (W/H: 1 people) on the upper side, the calcium deficiency rate is 2.5%.The urine sample pH value is between 5.0-7.0.

Following the tracks of has a clinical manifestation that calcium deficiency such as ring at night, hidrosis are arranged among 5 calcium deficiency children, all the other 4 symptoms are not obvious.Notify the head of a family to adjust diet and oral above-mentioned child form nutritious rich-calcium electuary after detecting calcium deficiency, taking described child form nutritious rich-calcium electuary 400mg every day, 1-2 checks urine calcium after the month, and 4 urine calcium recover normal; 1 has only been carried out the diet adjustment, does not take above-mentioned electuary, and check urine calcium is lower than normally.

In sum, the present invention explores through repetition test, and each composition ratio collocation is scientific and reasonable in the prescription, each nutrition complements each other, and the enzymolysis bovine bone powder ox bone of ultramicro grinding is nutritious, the calcium content height, be rich in collagen, and calcium phosphorus ration is suitable, takes the no GI irritation in back; The enzymolysis ox bone is through after the ultramicro grinding, its fineness reaches 3000-3500 order, granularity 5-4.5 μ m, through after the ultramicro grinding, enzymolysis ox bone particulate specific area enlarges markedly, increase with the enteron aisle contact area, and easily, excrete required time lengthening, can obviously improve the absorptivity of calcium attached on the intestines wall; The whole milk powder, compound sugar, CPP, yolk powder, vitamin and the mineral matter that add, each composition acts synergistically mutually, both can promote calcareous absorption, promoted children's skeleton development, prevent the children calcium deficiency disease, played positive calcium supplementing effect, has the effect that promotes children ' s intelligence development, replenishes the required various nutrients of upgrowth and development of children again, comprehensive promotion upgrowth and development of children; Its production process is pulverized the enzymolysis bovine bone powder, mix through abundant with tuckahoe extracts; wherein be unfavorable for grease and the mucilaginous substance pulverized with abundant absorption; make it go for air-flowing type ultramicro grinding technology; obtain the calcium source fine powder of fineness 3000-3500 order, granularity 5-4.5 μ m; fully mix with other raw material again; used stable process conditions is fit to large-scale industrial production.

Eating effect case of the present invention:

1, Wu * *, the woman, 2 years old, recently often sleeping back hidrosis had a sound just to wake up with a start easily.Detect trace element to hospital, other is normal, and just the calcium value is on the low side, has only 337.Take child form nutritious rich-calcium electuary upon somebody's introduction, every day 10g, after one month, symptom is obviously improved, evening sleep is good especially.After continue again to take.

2, open * *, the man, 4 years old, it was particular about food to have a meal, and height is than child's height of the same age, and health is thin partially, the symptom that has a cramp in the leg occurs through the night of being everlasting.The doctor says that this child grows soon, causes hypocalcia easily.Take child form nutritious rich-calcium electuary, every day, 10g after two months, cannot not have a meal particular about foodly, and the symptom that has a cramp in the leg has also disappeared.After continue again to take.

3, yellow * *, the woman, 7 years old, when washing hair, found a lot of hairs recently to child, also fall when combing one's hair a lot, never this in the past phenomenon.Check trace element to children's hospital, the result shows that the calcium value is on the low side.Through taking child form nutritious rich-calcium electuary, every day 10g, after one month, hair is no longer as having fallen so in the past.After continue again to take.

4, cover * *, the man, 7 years old, mute, can not walk, tooth is short, yellow, soft, and last two major grooves, pigeon breast are separated the no number of times of urine.Send out sample and measure, calcic is 295.4 μ g/g, typical rickets.Take child form nutritious rich-calcium electuary 10g through every day, after three months, snow-white tooth grows, and can run to everywhere play, and it is also normal to separate urine.

5, Wu *, man, 3 years old, just can walk in 2 years old, babble Chu, " O " type leg has become deformity, thigh and shank twist to side, dislocation, the difficulty, unstable of walking, often fall, father and mother worry he grow up the back disability, see the doctor for treatment everywhere, spent more than 4,000 yuan, do not become effective, the doctor says: " by the time five, six years old time have an operation ", the head of a family is very uneasy.A pillow calcium content is after measured: 213.7 μ g/g, for serious calcium deficiency patient, take child form nutritious rich-calcium electuary 10g through every day, and after April, right leg is long straight, and left leg also has a bit crooked, and through taking three months, left leg is also long straight, becomes a normal child of health again.

6, Zhao * *, woman, 30 days, the mature tire newborn baby that cuts open the belly.Body weight 3.7kg gives birth to the back direct rooming-in, feeds because of breast as required.Baby's appetite was medium in 1-10 days, sucked the breast 10 minutes, during 1-1.5 once.Sucking the breast, to embrace a period of time sleeping in the back, puts in bed and promptly cry oneself to wake up, and when having sleeping 1-1.5 in arms, sucking hiccup number of times is more, need eat a little milk or drink water after stop, idol has the milk of overflowing 1.0-20ml, defecate 4-5 time/day, urinates 7-8 time/day.But can lie in bed alone when sleeping the 11-15 days lengths of one's sleep as described above, and sound is difficult for waking up with a start softly.16-20 days, recover 1-10 days situations.30 days clothes child form nutritious rich-calcium electuary 360mg/ days, the length of one's sleep, hiccup reduced during 1.5-2.5, and the back deaeration of sucking the breast embraces slightly that can to put bed sleeping, be difficult for waking up with a start, to full moon, prolong the length of one's sleep, in the time of can reaching 3-4, the hiccup milk that overflows reduces, but and peace and quiet in 10-30 minute play.Height 56cm during full moon, body weight 4.5kg, it is good to grow.

Superiority of the present invention: (1) the present invention adopts the enzymolysis bovine bone powder of ultramicro grinding, and ox bone is nutritious, and the calcium content height is rich in collagen, and calcium phosphorus ration is suitable, takes the no GI irritation in back; Through after the ultramicro grinding, enzymolysis ox bone particulate specific area enlarges markedly, and increases with the enteron aisle contact area, and easily attached on the intestines wall, excretes required time lengthening, makes calcium absorptivity obviously improve than other product of replenishing the calcium; (2) in prescription, add whole milk powder, compound sugar, CPP, yolk powder, vitamin and mineral matter, each composition synergy, both can promote calcareous absorption, promoted children's skeleton development, prevent the children calcium deficiency disease, has the effect that promotes children ' s intelligence development, replenishes the required various nutrients of upgrowth and development of children again, comprehensive promotion upgrowth and development of children; (3) its production process is pulverized the enzymolysis bovine bone powder, mix through abundant with tuckahoe extracts; wherein be unfavorable for grease and the mucilaginous substance pulverized with abundant absorption; make it go for air-flowing type ultramicro grinding technology; obtain the calcium source fine powder of fineness 3000-3500 order, granularity 5-4.5 μ m; fully mix with other raw material again; used stable process conditions is fit to large-scale industrial production.

(4) specific embodiment:

Embodiment 1: a kind of child form nutritious rich-calcium electuary; it is characterized in that comprising enzymolysis bovine bone powder, tuckahoe extracts, whole milk powder, compound sugar, CPP, yolk powder, taurine, sweetener, vitamin C and mineral matter zinc, its weight quota is than being enzymolysis bovine bone powder 20: tuckahoe extracts 2: whole milk powder 55: compound sugar 13: CPP 6: yolk powder 2: taurine 0.1: sweetener 0.5: vitamin C 0.7: mineral matter zinc 0.9.

The production process of above-mentioned child form nutritious rich-calcium electuary is characterized in that may further comprise the steps:

(1) uses Universalpulverizer that tuckahoe extracts is ground into fine powder, cross 100 eye mesh screens; Tuckahoe extracts fine powder, enzymolysis bovine bone powder are put in the trough type mixing machine, mixed 30 minutes; Use Universalpulverizer to pulverize once in this mixture, wherein be unfavorable for grease and the mucilaginous substance pulverized not making it to adhere to micronizer inwall and pipeline with abundant absorption; Place micronizer to pulverize in the mixture after the above-mentioned pulverizing, compressed air pressure is adjusted into 10 MPas, obtains the fine powder of fineness 3500 orders, granularity 4.5 μ m;

(2) the gained fine powder mixes mistake 60 eye mesh screens after 50 minutes more according to the above ratio with whole milk powder, compound sugar, CPP, yolk powder, taurine, sweetener, vitamin V C and mineral matter zinc;

(3) screenings is packed with powder packets installation, 35 bags of per minutes, and every bag of 10g, 10 packedly go into 1 box, 80 box-packed production process of going into 1 case.

Embodiment 2: a kind of child form nutritious rich-calcium electuary; it is characterized in that comprising enzymolysis bovine bone powder, tuckahoe extracts, whole milk powder, compound sugar, CPP, yolk powder, taurine, sweetener, vitamin D and mineral matter iodine, its weight quota is than being enzymolysis bovine bone powder 18: tuckahoe extracts 2: whole milk powder 50: compound sugar 20: CPP 4: yolk powder 4: taurine 0.2: sweetener 0.3: vitamin D 0.9: mineral matter iodine 0.7.

The production process of above-mentioned child form nutritious rich-calcium electuary is characterized in that may further comprise the steps:

(1) uses Universalpulverizer that tuckahoe extracts is ground into fine powder, cross 60 eye mesh screens; Tuckahoe extracts fine powder, enzymolysis bovine bone powder are put in the trough type mixing machine, mixed 20 minutes; Use Universalpulverizer to pulverize once in this mixture, wherein be unfavorable for grease and the mucilaginous substance pulverized not making it to adhere to micronizer inwall and pipeline with abundant absorption; Place micronizer to pulverize in the mixture after the above-mentioned pulverizing, compressed air pressure is adjusted into 10 MPas, obtains the fine powder of fineness 3000 orders, granularity 5 μ m;

(2) the gained fine powder mixes mistake 60 eye mesh screens after 40 minutes more according to the above ratio with whole milk powder, compound sugar, CPP, yolk powder, taurine, sweetener, vitamin V D and mineral matter iodine;

(3) screenings is packed with powder packets installation, 45 bags of per minutes, and every bag of 10g, 10 packedly go into 1 box, 80 box-packed production process of going into 1 case.

Embodiment 3: a kind of child form nutritious rich-calcium electuary; it is characterized in that comprising enzymolysis bovine bone powder, tuckahoe extracts, whole milk powder, compound sugar, CPP, yolk powder, taurine, sweetener, vitamin C, vitamin D, mineral matter zinc, mineral matter iodine, its weight quota is than being enzymolysis bovine bone powder 20: tuckahoe extracts 2.5: whole milk powder 53: compound sugar 15: CPP 5: yolk powder 3: taurine 0.15: sweetener 0.4: vitamin C 0.5: vitamin D 0.3: mineral matter zinc 0.6: mineral matter iodine 0.2.

The production process of above-mentioned child form nutritious rich-calcium electuary is characterized in that may further comprise the steps:

(1) uses Universalpulverizer that tuckahoe extracts is ground into fine powder, cross 80 eye mesh screens; Tuckahoe extracts fine powder, enzymolysis bovine bone powder are put in the trough type mixing machine, mixed 25 minutes; Use Universalpulverizer to pulverize once in this mixture, wherein be unfavorable for grease and the mucilaginous substance pulverized not making it to adhere to micronizer inwall and pipeline with abundant absorption; Place micronizer to pulverize in the mixture after the above-mentioned pulverizing, compressed air pressure is adjusted into 10 MPas, obtains the fine powder of fineness 3300 orders, granularity 4.8 μ m;

(2) the gained fine powder mixes mistake 60 eye mesh screens after 45 minutes more according to the above ratio with whole milk powder, compound sugar, CPP, yolk powder, taurine, sweetener, vitamin C, vitamin D, mineral matter zinc and mineral matter iodine;

(3) screenings is packed with powder packets installation, 40 bags of per minutes, and every bag of 10g, 10 packedly go into 1 box, 80 box-packed production process of going into 1 case.

Embodiment 4: a kind of child form nutritious rich-calcium electuary; it is characterized in that comprising the enzymolysis bovine bone powder; tuckahoe extracts; whole milk powder; compound sugar; CPP; yolk powder; taurine; sweetener; vitamin V A; VB1; VB2; VB6; VC; VD and mineral matter zinc; iron; iodine; manganese; magnesium, its weight quota is than being enzymolysis bovine bone powder 19: tuckahoe extracts 3: whole milk powder 52: compound sugar 15: CPP 5: yolk powder 4: taurine 0.15: sweetener 0.4: vitamin V A 0.1: VB1 0.1: VB2 0.1: VB6 0.1: VC 0.2: VD 0.2: mineral matter zinc 0.2: iron 0.1: iodine 0.2: manganese 0.1: magnesium 0.1.

The production process of above-mentioned child form nutritious rich-calcium electuary is characterized in that may further comprise the steps:

(1) uses Universalpulverizer that tuckahoe extracts is ground into fine powder, cross 80 eye mesh screens; Tuckahoe extracts fine powder, enzymolysis bovine bone powder are put in the trough type mixing machine, mixed 25 minutes; Use Universalpulverizer to pulverize once in this mixture, wherein be unfavorable for grease and the mucilaginous substance pulverized not making it to adhere to micronizer inwall and pipeline with abundant absorption; Place micronizer to pulverize in the mixture after the above-mentioned pulverizing, compressed air pressure is adjusted into 10 MPas, obtains the fine powder of fineness 3300 orders, granularity 4.8 μ m;

(2) the gained fine powder mixes mistake 60 eye mesh screens after 45 minutes more according to the above ratio with whole milk powder, compound sugar, CPP, yolk powder, taurine, sweetener, vitamin V A, VB1, VB2, VB6, VC, VD and mineral matter zinc, iron, iodine, manganese, magnesium;

(3) screenings is packed with powder packets installation, 30 bags of per minutes, and every bag of 10g, 10 packedly go into 1 box, 80 box-packed production process of going into 1 case.

Claims (10)

1, a kind of child form nutritious rich-calcium electuary; it is characterized in that comprising enzymolysis bovine bone powder, tuckahoe extracts, whole milk powder, compound sugar, CPP, yolk powder, taurine, sweetener, vitamin and mineral matter, its weight quota is than being enzymolysis bovine bone powder 18～21: tuckahoe extracts 2.0-3.0: whole milk powder 50～55: compound sugar 10～20: CPP 4～6: yolk powder 2～4: taurine 0.1-0.2: sweetener 0.3～0.5: vitamin 0.7～0.9: mineral matter 0.7～0.9.

2, child form nutritious rich-calcium electuary according to claim 1 is characterized in that vitamin comprises a kind of or its combination among VA, VB1, VB2, VB6, VC, the VD.

3, child form nutritious rich-calcium electuary according to claim 1 and 2 is characterized in that vitamin comprises a kind of or its combination among VC and the VD.

4, child form nutritious rich-calcium electuary according to claim 1 is characterized in that mineral matter comprises a kind of or its combination in zinc, iron, iodine, manganese, the magnesium.

5,, it is characterized in that mineral matter comprises a kind of or its combination in zinc and the iodine according to claim 1 or 4 described child form nutritious rich-calcium electuaries.

6, child form nutritious rich-calcium electuary according to claim 1; it is characterized in that comprising enzymolysis bovine bone powder, tuckahoe extracts, whole milk powder, compound sugar, CPP, yolk powder, taurine, sweetener, vitamin C and mineral matter zinc, its weight quota is than being enzymolysis bovine bone powder 20: tuckahoe extracts 2: whole milk powder 55: compound sugar 13: CPP 6: yolk powder 2: taurine 0.1: sweetener 0.5: vitamin C 0.7: mineral matter zinc 0.9.

7, child form nutritious rich-calcium electuary according to claim 1; it is characterized in that comprising enzymolysis bovine bone powder, tuckahoe extracts, whole milk powder, compound sugar, CPP, yolk powder, taurine, sweetener, vitamin D and mineral matter iodine, its weight quota is than being enzymolysis bovine bone powder 18: tuckahoe extracts 2: whole milk powder 50: compound sugar 20: CPP 4: yolk powder 4: taurine 0.2: sweetener 0.3: vitamin D 0.9: mineral matter iodine 0.7.

8, child form nutritious rich-calcium electuary according to claim 1; it is characterized in that comprising enzymolysis bovine bone powder, tuckahoe extracts, whole milk powder, compound sugar, CPP, yolk powder, taurine, sweetener, vitamin C, vitamin D, mineral matter zinc, mineral matter iodine, its weight quota is than being enzymolysis bovine bone powder 20: tuckahoe extracts 2.5: whole milk powder 53: compound sugar 15: CPP 5: yolk powder 3: taurine 0.15: sweetener 0.4: vitamin C 0.5: vitamin D 0.3: mineral matter zinc 0.6: mineral matter iodine 0.2.

9; child form nutritious rich-calcium electuary according to claim 1; it is characterized in that comprising the enzymolysis bovine bone powder; tuckahoe extracts; whole milk powder; compound sugar; CPP; yolk powder; taurine; sweetener; vitamin V A; VB1; VB2; VB6; VC; VD and mineral matter zinc; iron; iodine; manganese; magnesium, its weight quota is than being enzymolysis bovine bone powder 19: tuckahoe extracts 3: whole milk powder 52: compound sugar 15: CPP 5: yolk powder 4: taurine 0.15: sweetener 0.4: vitamin V A 0.1: VB1 0.1: VB2 0.1: VB6 0.1: VC 0.2: VD 0.2: mineral matter zinc 0.2: iron 0.1: iodine 0.2: manganese 0.1: magnesium 0.1.

10, a kind of production process of above-mentioned child form nutritious rich-calcium electuary is characterized in that may further comprise the steps:

(1) uses Universalpulverizer that tuckahoe extracts is ground into fine powder, cross the 60-100 eye mesh screen; Tuckahoe extracts fine powder, enzymolysis bovine bone powder are put in the trough type mixing machine, mixed 20-30 minute; Use Universalpulverizer to pulverize once in this mixture, wherein be unfavorable for grease and the mucilaginous substance pulverized not making it to adhere to micronizer inwall and pipeline with abundant absorption; Place micronizer to pulverize in the mixture after the above-mentioned pulverizing, compressed air pressure is adjusted into 10 MPas, obtains the fine powder of fineness 3000-3500 order, granularity 5-4.5 μ m;

(2) the gained fine powder is crossed 60 eye mesh screens with whole milk powder, compound sugar, CPP, yolk powder, taurine, sweetener, vitamin and mineral matter mixing more according to the above ratio after 40-50 minute;

(3) screenings is packed with powder packets installation, per minute 35-45 bag, and every bag of 10g, 10 packedly go into 1 box, 80 box-packed production process of going into 1 case.