CN104738638A - Composition with anti-fatigue effect and application thereof - Google Patents

Abstract

The invention relates to a composition with the anti-fatigue effect and application thereof, and specifically relates to a composition. The composition is prepared from the following active ingredients: maca, bioactive peptide and D-ribose, wherein maca is added to the composition by a mode of crushing raw plants into powder; or, the maca is added to the composition by the mode of extracting extracts of the raw plants; the composition, according to every 100 parts by weight of maca, is prepared from 1 to 10000 parts by weight of bioactive peptide, and 1 to 10000 parts by weight of D-ribose. The composition can be used for resisting fatigue and refreshing and has an outstanding biological effect.

Description

There is the composition and use thereof of antifatigue effect

Technical field

The invention belongs to health-oriented products field, relate to a kind of composition with antifatigue effect, and the purposes of said composition.Composition of the present invention can use as health product, health food, health drink or medical product.

Background technology

Agate coffee (Maca), have another name called agate card, Peruvian ginseng, maka, maca-maca, maino, ayak chichira, ayak willku etc., use the rhizome of its likeness in form radish sample hypertrophy, originate in the mountain area, Andean, South America of height above sea level 3500 ~ 4500 meters, mainly be distributed in the Puno ecotope in the middle part of Peru and Peru the southeastern city of Puno, for Cruciferae (Cruciferae) Lepidium (Lepidium) plant, Classification system Lepidiummeyenii.Also distribution is had on Chinese yunnan, Tibet, China, Bolivia and other places.

Agate coffee can be divided into black agate coffee, purple agate coffee and yellow agate coffee (comprising white agate coffee) according to product phase and epidermis color and luster.The wherein content of the core index such as agate coffee alkene, macamide, vitamin and amino acid, black agate coffee is significantly higher than purple agate coffee, and purple agate coffee is significantly higher than yellow agate coffee.Accordingly, the growth conditions of black agate coffee is the harshest, and output is also minimum, and purple agate coffee takes second place.Black agate coffee is most precious, and output generally accounts for 3%-5%; Purple agate coffee accounts for 10%-15%.

Agate coffee is the plateau plant of Cruciferae, originates in the plateau plant in more than 4000 meters, South America Peru Andes.Significant effect is had to balanced human's hormone secretion containing exclusive macamide and agate coffee alkene.Agate coffee has antifatigue, improves sperm quality, regains one's strength of body, improving water flood, anti-climacteric, and active fertility, strengthens the effects such as memory.And agate coffee is that men and women is suitable for, also there is good regulating action to the climacteric metancholia of women.

The required special natural environment and climate of agate coffee (MACA).It requires height above sea level more than 3500 meters, weather is special and soil is fertile, day and night the temperature difference reaches more than 40 degree, and such place is all rarely found in the whole world, only possesses such condition in the excessive area in the Yunnan-Guizhou Plateau and Qinghai-Tibet Platean of Andes, original producton location and China.The land area that global range can plant agate coffee is limited, and plant an agate coffee (MACA) in these limited soils after, the land requirement recuperation several years is in order to recover fertility, otherwise soil can not continue to cultivate.Although the U.S. and Japan successful introduction, but mainly based on scientific research, because agate coffee (MACA) growth conditions is very special and require that soil is fertile, the local whole world is like this all very rare, the place possessing this condition can not realize mechanized cultivation, so the global output of agate coffee is extremely low, the demand in the whole world substantially cannot be met.The cultivated area that the U.S. and Japan introduce a fine variety is little, and the agate coffee (MACA) that wherein content of effective ingredient is more original than Peru is low, and on labour costs, also exceeds tens times than Peru, so expensive.But the U.S. and Japan are to agate coffee demand all very greatly, so remain maximum Ma Ka importer so far.

Agate coffee has obtained the relevant authentication of each Main Developed Countries in the world as health food, and base comprises the FDA of the U.S..Moreover, agate coffee (MACA) also food and agricultural organization of united state (FAO) is listed among catalogue, that one of edible safety food is recommended by food and agricultural organization of united state, in order to improve people's malnutrition, nutrition unbalanced (life good do not represent balanced in nutrition), improve human body immune function and to improve fecundity (sexuality) and completely without any toxic and side effect.Be that a kind of colloidal state needs to grow in rich soil with other common agricultural unlike, agate coffee (MACA), in final-period management process, other fertilizer can not be applied.Under the specific condition of height above sea level more than 4000 meters, it is almost life forbidden zone, do not need to use chemical agent desinsection, because Foliage Absorption is very capable, also cannot use chemical agent weeding, plantation overall process uses manually completely, and in this unfrequented place, also do not have other industrial pollution, therefore this is a kind of real natural nuisance-free pollution-free food.In addition, agate coffee (MACA) has been eaten several thousand by local resident in Peru, never the clinical manifestation of addicted or pharmacological dependence, so edible agate coffee (MACA) or agate coffee product are safe.High mountain economic plants research institute of Chinese yunnan Shanxi Academy of Agricultural Sciences started in Yulong Mountain Yunnan height above sea level more than 3000 meters region successful introduction in 2003, planting technology is comparatively ripe, cultivated area progressively expands, be with at Lijiang, yunnan Yulong Xueshan one, Huize, yunnan, the ground such as Shangri-la starts to produce agate coffee, now realized scale plantation.Main producing region is distributed in the ground such as Yulong Mountain Yunnan, and its quality can compare favourably with Peru's agate coffee quality.

Fresh agate coffee (MACA) moisture content 10.4%, protein 10.2%, fat 2.2%, carbohydrate 59%, fiber 8.5%, ash content 4.9%.Amino acid containing abundant needed by human, as: arginine (9.94%), asparatate (9.17%), glutamic acid (15.6%) and lysine (54.5%) etc.In the aliphatic acid of agate coffee (MACA), the content of unrighted acid accounts for 52.7% (its Linoleic acid 18.5%, leukotrienes 8.87%), containing glucosinolate (glucosinolates) sterol and potassium, calcium, iron etc.Agate coffee alkene (macaenes) and macamide (mecamides) are contained in agate coffee (MACA) lipid position, also comprise N-benzyl caprylamide, N-benzyl-16-hydroxyl-9-oxidation-10E, 12E, 14E-pungent certain herbaceous plants with big flowers triolefin acid amides, N-benzyl-16 hydroxyl-9,16-dioxy-10E, the homologue of 12E, 14E-pungent certain herbaceous plants with big flowers triolefin acid amides and other 17 agate coffee alkene and macamide.Agate coffee alkene and macamide are considered to one of active principle of tool promotion property function in agate coffee (MACA) extract.

Agate coffee is rich in vigor nutrient, amino acid, vitamin and several mineral materials, also containing secondary metabolites and multiple bioactive ingredients such as alkaloid, glucosinolate, sterols, agate coffee reducing blood lipid, regulate endocrine, enhancement wish, the treatment of sexual dysfunction, antifatigue, anti-oxidant, improve climacteric metancholia, antitumor, treat in anaemia etc. there is good effect, to balanced human's diet nutritional, strengthen immune system and improve inferior health and have extraordinary effect.

D-ribose (D-ribose), molecular formula C5H10O5, being five important carbon monose, is the important composition material of ribonucleic acid (RNA), ATP, is formed with important function to life.D-ribose is also important pharmaceutical intermediate, for the production of multiple nucleic acids class medicine, and has broad application prospects.D-ribose is also called the crisp ribose of D-, different in nature gum sugar, D-ribose, D (-)-karyon sugar, D (-)-ribose, ribose, different gum sugar etc.No. CAS: the 50-69-1, molecular formula C5H10O5 of D-ribose, molecular weight 150.13.

D-ribose in white crystalline powder, has the sweet taste of refrigerant mouthfeel at normal temperatures; Fusing point: 88-92 DEG C; Water soluble, easily absorbs the moisture in air.It is quite safe that D-ribose is used as medical material, health products, intermediate, food additives etc.

D-ribose is the monose containing five carbon atoms, is epochmaking aldopentose, has α type and β type, and the large form mainly with pentosan or glucosides exists in vivo.

D-ribose is inhereditary material in organism--the important composition material of ribonucleic acid (RNA), is in hub site in nucleosides material, protein, fat metabolism, has important physiological function and wide application prospect.D-ribose, as the natural components be present in organism in all cells, has substantial connection with the formation of adenylate and the regeneration of atriphos (ATP), is one of the most basic energy source of vital metabolic.Play a crucial role in heart and the metabolism of bone network flesh, the recovery of ischemic tissue, ischaemia tissue can be promoted.

Nucleic acid drug is the important means of mankind nowadays treatment virus, tumour, AIDS, D-ribose is the important intermediate of many nucleic acid drugs, can be used in the production of many medicines such as ribavirin, adenosine, thymidine, cytidine, flurouracil nucleosides, 2-methyladenosine, prestige he toxin, pyrazoles toxin, adenosine dawn propylhomoserin.

The speed of the heart of human body and skeletal muscle synthesis ATP itself is slow, and D-ribose can accelerate the synthesis of ATP in heart and skeletal muscle, and therefore, heart and skeletal muscle are the Organ and tissues needing most D-ribose.One of magical effect of D-ribose: improve heart ischemia, promote cardiac function.Specifically, heart ischemia can make heart function decline, arrhythmia cordis.Research confirms; oral D-ribose can promote the generation of cardiac muscle cell ATP; make the function of cardiac muscle cell normal; thus obviously improve heart function; heart during protection ischemic; also have protective effect to the arrhythmia cordis of bringing out because of heart ischemia, make original once dynamic breathing heavily, often symptom that is nervous, uncomfortable in chest, the deficiency of vital energy be able to obvious improvement, quality of life improves greatly.Magical effect two of D-ribose: strengthen human body energy, alleviate DOMS.Specifically, people feels that tired immediate cause is the ATP generation deficiency of muscle cell, and make the energy shortage of muscle activity, people just has sense of fatigue.D-ribose is the starting molecule of synthesis ATP, and it is the important source material of muscle synthesis energy matter ATP.Research confirms, supplementary D-ribose can improve the locomitivity of human body, effective antifatigue, alleviates DOMS.

Three large production capacity nutrient sugar of human body, fat, protein can synthesize ATP in cell, but generally, sugar is the primary raw material of synthesis ATP.Sugar synthesis ATP wherein has a kind of mode, and glucose, through a series of chemical reaction, first produces ribose 5-phosphate, and regeneration purine nucleotides, finally generates ATP, provides energy to cell.This process is complicated, and reaction speed is slow.In each organ, the speed that glucose generates adenylic acid and ATP is different.Research finds, what speed was the highest is kidney, is secondly liver, and the speed of heart and skeletal muscle is minimum.This illustrates, the ability of heart and skeletal muscle synthesis ATP is lower than kidney and liver, and that is, ATP synthesis deficiency holds easily vulnerable tissue most or organ is heart and skeletal muscle.The elderly often suffers from atherosclerotic, and because of hemadostewnosis, thrombosis, each organ is easily in ischemic state.Under ischemic state, the ATP in cardiac muscle and Skeletal Muscle Cell can a large amount of decomposition, needs to supplement in time, the speed that cardiac muscle and skeletal muscle synthesize ATP because of itself is slow, can not supplement in time, the function reduction of heart and muscle, just there will be uncomfortable in chest, nervous, the phenomenon such as weakness of limbs, fatigue.If heart is in the state of ATP deficiency for a long time, final heart will " be gone on strike ", and people knows from experience because of in heart failure dead.

D-ribose, through intestinal absorption, with blood by after cardiac muscle cell and Skeletal Muscle Cell picked-up, under the effect of ribokinase, adds that the phosphate group produced after ATP decomposes directly generates ribose 5-phosphate, then generates ATP fast.Oral D-ribose, by this reaction path, can make the ribose 5-phosphate Fast back-projection algorithm in cardiac muscle and Skeletal Muscle Cell, then promote the reparation of adenylic acid, generate ATP fast.Glucose forms ribose 5-phosphate process complexity, speed is slow, and it is simple that D-ribose forms ribose 5-phosphate process, and speed is fast.D-ribose forms this approach of ribose 5-phosphate and compensate for cardiac muscle cell and the supplementary defect slowly of Skeletal Muscle Cell ATP, and when body experience anoxic, ischemic or high-intensity exercise, its effect is more outstanding.Research display: in some meat fibers, ATP regeneration needs 24 ~ 96 hours (1 ~ 4 day) completely, and human body could be recovered completely from overexercise.After supplementing D-ribose, can make approximately fast 3 ~ 4 times of the generating rate of ATP, that is, the recovery that ATP stores can reduce to 6 ~ 24 hours from 1 ~ 4 day.

Active peptide (Active Peptide) is well-known in the art.Peptide is the compound that two or more amino acid is connected with peptide bond, plays important physiological action in human body, plays physiological function.The polypeptide with BA is called active peptide, also known as biologically active peptide or biologically active polypeptide.

Active peptide is the general name (such as but not limited to Soybean Peptide, sea cucumber peptide etc., they are the part Typical Representatives in active peptide) of more than 1,000 kind of peptide.Its growing people, metabolism, disease and aging, play key effect in dead process.Active peptide is most important active material in human body.Exactly because it is the increasing or reduce of secretory volume in vivo, just make the mankind have childhood, childhood, grown up, old until the cycle of death.

Property peptide reduce have anything to affect on human body? the growth of active peptide major control human body, growth, immunological regulation and metabolism, it is in a kind of poised state at human body, if after active peptide reduces, the function generation important change of human body, for children, his growth, growth become slow, even stop, going down for a long time and just define dwarf, to adult or the elderly, after lacking active peptide, the immunity of self will decline, metabolic disturbance, endocrinopathy, the generation given rise to diseases, as insomnia, lean body mass or edema.Because active peptide also acts on nervous system, therefore human body will become slow movement, and brains is no longer wise, and more importantly active peptide reduces, and directly causes each position of the person to engender comprehensive aging, causes various disease.The extracting method of common peptide class mainly contains two kinds, and one is chemical reaction flows, and one is that Physical extracts.The two cuts both ways, and chemical leaching test is enzyme reaction extraction method mainly.Its reaction is fast, and output is large, but shortcoming to be the peptide class activity that extracts lower, this method is the main source of peptide series products on the market; Physics extraction method mainly refers to dielectric capacitance method active peptide extractive technique, and be characterized in that reaction is slow, output is little, but the peptide class produced has very high activity.

At present, active peptide has become the focus of whole world research, a large amount of domestic and international results of study shows: biologically active peptide relates to the bioactivator of various kinds of cell function in organism, find hundreds of kind in vivo, as the effect such as antiviral, anticancer, antithrombotic, anti-hypertension, immunological regulation, hormone control, antibacterial, norcholesterol.

The physiological function of active peptide common are: the moisture in control agent, electrolyte balance; For immune system manufacture is to the antibody of antibacterium and infection, improve immunologic function; Promote wound healing; Manufacture ferment in vivo, contributing to food conversion is energy; Repair cell, improves cellular metabolism, prevents cell degeneration, can play the effect of anti-cancer; Promote synthesis and the regulation and control of protein, enzyme, ferment; Link up the important chemical messenger of information between iuntercellular, organ; Prevention cardiovascular and cerebrovascular disease; Regulate endocrine and nervous system; Improve digestive system, treatment Chronic gastrointestinal diseases; Improve the diseases such as diabetes, rheumatism, rheumatoid disease; Viral infection resisting, anti-ageing, eliminate free radical unnecessary in body; Promote hematopoiesis function, treatment anaemia, prevents platelet aggregation, can improve the oxygen carrying capability of erythrocyte; Facedown DNA virus, has targeting to virus and bacteria.

The classification of active peptide can divide by raw material sources and health care.The classification divided by raw material has:

Breast peptide: obtain primarily of animal Ruzhong casein and lactalbumin enzymolysis, more more soluble than former albumen in water and digested, and acidproof, heat-resisting, permeate and force down, be have the call in active peptide, most widely used health food material;

Soybean Peptide: obtained by hydrolysate of soybean protein.There is low antigenicity, suppress cholesterol, promote the function such as lipid-metabolism and fermentation.Protein source can be supplemented fast, dispelling fatigue and as Bifidobacterium MF for food;

Corn peptide: obtained by zein enzymolysis.There is antifatigue, improve the function of liver, kidney, gastrointestinal disease patient nutrition, and can alcohol metabolism be promoted, be used as sobering food;

Pea peptide: enzymolysis pea protein obtains.Taste is gentle, inexpensive, can be used for infant formula;

White of an egg peptide: be also called protein peptides is obtained by enzymolysis egg protein.There is absorption easy to digest, low antigen, the feature such as heat-resisting, can be used in fluid food, nutraceutical or cake;

Livestock products peptide: obtained through enzymolysis by the albumen in livestock muscle, internal organ, blood, as de-fatted beef enzymolysis obtains beef peptide, containing comparatively high branched-chain amino acid and carnitine, is protein supplements low in calories; Fresh liver refines to obtain liver peptide through enzymolysis, decolouring, deodorization, ultrafiltration, can make short iron absorbent, for baby food, beverage, cake etc.; Pig blood obtains hyperglobulinemia peptide through enzymolysis, can be used for varieties of food items;

Aquatic peptide: the peptide that various fish protein enzymolysis is obtained, as sardine peptide, is angiotensin converting enzyme-inhibiting peptide, not containing bitter taste, can be used for making the hypertensive health food of control or preparation; Typical aquatic peptide has oyster peptide, sea cucumber peptide etc.;

Silk-fibroin peptide: the low peptide that silk cocoon silk-fibroin obtains through enzymolysis, has several functions such as promoting alcohol metabolism, reduction cholesterol, prevention dementia, can be used for sobering food and special health food;

Complex peptides: the complex peptides that the multiple proteins mixtures such as animals and plants, aquatic products, livestock products obtain through enzymolysis, has and improves lipid-metabolism function, can be used for all kinds of health food;

Absorption peptide easy to digest is had: the mainly low peptide such as dipeptides, tripeptides by the classification of active peptide health care, absorb fast than amino acid digestion, absorptivity is high, and there is low antigenicity, Hyposmolality, the bad reaction such as allergy, diarrhoea can not be caused, be applicable to the nourishing food of stomach hypofunction, Patients With Digestive Tract Diseases post-operative recovery, endurance sportsman, infant and old man.

Improve greatly although the living standard of modern society people is existing, because a variety of causes such as operating pressure is large etc., usually can cause the physical fatigue of people or lassitude etc.Therefore, for people provide a kind of health-oriented products that can be used for antifatigue, refresh oneself, be still that those skilled in the art extremely expect.

Summary of the invention

The object of the present invention is to provide a kind of composition with antifatigue, stimulating effect, expect said composition have at least one aspect such as of the present invention and the excellent properties of at least one aspect.The present invention have been surprisingly found that, the composition with prescription feature of the present invention has obtained the character of at least one above-mentioned aspect.The present invention is based on this find and be accomplished.

For this reason, first aspect present invention provides a kind of composition, and it is made by comprising following active material: agate coffee, active peptide and D-ribose.

In arbitrary embodiment of either side of the present invention, when using agate coffee, if not otherwise indicated, its dry product is all referred to.Certainly, when indicating, also its fresh goods can be used.No matter but be use fresh goods or dry product, when calculating its amount or relative quantity, be all in dry product.In arbitrary embodiment of either side of the present invention, the various active materials used, no matter they feed intake in what manner, when measuring, are all calculate with the dry product of these active materials.

The composition of arbitrary embodiment according to a first aspect of the present invention, wherein said agate coffee is that the form being broken into powder with its former Plant Powder is added in described composition; Or described agate coffee adds in described composition through extracting extract obtained form with its former plant.In one embodiment, the extract of described agate coffee is its water extract or ethanol extract (also can be described as alcohol extract or alcohol extract in the present invention, such as 10 ~ 90% ethanol extracts).The preparation technology of term " water extract " or " alcohol extract " well known to a person skilled in the art, namely processes 1-5 time in a heated condition for Extraction solvent at the described water of use or ethanol, each 0.5 ~ 5 hour, gets extract, concentrated, is drying to obtain.

The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of active peptide is 1 ~ 10000 weight portion.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of active peptide is 1 ~ 7500 weight portion.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of active peptide is 1 ~ 5000 weight portion.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of active peptide is 1 ~ 2000 weight portion.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of active peptide is 1 ~ 1000 weight portion.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of active peptide is 1 ~ 750 weight portion.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of active peptide is 1 ~ 500 weight portion.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of active peptide is 1 ~ 400 weight portion.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of active peptide is 1 ~ 300 weight portion.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of active peptide is 1 ~ 200 weight portion.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of active peptide is 1 ~ 100 weight portion.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of active peptide is 1 ~ 75 weight portion.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of active peptide is 1 ~ 50 weight portion.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of active peptide is 1 ~ 25 weight portion.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of active peptide is 1 ~ 20 weight portion.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of active peptide is 1 ~ 15 weight portion.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of active peptide is 1 ~ 10 weight portion.

The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of active peptide is 10 ~ 10000 weight portions.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of active peptide is 15 ~ 10000 weight portions.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of active peptide is 20 ~ 10000 weight portions.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of active peptide is 25 ~ 10000 weight portions.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of active peptide is 50 ~ 10000 weight portions.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of active peptide is 75 ~ 10000 weight portions.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of active peptide is 100 ~ 10000 weight portions.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of active peptide is 200 ~ 10000 weight portions.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of active peptide is 300 ~ 10000 weight portions.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of active peptide is 400 ~ 10000 weight portions.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of active peptide is 500 ~ 10000 weight portions.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of active peptide is 750 ~ 10000 weight portions.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of active peptide is 1000 ~ 10000 weight portions.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of active peptide is 2000 ~ 10000 weight portions.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of active peptide is 5000 ~ 10000 weight portions.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of active peptide is 7500 ~ 10000 weight portions.

The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of active peptide is 5 ~ 7500 weight portions.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of active peptide is 10 ~ 5000 weight portions.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of active peptide is 15 ~ 2000 weight portions.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of active peptide is 20 ~ 1000 weight portions.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of active peptide is 25 ~ 750 weight portions.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of active peptide is 30 ~ 500 weight portions.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of active peptide is 35 ~ 400 weight portions.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of active peptide is 40 ~ 300 weight portions.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of active peptide is 45 ~ 200 weight portions.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of active peptide is 50 ~ 150 weight portions.

The composition of arbitrary embodiment according to a first aspect of the present invention, wherein said active peptide is selected from: ocean fish-skin peptide, Soybean Peptide, oyster peptide, corn peptide, wheat peptide, rice peptide, pea peptide, protein peptides and sea cucumber peptide.These active peptides are that those skilled in the art are easily obtained, and they all can easily be buied from the market, such as Soybean Peptide can purchased from Wei Wei food company, and oyster peptide can purchased from Zhengzhou Qi Huadun company, and corn peptide is purchased from Beijing Zhong Shi Hai Shi company etc.

The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of D-ribose is 1 ~ 10000 weight portion.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of D-ribose is 1 ~ 7500 weight portion.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of D-ribose is 1 ~ 5000 weight portion.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of D-ribose is 1 ~ 2000 weight portion.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of D-ribose is 1 ~ 1000 weight portion.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of D-ribose is 1 ~ 750 weight portion.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of D-ribose is 1 ~ 500 weight portion.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of D-ribose is 1 ~ 400 weight portion.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of D-ribose is 1 ~ 300 weight portion.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of D-ribose is 1 ~ 200 weight portion.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of D-ribose is 1 ~ 100 weight portion.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of D-ribose is 1 ~ 75 weight portion.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of D-ribose is 1 ~ 50 weight portion.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of D-ribose is 1 ~ 25 weight portion.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of D-ribose is 1 ~ 20 weight portion.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of D-ribose is 1 ~ 15 weight portion.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of D-ribose is 1 ~ 10 weight portion.

The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of D-ribose is 10 ~ 10000 weight portions.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of D-ribose is 15 ~ 10000 weight portions.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of D-ribose is 20 ~ 10000 weight portions.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of D-ribose is 25 ~ 10000 weight portions.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of D-ribose is 50 ~ 10000 weight portions.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of D-ribose is 75 ~ 10000 weight portions.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of D-ribose is 100 ~ 10000 weight portions.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of D-ribose is 200 ~ 10000 weight portions.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of D-ribose is 300 ~ 10000 weight portions.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of D-ribose is 400 ~ 10000 weight portions.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of D-ribose is 500 ~ 10000 weight portions.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of D-ribose is 750 ~ 10000 weight portions.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of D-ribose is 1000 ~ 10000 weight portions.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of D-ribose is 2000 ~ 10000 weight portions.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of D-ribose is 5000 ~ 10000 weight portions.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of D-ribose is 7500 ~ 10000 weight portions.

The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of D-ribose is 5 ~ 7500 weight portions.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of D-ribose is 10 ~ 5000 weight portions.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of D-ribose is 15 ~ 2000 weight portions.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of D-ribose is 20 ~ 1000 weight portions.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of D-ribose is 25 ~ 750 weight portions.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of D-ribose is 30 ~ 500 weight portions.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of D-ribose is 35 ~ 400 weight portions.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of D-ribose is 40 ~ 300 weight portions.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of D-ribose is 45 ~ 200 weight portions.The composition of arbitrary embodiment according to a first aspect of the present invention, wherein in the agate coffee of every 100 weight portions, the amount of D-ribose is 50 ~ 150 weight portions.

Have been found that making agate coffee and active peptide combine obtained product has excellent antifatigue and the effect of refreshing oneself; But when the two Long-Time Service, there will be the ill-effect of the smooth or even constipation of defecation.The present inventor has been surprisingly found that, when adding appropriate D-ribose again in the composition particularly comprising both above-mentioned agate coffee and active peptide in the compositions of the present invention, highly advantageously can overcome the above-mentioned ill-effect to human body.

According to the composition of the arbitrary embodiment of either side of the present invention, it is the formulation used in suitable for oral administration.Described formulation is such as but not limited to: vina, beverage (such as cold tea), tablet, capsule, paste (such as with brown sugar, donkey-hide gelatin, the curvature of the spinal column for matrix), solid beverage (such as electuary, pulvis etc.) etc.Preparing these formulations is that this area such as field of food or pharmaceutical field technical staff are known.And when preparing these formulations, usually can also add on food or pharmaceutically acceptable adjuvant.

According to the composition of the arbitrary embodiment of either side of the present invention, wherein also comprise on food or pharmaceutically acceptable adjuvant.Term " adjuvant " refers to and to add to composition be made suitable product form, and does not usually have physiological functional activity.Notoriously, the adjuvant kind that different product forms is selected is likely different.Such as vina, its main adjuvant is wine, comprises various forms of beverage wine, such as white wine, yellow rice wine or foreign wine; Now, the amount of described active material total amount in this vina can be 1 ~ 50%, such as 1 ~ 40%, such as 1 ~ 30%, such as 1 ~ 20%, such as 1 ~ 10% usually.Such as beverage, its main adjuvant is water; Now, described active material total amount amount in the beverage can be 1 ~ 50%, such as 1 ~ 40%, such as 1 ~ 30%, such as 1 ~ 20%, such as 1 ~ 10% usually.Such as tablet, diluent, disintegrant, adhesive, lubricant that pharmacy is commonly used can optionally add.The contribution of the present invention to present technology is to find agate coffee and active peptide and D-ribose to combine, effect when have been surprisingly found that being used alone far above them not only appears in this combination in antifatigue with the effect of refreshing oneself, also finds that this combination can overcome the harmful effect to health of the other side occurred when both agate coffee and active peptide combine separately.That is, the present invention to the contribution of prior art be not depend on these adjuvants existence whether (although when they are present in the present composition be favourable for the convenience orally used).Therefore, essence of the present invention is to find that above-mentioned agate coffee and active peptide and D-ribose combine.

Further, second aspect present invention provides composition described in the arbitrary embodiment of first aspect present invention for the preparation of the purposes in antifatigue and/or the product of refreshing oneself.

Purposes according to a second aspect of the present invention, wherein said composition is in antifatigue and/or avoid composition to produce harmful effect (such as defecation smooth or even constipation) to health while refreshing oneself.Particularly, described composition is in antifatigue and/or avoid both agate coffee and active peptide to combinationally use while refreshing oneself producing harmful effect (such as defecation smooth or even constipation) to health.

Further, third aspect present invention provides agate coffee, active peptide and D-ribose three and is combined in for the preparation of the purposes in antifatigue and/or the product of refreshing oneself, and described product is in antifatigue and/or avoid composition to produce harmful effect (such as defecation smooth or even constipation) to health while refreshing oneself.Particularly, described product is in antifatigue and/or avoid both agate coffee and active peptide to combinationally use while refreshing oneself producing harmful effect (such as defecation smooth or even constipation) to health.

The purposes of arbitrary embodiment according to a third aspect of the present invention, wherein said agate coffee is that the form being broken into powder with its former Plant Powder is added in described composition; Or described agate coffee adds in described composition through extracting extract obtained form with its former plant.In one embodiment, the extract of described agate coffee is its water extract or ethanol extract (also can be described as alcohol extract or alcohol extract in the present invention, such as 10 ~ 90% ethanol extracts).The preparation technology of term " water extract " or " alcohol extract " well known to a person skilled in the art, namely processes 1-5 time in a heated condition for Extraction solvent at the described water of use or ethanol, each 0.5 ~ 5 hour, gets extract, concentrated, is drying to obtain.

The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of active peptide is 1 ~ 10000 weight portion.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of active peptide is 1 ~ 7500 weight portion.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of active peptide is 1 ~ 5000 weight portion.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of active peptide is 1 ~ 2000 weight portion.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of active peptide is 1 ~ 1000 weight portion.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of active peptide is 1 ~ 750 weight portion.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of active peptide is 1 ~ 500 weight portion.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of active peptide is 1 ~ 400 weight portion.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of active peptide is 1 ~ 300 weight portion.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of active peptide is 1 ~ 200 weight portion.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of active peptide is 1 ~ 100 weight portion.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of active peptide is 1 ~ 75 weight portion.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of active peptide is 1 ~ 50 weight portion.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of active peptide is 1 ~ 25 weight portion.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of active peptide is 1 ~ 20 weight portion.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of active peptide is 1 ~ 15 weight portion.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of active peptide is 1 ~ 10 weight portion.

The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of active peptide is 10 ~ 10000 weight portions.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of active peptide is 15 ~ 10000 weight portions.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of active peptide is 20 ~ 10000 weight portions.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of active peptide is 25 ~ 10000 weight portions.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of active peptide is 50 ~ 10000 weight portions.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of active peptide is 75 ~ 10000 weight portions.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of active peptide is 100 ~ 10000 weight portions.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of active peptide is 200 ~ 10000 weight portions.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of active peptide is 300 ~ 10000 weight portions.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of active peptide is 400 ~ 10000 weight portions.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of active peptide is 500 ~ 10000 weight portions.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of active peptide is 750 ~ 10000 weight portions.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of active peptide is 1000 ~ 10000 weight portions.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of active peptide is 2000 ~ 10000 weight portions.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of active peptide is 5000 ~ 10000 weight portions.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of active peptide is 7500 ~ 10000 weight portions.

The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of active peptide is 5 ~ 7500 weight portions.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of active peptide is 10 ~ 5000 weight portions.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of active peptide is 15 ~ 2000 weight portions.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of active peptide is 20 ~ 1000 weight portions.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of active peptide is 25 ~ 750 weight portions.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of active peptide is 30 ~ 500 weight portions.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of active peptide is 35 ~ 400 weight portions.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of active peptide is 40 ~ 300 weight portions.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of active peptide is 45 ~ 200 weight portions.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of active peptide is 50 ~ 150 weight portions.

The purposes of arbitrary embodiment according to a third aspect of the present invention, wherein said active peptide is selected from: ocean fish-skin peptide, Soybean Peptide, oyster peptide, corn peptide, wheat peptide, rice peptide, pea peptide, protein peptides and sea cucumber peptide.These active peptides are that those skilled in the art are easily obtained, and they all can easily be buied from the market, such as Soybean Peptide can purchased from Wei Wei food company, and oyster peptide can purchased from Zhengzhou Qi Huadun company, and corn peptide is purchased from Beijing Zhong Shi Hai Shi company etc.

The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of D-ribose is 1 ~ 10000 weight portion.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of D-ribose is 1 ~ 7500 weight portion.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of D-ribose is 1 ~ 5000 weight portion.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of D-ribose is 1 ~ 2000 weight portion.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of D-ribose is 1 ~ 1000 weight portion.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of D-ribose is 1 ~ 750 weight portion.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of D-ribose is 1 ~ 500 weight portion.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of D-ribose is 1 ~ 400 weight portion.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of D-ribose is 1 ~ 300 weight portion.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of D-ribose is 1 ~ 200 weight portion.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of D-ribose is 1 ~ 100 weight portion.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of D-ribose is 1 ~ 75 weight portion.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of D-ribose is 1 ~ 50 weight portion.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of D-ribose is 1 ~ 25 weight portion.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of D-ribose is 1 ~ 20 weight portion.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of D-ribose is 1 ~ 15 weight portion.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of D-ribose is 1 ~ 10 weight portion.

The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of D-ribose is 10 ~ 10000 weight portions.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of D-ribose is 15 ~ 10000 weight portions.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of D-ribose is 20 ~ 10000 weight portions.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of D-ribose is 25 ~ 10000 weight portions.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of D-ribose is 50 ~ 10000 weight portions.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of D-ribose is 75 ~ 10000 weight portions.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of D-ribose is 100 ~ 10000 weight portions.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of D-ribose is 200 ~ 10000 weight portions.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of D-ribose is 300 ~ 10000 weight portions.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of D-ribose is 400 ~ 10000 weight portions.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of D-ribose is 500 ~ 10000 weight portions.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of D-ribose is 750 ~ 10000 weight portions.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of D-ribose is 1000 ~ 10000 weight portions.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of D-ribose is 2000 ~ 10000 weight portions.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of D-ribose is 5000 ~ 10000 weight portions.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of D-ribose is 7500 ~ 10000 weight portions.

The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of D-ribose is 5 ~ 7500 weight portions.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of D-ribose is 10 ~ 5000 weight portions.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of D-ribose is 15 ~ 2000 weight portions.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of D-ribose is 20 ~ 1000 weight portions.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of D-ribose is 25 ~ 750 weight portions.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of D-ribose is 30 ~ 500 weight portions.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of D-ribose is 35 ~ 400 weight portions.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of D-ribose is 40 ~ 300 weight portions.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of D-ribose is 45 ~ 200 weight portions.The purposes of arbitrary embodiment according to a third aspect of the present invention, in the agate coffee of every 100 weight portions in wherein said product, the amount of D-ribose is 50 ~ 150 weight portions.

The purposes of arbitrary embodiment according to a third aspect of the present invention, wherein said product is the formulation used in suitable for oral administration.Described formulation is such as but not limited to: vina, beverage (such as cold tea), tablet, capsule, paste (such as with brown sugar, donkey-hide gelatin, the curvature of the spinal column for matrix), solid beverage (such as electuary, pulvis etc.) etc.Preparing these formulations is that this area such as field of food or pharmaceutical field technical staff are known.And when preparing these formulations, usually can also add on food or pharmaceutically acceptable adjuvant.

The purposes of arbitrary embodiment according to a third aspect of the present invention, also comprises on food or pharmaceutically acceptable adjuvant in wherein said product.Term " adjuvant " refers to and to add to composition be made suitable product form, and does not usually have physiological functional activity.Notoriously, the adjuvant kind that different product forms is selected is likely different.Such as vina, its main adjuvant is wine, comprises various forms of beverage wine, such as white wine, yellow rice wine or foreign wine; Now, the amount of described active material total amount in this vina can be 1 ~ 50%, such as 1 ~ 40%, such as 1 ~ 30%, such as 1 ~ 20%, such as 1 ~ 10% usually.Such as beverage, its main adjuvant is water; Now, described active material total amount amount in the beverage can be 1 ~ 50%, such as 1 ~ 40%, such as 1 ~ 30%, such as 1 ~ 20%, such as 1 ~ 10% usually.Such as tablet, diluent, disintegrant, adhesive, lubricant that pharmacy is commonly used can optionally add.The contribution of the present invention to present technology is to find agate coffee and active peptide and D-ribose to combine, effect when have been surprisingly found that being used alone far above them not only appears in this combination in antifatigue with the effect of refreshing oneself, also finds that this combination can overcome the harmful effect to health of the other side occurred when both agate coffee and active peptide combine separately.That is, the present invention to the contribution of prior art be not depend on these adjuvants existence whether (although when they are present in the present composition be favourable for the convenience orally used).Therefore, essence of the present invention is to find that above-mentioned agate coffee and active peptide and D-ribose combine.

Detailed description of the invention

The following examples provided only for task of explanation instead of for, should not be interpreted as limiting the present invention by any way yet.Those skilled in the art will recognize that can make routine to following examples when not surmounting the spirit or scope of the present invention changes and amendment.

In instantiation below, if not otherwise specified, the agate coffee used is that dry product is through powder pulverized powder.

In instantiation below, if not otherwise specified, the agate coffee water extract used is that agate coffee water extracts 3 times in a heated condition, each 1 hour, gets extract, concentrated, the extract of dry gained; The agate coffee ethanol extract used is that agate coffee 70% ethanol extracts 3 times in a heated condition, each 1 hour, gets extract, concentrated, the extract of dry gained.No matter feeding intake in what manner, when measuring, is all calculate with the dry product of these active substance of plant.In instantiation below, if not otherwise specified, the various active peptides used are commercially available products.

In the following embodiments, if not otherwise indicated, when each material represents with weight portion, composition amount of preparation counts 100g/ batch with agate coffee inventory.In the following embodiments, if not otherwise indicated, when feeding intake, each material is ground into the powder by 80 mesh sieves all in advance.

one, composition preparation example part

Embodiment 1: prepared by composition

Formula: agate coffee 100 weight portion, active peptide (Soybean Peptide) 1 weight portion, D-ribose 10000 weight portion.Method for making: the powder of each material is mixed, to obtain final product.

Embodiment 2: prepared by composition

Formula: agate coffee 100 weight portion, active peptide (Soybean Peptide) 10000 weight portion, D-ribose 1 weight portion.Method for making: the powder of each material is mixed, to obtain final product.

Embodiment 3: prepared by composition

Formula: agate coffee 100 weight portion, active peptide (Soybean Peptide) 1 weight portion, D-ribose 1 weight portion.Method for making: the powder of each material is mixed, to obtain final product.

Embodiment 4: prepared by composition

Formula: agate coffee 100 weight portion, active peptide (Soybean Peptide) 10000 weight portion, D-ribose 10000 weight portion.Method for making: the powder of each material is mixed, to obtain final product.

Embodiment 5: prepared by composition

Formula: agate coffee 100 weight portion, active peptide (Soybean Peptide) 7500 weight portion, D-ribose 1000 weight portion.Method for making: the powder of each material is mixed, to obtain final product.

Embodiment 6: prepared by composition

Formula: agate coffee 100 weight portion, active peptide (Soybean Peptide) 1000 weight portion, D-ribose 7500 weight portion.Method for making: the powder of each material is mixed, to obtain final product.

Embodiment 7: prepared by composition

Formula: agate coffee 100 weight portion, active peptide (Soybean Peptide) 750 weight portion, D-ribose 5000 weight portion.Method for making: the powder of each material is mixed, to obtain final product.

Embodiment 8: prepared by composition

Formula: agate coffee 100 weight portion, active peptide (Soybean Peptide) 5000 weight portion, D-ribose 750 weight portion.Method for making: the powder of each material is mixed, to obtain final product.

Embodiment 9: prepared by composition

Formula: agate coffee 100 weight portion, active peptide (pea peptide) 500 weight portions, D-ribose 2000 weight portion.Method for making: the powder of each material is mixed, to obtain final product.

Embodiment 10: prepared by composition

Formula: agate coffee 100 weight portion, active peptide (Soybean Peptide) 2000 weight portion, D-ribose 500 weight portion.Method for making: the powder of each material is mixed, to obtain final product.

Embodiment 11: prepared by composition

Formula: agate coffee 100 weight portion, active peptide (Soybean Peptide) 1000 weight portion, D-ribose 400 weight portion.Method for making: the powder of each material is mixed, to obtain final product.

Embodiment 12: prepared by composition

Formula: agate coffee 100 weight portion, active peptide (ocean fish-skin peptide) 400 weight portions, D-ribose 1000 weight portion.Method for making: the powder of each material is mixed, to obtain final product.

Embodiment 13: prepared by composition

Formula: agate coffee 100 weight portion, active peptide (Soybean Peptide) 300 weight portion, D-ribose 75 weight portion.Method for making: the powder of each material is mixed, to obtain final product.

Embodiment 14: prepared by composition

Formula: agate coffee 100 weight portion, active peptide (Soybean Peptide) 75 weight portion, D-ribose 300 weight portion.Method for making: the powder of each material is mixed, to obtain final product.

Embodiment 15: prepared by composition

Formula: agate coffee 100 weight portion, active peptide (corn peptide) 200 weight portion, D-ribose 50 weight portion.Method for making: the powder of each material is mixed, to obtain final product.

Embodiment 16: prepared by composition

Formula: agate coffee 100 weight portion, active peptide (wheat peptide) 50 weight portion, D-ribose 200 weight portion.Method for making: the powder of each material is mixed, to obtain final product.

Embodiment 17: prepared by composition

Formula: agate coffee 100 weight portion, active peptide (Soybean Peptide) 100 weight portion, D-ribose 25 weight portion.Method for making: the powder of each material is mixed, to obtain final product.

Embodiment 18: prepared by composition

Formula: agate coffee 100 weight portion, active peptide (rice peptide) 25 weight portion, D-ribose 100 weight portion.Method for making: the powder of each material is mixed, to obtain final product.

Embodiment 19: prepared by composition

Formula: agate coffee 100 weight portion, active peptide (protein peptides) 20 weight portion, D-ribose 15 weight portion.Method for making: the powder of each material is mixed, to obtain final product.

Embodiment 20: prepared by composition

Formula: agate coffee 100 weight portion, active peptide (Soybean Peptide) 15 weight portion, D-ribose 10 weight portion.Method for making: the powder of each material is mixed, to obtain final product.

Embodiment 21: prepared by composition

Formula: agate coffee 100 weight portion, active peptide (Soybean Peptide) 10 weight portion, D-ribose 5 weight portion.Method for making: the powder of each material is mixed, to obtain final product.

Embodiment 22: prepared by composition

Formula: agate coffee 100 weight portion, active peptide (sea cucumber peptide) 5 weight portion, D-ribose 20 weight portion.Method for making: the powder of each material is mixed, to obtain final product.

Embodiment 23: prepared by composition

Formula: agate coffee 100 weight portion, active peptide (Soybean Peptide) 35 weight portion, D-ribose 30 weight portion.Method for making: the powder of each material is mixed, to obtain final product.

Embodiment 24: prepared by composition

Formula: agate coffee 100 weight portion, active peptide (Soybean Peptide) 45 weight portion, D-ribose 35 weight portion.Method for making: the powder of each material is mixed, to obtain final product.

Embodiment 25: prepared by composition

Formula: agate coffee 100 weight portion, active peptide (Soybean Peptide) 30 weight portion, D-ribose 40 weight portion.Method for making: the powder of each material is mixed, to obtain final product.

Embodiment 26: prepared by composition

Formula: agate coffee 100 weight portion, active peptide (Soybean Peptide) 40 weight portion, D-ribose 45 weight portion.Method for making: the powder of each material is mixed, to obtain final product.

Embodiment 27: prepared by composition

Formula: agate coffee 100 weight portion, active peptide (oyster peptide) 100 weight portion, D-ribose 100 weight portion.Method for making: the powder of each material is mixed, to obtain final product.

Embodiment 28: prepared by composition

Formula: agate coffee water extract 100 weight portion, active peptide (oyster peptide) 20 weight portion, D-ribose 500 weight portion.Method for making: the powder of each material is mixed, to obtain final product.

Embodiment 29: prepared by composition

Formula: agate coffee alcohol extract 100 weight portion, active peptide (corn peptide) 500 weight portion, D-ribose 20 weight portion.Method for making: the powder of each material is mixed, to obtain final product.

Embodiment 30: prepared by composition

Agate coffee alcohol extract 100 weight portion, active peptide (Soybean Peptide) 200 weight portion, D-ribose 50 weight portion, 45% degree of white wine of additional 2000 weight portions, makes vina by the method for making of vina.

Embodiment 31: prepared by composition

Agate coffee water extract 100 weight portion, active peptide (corn peptide) 50 weight portion, D-ribose 250 weight portion, the water of additional 8000 weight portions, makes beverage by well-established law.

Embodiment 32: prepared by composition

Agate coffee 100 weight portion, active peptide (pea peptide) 50 weight portions, D-ribose 250 weight portion, additional 100 weight starch, 50 weight portion dextrin, make mixed-powder by well-established law, encapsulated, become capsule, and every contains agate coffee in medicinal material 0.1g.

Embodiment 33: prepared by composition

Agate coffee alcohol extract 100 weight portion, active peptide (oyster peptide) 50 weight portion, D-ribose 150 weight portion, additional 150 weight starch, 150 weight portion dextrin, be wetting agent softwood with water, granulate, dry, adding particle weight 0.5% dolomol is lubricant, mix, be pressed into tablet by well-established law, every sheet contains agate coffee in medicinal material 0.2g.

Reference examples 1: prepared by composition

The formula of reference example 27 and method for making, different is only do not add active peptide.

Reference examples 2: prepared by composition

The formula of reference example 27 and method for making, different is only do not add D-ribose.

Two, the biological property of composition is investigated

Use the method for evaluation product anti-fatigue effect classical clinically below, investigate the embodiment of the present invention 9, embodiment 10, embodiment 15, embodiment 16, embodiment 27, embodiment 28, embodiment 29, reference examples 1, (nine dosage are 2.5g/ days in agate coffee to reference examples 2 nine kinds of compositions, once a day, be used in conjunction 2 weeks), (dosage is 5g/ days to agate coffee, once a day, be used in conjunction 2 weeks), (dosage is 10g/ days to Soybean Peptide, once a day, be used in conjunction 2 weeks), (dosage is 5g/ days to D-ribose, once a day, be used in conjunction 2 weeks) anti-fatigue effect.

Adopt the method for completely random packet design, gesticulate sequence lower than the experimenter of 3 points by surname by table 1 state of mind criteria scores by 120, by random digits table, experimenter is divided into 12 groups, uses one of above 12 kinds of products respectively.

Table 1: state of mind standards of grading

The state of mind describes	Score
		Energetic	7-10
The state of mind is good	4-7
		Sleepy tired out	0-4

In the 15th day time, the standards of grading of use table 1 evaluate the state of mind of each group of experimenter, and to its marking, calculate the scoring mean value often organized.In addition, the defecation situation (defecation sensation is given a mark with three kinds of standard meters to heavy generally with light: defecation smooth and easy (0-4 divides), defecation smooth (4-7 divides), constipation (7-10 divides)) of each experimenter is recorded.Result: reference examples 1, reference examples 2 respectively organize the state of mind score of experimenter all within the scope of 5.1 ~ 6.7 points, reference examples 2 groups of defecation scores 8.6 points, reference examples 1 group of defecation score 2.4 points; The state of mind score of agate coffee group experimenter 4.8 points, defecation score is all at 2.2 points; The state of mind score of Soybean Peptide group experimenter 3.1 points, defecation score is all at 9.1 points; The state of mind score of D-ribose group experimenter 3.9 points, defecation score is all at 1.8 points; Embodiment 9, embodiment 10, embodiment 15, embodiment 16, embodiment 27, embodiment 28, embodiment 29 respectively organize the state of mind score of experimenter all within the scope of 8.2 ~ 9.4 points, defecation score, all within the scope of 0.3 ~ 1.8 point, illustrates that these products present the anti-fatigue effect that makes us being satisfied with very much and do not occur bad reaction.

In addition, in extra complementary testing, use said method, investigate and calculate in foregoing embodiments 1-32 without these " two, the biological property of composition investigate " investigate and for 100 weight portion agate coffees the state of mind score of active peptide and those compositions of D-ribose consumption all within the scope of 10-5000 weight portion and defecation score, result shows the state of mind score of these compositions all within the scope of 8.1 ~ 9.2 points, and defecation score is all within the scope of 0.4 ~ 2.1 point.

In addition, find in extra complementary testing, on the basis of the present composition, add other material again, no matter be that there is the medicinal of BA or edible materials, or do not have an adjuvant of BA, all do not affect above the biological performance of the present composition described in " two, the biological property of composition investigate ", namely the present invention finds by the impact whether other material adds.

Industrial applicability

The invention provides a kind of have superior bio active composition, particularly said composition there is the excellent efficacy of antifatigue and Long-Time Service not to the bad reaction of health.

Although present invention has been description to a certain degree, significantly, under the condition not departing from the spirit and scope of the present invention, can carry out the suitable change of each condition.Be appreciated that and the invention is not restricted to described embodiment, and be attributed to the scope of claim, it comprises the equivalent replacement of described each factor.

Claims (10)

1. a composition, it is made by comprising following active material: agate coffee, active peptide and D-ribose.

2. composition according to claim 1, wherein said agate coffee is that the form being broken into powder with its former Plant Powder is added in described composition; Or described agate coffee adds in described composition with its former plant through extracting extract obtained form; In one embodiment, the extract of described agate coffee is its water extract or ethanol extract.

3. composition according to claim 1, wherein in the agate coffee of every 100 weight portions, the amount of active peptide is 1 ~ 10000 weight portion; Such as 1 ~ 7500 weight portion; Such as 1 ~ 5000 weight portion; Such as 1 ~ 2000 weight portion; Such as 1 ~ 1000 weight portion; Such as 1 ~ 750 weight portion; Such as 1 ~ 500 weight portion; Such as 1 ~ 400 weight portion; Such as 1 ~ 300 weight portion; Such as 1 ~ 200 weight portion; Such as 1 ~ 100 weight portion; Such as 1 ~ 75 weight portion; Such as 1 ~ 50 weight portion; Such as 1 ~ 25 weight portion; Such as 1 ~ 20 weight portion; Such as 1 ~ 15 weight portion; Such as 1 ~ 10 weight portion; Or

Wherein in the agate coffee of every 100 weight portions, the amount of active peptide is 10 ~ 10000 weight portions; Such as 15 ~ 10000 weight portions; Such as 20 ~ 10000 weight portions; Such as 25 ~ 10000 weight portions; Such as 50 ~ 10000 weight portions; Such as 75 ~ 10000 weight portions; Such as 100 ~ 10000 weight portions; Such as 200 ~ 10000 weight portions; Such as 300 ~ 10000 weight portions; Such as 400 ~ 10000 weight portions; Such as 500 ~ 10000 weight portions; Such as 750 ~ 10000 weight portions; Such as 1000 ~ 10000 weight portions; Such as 2000 ~ 10000 weight portions; Such as 5000 ~ 10000 weight portions; Such as 7500 ~ 10000 weight portions; Or

Wherein in the agate coffee of every 100 weight portions, the amount of active peptide is 5 ~ 7500 weight portions; Such as 10 ~ 5000 weight portions; Such as 15 ~ 2000 weight portions; Such as 20 ~ 1000 weight portions; Such as 25 ~ 750 weight portions; Such as 30 ~ 500 weight portions; Such as 35 ~ 400 weight portions; Such as 40 ~ 300 weight portions; Such as 45 ~ 200 weight portions; Such as 50 ~ 150 weight portions.

4. composition according to claim 1, wherein said active peptide is selected from: ocean fish-skin peptide, Soybean Peptide, oyster peptide, corn peptide, wheat peptide, rice peptide, pea peptide, protein peptides and sea cucumber peptide.

5. composition according to claim 1, wherein in the agate coffee of every 100 weight portions, the amount of D-ribose is 1 ~ 10000 weight portion; Such as 1 ~ 7500 weight portion; Such as 1 ~ 5000 weight portion; Such as 1 ~ 2000 weight portion; Such as 1 ~ 1000 weight portion; Such as 1 ~ 750 weight portion; Such as 1 ~ 500 weight portion; Such as 1 ~ 400 weight portion; Such as 1 ~ 300 weight portion; Such as 1 ~ 200 weight portion; Such as 1 ~ 100 weight portion; Such as 1 ~ 75 weight portion; Such as 1 ~ 50 weight portion; Such as 1 ~ 25 weight portion; Such as 1 ~ 20 weight portion; Such as 1 ~ 15 weight portion; Such as 1 ~ 10 weight portion; Or

Wherein in the agate coffee of every 100 weight portions, the amount of D-ribose is 10 ~ 10000 weight portions; Such as 15 ~ 10000 weight portions; Such as 20 ~ 10000 weight portions; Such as 25 ~ 10000 weight portions; Such as 50 ~ 10000 weight portions; Such as 75 ~ 10000 weight portions; Such as 100 ~ 10000 weight portions; Such as 200 ~ 10000 weight portions; Such as 300 ~ 10000 weight portions; Such as 400 ~ 10000 weight portions; Such as 500 ~ 10000 weight portions; Such as 750 ~ 10000 weight portions; Such as 1000 ~ 10000 weight portions; Such as 2000 ~ 10000 weight portions; Such as 5000 ~ 10000 weight portions; Such as 7500 ~ 10000 weight portions; Or

Wherein in the agate coffee of every 100 weight portions, the amount of D-ribose is 5 ~ 7500 weight portions; Such as 10 ~ 5000 weight portions; Such as 15 ~ 2000 weight portions; Such as 20 ~ 1000 weight portions; Such as 25 ~ 750 weight portions; Such as 30 ~ 500 weight portions; Such as 35 ~ 400 weight portions; Such as 40 ~ 300 weight portions; Such as 45 ~ 200 weight portions; Such as 50 ~ 150 weight portions.

6. composition according to claim 1, it is the formulation used in suitable for oral administration; Further, described formulation is such as but not limited to: vina, beverage (such as cold tea), tablet, capsule, paste (such as with brown sugar, donkey-hide gelatin, the curvature of the spinal column for matrix), solid beverage (such as electuary, pulvis etc.) etc.; Further, also comprise on food in described composition or pharmaceutically acceptable adjuvant.

7. composition described in any one of claim 1-6 is for the preparation of the purposes in antifatigue and/or the product of refreshing oneself; Further, described composition is in antifatigue and/or avoid composition to produce harmful effect to health while refreshing oneself; Further, described composition is in antifatigue and/or avoid both agate coffee and active peptide to combinationally use while refreshing oneself producing harmful effect to health.

8. agate coffee, active peptide and D-ribose three are combined in for the preparation of the purposes in antifatigue and/or the product of refreshing oneself, and described product is in antifatigue and/or avoid composition to produce harmful effect to health while refreshing oneself; Further, described product is in antifatigue and/or avoid both agate coffee and active peptide to combinationally use while refreshing oneself producing harmful effect to health.

9. purposes according to claim 8, wherein said agate coffee is that the form being broken into powder with its former Plant Powder is added in described composition; Or described agate coffee adds in described composition with its former plant through extracting extract obtained form; Or, also comprise on food in described product or pharmaceutically acceptable adjuvant; Such as, the extract of described agate coffee is its water extract or ethanol extract; Or described active peptide is selected from: ocean fish-skin peptide, Soybean Peptide, oyster peptide, corn peptide, wheat peptide, rice peptide, pea peptide, protein peptides and sea cucumber peptide; Or described product is the formulation used in suitable for oral administration; Further, described formulation is such as but not limited to: vina, beverage (such as cold tea), tablet, capsule, paste (such as with brown sugar, donkey-hide gelatin, the curvature of the spinal column for matrix), solid beverage (such as electuary, pulvis etc.).

10. purposes according to claim 8, in the agate coffee of every 100 weight portions in wherein said product, the amount of active peptide is 1 ~ 10000 weight portion; Such as 1 ~ 7500 weight portion; Such as 1 ~ 5000 weight portion; Such as 1 ~ 2000 weight portion; Such as 1 ~ 1000 weight portion; Such as 1 ~ 750 weight portion; Such as 1 ~ 500 weight portion; Such as 1 ~ 400 weight portion; Such as 1 ~ 300 weight portion; Such as 1 ~ 200 weight portion; Such as 1 ~ 100 weight portion; Such as 1 ~ 75 weight portion; Such as 1 ~ 50 weight portion; Such as 1 ~ 25 weight portion; Such as 1 ~ 20 weight portion; Such as 1 ~ 15 weight portion; Such as 1 ~ 10 weight portion; Or

In the agate coffee of every 100 weight portions in wherein said product, the amount of active peptide is 10 ~ 10000 weight portions; Such as 15 ~ 10000 weight portions; Such as 20 ~ 10000 weight portions; Such as 25 ~ 10000 weight portions; Such as 50 ~ 10000 weight portions; Such as 75 ~ 10000 weight portions; Such as 100 ~ 10000 weight portions; Such as 200 ~ 10000 weight portions; Such as 300 ~ 10000 weight portions; Such as 400 ~ 10000 weight portions; Such as 500 ~ 10000 weight portions; Such as 750 ~ 10000 weight portions; Such as 1000 ~ 10000 weight portions; Such as 2000 ~ 10000 weight portions; Such as 5000 ~ 10000 weight portions; Such as 7500 ~ 10000 weight portions; Or

In the agate coffee of every 100 weight portions in wherein said product, the amount of active peptide is 5 ~ 7500 weight portions; Such as 10 ~ 5000 weight portions; Such as 15 ~ 2000 weight portions; Such as 20 ~ 1000 weight portions; Such as 25 ~ 750 weight portions; Such as 30 ~ 500 weight portions; Such as 35 ~ 400 weight portions; Such as 40 ~ 300 weight portions; Such as 45 ~ 200 weight portions; Such as 50 ~ 150 weight portions; Or

In the agate coffee of every 100 weight portions in wherein said product, the amount of D-ribose is 1 ~ 10000 weight portion; Such as 1 ~ 7500 weight portion; Such as 1 ~ 5000 weight portion; Such as 1 ~ 2000 weight portion; Such as 1 ~ 1000 weight portion; Such as 1 ~ 750 weight portion; Such as 1 ~ 500 weight portion; Such as 1 ~ 400 weight portion; Such as 1 ~ 300 weight portion; Such as 1 ~ 200 weight portion; Such as 1 ~ 100 weight portion; Such as 1 ~ 75 weight portion; Such as 1 ~ 50 weight portion; Such as 1 ~ 25 weight portion; Such as 1 ~ 20 weight portion; Such as 1 ~ 15 weight portion; Such as 1 ~ 10 weight portion; Or

In the agate coffee of every 100 weight portions in wherein said product, the amount of D-ribose is 10 ~ 10000 weight portions; Such as 15 ~ 10000 weight portions; Such as 20 ~ 10000 weight portions; Such as 25 ~ 10000 weight portions; Such as 50 ~ 10000 weight portions; Such as 75 ~ 10000 weight portions; Such as 100 ~ 10000 weight portions; Such as 200 ~ 10000 weight portions; Such as 300 ~ 10000 weight portions; Such as 400 ~ 10000 weight portions; Such as 500 ~ 10000 weight portions; Such as 750 ~ 10000 weight portions; Such as 1000 ~ 10000 weight portions; Such as 2000 ~ 10000 weight portions; Such as 5000 ~ 10000 weight portions; Such as 7500 ~ 10000 weight portions; Or

In the agate coffee of every 100 weight portions in wherein said product, the amount of D-ribose is 5 ~ 7500 weight portions; Such as 10 ~ 5000 weight portions; Such as 15 ~ 2000 weight portions; Such as 20 ~ 1000 weight portions; Such as 25 ~ 750 weight portions; Such as 30 ~ 500 weight portions; Such as 35 ~ 400 weight portions; Such as 40 ~ 300 weight portions; Such as 45 ~ 200 weight portions; Such as 50 ~ 150 weight portions.