CN107184960A - It is a kind of to be used to increase Bone gillg ammonia sugar-tablet of bone density and preparation method thereof - Google Patents
It is a kind of to be used to increase Bone gillg ammonia sugar-tablet of bone density and preparation method thereof Download PDFInfo
- Publication number
- CN107184960A CN107184960A CN201710359491.2A CN201710359491A CN107184960A CN 107184960 A CN107184960 A CN 107184960A CN 201710359491 A CN201710359491 A CN 201710359491A CN 107184960 A CN107184960 A CN 107184960A
- Authority
- CN
- China
- Prior art keywords
- powder
- parts
- mixed
- bone
- tablet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7008—Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/10—Carbonates; Bicarbonates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Marine Sciences & Fisheries (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Inorganic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
Abstract
It is used to increase the Bone gillg ammonia sugar-tablet of bone density the invention provides a kind of, is at least made up of following component：Calcium carbonate, D aminoglucose hydrochlorides, chondroitin sulfate, the oligomeric Gly-His-Lys of Marine fishbone collagen, CPP powder, vitamine D3, microcrystalline cellulose, dextrin, superfine silica gel powder, magnesium stearate, PVP K30, hydroxypropyl methyl cellulose, polyethylene glycol, talcum powder；The present invention also includes the preparation method of the Bone gillg ammonia sugar-tablet.Rationally, convenient to take, palatability is good, raw material sources are easy to get extensively, safe without toxic side effect for the scientific formulation that the present invention is provided；Preparation is simple, with low cost, it is easy to industrialized production.
Description
Technical field
The invention belongs to field of health care products, health products and its system particularly for osteoporosis, with increase bone density
Preparation Method.
Background technology
Osteoporosis is to be reduced to principal character with bone amount, and the microstructure of bone tissue changes, with the increase of bone fragility
With a kind of elevated systemic skeletal disease of risk of fractures degree, pregnant woman, old man and a variety of patients with chronic diseases are mainly in.According to endless
Full statistics, China's senile osteoporosis disease incidence of disease of more than 60 years old is about 59.89%, concurrent because of osteoporosis every year
The incidence of disease of fracture is about 9.6%, and has the trend increased year by year.It is predicted that China with osteoporosis patient (including
Bone amount is reduced) 84,000,000 are there are about, the 6.6% of total population is accounted for, by 2025, illness rate was up to 13.3%.
The content of the invention
Technical problem：In order to solve the problem of existing osteoporosis is occurred frequently, major part crowd is in the urgent need to increase bone
There is provided a kind of Bone gillg ammonia sugar-tablet for being used to increase bone density and preparation method thereof for the present situation of density..
Technical scheme：The present invention provides a kind of for increasing the Bone gillg ammonia sugar-tablet of bone density, and it is at least by with the following group
Part is made：Calcium carbonate, D-Glucosamine Hydrochloride, chondroitin sulfate, CPP powder, vitamine D3, microcrystalline cellulose
Element, dextrin, superfine silica gel powder, magnesium stearate, PVP K30, hydroxypropyl methyl cellulose, polyethylene glycol, PVP.
As a preferred embodiment, it is at least made up of the component of following parts by weight：200-250 parts of calcium carbonate, D- aminoglucoses
Sugared hydrochloride 80-100 parts, 10-50 parts of chondroitin sulfate, oligomeric Gly-His-Lys 150-200 parts of Marine fishbone collagen, CPP
10-20 parts of powder, 0.1-0.5 parts of vitamine D3,70-100 parts of microcrystalline cellulose, 50-80 parts of dextrin, 3-9 parts of superfine silica gel powder, firmly
1-5 parts of fatty acid magnesium, 10-20 parts of PVP K30,7-18 parts of hydroxypropyl methyl cellulose, 1-2 parts of polyethylene glycol, talcum powder 2-5
Part, wherein, the total amount sum of hydroxypropyl methyl cellulose, polyethylene glycol and talcum powder is 10-25 parts.
As further preferred：CPC >=90% in the chondroitin sulfate.
As further preferred：Oligopeptide >=75%, calcium >=400mg/kg in the oligomeric Gly-His-Lys of Marine fishbone collagen.
As further preferred：Protein >=80%, CPP >=18% in the CPP powder.
Present invention additionally comprises a kind of preparation for increasing the Bone gillg ammonia sugar-tablet of bone density described in any of the above-described
Method, it is comprised the steps of：
Step (1), after the oligomeric Gly-His-Lys of Marine fishbone collagen, D-Glucosamine Hydrochloride are crushed respectively, sieving；By carbon
Sour calcium, chondroitin sulfate, CPP powder, microcrystalline cellulose, dextrin, superfine silica gel powder, vitamine D3 sieve respectively；Weigh
Magnesium stearate, PVP K30, hydroxypropyl methyl cellulose, polyethylene glycol, talcum powder；
Step (2), mixed powder 1 is mixed to obtain by vitamine D3 and superfine silica gel powder；CPP powder is mixed with mixed powder 1
Close, obtain mixed powder 2；D-Glucosamine Hydrochloride, chondroitin sulfate, microcrystalline cellulose, dextrin and mixed powder 2 are mixed, obtained
Mixed powder 3；Calcium carbonate, the oligomeric Gly-His-Lys of Marine fishbone collagen and mixed powder 3 are mixed, total mixed powder is obtained；
Step (3), PVP K30 ethanol solution is added in total mixed powder, softwood is obtained；
Step (4), softwood is sieved, wet granular is obtained；
Step (5), wet granular is dried, and re-sieving obtains dry particl；
Step (6), magnesium stearate is mixed with dry particl, compound is obtained；
Step (7), by compound tabletting, obtains plain piece；
Step (8), hydroxypropyl methyl cellulose, polyethylene glycol, talcum powder are added in purified water, and coating solution is made, right
Plain piece is coated, and obtains tablet.
As a kind of preferred：The manufacturing process of mixed powder 1 is in step (2)：First take vitamin D3With the superfine silica gel powder of equivalent
Mixture is mixed to obtain, the superfine silica gel powder added with mixture equivalent, which is mixed, makes mixture increase weight, and repeats weightening step, until complete
The vitamin D of portion's amount3It is well mixed with superfine silica gel powder, obtain mixed powder 1；Wherein, when CPP powder and mixed powder 1 are mixed
Between be 5-10min；D-Glucosamine Hydrochloride, chondroitin sulfate, microcrystalline cellulose, dextrin and the incorporation time of mixed powder 2 are
15-20min；Calcium carbonate, the oligomeric Gly-His-Lys of Marine fishbone collagen and the incorporation time of mixed powder 3 are 30-40min.
As further preferred：It is according to claim 7 a kind of for increasing the Bone gillg ammonia sugar-tablet of bone density
Preparation method, it is characterised in that：PVP K30 ethanol solution is the 10wt% PVPs that 95% ethanol is prepared in step (3)
K30。
As further preferred：In step (4), softwood sieving is 40 mesh sieves；In step (5), by wet granular at 50-60 DEG C
Dry to moisture≤5%, cross 40 mesh sieves, obtain dry particl；In step (6), magnesium stearate is 5- with dry particl incorporation time
10min。
Beneficial effect：Rationally, convenient to take, palatability is good, raw material sources are easy to get extensively for the scientific formulation that the present invention is provided,
Safe without toxic side effect；Preparation is simple, with low cost, it is easy to industrialized production.
Brief description of the drawings
Fig. 1 is process flow diagram of the invention.
Embodiment
Beneficial effects of the present invention are expanded on further below by experiment, the present invention is expanded on further by embodiment.
This experimental raw source producer and model such as following table：
| Material name | Manufacturer |
| The oligomeric Gly-His-Lys of Marine fishbone collagen | Zhejiang Hai Shi bio tech ltd |
| Chondroitin sulfate | Shandong Yi Bao biological products Co., Ltd |
Embodiment 1
(1) after crushing 150 parts of the oligomeric Gly-His-Lys of Marine fishbone collagen, 80 parts of D-Glucosamine Hydrochloride respectively, 80 are crossed
Mesh sieve, is weighed standby；By 200 parts of calcium carbonate, 10 parts of chondroitin sulfate, 10 parts of CPP powder, 70 parts of microcrystalline cellulose,
50 parts of dextrin, 3 parts of superfine silica gel powder cross 80 mesh sieves respectively, by vitamin D30.10 part of mesh sieve of mistake 40, is weighed standby；Weigh stearic
Sour 1 part of magnesium, 10 parts of PVP K30,10 parts of coating powder are standby；
(2) the above-mentioned vitamin D weighed up is taken3Fine powder and the mixing of the superfine silica gel powder fine powder of equivalent, then take and mixed powder equivalent
Superfine silica gel powder fine powder be well mixed, so times amount increase, until all well mixed, color and luster is consistent, obtains mixed powder 1；By junket
Protein phosphatase polypeptide powder and fine powder mixes 5min with mixed powder 1, obtains mixed powder 2；By D-Glucosamine Hydrochloride fine powder, chondroitin sulfate
Plain fine powder, microcrystalline cellulose fine powder, dextrin fine powder and the mixing 15min of mixed powder 2, obtain mixed powder 3；By calcium carbonate fine powder, ocean
Fish bone collagen oligopeptide powder and fine powder, the mixing 30min of mixed powder 3, obtain total mixed powder；
(3) 10% PVP K30 ethanol solution of 95% ethanol preparation is added in total mixed powder, softwood is obtained；
(4) softwood is pelletized with 40 mesh sieves, obtains wet granular；
(5) wet granular is dried to moisture ＜ 5% at 50 DEG C, 40 mesh sieve whole grains obtain dry particl；
(6) magnesium stearate is mixed into 5min with dry particl, obtains mixture；
(7) by mixture tabletting, plain piece, 700mg/ pieces are obtained；
(8) coating powder is dissolved with purified water, is configured to coating solution, plain piece is coated, obtain coated tablet.
Embodiment 2
(1) after 172.5 parts of the oligomeric Gly-His-Lys of Marine fishbone collagen, 90 parts of D-Glucosamine Hydrochloride being crushed respectively, mistake
80 mesh sieves, are weighed standby；By 210 parts of calcium carbonate, 30 parts of chondroitin sulfate, 15 parts of CPP powder, microcrystalline cellulose
80.5 parts, 75.05 parts of dextrin, 6 parts of superfine silica gel powder cross 80 mesh sieves respectively, 0.45 part of mesh sieve of mistake 40 of vitamine D3 is weighed standby
With；Weigh 3 parts of magnesium stearate, 17.5 parts of PVP K30,21 parts of coating powder standby；
(2) the above-mentioned vitamine D3 fine powder weighed up and the superfine silica gel powder fine powder of equivalent are mixed, then taken and mixed powder equivalent
Superfine silica gel powder fine powder be well mixed, so times amount increase, until all well mixed, color and luster is consistent, obtains mixed powder 1；By junket
Protein phosphatase polypeptide powder and fine powder mixes 8min with mixed powder 1, obtains mixed powder 2；By D-Glucosamine Hydrochloride fine powder, chondroitin sulfate
Plain fine powder, microcrystalline cellulose fine powder, dextrin fine powder and the mixing 18min of mixed powder 2, obtain mixed powder 3；By calcium carbonate fine powder, ocean
Fish bone collagen oligopeptide powder and fine powder, the mixing 35min of mixed powder 3, obtain total mixed powder；
(3) 10% PVP K30 ethanol solution of 95% ethanol preparation is added in total mixed powder, softwood is obtained；
(4) softwood is pelletized with 40 mesh sieves, obtains wet granular；
(5) wet granular is dried to moisture ＜ 5% at 55 DEG C, 40 mesh sieve whole grains obtain dry particl；
(6) magnesium stearate is mixed into 8min with dry particl, obtains mixture；
(7) by mixture tabletting, plain piece, 700mg/ pieces are obtained；
(8) coating powder is dissolved with purified water, is configured to coating solution, plain piece is coated, obtain coated tablet.
Embodiment 3
(1) after crushing 200 parts of the oligomeric Gly-His-Lys of Marine fishbone collagen, 100 parts of D-Glucosamine Hydrochloride respectively, 80 are crossed
Mesh sieve, is weighed standby；By 250 parts of calcium carbonate, 50 parts of chondroitin sulfate, 20 parts of CPP powder, microcrystalline cellulose 100
Part, 80 parts of dextrin, 9 parts of superfine silica gel powder cross 80 mesh sieves respectively, by vitamin D30.5 part of mesh sieve of mistake 40, is weighed standby；Weigh hard
5 parts of fatty acid magnesium, 20 parts of PVP K30,25 parts of coating powder are standby；
(2) by the above-mentioned vitamin D weighed up3Fine powder and the mixing of the superfine silica gel powder fine powder of equivalent, then take and mixed powder equivalent
Superfine silica gel powder fine powder be well mixed, so times amount increase, until all well mixed, color and luster is consistent, obtains mixed powder 1；By junket
Protein phosphatase polypeptide powder and fine powder mixes 10min with mixed powder 1, obtains mixed powder 2；D-Glucosamine Hydrochloride fine powder, sulfuric acid is soft
Ossein fine powder, microcrystalline cellulose fine powder, dextrin fine powder and the mixing 20min of mixed powder 2, obtain mixed powder 3；By calcium carbonate fine powder, sea
Foreign fish bone collagen oligopeptide powder and fine powder, the mixing 40min of mixed powder 3, obtain total mixed powder；
(3) 10% PVP K30 ethanol solution of 95% ethanol preparation is added in total mixed powder, softwood is obtained；
(4) softwood is pelletized with 40 mesh sieves, obtains wet granular；
(5) wet granular is dried to moisture ＜ 5% at 60 DEG C, 40 mesh sieve whole grains obtain dry particl；
(6) magnesium stearate is mixed into 10min with dry particl, obtains mixture；
(7) by mixture tabletting, plain piece, 700mg/ pieces are obtained；
(8) coating powder is dissolved with purified water, is configured to coating solution, plain piece is coated, obtain coated tablet.
Comparative example 1
(1) after 90 parts of D-Glucosamine Hydrochloride is crushed respectively, 80 mesh sieves are crossed, are weighed standby；By calcium carbonate 210
Part, 15 parts of CPP powder, 80.5 parts of microcrystalline cellulose, 75.05 parts of dextrin, 6 parts of superfine silica gel powder cross 80 mesh sieves respectively, will
0.45 part of mesh sieve of mistake 40 of vitamine D3, is weighed standby；Weigh 3 parts of magnesium stearate, 17.5 parts of PVP K30,21 parts of coating powder
It is standby；
(2) the above-mentioned vitamine D3 fine powder weighed up and the superfine silica gel powder fine powder of equivalent are mixed, then taken and mixed powder equivalent
Superfine silica gel powder fine powder be well mixed, so times amount increase, until all well mixed, color and luster is consistent, obtains mixed powder 1；By junket
Protein phosphatase polypeptide powder and fine powder mixes 8min with mixed powder 1, obtains mixed powder 2；By D-Glucosamine Hydrochloride fine powder, microcrystalline cellulose
Plain fine powder, dextrin fine powder and the mixing 18min of mixed powder 2, obtain mixed powder 3；Calcium carbonate fine powder, mixed powder 3 are mixed into 35min, obtained
Total mixed powder；
(3) 10% PVP K30 ethanol solution of 95% ethanol preparation is added in total mixed powder, softwood is obtained；
(4) softwood is pelletized with 40 mesh sieves, obtains wet granular；
(5) wet granular is dried to moisture ＜ 5% at 55 DEG C, 40 mesh sieve whole grains obtain dry particl；
(6) magnesium stearate is mixed into 8min with dry particl, obtains mixture；
(7) by mixture tabletting, plain piece, 700mg/ pieces are obtained；
(8) coating powder is dissolved with purified water, is configured to coating solution, plain piece is coated, obtain coated tablet.
Comparative example 2
(1) by 210 parts of calcium carbonate, 30 parts of chondroitin sulfate, 15 parts of CPP powder, 80.5 parts of microcrystalline cellulose,
75.05 parts of dextrin, 6 parts of superfine silica gel powder cross 80 mesh sieves respectively, by 0.45 part of mesh sieve of mistake 40 of vitamine D3, weigh standby；Weigh hard
3 parts of fatty acid magnesium, 17.5 parts of PVP K30,21 parts of coating powder are standby；
(2) the above-mentioned vitamine D3 fine powder weighed up and the superfine silica gel powder fine powder of equivalent are mixed, then taken and mixed powder equivalent
Superfine silica gel powder fine powder be well mixed, so times amount increase, until all well mixed, color and luster is consistent, obtains mixed powder 1；By junket
Protein phosphatase polypeptide powder and fine powder mixes 8min with mixed powder 1, obtains mixed powder 2；By chondroitin sulfate fine powder, microcrystalline cellulose fine powder,
Dextrin fine powder and the mixing 18min of mixed powder 2, obtain mixed powder 3；Calcium carbonate fine powder, mixed powder 3 are mixed into 35min, obtains and always mixes
Powder；
(3) 10% PVP K30 ethanol solution of 95% ethanol preparation is added in total mixed powder, softwood is obtained；
(4) softwood is pelletized with 40 mesh sieves, obtains wet granular；
(5) wet granular is dried to moisture ＜ 5% at 55 DEG C, 40 mesh sieve whole grains obtain dry particl；
(6) magnesium stearate is mixed into 8min with dry particl, obtains mixture；
(7) by mixture tabletting, plain piece, 700mg/ pieces are obtained；
(8) coating powder is dissolved with purified water, is configured to coating solution, plain piece is coated, obtain coated tablet.
Comparative example 3
(1) by after the 200 parts of crushing of the oligomeric Gly-His-Lys of Marine fishbone collagen, 80 mesh sieves is crossed, are weighed standby；By 250 parts of calcium carbonate,
20 parts of CPP powder, 100 parts of microcrystalline cellulose, 80 parts of dextrin, 9 parts of superfine silica gel powder cross 80 mesh sieves respectively, by vitamin
D30.5 part of mesh sieve of mistake 40, is weighed standby；Weigh 5 parts of magnesium stearate, 20 parts of PVP K30,25 parts of coating powder standby；
(2) by the above-mentioned vitamin D weighed up3Fine powder and the mixing of the superfine silica gel powder fine powder of equivalent, then take and mixed powder equivalent
Superfine silica gel powder fine powder be well mixed, so times amount increase, until all well mixed, color and luster is consistent, obtains mixed powder 1；By junket
Protein phosphatase polypeptide powder and fine powder mixes 10min with mixed powder 1, obtains mixed powder 2；By microcrystalline cellulose fine powder, dextrin fine powder and mixing
Powder 2 mixes 20min, obtains mixed powder 3；Calcium carbonate fine powder, Marine fishbone collagen oligopeptide powder and fine powder, mixed powder 3 are mixed
40min, obtains total mixed powder；
(3) 10% PVP K30 ethanol solution of 95% ethanol preparation is added in total mixed powder, softwood is obtained；
(4) softwood is pelletized with 40 mesh sieves, obtains wet granular；
(5) wet granular is dried to moisture ＜ 5% at 60 DEG C, 40 mesh sieve whole grains obtain dry particl；
(6) magnesium stearate is mixed into 10min with dry particl, obtains mixture；
(7) by mixture tabletting, plain piece, 700mg/ pieces are obtained；
(8) coating powder is dissolved with purified water, is configured to coating solution, plain piece is coated, obtain coated tablet.
Calcium carbonate control group
(1) by 250 parts of calcium carbonate, 20 parts of CPP powder, 100 parts of microcrystalline cellulose, 80 parts of dextrin, superfine silica gel powder
9 parts are crossed 80 mesh sieves respectively, by vitamin D30.5 part of mesh sieve of mistake 40, is weighed standby；Weigh 5 parts of magnesium stearate, PVP K30
20 parts, 25 parts of coating powder it is standby；
(2) by the above-mentioned vitamin D weighed up3Fine powder and the mixing of the superfine silica gel powder fine powder of equivalent, then take and mixed powder equivalent
Superfine silica gel powder fine powder be well mixed, so times amount increase, until all well mixed, color and luster is consistent, obtains mixed powder 1；By junket
Protein phosphatase polypeptide powder and fine powder mixes 10min with mixed powder 1, obtains mixed powder 2；By microcrystalline cellulose fine powder, dextrin fine powder and mixing
Powder 2 mixes 20min, obtains mixed powder 3；Calcium carbonate fine powder, mixed powder 3 are mixed into 40min, total mixed powder is obtained；
(3) 10% PVP K30 ethanol solution of 95% ethanol preparation is added in total mixed powder, softwood is obtained；
(4) softwood is pelletized with 40 mesh sieves, obtains wet granular；
(5) wet granular is dried to moisture ＜ 5% at 60 DEG C, 40 mesh sieve whole grains obtain dry particl；
(6) magnesium stearate is mixed into 10min with dry particl, obtains mixture；
(7) by mixture tabletting, plain piece, 700mg/ pieces are obtained；
(8) coating powder is dissolved with purified water, is configured to coating solution, plain piece is coated, obtain coated tablet.
Pharmacodynamic experiment
The beneficial effect of product of the present invention is expanded on further below by way of animal experiment, these experiments are foundations
《Health food is examined and assessment technique specification》The evaluation test side of increase bone density in (Ministry of Public Health's version in 2003)
Method and carry out.
200 grams -220 grams of cleaning grade female Wistar rats, group is randomly divided into according to body weight：
Blank control group：During other group of medicine gavage, with distilled water gavage.
Calcium carbonate control group：The product of gavage calcium carbonate control group, 3 times a day, each 50mg/kg,
Comparative example 1-3 groups：The product of gavage comparative example 1-3 groups, 3 times a day, each 50mg/kg,
Embodiment 1-3 groups：The product of gavage embodiment 1-3 groups, 3 times a day, each 50mg/kg.
The rat that 8 groups of the above, in addition to blank control group, remaining every group daily using calcium intake as reference frame gavage calcium water
Flat equal drug dose.
Experiment periods 12 weeks, weigh weekly.The last femoral artery sacrificed by exsanguination animal of experiment, takes out right side femur, in 105 DEG C of bakings
In case, bake to constant weight, weigh bone weight.Fl bone density (g/cm is determined using DPX-L Dual-energy X-rays absorptionmetries2), using original
Sub- absorptiometry determines right femur calcium content.
*, P ＜ 0.01 are compared with control group
From table 1, blank control group rat femur dry weight is compared with other groups to be significantly reduced (P ＜ 0.01)；Carbonic acid
Calcium control group, Marine fishbone collagen oligopeptide control group, embodiment group, compared femur dry weight with blank control group and have increase, and
There is significant difference (P ＜ 0.01).Blank control group rat femur midpoint bone density is compared that there were significant differences with other groups (P ＜
0.01)；Calcium carbonate control group, Marine fishbone collagen oligopeptide control group, embodiment group, compared femur midpoint with blank control group
Bone density has increase, and has significant difference (P ＜ 0.01).
Claims (9)
1. a kind of be used to increase the Bone gillg ammonia sugar-tablet of bone density, it is characterised in that：At least it is made up of following component：Carbonic acid
Calcium, D-Glucosamine Hydrochloride, chondroitin sulfate, the oligomeric Gly-His-Lys of Marine fishbone collagen, CPP powder, vitamin
D3, microcrystalline cellulose, dextrin, superfine silica gel powder, magnesium stearate, PVP K30, hydroxypropyl methyl cellulose, polyethylene glycol, talcum
Powder.
2. it is according to claim 1 a kind of for increasing the Bone gillg ammonia sugar-tablet of bone density, it is characterised in that：At least by
The component of following parts by weight is made：200-250 parts of calcium carbonate, 80-100 parts of D-Glucosamine Hydrochloride, chondroitin sulfate 10-
50 parts, oligomeric Gly-His-Lys 150-200 parts of Marine fishbone collagen, 10-20 parts of CPP powder, 0.1-0.5 parts of vitamine D3,
70-100 parts of microcrystalline cellulose, 50-80 parts of dextrin, 3-9 parts of superfine silica gel powder, 1-5 parts of magnesium stearate, 10-20 parts of PVP K30,
7-18 parts of hydroxypropyl methyl cellulose, 1-2 parts of polyethylene glycol, 2-5 parts of talcum powder, wherein, hydroxypropyl methyl cellulose, poly- second two
The total amount sum of alcohol and talcum powder is 10-25 parts.
3. it is according to claim 1 a kind of for increasing the Bone gillg ammonia sugar-tablet of bone density, it is characterised in that：The sulphur
CPC >=90% in aching and limp ossein.
4. it is according to claim 1 a kind of for increasing the Bone gillg ammonia sugar-tablet of bone density, it is characterised in that：The sea
Oligopeptide >=75%, calcium >=400mg/kg in the foreign oligomeric Gly-His-Lys of fish bone collagen.
5. it is according to claim 1 a kind of for increasing the Bone gillg ammonia sugar-tablet of bone density, it is characterised in that：The junket
Protein >=80%, CPP >=18% in protein phosphatase Gly-His-Lys.
6. being used for according to any one of claim 1 to 5 increases the preparation method of the Bone gillg ammonia sugar-tablet of bone density, its
It is characterised by：Comprise the steps of：
Step (1), after the oligomeric Gly-His-Lys of Marine fishbone collagen, D-Glucosamine Hydrochloride are crushed respectively, sieving；By carbonic acid
Calcium, chondroitin sulfate, CPP powder, microcrystalline cellulose, dextrin, superfine silica gel powder, vitamine D3 sieve respectively；Weigh hard
Fatty acid magnesium, PVP K30, hydroxypropyl methyl cellulose, polyethylene glycol, talcum powder；
Step (2), mixed powder 1 is mixed to obtain by vitamine D3 and superfine silica gel powder；CPP powder is mixed with mixed powder 1,
Obtain mixed powder 2；D-Glucosamine Hydrochloride, chondroitin sulfate, microcrystalline cellulose, dextrin and mixed powder 2 are mixed, must be mixed
Powder 3；Calcium carbonate, the oligomeric Gly-His-Lys of Marine fishbone collagen and mixed powder 3 are mixed, total mixed powder is obtained；
Step (3), PVP K30 ethanol solution is added in total mixed powder, softwood is obtained；
Step (4), softwood is sieved, wet granular is obtained；
Step (5), wet granular is dried, and re-sieving obtains dry particl；
Step (6), magnesium stearate is mixed with dry particl, compound is obtained；
Step (7), by compound tabletting, obtains plain piece；
Step (8), hydroxypropyl methyl cellulose, poly- second two, talcum powder are added in purified water, coating solution is made, plain piece is entered
Row is coated, and obtains tablet.
7. a kind of preparation method for increasing the Bone gillg ammonia sugar-tablet of bone density according to claim 7, its feature
It is：The manufacturing process of mixed powder 1 is in step (2)：First take vitamin D3Mixture is mixed to obtain with the superfine silica gel powder of equivalent, then is added
The superfine silica gel powder entered with mixture equivalent, which is mixed, makes mixture increase weight, and repeats weightening step, until the vitamin D of whole amount3With
Superfine silica gel powder is well mixed, and obtains mixed powder 1；Wherein, CPP powder and the incorporation time of mixed powder 1 are 5-10min；D- ammonia
Base glucosamine salt hydrochlorate, chondroitin sulfate, microcrystalline cellulose, dextrin and the incorporation time of mixed powder 2 are 15-20min；Calcium carbonate,
The oligomeric Gly-His-Lys of Marine fishbone collagen and the incorporation time of mixed powder 3 are 30-40min.
8. a kind of preparation method for increasing the Bone gillg ammonia sugar-tablet of bone density according to claim 7, its feature
It is：PVP K30 ethanol solution is the 10wt% PVP K30s that 95% ethanol is prepared in step (3).
9. a kind of preparation method for increasing the Bone gillg ammonia sugar-tablet of bone density according to claim 7, its feature
It is：In step (4), softwood sieving is 40 mesh sieves；In step (5), wet granular is dried to moisture≤5%, mistake at 50-60 DEG C
40 mesh sieves, obtain dry particl；In step (6), magnesium stearate is 5-10min with dry particl incorporation time.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710359491.2A CN107184960A (en) | 2017-05-19 | 2017-05-19 | It is a kind of to be used to increase Bone gillg ammonia sugar-tablet of bone density and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710359491.2A CN107184960A (en) | 2017-05-19 | 2017-05-19 | It is a kind of to be used to increase Bone gillg ammonia sugar-tablet of bone density and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107184960A true CN107184960A (en) | 2017-09-22 |
Family
ID=59874777
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710359491.2A Pending CN107184960A (en) | 2017-05-19 | 2017-05-19 | It is a kind of to be used to increase Bone gillg ammonia sugar-tablet of bone density and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107184960A (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108685943A (en) * | 2018-07-19 | 2018-10-23 | 深圳极醇健康产业股份有限公司 | A kind of tablet and preparation method thereof increasing bone density |
| CN108785651A (en) * | 2018-07-06 | 2018-11-13 | 常同喜 | A kind of preparation method for the Bone gillg ammonia sugar-tablet increasing bone density |
| CN109394808A (en) * | 2018-12-05 | 2019-03-01 | 天津铸源健康科技集团有限公司 | A kind of ammonia sugar calcium piece and preparation method thereof increasing bone density |
| CN110680906A (en) * | 2019-11-12 | 2020-01-14 | 山东润德生物科技有限公司 | Glucosamine bone glue peptide calcium granules |
| CN110946994A (en) * | 2019-12-30 | 2020-04-03 | 东营广元生物科技股份有限公司 | Composition for increasing bone mineral density and preparation method thereof |
| CN111135284A (en) * | 2019-12-11 | 2020-05-12 | 武汉跃莱健康产业有限公司 | Composition for improving bone mineral density and preparation method and application thereof |
| CN112957448A (en) * | 2021-02-08 | 2021-06-15 | 宁波御坊堂生物科技有限公司 | Composition for increasing bone mineral density, health product and preparation method thereof |
| CN113598379A (en) * | 2021-08-11 | 2021-11-05 | 红华御康生物科技(江苏)股份有限公司 | Small molecular peptide multiple biological nutrient and preparation method thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102178933A (en) * | 2011-04-20 | 2011-09-14 | 威海康博尔生物药业有限公司 | Preparation for preventing and treating osteoporosis and osteoarthrosis |
| CN102178934A (en) * | 2011-04-20 | 2011-09-14 | 威海博力生物工程有限公司 | Preparation for increasing bone mineral density, preventing osteoarthrosis and enhancing immunity |
| CN102318835A (en) * | 2011-08-31 | 2012-01-18 | 石家庄中硕药业集团有限公司 | Composition for reducing bone loss and preparation method thereof |
| CN102552877A (en) * | 2011-12-15 | 2012-07-11 | 广东汤臣倍健生物科技股份有限公司 | Health-care preparation for improving osteoporosis and increasing bone density and preparation method thereof |
| CN104382005A (en) * | 2013-08-19 | 2015-03-04 | 宣城柏维力生物工程有限公司 | Glucosamine chondroitin collagen tablet and preparation method thereof |
| CN105054035A (en) * | 2015-08-23 | 2015-11-18 | 洛阳维尔健生物工程有限公司 | Health-care product capable of improving bone density and preparation method of health-care product |
-
2017
- 2017-05-19 CN CN201710359491.2A patent/CN107184960A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102178933A (en) * | 2011-04-20 | 2011-09-14 | 威海康博尔生物药业有限公司 | Preparation for preventing and treating osteoporosis and osteoarthrosis |
| CN102178934A (en) * | 2011-04-20 | 2011-09-14 | 威海博力生物工程有限公司 | Preparation for increasing bone mineral density, preventing osteoarthrosis and enhancing immunity |
| CN102318835A (en) * | 2011-08-31 | 2012-01-18 | 石家庄中硕药业集团有限公司 | Composition for reducing bone loss and preparation method thereof |
| CN102552877A (en) * | 2011-12-15 | 2012-07-11 | 广东汤臣倍健生物科技股份有限公司 | Health-care preparation for improving osteoporosis and increasing bone density and preparation method thereof |
| CN104382005A (en) * | 2013-08-19 | 2015-03-04 | 宣城柏维力生物工程有限公司 | Glucosamine chondroitin collagen tablet and preparation method thereof |
| CN105054035A (en) * | 2015-08-23 | 2015-11-18 | 洛阳维尔健生物工程有限公司 | Health-care product capable of improving bone density and preparation method of health-care product |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108785651A (en) * | 2018-07-06 | 2018-11-13 | 常同喜 | A kind of preparation method for the Bone gillg ammonia sugar-tablet increasing bone density |
| CN108685943A (en) * | 2018-07-19 | 2018-10-23 | 深圳极醇健康产业股份有限公司 | A kind of tablet and preparation method thereof increasing bone density |
| CN109394808A (en) * | 2018-12-05 | 2019-03-01 | 天津铸源健康科技集团有限公司 | A kind of ammonia sugar calcium piece and preparation method thereof increasing bone density |
| CN110680906A (en) * | 2019-11-12 | 2020-01-14 | 山东润德生物科技有限公司 | Glucosamine bone glue peptide calcium granules |
| CN110680906B (en) * | 2019-11-12 | 2020-10-09 | 山东润德生物科技有限公司 | Glucosamine bone glue peptide calcium granules |
| CN111135284A (en) * | 2019-12-11 | 2020-05-12 | 武汉跃莱健康产业有限公司 | Composition for improving bone mineral density and preparation method and application thereof |
| CN110946994A (en) * | 2019-12-30 | 2020-04-03 | 东营广元生物科技股份有限公司 | Composition for increasing bone mineral density and preparation method thereof |
| CN112957448A (en) * | 2021-02-08 | 2021-06-15 | 宁波御坊堂生物科技有限公司 | Composition for increasing bone mineral density, health product and preparation method thereof |
| CN113598379A (en) * | 2021-08-11 | 2021-11-05 | 红华御康生物科技(江苏)股份有限公司 | Small molecular peptide multiple biological nutrient and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107184960A (en) | It is a kind of to be used to increase Bone gillg ammonia sugar-tablet of bone density and preparation method thereof | |
| CN101248882B (en) | Nutrition food product with promoting health of bones and bone arthrosis | |
| CN101559218B (en) | Composition with function of increasing bone density | |
| CN102552877A (en) | Health-care preparation for improving osteoporosis and increasing bone density and preparation method thereof | |
| CN106235311A (en) | A kind of compositions promoting skeletal system health and application thereof | |
| CN101856114B (en) | Health food with bone intensity enhancing function and preparation method thereof | |
| CN102178933A (en) | Preparation for preventing and treating osteoporosis and osteoarthrosis | |
| CN102551045B (en) | Collagen calcium tablet | |
| CN101904866A (en) | Medicinal composition for treating osteoporosis and preparation method thereof | |
| CN106880839B (en) | Deer bone tablet and preparation method thereof | |
| CN102085356B (en) | Composition for increasing bone mineral density and preparation method thereof | |
| CN106729599A (en) | A kind of pharmaceutical composition for increasing bone density and its production and use | |
| CN106213492A (en) | A kind of lifter motion function also increases health-oriented products and the preparation method of bone density | |
| CN104605226A (en) | Healthcare product with function of increasing bone mineral density | |
| CN104510717B (en) | Olanzapine orally-disintegrating tablet and preparation method thereof | |
| CN105105143A (en) | Health-care food composition capable of increasing bone density, health-care food and preparation method | |
| CN1823764A (en) | Medicinal composition containing strontium fuminate and vitamin D | |
| CN1785427A (en) | Compound calcium preparation for astronaut | |
| CN105770850A (en) | Health care product for adjuvant treatment of osteoarticular diseases and preparation method of health care product | |
| CN110946994A (en) | Composition for increasing bone mineral density and preparation method thereof | |
| CN109364036A (en) | A kind of calcium carbonate D3Piece and preparation method thereof | |
| CN109464651A (en) | A kind of amelioration of disease induced by metabolic disorder in cartilage healthy food and composite medicine | |
| CN107029162A (en) | Pharmaceutical composition, preparation method and the preparation of enhancing development | |
| CN108685943A (en) | A kind of tablet and preparation method thereof increasing bone density | |
| CN102000110A (en) | Composition used for preventing or treating bone and joint diseases and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |