CN102318835A - Composition for reducing bone loss and preparation method thereof - Google Patents
Composition for reducing bone loss and preparation method thereof Download PDFInfo
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- CN102318835A CN102318835A CN 201110255107 CN201110255107A CN102318835A CN 102318835 A CN102318835 A CN 102318835A CN 201110255107 CN201110255107 CN 201110255107 CN 201110255107 A CN201110255107 A CN 201110255107A CN 102318835 A CN102318835 A CN 102318835A
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Abstract
The invention discloses a composition for reducing bone loss and a preparation method thereof. The composition is prepared from a calcium compound, marine fishbone collagen oligopeptide powder, glucosamine hydrochloride, casein phosphopeptides, natural vitamin E, vitamin C, vitamin K1, vitamin B12, vitamin D3 and dietary fiber. As proved by animal and human body tests, the composition has the effects of increasing bone density, enhancing bone intensity, reducing bone loss, delaying aging and enhancing the immunity, and can be taken by the middle-aged and old as a health-care food for a long time. The preparation method is scientific and reasonable, and is suitable for industrial production.
Description
Technical field
The present invention relates to a kind of composition and method of making the same that reduces bone-loss, be specifically a kind of can enhance bone density, increase bone toughness and elasticity, the old and feeble health food of prevention bone, belong to food technology field.
Background technology
Aging is body tissue structural change and the hypokinetic a kind of organic growth process that occurs along with the increase at age.Be accompanied by human senility, the metabolism of body bone also can get muddled, and the balance between Gegenbaur's cell and osteoclast effect is broken; Bone absorbs greater than bone and forms, and causes that the bone amount reduces, and bone density descends; Finally cause osteoporosis; Pain in back and loin, spine malformation can be arranged, and very easily fracture, have a strong impact on people's quality of life.In addition, the osteoporosis that deteriorates to characteristic with low bone amount and bone tissue fine structure becomes middle-aged and old common disease and frequently-occurring disease, and it is to cause the systemic disease that bone fragility increases and bone density reduces and fracture risk increases.According to statistics, the women's osteoporosis incidence of disease more than 60 years old is 60-70%, and performance has osteoporotic middle-aging male that certain proportion is also arranged.The clinical manifestation of osteoporosis mainly is that whole body ostalgia is unable, is main with the small of the back and fracture site rest pain, and activity obviously is restricted.Along with the continuous growth of population and the arrival of astogeny society; Its incidence is ascendant trend gradually; Gradually, become a serious social concern; Therefore many people suffer sensual misery for a long time, even wounded or disabled and early death, and high medical fee brings heavy financial burden and huge stress also for family and society.Prevention and treatment of osteoporosis has become one of global important public hygiene problem at present, has become the serious hot issue of paying close attention to of society.About 200,000,000 people in the whole world suffer from osteoporosis, and its incidence of disease has leapt to common disease, frequently-occurring disease the 7th.The osteoporotic Chinese and Western medicine of treatment is more at present, but the complex treatment effect is very unobvious mostly, and rehabilitative action is also significantly little, has the imperfection part, is not up to the present medically finding safe and effective radical cure method as yet.
Bone density, full name " bone mineral density " is the leading indicator of bone strength, is an important symbol of bone mass, reflection osteoporosis degree, the important evidence of prediction fracture risk.People's bone density is will be with the growth at age year by year because of bone loss descends behind the peaking about 30 years old, and the women is faster than elderly men in the speed that climacteric begins the back bone loss.It is reported, men and women no matter, after 60 years old, 20%～30% during the general peaking of bone loss amount, maximum reaches 40%.With advancing age; Compare with the young man below 30 years old under the identical nutritional condition, these the elderly still occur sclerotin inevitably and lose in a large number, and bone density descends; Bone strength reduces; Become loose easy to break gradually, thereby the elderly is normal because of bone density decline causes osteoporosis not have the fracture of inducement, especially good position is femur and lumbar vertebrae.
Therefore, pay attention to today of life quality and living space, how the enhancing body ability that delays senility in People more and more; Increase bone density and intensity; Help loose bone to restore to the original state, it is particularly important that the delaying human body caducity process seems, and have active operation significance.Therefore exploitation increases bone density and anti-aging health food ten minutes necessity.
A Chinese patent, CN101695382 A number disclose a kind of calcium-supplementing preparation that improves bone and function of joint that has concurrently; Be main the composition such as calcium source, ammonia carbohydrate, CPP, bone collagen, anti-oxidant composition etc.; Its preparation technology becomes fine powder with each raw material mixed grinding, excessively compressing tablet behind the 60-150 mesh sieve.But there is not vitamin D in this patented foodstuff composition; Simultaneously, though it contains bone collagen, do not consider that can bone collagen be absorbed by the body; In addition, among its preparation technology raw material is directly mixed abrasive dust, its flowability and poor compressibility; Can't realize suitability for industrialized production, product weight difference is big, influences product quality.
Summary of the invention
The present invention seeks to overcome above-mentioned prior art defective, a kind of composition that reduces bone-loss is provided, it can take all factors into consideration the influence factor that stops old and feeble each link of health food of bone, component is reasonable, health-care effect is obvious, is suitable for suitability for industrialized production.
Simultaneously, the present invention also will provide the preparation method of this health food.
Purpose according to the invention realizes through following technical scheme.
A kind of composition that reduces bone-loss, it is processed by the component of following weight portion:
Calcium compound 30-80 part, Marine fishbone collagen oligopeptide powder 1-50 part, aminoglucose hydrochloride 5-30 part, CPP 1-20 part, natural VE powder 0.25-7.5 part, vitamin C 1.5-50 part, vitamin K
1Powder 0.02-0.1 part, Cobastab
120.00005-0.0005 part, vitamin D
3Powder 0.000075-0.0005 part, dietary fiber 1-20 part.
The composition of above-mentioned minimizing bone-loss, its preferred component content is: calcium compound 40-60 part, Marine fishbone collagen oligopeptide powder 5-20 part, aminoglucose hydrochloride 8-20 part, CPP 4-10 part, natural VE powder 4-10 part, vitamin C 4-10 part, vitamin K
1Powder 0.02-0.05 part, Cobastab
120.00008-0.0001 part, vitamin D
3Powder 0.00009-0.0002 part, dietary fiber 2-8 part.
Calcium compound is at least a in calcium carbonate, calcium citrate, calcium gluconae, calcium lactate, calcium malate, Calcium Ascorbate, calcium monohydrogen phosphate, calcium dihydrogen phosphate, calcium acetate, calcium caseinate, calcium chloride, calcium citrate malate, calcium phosphate, calcium sulfate, calcium glycerophosphate or the amino acid chelated calcium in the said component.
Ossein is meant that molecular weight is less than 1000 daltonian Marine fishbone collagen oligopeptide powder.
The composition of above-mentioned minimizing bone-loss, it also comprises the auxiliary material of following weight portion:
Diluent 0-40 part, disintegrant 0-10 part, lubricant 0.5-5 part, adhesive 0-5 part, coating agent 0-3 part.
The preferred content of said auxiliary material is: diluent 4-10 part, disintegrant 1-5 part, lubricant 0.8-2 part, adhesive 0.5-3 part, coating agent 2-3 part.
The component of food compositions of the present invention and dosage ratio are according to the anti-ageing theory in the modern medicine and medicines and health protection health theory and modern pharmacology Design Theory; Purpose is the cause of disease that takes place to modern middle-aged and old osteoporosis; On the root to people provide a kind of function definite, have no side effect, can take for a long time, can stop the health food that bone is old and feeble, reinvent young bone from root.
The present invention prescription is that sorbefacient, multivitamin, aminoglucose hydrochloride, ossein (Marine fishbone collagen oligopeptide powder), the dietary fiber with calcium complement agent, calcium be basis, has overcome that a lot of products are directed against middle-aged and old weakness that osteoporosis is replenished the calcium merely of improving on the market.Sorbefacient (CPP, the VD of calcium complement agent (calcium source) and calcium
3) and VK
1, VB
12Combination, the bone density that can effectively improve the elderly descends, and improves bone strength; Marine fishbone collagen oligopeptide has replenished the required ossein of bone, has strengthened bone toughness and can prevent calcium loss, and the material choice of ossein uses molecular weight less than 1000 daltonian Marine fishbone collagen oligopeptide powder, is prone to absorb, and biological utilisation improves; Aminoglucose hydrochloride has increased joint flexibility ratio and bone toughness; Natural VE, VC can effectively remove free radical, and the specific (special) requirements that satisfied the elderly delays senility has stoped bone old and feeble; Simultaneously, consider use crowd's characteristic, along with the age increases, middle-aged and old gastrointestinal functions also decrease, and activity reduces in addition, constipation easily.Simultaneously take calcium for a long time and also cause constipation easily, middle-aged and old intestines and stomach defaecation problems has been regulated in the suitable adding of dietary fiber.In sum, the present invention has stoped middle-aged and old bone old and feeble from root, can reinvent out young more bone, and safely, have no side effect, can eat for a long time.
Contain vitamin D in the composition of the present invention
3, Cobastab
12, vitamin K
1, through with do not contain vitamin D
3, Cobastab
12, vitamin K
1The blank group relatively, after the volunteer that replenishes the calcium takes 1 month,, measure two groups lumbar vertebrae and femur density through dual intensity X line absorption determination method, discovery contains vitamin D
3, Cobastab
12, vitamin K
1Present composition group can obviously improve the bone tissue mechanical strength (P＜0.01) of bone BMD and lumbar vertebrae and femur; Reflected that said composition maybe be through acting on different histoorgans, many target spots, too many levels, multipath are regulated the bone absorption and bone forms, and improve bone metabolism situation; Can increase the bone amount; Keep the normal configuration of bone, the mechanical property of bone is improved, the adding of three kinds of vitamins has produced collaborative facilitation makes the calcareous absorptivity of composition improve 5%.
The preparation method of health food according to the invention is:
A. take by weighing each component and auxiliary material by prescription, with said vitamin C, aminoglucose hydrochloride, vitamin K
1Powder, vitamin D
3Powder, Cobastab
12Sieve respectively, subsequent use;
B. adhesive is made into the aqueous solution of mass concentration 8%, and is subsequent use;
C. calcium compound, aminoglucose hydrochloride add the aqueous solution and process softwood respectively, granulate, and drying, whole grain makes calcium compound particle and aminoglucose hydrochloride particle;
D. with vitamin K
1Powder, Cobastab
12, vitamin D
3Powder and CPP shake on Highefficientpowersifter by the equivalent method of progressively increasing and sieve twice, and sieve number is 80 orders, and mixing makes mixture one;
E. said mixture one is shaken on Highefficientpowersifter with vitamin C, natural VE powder and sieve twice, mixing, sieve number is 40 orders, makes mixture two;
F. prepared calcium compound particle, aminoglucose hydrochloride particle, Marine fishbone collagen oligopeptide powder, dietary fiber, diluent, disintegrant, lubricant and said mixture dual-purpose mixer among the step c were always mixed 30 minutes; Make the total mixture particle; With particle directly packing process granule, or encapsulatedly process capsule or its compressing tablet in tablet press machine made label;
G. said coating agent is dissolved in the ethanol; Stir and add purified water after 10 minutes; Stir and made coating solution in 45 minutes; The concentration of coating agent is 10% (W/W) in the said coating solution, and concentration of ethanol is 70%, and label described in the step f is put into the tablet that dressing machine dressing promptly makes health food.
Above-mentioned preparation method is with whole granule that promptly gets health food of the total mixture particle that makes among the step f.
Above-mentioned preparation method promptly gets the total mixture granule filling capsule that makes among the step f capsule of health food.
Vitamin powder after the present invention handles with microcapsule technology is done raw material, has both increased product stability, and trace element can be mixed, and has guaranteed the product content uniformity.Its jolt ramming front volume, tap volume are measured; Estimate through projects such as Ka Er coefficient, compressibility coefficient, Hausner Ratio and angles of repose; Prove that composition molding of the present invention has had tangible change, unilateral smooth, sheet is heavily stable can be easy to control; Hardness and friability have reached storage and requirements on transport, have improved product quality.Contrast test and technical Analysis are following:
Evaluation criterion: it has been generally acknowledged that angle of repose＜40
0, mobile relatively good.
Measure jolt ramming front volume (V according to the method for USP24＜616＞provide
0) and tap volume (V
f), take by weighing sample 50 grams;
Ka Er coefficient=(V
0-V
f)/V
f
Compressibility coefficient=100 (V
0-V
f)/V
0
Hausner?Ratio=V
0/V
f；
The evaluation coefficient (related) of compressibility coefficient and Hausner Ratio:
The present composition and the patent No. are that mobile property of the invention composition of CN101695382 A and compressibility are measured the result:
Technical Analysis: material fluidity and the compressibility of pulverizing the preparation method preparation that directly mixes the back with material are all very poor, the formulation preparation difficulty.By the sample of this prepared through visual examination, tablet weight variation (according to the correlation technique of two ones of Chinese Pharmacopoeia versions in 2010), hardness (according to detection method) and friability (according to the correlation technique of two ones of Chinese Pharmacopoeia versions in 2010) to tablet; Testing result is that outward appearance is coarse, tablet weight variation is big, hardness is little; Sheet heavily is difficult to control, can not satisfy industrialized production.And by the sample of present composition prepared, bright in appearance, tablet weight variation is little, hardness is suitable, friability meets standard-required.The constant product quality of producing, each item index test all meets the requirements, and is well suited for industrialized production.
All confirm the function that product of the present invention has to be increased bone density, delay the bone aging through animal experiment and human trial,, do not find toxic effect of this product and mutagenesis etc. through toxicological test.Further specifying it below in conjunction with animal and function test increases bone density, delays function such as bone aging.
Experiment 1: safety non-toxic test
The present invention confirms safety non-toxic through animal experiment, and result of the test and conclusion are following:
(1), acute toxicity test: the acute oral MTD of rat all greater than 15g/kg.bw, is declared the genus non-toxic type.
(2), three genetic toxicity tests such as the test of Salmonella reversion test, bone marrow cell micronucleus and sperm malformation test are negative findings, show no mutagenesis.
(3), do not see in the feeding trial in 30 days and the ANOMALOUS VARIATIONS of animal health condition, biochemistry, hematological indices and organ-tissue form prove safety non-toxic of the present invention.
Experiment 2: increase the bone density function test
The present invention confirms to have the bone density of increasing function through animal experiment, and result of the test and conclusion are following:
The influence heavy to rat body weight, bone (x ± s)
★, compare P＜0.05 with low calcium control group;
Result of the test shows: the low calcium control group of the right femur bone weight average of three dose groups and high dose calcium carbonate group obviously increases (P＜0.05), has the effect that increases calcium content of bone.
To the influence of rat bone density and calcium content of bone (x ± s)
Result of the test shows: the bone density of basic, normal, high three dose groups is significantly higher than low calcium control group (P＜0.01); The right femur calcium content of three dose groups and high dose calcium carbonate group all obviously increases (P＜0.05) than low calcium control group, has the effect that increases bone density.
Experiment 3: collagen oligopeptide powder and vitamin K
1Synergy
Molecular weight is less than 1000 daltonian bone collagen oligopeptide powder, with vitamin K
1The associating use through the function assessment experiment to bone, in contrast experiment's data demonstration of small white mouse, aspect increase bone density and bone toughness, replenishes collagen oligopeptide powder, with vitamin K simultaneously
1The associating use is better than traditional effect of supplemented calcium, result of the test with judge as follows:
Influence to rat femur biomethanics index
。
The animal test results of health food of the present invention shows: compare with model control group, 5 times, 10 times, 20 times three dose groups femur calcium content raises, and 10 times, 20 times two dose groups femur dry weight, femur mid point and distal end density also obviously raise.According to " health food function assessment assessment process and method of inspection standard " (2003 editions), judge the effect that composition of the present invention has increases bone density and bone toughness.
Above-mentioned check is popular; Exactly through to experimental mouse feeding bone collagen oligopeptide powder and vitamin K composition with carry out control experiment that tradition replenishes the calcium and verify that bone collagen oligopeptide powder and vitamin K composition are in the effect aspect increase bone density and the bone toughness; Scientific experiment proves; Composition of the present invention has the function that increases bone density and bone toughness; Can obviously improve the anti-fracture ability of human body, also just prove that collagen hyalronic albumen oligopeptide powder and vitamin K composition are better than traditional effect of supplemented calcium simultaneously.
Experiment 4: deferring senility test
The present invention confirms to have deferring senility through animal experiment, and each item evaluation criterion shows that deferring senility animal test results of the present invention is positive.
The present invention further confirms to have deferring senility through human trial, and concrete result of the test and conclusion are following:
Hematology detection index before and after the test (X ± SD)
Blood MDA content, SOD activity and GSH-Px activity change situation before and after the test (X ± SD)
Annotate: compare P＜0.05 before and after the * self, compare P＜0.05 between the # group
Test front and back blood lipid peroxide (MDA) content situation: compare MDA content before and after the test of test-meal group and all be lower than test preceding (P＜0.05); And significantly be lower than control group (P＜0.05).
Blood superoxide dismutase (SOD) activity change situation before and after the test: self compare the active no significant difference (P＞0.05) of SOD before and after the control group test; Test-meal group test back is relatively preceding with test, active significantly raise (P＜0.05) of SOD.
Blood glutathione peroxidase (GSH-Px) activity change situation before and after the test: self compare the active no significant difference (P＞0.05) of GSH-Px before and after the control group test; Test-meal group test back is relatively preceding with test, active significantly raise (P＜0.05) of GSH-Px.
Delaying senility function shows through the human feeding trial result: no abnormality seens such as duration of test experimenter's spirit, diet, sleep, stool and urine, health check-up each item safety indexes is no abnormality seen also, shows that the present invention has no adverse effects to human body.Test back test-meal group MDA content significantly is lower than before the test and significantly is lower than control group; Before blood superoxide dismutase (SOD) activity is significantly higher than test; Before blood glutathione peroxidase (GSH-Px) activity also is significantly higher than test.By evaluation criterion: the present invention has deferring senility.
The suitable the elderly of health food of the present invention, eating method is each 1, every day 2 times.
The present invention has no side effect through the evidence of animal and human's body, and has the function that increases bone density, enhance bone intensity, minimizing bone-loss and delay senility, and can be the elderly and takes for a long time as health food.
Calcium among the present invention is the tissue that mineralizes in the health---the essential minerals of bone and tooth is the basic nutrition of maintaining bone density, also is an important dietary factors that influences bone density.When calcium absorption or calcium incomplete absorption, will bring out hyperparathyroidism, cause then mobilizing from the bone of bone, discharge more calcium to keep the calcium stable of serum, therefore bone loss takes place.Therefore, the status of calcium in prevention and treatment osteoporosis is very important and irreplaceable.Calcium carbonate is as calcium tonic, is the highest a kind of of calcium content, dissolves in hydrochloric acid in gastric juice, is to use maximum calcium tonics.
Ossein is one of main component of bone tissue, for calcified tissue provides requisite three-dimensional structure and mineral deposit is had inducing action.It can promote the depositions of inanimate matter on bone such as calcium, phosphorus, thereby can play and repair bone tissue, improve the osteoporosis symptom, promote healthy effect.The calcium that human body absorbed is just effectively to be utilized by bone through the link effect of ossein.Ossein also is to form the important component of human muscle, skin, has very great help for the toughness, the harmony of human motion and the elasticity of skin that keep bone.Synthetic self ossein of body need provide sufficient strong proline.The amino acid ratio of components of ossein is more special, and it is rich in strong proline.With age, the quantity and the ability of the synthetic collagen of human body self can slowly can't satisfy daily need, and simple effect of supplemented calcium is not good enough, if because ossein is replenished deficiency, the matrix of bone can not form, and calcium salt then can't deposit; Opposite simple additional collagen, more sufficient even bone matrix forms, but calcium deposition is few, still can not make the bone normal growth.The metabolism of ossein can also promote the metabolism of cell, strengthens the nutrition of cartilage synovial membrane, strengthens bone density, increases the toughness and the anti-fracture ability of bone, thereby plays anti-ageing, as to promote growth effect.
The U.S., Europe and Japanese a large amount of medical researches show: Glucosamine can help to repair and safeguard cartilage and the growth that can stimulate the cartilage cell.An amount of Glucosamine that replenishes of the elderly, the arthritic generation of prevention of bone property, or improve symptom, also useful to shoulder pain and gonalgia due to scapulohumeral periarthritis, fascitis, the cervical spondylopathy.When the treatment osteoporosis, replenish Glucosamine, can also increase eburnation degree, flintiness.In addition, Glucosamine also have delay senility, delay senility, the liver defencive function.Test shows: Glucosamine can the enhancing body specific cellular immunity and the function of humoral immunity.If together use with antibiotic, can promote the absorption of antibiotic in blood, reduce side reaction, also can suppress the growth of cancer cell.With advancing age, the shortage of the Glucosamine in the human body is more and more serious, and articular cartilage is constantly degenerated and worn and torn, and suitably replenishes Glucosamine and seems particularly important.
CPP (hereinafter to be referred as CPP) is a kind of good short calcium factor, is described as " mineral carrier ".Research at present shows that the effect that the short calcium of CPP absorbs mainly shows the following aspects: (1) promotes the absorption of small intestine to calcium.Cereal in people's the diet contains high phosphorus compositions such as a large amount of phytic acid, phytic acid, under small intestine lower end PH7～8 environment, combines with calcium and generates calcium phosphate precipitation.And CPP can suppress the formation of calcium phosphate precipitation, makes free calcium keep higher concentration, promotes the passive absorption of calcium, becomes the another approach of vitamin D as accelerating agent of calcium absorption.(2) promote the utilization of bone to calcium.Zoopery shows that CPP can promote the absorption and the utilization of calcium, weakens the absorption again of osteoclast effect and inhibition bone.(3) promote the utilization of tooth to calcium.Think in the past, chew after the meal cheese can saliva stimulating secretion, make acidic materials on the saliva buffering dental plaque of alkalescence to adamantine corrosion, help to prevent the generation of carious tooth.In recent years discover that the CPP that contains in the cheese can be combined in the calcium ion in the food carious tooth place, alleviate enamel go mineralize, thereby reach anti-dental caries purpose.
Cobastab
12Osteoblastic function there is direct effect, discovers Cobastab
12With BGP, alkaline phosphatase correlation is arranged.The You Li of affiliated hospital of Shanghai Communications University etc. are to postmenopausal women's blood Cobastab
12, folic acid water article and bone density correlation carried out Primary Study, finds the elderly woman Cobastab
12Bone loss speed is faster than homovitamin B
12Group, concurrent existing osteoporosis is compared Cobastab with the women that the bone amount reduces with the women of normal bone amount
12Level is lower, and each organizes women's folate level no significant difference.This research shows Cobastab
12With bone density correlation is arranged.
Vitamin C has important function as a kind of important reducing agent in bone salts metabolism and sclerotin generation.It can promote the generation of bone matrix, increases osteogenesis function; It can increase the deposition of calcium salt, stimulates the formation of cultured cell mineralising tubercle, for the differentiation institute of osteoclast necessary; Simultaneously being again the synthetic raw material of collagen, participating in the proline hydroxylation with synthetic collagen, is to form the necessary material of collagen.The research proof, the generation of collagen is influential to bone strength, and I Collagen Type VI defective is little to the BMD influence, but can cause the obvious reduction of bone strength, and the trend of collagenous fibres also can influence bone strength.In the research that the Gegenbaur's cell that exsomatizes is cultivated, the interior alkaline phosphatase activities of cell, cell proliferation and the I Collagen Type VI gene mRNA expression that add the VC group all have increase.Ascorbic physiological function mainly shows as: promote the biosynthesis of ossein, be beneficial to the healing sooner of tissue injury mouth; The metabolism of tyrosine and tryptophan prolongs the human body life-span in the promotion amino acid; Improve the utilization of iron, calcium and folic acid; Improve fat and the particularly metabolism of cholesterol of lipoid, Prevention of Cardiovascular is sick; Promote tooth and skeletal growth, prevent that gum is hemorrhage, prevent arthralgia, pain in waist and lower extremities; Strengthen the human body anti-stress ability and the immunity of environment to external world.
The level of body vitamin D and bone density, the strong density of muscle is relevant, and vitamin D is the main adjusting factor that calcium absorbs, and can help absorption of human body calcium, improves the human body bone density effectively and takes in the peak value that calcium can be kept to the long duration bone density.It can fully assist calcium effectively to play a role, and promotes new bone calcification and bone to form, and reduces bone loss, significantly increases the elderly's bone density.Shortage or not enough human body also can cause the Secondary cases parathyroid function to increase to the incomplete absorption 10% of calcium, increase the bone conversion, promote bone loss, cause osteoporosis and fracture.Human body self can synthesize a spot of vitamin D, and this synthetic conversion capability of the elderly declines to a great extent, and the underfed danger of vitamin D takes place to be increased greatly, influences the absorption and the utilization of calcium, and vitamin D Can is just necessary.
Vitamin K increases the synthetic of Gegenbaur's cell BGP as the dependence vitamin of multiple protein in the bone, but that is to say the mineralization of enhance bone, to prevention of osteoporosis and treatment certain effect will be arranged, and its wide material sources, low price.Vitamin K is the key factor that prevention adult bone strength descends, and is even more important to postclimacteric middle aged and aged women.A large amount of survey datas find that if the vitamin K intake in women's meals is lower, the danger that osteoporosis and femoral fracture take place for they is just bigger.Yet the strong bone effect of vitamin K and calcium is also inconsistent, and it can't obviously improve the density of bone, but can help calcium to get into bone matrix better, obviously improves the flexural capacity of bone.
Natural VE is the most representative fat-soluble natural agent that delays senility that is positioned film, has powerful anti-radical action, can protect cell membrane and intracellular nucleic acid to avoid free radical and attack, and be one of the material that the most effectively delays senility in the human body.Vitamin E can strengthen the delaying senility function of cell.Because vitamin E itself very easily is oxidized to fertility phenolic group and fertility quinonyl, can protect ambient substance not oxidized, in cell, eliminates the free radical that body is had detrimental effect, prevents the formation of lipofuscin.Simultaneously vitamin E can also the diaphragm phospholipid composition in unsaturation aliphatic acid, the stabilate membrane structure, the vigor of diaphragm desmoenzyme and acceptor etc. are kept biomembranous normal function.
Vitamin C is the same with vitamin E also to be the agent that delays senility, and vitamin C is a kind of water-soluble agent that delays senility, and delaying senility is ascorbic exemplary functions.In addition, vitamin C also has protective effect to vitamin E, and its reduction characteristic can make the stability of vitamin E strengthen, and the effect performance is more abundant, when two kinds of vitamins are used in combination, can strengthen their effect that delays senility, and plays synergy.
Along with Food Science man to the deepening continuously and the progressively raising of consumer of its research to dietary fiber understanding, dietary fiber will equally become the indispensable nutritional labeling of human diet with other " six big nutrients ", be called as " the 7th nutrient ".The physicochemical property of dietary fiber mainly contains: stronger suction and expansion function; Can change microbiologic population's composition in the intestinal tract; Function with adsorb organic compound; Combine and function of exchange with cation.These physicochemical characteristics of dietary fiber make it have unique physiological function and nutrition health-care functions.Mainly show the following aspects: the defaecation antiobesity action; Improve intestinal microenvironment; Regulate the blood sugar effect; Absorbing fats, cholesterol and cholate; Remove the harmful substance effect; The effect of bringing high blood pressure down; Strengthen the health immunologic function.
The specific embodiment
Below in conjunction with embodiment the present invention is further specified:
Embodiment 1
Take by weighing the component of following weight portion: 40 parts in calcium carbonate, 19.3 parts in Marine fishbone collagen oligopeptide powder, 8 parts of aminoglucose hydrochlorides, 4 parts of CPPs, 4 parts in natural VE powder, 4 parts of vitamin Cs, vitamin K
10.02 part in powder, Cobastab
120.00008 part, vitamin D
30.00009 part in powder, 8 parts of dietary fibers, 8 parts of microcrystalline celluloses, 3 parts of sodium carboxymethyl starches, 0.8 part of dolomol, 30 0.8 parts of 30 POVIDONE K 30 BP/USPs, 3 parts of stomach dissolved film coating pre-mix doses.
The preparation method: (1) takes by weighing the component and the auxiliary material of above-mentioned weight portion, with said vitamin C, aminoglucose hydrochloride, vitamin K
1Powder, vitamin D
3Powder, Cobastab
12Pulverized 100 mesh sieves respectively, subsequent use;
(2) add purified water in the said adhesive, be made into 8% the aqueous solution, subsequent use.
(3) with said calcium compound, aminoglucose hydrochloride respectively in the trough type mixing machine; The aqueous solution with described in the step (2) is made softwood respectively; Crossing 20 mesh sieves with oscillating granulator granulates; In 60 ℃ of dryings, cross 20 mesh sieves with oscillating granulator again and carry out whole grain, make calcium compound particle and aminoglucose hydrochloride particle;
(4) with vitamin K
1Powder, Cobastab
12, vitamin D
3Powder and CPP shake on Highefficientpowersifter by the equivalent method of progressively increasing and sieve twice, and sieve number is 80 orders, and mixing makes mixture one;
(5) with said mixture one and vitamin C, the natural VE powder sieve twice that on Highefficientpowersifter, shakes, mixing, sieve number is 40 orders, makes mixture two;
(6) prepared calcium compound particle, aminoglucose hydrochloride particle, Marine fishbone collagen oligopeptide powder, dietary fiber, diluent, disintegrant, lubricant and said mixture dual-purpose V-Mixer in the step (3) were always mixed 30 minutes; Make the total mixture particle, its compressing tablet in tablet press machine is made label;
(7) said coating agent is dissolved in the ethanol, stirs and add purified water after 10 minutes, the powerful stirring made coating solution in 45 minutes, and the concentration of coating agent is 10% (W/W) in the said coating solution; Concentration of ethanol is 70%, and label described in the step (6) is put into the dressing machine, starts the preheating that slowly runs of dressing machine, makes the sheet surface temperature reach 35-40 ℃; Open spray gun spray film, initial flow can be big slightly, observes the label situation at any time in the spray membrane process; The speed of adjustment spray in time, dressing machine rotating speed notice that the sheet surface temperature can not be too high, wet excessively, label weightening finish 3%; The heavy 1.0g of sheet has sprayed continued and has blown about 30 minutes with cool breeze, takes out to put into to dry in the air and dries about 2 hours between sheet.Dressing promptly makes said health food.
Embodiment 2
Prescription: 50 parts of calcium citrates, 10 parts in Marine fishbone collagen oligopeptide powder, 10 parts of aminoglucose hydrochlorides, 5.5 parts of CPPs, 5 parts in natural VE powder, 50 parts of vitamin Cs, vitamin K
10.03 part in powder, Cobastab
120.00009 part, vitamin D
30.0001 part in powder, 5 parts of dietary fibers, 4.6 parts of pregelatinized starch, 3 parts of sodium carboxymethyl starches, 0.8 part of dolomol, 30 1.0 parts of 30 POVIDONE K 30 BP/USPs, 3 parts of stomach dissolved film coating pre-mix doses.
Preparation process (1)-(5) are with embodiment 1, to the whole grain of total mixture particle in the step (6) back packing is made granule.
Embodiment 3
Prescription: 30 parts of Calcium Ascorbates, 30 parts in calcium chloride, 5 parts in Marine fishbone collagen oligopeptide powder, 12 parts of aminoglucose hydrochlorides, 4 parts of CPPs, 6 parts in natural VE powder, 6 parts of vitamin Cs, vitamin K
10.04 part in powder, Cobastab
120.0001 part, vitamin D
30.00015 part in powder, 3.2 parts of dietary fibers, 2 parts in dextrin, 1 part in sweet mellow wine, 2.1 parts of Ac-Di-Sols, 0.3 part of superfine silica gel powder, 30 1.3 parts of 30 POVIDONE K 30 BP/USPs, 3 parts of stomach dissolved film coating pre-mix doses.
Preparation process (1)-(5) are with embodiment 1, to the whole grain of total mixture particle in the step (6) back packing is made granule.
Embodiment 4
Prescription: 70 parts of calcium gluconaes, 10 parts in calcium carbonate, 15 parts in Marine fishbone collagen oligopeptide powder, 9 parts of aminoglucose hydrochlorides, 6 parts of CPPs, 7 parts in natural VE powder, 1 part of vitamin C, vitamin K
10.05 part in powder, Cobastab
120.00008 part, vitamin D
30.00009 part in powder, 20 parts of dietary fibers, 6.8 parts of lactose, 1 part of cross linked polyvinyl pyrrolidone, 1.0 parts of dolomols, 2 parts of Hydroxypropyl methylcelluloses, 3 parts of stomach dissolved film coating pre-mix doses.
The preparation method is with embodiment 1.
Embodiment 5
Prescription: 40 parts in calcium carbonate, 10 parts in Marine fishbone collagen oligopeptide powder, 30 parts of aminoglucose hydrochlorides, 10 parts of CPPs, 7.5 parts in natural VE powder, 8 parts of vitamin Cs, vitamin K
10.06 part in powder, Cobastab
120.00009 part, vitamin D
30.00015 part in powder, 15 parts of dietary fibers, 3.8 parts of microcrystalline celluloses, 3 parts of sodium carboxymethyl starches, 2 parts of talcum powder, 0.1 part of ethyl cellulose, 3 parts of stomach dissolved film coating pre-mix doses.
The preparation method is with embodiment 1.
Embodiment 6
Prescription: 50 parts in calcium carbonate, 20 parts in Marine fishbone collagen oligopeptide powder, 9 parts of aminoglucose hydrochlorides, 1 part of CPP, 4 parts in natural VE powder, 4 parts of vitamin Cs, vitamin K
10.08 part in powder, Cobastab
120.0005 part, vitamin D
30.0002 part in powder, 5.4 parts of dietary fibers, 1.5 parts of low-substituted hydroxypropyl celluloses, 0.5 part of lauryl sodium sulfate, 0.5 part of methylcellulose, 3 parts of stomach dissolved film coating pre-mix doses.
The preparation method is with embodiment 1.
Embodiment 7
Prescription: 40 parts in calcium carbonate, 2 parts in Marine fishbone collagen oligopeptide powder, 15 parts of aminoglucose hydrochlorides, 20 parts of CPPs, 0.25 part in natural VE powder, 4 parts of vitamin Cs, vitamin K
10.02 part in powder, Cobastab
120.0002 part, vitamin D
30.0001 part in powder, 10 parts of dietary fibers, 2.8 parts in dextrin, 3 parts of sodium carboxymethyl starches, 1.0 parts of dolomols, 30 0.1 parts of 30 POVIDONE K 30 BP/USPs, 3 parts of stomach dissolved film coating pre-mix doses.
The preparation method is with embodiment 1.
Embodiment 8
Prescription: 60 parts in calcium carbonate, 7 parts in Marine fishbone collagen oligopeptide powder, 11 parts of aminoglucose hydrochlorides, 4 parts of CPPs, 5 parts in natural VE powder, 15 parts of vitamin Cs, vitamin K
10.1 part in powder, Cobastab
120.00008 part, vitamin D
30.00012 part in powder, 2.5 parts of dietary fibers, 3 parts of sodium carboxymethyl starches, 1.0 parts of dolomols, 30 1.5 parts of 30 POVIDONE K 30 BP/USPs, 3 parts of stomach dissolved film coating pre-mix doses.
The preparation method is with embodiment 1.
Embodiment 9
Prescription: 40 parts in calcium carbonate, 10 parts in Marine fishbone collagen oligopeptide powder, 5 parts of aminoglucose hydrochlorides, 6 parts of CPPs, 10 parts in natural VE powder, 25 parts of vitamin Cs, vitamin K
10.02 part in powder, Cobastab
120.00008 part, vitamin D
30.00018 part in powder, 6 parts of dietary fibers, 6 parts in sweet mellow wine, 0.5 part of cross linked polyvinyl pyrrolidone, 0.5 part of dolomol, 1 part of hydroxypropyl cellulose, 3 parts of stomach dissolved film coating pre-mix doses.
The preparation method is with embodiment 1.
Can also save the granulation step in the step (2) among the preparation method of the present composition, make the powder of said composition.
The present invention can also process oral liquid according to conventional method.
Claims (9)
1. a composition that reduces bone-loss is characterized in that, it is processed by the component of following weight portion:
Calcium compound 30-80 part, Marine fishbone collagen oligopeptide powder 1-50 part, aminoglucose hydrochloride 5-30 part, CPP 1-20 part, natural VE powder 0.25-7.5 part, vitamin C 1.5-50 part, vitamin K
1Powder 0.02-0.1 part, Cobastab
120.00005-0.0005 part, vitamin D
3Powder 0.000075-0.0005 part, dietary fiber 1-20 part.
2. composition according to claim 1; It is characterized in that said calcium compound is at least a in calcium carbonate, calcium citrate, calcium gluconae, calcium lactate, calcium malate, Calcium Ascorbate, calcium monohydrogen phosphate, calcium dihydrogen phosphate, calcium acetate, calcium caseinate, calcium chloride, calcium citrate malate, calcium phosphate, calcium sulfate, calcium glycerophosphate or the amino acid chelated calcium.
3. composition according to claim 2 is characterized in that, the parts by weight of said each component are:
Calcium compound 40-60 part, Marine fishbone collagen oligopeptide powder 5-20 part, aminoglucose hydrochloride 8-20 part, CPP 4-10 part, natural VE powder 4-10 part, vitamin C 4-10 part, vitamin K
1Powder 0.02-0.05 part, Cobastab
120.00008-0.0001 part, vitamin D
3Powder 0.00009-0.0002 part, dietary fiber 2-8 part.
4. composition according to claim 3 is characterized in that, it also comprises the auxiliary material of following weight portion:
Diluent 0-40 part, disintegrant 0-10 part, lubricant 0.5-5 part, adhesive 0-5 part, coating agent 0-3 part.
5. health food according to claim 4 is characterized in that, the parts by weight of said auxiliary material are: diluent 4-10 part, disintegrant 1-5 part, lubricant 0.8-2 part, adhesive 0.5-3 part, coating agent 2-3 part.
6. composition according to claim 5 is characterized in that, said diluent is at least a in microcrystalline cellulose, pre-paying starch, lactose, dextrin, Icing Sugar or the sweet mellow wine; Said disintegrant is at least a in sodium carboxymethyl starch, cross linked polyvinyl pyrrolidone, low-substituted hydroxypropyl cellulose or the Ac-Di-Sol; Said lubricant is at least a in dolomol, superfine silica gel powder, lauryl sodium sulfate, talcum powder, hydrogenated vegetable oil, polyethylene glycols or the magnesium laurylsulfate; Said adhesive is at least a in distilled water, ethanol, starch slurry, sodium carboxymethylcellulose, hydroxypropyl cellulose, methylcellulose, ethyl cellulose, Hydroxypropyl methylcellulose or the 30 POVIDONE K 30 BP/USP 30; Said coating agent is a stomach dissolved film coating pre-mix dose.
7. one kind prepares like claim 1,2,3,4,5 or 6 described method for compositions, it is characterized in that it carries out as follows:
Take by weighing each component and auxiliary material by prescription, with said vitamin C, aminoglucose hydrochloride, vitamin K
1Powder, vitamin D
3Powder, Cobastab
12Sieve respectively, subsequent use;
Adhesive is made into the aqueous solution of mass concentration 8%, and is subsequent use;
Calcium compound, aminoglucose hydrochloride add the aqueous solution and process softwood respectively, granulate, and drying, whole grain makes calcium compound particle and aminoglucose hydrochloride particle;
With vitamin K
1Powder, Cobastab
12, vitamin D
3Powder and CPP shake on Highefficientpowersifter by the equivalent method of progressively increasing and sieve twice, and sieve number is 80 orders, and mixing makes mixture one;
With said mixture one and vitamin C, the natural VE powder sieve twice that on Highefficientpowersifter, shakes, mixing, sieve number is 40 orders, makes mixture two;
Prepared calcium compound particle, aminoglucose hydrochloride particle, Marine fishbone collagen oligopeptide powder, dietary fiber, diluent, disintegrant, lubricant and said mixture dual-purpose mixer among the step c were always mixed 30 minutes; Make the total mixture particle; With particle directly packing process granule, or encapsulatedly process capsule or its compressing tablet in tablet press machine made label;
Said coating agent is dissolved in the ethanol; Stir and add purified water after 10 minutes, stir and made coating solution in 45 minutes, the concentration of coating agent is 10% (W/W) in the said coating solution; Concentration of ethanol is 70%, and label described in the step f is put into the tablet that dressing machine dressing promptly makes health food.
8. preparation of compositions method according to claim 7 is characterized in that, the whole grain of the total mixture particle that makes among the step f is promptly got the granule of health food.
9. preparation of compositions method according to claim 8 is characterized in that, the total mixture granule filling capsule that makes among the step f is promptly got the capsule of health food.
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Effective date of registration: 20170705 Address after: 225300 No. 816, drug city road, Jiangsu, Taizhou Patentee after: Shijiazhuang Pharmaceutical Group Pharmaceutical (Taizhou) Co., Ltd. CHINO Address before: 225300 science building, No. 1 drug city road, Jiangsu, Taizhou Patentee before: JIANGSU TAINUO MEDICINE CO., LTD. |