CN108968075A - It is a kind of improve bone health composition and its application - Google Patents
It is a kind of improve bone health composition and its application Download PDFInfo
- Publication number
- CN108968075A CN108968075A CN201810732772.2A CN201810732772A CN108968075A CN 108968075 A CN108968075 A CN 108968075A CN 201810732772 A CN201810732772 A CN 201810732772A CN 108968075 A CN108968075 A CN 108968075A
- Authority
- CN
- China
- Prior art keywords
- parts
- powder
- bone
- composition
- calcium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 28
- 230000037180 bone health Effects 0.000 title claims abstract description 18
- 239000000843 powder Substances 0.000 claims abstract description 53
- 235000013162 Cocos nucifera Nutrition 0.000 claims abstract description 20
- 244000060011 Cocos nucifera Species 0.000 claims abstract description 19
- 241000251730 Chondrichthyes Species 0.000 claims abstract description 18
- 102000008186 Collagen Human genes 0.000 claims abstract description 18
- 108010035532 Collagen Proteins 0.000 claims abstract description 18
- 229920001436 collagen Polymers 0.000 claims abstract description 18
- 210000000845 cartilage Anatomy 0.000 claims abstract description 17
- 229910052500 inorganic mineral Inorganic materials 0.000 claims abstract description 17
- 239000011707 mineral Substances 0.000 claims abstract description 17
- 150000003839 salts Chemical class 0.000 claims abstract description 16
- 240000008067 Cucumis sativus Species 0.000 claims abstract description 15
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 claims abstract description 14
- 239000002994 raw material Substances 0.000 claims abstract description 13
- 235000013406 prebiotics Nutrition 0.000 claims description 18
- 239000011230 binding agent Substances 0.000 claims description 17
- 239000008187 granular material Substances 0.000 claims description 14
- 238000002360 preparation method Methods 0.000 claims description 9
- 239000000463 material Substances 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 239000002245 particle Substances 0.000 claims description 4
- 239000002552 dosage form Substances 0.000 claims description 2
- 239000012467 final product Substances 0.000 claims description 2
- 239000002775 capsule Substances 0.000 claims 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical group [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract description 34
- 210000000988 bone and bone Anatomy 0.000 abstract description 28
- 239000011575 calcium Substances 0.000 abstract description 26
- 229910052791 calcium Inorganic materials 0.000 abstract description 26
- 239000000047 product Substances 0.000 abstract description 20
- 208000001132 Osteoporosis Diseases 0.000 abstract description 8
- 230000037182 bone density Effects 0.000 abstract description 8
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 abstract description 6
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 abstract description 6
- 229920001287 Chondroitin sulfate Polymers 0.000 abstract description 6
- 229940059329 chondroitin sulfate Drugs 0.000 abstract description 6
- 230000036541 health Effects 0.000 abstract description 6
- 239000013589 supplement Substances 0.000 abstract description 6
- 230000003185 calcium uptake Effects 0.000 abstract description 4
- 229910000019 calcium carbonate Inorganic materials 0.000 abstract description 3
- 230000008021 deposition Effects 0.000 abstract description 3
- 230000002195 synergetic effect Effects 0.000 abstract description 2
- 239000006071 cream Substances 0.000 abstract 1
- 230000000052 comparative effect Effects 0.000 description 14
- 238000012360 testing method Methods 0.000 description 11
- 230000000694 effects Effects 0.000 description 10
- 241000700159 Rattus Species 0.000 description 9
- 210000000689 upper leg Anatomy 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 238000000034 method Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 3
- 239000008367 deionised water Substances 0.000 description 3
- 229910021641 deionized water Inorganic materials 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000013641 positive control Substances 0.000 description 3
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 description 2
- 229940078581 Bone resorption inhibitor Drugs 0.000 description 2
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 229940036811 bone meal Drugs 0.000 description 2
- 239000002374 bone meal Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 231100000673 dose–response relationship Toxicity 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940011871 estrogen Drugs 0.000 description 2
- 239000000262 estrogen Substances 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 239000004459 forage Substances 0.000 description 2
- 229960002442 glucosamine Drugs 0.000 description 2
- 235000013402 health food Nutrition 0.000 description 2
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 2
- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 description 1
- 206010003658 Atrial Fibrillation Diseases 0.000 description 1
- 229940122361 Bisphosphonate Drugs 0.000 description 1
- 208000010392 Bone Fractures Diseases 0.000 description 1
- 208000020084 Bone disease Diseases 0.000 description 1
- 241000737241 Cocos Species 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 206010017076 Fracture Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- 208000013038 Hypocalcemia Diseases 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- 206010058667 Oral toxicity Diseases 0.000 description 1
- 208000001164 Osteoporotic Fractures Diseases 0.000 description 1
- 241000700157 Rattus norvegicus Species 0.000 description 1
- 230000007059 acute toxicity Effects 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- 210000003484 anatomy Anatomy 0.000 description 1
- 230000001174 ascending effect Effects 0.000 description 1
- 238000001479 atomic absorption spectroscopy Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000002146 bilateral effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 150000004663 bisphosphonates Chemical group 0.000 description 1
- 239000007767 bonding agent Substances 0.000 description 1
- 210000002798 bone marrow cell Anatomy 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- HEBKCHPVOIAQTA-NGQZWQHPSA-N d-xylitol Chemical compound OC[C@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-NGQZWQHPSA-N 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- XQRLCLUYWUNEEH-UHFFFAOYSA-L diphosphonate(2-) Chemical compound [O-]P(=O)OP([O-])=O XQRLCLUYWUNEEH-UHFFFAOYSA-L 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 235000014103 egg white Nutrition 0.000 description 1
- 210000000969 egg white Anatomy 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000013376 functional food Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 230000000705 hypocalcaemia Effects 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- DLRVVLDZNNYCBX-RTPHMHGBSA-N isomaltose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)C(O)O1 DLRVVLDZNNYCBX-RTPHMHGBSA-N 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000036244 malformation Effects 0.000 description 1
- 210000005075 mammary gland Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 231100000150 mutagenicity / genotoxicity testing Toxicity 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 231100000418 oral toxicity Toxicity 0.000 description 1
- 230000011164 ossification Effects 0.000 description 1
- 210000000963 osteoblast Anatomy 0.000 description 1
- 210000002997 osteoclast Anatomy 0.000 description 1
- 210000004409 osteocyte Anatomy 0.000 description 1
- 208000029985 osteonecrosis of the jaw Diseases 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The present invention provide it is a kind of improve bone health composition and its application, the composition in terms of mass parts, by include following components raw material be made: 10-30 part of shark cartilage powder, 1-5 parts of collagen, 30-60 parts of coconut powder and cream 1-5 parts of mineral salt.Composition of the invention is different from the formula " chondroitin sulfate+collagen+calcium carbonate " of Traditional health care product, but being added to newborn mineral salt is calcium source, it is added to cucumber seed powder and coconut powder again, compatibility is reasonable, synergistic effect is played between each component, enable composition effectively supplement calcium, promotion calcium uptake and deposition, while improving bone weight and bone density, calcium content of bone is significantly improved to 200mg/g or more, realize the problems such as preventing and treating osteoporosis, bone health is improved, middle-aged and the old's quality of life is improved.
Description
Technical field
The present invention relates to functional food or field of health care food, more particularly, to a kind of group for improving bone health
Close object and its application.
Background technique
Osteoporosis is one kind low with bone amount, bone micro-structure destruction, the increase of bone brittleness, easily generation fracture is caused to be special
The systemic osteopathy of sign, which can betide different sexes and any age, but be more common in postmenopausal women and elderly men, and
And with age, risk increases.Show that global sufferers of osteoporosis face is more than 200,000,000 people at present according to WHO statistics, the U.S.,
West Europe and Japan reach more than 7,500 ten thousand, and China about 90,000,000, disease incidence has leapt to the 7th of the various common diseases in the world.Bone
Matter is loose high with the treatment cost and nursing expense of osteoporotic fracture, and very big psychology and life are brought to sufferers themselves and family
Pressure living, also causes serious financial burden to society.
Currently, treatment osteoporosis, mainly using bone resorption inhibitor as therapeutic agent, bone resorption inhibitor is broken by reducing
The generation (such as estrogen) of osteocyte reduces osteoclast activity (such as Diphosphonate) to inhibit the absorption of bone to prevent bone amount mistake
It is lose more.But a large amount of intakes of estrogen can include to many other tissues mammary gland, uterus, angiocarpy bring it is more serious
Side effect, therefore gradually substituted by bisphosphonates, but the long-time service of such drug also brings along side effect, example
The problems such as such as stimulating oesophagus, hypocalcemia, stimulation kidney, lower jaw osteonecrosis and atrial fibrillation.
The product for improving bone health at present is a major class in health food, very popular, market sales volume by
Year increases.Traditional health care product on the market also mainly prevent and treat osteoporosis in a manner of replenishing the calcium merely, and such as calcium, you are odd
D, new Gaizhonggai board high calcium tablet etc..But it is new studies have shown that preventing and treating osteoporosis not only wants supplement calcium, it is heavier
What is wanted is to promote calcareous absorption.
Shark cartilage powder refers to powder made of the cartilage of shark, is rich in chondroitin sulfate, protein and mucopolysaccharide, tool
Have and promotes the multiple biological activities such as osteoblast increment, bone doped calcium, induction new bone formation, protection cartilage.Since it is apparent
Bioactivity is widely used in bone health class health care product, and the most common compatibility mode is as follows: chondroitin sulfate+amino
Glucose+collagen, chondroitin sulfate+Glucosamine+composite joint tie up ossein MSM, chondroitin sulfate+Glucosamine
+ shark cartilage powder etc..
Although but the product that above-mentioned common compatibility mode obtains can have with what supplement calcium, human body really absorbed
Limit, calcium content of bone improve not significant.
Summary of the invention
In view of the problems of the existing technology, the present invention provide it is a kind of improve bone health composition and its application, this
The composition of invention has the function of good promotion calcium uptake and deposition, significantly improves bone health.
A kind of composition improving bone health provided by the invention, in terms of mass parts, by the raw material including following components
It is made: 10-30 parts of shark cartilage powder, 1-5 parts of collagen, 30-60 parts of coconut powder and newborn 1-5 parts of mineral salt.
In above-mentioned technical proposal, by by the shark cartilage powder of specific proportion, collagen, coconut powder and newborn mineral salt group
Close, play synergistic effect each other, it is more reasonable than traditional health caring product prescription, can effectively supplement calcium, promote calcium uptake and heavy
Product realizes the problems such as preventing and treating osteoporosis to improve bone weight, bone density and calcium content of bone, improves bone health.
Preferably, the composition further includes 30-60 parts of cucumber seed powder.Composition effect after cucumber seed powder is added is more
It is good.
Preferably, the composition is made: shark cartilage powder 10-20 in terms of mass parts by the raw material for including following components
Part, 1-3 parts of collagen, 30-50 parts of cucumber seed powder, 30-50 parts of coconut powder and newborn 1-4 parts of mineral salt.
Preferably, the raw material is shark cartilage powder, collagen, cucumber seed powder, coconut powder and newborn mineral salt.
The composition can be equipped with certain auxiliary material, and any dosage form applicable in practice, including granule, glue is made
Wafer, tablet and electuary etc..
It is described the present invention also provides a kind of granule for improving bone health, including any of the above-described kind of composition and auxiliary material
Auxiliary material is prebiotics and binder.
In above-mentioned technical proposal, be made granule is easy to carry, take quickly, mouthfeel it is moderate, and can effectively keep each original
Pure natural special aroma possessed by expecting.Auxiliary material selects prebiotics and binder, first is that former composition effect without negative effect,
Second is that advantageously forming particle.
Preferably, the prebiotics mass parts are 50-100 parts, and the consumption of binder is remaining component weight
2%-10%.
Preferably, the prebiotics are isomalto-oligosaccharide, oligofructose or xylo-oligosaccharide.
Preferably, the binder is the alcohol of volumetric concentration 80%.
The present invention also provides the preparation methods of above-mentioned granule, comprising: each component and prebiotics first crushed 60 respectively
Then smashed each component and prebiotics are uniformly mixed according to the proportion, add binder, be made 20~80 by~80 meshes
Purpose particle, finally drying dispense to obtain the final product.
Above-mentioned preparation method simple process, and the influence of the active constituent of each raw material component will be preferably minimized, make obtained
Product efficacy is best.
Composition of the invention is different from the formula (chondroitin sulfate+collagen+calcium carbonate) of Traditional health care product, addition
Newborn mineral salt also added cucumber seed powder and coconut powder, compatibility is reasonable, and collaboration is played between each component to replace calcium carbonate be calcium source
Effect enables composition effectively supplement calcium, promotion calcium uptake and deposition to significantly improve while improving bone weight and bone density
Calcium content of bone realizes the problems such as preventing and treating osteoporosis, improves bone health, improve the middle-aged and the old to 200mg/g or more
Quality of life.
Specific embodiment
Combined with specific embodiments below, specific embodiments of the present invention will be described in further detail.Following embodiment
For illustrating the present invention, but it is not intended to limit the scope of the invention.
In following embodiment, shark cartilage powder, collagen and newborn mineral salt used build biotechnology purchased from Tianjin benefit again
Co., Ltd；Cucumber seed powder used is the seed of cucurbitaceous plant cucumber, cleaned clean, removal impurity, drying, crushing, mistake
It sieves, sterilize, be purchased from Tianjin Yi Beijian Bioisystech Co., Ltd；Coconut powder used is pure natural coconut powder, by fresh coconut meat
The fresh coconut palm slurry squeezed, then with powder made of spray dry, it is purchased from Tianjin Yi Beijian Bioisystech Co., Ltd；Prebiotics used
And binder, it is purchased from Tianjin Yi Beijian Biotechnology Co., Ltd.
In the preparation process of following embodiment, unless otherwise specified, used means are this field conventional technique
Means.
Embodiment 1
The present embodiment provides a kind of granules for improving bone health, and in terms of mass parts, be made by following raw material: shark is soft
17 parts of bone meal, 1.5 parts of collagen, 40 parts of cucumber seed powder, 39 parts of coconut powder, newborn 2.5 parts of mineral salt, 60 parts of prebiotics and bonding
Agent, the binder are the alcohol of volumetric concentration 80%, and dosage is the 5% of other components total weight.
The present embodiment also provides the preparation method of above-mentioned granule, comprising: prebiotics pulverize and sieve, choose under 60 meshes
Fine powder weighs shark cartilage powder, collagen, cucumber seed powder, coconut powder, newborn mineral salt and prebiotics according to the proportion and sieves lower fine powder,
It is uniformly mixed；Will in the fine powder that mixed be added volumetric concentration 80% alcohol, the particle of 60 mesh is made, under temperature 50 C into
The dry 60min of row, packing to get.
Embodiment 2
The present embodiment provides a kind of granules for improving bone health, and in terms of mass parts, be made by following raw material: shark is soft
17 parts of bone meal, 1.5 parts of collagen, 39 parts of coconut powder, newborn 2.5 parts of mineral salt, 60 parts of prebiotics and binder, the binder are
The alcohol of volumetric concentration 80%, dosage are the 5% of other components total weight.Preparation method is the same as embodiment 1.
Comparative example 1
This comparative example provides a kind of granule, in terms of mass parts, is made by following raw material: 17 parts of shark cartilage powder, collagen
1.5 parts of albumen, 40 parts of milk powder, 39 parts of coconut powder, newborn 2.5 parts of mineral salt, 60 parts of prebiotics and binder, the binder are volume
The alcohol of concentration 80%, dosage are the 5% of other components total weight.Preparation method is the same as embodiment 1.
Comparative example 2
This comparative example provides a kind of granule, in terms of mass parts, is made by following raw material: 5 parts of shark cartilage powder, collagen egg
White 10 parts, 20 parts of cucumber seed powder, 70 parts of coconut powder, newborn 7 parts of mineral salt, 60 parts of prebiotics and binder, the binder are volume
The alcohol of concentration 80%, dosage are the 5% of other components total weight.Preparation method is the same as embodiment 1.
Comparative example 3
This comparative example provides a kind of granule, in terms of mass parts, is made by following raw material: 35 parts of shark cartilage powder, collagen
3 parts of albumen, 65 parts of cucumber seed powder, 35 parts of coconut powder, 60 parts of prebiotics and binder, the binder are the wine of volumetric concentration 80%
Essence, dosage are the 5% of other components total weight.Preparation method is the same as embodiment 1.
Test example
Toxotest
Carry out that Oral toxicity test, (mouse bone marrow cells are thermophilic for binomial mutagenicity test to the product of the embodiment of the present invention 1~6
Polychromatic erythrocytes number micronucleus test and sperm malformation test) and 30 days feeding trials safety evaluatio experiment and pathological tissue
It checks and gross anatomy test, test data does not find that given the test agent has apparent toxic effect, be classified and mark by acute toxicity
Quasi- evaluation, the given the test agent belong to nontoxic grade.
Efficacy test
Study subject: SPF grades female Wistar rats 110.
Experimental method: rat is raised in the environment of 22 DEG C~25 DEG C of room temperature, relative humidity 50%~70%, entire mistake
The daily illumination 12h of rat, drinks deionized water in journey, with 1 week of low calcium forage feed (calcium content 1.5g/kg).Later
Rat is randomly divided into 11 groups, i.e., (new Gaizhonggai board is high for low calcium group (deionized water stomach-filling, 10mL/kgbw), positive controls
Calcium tablet, 0.28g/kgbw), embodiment 1 product, three dosage groups: low dose group 375mg/kgbw, middle dose group 750mg/
Kgbw, high dose group 1500mg/kgbw (5,10,20 times that are respectively equivalent to human intaking amount 75mg/kgbw) are implemented
Example 2 product, three dosage groups: low dose group 375mg/kgbw, middle dose group 750mg/kgbw, high dose group 1500mg/
Kgbw, 1 group of comparative example (1 product 750mg/kgbw of comparative example), 2 groups of comparative example (2 product 750mg/kgbw of comparative example),
3 groups of comparative example (3 product 750mg/kgbw of comparative example), every group 10.It is administered once a day, successive administration 12 weeks, experimental period
Between each group rat with low calcium forage feed, free water.It weighed after the test at the 12nd week, puts to death rat afterwards, separate
Bilateral femur, places it in 105 DEG C of baking ovens that drying to constant weight, and femur dry weight is weighed after being cooled to room temperature；After weighing, be put into through
In the dry triangular flask of HCl treatment cleaning, nitric acid: perchloric acid (volume ratio 4:1) 15mL digestion is added, with deionized water constant volume
To 25mL, using calcium content in atomic absorption spectroscopy determination bone；With bone mineral measuring instrument measurement femur midpoint and
The bone density (BMD) of distal end.
Experimental result is shown in Tables 1 and 2s.
Influence of the table 1 to rat body weight and bone weight
Note:*Indicate P < 0.05 compared with low calcium group.
As shown in Table 1, there was no significant difference (P > 0.05) for weight before each group rat is tested；Each group rat body weight after experiment
Also there was no significant difference (P > 0.05).The right femur bone of embodiment 1 product, three dosage groups is significantly higher than low calcium group and other again
Administration group (P < 0.05), and as the right femur bone weight of the increase of dosage also increases, it is in dose dependent.And the right stock of positive controls
Bone bone weight is only slightly higher compared with low calcium group, but there was no significant difference (P > 0.05).1~3 group of comparative example of right femur bone heavy phase
Low calcium group increased, but unobvious, effect is inferior to embodiment 1 product, three dosage groups.
Influence of the table 2 to rat femur density and calcium content of bone
Note:*Indicate P < 0.05 compared with low calcium group.
As shown in Table 2, compared with low calcium group, each dosage composition group distal end bone density of 1 product of embodiment, midpoint bone are close
Degree and calcium content of bone have conspicuousness to improve (P < 0.05), and are much higher than other administration groups, and have between each dosage of composition
There is dose dependent；Positive controls can effectively improve distal end bone density and midpoint bone density, but mention to calcium content of bone
Ascending effect can not show a candle to product of the embodiment of the present invention；The calcium content of bone that 1~3 group of comparative example increased than low calcium group, but effect is remote
Not as good as embodiment 1,2 product, three dosage groups.
In conclusion according to the evaluation method of the increase bone density test of " health food detection and assessment technique specification ",
Illustrate that composition of the invention not only has the function of supplement calcium, can also improve calcareous absorption, so that it is close to reach increase bone
The effect of degree and calcium content of bone, raising bone health.
Finally, method of the invention is only preferable embodiment, it is not intended to limit the scope of the present invention.It is all
Within the spirit and principles in the present invention, any modification, equivalent replacement, improvement and so on should be included in protection of the invention
Within the scope of.
Claims (8)
1. a kind of composition for improving bone health, which is characterized in that in terms of mass parts, by the raw material system including following components
: 10-30 parts of shark cartilage powder, 1-5 parts of collagen, 30-60 parts of coconut powder and newborn 1-5 parts of mineral salt.
2. composition according to claim 1, which is characterized in that the composition further includes 30-60 parts of cucumber seed powder.
3. composition according to claim 2, which is characterized in that in terms of mass parts, by the raw material system including following components
: 10-20 parts of shark cartilage powder, 1-3 parts of collagen, 30-50 parts of cucumber seed powder, 30-50 parts of coconut powder and newborn mineral salt 1-4
Part.
4. composition according to claim 3, which is characterized in that the raw material is shark cartilage powder, collagen, cucumber
Seed powder, coconut powder and newborn mineral salt.
5. composition according to any one of claims 1 to 4, which is characterized in that granule, capsule is made in the composition
Any dosage form in agent, tablet and electuary.
6. a kind of granule for improving bone health, which is characterized in that including the described in any item compositions of Claims 1 to 4
And auxiliary material, the auxiliary material are prebiotics and binder.
7. granule according to claim 6, which is characterized in that the prebiotics mass parts are 50-100 parts, described viscous
Tie the 2%-10% that agent dosage is remaining component weight.
8. the preparation method of granule as claimed in claim 7 characterized by comprising first distinguish each component and prebiotics
It crushed 60~80 meshes, be then according to the proportion uniformly mixed smashed each component and prebiotics, add binder, make
At the particle of 20~80 mesh, finally drying is dispensed to obtain the final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810732772.2A CN108968075A (en) | 2018-07-05 | 2018-07-05 | It is a kind of improve bone health composition and its application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810732772.2A CN108968075A (en) | 2018-07-05 | 2018-07-05 | It is a kind of improve bone health composition and its application |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108968075A true CN108968075A (en) | 2018-12-11 |
Family
ID=64536231
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810732772.2A Pending CN108968075A (en) | 2018-07-05 | 2018-07-05 | It is a kind of improve bone health composition and its application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108968075A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110973638A (en) * | 2019-11-26 | 2020-04-10 | 康道生物（南通）有限公司 | Crystal-bonded capsule and manufacturing process thereof |
| CN111387397A (en) * | 2020-04-15 | 2020-07-10 | 湖北瑞邦生物科技有限公司 | Bovine bone peptide beverage for improving skeleton and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1903220A (en) * | 2006-07-12 | 2007-01-31 | 江中药业股份有限公司 | Health-care food with function of improving skeletal density and its prepn. method |
| CN102133231A (en) * | 2011-03-23 | 2011-07-27 | 济南康麦国际贸易有限公司 | Product prepared by shark cartilage for supplementing calcium and promoting metabolism and development of cartilage and preparation method thereof |
| CN103141892A (en) * | 2013-02-28 | 2013-06-12 | 康美药业股份有限公司 | Cucumber seed beverage and preparation method and application thereof |
| CN105533712A (en) * | 2015-12-29 | 2016-05-04 | 天津天狮生物发展有限公司 | Composition used for increasing bone density and enhancing immunity |
-
2018
- 2018-07-05 CN CN201810732772.2A patent/CN108968075A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1903220A (en) * | 2006-07-12 | 2007-01-31 | 江中药业股份有限公司 | Health-care food with function of improving skeletal density and its prepn. method |
| CN102133231A (en) * | 2011-03-23 | 2011-07-27 | 济南康麦国际贸易有限公司 | Product prepared by shark cartilage for supplementing calcium and promoting metabolism and development of cartilage and preparation method thereof |
| CN103141892A (en) * | 2013-02-28 | 2013-06-12 | 康美药业股份有限公司 | Cucumber seed beverage and preparation method and application thereof |
| CN105533712A (en) * | 2015-12-29 | 2016-05-04 | 天津天狮生物发展有限公司 | Composition used for increasing bone density and enhancing immunity |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110973638A (en) * | 2019-11-26 | 2020-04-10 | 康道生物（南通）有限公司 | Crystal-bonded capsule and manufacturing process thereof |
| CN111387397A (en) * | 2020-04-15 | 2020-07-10 | 湖北瑞邦生物科技有限公司 | Bovine bone peptide beverage for improving skeleton and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102318835B (en) | Composition for reducing bone loss and preparation method thereof | |
| CN1903220B (en) | Health-care food with function of improving skeletal density and its prepn. method | |
| CN103251671B (en) | A kind of composition and method of making the same containing Chinese medicine increasing bone density | |
| CN106235311A (en) | A kind of compositions promoting skeletal system health and application thereof | |
| CN101711786B (en) | Preparation used for relieving osteoarthropathy and enhancing immunity | |
| CN102423487B (en) | Osteoarticular health-care composition and its application | |
| CN102949710B (en) | Pharmaceutical composition or healthcare product for increasing bone mineral density and preparation method of pharmaceutical composition or healthcare product | |
| CN103083648B (en) | Troche for enhancing bone mineral density based on milk mineral salt as raw material as well as preparation method thereof | |
| CN104705658B (en) | Health food with bone density improving function | |
| CN101695382A (en) | Calcium supplementing preparation with functions of improving bones and joints | |
| CN102805858B (en) | High-efficiency calcium supplement capsule and preparation method thereof | |
| CN101966222A (en) | Medicinal composition and preparation for strengthening bones and preparation method thereof | |
| CN109432388A (en) | The composition and its application in terms of bony articulation health of a kind of probiotics and aminoglucose hydrochloride | |
| CN108968075A (en) | It is a kind of improve bone health composition and its application | |
| CN104605226A (en) | Healthcare product with function of increasing bone mineral density | |
| CN101292739B (en) | Health food having function of increasing bone substance density | |
| CN104824677A (en) | Bone density increase health food and preparation method thereof | |
| CN101401833B (en) | Composition for preventing and/or treating osteoporosis | |
| CN101455396A (en) | Nutrient health-care food capable of promoting bone and bone arthrosis health | |
| CN101268836B (en) | Nutrition high calcium medicinal granule and preparing technique | |
| WO2018107324A1 (en) | Calcium supplement composition for decreasing risk of hypercalcemia and use thereof | |
| CN102626463A (en) | Natural medicine compound for increasing bone mineral density and preventing and treating osteoporosis | |
| CN110897159A (en) | A composition for preventing or treating joint diseases | |
| CN108719970A (en) | A kind of composition, health products and preparation method thereof comprising it increasing bone density | |
| CN104523804B (en) | A kind of capsule for increasing bone density and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20181211 |
|
| RJ01 | Rejection of invention patent application after publication |