CN108783467A - Improve osteoporosis and increases the composition and preparation method thereof of bone density - Google Patents

Improve osteoporosis and increases the composition and preparation method thereof of bone density Download PDF

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Publication number
CN108783467A
CN108783467A CN201810567591.9A CN201810567591A CN108783467A CN 108783467 A CN108783467 A CN 108783467A CN 201810567591 A CN201810567591 A CN 201810567591A CN 108783467 A CN108783467 A CN 108783467A
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parts
composition
bone density
vitamin
increasing
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CN108783467B (en
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张大超
童星
胡元华
方颢
李方
贾建忠
陈琳
何海
王智颖
刘子圆
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Zhuhai Zhong Yue Yue Tai Health Technology Co Ltd
Sino Peptide (beijing) Healthy Technology Co Ltd
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Zhuhai Zhong Yue Yue Tai Health Technology Co Ltd
Sino Peptide (beijing) Healthy Technology Co Ltd
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
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    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
    • A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
    • A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
    • A23L33/25—Synthetic polymers, e.g. vinylic or acrylic polymers
    • A23L33/26—Polyol polyesters, e.g. sucrose polyesters; Synthetic sugar polymers, e.g. polydextrose
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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Abstract

A kind of composition for improving osteoporosis and increasing bone density, in terms of parts by weight, including following component：Oligomeric Gly-His-Lys 10-30 parts, 10-60 parts of glucide, 10-60 parts of dietary fiber, 5-30 parts of maltodextrin, 5-15 parts of calcium compound, 0.1-2 parts of multi-vitamins.Edible the composition can substantially reduce arthralgia and improve function of joint, the hydroxyl proline concentration of blood can be increased, reduce the bone-loss of densities in postmenopausal women with osteoporosis, and reinforce and extend the effect of osteosporosis resistant medicament treatment, there is the potential utility of prevention and treatment osteoarthritis and osteoporosis as nutrient.

Description

Improve osteoporosis and increases the composition and preparation method thereof of bone density
Technical field
The invention belongs to health product technology fields, specifically, being related to a kind of group of improvement osteoporosis and increase bone density Close object and preparation method thereof.
Background technology
With the aggravation of aging of population, the number for suffering from osteoporosis, osteoarthropathy and hypoimmunity is also increasing. Osteoporosis is reduced with bone amount, and the microstructure degeneration of bone is characterized, and the brittleness of bone is caused to increase and be prone to bone A kind of systemic skeletal disease of folding.Osteoporosis epidemiological survey shows that the generation of bone strength and fracture contains with bone mine It measures related, is the common disease of the middle-aged and the old, fracture can be caused, considerable distress and financial burden are brought to patient, be only Inferior to the second largest Health Killer of the mankind of angiocardiopathy.
Currently, the drug therapy of osteoporosis includes three parts, one of them is supplement calcium agent.According to our China The eating habit of people, the calcium that existing diet is capable of providing are not met by the needs for the treatment of osteoporosis, and therefore, patient is every It also needs to the calcium agent of 600~800 milligrams of supplement.Here it is the theoretical foundations of usually said " eating calcium tablet ".In addition to calcium agent, second Class drug is exactly vitamin D, especially activated vitamin D.Present medical field is that it is not only calcium phosphorus to the understanding of vitamin D The important adjusting factor of metabolism, and it is extremely important to the neuromuscular coordination of old man or even some doctors are vitamin D Status rise to the same height of same human hormone.Calcium agent and vitamin D all belong in the drug therapy of osteoporosis It is typically indispensable in Primary Care.Third class drug is exactly (bone amount to be made to increase the osteoblast for participating in bone metabolism Add), the function of osteoclast (bone amount is made to reduce) is adjusted.Specifically, exactly promote skeletonization or inhibit osteoclastic medicine Object.Clinically, with alendronic acid, zoledronic acid etc. be mainly the bisphosphonates of representative, also calcitonin, female swash Plain conditioning agent etc. inhibits the drug of the promotion skeletonization such as osteoclastic drug and parathyroid gland plain piece.These drugs are in osteoporosis It plays a major role in the treatment of disease, will generally be used for a long time, need patient strictly according to doctor's advice, rule medication is checked on schedule. So " eating calcium tablet " is a part for specification anti-osteoporosis treatment, effect is limited.External larger scale clinical is ground Study carefully and shows even if taking calcium agent and vitamin D on time, if no specification takes drug that is anti-osteoclastic or facilitating bone, for pre- It is still invalid for anti-fracture.So old man eats calcium tablet and do not have mistake, but it is leaned on to treat osteoporosis, then be much Inadequate.
In order to be better protected from or treat osteoporosis, someone is replenished the calcium using fish-bone powder product, such as Chinese patent CN201110098758.X is related to a kind of preparation for increasing bone density, prevention osteoarthropathy and strengthen immunity：Using sea The oligomeric Gly-His-Lys of foreign fish bone collagen, fishbone dust, eucommia ulmoides extracts, vitamin D, pharmaceutic adjuvant etc. are prepared, and fishbone dust belongs to big Molecular substance digests and assimilates effect unobvious.
Also some health products are added to diluent, disintegrant, lubricant, adhesive and coating agent etc., and preparation process is multiple Miscellaneous, auxiliary material additive amount occupies certain proportion, so that functional component content reduces, and health food is expensive, by employment Group is restricted.
Invention content
It is an object of the present invention to overcoming the prior art, a kind of improvement osteoporosis is provided and to increase bone close The composition of degree, edible the composition can substantially reduce arthralgia and improve function of joint, can increase the hydroxyl dried meat amine of blood Acid concentration reduces the bone-loss of densities in postmenopausal women with osteoporosis, and reinforces and extend the effect of osteosporosis resistant medicament treatment Fruit has the potential utility of prevention and treatment osteoarthritis and osteoporosis as nutrient.
The present invention improves osteoporosis and increases the composition of bone density, in terms of parts by weight, including following component：It is oligomeric 10-30 parts of Gly-His-Lys, 10-60 parts of dietary fiber, 5-30 parts of maltodextrin, 5-15 parts of calcium compound, are answered at 10-60 parts of glucide Close 0.1-2 parts of vitamin.
The oligomeric Gly-His-Lys are the oligomeric Gly-His-Lys of Marine fishbone collagen, belong to the peptides raw material of small component, and molecular weight is low, are easily inhaled It receives.When additive amount reaches 40 parts or more, the serious bitter taste of oligomeric Gly-His-Lys affects the mouthfeel of product so that sensory evaluation scores are drastically Decline, and at 30 parts or less, the sensory evaluation scores of product maintain 80 points or more in acceptable level；Dosage is too low, then changes Kind osteoporosis effect unobvious, consider the product nutritive value and mouthfeel is horizontal, by the oligomeric Gly-His-Lys of Marine fishbone collagen Additive amount be preferably 10-30 parts.
The glucide is Yi Daixin sugar, and Yi Daixin sugar has agent of low hygroscopicity, high stability, low in calories, high tolerance Property, the features such as sweet taste is pure.Yi Daixin sugar cannot be caused the microorganism of decayed tooth to utilize by oral cavity, will not form plaque, cause It decays tooth and causes periodontosis problem.Moreover, Yi Daixin sugar has the characteristic for inhibiting Fat Accumulation, fat oxidation being promoted to decompose, have Beneficial to the health of old man.
The dietary fiber is polydextrose, and polydextrose is a kind of water-soluble dietary fiber, is largely used to manufacture Reinforcing fiber food has the function of keeping stomach unobstructed after edible.Polydextrose, which removes, has insoluble diedairy fiber institute peculiar Obviously increase faecal volume, enhancing defaecation, outside the effect for the risk etc. for reducing bowel cancer, also there is insoluble diedairy fiber institute Do not have or internal cholic acid is removed in unconspicuous function, such as combination, hence it is evident that reduces serum cholesterol, it is easier to be led to full abdomen Sense, can be substantially reduced postprandial blood glucose levels etc..
The calcium compound is one or more in ASPARTIC ACID calcium, calcium carbonate, newborn mineral salt, calcium lactate.
The multi-vitamins are vitamin A. D. E, C, B1、B2、B6、B12, niacin, folic acid, pantothenic acid mixture, mix It is 500-1500: 1-2: 10000-15000: 100000-200000: 1000-2000: 1000-2000: 1000- to close weight ratio 2000∶2-5∶12000-20000∶300-500∶4000-6000。
The present invention, which improves osteoporosis and the composition of increase bone density, can also be added 5-10 parts of inulin, stachyose 5-10 Part, inulin is deposit property polysaccharide in plant, is mainly derived from plant.Stachyose is naturally present in a kind of functionality in plant Oligosaccharide.
Inulin is added in beverage can increase product dietary fiber and oligosaccharide function, improve the suction of the minerals such as calcium, magnesium, iron 20% or more yield, increases the density of bone mineral.And bitterness can be covered, the feeling of people's softness is given, makes beverage flavor more It is dense, quality is more preferable.Animal experiment proves, feeds mouse 20d with stachyose, finds the mineral matter elements such as calcium, the iron in its body Content increase, the mineral matter element in thigh calcination ash content also accordingly increases.
The preparation method that the present invention improves the composition of osteoporosis and increase bone density includes the following steps：
Each component raw material is weighed according to formula, the powder prepared is packed into after being stirred in mixing machine by dry, sterilizing, filling, Packaging and storage.
The eating method that the present invention improves the composition of osteoporosis and increase bone density can 3 times a day, 5 grams every time, It can also eat at any time.
Beneficial effects of the present invention are as follows：The present invention improves osteoporosis and the composition of increase bone density and can significantly subtract Few arthralgia and improvement function of joint, can increase the hydroxyl proline concentration of blood, reduce densities in postmenopausal women with osteoporosis Bone-loss, and reinforce and extend the effect of osteosporosis resistant medicament treatment, there are prevention and treatment Bones and joints as nutrient Scorching and osteoporosis potential utility.
Specific implementation mode
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will Understand, the following example is merely to illustrate the present invention, and should not be taken as limiting the scope of the invention.
Embodiment 1
Table 1 is the formula of embodiment 1-6 and comparative example 1-2.The weight ratio of wherein multi-vitamins is：Vitamin A: dimension life Plain D: vitamin E: vitamin C: vitamin B1: vitamin B2: vitamin B6: vitamin B12: niacin: folic acid: pantothenic acid=660: 1.5∶12000∶100000∶1200∶1400∶1400∶2.4∶13000∶372∶5000。
1 embodiment 1-6 comparative examples 1-2 of table increases the food formula of bone density, g
2 embodiment 7-9 comparative examples 3-5 of table increases the food formula of bone density, g
Comparative example 3 on the basis of embodiment 9 with inulin instead of polydextrose, the formula of comparative example 4 with embodiment 9, Niacin is eliminated in its multi-vitamins, the formula of comparative example 5 is same
The dosage of embodiment 9, the oligomeric Gly-His-Lys of Marine fishbone collagen increases to 30 parts.
It includes following step that above example, comparative example, which improve osteoporosis and increase the preparation method of the composition of bone density, Suddenly：Each component raw material is weighed according to formula, the powder prepared is packed into after being stirred in mixing machine by dry, sterilizing, filling, packaging Storage.
Experiment one：
Female adult SD rats are taken, 300 grams or so, are adapted to one week before testing.Semi-finished product are prepared with reference to AIN93 feed formulas Feed, in substitution of materials feed appropriate derive from soybean ingredient, to avoid phytoestrogens such as isoflavones to reality Test the interference of result.Daily gavage is primary, feeds 90 days altogether.Rat drinks deionized water during entire experiment.Test intended is divided into 15 groups cut off ovary, establish mouse castration osteoporosis model.Then osteoporosis rat is grouped, every group 10 Animal, unified feed, one group of control group take in the maltodextrin of equivalent；Other 14 groups are pressed embodiment 1-9, and comparative example 1-5 is additional Product is taken in, eating method is 1 gram every time 3 times a day.It is tested as follows：Left femur is taken after the test, is disappeared after weighing Change, aas determination calcium content of bone；Right side femur is taken, the bone at femur midpoint and distal end is measured with toy borne densitometers Density.It the results are shown in Table 3.
Table 3
It is found through experiments that, the effect of embodiment 9 is best, therefore illustrates asparagus amino-acid calcium, Marine fishbone collagen oligopeptide With inulin composite edible, has to castration rat model and dramatically increase bone density effect.
Experiment two：
The close osteoporosis female patient progress randomized control study of 150 60-65 Sui weight of selection, every group of 10 people, Unified diet.One group of control group, takes in the maltodextrin of equivalent；Other 14 groups are pressed embodiment 1-9, and comparative example 1-5 additionally takes in Product of the present invention, eating method are 3 times a day, 5 grams every time, to take 3 months.Embodiment 1-6 be respectively asparagus amino-acid calcium and The Contrast on effect of calcium carbonate, embodiment 7-9 are about the formula that inulin and/or stachyose is added.By measuring patient's hip bone Density to tester carry out efficacy assessments, borne densitometers using Holgic companies of the U.S. production dual-energy x-ray borne densitometers into Row test, on the center line on scan table, thigh is kept flat on platform patient lies supine, and foot is fixed on special tripod, and lower limb are in interior Revolve 25 ° of positions.Laser positioning is originated below pubic symphysis, scanning range：Femoral head, greater trochanter, femoral shaft proximal end, under rotor 2.5cm.According to WHO bone density diagnostic criteria when judgement, the T >=-1 of femoral neck bone density is normal, and -1 > T > -2.5 are low bone Amount, T≤- 2.5 are osteoporosis.It the results are shown in Table 4, table 5, data are number in table.
Table 4
Table 5
As a result, it has been found that arthralgia can be substantially reduced for 3 months and improve function of joint by taking, collagen peptide can increase The hydroxyl proline concentration healed reduces the bone-loss of densities in postmenopausal women with osteoporosis, and reinforces and extend anti-osteoporosis The effect of drug therapy.Collagen peptide and asparagus amino-acid calcium composite edible as nutrient there is prevention and treatment bone to close The scorching potential utility with osteoporosis of section.From table 4, table 5 as can be seen that the therapeutic effect added with inulin is best.
The above content describes the basic principles and main features of the present invention, and the present invention is not limited to the above embodiments, Without departing from the spirit and scope of the present invention, various changes and improvements may be made to the invention, these changes and improvements are all It falls into scope of the claimed invention.

Claims (10)

1. a kind of composition for improving osteoporosis and increasing bone density, it is characterised in that in terms of parts by weight, including such as the following group Point：Oligomeric Gly-His-Lys 10-30 parts, 10-60 parts of glucide, 10-60 parts of dietary fiber, 5-30 parts of maltodextrin, calcium compound 5- 15 parts, 0.1-2 parts of multi-vitamins.
2. improving osteoporosis according to claim 1 and increasing the composition of bone density, it is characterised in that described is oligomeric Gly-His-Lys are the oligomeric Gly-His-Lys of Marine fishbone collagen.
3. improving osteoporosis according to claim 1 and increasing the composition of bone density, it is characterised in that the carbohydrate Substance is Yi Daixin sugar.
4. improving osteoporosis according to claim 1 and increasing the composition of bone density, it is characterised in that the diet Fiber is polydextrose.
5. improving osteoporosis according to claim 1 and increasing the composition of bone density, it is characterised in that the calcification Conjunction object is one or more in ASPARTIC ACID calcium, calcium carbonate, newborn mineral salt, calcium lactate.
6. improving osteoporosis according to claim 1 and increasing the composition of bone density, it is characterised in that described is compound Vitamin is vitamin A, vitamin D, vitamin E, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, cigarette The mixture of two kinds in acid, folic acid and pantothenic acid or two or more substances.
7. improving osteoporosis according to claim 6 and increasing the composition of bone density, it is characterised in that the vitamin A、D、E、C、B1、B2、B6、B12, niacin, folic acid, pantothenic acid mixture weight ratio be 500-1500: 1-2: 10000-15000: 100000-200000∶1000-2000∶1000-2000∶1000-2000∶2-5∶12000-20000∶300-500∶4000- 6000。
8. improving osteoporosis according to claim 1 and increasing the composition of bone density, it is characterised in that be additionally added inulin 5-10 parts.
9. improving osteoporosis according to claim 1 and increasing the composition of bone density, it is characterised in that be additionally added wood It is 5-10 parts sugared.
10. special according to the preparation method of any compositions for improving osteoporosis and increasing bone density of claim 1-9 Sign is to include the following steps：Each component raw material is weighed by formula, dry, sterilizing is packed into mixing machine after stirring 30-40min, Canned, packaging and storage.
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Cited By (4)

* Cited by examiner, † Cited by third party
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CN109601861A (en) * 2018-12-04 2019-04-12 沈阳师范大学 A kind of full grain nutrition powder of pre- preventing bone rarefaction and preparation method thereof
CN110892991A (en) * 2019-12-27 2020-03-20 北京康比特体育科技股份有限公司 Composition for increasing bone density and preparation method and application thereof
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CN110892991A (en) * 2019-12-27 2020-03-20 北京康比特体育科技股份有限公司 Composition for increasing bone density and preparation method and application thereof
CN115190765A (en) * 2020-02-27 2022-10-14 雅培制药有限公司 Method for improving bone health
CN116082454A (en) * 2022-09-09 2023-05-09 大连工业大学 Polypeptide with bone mineral density regulating activity and application thereof

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