CN115474692A - Nutritional composition for conditioning female endocrine function - Google Patents
Nutritional composition for conditioning female endocrine function Download PDFInfo
- Publication number
- CN115474692A CN115474692A CN202110667192.1A CN202110667192A CN115474692A CN 115474692 A CN115474692 A CN 115474692A CN 202110667192 A CN202110667192 A CN 202110667192A CN 115474692 A CN115474692 A CN 115474692A
- Authority
- CN
- China
- Prior art keywords
- parts
- peptide
- nutritional composition
- endocrine function
- powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 235000016709 nutrition Nutrition 0.000 title claims abstract description 28
- 230000003750 conditioning effect Effects 0.000 title claims abstract description 27
- 230000007368 endocrine function Effects 0.000 title claims abstract description 27
- 239000000203 mixture Substances 0.000 title claims abstract description 26
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 48
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 26
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 26
- 235000008434 ginseng Nutrition 0.000 claims abstract description 26
- 241000251511 Holothuroidea Species 0.000 claims abstract description 21
- 240000000759 Lepidium meyenii Species 0.000 claims abstract description 19
- 235000000421 Lepidium meyenii Nutrition 0.000 claims abstract description 19
- 235000012902 lepidium meyenii Nutrition 0.000 claims abstract description 19
- 241000237502 Ostreidae Species 0.000 claims abstract description 12
- 235000020636 oyster Nutrition 0.000 claims abstract description 12
- 108010010803 Gelatin Proteins 0.000 claims abstract description 11
- 229920000159 gelatin Polymers 0.000 claims abstract description 11
- 239000008273 gelatin Substances 0.000 claims abstract description 11
- 235000019322 gelatine Nutrition 0.000 claims abstract description 11
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 11
- PYMYPHUHKUWMLA-LMVFSUKVSA-N aldehydo-D-ribose Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 claims abstract description 9
- 229940041514 candida albicans extract Drugs 0.000 claims abstract description 9
- 239000012138 yeast extract Substances 0.000 claims abstract description 9
- 239000002994 raw material Substances 0.000 claims abstract description 8
- JBYXPOFIGCOSSB-GOJKSUSPSA-N 9-cis,11-trans-octadecadienoic acid Chemical compound CCCCCC\C=C\C=C/CCCCCCCC(O)=O JBYXPOFIGCOSSB-GOJKSUSPSA-N 0.000 claims abstract description 7
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 claims abstract description 7
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 claims abstract description 7
- 229940108924 conjugated linoleic acid Drugs 0.000 claims abstract description 7
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 claims abstract description 7
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims abstract description 6
- 239000000600 sorbitol Substances 0.000 claims abstract description 6
- 239000000843 powder Substances 0.000 claims description 30
- 241000208340 Araliaceae Species 0.000 claims description 25
- 238000010438 heat treatment Methods 0.000 claims description 18
- 102000004190 Enzymes Human genes 0.000 claims description 14
- 108090000790 Enzymes Proteins 0.000 claims description 14
- 229940088598 enzyme Drugs 0.000 claims description 14
- 239000004365 Protease Substances 0.000 claims description 12
- 230000000415 inactivating effect Effects 0.000 claims description 12
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 9
- 108091005804 Peptidases Proteins 0.000 claims description 9
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims description 9
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 9
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims description 9
- 238000004140 cleaning Methods 0.000 claims description 9
- 150000001875 compounds Chemical class 0.000 claims description 9
- 235000019419 proteases Nutrition 0.000 claims description 9
- 239000006228 supernatant Substances 0.000 claims description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 7
- 238000000643 oven drying Methods 0.000 claims description 7
- 238000002360 preparation method Methods 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 238000001816 cooling Methods 0.000 claims description 6
- 239000000284 extract Substances 0.000 claims description 6
- 238000007873 sieving Methods 0.000 claims description 6
- 239000003153 chemical reaction reagent Substances 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 5
- 238000010298 pulverizing process Methods 0.000 claims description 5
- 108010052008 colla corii asini Proteins 0.000 claims description 4
- 239000004382 Amylase Substances 0.000 claims description 3
- 108010065511 Amylases Proteins 0.000 claims description 3
- 102000013142 Amylases Human genes 0.000 claims description 3
- 108091005658 Basic proteases Proteins 0.000 claims description 3
- 108090000526 Papain Proteins 0.000 claims description 3
- 108010059820 Polygalacturonase Proteins 0.000 claims description 3
- 102000004142 Trypsin Human genes 0.000 claims description 3
- 108090000631 Trypsin Proteins 0.000 claims description 3
- 235000019418 amylase Nutrition 0.000 claims description 3
- 238000010411 cooking Methods 0.000 claims description 3
- 239000008367 deionised water Substances 0.000 claims description 3
- 229910021641 deionized water Inorganic materials 0.000 claims description 3
- 239000012153 distilled water Substances 0.000 claims description 3
- 108010093305 exopolygalacturonase Proteins 0.000 claims description 3
- 238000005360 mashing Methods 0.000 claims description 3
- 239000012528 membrane Substances 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 229940055729 papain Drugs 0.000 claims description 3
- 235000019834 papain Nutrition 0.000 claims description 3
- 238000010992 reflux Methods 0.000 claims description 3
- 238000001694 spray drying Methods 0.000 claims description 3
- 239000012588 trypsin Substances 0.000 claims description 3
- 238000000108 ultra-filtration Methods 0.000 claims description 3
- 239000003480 eluent Substances 0.000 claims description 2
- 238000004108 freeze drying Methods 0.000 claims description 2
- 238000010025 steaming Methods 0.000 claims description 2
- 208000017701 Endocrine disease Diseases 0.000 abstract description 2
- 230000035558 fertility Effects 0.000 abstract description 2
- 230000036541 health Effects 0.000 abstract description 2
- 230000001568 sexual effect Effects 0.000 abstract description 2
- 244000131316 Panax pseudoginseng Species 0.000 abstract 1
- 208000030172 endocrine system disease Diseases 0.000 abstract 1
- HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 description 6
- 239000005556 hormone Substances 0.000 description 5
- 229940088597 hormone Drugs 0.000 description 5
- 229940011871 estrogen Drugs 0.000 description 4
- 239000000262 estrogen Substances 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 230000004060 metabolic process Effects 0.000 description 3
- 210000001672 ovary Anatomy 0.000 description 3
- 201000004384 Alopecia Diseases 0.000 description 2
- 206010003694 Atrophy Diseases 0.000 description 2
- 208000021663 Female sexual arousal disease Diseases 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 208000037093 Menstruation Disturbances Diseases 0.000 description 2
- 206010027339 Menstruation irregular Diseases 0.000 description 2
- 206010033165 Ovarian failure Diseases 0.000 description 2
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 2
- 208000006262 Psychological Sexual Dysfunctions Diseases 0.000 description 2
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 2
- 231100000360 alopecia Toxicity 0.000 description 2
- 230000037444 atrophy Effects 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 210000000750 endocrine system Anatomy 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 206010022437 insomnia Diseases 0.000 description 2
- 208000010125 myocardial infarction Diseases 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 201000004535 ovarian dysfunction Diseases 0.000 description 2
- 231100000539 ovarian failure Toxicity 0.000 description 2
- 230000001766 physiological effect Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 208000005189 Embolism Diseases 0.000 description 1
- 206010014733 Endometrial cancer Diseases 0.000 description 1
- 206010014759 Endometrial neoplasm Diseases 0.000 description 1
- 201000009273 Endometriosis Diseases 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 208000033830 Hot Flashes Diseases 0.000 description 1
- 206010060800 Hot flush Diseases 0.000 description 1
- 201000001431 Hyperuricemia Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- 206010057071 Rectal tenesmus Diseases 0.000 description 1
- 206010062237 Renal impairment Diseases 0.000 description 1
- 206010041591 Spinal osteoarthritis Diseases 0.000 description 1
- 208000001435 Thromboembolism Diseases 0.000 description 1
- 206010046543 Urinary incontinence Diseases 0.000 description 1
- 206010046788 Uterine haemorrhage Diseases 0.000 description 1
- 206010046798 Uterine leiomyoma Diseases 0.000 description 1
- 206010046910 Vaginal haemorrhage Diseases 0.000 description 1
- 206010047791 Vulvovaginal dryness Diseases 0.000 description 1
- 206010000059 abdominal discomfort Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 210000000577 adipose tissue Anatomy 0.000 description 1
- 210000004100 adrenal gland Anatomy 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 208000022531 anorexia Diseases 0.000 description 1
- 230000000489 anti-atherogenic effect Effects 0.000 description 1
- 230000003178 anti-diabetic effect Effects 0.000 description 1
- 239000003472 antidiabetic agent Substances 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 210000003403 autonomic nervous system Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000001217 buttock Anatomy 0.000 description 1
- 210000000748 cardiovascular system Anatomy 0.000 description 1
- 208000036319 cervical spondylosis Diseases 0.000 description 1
- 239000005515 coenzyme Substances 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 210000003372 endocrine gland Anatomy 0.000 description 1
- 230000002357 endometrial effect Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 238000002657 hormone replacement therapy Methods 0.000 description 1
- 239000000413 hydrolysate Substances 0.000 description 1
- 210000003016 hypothalamus Anatomy 0.000 description 1
- 230000002519 immonomodulatory effect Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000001965 increasing effect Effects 0.000 description 1
- 208000000509 infertility Diseases 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 231100000535 infertility Toxicity 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 230000005977 kidney dysfunction Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 230000005976 liver dysfunction Effects 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 210000004914 menses Anatomy 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 230000036651 mood Effects 0.000 description 1
- 208000031225 myocardial ischemia Diseases 0.000 description 1
- 201000009240 nasopharyngitis Diseases 0.000 description 1
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 1
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 230000011164 ossification Effects 0.000 description 1
- 230000002611 ovarian Effects 0.000 description 1
- 230000016087 ovulation Effects 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 210000004560 pineal gland Anatomy 0.000 description 1
- 230000001817 pituitary effect Effects 0.000 description 1
- 239000000186 progesterone Substances 0.000 description 1
- 229960003387 progesterone Drugs 0.000 description 1
- 239000000583 progesterone congener Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 210000004994 reproductive system Anatomy 0.000 description 1
- 229920002477 rna polymer Polymers 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 208000012201 sexual and gender identity disease Diseases 0.000 description 1
- 230000035946 sexual desire Effects 0.000 description 1
- 208000015891 sexual disease Diseases 0.000 description 1
- 208000005801 spondylosis Diseases 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
- 208000012271 tenesmus Diseases 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/14—Yeasts or derivatives thereof
- A23L33/145—Extracts
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a nutritional composition for conditioning female endocrine function. The nutritional composition for conditioning the female endocrine function is prepared from the following raw materials in parts by weight: 15-20 parts of maca, 15-20 parts of D-ribose, 10-17 parts of conjugated linoleic acid, 5-7 parts of yeast extract, 5-7 parts of ginseng peptide, 5-15 parts of oyster peptide, 5-15 parts of sea cucumber peptide, 5-10 parts of donkey-hide gelatin peptide and 10-15 parts of sorbitol. The nutritional composition for conditioning the female endocrine function can be prepared into a health industrial nutritional product, improves the female sexual life quality and fertility by conditioning the female endocrine function, and quickly adjusts the female endocrine disorder.
Description
Technical Field
The invention relates to the technical field of nutritional compositions, in particular to a nutritional composition for conditioning female endocrine function.
Background
The endocrine system is involved in regulating many physiological activities and life phenomena of human body such as metabolic process, growth and development, reproductive aging and the like, and cooperates with various enzymes (biochemical enzymes) to maintain the relative stability of the internal environment of the human body so as to adapt to complicated and changeable in-vivo and in-vitro changes. The female ovary is an important organ for secreting estrogen and progestogen (or progesterone) and is the key to female endocrine metabolism. Ovarian failure can lead to the following diseases: the reproductive system: irregular menstruation, vaginal atrophy and dryness, low ovulation rate, sexual disorder, frigidity and the like; the autonomic nervous system: hot flashes, irritability, depression, insomnia, etc.; figure form: obesity, abdominal distension, buttock tenesmus, water bucket waist, etc.; skin, hair: dryness, loss of elasticity, etc., alopecia, and loss of luster; and (3) immunity reduction: is susceptible to common cold, inflammation or chronic diseases; cardiovascular system: atherosclerosis such as myocardial ischemia, myocardial infarction; urinary system atrophy, hyperuricemia, frequent micturition, urinary incontinence, etc.; bone: cervical spondylosis, rheumatism, arthritis, osteoporosis, etc.; a digestive system: stomach discomfort, anorexia, constipation, etc.
At present, the decline of ovarian function and the decrease of estrogen secretion can be slowed down and improved by the hormone supplementation. Such as hormone replacement therapy, but the potential risk of this form of treatment is not negligible, contraindications include history of estrogen-dependent tumors, such as endometrial and breast cancer women; women who have had or had thromboembolism, such as stroke, myocardial infarction; severe liver and kidney dysfunction, heart failure, severe diabetes accompanied by vasculopathy, hysteromyoma, endometriosis, vaginal bleeding of unknown origin, etc.
Disclosure of Invention
The invention aims to provide a nutritional composition for conditioning female endocrine function.
In order to solve the technical problems, the invention adopts the following technical scheme:
the nutritional composition for conditioning the female endocrine function is prepared from the following raw materials in parts by weight:
15-20 parts of maca, 15-20 parts of D-ribose, 10-17 parts of conjugated linoleic acid, 5-7 parts of yeast extract, 5-7 parts of ginseng peptide, 5-15 parts of oyster peptide, 5-15 parts of sea cucumber peptide, 5-10 parts of donkey-hide gelatin peptide and 10-15 parts of sorbitol.
Preferably, the maca contains 99.9% -99.99% macamide.
Further, the extraction method of the macamide comprises the following steps:
(1) Pulverizing dried maca root, sieving with 40-50 mesh sieve to obtain maca root powder;
(2) Taking 10-15g of maca root powder, adding 50-60ml of glycerol and 50-65ml of ethyl acetate, heating and refluxing at 45-50 ℃ for 8-10h to obtain a primary extract;
(3) Distilling the primary extract under reduced pressure to recover reagent, eluting with 30-35% ethanol through chromatographic column, and collecting eluate;
(4) Lyophilizing the eluate, and making into powder.
Preferably, the yeast used in the yeast extract is beer yeast or saccharomyces cerevisiae.
Preferably, the preparation method of the ginseng peptide comprises the following steps:
(1) Cleaning Ginseng radix, oven drying, pulverizing, and sieving with 300-400 mesh sieve to obtain Ginseng radix powder;
(2) Adding 100-150g of prepared ginseng powder into a preparation tank, adding 300-350ml of deionized water, adding 1-1.5g of papain, 0.5-1g of amylase, 0.5-1g of compound protease and 0.3-0.5g of pectinase, carrying out enzymolysis at 35-40 ℃ for 2-3h, then heating to 95-100 ℃, inactivating enzymes for 30-40min, cooling, centrifuging and taking supernatant to obtain enzymolysis liquid;
(3) Adjusting the pH value of the enzymolysis liquid to 7.0, and drying to obtain the ginseng peptide powder.
Further, the ginseng is artificially planted biological ginseng for less than five years.
Preferably, the preparation method of the oyster peptide comprises the following steps:
(1) Removing shell of Concha Ostreae, cleaning Carnis Ostreae, homogenizing, heating at 95-100 deg.C for 30-40min, and cooling;
(2) Taking 100-150g of homogenate tissue, adding 3-4g of compound protease for enzymolysis for 5-8h at 35-40 ℃, then heating to 90-95 ℃, and inactivating enzyme for 30-40min;
(3) Ultrafiltering the obtained enzymolysis solution with ultrafiltration membrane with molecular weight cutoff of 8-10kDa to obtain enzymolysis solution;
(4) Spray drying the enzymolysis solution to prepare powder to obtain oyster peptide powder.
Preferably, the preparation method of the sea cucumber peptide comprises the following steps:
(1) Cleaning the body wall of the sea cucumber and mashing the sea cucumber into sea cucumber homogenate;
(2) Taking 100-150g of homogenate tissue, adding 3-3.5g of compound protease, carrying out enzymolysis for 2-3h at 40-45 ℃, then heating to 95-100 ℃, and inactivating enzyme for 30-40min; centrifuging to obtain supernatant to obtain enzymolysis solution;
(3) Adjusting the pH value of the enzymolysis liquid to 7.0-7.5, and drying to obtain the sea cucumber peptide powder.
Preferably, the preparation method of the donkey-hide gelatin peptide comprises the following steps:
(1) Taking the donkey-hide gelatin blocks, adding distilled water, and steaming and boiling for 5-6h at 90-100 ℃;
(2) Taking 100-150g of cooking liquor, adding 2-3g of alkaline protease and 0.5-1g of trypsin, carrying out enzymolysis for 5-6h at 40-50 ℃, then heating to 90-100 ℃, and inactivating enzyme for 30-40min; centrifuging to obtain supernatant to obtain enzymolysis solution;
(3) Adjusting pH of the enzymolysis solution to 7.0-7.5, and oven drying to obtain colla Corii Asini peptide powder.
Compared with the prior art, the invention has the beneficial technical effects that:
the nutritional composition for conditioning the female endocrine function can be prepared into health industrial nutritional products, improves the female sexual life quality and fertility by conditioning the female endocrine function, and quickly adjusts female endocrine disorders such as frigidity, vaginal dryness, irregular menstruation, infertility, insomnia, alopecia and the like.
Detailed Description
The following examples are given to illustrate specific embodiments of the present invention, but are not intended to limit the scope of the present invention in any way.
The raw materials and reagents used in the following examples are, unless otherwise specified, all conventional raw materials and reagents, and all commercially available products.
Example 1: nutritional composition for conditioning female endocrine function
The nutritional composition for conditioning the female endocrine function consists of the following raw materials in parts by mass:
18 parts of maca, 15 parts of D-ribose, 10 parts of conjugated linoleic acid, 6 parts of yeast extract, 5 parts of ginseng peptide, 8 parts of oyster peptide, 10 parts of sea cucumber peptide, 10 parts of donkey-hide gelatin peptide and 15 parts of sorbitol.
Wherein maca contains 99.9% macaamide, acts on hypothalamus and pituitary, has effects in regulating secretion of hormone, balancing endocrine glands such as adrenal gland, thyroid gland, pancreas, ovary, testis, pineal body, etc., and stimulating hormone to restore balance under the action of minerals such as iron, copper, etc., and amino acids. Macamide breaks through the traditional problem that hyposecretion is supplemented by exogenous hormone, and the balance of an endocrine system and the body and mind is achieved again by exciting each organ in the body to secrete the required hormone automatically.
The extraction method of the macamide comprises the following steps:
(1) Taking dried maca roots, crushing and sieving the maca roots with a 50-mesh sieve to obtain maca root powder;
(2) Taking 10g maca root powder, adding 50ml of glycerol and 50ml of ethyl acetate, heating and refluxing at 45 ℃ for 10 hours to extract to obtain a primary extract;
(3) Distilling the primary extract under reduced pressure to recover reagent, eluting with 30% ethanol through chromatographic column, and collecting eluate;
(4) Freeze-drying the eluent, and making into powder.
Among them, D-ribose, also known as D-ribofuranose, is a component of ribonucleic acid, certain vitamins and nucleotide coenzymes (such as NAD, NADH, FAD, ADP, UDP, CDP, GDP, etc.) in organisms, and has very important physiological effects.
Among them, conjugated linoleic acid has anti-atherogenic, anti-diabetic, immunomodulating, growth promoting, body fat reducing and lean mass increasing effects and effects on bone formation.
Wherein the yeast used in the yeast extract is Saccharomyces cerevisiae or Saccharomyces cerevisiae.
The extraction method of the ginseng peptide comprises the following steps:
(1) Collecting biological Ginseng radix artificially planted for less than five years, cleaning Ginseng radix, oven drying, pulverizing, and sieving with 300 mesh sieve to obtain Ginseng radix powder;
(2) Adding 100g of the prepared ginseng powder into a preparation tank, adding 300ml of deionized water, adding 1g of papain, 0.5g of amylase, 0.5g of compound protease and 0.3g of pectinase, carrying out enzymolysis at 35 ℃ for 2h, then heating to 95 ℃, inactivating enzymes for 30min, cooling, centrifuging and taking supernatant to obtain enzymatic hydrolysate;
(3) Adjusting pH of the enzymolysis solution to 7.0, and oven drying to obtain Ginseng radix peptide powder.
The method for extracting the oyster peptide comprises the following steps:
(1) Removing shell of Concha Ostreae, cleaning Carnis Ostreae, homogenizing, heating at 100 deg.C for 30min, and cooling;
(2) Taking 100g of homogenate tissue, adding 4g of compound protease, performing enzymolysis for 5h at 40 ℃, then heating to 90 ℃, and inactivating enzyme for 30min;
(3) Ultrafiltering the obtained enzymolysis solution with ultrafiltration membrane with molecular weight cutoff of 8000Da to obtain enzymolysis solution;
(4) Spray drying the enzymolysis solution to prepare powder to obtain oyster peptide powder.
The extraction method of the sea cucumber peptide comprises the following steps:
(1) Cleaning the body wall of the sea cucumber and mashing the sea cucumber into sea cucumber homogenate;
(2) Taking 100g of homogenate tissue, adding 3g of compound protease, carrying out enzymolysis for 2h at 40 ℃, then heating to 95 ℃, and inactivating enzyme for 30min; centrifuging to obtain supernatant to obtain enzymolysis solution;
(3) Adjusting the pH value of the enzymolysis liquid to 7.0, and drying to obtain the sea cucumber peptide powder.
The method for extracting the donkey-hide gelatin peptide comprises the following steps:
(1) Decocting colla Corii Asini block with distilled water at 100 deg.C for 5 hr;
(2) Taking 100g of the cooking liquor, adding 2g of alkaline protease and 1g of trypsin, carrying out enzymolysis for 6h at 40 ℃, then heating to 100 ℃, and inactivating the enzyme for 30min; centrifuging to obtain supernatant to obtain enzymolysis solution;
(3) Adjusting the pH value of the enzymolysis liquid to 7.0, and drying to obtain the donkey-hide gelatin peptide powder.
The ovarian failure of women can be effectively improved by taking the nutritional composition for conditioning the endocrine function of women for about one month. The main manifestation is that the ovary can secrete sufficient estrogen to keep the skin moisture, promote the metabolism and blood circulation of the skin and make the skin tender, delicate, plump, moist and glossy; can maintain normal sexual desire, good mood and memory of female; disturbed menses becomes regular.
Example 2: nutritional composition for conditioning female endocrine function
The difference from example 1 is that:
the nutritional composition for conditioning the female endocrine function consists of the following raw materials in parts by mass:
15 parts of maca, 20 parts of D-ribose, 10 parts of conjugated linoleic acid, 5 parts of yeast extract, 7 parts of ginseng peptide, 15 parts of oyster peptide, 15 parts of sea cucumber peptide, 5 parts of donkey-hide gelatin peptide and 10 parts of sorbitol.
Example 3: nutritional composition for conditioning female endocrine function
The difference from example 1 is that:
the nutritional composition for conditioning the female endocrine function consists of the following raw materials in parts by mass:
20 parts of maca, 18 parts of D-ribose, 15 parts of conjugated linoleic acid, 7 parts of yeast extract, 6 parts of ginseng peptide, 10 parts of oyster peptide, 5 parts of sea cucumber peptide, 6 parts of donkey-hide gelatin peptide and 14 parts of sorbitol.
Although the present invention has been described in detail with reference to the embodiments, it will be understood by those skilled in the art that various changes in the specific parameters of the embodiments may be made without departing from the spirit of the present invention, and a plurality of specific embodiments are formed, which are common variations of the present invention, and will not be described in detail herein.
Claims (9)
1. The nutritional composition for conditioning the female endocrine function is characterized by being prepared from the following raw materials in parts by weight:
15-20 parts of maca, 15-20 parts of D-ribose, 10-17 parts of conjugated linoleic acid, 5-7 parts of yeast extract, 5-7 parts of ginseng peptide, 5-15 parts of oyster peptide, 5-15 parts of sea cucumber peptide, 5-10 parts of donkey-hide gelatin peptide and 10-15 parts of sorbitol.
2. The nutritional composition for conditioning female endocrine function according to claim 1, wherein said maca contains 99.9-99.99% macamides.
3. The nutritional composition for conditioning female endocrine function according to claim 2, wherein the macamide is extracted by the following method:
(1) Pulverizing dried maca root, sieving with 40-50 mesh sieve to obtain maca root powder;
(2) Taking 10-15g of maca root powder, adding 50-60ml of glycerol and 50-65ml of ethyl acetate, heating and refluxing at 45-50 ℃ for 8-10h to obtain a primary extract;
(3) Distilling the primary extract under reduced pressure to recover reagent, eluting with 30-35% ethanol through chromatographic column, and collecting eluate;
(4) Freeze-drying the eluent, and making into powder.
4. The nutritional composition for conditioning female endocrine function according to claim 1, wherein the yeast used in yeast extract is brewer's yeast or saccharomyces cerevisiae.
5. The nutritional composition for conditioning female endocrine function according to claim 1, wherein the ginseng peptide is prepared by the following steps:
(1) Cleaning Ginseng radix, oven drying, pulverizing, and sieving with 300-400 mesh sieve to obtain Ginseng radix powder;
(2) Adding 100-150g of prepared ginseng powder into a preparation tank, adding 300-350ml of deionized water, adding 1-1.5g of papain, 0.5-1g of amylase, 0.5-1g of compound protease and 0.3-0.5g of pectinase, carrying out enzymolysis for 2-3h at 35-40 ℃, then heating to 95-100 ℃, inactivating enzyme for 30-40min, cooling, centrifuging and taking supernatant to obtain enzymolysis liquid;
(3) Adjusting pH of the enzymolysis solution to 7.0, and oven drying to obtain Ginseng radix peptide powder.
6. The nutritional composition for conditioning female endocrine function according to claim 5, wherein said ginseng is a biological ginseng grown artificially for less than five years.
7. The nutritional composition for conditioning female endocrine function according to claim 1, wherein the oyster peptide is prepared by the following steps:
(1) Removing shell of Concha Ostreae, cleaning Carnis Ostreae, homogenizing, heating at 95-100 deg.C for 30-40min, and cooling;
(2) Taking 100-150g of homogenate tissue, adding 3-4g of compound protease for enzymolysis for 5-8h at 35-40 ℃, then heating to 90-95 ℃, and inactivating enzyme for 30-40min;
(3) Ultrafiltering the obtained enzymolysis solution with ultrafiltration membrane with molecular weight cutoff of 8-10kDa to obtain enzymolysis solution;
(4) Spray drying the enzymolysis solution to prepare powder to obtain oyster peptide powder.
8. The nutritional composition for conditioning female endocrine function according to claim 1, wherein the sea cucumber peptide is prepared by the following steps:
(1) Cleaning the body wall of the sea cucumber and mashing the sea cucumber into sea cucumber homogenate;
(2) Taking 100-150g of homogenate tissue, adding 3-3.5g of compound protease for enzymolysis for 2-3h at 40-45 ℃, then heating to 95-100 ℃, and inactivating enzyme for 30-40min; centrifuging to obtain supernatant to obtain enzymolysis solution;
(3) Adjusting the pH value of the enzymolysis liquid to 7.0-7.5, and drying to obtain the sea cucumber peptide powder.
9. The nutritional composition for conditioning female endocrine function according to claim 1, wherein the donkey-hide gelatin peptide is prepared by the following steps:
(1) Taking colla Corii Asini blocks, adding distilled water, and steaming at 90-100 deg.C for 5-6 hr;
(2) Taking 100-150g of cooking liquor, adding 2-3g of alkaline protease and 0.5-1g of trypsin, carrying out enzymolysis for 5-6h at 40-50 ℃, then heating to 90-100 ℃, and inactivating enzyme for 30-40min; centrifuging to obtain supernatant to obtain enzymolysis solution;
(3) Adjusting pH of the enzymolysis solution to 7.0-7.5, and oven drying to obtain colla Corii Asini peptide powder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110667192.1A CN115474692A (en) | 2021-06-16 | 2021-06-16 | Nutritional composition for conditioning female endocrine function |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110667192.1A CN115474692A (en) | 2021-06-16 | 2021-06-16 | Nutritional composition for conditioning female endocrine function |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115474692A true CN115474692A (en) | 2022-12-16 |
Family
ID=84418920
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110667192.1A Pending CN115474692A (en) | 2021-06-16 | 2021-06-16 | Nutritional composition for conditioning female endocrine function |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN115474692A (en) |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102021215A (en) * | 2010-11-11 | 2011-04-20 | 湖北远成药业有限公司 | Method for extracting gelatin peptides |
| CN102550797A (en) * | 2012-03-02 | 2012-07-11 | 大连海洋大学 | Production method of sea cucumber peptide extract |
| CN104738638A (en) * | 2015-01-09 | 2015-07-01 | 李晨悦 | Composition with anti-fatigue effect and application thereof |
| CN104886576A (en) * | 2015-06-11 | 2015-09-09 | 江苏慧博生物科技有限公司 | Female healthcare food and preparation method thereof |
| US20170312251A1 (en) * | 2016-04-30 | 2017-11-02 | Fairhaven Health, Llc | Nutritional supplements for improving female fertility |
| CN108741102A (en) * | 2018-06-12 | 2018-11-06 | 中肽生物科技（深圳）有限公司 | A kind of compound small-molecular peptides functional food of Bu Shen Zhuang waist salubrity and preparation method thereof |
| CN108902989A (en) * | 2018-06-21 | 2018-11-30 | 石丰 | A kind of auxiliary improves the ginseng peptide and preparation method thereof of cardiovascular and cerebrovascular disease |
| CN109674035A (en) * | 2019-01-21 | 2019-04-26 | 广州正广生物科技有限公司 | A kind of composition for relieving physical fatigue and preparation method thereof |
| CN111642748A (en) * | 2020-05-22 | 2020-09-11 | 广东长兴生物科技股份有限公司 | Anti-fatigue marine polypeptide composition and preparation method and application thereof |
| CN112779308A (en) * | 2019-11-04 | 2021-05-11 | 南京泽朗生物科技有限公司 | Preparation method of micromolecular oyster peptide |
-
2021
- 2021-06-16 CN CN202110667192.1A patent/CN115474692A/en active Pending
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102021215A (en) * | 2010-11-11 | 2011-04-20 | 湖北远成药业有限公司 | Method for extracting gelatin peptides |
| CN102550797A (en) * | 2012-03-02 | 2012-07-11 | 大连海洋大学 | Production method of sea cucumber peptide extract |
| CN104738638A (en) * | 2015-01-09 | 2015-07-01 | 李晨悦 | Composition with anti-fatigue effect and application thereof |
| CN104886576A (en) * | 2015-06-11 | 2015-09-09 | 江苏慧博生物科技有限公司 | Female healthcare food and preparation method thereof |
| US20170312251A1 (en) * | 2016-04-30 | 2017-11-02 | Fairhaven Health, Llc | Nutritional supplements for improving female fertility |
| CN108741102A (en) * | 2018-06-12 | 2018-11-06 | 中肽生物科技（深圳）有限公司 | A kind of compound small-molecular peptides functional food of Bu Shen Zhuang waist salubrity and preparation method thereof |
| CN108902989A (en) * | 2018-06-21 | 2018-11-30 | 石丰 | A kind of auxiliary improves the ginseng peptide and preparation method thereof of cardiovascular and cerebrovascular disease |
| CN109674035A (en) * | 2019-01-21 | 2019-04-26 | 广州正广生物科技有限公司 | A kind of composition for relieving physical fatigue and preparation method thereof |
| CN112779308A (en) * | 2019-11-04 | 2021-05-11 | 南京泽朗生物科技有限公司 | Preparation method of micromolecular oyster peptide |
| CN111642748A (en) * | 2020-05-22 | 2020-09-11 | 广东长兴生物科技股份有限公司 | Anti-fatigue marine polypeptide composition and preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101012471B (en) | Method for extracting rice bran protein by complex enzyme | |
| CN104357297B (en) | A kind of Tartary buckwheat health-preserving Chinese liquor and brewing method thereof | |
| KR101343038B1 (en) | Fermented corn protein hydrolysate and preparing method thereof | |
| KR100380318B1 (en) | Method for manufacturing the feed for hens using a red ginseng | |
| CN103320473B (en) | Method for produce monascus by using distillers' grain fermentation | |
| CN105918606A (en) | Extracting method of proteins in green tea dregs | |
| CN107751815A (en) | A kind of production method for digesting bone calcium powder | |
| CN111227246A (en) | Production method of coix seed extract | |
| Huang et al. | Changing the nutrient composition and enhancing the hydrolytic enzyme activity of citrus pulp residue by cofermentation with Candida utilis and Bacillus subtilis | |
| CN115474692A (en) | Nutritional composition for conditioning female endocrine function | |
| CN109486642A (en) | The method of bitter buckwheat oat bran Testa sojae atricolor brewing function mature vinegar rich in beta glucan | |
| CN101095486A (en) | Foodstuff production method by using gemmiparous unpolished rice powder and hemp seed as the raw materials | |
| CN105249005A (en) | Tea seed meal feed for promoting high yield of shrimps and preparation method of tea seed meal feed | |
| CN109897119A (en) | The method and purposes of pH value control and concentration in a kind of polysaccharides and polysaccharides preparation | |
| CN105557306A (en) | Method for producing medicinal myopias by utilizing radix ophiopogonis residue fermentation | |
| CN108752417A (en) | A kind of pollen pini active peptides | |
| CN101720816A (en) | Method for preparing acidophilus milk containing lucid ganoderma effective component | |
| CN107439921A (en) | A kind of processing method of glossy ganoderma fermentation rice meal | |
| CN109810830A (en) | A kind of bitter buckwheat highland barley wine starter and preparation method thereof | |
| CN104762166B (en) | A kind of fed-batch cultivation method preparing yellow wine with high alcohol content | |
| CN113679051A (en) | Peony polypeptide powder, solid beverage and application thereof | |
| CN111733038A (en) | Cistanche health-care wine and preparation method thereof | |
| CN111494443A (en) | Method for extracting anti-tumor metastasis active substance from Chinese actinidia root | |
| CN112262987A (en) | Fermented dietary fiber compound probiotic meal replacement powder | |
| CN104921239A (en) | Gastrodia elata and ox bone protein beverage capable of alleviating arthritis and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20221216 |