CN101455396A - Nutrient health-care food capable of promoting bone and bone arthrosis health - Google Patents
Nutrient health-care food capable of promoting bone and bone arthrosis health Download PDFInfo
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- CN101455396A CN101455396A CNA2009100580561A CN200910058056A CN101455396A CN 101455396 A CN101455396 A CN 101455396A CN A2009100580561 A CNA2009100580561 A CN A2009100580561A CN 200910058056 A CN200910058056 A CN 200910058056A CN 101455396 A CN101455396 A CN 101455396A
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Abstract
The invention provides a health food composition for promoting the health of bones and bone joints, which is a preparation made from the materials containing traditional Chinese medicine oyster and hydrolyzed collagen. Wherein, the weight ratio of the oyster and hydrolyzed collagen is: oyster 500-2000 parts and the hydrolyzed collagen 100-2000 parts. The preparation is used for preventing and treating osteoporosis, hyperosteogeny and osteoarthritis with simultaneous effect to principal and subordinate symptoms The animal tests show that: the composition of the invention has a substantial action to the model of rat osteoporosis caused by ovary resection; it also has the substantial inhibition actions to the foot swelling and adjuvant type arthritis of rat caused by carrageenan. The composition has cooperation synergism, achieves positive functions in reducing bone and joint ache, reducing brittleness and increasing bone mineral density, and is suitable for wide application.
Description
Technical field
The present invention relates to a kind of health-care food composition that promotes bone and bony articulation health, it be contain the Chinese medicine oyster, Hydrolyzed Collagen is the preparation that feedstock production forms, and belongs to the traditional Chinese medicine health care product field.
Background technology
Skeleton mainly is made of collagen two parts of 2/3 calcium salt and 1/3, and articular cartilage mainly is made up of collagen (59%), proteoglycan (ammonia sugar) and cartilage cell etc.The result of Chinese residents nutrition and investigation of health conditions shows, the resident's of urban and urual areas of whole country calcium intake is less than half of recommended intake, had a strong impact on bone health, especially for the children and the teenager of growth and development stage, the elderly is climacteric women particularly, collagen, calcium, the speed that proteoglycan runs off has surpassed bone formation, it is fragile that bone tissue becomes, bone density descends fast, thereby cause osteoporosis, osteoproliferation and osteoarthritis, the whole body bone joint pain, swelling, the degradation phenomenas such as performance of osteoarthritis such as hyperplasia, modern medicine claim " bone declines "; That is to say that " bone declines " is the reason that directly causes bone and bone and joint diseases.Domestic and international multinomial studies show that, take place in the evolution " bone declines ", the nutrition and the metabolism of bone and cartilage have important function, the internal cause of real morbidity is relevant with the Nutrition and Metabolism disorder with bone and cartilage nutritional deficiency, all the time replenishing and keeping osteotrophy is nutrition and reparation bone and osteoarticular normal morphology structure, keep complete physiological function, the important step of prevention of osteoporosis, osteoproliferation and osteoarthritis.
Medical research finds, replenishes the calcium merely not only can not change bone and decline, even increases the fragility of bone and cause the external force fracture.Calcium is the important component part of bone, collagen can make bone have pliability and elasticity, promote the deposition of calcium on bone, improve the utilization rate of bone to calcium, make bone harder, reach high-effect effect of replenishing the calcium, cartilage polysaccharide compositions such as (ammonia sugar) can not be run off, thereby the symptom of osteoporosis, arthralgia is eased.Except that collagen, calcium, also have necessary trace element, chitin, shitosan and the D-Glucosamine etc. of human body, all be the important nutrient of bone and cartilage, natural food is difficult to fully replenish, and takes in very necessary in the meals.
Oyster (Oyster), among the people being commonly called as " oyster ", " oyster ", but be the shellfish marine product of a kind of medicine food with usefulness.Oyster vegetal pole horn of plenty have " seabed milk ", " Hai Zuzhong is your person ", and the Japanese then is called " source of root ", the good reputation of " descending oyster to soly respect celestially ".Oyster is a Chinese medicine relatively commonly used, have transquilization with heavy material, the checking exuberance of yang tonifying yin, softening and resolving hard mass is restrained astringent or styptic treatment for spontaneous sweating effect.Be used for the palpitation with fear insomnia, dizzy tinnitus, the scrofula subcutaneous nodule, note of the ancient Chinese lump in the abdomen lump in the abdomen, spontaneous sweating, band is collapsed in seminal emission, stomachache pantothenic acid.The calcined oyster shell convergence is astringent or styptic treatment for spontaneous sweating; Be used for spontaneous sweating, band is collapsed in seminal emission, the stomachache acid regurgitation.
Collagen is the maximum protein of mammal in-vivo content, accounts for the 25%-30% of body internal protein total amount, is equivalent to 6% of body weight.Hydrolyzed Collagen is that collagen forms through enzymolysis, and Main Ingredients and Appearance is a collagen polypeptide, and molecular weight is 2000-4000D, can directly absorb at enteron aisle, and than amino acid bigger uptake be arranged.
Patent CN1454646, CN1460498, CN1824249 disclose the compound preparation that oyster adds strong bone Chinese medicine and have been used for the treatment of osteoporosis, CN1500523 discloses the protein formulation that strengthens sclerotin, form by collagen and amino acid chelated calcium, calcium gluconae, calcium carbonate, CN1669582 discloses collagen and has added calcium must be convenient to absorption of human body collagen calcium after resolution process, CN1785427 discloses a kind of compound calcium preparation for astronaut, is made up of calcium carbonate, collagen peptide, stachyose, VD3.But also be not the preparation report of Main Ingredients and Appearance so far with Chinese medicine oyster and Hydrolyzed Collagen.
Summary of the invention
Technical scheme of the present invention provides a kind of and has had the sample smelting of holding concurrently, and is used to prevent and treat the pharmaceutical composition of osteoporosis, osteoproliferation and osteoarthritis, and it is a kind of Chinese medicine oyster and Hydrolyzed Collagen composition of pure natural.
The invention provides a kind of health-care food composition that promotes bone and bony articulation health, it be by contain the Chinese medicine oyster, Hydrolyzed Collagen is the preparation that feedstock production forms, wherein, the weight proportion of oyster, Hydrolyzed Collagen is:
Oyster 500-2000 part, Hydrolyzed Collagen 100-2000 part.
Further preferably, the preferred weight proportioning of described oyster, Hydrolyzed Collagen is:
Oyster 800-1200 part, Hydrolyzed Collagen 500-1000 part.
Still more preferably, the weight proportion of described oyster, Hydrolyzed Collagen is:
1000 parts of oysters, 1000 parts of Hydrolyzed Collagens.
Wherein, the molecular weight of described Hydrolyzed Collagen is 2000-4000D.
Wherein, the amount that comprises vitamin D in the described raw material is 0.005-0.01 part.
Wherein, described preparation is: tablet, capsule, granule or oral liquid.
The present invention also provide said composition in the preparation prevention or/and treat purposes in osteoporotic medicine or the health food.
The present invention also provides said composition to prevent or/and the medicine of treatment osteoproliferation or the purposes in the health food in preparation.
The present invention also provides said composition to prevent or/and the medicine of treatment osteoarthritis or the purposes in the health food in preparation.
The present invention uses Chinese medicine oyster and Hydrolyzed Collagen compatibility, be not only synergistic function, and osteoporosis, osteoarthritis had an effect for the treatment of both principal and secondary aspect of disease, its special effect, effect is lasting, safe and reliable, be prevention at present and treatment osteoporosis, the optimal composition of osteoarthritis, can be widely used in medicine and field of health care food.
Obviously, according to foregoing of the present invention,,, can also make modification, replacement or the change of other various ways not breaking away under the above-mentioned basic fundamental thought of the present invention prerequisite according to the ordinary skill knowledge and the customary means of this area.
The specific embodiment
Below by testing effective effect of further setting forth composition of the present invention.
The preparation of embodiment 1 present composition tablet
Take by weighing raw material by following proportioning
Oyster 500g Hydrolyzed Collagen 1500g
Production method is as follows:
With oyster ultramicro grinding to 200 order fine powder; With itself and Hydrolyzed Collagen and an amount of excipient mixing, granulate, compressing tablet promptly gets 2000 in tablet again.
The preparation of embodiment 2 present composition capsules
Take by weighing raw material by following proportioning
Oyster 500g Hydrolyzed Collagen 2000g
Production method is as follows:
With oyster ultramicro grinding to 200 order fine powder; With itself and Hydrolyzed Collagen and an amount of excipient mixing, granulate again, encapsulated, promptly get 2000 of capsules.
The preparation of embodiment 3 present composition granules
Take by weighing raw material by following proportioning
Oyster 1000g Hydrolyzed Collagen 1000g
Production method is as follows:
With oyster ultramicro grinding to 200 order fine powder; With itself and Hydrolyzed Collagen and an amount of excipient mixing, granulate, packing promptly gets granule again, and every bag of 5g adorns 1000 bags altogether.
The preparation of embodiment 4 present composition oral liquids
Take by weighing raw material by following proportioning
Oyster 2000g Hydrolyzed Collagen 100g
Production method is as follows:
With oyster ultramicro grinding to 200 order fine powder; With itself and Hydrolyzed Collagen mixing, add suitable quantity of water and flavouring again, stir evenly, packing promptly gets the 10ml oral liquid, 2000 bottles.
The preparation of embodiment 5 medicine oral liquids of the present invention
Take by weighing raw material: oyster 800g, Hydrolyzed Collagen 1000g, cholecalciferol 5mg press the method preparation of embodiment 4.
The preparation of embodiment 6 medicinal granules of the present invention
Get oyster 1200g, Hydrolyzed Collagen 500g, cholecalciferol 10mg presses the method preparation of embodiment 3.
The inventor confirms can bring into play synergy by proper proportion through years of researches.Below by concrete Ergonomy evidence beneficial effect of the present invention.
Test example 1 present composition causes the influence of osteoporosis rat model to oophorectomize
1. the animal behavior change dynamics is observed
90 of 300 gram left and right sides Wistar female rats, spay is divided into 9 groups at random by body weight, by oophorectomize being caused the modeling of osteoporosis rat model, find in the experiment that rat is after 3 weeks of operation, model group and normal group are relatively, movable slow, One's spirits are drooping depressed, slow in reacting, hair is sparse gradually, test 1-5 group (embodiment 2-6), positive group (the precious particle of bone pine), control group (oyster group), control group also all has identical performance; After the administration 1 month, test 1-5 group, positive group and model group compare, and hair is bright and clean gradually, and spirit and activity are normal gradually.
2. the whole bone density of rat is measured in administration after two months
The whole after two months bone density of table 1 rat administration relatively
Annotate: and model group is relatively, * P＜0.05, * * P＜0.01; Compare #P＜0.05 with control group.
As can be known from the above table, model group and normal group compare, and whole bone density significantly reduces (* * P＜0.01), the modeling success; Test 1-5 group, positive group and model group and compare, bone density significantly increases (* P＜0.05, * * P＜0.01); Compare #P＜0.05 with control group.
Therefore in administration after two months, test 1-5 group has shown certain curative effect, compares there was no significant difference with positive drug.Wherein, 2,4,5 groups of effects of test are more excellent; The effect of test 2 is the most remarkable.
Rat live body lumbar spine bmd is measured in administration after two months
Table 2 rat administration live body lumbar spine bmd is after two months compared
Annotate: and model group is relatively, * * P＜0.01, * P＜0.05; Compare ##P＜0.01, #P＜0.05 with control group.
As can be known from the above table, model group and normal group comparison, lumbar spine bmd significantly reduces (* P＜0.05), modeling success, and model group lumbar spine bmd and self whole bone density comparison, lumbar vertebra is lost even more serious; Test 1-5 group, positive group and model group relatively, bone density significantly increases (* P＜0.05, * * P＜0.01), with control group relatively, bone density significantly increases (##P＜0.01, #P＜0.05).
Therefore in administration after two months, test 1-5 group has shown anti-oophorectomize and has caused the osteoporosis rat better action, compares there was no significant difference with positive drug.Wherein, it is more excellent to test 2,4,5 groups of effects, the most remarkable to test 2 groups effect.
Test example 2 present composition on Carrageenan are brought out the influence of rat foot claw swelling test
Choosing body weight is 50 of 150-180 gram Wistar male rats, be divided into five groups at random, every group 10, after the right back sufficient pawl volume of rat is respectively organized in measurement, first, second and third group rat is irritated stomaches by embodiment 3 respectively and gives embodiment 3 composition 360mg/kg, 180mg/kg, 90mg/kg (middle dosage is equivalent to people's clinical equivalent dosage 2000mg/ days/60kg), the 4th group of rat oral gavage gives positive control drug aminoglucose hydrochloride 314mg/kg, it is mixed with finite concentration and irritates the long-pending 1ml/100 gram body weight that is of body of stomach, irritates stomach equal volume distilled water for the 5th group big group.
After the administration 1 hour, organize the right back sufficient plantar subcutaneous injection 1% carrageenan 0.1ml/ of rat to each and only cause inflammation, cause scorching back and respectively surveyed one time the right back sufficient pawl volume-variation of rat in 1,2,3,4,5,6 hour, so that the difference of the sufficient pawl volume in scorching front and back is as the swelling degree.
Calculate and respectively organize rat foot claw swelling degree average and standard deviation, and make t check, relatively each administration group and blank group difference conspicuousness.The results are shown in Table 3.
Table 3 composition on Carrageenan is brought out rat foot claw swelling and is influenced result of the test
Compare * P＜0.01 with the blank group.
By table 3 as seen, composition is compared with the blank group, (360mg/kg, 180mg/kg), the rat foot claw swelling brought out of positive control drug (314mg/kg) on Carrageenan all had remarkable inhibitory action in 1-6 hour that measures, middle dosage is optimal dose to senior middle school's dosage group.
Test example 3 present compositions are to the influence of rat assist agent arthritis test
Choose 60 of body weight 150-180 gram Wistar male rats, be divided into 6 groups at random, every group 10, measure respectively organize the right back sufficient corpus unguis of rat long-pending after, one, two, three groups of rats are irritated stomach respectively and give embodiment 3 compositions (being called for short PA) 360mg/kg, 180mg/kg, (middle dosage is equivalent to people's clinical equivalent dosage 2000mg/ days/60kg) to 90mg/kg, four, five, six groups of rats are irritated stomach respectively and give positive controls oyster 180mg/kg, Hydrolyzed Collagen group 180mg/kg, irritate stomach with volume distilled water, the administration water volume is 1ml/100 gram body weight, each organized the rat oral gavage administration after 1 hour, one, two, three, four, five, (LIFE TECHNOLOGIES's six groups of right back sufficient sole of the foot intracutaneous injection Freund's complete adjuvants of the every mouse of rat produces, the 10ml/ bottle, lot number 1005345) 0.1ml, behind the injection adjuvant 18 hours, it is long-pending to measure the right back sufficient corpus unguis of above-mentioned seven groups of rats, with the difference of giving sufficient pawl volume before and after the adjuvant as the swelling degree.Calculate and respectively organize rat foot claw swelling degree average and standard deviation and do seven checks, relatively one, two, three, five administration rats and the 6th group model group difference conspicuousness the results are shown in Table 4.
Table 4 composition (PA) and control group are to the influence of adjuvant-induced arthritis test rat local inflammation
| Group | Number of animals (only) | Body weight (gram) | Dosage (mg/kg) | Give adjuvant front foot corpus unguis long-pending (ml) | To swelling volume (ml) behind the adjuvant |
| The PA high dose group | 10 | 167±11 | 360 | 0.767 | 0.496±0.066**# |
| Dosage group among the PA | 10 | 166±11 | 180 | 0.772 | 0.487±0.046**# |
| The PA low dose group | 10 | 164±10 | 90 | 0.754 | 0.590±0.06* |
| The oyster group | 10 | 164+10 | 180 | 0.760 | 0.610±0.076 |
| The Hydrolyzed Collagen group | 10 | 167+10 | 180 | 0.765 | 0.600±0.059 |
| Model group | 10 | 165±9 | With volume distilled water | 0.779 | 0.660±0.067 |
Compare with model group, * P＜0.05, * * P＜0.01 and oyster group, Hydrolyzed Collagen group are than #P＜0.01.
By table 4 as seen, combination object height, middle dosage group, positive controls, oyster group, Hydrolyzed Collagen have inhibitory action to the local inflammation that adjuvant causes.Under identical dosage, the middle dosage group effect of composition obviously is better than oyster group, Hydrolyzed Collagen group (P＜0.05), and middle dosage group is an optimal dose.The composition pharmacodynamics obviously is better than single oyster and list used and uses Hydrolyzed Collagen, illustrates that oyster and Hydrolyzed Collagen have synergistic function.
Above-mentioned pharmacodynamics test proves, oyster of the present invention and Hydrolyzed Collagen have been not only synergistic function, and osteoporosis, osteoarthritis had an effect for the treatment of both principal and secondary aspect of disease, oyster and hydrolytic collagen compatibility are used, be not simple dose-effect relationship, effect the best of 180mg/kg performance under middle dosage.The present composition is used for prevention and treats osteoporosis, the optimal selection of osteoarthritis.
Claims (9)
1, a kind of health-care food composition that promotes bone and bony articulation health is characterized in that: it be by contain the Chinese medicine oyster, Hydrolyzed Collagen is the preparation that feedstock production forms, wherein, the weight proportion of oyster, Hydrolyzed Collagen is:
Oyster 500-2000 part, Hydrolyzed Collagen 100-2000 part.
2, want 1 described composition according to right, it is characterized in that: the weight proportion of described oyster, Hydrolyzed Collagen is:
Oyster 800-1200 part, Hydrolyzed Collagen 500-1000 part.
3, want 2 described compositions according to right, it is characterized in that: the weight proportion of described oyster, Hydrolyzed Collagen is:
1000 parts of oysters, 1000 parts of Hydrolyzed Collagens.
4, according to the arbitrary described composition of claim 1-3, it is characterized in that: the molecular weight of described Hydrolyzed Collagen is 2000-4000D.
5, want 1 described composition according to right, it is characterized in that: described preparation is: tablet, capsule, granule or oral liquid.
6, want 5 described compositions according to right, it is characterized in that: the amount that contains vitamin D in every preparation unit is 0.005-0.01 part.
7, each described composition of claim 1-6 in preparation prevention or/and treat purposes in osteoporotic medicine or the health food.
8, each described composition of claim 1-6 prevents or/and the medicine of treatment osteoproliferation or the purposes in the health food in preparation.
9, each described composition of claim 1-6 prevents or/and the medicine of treatment osteoarthritis or the purposes in the health food in preparation.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2009100580561A CN101455396A (en) | 2009-01-07 | 2009-01-07 | Nutrient health-care food capable of promoting bone and bone arthrosis health |
| CN2009102460386A CN101926978A (en) | 2009-01-07 | 2009-11-20 | Medicine composition for promoting bone and bony articulation health |
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| CNA2009100580561A CN101455396A (en) | 2009-01-07 | 2009-01-07 | Nutrient health-care food capable of promoting bone and bone arthrosis health |
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| CN2009102460386A Pending CN101926978A (en) | 2009-01-07 | 2009-11-20 | Medicine composition for promoting bone and bony articulation health |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102349653A (en) * | 2011-10-14 | 2012-02-15 | 李泼 | Bone-invigorating collagen calcium granules |
| WO2018166807A1 (en) * | 2017-03-15 | 2018-09-20 | Rousselot B.V. | Compositions of hydrolyzed collagen peptides and commensal microorganisms and methods thereof |
| CN110537698A (en) * | 2018-05-28 | 2019-12-06 | 许昌神飞航天生物科技有限公司 | nutritional preparation suitable for improving bone density of astronaut |
| EP3581191A1 (en) * | 2018-06-15 | 2019-12-18 | Jeju National University Industry-Academic Cooperation Foundation | Composition for improving bone health, including functional fermented material using oysters |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104799280A (en) * | 2015-04-10 | 2015-07-29 | 山东安然纳米实业发展有限公司 | Health-care food with immunity enhancing and bone density increasing functions |
| WO2018170034A1 (en) * | 2017-03-15 | 2018-09-20 | University Of Rochester | Compositions of oligofructose and commensal microorganisms and methods thereof |
-
2009
- 2009-01-07 CN CNA2009100580561A patent/CN101455396A/en active Pending
- 2009-11-20 CN CN2009102460386A patent/CN101926978A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102349653A (en) * | 2011-10-14 | 2012-02-15 | 李泼 | Bone-invigorating collagen calcium granules |
| WO2018166807A1 (en) * | 2017-03-15 | 2018-09-20 | Rousselot B.V. | Compositions of hydrolyzed collagen peptides and commensal microorganisms and methods thereof |
| US11110147B2 (en) | 2017-03-15 | 2021-09-07 | Rousselot B.V | Collagen hydrolysates as a beneficial prebiotic and their effect on joint inflammation and osteoarthritis |
| CN110537698A (en) * | 2018-05-28 | 2019-12-06 | 许昌神飞航天生物科技有限公司 | nutritional preparation suitable for improving bone density of astronaut |
| EP3581191A1 (en) * | 2018-06-15 | 2019-12-18 | Jeju National University Industry-Academic Cooperation Foundation | Composition for improving bone health, including functional fermented material using oysters |
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| CN101926978A (en) | 2010-12-29 |
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