CN106135890A - A kind of alimentation composition contributing to bony articulation health - Google Patents
A kind of alimentation composition contributing to bony articulation health Download PDFInfo
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Abstract
The alimentation composition of a kind of applicable skeleton and patients with joint diseases that the present invention provides, its be by 20～40% marine fish oligopeptide, 10～30% bone collagen peptide, 1～5% organic calcium, 1～5% phosphopeptide caseinate, 0.1～1% Saussurea involucrata culture, 1～5% shark cartilage powder, 5～20% inulin, 5～30% oligosaccharide, 0.1～1% vitamin, 1～3% the plurality of raw materials such as mineral be made.The present invention is directed to skeleton and the deficiency of the physiological characteristics of patients with joint diseases, nutritional need and conventional dietary thereof, a kind of applicable skeleton and patients with joint diseases is provided to eat the sea dietary containing marine fish oligopeptide and bone collagen peptide, this food has and improves body nutriture, promotes skeleton and joint recovering, and the effect such as assist control blood glucose, conditioning human body function of intestinal canal.
Description
Technical field
The invention belongs to nutraceutical field, relate to a kind of applicable joint disease edible for patients food formula of special diet containing marine fish oligopeptide with bone collagen peptide.
Background technology
The B&J diseases such as all kinds of arthritis that middle-aged and elderly people is susceptible to suffer from, bursitis, synovitis, cervical spondylosis, lumbar spondylosis, scapulohumeral periarthritis, hyperosteogeny, rheumatic arthritis, femur head necrosis, osteoporosis have the biggest impact to the life of patient, serious meeting causes the consequences such as fracture, joint deformity, paralysis, this result allows the body and mind of people deeply groan, and has carried many miseries also to patient household.
Osteoarthritis (osteoarthritis, OA), also known as degenerative osteoarthritis, is modal joint disease, especially endangers senior health and fitness, and bring heavy burden to society.In over-65s crowd, the prevalence of radiology OA is up to more than 50%, and more than 75 years old in crowd, this numerical value can reach about 80%.The survey data of the U.S. shows, OA is that No. 2 killer causing more than 50 years old male's disablement is only second to cardiovascular disease.Along with the world and the acceleration of Chinese society aged tendency of population, OA has increasingly becomed the hot topic of doctors and patients or even social concerns.
Normal meals, pass through rational allocation, although ensure that containing nutritional labelings such as rich in protein, fat, vitamin, mineral, but the content of collagenic protein is little, is unfavorable for growth and the reparation of skeleton.So, need with patients with joint diseases's special dietary for skeleton, prepare food of special nutrients, meet nutritional need, be more beneficial for promoting skeleton and joint disease rehabilitation.
For food of special nutrients, there are corresponding regulation and exploitation application in the developed country such as the U.S., European Union.China is by named for food of special nutrients " food for special foods ", and at " pre-packaged food for special foods label general rule " (GB13432-2013) of China
Middle regulation, food for special foods is to meet special health or physiological situation and (or) the special diet demand meeting under the state such as disease, disorder, special processing or the food of formula.According to this theoretical and standard, skeleton and joint disease crowd have the nutritional need being different from ordinary person, the most also should give nutritional supplementation targetedly.
About the special dietary seafood formula of patient with bone disease, have and report as follows:
Patent CN200810006605.6 provides a kind of formula eating the food for special foods containing small peptide for patient with bone fracture, this food is with food-borne small peptide as primary raw material, add the medicine-food two-purpose Chinese herbal medicine extract such as Fructus Mori, Radix Puerariae, it is aided with oligosaccharide, vitamin and mineral again, forms compound prescription.
CN201010290787.1 discloses the sea dietary that a kind of patient with bone disease is special, this spy's dietary seafood is with food-borne marine oligopeptide as primary raw material, add marine bioactivity polysaccharide, then be aided with Sargassum powder, nutrient amino acids, oligosaccharide, vitamin and mineral and be mixed with and form.
According to the nutritional need of skeleton Yu joint disease crowd, prepare special nutraceutical, give the nutritional supplementation of necessity, be the effective way promoting skeleton with joint repair.Inventor, through repeatedly repetition test, finally determines the new compositions of the present invention.Marine fish oligopeptide, bone collagen peptide, organic calcium, phosphopeptide caseinate, as the main active of skeleton Yu joint recovering.Marine fish oligopeptide, bone collagen peptide compound use, can be that bone repair supplements desired nutritional, can be quickly converted to ossein, beneficially bone repair in human body.Organic calcium and the phosphopeptide caseinate of calcium absorption, inulin can be promoted, it is adaptable to be susceptible to suffer from the mid-aged population of B&J disease.With the compatibility such as functional food ingredient Saussurea involucrata culture, shark cartilage powder, play antiinflammatory, analgesic activity.
Summary of the invention
It is an object of the invention to for skeleton and the deficiency of the physiological characteristics of patients with joint diseases, nutritional need and conventional dietary thereof, a kind of applicable skeleton and patients with joint diseases is provided to eat the sea dietary containing marine fish oligopeptide and bone collagen peptide, this food has and improves body nutriture, promotes skeleton and joint recovering, and the effect such as assist control blood glucose, conditioning human body function of intestinal canal.
The compositions of a kind of applicable skeleton and patients with joint diseases that the present invention provides, it contains following raw material: marine fish oligopeptide, bone collagen peptide, organic calcium, phosphopeptide caseinate, Saussurea involucrata culture, shark cartilage powder, inulin, oligosaccharide, vitamin, mineral.It is characterized in that being made up of the raw material of following weight portion:
Marine fish oligopeptide 20～40 parts
Bone collagen peptide 10～30 parts
Organic calcium 1～5 parts
Phosphopeptide caseinate 1～5 parts
Saussurea involucrata culture 0.1～1 part
Shark cartilage powder 1～5 parts
Inulin 5～20 parts
Oligosaccharide 5～30 parts
Vitamin 0.1～1 part
Mineral 1～3 parts.
In above-mentioned composition:
Described marine fish oligopeptide may refer to molecular weight less than 1000 daltonian little molecule oligopeptides, by low temperature enzymolysis, macromolecular collagen protein in marine fish fish scale, fish skin or fishbone is transformed, is stable components, biological activity height, the little molecule oligopeptide of good absorbing.
Described bone collagen peptide is the activity polypeptid substance extracted from animal bone.
Described organic calcium is one or more mixing in calcium gluconate, calcium lactate, calcium citrate, calcium acetate.
Described Saussurea involucrata culture is wild Herba Saussureae Involueratae callus artificial culture's thing.
A kind of chondroitin sulfate that described shark cartilage powder is made up of shark cartilage and the complex of protein.
Described oligosaccharide is oligomeric isomaltose, oligofructose, soybean oligo saccharide, oligomeric xylose one therein, several or all mix.
Described vitamin is vitamin A, vitamin D, vitamin E, vitamin K, vitamin C, vitamin B1, vitamin B2, vitamin B6, vitamin B12, nicotinic acid, folic acid, pantothenic acid, choline, biotin one therein, several or all mix.
Described mineral is calcium, phosphorus, potassium, sodium, magnesium, chlorine, ferrum, zinc, selenium, copper, manganese, iodine, fluorine, chromium, molybdenum one therein, several or all mix.
The compositions of the present invention is powder or granule.Above-mentioned various dispensing mix homogeneously, can keep its powdery, or through pelletize, makes powdery or granule state food.
Present invention also offers the preparation method of above-mentioned composition, comprise the following steps: weigh raw material according to proportioning, the component close according to weight ratio first mixes, and amplifies mixing step by step from weight ratio lower portion, and mix homogeneously in three-dimensional mixer to obtain final product.
The special meals formula supplying skeleton and articulation health sick people to eat that the present invention provides has the following advantages.
Marine fish oligopeptide
Marine fish oligopeptide is the little molecular glue collagen oligopeptide extracted from deep-sea fish skin, fishbone, can be directly by body intestinal absorption and utilization.Having research to confirm, marine fish oligopeptide can promote the synthesis of human bone collagen protein, and collectively promote new bone formation with osteocyte and the mineral such as calcium, phosphorus, and regulate Ca,P metabolism, increases bone doped calcium.Its mechanism of action is likely due to the oligomeric Toplink of marine fish and promotes osteoblastic propagation and differentiation, promoting bone growing, has synergism to increasing bone amount；Meanwhile, marine fish oligopeptide may suppress propagation and the differentiation of osteoclast, reduces bone resorption and bone loss；It additionally is able to promote that skeleton, to the absorption of mineral element such as calcium and utilization, benefits the rehabilitation of skeleton.
Bone collagen peptide
Bone collagen peptide is the activity polypeptid substance extracted from animal bone.Research shows: collagen polypeptide has a lot of active function, such as resisting hypertension, prevents and treatment osteoarthritis and the disease such as osteoporosis, treatment gastric ulcer, defying age and antioxidation etc..Additionally, the absorption of mineral can be promoted, the function such as fat-reducing.Through research, U.S. FDA concludes that collagen peptide has potential therapeutical effect to osteoarthritis and osteoporosis, long-term taking is the most safely and effectively.2002, Oesserand Seifer reported, collagen polypeptide can stimulate chondrocyte synthesis collagen Chromobindin-4 (collagen protein II is osteoarticular main foundation), and can affect collagen conversion in osteoarthrosis.Msokowitz RW reports, collagen polypeptide is a kind of potential therapeutic substance to osteoarthritis and osteoporosis.Clinical research confirmation, daily intakes a certain amount of (10g) collagen polypeptide, and osteo-arthritic pain has substantially reduction.
Organic calcium
Calcium preparation selects the organic calcium such as calcium citrate, calcium lactate or calcium gluconate, middle-aged and elderly people gastric acid secretion is less, digestion power is poor, organic calcium good water solubility, absorption process need not gastric acid and participate in, stimulate little to digestive tract, it is easy to absorbs, it is adaptable to middle-aged and elderly people supplement calcium.
Phosphopeptide caseinate (CPPs)
CPPs is with milk casein as raw material, through the single or hydrolysis of compound protease, then the natural physiological active peptide containing phosphoserine bunch that hydrolyzate is obtained after isolated and purified.CPPs can be with divalent minerals ions binding such as calcium, ferrum, zinc, selenium in the small intestine condition of animal, prevent precipitation, strengthen the concentration of enteral dissolvable mine material such that it is able to promote that intestinal mucosa is to calcium, ferrum, zinc, selenium, especially the absorption of calcium and utilization, be described as " mineral carrier ".Zoopery shows, CPPs can promote absorbing of calcium, reduces the effect of osteoclast, the re-absorption of suppression bone.
Herba Saussureae Involueratae culture
Saussurea involucrata culture is wild Herba Saussureae Involueratae callus artificial culture's thing, contain the functional components such as flavone, polysaccharide, chlorogenic acid, ligustrin after testing, it contains abundant nutrient substance, wherein protein content 28.8%, fat 0.96%, total sugar 25.6%, starch 16.0%, cellulose 10.0% and the trace element of needed by human.Saussurea involucrata culture anti-inflammatory and antalgic aspect has prominent effect, Xuelianhuangtong class is the main component of anti-inflammatory analgesic, can promote the synthesis of adrenocortical hormone, long-term taking Saussurea involucrata culture can also play enhancing body immunity, slow down aging, prevent radiation, prevention cardiovascular diseases, cancer and the effect of other diseases simultaneously.
Shark cartilage powder
Main component in shark cartilage powder is protein (about 40%) and glycosaminoglycans (chondroitin sulfate, 5%～20%), and remaining main component is calcium salt.Chondroitin sulfate has the effect repaired joint tissue, alleviate arthritis ache.Chondroitin sulfate can directly supplement the matrix components of cartilage, reduce the degraded of cartilaginous element, the metabolism of promotion chondrocyte, recovery chondrocyte matrix secretion capacity, the activity of the suppression multiple collagenase of intraarticular.Moisture can be sucked proteoglycan intramolecular by chondroitin sulfate, makes cartilage thickening, and increases IA synovial fluid amount, and synovia is provided that pad effect, relaxes on impact and friction, thus alleviates arthralgia.
Oligosaccharide
Oligosaccharide, also known as oligosaccharide, refers to be connected by glycosidic bond the low polymerization sugar of the straight or branched formed by 2～10 monosaccharide.Functional oligose is the most digested, do not utilized by most intestinal putrefaction bacteria, but beneficial bacteria lactobacillus and the growth and breeding of bacillus bifidus in can promoting human body, such that it is able to suppression putrefaction bacteria growth, contribute to improving and maintaining intestinal normal function.Be eaten for a long time can with slow down aging, relieving constipation, raising immunity, alleviate burden of liver, improve nutrition absorption rate, particularly can improve body to calcium, ferrum, the absorption of zinc ion.
Inulin
Take in inulin and can increase the absorbtivity (such as Ca, Mg, Fe) of important minerals, and increase the density of bone mineral.The metabolite of inulin can promote the self-assembling formation of vitamin B1, B2, B3, B6, B12 and folic acid, thus improves the metabolism of human body, improves immunity and premunition.
Vitamin and mineral:
Vitamin and mineral are the nutrients of needed by human.The vitamin added in the present invention is vitamin A, vitamin D, vitamin E, vitamin K, vitamin C, vitamin B1, vitamin B2, vitamin B6, vitamin B12, nicotinic acid, folic acid, pantothenic acid, choline, biotin one therein, several or all mix.
The mineral added in the present invention is calcium, phosphorus, potassium, sodium, magnesium, chlorine, ferrum, zinc, selenium, copper, manganese, iodine, fluorine, chromium, molybdenum one therein, several or all mix.Mineral of the present invention is added to the organic or inorganic compound of this mineral.
In the present invention, the addition of vitamins and minerals performs with reference to " DRIs " (2013 editions) and " food enrichment use standard " (GB14880-2012).
2, the present invention have developed a kind of special meals food formula using the mixed preparing such as marine fish oligopeptide, bone collagen peptide, organic calcium, phosphopeptide caseinate, oligosaccharide, Saussurea involucrata culture, shark cartilage powder, compound vitamin and mineral.By the organic assembling of various dispensings, and by the synergism between effective ingredient, it is possible to make the effect of functional factor be enhanced.The food made by inventive formulation can effectively supplement skeleton and joint patient's desired nutritional, promotes skeletal joint reparation.
Formula is with marine fish oligopeptide, bone collagen peptide, organic calcium, phosphopeptide caseinate, as the main active of skeleton Yu joint recovering；Using Saussurea involucrata culture, shark cartilage powder as Supplementary active ingredients.Marine fish oligopeptide and bone collagen peptide compound use, can be that bone repair supplements desired nutritional, can be quickly converted to ossein, beneficially skeleton and joint repair in human body.Organic calcium and the phosphopeptide caseinate of calcium absorption, oligosaccharide, inulin can be promoted, it is adaptable to be susceptible to suffer from the mid-aged population of B&J disease.Functional food ingredient Saussurea involucrata culture has the effect of anti-inflammatory analgesic.Chondroitin sulfate in shark cartilage powder has the effect repaired joint tissue, alleviate arthritis ache
Through it is experimentally confirmed that the compositions that the present invention provides has promotion skeleton and the collaborative of joint disease rehabilitation is rented, effect is better than prior art.
Detailed description of the invention:
Following example are used for illustrating the present invention, but are not limited to the scope of the present invention.
Embodiment 1: be applicable to the special diet formula powder of skeleton and joint disease crowd
1, formula composition (gross weight 10kg):
Marine fish oligopeptide 3.0kg, bone collagen peptide
2.0kg
Calcium citrate 0.2kg, phosphopeptide caseinate
0.5kg、
Saussurea involucrata culture 0.1kg, shark cartilage powder 0.2kg,
Inulin 1.0kg, oligomeric isomaltose
2.0kg
Vitamin A 0.1g, vitamin E 2g, vitamin C 25g, vitamin B1 0.4g, vitamin B2 0.4g, vitamin B6 0.4g, vitamin B12 0.4 g, nicotinic acid 0.4g, folic acid 0.1g, pantothenic acid 2g, choline 40g
Potassium 100g, magnesium 100g, ferrum 5g, zinc 5g, selenium 0.01g, manganese 1g
Adjuvant surplus
2, preparation method:
1) above-mentioned material is weighed according to formula；
2) first mixing according to the component that weight ratio is close, the part smaller from weight amplifies mixing step by step, mixes in three-dimensional
Mix homogeneously in conjunction machine；
3) with the material that powdery automatic packaging machine subpackage is mixed, every bag of 10g.
Embodiment 2:
1, formula composition (gross weight 10kg)
Marine fish oligopeptide 4.0kg, bone collagen peptide
3.0kg
Calcium citrate 0.3kg, phosphopeptide caseinate
0.4kg、
Saussurea involucrata culture 0.05kg, shark cartilage powder 0.4kg,
Inulin 2.0kg, oligomeric isomaltose
1.0kg
Vitamin A 0.2g, vitamin E 3g, vitamin C 30g, vitamin D 0.1g, vitamin B1 0.5g, vitamin B2 0.5g, vitamin B6 0.5g, vitamin B12 0.1g, nicotinic acid 0.5g, folic acid 0.1g, pantothenic acid 1g, choline 50g
Potassium 100g, magnesium 100g, ferrum 5g, zinc 5g, selenium 0.01g, manganese 1g, chromium 0.01g, copper 0.1g, molybdenum 0.01g
Adjuvant surplus
2, preparation method is with embodiment 1.
Embodiment 3: efficacy validation is tested
About contributing to joint injury reparation and promoting the improvement result of function of joint, country does not still have corresponding code test and evaluation methodology at present, following invention group is according to the related symptoms of joint disease and untoward reaction, devise test battery targetedly, for investigating clinical effectiveness and the safety of the present invention further, now result of the test is summarized as follows.
Subject Population, selects knee osteoarthritis patients 100 example, uses the method for random packet to be divided into test-meal group 50 example (male 17 example, women 33 example), matched group 50 example (male 20 example, women 30 example).Two groups of ages, sex, the course of disease, pain VAS are scored, dysfunction and pressure pain compare, difference that there are no significant (P > 0.05), have comparability.
Basic condition table tested by table 1
| Group | N | Age (year) | Sex (male/female) | The course of disease (year) |
| Matched group | 50 | 58~70 | 20/30 | 2.3~4.21 |
| Test-meal group | 50 | 56~74 | 17/33 | 1.9~4.61 |
Test-meal group takes the product in the embodiment of the present invention 1, every day 1 time, and each 10g, bath is taken；Matched group takes the starch placebo that outward appearance is identical with this product, and instructions of taking is consistent with test-meal group.Time of Administration 60 days, experimenter does not uses other oral or the medicine improving osteoarthritis of external before taking and during taking.
MAIN OUTCOME MEASURES: function of joint improves experiment.
Follow up time: follow up time is 60 days, follows up a case by regular visits to 90 examples.
Statistical analysis: use SPSS variance analysis.
Result: by purpose Treatment Analysis, case all enters
Table 2 standards of grading:
Before and after the group treatment of 3 liang of table, symptom integral improves situation
Before test-meal, the symptom integral difference of two groups is little, and after the test-meal of 60 days, it is different that the symptom integral of two groups reduces degree.Reduce notable after test-meal group test-meal relative to matched group symptom integral.Untoward reaction and side effect is all there is not in all experimenters during the test-meal of 60 days.
Brief summary: above result of the test shows, product of the present invention contributes to joint disease crowd and is improved in terms of the untoward reaction such as the gonalgia, tenderness, dysfunction and improves, and has and contributes to joint injury reparation and promote the improvement result of function of joint.
Claims (10)
1. an alimentation composition, it is characterised in that described alimentation composition, it is prepared and includes marine fish oligopeptide, bone collagen peptide, organic calcium, phosphopeptide caseinate, Saussurea involucrata culture, inulin, oligosaccharide, vitamin and mineral in raw material components.
2. alimentation composition as claimed in claim 1, it is characterised in that be made up of the raw material of following weight portion: marine fish oligopeptide 20～40 parts, bone collagen peptide 10～30 parts, organic calcium 1～5 parts, phosphopeptide caseinate 1～5 parts, Saussurea involucrata culture 0.1～1 part, shark cartilage powder 1～5 parts, inulin 5～20 parts, oligosaccharide 5～30 parts, vitamin 0.1～1 part, mineral 1～3 parts.
3. alimentation composition as claimed in claim 2, it is characterised in that described marine fish oligopeptide is extracted by bathypelagic fish, and molecular weight is at below 1000Da.
4. alimentation composition as claimed in claim 2, it is characterised in that described bone collagen peptide is the activity polypeptid substance extracted from animal bone.
5. alimentation composition as claimed in claim 2, it is characterised in that described organic calcium is one or more mixing in calcium gluconate, calcium lactate, calcium citrate, calcium acetate.
6. alimentation composition as claimed in claim 2, it is characterised in that described Saussurea involucrata culture is wild Herba Saussureae Involueratae callus artificial culture's thing.
7. alimentation composition as claimed in claim 2, it is characterised in that a kind of chondroitin sulfate that described shark cartilage powder is made up of shark cartilage and the complex of protein.
8. alimentation composition as claimed in claim 2, it is characterised in that described oligosaccharide is one or more mixing in oligomeric isomaltose, oligofructose, soybean oligo saccharide, oligomeric xylose.
9. alimentation composition as claimed in claim 2, it is characterized in that, described vitamin comprises one or more mixing in vitamin A, vitamin D, vitamin E, vitamin K, vitamin C, vitamin B1, vitamin B2, vitamin B6, vitamin B12, nicotinic acid, folic acid, pantothenic acid, choline, biotin.
10. alimentation composition as claimed in claim 2, it is characterised in that described mineral comprises one or more mixing in calcium, phosphorus, potassium, sodium, magnesium, chlorine, ferrum, zinc, selenium, copper, manganese, iodine, fluorine, chromium, molybdenum.
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