CN104382005A - Glucosamine chondroitin collagen tablet and preparation method thereof - Google Patents
Glucosamine chondroitin collagen tablet and preparation method thereof Download PDFInfo
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- CN104382005A CN104382005A CN201310359979.7A CN201310359979A CN104382005A CN 104382005 A CN104382005 A CN 104382005A CN 201310359979 A CN201310359979 A CN 201310359979A CN 104382005 A CN104382005 A CN 104382005A
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- collagen
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- calcium carbonate
- vitamine
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- 102000008186 Collagen Human genes 0.000 title claims abstract description 44
- 108010035532 Collagen Proteins 0.000 title claims abstract description 44
- 229920001436 collagen Polymers 0.000 title claims abstract description 44
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 title claims abstract description 29
- 229920002567 Chondroitin Polymers 0.000 title claims abstract description 15
- DLGJWSVWTWEWBJ-HGGSSLSASA-N chondroitin Chemical compound CC(O)=N[C@@H]1[C@H](O)O[C@H](CO)[C@H](O)[C@@H]1OC1[C@H](O)[C@H](O)C=C(C(O)=O)O1 DLGJWSVWTWEWBJ-HGGSSLSASA-N 0.000 title claims abstract description 15
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 title abstract description 7
- 229960002442 glucosamine Drugs 0.000 title abstract description 7
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims abstract description 42
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims abstract description 22
- 229920001287 Chondroitin sulfate Polymers 0.000 claims abstract description 22
- 229940059329 chondroitin sulfate Drugs 0.000 claims abstract description 22
- 229910000019 calcium carbonate Inorganic materials 0.000 claims abstract description 21
- 229920002472 Starch Polymers 0.000 claims abstract description 19
- 239000008107 starch Substances 0.000 claims abstract description 19
- 235000019698 starch Nutrition 0.000 claims abstract description 19
- 239000002994 raw material Substances 0.000 claims abstract description 17
- 238000002156 mixing Methods 0.000 claims abstract description 11
- 239000000463 material Substances 0.000 claims abstract description 10
- 239000002245 particle Substances 0.000 claims abstract description 8
- 238000001035 drying Methods 0.000 claims abstract description 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 32
- 229910052791 calcium Inorganic materials 0.000 claims description 32
- 239000011575 calcium Substances 0.000 claims description 32
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 20
- WIGIZIANZCJQQY-UHFFFAOYSA-N 4-ethyl-3-methyl-N-[2-[4-[[[(4-methylcyclohexyl)amino]-oxomethyl]sulfamoyl]phenyl]ethyl]-5-oxo-2H-pyrrole-1-carboxamide Chemical compound O=C1C(CC)=C(C)CN1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCC(C)CC2)C=C1 WIGIZIANZCJQQY-UHFFFAOYSA-N 0.000 claims description 19
- 239000011782 vitamin Substances 0.000 claims description 19
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims description 17
- 239000000203 mixture Substances 0.000 claims description 13
- 238000012856 packing Methods 0.000 claims description 12
- 229910021529 ammonia Inorganic materials 0.000 claims description 10
- 229960003563 calcium carbonate Drugs 0.000 claims description 9
- 239000011812 mixed powder Substances 0.000 claims description 9
- 239000011122 softwood Substances 0.000 claims description 9
- 235000020985 whole grains Nutrition 0.000 claims description 6
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 claims description 5
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 claims description 5
- 229960002591 hydroxyproline Drugs 0.000 claims description 5
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 claims description 5
- 206010013786 Dry skin Diseases 0.000 claims description 3
- 229960005188 collagen Drugs 0.000 claims description 3
- 239000008187 granular material Substances 0.000 claims description 3
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- 239000012535 impurity Substances 0.000 claims description 2
- 210000000988 bone and bone Anatomy 0.000 abstract description 42
- 208000001132 Osteoporosis Diseases 0.000 abstract description 23
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 abstract description 4
- 238000000034 method Methods 0.000 abstract description 3
- 235000005282 vitamin D3 Nutrition 0.000 abstract description 2
- 239000011647 vitamin D3 Substances 0.000 abstract description 2
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 abstract description 2
- 229940021056 vitamin d3 Drugs 0.000 abstract description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 abstract 2
- 239000004615 ingredient Substances 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 235000019359 magnesium stearate Nutrition 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 238000005453 pelletization Methods 0.000 abstract 1
- 238000007493 shaping process Methods 0.000 abstract 1
- 238000007873 sieving Methods 0.000 abstract 1
- 239000007779 soft material Substances 0.000 abstract 1
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- 230000037182 bone density Effects 0.000 description 20
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- 230000036541 health Effects 0.000 description 9
- 239000000047 product Substances 0.000 description 7
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- 229920002683 Glycosaminoglycan Polymers 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
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- 230000001009 osteoporotic effect Effects 0.000 description 4
- 239000013589 supplement Substances 0.000 description 4
- 208000010392 Bone Fractures Diseases 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
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- 108010048734 sclerotin Proteins 0.000 description 3
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 241000272525 Anas platyrhynchos Species 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 229930003316 Vitamin D Natural products 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
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- 229940079593 drug Drugs 0.000 description 2
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- 229910052588 hydroxylapatite Inorganic materials 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
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- 210000004409 osteocyte Anatomy 0.000 description 2
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
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- 150000003710 vitamin D derivatives Chemical class 0.000 description 2
- 229940046008 vitamin d Drugs 0.000 description 2
- 208000020084 Bone disease Diseases 0.000 description 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- 229920002101 Chitin Polymers 0.000 description 1
- 241001148782 Davallia Species 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 208000012659 Joint disease Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
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- 150000001413 amino acids Chemical class 0.000 description 1
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- 239000011230 binding agent Substances 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
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- 229910001424 calcium ion Inorganic materials 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
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- 239000002537 cosmetic Substances 0.000 description 1
- 238000001784 detoxification Methods 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- HBYOLNPZXLHVQA-UHFFFAOYSA-J dicalcium dicarbonate Chemical compound [Ca+2].[Ca+2].[O-]C([O-])=O.[O-]C([O-])=O HBYOLNPZXLHVQA-UHFFFAOYSA-J 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
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- 150000002632 lipids Chemical class 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
- A23L33/155—Vitamins A or D
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
- A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention discloses a glucosamine chondroitin collagen tablet which comprises raw materials and auxiliary materials. The raw materials contain the following ingredients, by weight, 175-185 parts of D-glucosamine hydrochloride, 195-205 parts of calcium carbonate, 80-90 parts of chondroitin sulfate, 55-65 parts of collagen and 0.4-0.5 part of vitamin D3. The auxiliary materials contain starch and magnesium stearate, and the total weight of the auxiliary materials is 170-180 parts. The invention also discloses a preparation method of the glucosamine chondroitin collagen tablet. The preparation method comprises steps as follows: receiving of raw materials, feeding, crushing, sieving, weighing, mixing, preparation of a soft material, pelletizing, drying, particle shaping, total blending, tabletting and the like. The glucosamine chondroitin collagen tablet provided by the invention is prepared by a scientific technological method according to a certain weight ratio. By the use of the glucosamine chondroitin collagen tablet, osteoporosis can be prevented and treated safely and effectively, and bone mineral density can be increased.
Description
Technical field
The present invention relates to a kind of health products of tablet, particularly a kind of ammonia sugar chondroitin collagen tablet and preparation method thereof.
Background technology
Along with the society entering aging population, the aged constantly increases, and osteoporosis serious threat the health of the elderly.。Osteoporosis is apt to occur in postmenopausal women and elderly men,
Also has rejuvenation trend now.Therefore prevention and early treatment alleviate the key of this present situation early, and now about replenish the calcium, treat osteoporotic various medicine and functional food emerge in an endless stream, but real curative effect allows of no optimist, and market demand has the product for the treatment of both principal and secondary aspect of disease.
Osteoporosis is a kind of low with bone amount, and bone micro-structure damages, and causes bone fragility to increase, and the general osteopathy of fracture for feature easily occurs.It is with the disease of skeletal system that bone strength declines, risk of bone fracture increases to feature that U.S. National Institutes in 2001 proposes osteoporosis, two main aspects of bone strength reaction bone, i.e. bone density and stock quality.Along with the continuous aging of world population, bone density reduces crowd's increasing number, and osteoporosis incidence raises, and becomes global hygienic issues.Bone density reduces the healthy and quality of the life that the osteoporosis that causes has had a strong impact on the elderly, and presents incidence and rise year by year, and the trend that the age reduces occurs.Greatly, except bringing serious health and menticide to individual, consequent huge medicine and expenses of surgical treatment, also bring heavy economy and burden on society for incidence of osteoporosis and harmfulness.Therefore how effectively to increase bone density, prevention of osteoporosis disease has become the problem of people's extensive concern.
Relevant expert reminds, and osteoporosis can be prevented, and taking measures ahead of time increases bone density, and prevention of osteoporosis runs off, osteoporosis is not occurred or occurs comparatively slight, will be conducive to middle-aged and old healthy greatly.
The medicine of anti-osteoporosis has multiple clinically, and its main mechanism is also different.Or to suppress bone information or based on promoting bone growing, also to have the medicine of some multiple action mechanism.The user of clinical application mostly is suffers from osteoporosis, and using dosage and the course for the treatment of need determine by patient profiles.
Domestic existing several treat osteoporotic Chinese patent drug, and majority has relief of symptoms, alleviates the curative effect of ostalgia.Chinese medicine about improving bone density, reduce the large-scale clinical research of risk of bone fracture and still lack, long-term efficacy and security need research further.
Summary of the invention
The object of this invention is to provide one safely and effectively can prevention and therapy osteoporotic ammonia sugar chondroitin collagen tablet and preparation method thereof.
For achieving the above object, the invention provides a kind of ammonia sugar chondroitin collagen tablet, comprise stock and adjunct, described raw material comprises component D-Glucosamine Hydrochloride 175-185 part of following weight portion, calcium carbonate 195-205 part, chondroitin sulfate 80-90 part, collagen 55-65 part, vitamine D3 0.4-0.5 part, described auxiliary material comprises starch and dolomol, and its weight summation is 170-180 part.
As the preferred technical solution of the present invention, described raw material comprises the component D-Glucosamine Hydrochloride 179 parts of following weight portion, 200 parts, calcium carbonate, chondroitin sulfate 85 parts, collagen 60 parts, vitamine D3 0.45 part, described auxiliary material comprises starch and dolomol, and its quality summation is 177.55 parts.
Wherein, the purity >99% of described D-Glucosamine Hydrochloride, the calcium content of described calcium carbonate is 40%, hydroxyproline content >=6% of described collagen, and described vitamine D3 impurity content is 0.25%.
Present invention also offers the preparation method of a kind of ammonia sugar chondroitin collagen tablet, comprise the following steps:
1) raw material is got: get in proportion and meet standard, all kinds of raw materials through being up to the standards, comprise D-Glucosamine Hydrochloride, calcium carbonate, chondroitin sulfate, collagen, vitamine D3, starch, dolomol;
2) feeding: after each supplementary material removes external packing, inner packing enters 300,000 grades of clean areas by logistics corridor;
3) pulverize, sieve, weigh: D-Glucosamine Hydrochloride, calcium carbonate, chondroitin sulfate are pulverized respectively, then 80 mesh sieves are crossed respectively, weigh for subsequent use by formula rate, collagen, vitamine D3, starch are crossed 80 mesh sieves, weigh for subsequent use by formula rate, dolomol is pressed formula rate and weigh for subsequent use;
4) mix: vitamine D3 being mixed with collagen equal increments, to mixing, obtaining mixed powder 1, then by mixed powder 1 and D-Glucosamine Hydrochloride, calcium carbonate, chondroitin sulfate, starch mixing 20min, obtain mixed powder 2;
5) softwood processed: prepare softwood, obtain softwood;
6) granulate: cross 20 mesh sieves, obtain wet granular;
7) dry, whole grain: 50 DEG C of dryings, to the whole grain of moisture < 5%, 20 mesh sieve, obtain dry particle;
8) always mix: by the dolomol mixing 5min of dry particle with formula rate, obtain mixture;
9) compressing tablet: 0.7g/ sheet, obtains plain sheet;
10) select: select away substandard product;
11) inner packing: 60 slices/bottle;
12) external packing;
13) check;
14) put in storage.
Pharmaceutical composition of the present invention or health products based on medical science to the research of osteoporosis mechanism and principle of reatment thereof; simultaneously according to pharmaceutical research achievement; the not only supplementary calcium that has filtered out promotes its absorption and the deposition in bone simultaneously; also protect the health of cartilage and bone matrix; thus effectively increasing bone density, each component of the functions such as prevention of osteoporosis disease generation, according to theory of medicine prescription; according to certain weight proportion, the process of science is used to be prepared from.
Calcium is one of the abundantest inorganic elements of people's in-vivo content, and account for 1.5% ~ 2.0% of body weight for humans, wherein 99% is present in bone and tooth.Bone is the calcium storage vault that human body one is huge, and the precipitation of calcium in bone is constantly carried out with dissolving, remains dynamic balance.In the meantime, human body needs to supplement a large amount of calcium from the external world, and be deposited in sclerotin with the form of bone calcium, be particularly stored in bone trabecula, bone is constantly increased, increase slightly, thicken, bone density increases, and bone hardness increases.After bone reaches peak density, increase bone calcium with the age and constantly lose, bone density reduces gradually.The calcium of lifelong q.s is taken in has positive impact to increase bone density, has certain effect to prevention of osteoporosis.
The present invention has increases the health care of bone density, can prevention and therapy osteoporosis safely and effectively, and increase bone density, instructions of taking and dose are oral, every day 2 times, each 3, and specification is 0.7g/ sheet × 60 slice/bottle.Its significant composition is that every 100g is containing D-Glucosamine Hydrochloride 25.3g, calcium 11.43g, hydroxyproline 0.5g, vitamin D 0.16mg.
Detailed description of the invention
The following detailed description of the preferred technical solution of the present invention.
Embodiment one
Formula: described raw material comprises D-Glucosamine Hydrochloride 177g, calcium carbonate 203g, chondroitin sulfate 82g, collagen 63g, vitamine D3 0.42g, and described auxiliary material comprises starch and dolomol, and its quality summation is 178g.
Each supplementary material is made 1000 (about 0.7g/ sheets) altogether above.
Embodiment two
Formula: described raw material comprises D-Glucosamine Hydrochloride 183g, calcium carbonate 197g, chondroitin sulfate 88g, collagen 57g, vitamine D3 0.48g, and described auxiliary material comprises starch and dolomol, and its quality summation is 172g.
Each supplementary material is made 1000 (about 0.7g/ sheets) altogether above.
Embodiment three
Formula: described raw material comprises D-Glucosamine Hydrochloride 179g, calcium carbonate 200g, chondroitin sulfate 85g, collagen 60g, vitamine D3 0.45g, and described auxiliary material comprises starch and dolomol, and its quality summation is 177.55g.
Each supplementary material is made 1000 (about 0.7g/ sheets) altogether above.
A preparation method for ammonia sugar chondroitin collagen tablet, comprises the following steps:
1) raw material is got: get in proportion and meet standard, all kinds of raw materials through being up to the standards, comprise D-Glucosamine Hydrochloride, calcium carbonate, chondroitin sulfate, collagen, vitamine D3, starch, dolomol;
2) feeding: after each supplementary material removes external packing, inner packing enters 300,000 grades of clean areas by logistics corridor;
3) pulverize, sieve, weigh: D-Glucosamine Hydrochloride, calcium carbonate, chondroitin sulfate are pulverized respectively, then 80 mesh sieves are crossed respectively, weigh for subsequent use by formula rate, collagen, vitamine D3, starch are crossed 80 mesh sieves, weigh for subsequent use by formula rate, dolomol is pressed formula rate and weigh for subsequent use;
4) mix: vitamine D3 being mixed with collagen equal increments, to mixing, obtaining mixed powder 1, then by mixed powder 1 and D-Glucosamine Hydrochloride, calcium carbonate, chondroitin sulfate, starch mixing 20min, obtain mixed powder 2;
5) softwood processed: prepare softwood, obtain softwood;
6) granulate: cross 20 mesh sieves, obtain wet granular;
7) dry, whole grain: 50 DEG C of dryings, to the whole grain of moisture < 5%, 20 mesh sieve, obtain dry particle;
8) always mix: by the dolomol mixing 5min of dry particle with formula rate, obtain mixture;
9) compressing tablet: 0.7g/ sheet, obtains plain sheet;
10) select: select away substandard product;
11) inner packing: 60 slices/bottle;
12) external packing;
13) check;
14) put in storage.
Pharmaceutical composition of the present invention or health products based on medical science to the research of osteoporosis mechanism and principle of reatment thereof; simultaneously according to pharmaceutical research achievement; the not only supplementary calcium that has filtered out promotes its absorption and the deposition in bone simultaneously; also protect the health of cartilage and bone matrix; thus effectively increasing bone density, each component of the functions such as prevention of osteoporosis disease generation, according to theory of medicine prescription; according to certain weight proportion, the process of science is used to be prepared from.
Calcium is one of the abundantest inorganic elements of people's in-vivo content, and account for 1.5% ~ 2.0% of body weight for humans, wherein 99% is present in bone and tooth.Bone is the calcium storage vault that human body one is huge, and the precipitation of calcium in bone is constantly carried out with dissolving, remains dynamic balance.In the meantime, human body needs to supplement a large amount of calcium from the external world, and be deposited in sclerotin with the form of bone calcium, be particularly stored in bone trabecula, bone is constantly increased, increase slightly, thicken, bone density increases, and bone hardness increases.After bone reaches peak density, increase bone calcium with the age and constantly lose, bone density reduces gradually.The calcium of lifelong q.s is taken in has positive impact to increase bone density, has certain effect to prevention of osteoporosis.
D-Glucosamine Hydrochloride: there is important physiological function to human body, participate in the removing toxic substances of liver kidney, play anti-inflammatory liver protection effect, good curative effect is had to treatment rheumatism joint inflammation and gastric ulcer, it is the primary raw material of synthetic antibiotic and cancer therapy drug, also can be applicable to food, in cosmetics and feed addictive.Aminoglucose hydrochloride is by natural chitin extraction, is a kind of marine biological preparation, can promotes the synthesis of human body mucopolysaccharide, improves the viscosity of knuckle synovia, can improve the metabolism of articular cartilage.
Calcium carbonate, as a kind of calcium agent, is the main source of calcium in the present invention.The kind in calcium source is a lot, and calcium carbonate calcium content is high, bioavilability better, have no side effect, be a kind of calcium source preferably.Mend calcium carbonate consistent with the effect of BIOLOGICAL CALCIUM, all can increase the bone density of disuse osteoporosis rat.
Chondroitin sulfate belongs to the one of mucopolysaccharide, has can promote Subchondral drilling, suppress new vessels, relax the curative effect such as pain, and with Glucosamine with the use of, there is pain relieving, promote effect of regenerating bone or cartilage, fundamentally can improve joint prob.Chondroitin sulfate has higher ion polarity, and this is significant for regulating the deposition of activity influence calcium ion in sclerotin of various cell in bone tissue; It also can be expressed and regenerating bone or cartilage by strengthening II collagen mRNA, promotes osteoblast proliferation and new bone formation, reaches the effect of the function increasing bone density.
Chondroitin sulfate has clarification lipid, improves body function of detoxification, the effect such as diuresis and analgesia.Very effective to Collagen illness, also effective to the dysacousis caused by streptomysin.Acidic mucopolysaccharide is one of endemic element in connective tissue matrix in organism, and chondroitin sulfate A (CSA) is the one of acidic mucopolysaccharide.Medically prevent and treat for coronary heart disease.Main application approach be as the medicine for the treatment of joint disease normal with Glucosamine with the use of, there is pain relieving, promote regenerating bone or cartilage, soften effect of bone, can from improving joint prob at all.Chondroitin sulfate, to the protection of bone, can prevent that bone is hardening to become fragile, and prevents calcification from aggravating, and make stiff bone recover pliability, have larger help to the recovery of osteoproliferation, hardening the becoming fragile that reduce of certain limit presents the bone contours of expansion state.
Collagen not only improves the toughness of bone, and also play the object of sticking calcium, articular cartilage is mainly made up of collagen.Rhizoma Drynariae extract refers to that the extract that rhizome of davallia dry rhizome obtains through alcohol extracting, effect are the strong bone of kidney tonifying, continuous wound of invigorating blood circulation.
Collagen is skeleton, the important composition composition especially in cartilaginous tissue.Collagen is full of the net of duck eye just as in bone, and it can keep will run off calcareous firmly here.Do not have this to be full of the net of duck eye, even if supplement excessive calcium, can be lost in vain yet.And the characteristic amino acid hydroxy-proline of collagen transports the instrument of calcium to osteocyte in blood plasma.Ossein in osteocyte is the binder of hydroxyapatite, and it and hydroxyapatite together constitute the main body of bone.And the speed that osteoporotic essence is synthetic bone collagen does not catch up with needs, in other words, the formation speed of new ossein morphs or aging speed lower than old ossein.Research shows, if lack collagen, supplements and many calcareously also cannot prevent osteoporosis, therefore, only have and take in enough collagens that can be combined with calcium, calcium just can be made comparatively fast to be digested and assimilated in vivo, and can reach skeletal sites faster and deposit.
Vitamine D3 has another name called Aminocotin, cholecalciferol, can the calcification of growth promoting effects and bone, promotes the absorption of calcium.
Starch has dispersion in water insoluble, water, 60 ~ 70 DEG C of swelling features.Be often used as diluent, adhesive, disintegrant, and can be used to prepare dextrin and starch slurry.
Dolomol is the light fine powder without grittiness of white, has soapy feeling with skin contact.This product is insoluble in water, ethanol or ether, is mainly used as lubricant, antiplastering aid, glidant.The granulation of special appropriate oil, extract medicament, the particle made has good mobility and compressibility.Glidant is used as in direct tablet compressing.Also can be used as filter aid, fining agent and drip infusion, and the suspending agent of liquid preparation, thickener.
The present invention has increases the health care of bone density, can prevention and therapy osteoporosis safely and effectively, and increase bone density, instructions of taking and dose are oral, every day 2 times, each 3, and specification is 0.7g/ sheet × 60 slice/bottle.Its significant composition is that every 100g is containing D-Glucosamine Hydrochloride 25.3g, calcium 11.43g, hydroxyproline 0.5g, vitamin D 0.16mg.
Claims (4)
1. an ammonia sugar chondroitin collagen tablet, it is characterized in that: comprise stock and adjunct, described raw material comprises component D-Glucosamine Hydrochloride 175-185 part of following weight portion, calcium carbonate 195-205 part, chondroitin sulfate 80-90 part, collagen 55-65 part, vitamine D3 0.4-0.5 part, described auxiliary material comprises starch and dolomol, and its weight summation is 170-180 part.
2. a kind of ammonia sugar chondroitin collagen tablet as claimed in claim 1, it is characterized in that: described raw material comprises the component D-Glucosamine Hydrochloride 179 parts of following weight portion, 200 parts, calcium carbonate, chondroitin sulfate 85 parts, collagen 60 parts, vitamine D3 0.45 part, described auxiliary material comprises starch and dolomol, and its quality summation is 177.55 parts.
3. a kind of ammonia sugar chondroitin collagen tablet as claimed in claim 1 or 2, it is characterized in that: the purity >99% of described D-Glucosamine Hydrochloride, the calcium content of described calcium carbonate is 40%, hydroxyproline content >=6% of described collagen, described vitamine D3 impurity content is 0.25%.
4. a preparation method for ammonia sugar chondroitin collagen tablet, is characterized in that comprising the following steps:
1) raw material is got: get in proportion and meet standard, all kinds of raw materials through being up to the standards, comprise D-Glucosamine Hydrochloride, calcium carbonate, chondroitin sulfate, collagen, vitamine D3, starch, dolomol;
2) feeding: after each supplementary material removes external packing, inner packing enters 300,000 grades of clean areas by logistics corridor;
3) pulverize, sieve, weigh: D-Glucosamine Hydrochloride, calcium carbonate, chondroitin sulfate are pulverized respectively, then 80 mesh sieves are crossed respectively, weigh for subsequent use by formula rate, collagen, vitamine D3, starch are crossed 80 mesh sieves, weigh for subsequent use by formula rate, dolomol is pressed formula rate and weigh for subsequent use;
4) mix: vitamine D3 being mixed with collagen equal increments, to mixing, obtaining mixed powder 1, then by mixed powder 1 and D-Glucosamine Hydrochloride, calcium carbonate, chondroitin sulfate, starch mixing 20min, obtain mixed powder 2;
5) softwood processed: prepare softwood, obtain softwood;
6) granulate: cross 20 mesh sieves, obtain wet granular;
7) dry, whole grain: 50 DEG C of dryings, to the whole grain of moisture < 5%, 20 mesh sieve, obtain dry particle;
8) always mix: by the dolomol mixing 5min of dry particle with formula rate, obtain mixture;
9) compressing tablet: 0.7g/ sheet, obtains plain sheet;
10) select: select away substandard product;
11) inner packing: 60 slices/bottle;
12) external packing;
13) check;
14) put in storage.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104886553A (en) * | 2015-04-30 | 2015-09-09 | 威海特伦斯生物工程有限公司 | A production method of a preparation for alleviating osteoporosis and increasing bone mineral density |
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| CN105942501A (en) * | 2016-05-03 | 2016-09-21 | 宣城柏维力生物工程有限公司 | Tablets capable of increasing bone density and preparation method of tablets |
| CN106138085A (en) * | 2015-03-25 | 2016-11-23 | 烟台宝备生物技术有限公司 | A kind of have medicine or the health food increasing bone density effect |
| CN107184960A (en) * | 2017-05-19 | 2017-09-22 | 江苏江大五棵松生物科技有限公司 | It is a kind of to be used to increase Bone gillg ammonia sugar-tablet of bone density and preparation method thereof |
| CN108902987A (en) * | 2018-06-19 | 2018-11-30 | 北京中健天行医药科技有限公司 | Newborn mineral salt ammonia sugar chondroitin ties up D capsule |
| CN115804451A (en) * | 2022-11-25 | 2023-03-17 | 广州欣盛通健康管理科技有限公司 | Composition beneficial to increase of bone density and application of composition in food |
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- 2013-08-19 CN CN201310359979.7A patent/CN104382005A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106138085A (en) * | 2015-03-25 | 2016-11-23 | 烟台宝备生物技术有限公司 | A kind of have medicine or the health food increasing bone density effect |
| CN104886553A (en) * | 2015-04-30 | 2015-09-09 | 威海特伦斯生物工程有限公司 | A production method of a preparation for alleviating osteoporosis and increasing bone mineral density |
| CN105770850A (en) * | 2016-04-25 | 2016-07-20 | 南京邦康生物技术有限公司 | Health care product for adjuvant treatment of osteoarticular diseases and preparation method of health care product |
| CN105942501A (en) * | 2016-05-03 | 2016-09-21 | 宣城柏维力生物工程有限公司 | Tablets capable of increasing bone density and preparation method of tablets |
| CN107184960A (en) * | 2017-05-19 | 2017-09-22 | 江苏江大五棵松生物科技有限公司 | It is a kind of to be used to increase Bone gillg ammonia sugar-tablet of bone density and preparation method thereof |
| CN108902987A (en) * | 2018-06-19 | 2018-11-30 | 北京中健天行医药科技有限公司 | Newborn mineral salt ammonia sugar chondroitin ties up D capsule |
| CN115804451A (en) * | 2022-11-25 | 2023-03-17 | 广州欣盛通健康管理科技有限公司 | Composition beneficial to increase of bone density and application of composition in food |
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Application publication date: 20150304 |