CN101129406A - Formula of compound colla carapaeis corii asini series products and method for producing the same - Google Patents
Formula of compound colla carapaeis corii asini series products and method for producing the same Download PDFInfo
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Abstract
The invention discloses a formulation and making method of serial product of donkey-hide gelatin, which comprises the following steps: adopting donkey-hide gelatin, isomaltose oligosaccharide-900, calcium carbonate, oligosaccharide, vitamin A, vitamin B12, vitamin C, vitamin D3, folic acid, chlorhematin and zinc citrate as raw material; forming the formulation of donkey-hide gelatin dismutation iron-vane or capsule, donkey-hide gelatin dismutation-D calcium tablet or capsule, donkey-hide gelatin ferro-calcium zinc tablet or capsule, donkey-hide gelatin irony folic acid vitamin B12 tablet or capsule (1); grinding; extracting; manufacturing; obtaining the tablet or capsule.
Description
Technical field
The present invention relates to the prescription and the manufacture method of compound colla carapaeis corii asini series products, the invention belongs to food, medicine and manufacture field.
Background technology
The present invention use national regulation medicine-food two-purpose and food enrichment, food additive be raw material, according to its biological activity, science is formed compound colla carapaeis corii asini series products.Compound colla carapaeis corii asini series products has nourishing YIN and supplementing blood, invigorating the spleen and regulating the stomach respectively, vitimin supplement A, B12, C, D, folic acid, and the effect of additional calcium, ferrum, zinc supplement, effect is remarkable.
Summary of the invention:
1. the prescription of compound colla carapaeis corii asini series products and manufacture method are with Colla Corii Asini, dextrinosan-900, calcium carbonate, ferrous lactate, vitamin A, vitamin B
12, vitamin C, vitamin D
3, folic acid, chlorhematin, zinc citrate is material composition, according to different physiologically actives, science is formed the prescription of compound colla carapaeis corii asini series products, through pulverize, extract, processing, make tablet or capsule.
2. Colla Corii Asini qi iron plate or capsule formula (1) is characterized in that by its prescription preparation percentage by weight being: Colla Corii Asini 60～90%, ferrous lactate 0.8～1.6%, vitamin C 0.40～0.80%, vitamin A 0.012～0.024%, dextrinosan-900 15～30%.Colla Corii Asini qi iron plate or capsule formula (1) preparation method is characterized in that, gets Colla Corii Asini, ferrous lactate, vitamin C, dextrinosan-900 pulverize separately and becomes fine powder, sieves, and adds right amount of auxiliary materials, mixes, and granulates drying, tabletting, coating; Or divide encapsulated.
3. Colla Corii Asini qi iron plate or capsule formula (2) is characterized in that by its prescription preparation percentage by weight being: Colla Corii Asini 60～90%, chlorhematin 1.5～3.0%, vitamin C 0.40～0.80%, vitamin A 0.012～0.024%, dextrinosan-900 15～30%.Colla Corii Asini qi iron plate or capsule formula (2) preparation method is characterized in that, gets Colla Corii Asini, chlorhematin, vitamin C, vitamin A, dextrinosan-900 pulverize separately and becomes fine powder, sieves, and adds right amount of auxiliary materials, mixes, and granulates drying, tabletting, coating; Or divide encapsulated.
4. Colla Corii Asini fork D calcium iron plate or capsule formula (1), it is characterized in that being: Colla Corii Asini 30～50%, calcium carbonate 20～40%, ferrous lactate 0.8～1.4%, vitamin A 0.01～0.02%, vitamin C 0.5～1%, vitamin D3 0.00003～0.00006%, dextrinosan-900 10～20% by its formulated percentage by weight.Colla Corii Asini fork D calcium iron plate or capsule (1) preparation method is characterized in that, get Colla Corii Asini, calcium carbonate, ferrous lactate, vitamin A, vitamin C, vitamin D
3, dextrinosan-900 pulverize separately becomes fine powder, sieves, and adds right amount of auxiliary materials, mixes, and granulates drying, tabletting, coating; Or divide encapsulated.
5. Colla Corii Asini fork D calcium iron plate or capsule formula (2), it is characterized in that being by its prescription preparation percentage by weight: Colla Corii Asini 30～50%, calcium carbonate 20～40%, chlorhematin 2～4%, vitamin A 0.01～0.02%, vitamin C 0.5～1%,, vitamin D
30.00004 dextrinosan-900 10～20%～0.00008%.Colla Corii Asini fork D calcium iron plate or capsule formula (2) preparation method is characterized in that, get Colla Corii Asini, calcium carbonate, chlorhematin, vitamin A, vitamin C, vitamin D
3, dextrinosan-900 pulverize separately becomes fine powder, sieves, and adds right amount of auxiliary materials, mixes, and granulates drying, tabletting, coating; Or divide encapsulated.
6. Colla Corii Asini calcium ferrum zinc metal sheet or capsule formula (1), it is characterized in that being: Colla Corii Asini 30～60%, calcium carbonate 15～30%, ferrous lactate 1.4～2.5%, vitamin D3 0.00005～0.0001%, vitamin C 0.7～1.4%, zinc citrate 0.7～1.4%, dextrinosan-900 15～30% by its prescription preparation percentage by weight.Colla Corii Asini calcium ferrum zinc metal sheet or capsule formula (1) preparation method is characterized in that: get Colla Corii Asini, calcium carbonate, ferrous lactate, vitamin D
3, vitamin C, zinc citrate pulverize separately become fine powder, sieves, and adds right amount of auxiliary materials, mixes, and granulates drying, tabletting, coating; Or divide encapsulated.
7. the prescription of Colla Corii Asini calcium ferrum zinc metal sheet or capsule formula (2) is characterized in that, by its prescription preparation percentage by weight is: Colla Corii Asini 30～60%, calcium carbonate 20～40%, chlorhematin 3～6%, vitamin D
30.00005 vitamin C C 0.7～1.4%～0.0001%,, zinc citrate 0.7～1.4%, dextrinosan-900 15～30%, Colla Corii Asini calcium ferrum zinc metal sheet or capsule formula (2) preparation method, it is characterized in that: Colla Corii Asini calcium ferrum zinc metal sheet preparation method is characterized in that: get Colla Corii Asini, calcium carbonate, chlorhematin, vitamin D
3, vitamin C, zinc citrate pulverize separately become fine powder, sieves, and adds right amount of auxiliary materials, mixes, and granulates drying, tabletting, coating; Or divide encapsulated.
8. Colla Corii Asini iron folic acid vitamin B
12Sheet or capsule formula (1) is characterized in that, by its prescription preparation percentage by weight are: Colla Corii Asini 33～66%, folic acid 0.0044～0.0088%, vitamin B
120.00018～0.00036%, ferrous lactate 1.5～2.6%, vitamin C 1.5～3.0%, dextrinosan-900 25～50%.Colla Corii Asini iron folic acid vitamin B
12Sheet or capsule formula (1) preparation method is characterized in that: get Colla Corii Asini, folic acid, vitamin B
12, ferrous lactate, vitamin C, dextrinosan-900 pulverize separately become fine powder, sieves, and adds right amount of auxiliary materials, mixes, and granulates drying, tabletting, coating; Or divide encapsulated.
9. Colla Corii Asini iron folic acid vitamin B
12Sheet or capsule formula (2) is characterized in that, by its prescription preparation percentage by weight are: Colla Corii Asini 33～66%, folic acid 0.0044～0.0088%, vitamin B
120.00016～0.0003%, chlorhematin 3.5～7%, vitamin C 1.6～3.2%, dextrinosan-900 25～50%.Colla Corii Asini iron folic acid vitamin B
12Sheet or capsule formula (2) preparation method is characterized in that, gets Colla Corii Asini, folic acid, vitamin B
12, chlorhematin, vitamin A, vitamin C, dextrinosan-900 pulverize separately become fine powder, sieves, and adds right amount of auxiliary materials, mixes, and granulates drying, tabletting, coating; Or divide encapsulated.
Attached:
Adnexa 1. embodiment 1: the pharmacological research of compound colla carapaeis corii asini series products
Adnexa 2. embodiment 2: the clinical efficacy research of compound colla carapaeis corii asini series products
Adnexa 1. embodiment 1: the pharmacological research of compound colla carapaeis corii asini series products
The pharmacological research of compound colla carapaeis corii asini series products
The prescription of Colla Corii Asini series of products and manufacture method are with Colla Corii Asini, dextrinosan-900, calcium carbonate, ferrous lactate, vitamin A, vitamin B12, vitamin C, vitamin D
3, folic acid, chlorhematin, zinc citrate forms different formulations.
Its pharmacological research is as follows:
(1), Colla Corii Asini, after the skin unhairing for equine species donkey Equus asinus L., boil the black blob of viscose that forms.
The sweet flat matter profit of Colla Corii Asini nature and flavor, the sticking convergence of property, effect is nourishing YIN and supplementing blood, and is antiabortive.Cure mainly blood deficiency, cough due to consumptive disease, is had blood in stool menoxenia, metrorrhagia, vaginal bleeding during pregnancy at haematemesis, epistaxis.
Chemical constituent
Colla Corii Asini is a class glutin, hydrolysis can produce several amino acids, mainly contains: glycine (Glycine), proline (Prolire), glutamic acid (Glutamicacid), alanine (Alanine), arginine (Arginine), aspartic acid (Aspqrticacid), lysine (Lysine), phenylalanine (Phenylanine), serine (Serine), histidine (Histidine), cysteine (Cysteine), valine (Valine), methionine (Methionine), isoleucine (Isoleucine), leucine (Leucine), tyrosine (Tyrosine), tryptophan (Tryptophan), hydroxyproline (Hydroxyproline), threonine (Threocine) etc.And 20 kinds of elements are arranged: potassium, sodium, calcium, magnesium, ferrum, copper, chromium, manganese, zinc, stannum, lead, silver, nickel, molybdenum, strontium, barium, titanium, zirconium, platinum, inscription.
The Colla Corii Asini pharmacological action
1. promote the hemopoietic function Colla Corii Asini to have the RBC number of raising and hemoglobin, promote the effect of hemopoietic function.After a large amount of blood drawings cause the dog hemorrhagic anemia, irritated stomach 10 with Colla Corii Asini solution, every day, 30g can accelerate the speed that erythrocyte and hemoglobin increase.The rabbit of hemorrhagic anemia also there is the effect of rising hemoglobin, erythrocyte and leukocyte count.Mice is only irritated stomach 20% glue 0.5ml/ every day, continuous 11 days, also can obviously increase content of hemoglobin.Colla Corii Asini nourishing blood mechanism may contain aminoacid with it, be rich in ferrum and trace element, to contain higher factors such as animal proteinum relevant.
2. anastalsis experimental results show that: oral Colla Corii Asini can promote the coagulation process of rabbit very significantly, and clotting time is shortened.Slide method: shortened to 2.0 minutes by 4.5 minutes; Test tube method: shortened to 3.0 minutes by 5.5 minutes.Its hemostatic mechanism may be by improve platelet content in the blood stop because of thrombocytopenia cause hemorrhage, also have and think because of Colla Corii Asini contains collagen protein, the tool viscosity, when the postadhesion that is absorbed by the body on the blood capillary surface, shorten the setting time of blood, played anastalsis.This effect only is used for internal hemorrhages such as haematemesis, epistaxis, to outside massive hemorrhage DeGrain.
3. to behind the Immune Effects mouse stomach Colla Corii Asini solution, can obviously improve the phagocytic activity of peritoneal macrophage.Mouse stomach Colla Corii Asini solution 2.5g/kg and 5.0g/kg, the immunologic opsonin rosette forming cell of spleen and specificity Flos Rosae Rugosae rate obviously increase.Charcoal is cleaned up experiment and is shown that Colla Corii Asini has facilitation to Mouse Liver, spleen mononuclear phagocyte.Mice is obeyed Colla Corii Asini after 7 days continuously, and natural killer cell activity is significantly strengthened.Colla Corii Asini has the healthy human lymphocyte transformation of promotion.
4. anoxia enduring, cold resistant, the oral Colla Corii Asini experiment of antifatigue effect mice show that Colla Corii Asini can significantly improve the mice hypoxia-bearing capability, obviously strengthen the cold resistant effect of animal, strengthen the antifatigue effect of mice in the swimming test very significantly.
5. behind the Antiradiation injury effect donkey-hide gelatin oral Antiradiation injury effect is arranged.The pre-irradiation administration can improve the survival rate of 60Co irradiation administration 800Rd mice in 3 days or 7 days, and administration was renderd a service strong on 7th behind the pre-irradiation than 3 days protection of pre-irradiation administration.To accepting the mice of 1 irradiation of 60Co700Rd, Colla Corii Asini solution was irritated stomach after 9 days, and hemoglobin, hematocrit obviously rise.After irritating stomach Colla Corii Asini 1.56g/kg every day, can make through 60Co irradiation mice blood hemoglobin, leukocyte count and bone marrow nucleated cell number and obviously increase.
6. to calcium metabolism to influence in the Colla Corii Asini calcium content higher, can increase the intake of calcium in the body after taking, improve effectively that the bone calcium that causes because of calcium deficiency is lost, calcium salt outflow, osteoporosis and hyperosteogeny and all kinds of fracture.Animal (dog) evidence Colla Corii Asini has the balanced action of improvement calcium.Irritate stomach with Colla Corii Asini, simultaneously in food, add calcium carbonate, can increase the absorption of calcium and retention in vivo, blood calcium is slightly increased, the effect of the helpful calcareous transhipment of glycine that this may be in the Colla Corii Asini to be contained.The clinical treatment tetany of using it for.
7. anti-flesh flaccidity effect Colla Corii Asini has this disease of prevention that the effect of symptom takes place and improves to cause into the Cavia porcellus of progressive muscular dystrophy disease with special forage feed.This effect may be relevant with contained calcium, phosphorus, manganese and glycine in the Colla Corii Asini.
8. Antishock function is given hemorrhagic shock or histamine shock's cat vein input with 5% refining Colla Corii Asini solution, can make the very fast recovery of blood pressure.Donkey-hide gelatin oral gives the enterogenous endotoxin shock model that Bacterium prodigiosum is duplicated, the blood pressure drops that endotoxin is caused, and total peripheral resistance raises, and blood viscosity rises and the bulbar Conjunctiva Microcirculation obstacle alleviates or recover normal as early as possible.Colla Corii Asini has anti-vascular leakage effect, and this may be one of mechanism of its Antishock function.Experimental results show that Colla Corii Asini can make the blood plasma of scalding the rabbit ear ooze out minimizing, and alleviate the lung blood vessel exudative process that causes behind the intravenous injection oleic acid; Experimental results show that again that Colla Corii Asini can make injects behind the endotoxin viscosity of blood and increases degree and descend to some extent, this illustrates that all Colla Corii Asini has the effect that the rational vascular permeability of enantiopathy increases, this effect can reduce blood plasma and ooze out, kept effective circulating load to a certain extent, help microcirculatory blood perfusion and recover normal, the hematodinamics situation is improved.
9. inducing diuresis to remove edema effect Colla Corii Asini is that the vivo acid storehouse is increased to the therapeutical effect of nephritis, and plasma proteins improves thereupon, and colloid osmotic pressure raises in the blood, helps the diuresis detumescent.But the albuminuretic direct effect of not disappearing, the improvement of nephridial tissue pathology is not obvious.Owing to improve nutrition of whole body, stimulating appetite decomposes aminoacid and reduces, and also helps the improvement of kidney disease.It is main that Colla Corii Asini contains non essential amino acid, so to renal insufficiency Ying Shenyong, otherwise be unfavorable for the decline of creatinine, blood urea nitrogen.
10. antitumaous effect: Colla Corii Asini is the paramedicines of radiotherapy, patients undergoing chemotherapy.Having experiment to adopt the Donga Colla Corii Asini is raw material, observes its influence to specific immune function, finds that the immunity of Colla Corii Asini pair cell has dual regulation.And the NK cell activity had potentiation preferably, and the NK cell plays a role in the generation of preventing tumor.In addition, Colla Corii Asini has the healthy human lymphocyte transformation of promotion, also can improve the lymhocyte transformation rate of tumor patient simultaneously, in order to the treatment tumor, tumor is slowed down, doing well,improving, and the life-span prolongs.
(2) dextrinosan-900 dextrinosan-900, claim again " high-purity bifidus factor ", be to be raw material with refining corn starch, develop the novel sugared source that forms by introducing foreign biomolecule enzyme engineering technology and advanced technologies, oligosaccharide extensively is used in the different food manufacturings abroad, all has bright development prospect and exploitation value from its practicality and functional aspect.
Colourless or the little yellow of dextrinosan-900, free from extraneous odour, have low sugariness, low heat value, moisture retention, dental caries, bacillus bifidus in the human body intestinal canal there is splendid cultivation effect, non-fermentable carbohydrate content is greater than 90%, glucose content %＜4.0, substantially do not contain the glucose composition, therefore be particularly suitable for diabetes patient.
The physiological function of dextrinosan-900
1. impel bacillus bifidus propagation
The bacillus bifidus totally nontoxic, no matter healthy people or patient, bacillus bifidus quantity is The more the better in the intestinal.Human trial shows, takes in oligosaccharide and can impel bacillus bifidus propagation, thereby suppressed noxious bacteria, as the growth of bacillus aerogenes capsulatus.Take in the 2-10g oligosaccharide every day after lasting several weeks, the bifidobacteria viable bacteria number in the intestinal on average increases by 7.5 times.And the bacillus aerogenes capsulatus sum has reduced 81%; Also increase 1-2 doubly for the oligosaccharide of some kind lactein quantity that is produced of turning sour, it (mainly is acetic acid and lactic acid that the clostridial quantity of generation gas pod membrane then reduces by 0.5-0.06 times of bifidobacterium fermentation oligosaccharide generation short-chain fatty acid, mol ratio is 3: 2) and some antibiotics materials, thus can suppress the growth and breeding of external source pathogenic bacterium and the intrinsic Putrefying bacteria of enteral.Acetic acid and lactic acid all can suppress the noxious bacteria in the intestinal.The bacillus bifidus element is a kind of antibiotics material that is produced by bifidobacterium bifidum, and it can suppress shigella, Salmonella, staphylococcus aureus, escherichia coli and some other microorganism very effectively.A kind of high molecular weight material that is produced by bifidobacteria infantis also can effectively suppress shigella, Salmonella, escherichia coli etc.
2. reduce the generation of poisonous tunning and noxious bacteria enzyme
Show with the outer feces culture experiment of active body in the human body body, take in the generation that oligosaccharide can reduce poisonous tunning and noxious bacteria prunus mume (sieb.) sieb.et zucc. effectively.Take in the 3-6g oligosaccharide every day, or add the oligosaccharide of respective numbers in the external sodium azide, can reduce the generation of 44.6% poisonous tunning and 40.9% noxious bacteria enzyme within 3 weeks.
3. suppress pathogen and diarrhoea
Take in oligosaccharide or bacillus bifidus and all can suppress pathogen and diarrhoea, both mechanism of action is the same, all is to have reduced the intestinal toxic number of bacteria.
4. prevent constipation
The bifidobacterium fermentation oligosaccharide produces a large amount of short-chain fatty acid, can stimulate intestinal peristalsis promoting, increases the feces wettability and keep certain osmotic pressure, thereby prevent the generation of constipation.In human trial, take in the 3.0-10.0g oligosaccharide every day, just can play the effect that prevents constipation within the week.
5. the liver protecting function
Take in the formation that oligosaccharide or bacillus bifidus can reduce the toxic metabolite product, this has alleviated the burden that liver divides toxolysin greatly.
6. reduce serum cholesterol
A large amount of human trials can reduce serum cholesterol level after having confirmed to take in oligosaccharide.Take in the 6-12g oligosaccharide every day and continue 2 thoughtful 3 months, the total serum cholesterol can reduce 20-50dl.The lactobacillus and the fermented dairy product thereof that comprise bacillus bifidus all can reduce the total serum cholesterol levels, improve the ratio that women's serum middle-high density lipoprotein cholesterol accounts for T-CHOL.
The reduction of serum cholesterol level is considered to because the result that the microorganism species balance changes in the intestinal.And in vitro tests shows that the inherent bacillus acidophilus of 12 strains can absorb cholesterol in the human body intestinal canal, and bacillus acidophilus 2056 strain bacterium can suppress the absorption of small bowel to the cholesterol micella.The bacillus bifidus metabolism produces the ability of nicotinic acid and the reduction of serum cholesterol level also has certain relation.Someone thinks that bacillus bifidus is by suppressing activated T antibacterial in the human body, and the new low density lipoprotein, LDL accepter that forms of control plays the effect that reduces serum cholesterol content.Result of the test to mice shows that bacillus bifidus is controlled the synthetic of cholesterol and the content of reduction serum cholesterol by influencing the activity of beta-hydroxy-β methylglutaric acid list acyl fear enzyme A reductase.
7. bring high blood pressure down
Take in the effect that oligosaccharide brings high blood pressure down in addition, related example is as follows:
1 46 hyperlipemic patients of example are taken in the 11.5g oligosaccharide after lasting 5 weeks every day, and its diastole flattens the 799.8Pa (6mmHg) that all descended, and blood glucose value on an empty stomach also descends to some extent, but not clearly.
Example 2, allow 6 28-48 year healthy adult male take in the 3.0g oligosaccharide a continuous every day in week, its diastole flattens and has all reduced 839.7pa (6.3mmHg).Studies show that the ratio that the bacillus bifidus number accounts for total bacteria count in the height that a people's diastole is pressed and its feces is tangible negative relation.
8. enhancing human body immunity power is anticancer
A large amount of animal test results show that bacillus bifidus a large amount of breedings in intestinal can play antitumaous effect.This antitumaous effect is given the credit to cell, cell wall constituent and the exocytosis thing of bacillus bifidus, and the immunity of body is improved.For example, feed the monofactorial germfree mouse of bifidobacterium longum, live longly than untreated germfree mouse.Oral or intravenous injection has the dust Xi Shi escherichia coli or the intravenous injection creotoxin of lethal effect, is having under the simultaneous situation of active Bifidobacterium, and mice in week, just can be induced anti-lethal effect at 2-3.But in athymic germfree mouse, do not find this phenomenon.This shows that bacillus bifidus can be induced the bacterial immune of anti-dust Xi Shi coli-infection.
Oral bacillus bifidus goods were fed with the colibacillary germfree mouse of pathogen dust Xi Shi after 2 days, did not have what symptom clinically, but fed with dust Xi Shi escherichia coli before oral bacillus bifidus, just occurred the phenomena of mortality within 48 hours.The bacillus bifidus single factor experiment of germfree mouse has also confirmed the facilitation of bacillus bifidus to immunity.
9. generate nutrient substance
Bacillus bifidus is the natural synthetic vitamin B1 of energy, vitamin B2, vitamin B6, vitamin B12, nicotinic acid and folic acid in intestinal, but can not synthetic vitamin K.In the bifidobacterium fermentation milk product lactose part transform lactic acid, solved people's lactose problem of resistance, also increased simultaneously the content of water solublity acceptable calcium, make that milk product is easier to be digested and assimilated.
10. low-yield or noenergy
Functional oligose is difficult to or is not absorbed by human consumption, the energy value that is provided is very low or do not have at all, so can in low-energy food, play a role, satisfy those to greatest extent and liked sweets and the worry person's of getting fat requirement, also can supply diabetes patient, adiposis patient and hypoglycemia patient edible.
Can not cause that the tooth dental caries become, dental caries since oral microorganism particularly streptococcus mutans corrode and cause that therefore functional oligose can not cause the change of tooth dental caries because be not the suitable effect substrate of these oral microorganisms.
(3) calcium carbonate
Calcium is a kind of essential element, also is the abundantest magnanimity metallic element of content in the human body, and content is only second to C, H, O, N.Total calcium can reach 1000～1200g in the normal adult body, accounts for about 2% of human body body weight.Wherein the calcium more than 99% is present in skeleton, the tooth, the calcium of remaining less than 1% is distributed in body fluid and other tissue.
Calcium is skeleton and the most basic constituent of tooth.Calcium in the bone is mainly with phosphate, secondly with carbonate, citrate.Usually the concentration of calcium is 9～11mg/100ml (no age, sex difference) in the blood plasma.
Calcium plays an important role in various physiology of body and biochemical process.Except that bone calcium, especially miscible pond calcium is that to keep all cells normal physiological state necessary.It can reduce the permeability of blood capillary and cell membrane, prevents to ooze out, and controls inflammation and edema; Participate in the blood clotting process, labile factor I promptly is Ca2+; Participate in the activation of many enzyme systems (as: ATP enzyme, succinic acid deaminase, lipase, protease etc.) in the body; The macromole that participates in cellular metabolism enzyme synthetic, that change there is regulating action; Relevant with normally beating of the conduction of the generation of neuromuscular excitement, neural impulse, heart; And calcium, magnesium, potassium, sodium keep certain proportion be promote muscle contraction, to keep nervomuscular irritability necessary, if calcium ion concentration descends in the blood, it is too excited that nervous tissue will become, and causes tetany, on the other hand, hypercalcemia then suppresses neural excitation.In addition, calcium participates in hormone in vivo secretion in addition, keeps function such as body fluid acid-base balance.
The many physiological actions of Ca2+ in cell nearly all are to be undertaken by the form that combines with some special protein (receptor), as calmodulin, CaM: the concentration of Ca2+ is 10.7～10.6mol/L in the akinete slurry, at this moment, Ca2+ can not combine with calmodulin, CaM; When cell is upset, Ca2+ concentration increases and reaches 10.6mol/L or when higher, calmodulin, CaM promptly is combined into complex with Ca2+, and calmodulin, CaM is with after Ca2+ combines specifically, and conformation changes, and the complex of Ca2+ and calmodulin, CaM can play a role.Therefore, Ca2+ is not only the moderator of muscle contraction, still is a kind of important second message,second messenger's material simultaneously.
In meals, be unfavorable for that the absorption factor of calcium has: 1. phytic acid in the food and oxalic acid can be combined into the absorption that insoluble calcium salt influences calcium with calcium.Phytic acid is an inositol hexaphosphate, and content is more in the Cereals based food, and some vegetable oxalic acid is more.Some vegetable not only self contained calcium can not be absorbed and used, and also has influence on the absorption of calcium in other food of taking in simultaneously, as Herba Spinaciae, Herba Amaranthi tricoloris Lay, Caulis et Folium Ipomoeae aquaticae, Folium Colocasiae Esculentae dish etc.2. contain too much alkaline phosphate etc. in some foods, in enteric cavity, be combined into insoluble calcium salt, can reduce the absorption of calcium with calcium.3. too high fat is taken in or dyspepsia, can be combined into insoluble calcium soap thing owing to abundant fatty acid and calcium, and from feces, discharge, serve as obvious (this process also can cause losing of fatsoluble vitamin D) to contain the more oils and fats of unsaturated fatty acid especially, cause that calcium absorption reduces.4. the uronic acid residue in the dietary fiber combines with calcium, forms the absorption that insoluble matter also influences calcium.5. taking in protein in a large number also can make urine calcium discharge increase.6. the dietary calcium phosphorus ratio is lower than at 1: 2 o'clock, calcium from skeleton dissolving and deviate to increase, can cause osteoporosis when serious.The factor that helps the absorption of calcium has: 1. vitamin D is the principal element that promotes calcium absorption.2. some aminoacid such as lysine, tryptophan, arginine etc. can form soluble calcium salt with calcium, help calcium absorption.3. lactose can become the low molecular weight soluble material with the calcium chelating, promotes the absorption of calcium.In addition, when big, the absorbance of calcium increases human body to the requirement of calcium, otherwise then absorbance reduces.Therefore, when selecting food for use, should note the content of its oxalic acid and phytic acid, and adopt adequate measures to remove the factor that hinders calcium absorption to utilize; Avoid Herba Spinaciae, three-coloured amaranth etc. and bean curd, milk, high fat diet meal together, also want polyphagia to be rich in the food of vitamin D simultaneously.
When taking in the calcium quantity not sufficient, cause that at child Chang Ke growth retardation, new abnormal bone structure, bone calcification are bad, rickets appears in textured bone.Reversible physiological function obstacle just takes place at the calcium deficiency initial stage in common people, and premature beat, emotional lability, sleep quality decline appear in heart.Long-term calcium Deficiency of Intake when blood calcium drops to finite concentration, causes that parathyroid hormone secretion strengthens, mobilize bone calcium to enter blood, the skeleton decalcification causes osteoporosis, just may occur fracture under very little external force effect, spinal bone also is difficult to bear body wt and compression.To middle-aged and elderly people, in the osteoporotic while of calcium deficiency, also hyperosteogeny may appear, when bone calcium enters blood, blood calcium concentration rises, and stimulates the secretion increasing of parafollicular cell to calcitonin, calcitonin is strengthened osteogenetic process, calcium phosphorus deposition increases, and quickens the formation of new bone, brings out existing hyperosteogeny or bony spur in the joint.Crowd's epidemiological survey shows that hypertensive patient's calcium intake is lower, and the generation of some hypertension is relevant with the calcium Deficiency of Intake.To middle-aged and elderly people, because after a large amount of bone calcium of effect of parathyroid hormone enter blood, be deposited on soft tissues such as blood vessel wall on the one hand, vascular smooth muscle cell is changed to the Ca2+ permeability, Ca2+ increases in the cell, cell occurs physically different, causes the vascular smooth muscle persistence to be shunk, and arteriotony is raise.In addition, high calcium can reduce blood plasma cholesterol level in the meals, occurs thereby suppress atherosclerosis.
Calcium is relevant with human tumor, studies show that the high calcium meals have the effect of preventing colon cancer to take place, the male that the high male of calcium absorption level and absorption level are low compares, and the danger of suffering from colon cancer is low, and this may have inhibitory action relevant to the hyperplasia of human colon's mucomembranous epithelial cell with calcium.
In addition, low blood calcium tetany, renal calculus can occur when the human body blood calcium concentration is low, can cause when serious that the respiratory muscle spasm causes suffocates.
The absorption of calcium is relevant with the age.Its absorbance descends with age, and the baby surpasses 50% to the absorbance of calcium, and the child is about 40%, and the adult only is 20%.After general 40 years old, the absorption of calcium descends gradually, and old people's sclerotin is loose gradually relevant therewith.Osteoporosis be with the bone amount reduce, the chemical constituent of osseous tissue is unusual, the microstructure degeneration changes and the danger of fracture to increase be feature.Its clinical manifestation is weakness, lumbar and back pain, textured bone.Can not have tangible subjective symptoms in early days, it normally slips into lentamente in the body and not for discovering, has only when deossification reaches 30%, just may occur bow-backed and whole body becomes short situation, normal so and the generation osteoporotic fracture of a lot of patients.Osteoporosis mainly is divided into two big classes: i.e. primary osteoporosis and secondary osteoporosis.Secondary osteoporosis brings out owing to some disease or some reason often, primary osteoporosis be since the age increases or postmenopausal women after a kind of physiological of taking place of osseous tissue change.Also have a kind of agnogenic idiopathic osteoporosis disease, mostly occur between twenty and fifty or juvenile, this case has hereditary family history more.But no matter be congenital, day after tomorrow, former, secondary, all in close relations with calcium deficiency.The patient at first is a forfeiture bone matrix, decalcification gradually.So rare at ordinary times sunlight or hepatorenal disease can not generate 1 in the body, 25-dihydroxy vitamin D influences alcium and phosphor metabolization; Menopausal women estrogen reduces; The decline of old people's hepatic and renal function all can make 1, and 25-dihydroxy vitamin D generates minimizing, causes the calcium intake deficiency, so both of these case causes osteoporosis especially easily.Owing to osteoporosis is also lacked effective treatment, just is difficult to recover in case fracture takes place.Therefore, prevention of osteoporosis is more important than treatment.Great majority research shows that behind the bone loss relevant with age or menopause, increase calcium replenishes and can only play the minimizing bone loss, keeps the flat effect of bone water gaging, can not effectively and constantly increase the bone amount.And to reduce osteoporotic incidence rate, scholars generally believe, life early stage (childhood period, adolescence, grow up early stage) by rational nutrition with temper the peak-peak bone amount that obtains the heredity regulation, it is the best measure of prevention later stage of life osteoporosis, and its bone density height of people that high calcium is taken in, when progressing into old age, then can postpone and prolong the process of calcium loss in the skeleton, and then be difficult for fracturing.
Pharmacological action
This product is calsium supplement and important bone metabolism regulator,, have the effect that promotes that skeleton and tooth calcification form, keep the NE of human nerve and muscle and the permeability of reduction blood capillary.
The indication medicine of replenishing the calcium.Be used for prevention and treatment calcium deficiency, be applicable to gestation, nursing women, crowds such as old man, child replenish the calcium and osteoporotic treatment.In also can be used for and gastric acid.
(4) ferrous lactate
Pharmacological toxicology
Ferrum is the ferrum element supplement.Ferrum is the main constituent of hemoglobin and Myoglobin.Hemoglobin is the person that mainly takes oxygen in the erythrocyte, and Myoglobin is the position that muscle cell is stored oxygen, and the needs of oxygen are provided during for muscular movement.With tricarboxylic cycle relevant most of enzymes and the equal iron content of the factor, or only when existing, ferrum just plays a role.Body lacks ferrum, can cause the relevant symptom of iron deficiency anemia or other various iron deficiencies, and as growth retardation, dystropy is short of physical strength, mucosal tissue variation and skin, fingernail pathological changes etc.
Pharmacokinetics
This product is oral mainly to be absorbed at descendant duodenum and jejunum near-end.Ferrum absorbs the back and enters blood circulation after transferrins combines, and is used for making erythrocyte, also can ferritin or the hemosiderin form be stored in liver, spleen, bone marrow and other monokaryons-huge biting in the system, oral chalybeate can not all be discharged with feces from intestinal absorption person.Through the ferrum of organism metabolism, mainly, also drain a part through sweat gland and epithelial cell by renal excretion.Oral chalybeate can not all be discharged with feces from intestinal absorption person.
(5) vitamin A
Pharmacological toxicology
This product is a vitamin drug.Have promote growth, keep epithelial tissue such as skin, the effect of normal functions such as conjunctiva, cornea, and participate in the synthetic of rhodopsin, strengthen retina sensitization power; Participate in the oxidation of many oxidizing processs, especially unsaturated fatty acid in the body.During vitamin A deficiency, then growth stops, and skeleton is grown up bad, the reproductive function decline, and pachylosis, drying, keratomalacia, and drying property ophthalmia and nyctalopia take place.
Pharmacokinetics
Oral very easily absorption, fat, protein and intravital cholate and vitamin E are absorbed with substantial connection to vitamin A in the food, lack above-mentioned substance and then absorb reduction.Be stored in after the absorption in the liver, almost all metabolism decomposition in vivo, and by urine and feces discharge.The nursing women has the part vitamin A to secrete in milk.
(6) vitamin B12
Vitamin B12 is cobalamine again, is a kind of water soluble vitamins.Plant can not be made vitamin B12, and it is a kind of special gastro-intestinal secretion things of unique needs, just the vitamin that is absorbed by human body; Its time of staying in intestinal is long, approximately needs three hours (most of water soluble vitamins only need several seconds).
The major physiological function of vitamin B12
1. promote erythrocytic formation and regeneration, make the human body hematopoietic function be in normal condition, the prevention pernicious anemia.
2. promote carbohydrate, fat and protein metabolism, fat, carbohydrate, protein are suitably in the body utilize;
3. eliminate dysphoria; Impel attention to concentrate, promote memory and equilibrium sense, keep neural normal function;
4. have the effect of activated amino acid and promote the proteinic synthetic of nucleic acid, it plays an important role to the growth promoter of infant.
The symptom of vitamin B12 deficiency and toxicity thereof
The vegetarian, pernicious anemia is partly or entirely excised the phenomenon that stomach operation and parasite such as infect at the B12 that all might occur being deficient in vitamin.The be deficient in vitamin common sympton of B12 of meals is: weakness, and loss of weight, backache, extremity tingle, and expression is dull, and spirit or other are off one's dot.Also might cause anemia, but very rare.Known vitamin B12 does not have toxicity.
Pharmacological toxicology
This product is an anti-anemic drug. vitamin B12 participates in methyl conversion and folic acid metabolism in the body, promote the 5-methyl tetrahydrofolate to change tetrahydrofolic acid into. during shortage, cause the DNA dyssynthesis, influencing erythrocytic maturation. this product also impels Isosuccinic acid to change succinic acid into, participating in tricarboxylic acid cycle. this interactively is to the synthetic of neurospongium sphingolipid and keep the myelinated nerve fiber telotism, and the nervous lesion of vitamin B12 deficiency disease may be relevant therewith.
Pharmacokinetics
The intramuscular injection post-absorption is rapid and complete, about 1 hour blood drug level peaking; Distributed more widely in the body, but mainly be stored in liver, adult's total storage is 4 (5mg; Most of 8 hours through renal excretion, dosage is bigger, drains the more.
Indication
Be mainly used in because of the megaloblastic anemia of intrinsic factor due to lacking, also can be used for the SACD nervous system lesion, as neuritic auxiliary treatment.
(7) vitamin C
Vitamin C is ascorbic acid again, is a kind of water soluble vitamins.Vitamin C major physiological function
1, promotes the biosynthesis of ossein.Be beneficial to the faster healing of tissue injury mouth;
2, the metabolism of tyrosine and tryptophan in the promotion aminoacid prolongs the human body life-span.
3, improve the utilization of ferrum, calcium and folic acid.
4, improve the particularly metabolism of cholesterol of fat and lipoid, the prevention cardiovascular diseases.
5, promote tooth and skeletal growth, prevent that dental bed is hemorrhage.；
6, strengthen the human body anti-stress ability and the immunity of environment to external world
Pharmacological toxicology
Vitamin C is that antibody and collagen form, tissue repairing's (comprising some redox), the metabolism of phenylalanine, tyrosine, folic acid, the utilization of ferrum, carbohydrate, fatty, proteinic synthetic, keep immunologic function, hydroxylation and hydroxytryptamine, keep the complete of blood vessel, institutes such as promotion nonheme iron absorption are essential.
Pharmacokinetics
Gastrointestinal absorption is mainly at jejunum.Protein binding rate is low.Higher with content in gland tissue, leukocyte, liver, the eyeglass.When human body is taken in vitamin C and recommended requirement every day, store 1500mg in the body approximately, when taking in the 200mg vitamin C every day, the about 2500mg of reserves in the body.Intrahepatic metabolism, minute quantity with original shape or metabolite through renal excretion.When plasma concentration during greater than 14 μ g/ml, output, increase in the urine.Can remove through the blood dialysis.
(8) vitamin D
3
Pharmacological toxicology
This product is a vitamin drug.Vitamin D2 promotes the small intestinal mucosa brush border that the absorption and the renal tubules of calcium are heavily absorbed phosphorus, increasing blood calcium, serium inorganic phosphorus concentration, and collaborative parathyroid hormone, calcitonin promote old bone to discharge calcium phosphate, keep and regulate plasma calcium, phosphorus normal concentration.Vitamin D2 impels calcific deposit in new bone formation position, and citrate is deposited in bone, promotes bone calcification and function of osteoblast and osteoid tissue maturation.After vitamin D2 is taken in, in cytomicrosome, be subjected to the catalysis of 25-hydroxylase system to generate calcifediol (25-OHD3),, generate the calcitriol (1-25-(OH) 2D3) of biologically active through the catalysis of renal proximal tubular cell 1-hydroxylase system.
Pharmacokinetics
The metabolism of vitamin D3, activation at first by liver, are kidney secondly.T1/2 is 19-48 hour, but in fatty tissue long term store.
(9) folic acid
Pharmacological toxicology
The water solublity vitamin B group that folic acid system is made up of the residue of pteridine, para-amino benzoic acid and glutamic acid is body cell growth and the necessary material of breeding.Be present in liver, kidney, yeast and greenery vegetables such as beans, Herba Spinaciae, Fructus Lycopersici esculenti, the Radix Dauci Sativae etc., now can manually synthesize.Folic acid is through the effect of dihydrofolate reductase and vitamin B12, form tetrahydrofolic acid (THFA), the latter and multiple one carbon unit (comprising CH3, CH2, CHO etc.) are combined into tetrahydrofolic acid class coenzyme, transmit one carbon unit, participate in a lot of important reactions and nucleic acid and amino acid whose synthetic in the body.THFA forms N5 under the effect of serine transhydroxylation enzyme, 10 methene tetrahydrofolic acids can impel uridylate (dUMP) to form thymidylic acid (dTMP), and the DNA that the latter can participate in cell synthesizes, and the division that promotes cell is with ripe.In the DNA building-up process, deoxyuridylic acid changes deoxythymidylic acid into, and required therebetween methyl is provided by methylene tetrahydrofolate.During folic acid deficiency, DNA is synthetic to slow down, but RNA is synthetic unaffected, and result's cellulation volume in bone marrow is big and nucleus is grown inmature hemocyte, and the most obvious with erythrocyte especially, in time replenishing to have the treatment effect.
Pharmacokinetics
Mainly absorb at the jejunum near-end with the reduction pattern after oral, promptly came across in the blood in 5～20 minutes, reach the peak after one hour, its t1/2 is about 0.7 hour.Anemia patient's infiltration rate is fast than the normal person.Folic acid enters liver by portal vein, is stored in the liver neutralization with the form of N5-methyl tetrahydrofolate and is distributed to other histoorgans, and storage capacity is about 1/3～1/2 of whole body total amount in liver.The folic acid of therapeutic dose about 90% is drained in urine, behind the large bolus injection 2 hours, promptly has 20%～30% to come across in the urine.Indication
(1) folic acid deficiency that causes of a variety of causes and the megaloblastic anemia due to the folic acid deficiency;
(2) trimester of pregnancy, women breast-feeding their children prevent administration;
(3) folic acid deficiency due to the chronic hemolytic anemia;
(10) chlorhematin
Pharmacological toxicology
This product is the ferrum element supplement.Ferrum is the main constituent of hemoglobin and Myoglobin.Hemoglobin is the person that mainly takes oxygen in the erythrocyte, and Myoglobin is the position that muscle cell is stored oxygen, and the needs of oxygen are provided during for muscular movement.With tricarboxylic cycle relevant most of enzymes and the equal iron content of the factor, or only when existing, ferrum just plays a role.Body lacks ferrum, can cause the relevant symptom of iron deficiency anemia or other various iron deficiencies, and as growth retardation, dystropy is short of physical strength, mucosal tissue variation and skin, fingernail pathological changes etc.
Pharmacokinetics
Mainly absorb after this product is oral at descendant duodenum and jejunum near-end.Ferrum absorbs the back and enters blood circulation after transferrins combines, and is used for making erythrocyte, also can ferritin or the hemosiderin form be stored in liver, spleen, bone marrow and other monokaryons-huge biting in the system, oral chalybeate can not all be discharged with feces from intestinal absorption person.Through the ferrum of organism metabolism, mainly, also drain a part through sweat gland and epithelial cell by renal excretion.Oral chalybeate can not all be discharged with feces from intestinal absorption person.
(11) zinc citrate
Pharmacological action
This product is a zinc supplement.Zinc participates in the synthetic of plurality of enzymes and activates,, intestinal proteic absorption synthetic to protein, nucleic acid and digestion performance important physiological function.Zinc can promote growth promoter; By to the synthetic of gustin in the taste bud and prevent that cheek mucosal epithelium cellular keratinization is incomplete, keep the normal appetite and the sense of taste; Strengthen phagocyte phagocytic activity, chemotactic vigor and sterilizing function; And reduce free radical by increasing superoxide dismutase; The performance bactericidal action, acceleration of wound, burn, ulcer healing; Zinc plays an important role to the metabolism and the vision of vitamin A; Promote and the maintenance function; Stabilizing cell membrane; Improve and organize energy metabolism and Tissue respiration; Zinc ion can precipitating proteins.
Pharmacokinetics
Zinc salt absorbs few at stomach, mainly by duodenum and little intestinal absorption, go into mostly behind the blood to combine with serum albumin; Mainly discharged by feces, trace is discharged by urine, antiperspirant, desquamation, alopecia.
Indication
Be used for the anorexia that zinc deficiency causes, anemia, growth retardation, nutritional dwarf and acrodermatitis enteropathica.The auxiliary treatment that also can be used for pica, rheumatoid arthritis, intermittent claudication, hepatolenticular degeneration (be applicable to and use penicillamine person), acne, chronic ulcer, conjunctivitis, aphtha etc.
Adnexa 2. embodiment 2: the clinical efficacy research of compound colla carapaeis corii asini series products
The 112 routine clinical observations of Colla Corii Asini folic acid vitamin B12 sheet treatment iron deficiency anemia
Iron deficiency anemia is a common disease, also is the type of seeing at most in the anemia.It can be a kind of independently disease, and mostly is that symptom as other disease occurs.Iron deficiency anemia diagnosis and treatment are not difficult, but clinically improvement of satisfying Anemia more, and dispel the cause of disease and lasting regular treatment is paid little attention to.This not only can cause the Anemia recurrence, also can cause the protopathy mistaken diagnosis.This paper carries out clinical analysis to 112 routine iron deficiency anemias of my institute's diagnosis and treatment in 2000～2005 years.
1. clinical data
Select Patients with iron deficiency anemia 112 examples, man's 26 examples, woman's 86 examples, the man: the woman is 1: 3.3,3～62 years old age, meet following diagnostic criteria: 1. microcytic hypochromic anemia: male Hb＜120g/L, woman Hb＜110g/L, MCV＜80fl, MCH＜26pg, there is obviously low pigment sex expression MCH＜0.31, red cell morphology.2. have clear and definite Fe deficiency symptoms because of and clinical manifestation.3. serum levels of iron (SI).＜8.95 μ mol/L, total iron binding capacity＞64.44 μ mol/L.4. transport ferrum saturation＜0.15.5. bone marrow iron stain shows that the bone marrow granule can dye ferrum and disappear sideroblast＜15%.6. serum ferritin (SF)＜14 μ g/L.7. the chalybeate treatment effectively.
Meet in the 1st and 2～7 that any 2 persons are diagnosable to be iron deficiency anemia.
1.1 the cause of disease and severity of anemia classification
Anemia (22 examples of Hb 〉=90g/L), anemia (64 examples of Hb:60g～89g/L), and anemia (26 examples of Hb:30g～59g/L), wherein moderate and above anemia thereof account for 80.36%, and the cause of disease sees Table 1.
The table 1 112 routine iron deficiency anemia cause of disease and severity of anemia
| The cause of disease | The men and women | Slightly | Severity of anemia | Amount to | Account for sum (%) | |
| Moderate | Severe | |||||
| Infantile anemia | 5 7 | 5 | 7 | 12 | 10.71 | |
| Menorrhagia | 42 | 5 | 21 | 16 | 42 | 37.5 |
| Anemia during pregnancy | 26 | 7 | 19 | 26 | 23.21 | |
| Hemorrhagic anemia | 14 | 14 | 14 | 12.5 | ||
| Monophagia | 4 11 | 5 | 10 | 15 | 13.39 | |
| Other | 3 | 3 | 3 | 2.68 | ||
| Add up to | 9 103 | 22 | 60 | 30 | 112 | 100.0 |
1.2 administrated method
112 routine patients are divided into two groups of treatment group, matched groups at random, and the treatment group gives oral Colla Corii Asini folic acid vitamin B12 sheet, each 2, three times on the one.4 weeks were 1 course of treatment.The matched group Colla Corii Asini capsule is oral, 6 of children's one time, 3 times on the one; Be grown up one time 9,2 times on the one.4 weeks were 1 course of treatment, continuous two courses of treatment.
1.3 observation index
All all carry out hematological indices before and after the patient treatment and measure, comprise hemoglobin (Hb), mean corpuscular volume (MCV) (MCV), serum levels of iron (SI), serum ferritin (SF).Treatment simultaneously, the record patient gastrointestinal reaction comprises nauseating, abdomen account, vomiting, acid regurgitation, pain, stomach discomfort, diarrhoea etc.
The anemia group is followed up a case by regular visits to 2 times before medication and after the medication.The anemia group is followed up a case by regular visits to 3 times before medication, after 4 weeks of medication, 4 weeks of medication altogether.During medication, there is any situation all can go to a doctor at any time.Follow up a case by regular visits to and comprise clinical symptoms and sign, blood one biochemical detection, peripheral blood kinetics etc.
2. hematological indices sees Table 2 before and after two groups of patient treatments of result
Hematological indices relatively before and after the table 2 liang group treatment
| Group | The example number | Before the treatment | After the treatment | ||||||||
| Hb (g/L ) | MCV (fI ) | SI (μ mol) | SF (ug /L) | Hb (g/L) | SI (μmol) | SF (μg/L) | |||||
| One month | Two months | One month | Two months | One month | Two months | ||||||
| Matched group | 40 | 75.5 ± 18.5 | 68.1 3± 6.64 | 4.6 ±2.2 | 9.17 ± 4.59 | 95.4 ± 15.6. | 105.5 ± 12.1 | 7.8± 5.6 | 10.8 ±6.6 | 30.05 ± 20.1 | 50.43 ± 42.02 |
| The treatment group | 72 | 73.8 ± 19.4 | 66.5 4± 6.81 | 4.5 ±1.8 | 8.77 ± 4.49 | 112.6 ± 16.0 | 125.4 ±8.8 | 11.8 ±6.6 | 13.9 ±6.4 | 31.72 ± 21.17 | 70.59 ± 50.22 |
The result
1. before and after two groups of hematological indices difference treatments significance meaning (P＞0.05) is arranged.Treatment group treatment iron deficiency anemia curative effect is better than matched group.
2. in the treatment observation process, matched group has 8 examples to take Colla Corii Asini capsule, takes place to feel sick, gastrointestinal reactions such as vomiting, stomach discomfort, and gastrointestinal reaction is not found in treatment, comprise nauseating, abdomen account, vomiting, acid regurgitation, pain, etc. stomach discomfort.
Discuss
(iron deficiency anemia is to influence the nutritional anemia that the synthetic caused a kind of common iron deficiency of hemoglobin causes owing to lacking irony in the body IDA) to iron deficiency anemia.This anemia characteristics are to lack the ferrum that can dye in bone marrow, liver, spleen and the hetero-organization thereof, and serum iron and serum transferrin saturation all reduce.
According to World Health Organization's investigation report, the whole world has 10%～30% crowd that in various degree iron deficiency is arranged approximately.Male's sickness rate is about 10%, and the women is greater than 20%.The Asia sickness rate is higher than Europe.There is the half women in the third world owing to malnutrition is suffered from anemia, is called nutritional anemia.Women particularly anemia of pregnant woman's incidence rate is higher 10 times than the male possibly.A good appetite suddenly appearing in a serious disease is external, among developing national 400,016,400 women of child-bearing age, 200,013,000 women morbidity is arranged approximately, and wherein the anemia of pregnant woman accounts for 60%～80%.Secondly underfed main diseases is to lack vitamin B12 because of at first being iron deficiency.As seen, the morbidity region is so wide, and the ill numeral of women is so big, and is very surprising, significant.Prevent and treat malnutritional anemia, become the problem of worldwide concern.. area, Shanghai high-risk group's investigation of clinical epidemiology shows: menstrual phase women, gravid woman and teenager iron deficiency anemia prevalence are respectively 11.39% 19.28% and 9.84%, the iron deficiency prevalence is respectively 43.3%, 66.27% and 13.17%;
One of finishing of attached first hospital of Jinan University Medical School discovers: child's folic acid deficiency anemia is more than iron deficiency anemia, and various trace elements lacks closely related in the outbreak of anemia and the body.Discover, in the infant of nutritional anemia, the folic acid deficiency person is 48.1%, apparently higher than iron deficiency person's 27.85%, and folic acid deficiency children's's onset peak also obviously prolongs than iron deficiency children's, the understanding of " neonatal anemia is mainly caused by iron deficiency " has been corrected in this discovery, and more explanation adds in time and scientifically that diatery supplement particularly adds the food that contains folic acid, the educating knowledge of popularizing science is very important.
Result of study to the nutritional anemia reason shows: have micronutrient levelss such as ferrum in 85% the nutritional anemia neonate serum, copper, zinc to reduce, and, when simple employing chalybeate is treated iron deficiency anemia, part children's's unsatisfactory curative effect, and adding trace element such as zinc agent simultaneously when treating, the anemia situation is improved.This shows that the generation of iron deficiency anemia and some trace element deficiency are closely related.
Colla Corii Asini folic acid vitamin B12 tablet recipe is made up of Colla Corii Asini, folic acid, vitamin B12, vitamin A, vitamin C, ferrous lactate, dextrinosan-900.Colla Corii Asini contains multiple several amino acids, and experimentation proves, Colla Corii Asini can promote the generation of erythrocyte and hemoglobin in the blood, and effect is better than ferrum; The water solublity vitamin B group that folic acid system is made up of the residue of pteridine, para-amino benzoic acid and desire propylhomoserin is that body cell growth and breeding must materials.Acid is through the effect of dihydrofolate reductase and vitamin B12, form tetrahydrofolic acid (THFA), the latter and multiple one carbon unit (comprising CH3, CH2, CHO etc.) are combined into tetrahydrofolic acid class coenzyme, transmit one carbon unit, participate in a lot of important reactions and nucleic acid and amino acid whose synthetic in the body.THFA passs at serine under the effect of hydroxyl enzyme, forms N5,10 methene first hydrogen folic acid, and the division that promotes cell is with ripe.In the DNA building-up process, deoxyuridylic acid changes deoxythymidylic acid into, and required therebetween methyl is provided by methylene tetrahydrofolate.During folic acid deficiency, DNA is synthetic to slow down, but RNA is synthetic unaffected, and result's cellulation volume in bone marrow is big and nucleus is grown inmature hemocyte, and the most obvious with erythrocyte especially, in time replenishing to have the treatment effect.Vitamin B12 is Vitamin again, and vitamin B12 participates in methyl conversion and folic acid metabolism in the body, promotes the 5-methyl tetrahydrofolate to change tetrahydrofolic acid into.During shortage, cause the DNA dyssynthesis, influence erythrocytic maturation.This product also impels Isosuccinic acid to change succinic acid into, participates in tricarboxylic acid cycle.This interactively is to the synthetic of neurospongium sphingolipid and keep the myelinated nerve fiber telotism, and the nervous lesion of vitamin B12 deficiency disease may be relevant therewith.Vitamin C is ascorbic acid again, is a kind of water soluble vitamins.Vitamin C is that antibody and collagen form, tissue repairing's (comprising some redox), the metabolism of phenylalanine, tyrosine, folic acid, the utilization of ferrum, carbohydrate, fatty, proteinic synthetic, keep immunologic function, hydroxylation and hydroxytryptamine, keep the complete of blood vessel, institutes such as promotion nonheme iron absorption are essential.Vitamin C can improve the utilization of ferrum, calcium and folic acid, strengthens the human body anti-stress ability and the immunity of environment to external world.The inferior chemical name of lactic acid is the ferrous trihydrate of α-Qiang Jibingsuan, is to generate with reactions such as lactic acid, calcium carbonate, ferrous sulfate, and ferrous lactate has remarkable result to control and treatment iron deficiency anemia, to the gastrointestinal nonirritant.Bacillus bifidus has splendid cultivation effect in the dextrinosan-900 pair human body intestinal canal, and enhancing human body immunity power may promote intestinal ferrum to absorb, and improves clinical therapeutic efficacy, in this treatment observation process, does not find toxicity, and suggestion is applied.
List of references:
1. the 99.4.2 Yuan Li that " lives with healthy " is new etc.
Claims (9)
1. the prescription of compound colla carapaeis corii asini series products and manufacture method are with Colla Corii Asini, dextrinosan-900, calcium carbonate, ferrous lactate, vitamin A, vitamin B
12, vitamin C, vitamin D
3, folic acid, chlorhematin, zinc citrate is material composition, according to different physiologically actives, science is formed the prescription of compound colla carapaeis corii asini series products, through pulverize, extract, processing, make tablet or capsule.
2. require described composition according to right 1, form Colla Corii Asini qi iron plate or capsule formula (1), it is characterized in that being: Colla Corii Asini 40～80%, ferrous lactate 0.6～1.2%, vitamin C 0.35～0.70%, vitamin A 0.007～0.014%, dextrinosan-900 15～30% by its prescription preparation percentage by weight.
Colla Corii Asini qi iron plate or capsule formula (1) preparation method is characterized in that, gets Colla Corii Asini, ferrous lactate, vitamin C, dextrinosan-900 pulverize separately and becomes fine powder, sieves, and adds right amount of auxiliary materials, mixes, and granulates drying, tabletting, coating; Or divide encapsulated.
3. require described composition according to right 1, form Colla Corii Asini qi iron plate or capsule formula (2), it is characterized in that being: Colla Corii Asini 40～80%, chlorhematin 1.5～3.0%, vitamin C 0.35～0.70%, vitamin A 0.012～0.024%, dextrinosan-900 15～30% by its prescription preparation percentage by weight.
Colla Corii Asini qi iron plate or capsule formula (2) preparation method is characterized in that, gets Colla Corii Asini, chlorhematin, vitamin C, vitamin A, dextrinosan-900 pulverize separately and becomes fine powder, sieves, and adds right amount of auxiliary materials, mixes, and granulates drying, tabletting, coating; Or divide encapsulated.
4. require described composition according to right 1, form Colla Corii Asini fork D calcium iron plate or capsule formula (1), it is characterized in that being: Colla Corii Asini 30～50%, calcium carbonate 20～40%, ferrous lactate 0.7～1.4%, vitamin A 0.008～0.0016%, vitamin C 0.5～1%, vitamin D by its formulated percentage by weight
30.00003 dextrinosan-900 10～20%～0.00006%.
Colla Corii Asini fork D calcium iron plate or capsule formula (1) preparation method is characterized in that, get Colla Corii Asini, calcium carbonate, ferrous lactate, vitamin A, vitamin C, vitamin D
3Dextrinosan-900 pulverize separately becomes fine powder, sieves, and adds right amount of auxiliary materials, mixes, and granulates drying, tabletting, coating; Or divide encapsulated.
5. require described composition according to right 1, form Colla Corii Asini fork D calcium iron plate or capsule formula (2), it is characterized in that being by its prescription preparation percentage by weight: Colla Corii Asini 30～50%, calcium carbonate 18～36%, chlorhematin 2～4%, vitamin A 0.008～0.016%, vitamin C 0.5～1%,, vitamin D
30.00004 dextrinosan-900 10～20%～0.00008%.
Colla Corii Asini fork D calcium iron plate or capsule formula (2) preparation method is characterized in that, get Colla Corii Asini, calcium carbonate, chlorhematin, vitamin A, vitamin C, vitamin D
3Dextrinosan-900 pulverize separately becomes fine powder, sieves, and adds right amount of auxiliary materials, mixes, and granulates drying, tabletting, coating; Or divide encapsulated.
6. require described composition according to right 1, form Colla Corii Asini calcium ferrum zinc metal sheet or capsular prescription (1), it is characterized in that being: Colla Corii Asini 30～60%, calcium carbonate 15～30%, ferrous lactate 1.2～2.4%, vitamin D by its prescription preparation percentage by weight
30.00005～0.0001%, vitamin C 0.7～1.4%, zinc citrate 0.7～1.4%, dextrinosan-900 15～30%.
Colla Corii Asini calcium ferrum zinc metal sheet or capsular prescription (1) preparation method is characterized in that: get Colla Corii Asini, calcium carbonate, ferrous lactate, vitamin D
3, vitamin C, zinc citrate, dextrinosan-900 pulverize separately become fine powder, sieves, and adds right amount of auxiliary materials, mixes, and granulates drying, tabletting, coating; Or divide encapsulated.
7. require described composition according to right 1, form Colla Corii Asini calcium ferrum zinc metal sheet or capsule formula (2), it is characterized in that, by its prescription preparation percentage by weight be: Colla Corii Asini 30～60%, calcium carbonate 15～30%, chlorhematin 3～6%, vitamin D
30.00005 vitamin C C0.7～1.4%～0.0001%,, zinc citrate 0.7～1.4%, dextrinosan-900 15～30%.
Colla Corii Asini calcium ferrum zinc metal sheet or capsule formula (2) preparation method is characterized in that: get Colla Corii Asini, calcium carbonate, chlorhematin, vitamin D
3, vitamin C, zinc citrate, dextrinosan-900 pulverize separately become fine powder, sieves, and adds right amount of auxiliary materials, mixes, and granulates drying, tabletting, coating; Or divide encapsulated.
8. require described composition according to right 1, form Colla Corii Asini iron folic acid vitamin B
12Sheet or capsular prescription (1) is characterized in that, by its prescription preparation percentage by weight are: Colla Corii Asini 33～66%, folic acid 0.0044～0.0088%, vitamin B
120.00018～0.00036%, ferrous lactate 1.5～2.6%, rope C1.5～3.0% of supporting one's family, dextrinosan-900 25～50%.
Colla Corii Asini iron folic acid vitamin B
12Sheet or capsule formula (1) preparation method is characterized in that: get Colla Corii Asini, folic acid, vitamin B
12, ferrous lactate, vitamin C, dextrinosan-900 pulverize separately become fine powder, sieves, and adds right amount of auxiliary materials, mixes, and granulates drying, tabletting, coating; Or divide encapsulated.
9. require described composition according to right 1, form Colla Corii Asini iron folic acid vitamin B
12Sheet or capsule formula (2) is characterized in that, by its prescription preparation percentage by weight are: Colla Corii Asini 33～66%, folic acid 0.0044～0.0088%, vitamin B
120.00018～0.00036%, chlorhematin 3.5～7%, vitamin C 1.6～3.2%, dextrinosan-900 25～50%.
Colla Corii Asini iron folic acid vitamin B
12Sheet or capsule (2) preparation method is characterized in that, gets Colla Corii Asini, folic acid, vitamin B
12, chlorhematin, vitamin C, dextrinosan-900 pulverize separately become fine powder, sieves, and adds right amount of auxiliary materials, mixes, and granulates drying, tabletting, coating; Or divide encapsulated.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200610126420XA CN101129406A (en) | 2006-08-24 | 2006-08-24 | Formula of compound colla carapaeis corii asini series products and method for producing the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200610126420XA CN101129406A (en) | 2006-08-24 | 2006-08-24 | Formula of compound colla carapaeis corii asini series products and method for producing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101129406A true CN101129406A (en) | 2008-02-27 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA200610126420XA Pending CN101129406A (en) | 2006-08-24 | 2006-08-24 | Formula of compound colla carapaeis corii asini series products and method for producing the same |
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| CN (1) | CN101129406A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101965979A (en) * | 2010-06-30 | 2011-02-09 | 安徽万山生物科技有限公司 | Calcium lysinate donkey-hide gelatin freeze-dried powder capsule and production technique thereof |
| CN103535823A (en) * | 2013-09-27 | 2014-01-29 | 刘宗银 | Oligosaccharide/donkey-hide gelatin/red skin health drink and preparation method thereof |
| CN103535578A (en) * | 2013-09-27 | 2014-01-29 | 刘宗银 | Oligosaccharide/donkey-hide gelatin/red skin oral liquid and preparation method thereof |
| CN104799277A (en) * | 2015-03-31 | 2015-07-29 | 山东福胶集团东阿镇阿胶有限公司 | Chewable colla corii asini tablet and preparation method thereof |
-
2006
- 2006-08-24 CN CNA200610126420XA patent/CN101129406A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101965979A (en) * | 2010-06-30 | 2011-02-09 | 安徽万山生物科技有限公司 | Calcium lysinate donkey-hide gelatin freeze-dried powder capsule and production technique thereof |
| CN103535823A (en) * | 2013-09-27 | 2014-01-29 | 刘宗银 | Oligosaccharide/donkey-hide gelatin/red skin health drink and preparation method thereof |
| CN103535578A (en) * | 2013-09-27 | 2014-01-29 | 刘宗银 | Oligosaccharide/donkey-hide gelatin/red skin oral liquid and preparation method thereof |
| CN103535578B (en) * | 2013-09-27 | 2015-09-23 | 刘宗银 | Compound sugar donkey-hide gelatin scarlet oral liquid and preparation method thereof |
| CN103535823B (en) * | 2013-09-27 | 2015-11-18 | 刘宗银 | A kind of compound sugar donkey-hide gelatin scarlet health drink and preparation method thereof |
| CN104799277A (en) * | 2015-03-31 | 2015-07-29 | 山东福胶集团东阿镇阿胶有限公司 | Chewable colla corii asini tablet and preparation method thereof |
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Open date: 20080227 |