CN101268836B - Nutrition high calcium medicinal granule and preparing technique - Google Patents
Nutrition high calcium medicinal granule and preparing technique Download PDFInfo
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Abstract
The invention aims to provide a nutritious high calcium medicinal granule and the production and manufacturing technology thereof. The nutritious high calcium medicinal granule includes zymohydrolysis bone powder, tuckahoe extractive, milk sugar, milk protein, oligose, casein phosphoric acid peptide, cacao powder, sweetening agent, vitamin and mineral composition. The medicinal granule obviously improves the absorptivity of calcium compared with the like product, is suitable for being taken by people of various ages, and particularly applicable to be taken by the quinquagenarian; the production and manufacturing technology is as follows: the zymohydrolysis bone powder is fully crushed and mixed with the tuckahoe extractive, so as to fully absorb axunge and phlegm which go against to be smashed, thereby being suitable for a gas stream type super micron milling technic to obtain calcium source fine powder, the technical condition is stable, thereby being suitable for manufacturing production of scale.
Description
(1) technical field:
The present invention relates to a kind of electuary and production process thereof, particularly a kind of nutritious rich-calcium electuary and production process thereof.
(2) background technology:
Along with the aging of society, in western countries, the illness rate of osteoporosis occupies first of metabolic bone disease.The misery that the osteoporosis illness brings patient and family is self-evident.According to statistics, China has approximately at present and surpasses 100,000,000 patients with osteoporosis, expects the year two thousand fifty will be increased to 200,000,000 1 thousand ten thousand.Cause the factor of increasing people's calcium deficiency: live and work rhythm is accelerated, operating pressure is big and live irregular, the structure that is not careful in one's diet reasonably combined, calcium was taken in and was less than 600 milligrams of persons and can thinks the calcium insufficiency of intake every day, easily caused the shortage of calcium in the body; Some a middle-aged person's work strains lack self health consciousness, think little of outdoor activity, and proper interior synthetic vitamin D is reduced, and influence the absorption and the utilization of calcium; Nutrition is taken in unbalanced or is lacked the necessary nutrient of human body.
The fineness in calcium source influences the absorption of human body to calcium to a great extent, and the calcium source of superfine powder can increase calcareous specific area, promotes calcareous absorption, can obtain better effect with less taking dose.Superfine communication technique is an international new developing technology over nearly 20 years.So-called ultramicro grinding is meant that utilizing machinery or hydrokinetic method to overcome solid interior cohesiveness makes it broken.Be widely used in Chinese medicine and food processing field in recent years.Ox bone because of fat, protein content is high, when using micronizer to pulverize, difficult feed, crush efficiency are low, and it is still bigger to pulverize the back particle, fineness is about 300 orders, so present stage still can not successfully be applied to superfine communication technique to pulverize ox bone.
At modern's tense working and rhythm of life, be badly in need of a class calcium source green safety, scientific formulation is reasonable, bioavilability is high,, nutrition omnibearing replenish the calcium product little to GI irritation.
(3) summary of the invention:
The object of the present invention is to provide a kind of nutritious rich-calcium electuary and production process thereof; described nutritious rich-calcium electuary calcium absorptivity obviously improves than like product; being fit to each age level people takes; being particularly useful for the elderly takes; its production process is pulverized the enzymolysis bovine bone powder, mix through abundant with tuckahoe extracts; wherein be unfavorable for grease and the mucilaginous substance pulverized with abundant absorption; make it go for air-flowing type ultramicro grinding technology and obtain calcium source fine powder; used stable process conditions is fit to large-scale industrial production.
Technical scheme of the present invention: a kind of nutritious rich-calcium electuary, it is characterized in that comprising: enzymolysis bovine bone powder, tuckahoe extracts, lactose, lactoprotein, compound sugar, CPP, cocoa power, sweetener, vitamin and mineral matter, its weight quota is than being enzymolysis bovine bone powder 18～25.2: tuckahoe extracts 2.0-2.8: lactose 20～25: lactoprotein 8～12: compound sugar 30～42: CPP 4～6: cocoa power 1.8～2.2: sweetener 0.3～0.5: vitamin 0.7～0.9: mineral matter 0.7～0.9.
Above-mentioned a kind of nutritious rich-calcium electuary is characterized in that vitamin comprises a kind of or its combination among VA, VB1, VB2, VB6, VC, the VD.
Above-mentioned a kind of nutritious rich-calcium electuary is characterized in that vitamin comprises a kind of or its combination among VC and the VD.
Above-mentioned a kind of nutritious rich-calcium electuary is characterized in that mineral matter comprises a kind of or its combination in zinc, manganese, the magnesium.
Above-mentioned a kind of nutritious rich-calcium electuary is characterized in that mineral matter comprises a kind of or its combination in zinc and the manganese.
The production process of above-mentioned nutritious rich-calcium electuary is characterized in that may further comprise the steps:
(1) uses Universalpulverizer that tuckahoe extracts is ground into fine powder, cross the 60-100 eye mesh screen; Tuckahoe extracts fine powder, enzymolysis bovine bone powder are put in the trough type mixing machine, mixed 20-30 minute; Use Universalpulverizer to pulverize once in this mixture, wherein be unfavorable for grease and the mucilaginous substance pulverized not making it to adhere to micronizer inwall and pipeline with abundant absorption; Place micronizer to pulverize in the mixture after the above-mentioned pulverizing, compressed air pressure is adjusted into 10 MPas, obtains the fine powder of fineness 3000-3500 order, granularity 5-4.5 μ m;
(2) the gained fine powder is crossed 60 eye mesh screens with lactose, lactoprotein, compound sugar, CPP, cocoa power, sweetener, vitamin and mineral matter mixing more according to the above ratio after 40-50 minute;
(3) screenings is packed with powder packets installation, per minute 35-45 bag, and every bag of 10g, 10 packedly go into 1 box, 80 box-packed production process of going into 1 case.
Beneficial effect is analyzed:
One, the enzymolysis bovine bone powder after the ultramicro grinding
1, the beneficial effect analysis of enzymolysis bovine bone powder
The primary raw material of A, enzymolysis bovine bone powder---ox bone is nutritious, and very high calcareous content is arranged, and can satisfy human body to calcareous daily demand; Its protein exceeds milk powder 23%, is the twice of pork; Contain the synthetic indispensable element of sclerotin such as abundant phosphorus, magnesium, zinc, copper, iron simultaneously.This compound bio is calcareous more to help absorbing and bony remodeling of calcium;
B, enzymolysis bovine bone powder are rich in collagen, collagen is skin, bone, tendon, the cartilage of human body, the constituent material of blood vessel, organic 70%-80% is a collagen in the bone, when bone generates, at first must synthesize the framework that sufficient collagen fabric is formed bone;
The primary raw material of C, enzymolysis bovine bone powder---ox bone derives from animal, with human body affinity height, and side effects such as edible no gastrointestinal irritation;
D, calcium phosphorus ration suit.Scientific research proves that the imbalance of dietary calcium phosphorus ratio will influence the absorption and the utilization of calcium.Particularly the shortage of phosphorus can cause bone calcium to be lost, and causes that bone calcium reduces.Calcium phosphorus ration is 2: 1 in the enzymolysis bovine bone powder, and ratio is suitable, can promote calcareous storage in vivo to stay, and promotes bone health.
2, the beneficial effect analysis of ultramicro grinding
A, enhancing bioavilability
The enzymolysis bovine bone powder is after ultramicro grinding, and fineness reaches 5-4.5 μ m, enter stomach after, active ingredient can be discharged rapidly, soluble component dissolves under the effect of gastric juice, enters the composition that dissolves behind the small intestine and begins to be absorbed; And these ultra-fine ions are because of the influence of adhesive force, and easily attached on the intestines wall, it is longer to excrete the required time, has improved the absorptivity of its insoluble composition.The fineness that improves material has promptly strengthened its skin effect, bulk effect, quantum effect and macroscopical tunnel-effect etc., be beneficial to by stomach and directly absorb, significantly increased absorptivity, significantly increase bioavilability simultaneously, enzymolysis bone calcium powder after the ultramicro grinding, the content of the absorptivity of its calcium, the residual rate of calcium, bone mineral content content, bone mineral content density and calcium all is significantly higher than common bone meal, and the absorption of calcium is directly proportional with the skeletal grain size in the bone meal.
B, give the mouthfeel of enzymolysis bovine bone powder exquisiteness
Whether product has fine and smooth lubricious mouthfeel characteristic is caused by multiple factor, but the factor that plays a decisive role is the granularity of enzymolysis bovine bone powder.Test shows, the average grain diameter of enzymolysis bovine bone powder about 25um and wherein most of grain diameter between 15～20um, product has just had fine and smooth lubricious mouthfeel characteristic; When average grain diameter surpassed 40um, product was just obviously felt harsh feeling, the also just obvious variation of aesthetic quality.
Two, the beneficial effect analysis of lactose:
Lactose promotes calcareous absorption: lactose can with the calcium chelating, form the low molecular weight soluble complex compound; Lactose can be produced acid by enteron aisle bacterium decomposing and fermenting, and the enteron aisle pH value is reduced, and this two aspect all can promote the absorption of calcium, so lactose can increase the speed that small intestine absorbs calcium.
Three, the beneficial effect analysis of lactoprotein:
Lactoprotein promotes calcareous absorption: an amount of protein can promote calcium to absorb, because lactoprotein is degraded in intestines and stomach, its catabolite such as lysine, tryptophan, arginine etc. can form soluble calcium salt with calcium, thereby increases the absorption of calcium.
Four, the beneficial effect analysis of compound sugar:
1, promote calcareous absorption: compound sugar can promote the fast breeding of Bifidobacterium in the enteron aisle, bifidobacterium fermentation lactose and mineral matters such as calcium in the lactic acid solubilized enteron aisle that produces, magnesium, iron promote the absorption of human body to these mineral matters.Discover that the mechanism that the absorption compound sugar promotes calcium to absorb mainly is by reducing enteron aisle pH value, promote the dissolving of slightly solubility calcium salt and pass through to increase intestinal epithelial cell quantity, enlarging the absorption area of calcium, and then promote the calcareous absorption of human body;
2, compound sugar can promote intestinal beneficial bacterium propagation, suppresses the spoilage organisms growth, regulates functions of intestines and stomach, keeps intestinal health, anti-treating constipation.
Five, the beneficial effect analysis of CPP:
CPP can obviously promote the absorption of calcium: CPP is owing to the compatibility to bivalent metal ion, can form soluble complexes at this weakly alkaline environment of small intestine with calcium, the commutative combination of this moderate strength can prevent the formation of calcium phosphate precipitation effectively and increase the concentration of solubility calcium, do not hinder the exchange with intestinal mucosa again, thereby promote the absorption of calcium in the intestines.Simultaneously, because the CPP molecule has the electric charge of high concentration, make them can resist the further hydrolysis of digestive ferment in the intestines, this character becomes it and guarantees in the prerequisite that enteron aisle plays a role.
Six, the beneficial effect analysis of vitamin:
1, vitamin D
A, promote the absorption of enteron aisle to calcium, phosphorus
The original point of vitamin D effect is the brush border surface at enterocyte, and calcium is entered in the cell in enteric cavity.In addition 1,25-(OH) 2D3 can with the special receptors bind in the intestinal mucosa cells, promote the synthetic calbindin of intestinal epithelial cell, the calcium ion in the enteric cavity is had stronger affinity, favourable to calcium by the running of intestinal mucosa.Vitamin D also can excite the transport process of enteron aisle to phosphorus, and this transhipment is independently, does not influence each other with the transhipment of calcium.
B, to the mobilization of skeletal calcium
Collaborative with parathyroid gland, vitamin D makes immature osteoclast precursor, changes ripe osteoclast into, promotes bone absorption; Make the bone salts dissolving in the old bone, calcium, phosphorus transporter are in blood, to improve the concentration of blood calcium and serium inorganic phosphorus; Stimulating osteoblast promotes the ripe and bone salts calmness of osteoid tissue on the other hand.
C, promotion kidney heavily absorb calcium, phosphorus
1,25-(OH) 2D3 can promote the heavily absorption of kidney convoluted tubule to calcium, phosphorus, to improve the concentration of blood calcium, serium inorganic phosphorus.
Osteocyte is presented multiple effect
2, vitamin C
A, promote calcareous absorption: vitamin C is by reducing enteron aisle pH value, the dissolving of promotion slightly solubility calcium salt, thus improve calcareous absorptivity;
B, vitamin C participate in the multiple important biosynthetic process of albumen as the confactor of enzyme, comprise the synthetic of collagen, to form the important matrix of cartilage, sclerotin, enamel and blood vessel epithelium;
C, promotion proline change the reaction of hydrogen proline into, and the hydrogen proline is one of formation collagen important component, so vitamin C can promote the generation of collagen.Thereby it is normal to keep connective tissue;
D, enhancement wound healing and increase are to being injured the esthesis that infects equal pressure.
3, vitamin A
A, vitamin A play an important role to the maturation and the integrality of bone, are the essential compositions that osteocyte is ripe and break up, and participate in bone development and the integrality of keeping epithelial tissue;
B, promotion normal development of skeleton are maintained in the balance between osteocyte and the osteoclast;
C, keep epithelial normal growth and differentiation;
D, safeguard visual performance.
4, vitamin B1
A, vitamin B1 participate in the metabolic process of body carbohydrate, play crucial effects for body provides energy;
B, vitamin B1 are kept the normal function of nerve, heart and digestive system.
5, vitamin B2
The metabolism of A, participation carbohydrate, protein, nucleic acid and fat can improve the utilization rate of human body to protein, promotes to grow;
The growth metabolism of B, participation cell is the necessary nutrient of injected organism tissue metabolism and reparation;
The function of C, protection skin follicle mucous membrane and sebaceous glands.
6, vitamin B6
A, vitamin B6 mainly participate in nearly hundred kinds of enzyme reactions with the form of phosphopyridoxal pyridoxal phosphate.Most relevant with amino acid metabolism;
B, vitamin B6 have good effect to strengthening immunity.
Seven, the beneficial effect analysis of mineral matter:
1, magnesium
A, magnesium participate in the formation of bone and tooth.The magnesium of human body 60% is present in the bone tissue;
B, magnesium can activate the effect of various enzymes to the bone metabolism, and the secretion of thyroid hormone, calcitonin and activated vitamin D metabolin is regulated in participation, in growing, skeletal growth plays the indirect adjustments and controls effect, modal bone premature aging, osteoporosis, the soft tissue calciffication of showing as of magnesium deficiency;
The anabolism of C, participation protein.
2, zinc
Aspect zinc and skeleton development, have to studies have shown that much zinc is absolutely necessary in keeping the normal bone metabolism, if zinc deficiency bone translation exception, sclerotin can take place reduces and osteoporosis, to replenish and contain zinc preparation, these situations can improve.
Zinc plays a role in bone growth and development by bone alkaline phosphatase (ALP).Bone ALP is typical zinc enzyme, be to contain one of the abundantest enzyme of zinc, and zinc concentrates on the position, activated centre of ALP enzyme, and whether the content of zinc is sufficient among the bone ALP, can directly influence the function of enzyme.Scientific research proves that in the environment of sufficient zinc was arranged, the bone tissue that is growing contained very high ALP level, and skeletal mineralization rate obviously improves simultaneously; In scarce zinc environment, the ALP in the bone tissue not only content can reduce, and activity also obviously reduces, and the growth of bone and the speed of calcification also can obviously slow down, and cause dysostosis.The expression of bone ALP is also relevant with zinc.During zinc deficiency, rna polymerase activity reduces, and causes bone ALP genetic transcription effect to weaken, and makes the synthetic minimizing of bone ALP.
The first step of bone calcification process is a Gegenbaur's cell picked-up ionized calcium, absorbs the phosphate radical of equivalent simultaneously, and both are changed in the organelle (mainly at mitochondria) by a certain percentage, synthetic calcium phosphate under the effect of ALP; Afterwards, calcium phosphate synthetic in the Gegenbaur's cell is secreted born of the same parents, enters bone matrix, with the free phosphoric acid calcium form or be deposited on the hydroxyapatite form in the space of collagenous fiber, and the process of Here it is bone calcification.From the bone calcification process as can be seen, calcium only provides the raw material of bone mineralising, and whether bone can normally carry out calcification then is that function of osteoblast determines.Break up under the situation of normal and calcium source abundance in the Gegenbaur's cell increment, the level of zinc is determining the aggregate velocity of calcium phosphate in the Gegenbaur's cell, and zinc deficiency will make osteoblastic active decline, and then influence the deposition of calcium in bone.
3, manganese
Gegenbaur's cell and osteoclast are arranged in the bone, and the both opposite restriction or checking relation in five elements of both physiological functions is complemented each other again, keeps the metabolism of bone jointly.But when in the body during manganese deficiency, the activity of osteoclast just strengthens, and the activity of Gegenbaur's cell is suppressed, and growth rate slows down, and causes into bone disorders.Original dynamic equilibrium of setting up is in vivo destroyed, and in the course of time, just can make sclerotin become loose, so the quantity not sufficient that contains of manganese also is to lead one of loose factor of matter in the body.Clinical research shows that the content of manganese only is normal person's 1/4 in the patients with osteoporosis body.
Manganese participates in the metabolism of plurality of enzymes in the body, and bone neutral and alkali phosphatase is had activation, and the synthetic enzyme system of participating in activation chondroitin sulfate, and the effect that promotes that sclerotin is synthetic is arranged.
Below by clinical testing data, further specify beneficial effect of the present invention:
Clinical data:
1 object of observation: filter out 85 routine person in middle and old age's sufferers of osteoporosis face through the detection of dual intensity X line borne densitometers.The osteoporotic diagnostic criteria of Chinese that diagnostic criteria adopts Chinese Gerontological Society to formulate in 1999, the 1～2SD that promptly reduces bone amount peak value reduces for the bone amount, and reduction 2SD is an osteoporosis.41 examples are organized in treatment, the male sex's 15 examples, women's 26 examples.Age reckling 38 years old, maximum 68 years old, average 57.4 years old, bone amount minimizing person 15 examples wherein, slight osteoporosis person's 26 examples; Control group 44 examples, minimum 42 years old of age, maximum 65 years old, average 55.8 years old, bone amount minimizing person 17 examples wherein, slight osteoporosis person's 27 examples.More than two groups of personnel all get rid of the various acute and chronic diseases that diabetes, hyperthyroidism, kidney trouble etc. influence the bone metabolism.
2 measuring instruments and method: the Osteocore dual intensity X line borne densitometers (DEXA) that adopts French Medilink company to produce carries out the bone density measurement of lumbar vertebrae (L2, L3, L4) and hip (neck of femur, Ward ' s district, greater trochanter) respectively to two groups of personnel before and after treatment.Oral above-mentioned nutritious rich-calcium electuary is organized in treatment, every day 2 times, each 1 bag, took continuously 6 months, and many foods contains calcium diet, suitably increases amount of exercise and solar radiation; Control group is not obeyed any calcium agent, only advises its many foods to contain calcium diet, suitably increase amount of exercise and solar radiation.All after half a year, check bone density for two groups.
3 results
Lumbar vertebrae (L before and after the treatment of treatment group
2, L
3, L
4) and hip (neck of femur, Ward ' s district, greater trochanter) BMD contrast
Lumbar vertebrae and bmd of proximal femur compare (g/cm before and after table 1 patient treatment
2)
| The position | n | Before the treatment | After the treatment |
| L 2 | 41 | 0.672±0.065 | 0.698±0.074 |
| L 3 | 41 | 0.678±0.115 | 0.715±0.102 |
| L 4 | 41 | 0.672±0.065 | 0.701±0.076 |
| Neck of femur | 41 | 0.633±0.067 | 0.667±0.063 |
| Ward ' s district | 41 | 0.437±0.085 | 0.465±0.099 |
| Greater trochanter | 41 | 0.585±0.085 | 0.612±0.083 |
Annotate: with comparison P＜0.05 before the medication
More than each position increased by 3.8%, 5.4%, 4.3%, 5.3%, 6.4%, 4.6% respectively according to its BMD of order such as L2, L3, L4, neck of femur, Ward ' s district, greater trochanters.Lumbar vertebrae BMD on average increases by 4.5%, and bmd of proximal femur on average increases by 5.4%.Other positions are relatively preceding with treatment except that greater trochanter, and difference all has conspicuousness (P＜0.05).And do not find any bad reaction.Recent 80% patient phenomenons such as pain in waist and lower extremities, systremma in the time in 1～2 week of taking medicine alleviate or disappear.
3.2 control group lumbar vertebrae and bmd of proximal femur are relatively
Table 2 control group lumbar vertebrae and bmd of proximal femur are relatively
| The position | n | Before the treatment | After the treatment |
| L 2 | 44 | 0.681±0.051 | 0.680±0.058 |
| L 3 | 44 | 0.686±0.104 | 0.688±0.114 |
| L 4 | 44 | 0.695±0.089 | 0.675±0.091 |
| Neck of femur | 44 | 0.699±0.045 | 0.702±0.056 |
| Ward ' s district | 44 | 0.486±0.097 | 0.479±0.089 |
| Greater trochanter | 44 | 0.601±0.079 | 0.589±0.091 |
Annotate: with relatively P is all＞0.05 before the medication
Each position BMD is changed to L
2Reduce 0.1%, L3 increases by 0.29%, L
4Reduce 2.8%, neck of femur increases by 0.4%, and Ward ' s district reduces 1.4%, and greater trochanter reduces 1.9%.Lumbar vertebrae BMD decreased average 0.03%, near end of thighbone BMD decreased average 0.96%.Symptoms such as patient's pain in waist and lower extremities, systremma do not have obvious improvement.
In sum, the present invention explores through repetition test, and each composition ratio collocation is scientific and reasonable in the prescription, each nutrition complements each other, and the enzymolysis bovine bone powder ox bone of ultramicro grinding is nutritious, the calcium content height, be rich in collagen, and calcium phosphorus ration is suitable, takes the no GI irritation in back; The enzymolysis ox bone is through after the ultramicro grinding, its fineness reaches 3000-3500 order, granularity 5-4.5 μ m, through after the ultramicro grinding, enzymolysis ox bone particulate specific area enlarges markedly, increase with the enteron aisle contact area, and easily, excrete required time lengthening, can obviously improve the absorptivity of calcium attached on the intestines wall; The compound sugar that adds can promote the fast breeding of Bifidobacterium in the enteron aisle; Lactose can be as the substrate of bifidobacterium fermentation, bifidobacterium fermentation lactose and mineral matters such as calcium in the lactic acid solubilized enteron aisle that produces, magnesium, iron, promote the absorption of human body to these mineral matters, simultaneously lactose can with the calcium chelating, form the low molecular weight soluble complex compound, therefore lactose and compound sugar are promoting to have brought into play synergistic function aspect the calcium absorption, and calcium supplementing effect is remarkable; The lactoprotein, CPP, vitamin and the mineral matter that add both can promote calcareous absorption, had the effect of keeping the bone eubolism, promoting bone health again, increased bone density, prevention of osteoporosis from two aspects; Its production process is pulverized the enzymolysis bovine bone powder, mix through abundant with tuckahoe extracts; wherein be unfavorable for grease and the mucilaginous substance pulverized with abundant absorption; make it go for air-flowing type ultramicro grinding technology; obtain the calcium source fine powder of fineness 3000-3500 order, granularity 5-4.5 μ m; fully mix with other raw material again; used stable process conditions is fit to large-scale industrial production.
Eating effect case of the present invention:
1, Tang * *, the man, 71 years old, retired associate professor, for many years the back of the body, waist, having a dull ache is difficult to stand, long-term treatment is invalid, is short of physical strength, tired, reading headache looks wane and sallow.Measure lumbar vertebrae L
2-4Side position BMD is 0.65g/cm
2, fl neck BMD is 0.50g/cm
2, be the senile osteoporosis patient.Through taking described nutritious rich-calcium electuary, every day 800mg, whole body bone continues edible half a year not bitterly after two months, every days 2 gram, health is clearly better, muscle power heightens, and braces up, reading revises the draft far into the night, also not bitterly, spirit is also fine head.Measure lumbar vertebrae L once more to hospital
2-4Side position BMD is 0.86g/cm
2, fl neck BMD is 0.71g/cm
2After continue again to take.
2, Feng * *, the woman, 61 years old, suffer from multiple disease, wherein the most very the person has a pain in the back, numb limb, even both feet almost lose consciousness, it is very difficult to stand and walk.Measure lumbar vertebrae L
2-4Side position BMD is 0.71g/cm
2, fl neck BMD is 0.58g/cm
2, be patients with osteoporosis.Through edible described nutritious rich-calcium electuary, every day 800mg, just obviously take effect after one month, both feet become numbness by imperception almost consciousness, continues edible, numbness becomes pain, above-mentioned symptom all disappears after 1 year, and can push away the grandson with dolly and play everywhere, walks, goes shopping, go going window-shopping of several inside and outsides alone inside the city, measure lumbar vertebrae L once more
2-4Side position BMD is 1.03g/cm
2, fl neck BMD is 0.80g/cm
2
3, cover * *, the man, 47 years old, lumbocrural pain was existing more than 1 year, recently more very, also can tumble on foot sometimes.Take described nutritious rich-calcium electuary upon somebody's introduction, every day 600mg, after three months, lumbocrural pain alleviates, sensation has been walked also energetically.After continue again to take.
4, Wu *, the man, 52 years old, the surgeon often will be for the patient performs an operation, but occur swivel of hand pain before 3 years, there is metaboly in left hand the five fingers joint, by bone densitometry, is shown as slight osteoporosis.Since beginning to take described nutritious rich-calcium electuary, every day 800mg, take one month after, ten refer to stretch freely, again do not have uncomfortable sensation, and I feel that energy is more abundant now.
5, old * *, man, 65 years old, retired veteran cadre.Normal sense lumbago, whole body pain all over the joints 2 years half, the work fatiguability of learning at ordinary times or do chores.Take the photograph sheet through X-ray and be diagnosed as senile osteoporosis.Through taking described nutritious rich-calcium electuary, symptom obviously alleviates, and after continuing to take 2 months, symptom all disappears before, and is energetic, and appetite increases.The back requires to continue to take.
6, open *, man, 55 years old, workman.Normal sense lumbocrural pain, weakness of limbs, the legs and feet idol has the cramp symptom.Take described nutritious rich-calcium electuary upon somebody's introduction, every day 600mg, after 2 months, conscious lumbocrural pain sx, after continuing to take 4 months, the cramp transference cure, the state of mind is clearly better.The back requires to continue to take.
7, Jiang * *, woman, 54 years old, peasant.Normal sense lumbocrural pain, dysstasia after the sitting, and shank is often numb, and it is bad to sleep.Through taking described nutritious rich-calcium electuary, every day 600mg, after 2 months, lumbocrural pain alleviates, and stands after the sitting easily, the shank pain and numbness alleviates, after continue again to take.
8, Lee * *, the woman, 51 years old, often cry have a pain in the back, weak on his pins, provoke with words always, pinch and beat just more easily, doctor's calcium deficiency of all saying so, we have successively taken good polycalcium agent.Effect is all not obvious, has hindered brains for this reason.After take described nutritious rich-calcium electuary upon somebody's introduction, 800mg takes after two months every day, pain relief continues to take, after 1 year, waist is not sour, the back of the body not bitterly, legs and feet are also strong.
Superiority of the present invention: (1) the present invention adopts the enzymolysis bovine bone powder of ultramicro grinding, and ox bone is nutritious, and the calcium content height is rich in collagen, and calcium phosphorus ration is suitable, takes the no GI irritation in back; The enzymolysis ox bone is through after the ultramicro grinding, and enzymolysis ox bone particulate specific area enlarges markedly, and increases with the enteron aisle contact area, and easily attached on the intestines wall, excretes required time lengthening, makes calcium absorptivity obviously improve than other product of replenishing the calcium; (2) add lactose and compound sugar in prescription, the two is promoting can to bring into play synergistic function aspect the calcium absorption, and calcium supplementing effect is remarkable; (3) in prescription, add lactoprotein, CPP, vitamin and mineral matter, both can promote calcareous absorption, have the effect of keeping the bone eubolism, promoting bone health again, increase bone density from two aspects, prevention of osteoporosis is particularly suitable for the elderly and takes; (4) its production process is pulverized the enzymolysis bovine bone powder, mix through abundant with tuckahoe extracts; wherein be unfavorable for grease and the mucilaginous substance pulverized with abundant absorption; make it go for air-flowing type ultramicro grinding technology; obtain the calcium source fine powder of fineness 3000-3500 order, granularity 5-4.5 μ m; fully mix with other raw material again; used stable process conditions is fit to large-scale industrial production.
(4) specific embodiment:
Embodiment 1: a kind of nutritious rich-calcium electuary, it is characterized in that comprising enzymolysis bovine bone powder, tuckahoe extracts, lactose, lactoprotein, compound sugar, CPP, cocoa power, sweetener, vitamin C and mineral matter zinc, its weight quota is than being enzymolysis bovine bone powder 18: tuckahoe extracts 2: lactose 25: lactoprotein 12: compound sugar 30: CPP 6: cocoa power 1.8: sweetener 0.5: vitamin C 0.7: mineral matter zinc 0.9.
The production process of above-mentioned nutritious rich-calcium electuary is characterized in that may further comprise the steps:
(1) uses Universalpulverizer that tuckahoe extracts is ground into fine powder, cross 100 eye mesh screens; Tuckahoe extracts fine powder, enzymolysis bovine bone powder are put in the trough type mixing machine, mixed 30 minutes; Use Universalpulverizer to pulverize once in this mixture, wherein be unfavorable for grease and the mucilaginous substance pulverized not making it to adhere to micronizer inwall and pipeline with abundant absorption; Place micronizer to pulverize in the mixture after the above-mentioned pulverizing, compressed air pressure is adjusted into 10 MPas, obtains the fine powder of fineness 3500 orders, granularity 4.5 μ m;
(2) the gained fine powder mixes mistake 60 eye mesh screens after 40 minutes more according to the above ratio with lactose, lactoprotein, compound sugar, CPP, cocoa power, sweetener, vitamin C and mineral matter zinc;
(3) screenings is packed with powder packets installation, 35 bags of per minutes, and every bag of 10g, 10 packedly go into 1 box, 80 box-packed production process of going into 1 case.
Embodiment 2: a kind of nutritious rich-calcium electuary, it is characterized in that comprising enzymolysis bovine bone powder, tuckahoe extracts, lactose, lactoprotein, compound sugar, CPP, cocoa power, sweetener, vitamin D and mineral matter manganese, its weight quota is than being enzymolysis bovine bone powder 25.2: tuckahoe extracts 2.8: lactose 20: lactoprotein 8: compound sugar 42: CPP 4: cocoa power 2.2: sweetener 0.3: vitamin D 0.9: mineral matter manganese 0.7.
The production process of above-mentioned nutritious rich-calcium electuary is characterized in that may further comprise the steps:
(1) uses Universalpulverizer that tuckahoe extracts is ground into fine powder, cross 60 eye mesh screens; Tuckahoe extracts fine powder, enzymolysis bovine bone powder are put in the trough type mixing machine, mixed 20 minutes; Use Universalpulverizer to pulverize once in this mixture, wherein be unfavorable for grease and the mucilaginous substance pulverized not making it to adhere to micronizer inwall and pipeline with abundant absorption; Place micronizer to pulverize in the mixture after the above-mentioned pulverizing, compressed air pressure is adjusted into 10 MPas, obtains the fine powder of fineness 3000 orders, granularity 5 μ m;
(2) the gained fine powder mixes mistake 60 eye mesh screens after 50 minutes more according to the above ratio with lactose, lactoprotein, compound sugar, CPP, cocoa power, sweetener, vitamin D and mineral matter manganese;
(3) screenings is packed with powder packets installation, 45 bags of per minutes, and every bag of 10g, 10 packedly go into 1 box, 80 box-packed production process of going into 1 case.
Embodiment 3: a kind of nutritious rich-calcium electuary, it is characterized in that comprising: enzymolysis bovine bone powder, tuckahoe extracts, lactose, lactoprotein, compound sugar, CPP, cocoa power, sweetener, vitamin C, vitamin D, mineral matter zinc, mineral matter manganese, its weight quota is than being enzymolysis bovine bone powder 22: tuckahoe extracts 2.4: lactose 23: lactoprotein 10: compound sugar 36: CPP 5: cocoa power 2.0: sweetener 0.4: vitamin C 0.4: vitamin D 0.4: mineral matter zinc 0.4: mineral matter manganese 0.4.
The production process of above-mentioned nutritious rich-calcium electuary is characterized in that may further comprise the steps:
(1) uses Universalpulverizer that tuckahoe extracts is ground into fine powder, cross 80 eye mesh screens; Tuckahoe extracts fine powder, enzymolysis bovine bone powder are put in the trough type mixing machine, mixed 25 minutes; Use Universalpulverizer to pulverize once in this mixture, wherein be unfavorable for grease and the mucilaginous substance pulverized not making it to adhere to micronizer inwall and pipeline with abundant absorption; Place micronizer to pulverize in the mixture after the above-mentioned pulverizing, compressed air pressure is adjusted into 10 MPas, obtains the fine powder of fineness 3300 orders, granularity 4.8 μ m;
(2) the gained fine powder mixes mistake 60 eye mesh screens after 45 minutes more according to the above ratio with lactose, lactoprotein, compound sugar, CPP, cocoa power, sweetener, vitamin C, vitamin D, mineral matter zinc, mineral matter manganese;
(3) screenings is packed with powder packets installation, 40 bags of per minutes, and every bag of 10g, 10 packedly go into 1 box, 80 box-packed production process of going into 1 case.
Embodiment 4: a kind of nutritious rich-calcium electuary, it is characterized in that comprising the enzymolysis bovine bone powder, tuckahoe extracts, lactose, lactoprotein, compound sugar, CPP, cocoa power, sweetener, vitamin V A, VB1, VB2, VB6, VC, VD and mineral matter zinc, manganese, magnesium, its weight quota is than being enzymolysis bovine bone powder 21.6: tuckahoe extracts 2.4: lactose 21: lactoprotein 10: compound sugar 36: CPP 5: cocoa power 2.0: sweetener 0.4: vitamin V A 0.1: VB10.1: VB20.1: VB60.1: VC 0.2: VD 0.2: mineral matter zinc 0.3: manganese 0.3: magnesium 0.2.
The production process of above-mentioned nutritious rich-calcium electuary is characterized in that may further comprise the steps:
(1) uses Universalpulverizer that tuckahoe extracts is ground into fine powder, cross 80 eye mesh screens; Tuckahoe extracts fine powder, enzymolysis bovine bone powder are put in the trough type mixing machine, mixed 25 minutes; Use Universalpulverizer to pulverize once in this mixture, wherein be unfavorable for grease and the mucilaginous substance pulverized not making it to adhere to micronizer inwall and pipeline with abundant absorption; Place micronizer to pulverize in the mixture after the above-mentioned pulverizing, compressed air pressure is adjusted into 10 MPas, obtains the fine powder of fineness 3300 orders, granularity 4.8 μ m;
(2) the gained fine powder mixes mistake 60 eye mesh screens after 45 minutes more according to the above ratio with lactose, lactoprotein, compound sugar, CPP, cocoa power, sweetener, vitamin V A, VB1, VB2, VB6, VC, VD and mineral matter zinc, manganese, magnesium;
(3) screenings is packed with powder packets installation, 40 bags of per minutes, and every bag of 10g, 10 packedly go into 1 box, 80 box-packed production process of going into 1 case.
Claims (10)
1. nutritious rich-calcium electuary, it is characterized in that being made up of enzymolysis bovine bone powder, tuckahoe extracts, lactose, lactoprotein, compound sugar, CPP, cocoa power, sweetener, vitamin and mineral matter, its weight quota is than being enzymolysis bovine bone powder 18～25.2: tuckahoe extracts 2.0-2.8: lactose 20～25: lactoprotein 8～12: compound sugar 30～42: CPP 4～6: cocoa power 1.8～2.2: sweetener 0.3～0.5: vitamin 0.7～0.9: mineral matter 0.7～0.9.
2. a kind of nutritious rich-calcium electuary according to claim 1 is characterized in that vitamin comprises a kind of or its combination among VA, VB1, VB2, VB6, VC, the VD.
3. a kind of nutritious rich-calcium electuary according to claim 1 and 2 is characterized in that vitamin comprises a kind of or its combination among VC and the VD.
4. a kind of nutritious rich-calcium electuary according to claim 1 is characterized in that mineral matter comprises a kind of or its combination in zinc, manganese, the magnesium.
5. according to claim 1 or 4 described a kind of nutritious rich-calcium electuaries, it is characterized in that mineral matter comprises a kind of or its combination in zinc and the manganese.
6. a kind of nutritious rich-calcium electuary according to claim 1, it is characterized in that comprising enzymolysis bovine bone powder, tuckahoe extracts, lactose, lactoprotein, compound sugar, CPP, cocoa power, sweetener, vitamin C and mineral matter zinc, its weight quota is than being enzymolysis bovine bone powder 18: tuckahoe extracts 2: lactose 25: lactoprotein 12: compound sugar 30: CPP 6: cocoa power 1.8: sweetener 0.5: vitamin C 0.7: mineral matter zinc 0.9.
7. a kind of nutritious rich-calcium electuary according to claim 1, it is characterized in that comprising enzymolysis bovine bone powder, tuckahoe extracts, lactose, lactoprotein, compound sugar, CPP, cocoa power, sweetener, vitamin D and mineral matter manganese, its weight quota is than being enzymolysis bovine bone powder 25.2: tuckahoe extracts 2.8: lactose 20: lactoprotein 8: compound sugar 42: CPP 4: cocoa power 2.2: sweetener 0.3: vitamin D 0.9: mineral matter manganese 0.7.
8. a kind of nutritious rich-calcium electuary according to claim 1, it is characterized in that comprising: enzymolysis bovine bone powder, tuckahoe extracts, lactose, lactoprotein, compound sugar, CPP, cocoa power, sweetener, vitamin C, vitamin D, mineral matter zinc, mineral matter manganese, its weight quota is than being enzymolysis bovine bone powder 22: tuckahoe extracts 2.4: lactose 23: lactoprotein 10: compound sugar 36: CPP 5: cocoa power 2.0: sweetener 0.4: vitamin C 0.4: vitamin D 0.4: mineral matter zinc 0.4: mineral matter manganese 0.4.
9. a kind of nutritious rich-calcium electuary according to claim 1, it is characterized in that comprising the enzymolysis bovine bone powder, tuckahoe extracts, lactose, lactoprotein, compound sugar, CPP, cocoa power, sweetener, vitamin V A, VB1, VB2, VB6, VC, VD and mineral matter zinc, manganese, magnesium, its weight quota is than being enzymolysis bovine bone powder 21.6: tuckahoe extracts 2.4: lactose 21: lactoprotein 10: compound sugar 36: CPP 5: cocoa power 2.0: sweetener 0.4: vitamin V A 0.1: VB10.1: VB20.1: VB60.1: VC 0.2: VD 0.2: mineral matter zinc 0.3: manganese 0.3: magnesium 0.2.
10. the production process of each described nutritious rich-calcium electuary of claim 1-9 is characterized in that may further comprise the steps:
(1) uses Universalpulverizer that tuckahoe extracts is ground into fine powder, cross the 60-100 eye mesh screen; Tuckahoe extracts fine powder, enzymolysis bovine bone powder are put in the trough type mixing machine, mixed 20-30 minute; Use Universalpulverizer to pulverize once in this mixture, wherein be unfavorable for grease and the mucilaginous substance pulverized not making it to adhere to micronizer inwall and pipeline with abundant absorption; Place micronizer to pulverize in the mixture after the above-mentioned pulverizing, compressed air pressure is adjusted into 10 MPas, obtains the fine powder of fineness 3000-3500 order, granularity 5-4.5 μ m;
(2) the gained fine powder is crossed 60 eye mesh screens with lactose, lactoprotein, compound sugar, CPP, cocoa power, sweetener, vitamin and mineral matter mixing more according to the above ratio after 40-50 minute;
(3) screenings is packed with powder packets installation, per minute 35-45 bag, and every bag of 10g, 10 packedly go into 1 box, 80 box-packed production process of going into 1 case.
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| CN2008100071938A CN101268836B (en) | 2007-03-23 | 2008-02-04 | Nutrition high calcium medicinal granule and preparing technique |
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| CN103211836A (en) * | 2013-04-11 | 2013-07-24 | 天津天狮生物发展有限公司 | Composition for treating osteoporosis |
| CN103583955A (en) * | 2013-11-15 | 2014-02-19 | 孟令刚 | Calcium supplementing composition |
| CN104605225A (en) * | 2015-01-02 | 2015-05-13 | 保龄宝生物股份有限公司 | Collagen powder suitable for middle-aged people and aged people |
| US20190175533A1 (en) * | 2017-12-12 | 2019-06-13 | Pharmco International Inc. | Nutritional supplement for improved calcium absorption |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1170523A (en) * | 1997-08-01 | 1998-01-21 | 天津天狮集团有限公司 | Food for supplementing calcium and strengthening kidney and its production |
| CN1176072A (en) * | 1997-08-01 | 1998-03-18 | 天津天狮集团有限公司 | High-calcium nutrient and its preparation |
| CN1205881A (en) * | 1997-07-18 | 1999-01-27 | 柳永明 | Calcium supplementing and fracture setting granule |
-
2008
- 2008-02-04 CN CN2008100071938A patent/CN101268836B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1205881A (en) * | 1997-07-18 | 1999-01-27 | 柳永明 | Calcium supplementing and fracture setting granule |
| CN1170523A (en) * | 1997-08-01 | 1998-01-21 | 天津天狮集团有限公司 | Food for supplementing calcium and strengthening kidney and its production |
| CN1176072A (en) * | 1997-08-01 | 1998-03-18 | 天津天狮集团有限公司 | High-calcium nutrient and its preparation |
Non-Patent Citations (1)
| Title |
|---|
| 高学敏等.中医预防及改善骨质疏松系列保健食品的研发思路及范例介绍.《中国骨质疏松杂志》.2006,(第04期), * |
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