CN100509028C - Purge capsules for old person and production thereof - Google Patents
Purge capsules for old person and production thereof Download PDFInfo
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- CN100509028C CN100509028C CNB2005101054616A CN200510105461A CN100509028C CN 100509028 C CN100509028 C CN 100509028C CN B2005101054616 A CNB2005101054616 A CN B2005101054616A CN 200510105461 A CN200510105461 A CN 200510105461A CN 100509028 C CN100509028 C CN 100509028C
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- radix angelicae
- angelicae sinensis
- constipation
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Abstract
A Chinese medicine in the form of capsule for treating the constipation of old man is proportionally prepared from aloe extract, Chinese angelica root and arctium fruit. Its preparing process is also disclosed.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, relate in particular to a kind of Chinese patent medicine for the treatment of constipation and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Constipation is meant that defecation frequency reduces, every 2-3 days or longer time once, irregularities, excrement matter is stiff, often with the difficult defecation sense, is a kind of clinical common symptom, constipation can be divided into acute and chronic two classes.The old people, often sit motionless white collar class, driver, fat person, the crowd that quantity of motion is few are the group of people at high risks of constipation, and according to statistics, nearly about 30% old people suffers from the different constipation of light and heavy degree.Constipation also easily causes multiple disease, and anal and intestinal diseases such as hemorrhage due to anal fissure, hemorrhoid, hemorrhoid complicated by anal fistula for example, are vowed gas at stomachache, headache, aching pain in should and back, and skin is coarse, facial freckle, black speck, urticaria, asthma etc.There are heart disease or hypertensive patient to bring out scheming infarction, apoplexy etc., also can cause symptoms such as endocrine disturbance, irritability by constipation.
The medicine of the treatment constipation of using clinically has at present: osmotic laxative, irritant laxative, emollient laxative, permeability caccagogue, dynamics-promoting medicine and 5-HT4 receptor stimulating agent etc.Osmotic laxative is also referred to as Epsom salts, because of it is not absorbed by intestinal wall and water-soluble, so can absorb large quantity of moisture in intestinal, the capacity of stool is increased, and plays the catharsis effect.The main representative medicine of such cathartic is a magnesium sulfate.But because it can not make colon tension force increase, so should not be used for the slow patient of those intestinal movements.The irritant laxative effect is fast, renders a service by force, and medicine or its metabolic product can produce stimulation to intestinal wall, and enterokinesia is increased.Such medicine mainly contains: phenolphthalein, Oleum Ricini, Radix Et Rhizoma Rhei, Folium Sennae etc.But be noted that this type of medicine because stimulate intestinal mucosa and intestinal wall plexus nervorum, and may cause the large intestine myasthenia, form drug dependence, thereby be mainly used in the stool incarceration and need rapid relieving constipation person, unsuitable prolonged application.Emollient laxative claims stool softener again, and the major function of this type of medicine is lubricated intestinal wall, and softening stool makes and is convenient to greatly discharge, as liquid paraffin etc.The main shortcoming of this class medicine is that mouthfeel is poor, and a little less than the effect, prolonged application can cause fatsoluble vitamin malabsorption.The permeability caccagogue, as lactulose, it is not absorbed by the body, and works at colon by discharging organic acid after the bacterial decomposition, especially is suitable for old people, pregnant and lying-in women, child and postoperative constipation person, the careful usefulness of diabetic.The major defect of this type of medicine is to produce gas at the bacterial action bottom fermentation, causes senses of discomfort such as abdominal distention.Above-mentioned these medicines are defectives such as having that curative effect is definite inadequately, toxic and side effects is big, should not take for a long time in various degree, preparation cost height all.
Summary of the invention
The technical problem that the present invention mainly solves is to overcome the deficiencies in the prior art, a kind of determined curative effect is provided, has no side effect, and is particularly suitable for the pharmaceutical composition of the treatment constipation that the old people takes for a long time.
The technical problem that the present invention mainly solves realizes by following technological approaches:
A kind of pharmaceutical composition for the treatment of constipation comprises by following bulk drugs and making:
Aloe extract 20-30 part, Radix Angelicae Sinensis 20-30 part, Fructus Arctii 20-30 part.
Preferably, pharmaceutical composition of the present invention is made by following bulk drugs:
25 parts of Aloe extracts, 25 parts of Radix Angelicae Sinensis, 25 parts of Fructus Arctiis.
In order to reach better therapeutic effect, aforementioned pharmaceutical compositions also can contain following bulk drugs: Herba Cistanches 20-30 part.
Preferred, the weight portion of each crude drug of pharmaceutical composition of the present invention is: 25 parts of Aloe extracts, 25 parts of Radix Angelicae Sinensis, 25 parts of Fructus Arctiis, 25 parts of Herba Cistanches.
Aloe: hardship, cold; Effect with heat clearing away, relieving constipation, parasite killing is monarch drug in we.
Radix Angelicae Sinensis: Gan Xin, temperature; Having that benefiting blood and regulating blood circulation, menstruction regulating and pain relieving are moisturized, the effect of laxation, is ministerial drug in we.
Fructus Arctii: arduous, cold; Effect with dispelling wind and heat pathogens, lung qi dispersing rash, subduing swelling and detoxicating is adjuvant in we.。
Herba Cistanches: sweet acid is salty, temperature, have the kidney invigorating, benefit smart, moisturize, the effect of laxation, in we, can assist the effect that improves curative effect of playing.
Above-mentioned all medicine compatibilities together, the property of medicine is gentle, cold not dry, each compatibility of drugs complements each other, and can regulate the intestinal wall blood circulation, promotes enterokinesia, plays the effect of intestine moistening defecation, toxin expelling, skin care, diseases prevention altogether.
The used crude drug of the present invention (annotate: used " Aloe extract " of the present invention bought when the Chinese medicine shop, and its trade name is " Aloe ") all can be bought from common Chinese medicine shop and obtain, and its specification meets unification of the motherland medicine standard.
Pharmaceutical composition of the present invention adds various conventional adjuvant required when preparing different dosage form, for example disintegrating agent, lubricant, adhesive etc., method of Chinese medicinal with routine can be prepared into any suitable oral formulations, can be pill, capsule, tablet, powder or granule etc. for example, be preferably capsule.
Preferably, a kind of method for preparing pharmaceutical composition of the present invention, step is as follows:
1) takes by weighing each raw material by subordinate's weight portion: Aloe extract 20-30 part, Radix Angelicae Sinensis 20-30 part, Fructus Arctii 20-30 part;
2) Fructus Arctii was pulverized the 100-130 mesh sieve after with the little stir-fry of little fire, standby; Aloe extract, Radix Angelicae Sinensis are pulverized the back cross the 100-130 mesh sieve; Merge the drug powder after above-mentioned the sieving, incapsulate promptly.
Usage and consumption: the dosage of medicine of the present invention depends on concrete dosage form, factors such as patient's age, body weight, health status.As guidance: capsule, only obey a 1-2 grain (every 0.3g) every day 1 time.
The specific embodiment
Further describe the present invention by the following examples, it should be understood that these embodiment only are used for the purpose of illustration, never limit the scope of the invention.
[embodiment 1] capsular preparation
By following weight take by weighing each raw material (unit: g):
Aloe extract (available from common Chinese medicine shop, its trade name is " Aloe ", the similar Colophonium of its profile) 25, Radix Angelicae Sinensis 25, Fructus Arctii 25; Fructus Arctii was pulverized 130 mesh sieves after with the little stir-fry of little fire, standby; Aloe extract, Radix Angelicae Sinensis are pulverized the back cross the 100-130 mesh sieve; Merge the drug powder after above-mentioned the sieving, adorn capsule, every 0.3g No. 0 with capsule machine.
[embodiment 2] capsular preparation
Take by weighing each raw material (unit: g): Aloe extract 20, Radix Angelicae Sinensis 20, Fructus Arctii 30, Herba Cistanches 30 by following weight; Fructus Arctii was pulverized 130 mesh sieves after with the little stir-fry of little fire, standby; Herba Cistanches is selected, pulverized 100 mesh sieves after the section, oven dry, and is standby; Aloe extract, Radix Angelicae Sinensis are pulverized the back cross 100 mesh sieves; Merge the drug powder after above-mentioned the sieving, adorn capsule, every 0.3g No. 0 with capsule machine.
[embodiment 3] capsular preparation
By following weight take by weighing each raw material (unit: g):
Aloe extract 30, Radix Angelicae Sinensis 30, Fructus Arctii 20, Herba Cistanches 20; Fructus Arctii was pulverized 130 mesh sieves after with the little stir-fry of little fire, standby; Herba Cistanches is selected, pulverized 130 mesh sieves after the section, oven dry, and is standby; Aloe extract, Radix Angelicae Sinensis are pulverized the back cross the 100-130 mesh sieve; Merge the drug powder after above-mentioned the sieving, adorn capsule, every 0.3g No. 0 with capsule machine.
The clinical observation on the therapeutic effect test of [test example] medicine composite for curing constipation of the present invention
One, physical data
Accept out-patient's 126 examples for medical treatment, 10~95 years old age.Man's 58 examples, women 68 examples; Above patient is divided into treatment group and matched group at random, and wherein 72 examples are organized in treatment, 65 years old mean age; Matched group 54 examples, 63 years old mean age is from distribution situations such as two groups of ages, the course of disease, the state of an illness, no significant difference, P〉0.05.
Two, trial drug
For the reagent thing: the capsule that the embodiment of the invention 1 is prepared.
Positive control medicine: compound Aloe capsule.
Three, Therapeutic Method
The treatment group is with for the treatment of reagent thing, and is oral, one time 1,1 time on the one, 2 weeks were a course of treatment.
Matched group is treated with compound Aloe capsule, and is oral, one time 1,2 times on the one, 2 weeks were a course of treatment.
Four, curative effect determinate standard
1. clinical recovery: medication disappears with interior clinical symptoms and sign a course of treatment.
2. produce effects: medication obviously improves with interior symptom, Signs a course of treatment.
3. effective: medication makes moderate progress with interior symptom, sign a course of treatment.
4. invalid: medication does not have improvement with interior symptom and sign 1 course of treatment.
Four, observed result
Observed result sees Table 1.
The clinical observation on the therapeutic effect result of table 1 medicine composite for curing constipation of the present invention
Clinical observation on the therapeutic effect is the result show, pharmaceutical composition clinical treatment constipation determined curative effect of the present invention, and general curative effect is better than positive control medicine compound Aloe capsule, in using the process of Drug therapy of the present invention, do not find that untoward reaction such as any diarrhoea, stomachache, abdominal distention appear in patient, clinical drug safety has no side effect, and is particularly suitable for the senile constipation patient and takes for a long time.
Claims (9)
1. a pharmaceutical composition for the treatment of constipation comprises by following bulk drugs and making: Aloe extract 20-30 part, Radix Angelicae Sinensis 20-30 part, Fructus Arctii 20-30 part.
2. according to the pharmaceutical composition of claim 1, it is characterized in that the weight portion of each crude drug is: 25 parts of Aloe extracts, 25 parts of Radix Angelicae Sinensis, 25 parts of Fructus Arctiis.
3. according to the pharmaceutical composition of claim 1, it is characterized in that also containing following bulk drugs: Herba Cistanches 20-30 part.
4. according to pharmaceutical composition, it is characterized in that the weight portion of each crude drug is: 25 parts of Aloe extracts, 25 parts of Radix Angelicae Sinensis, 25 parts of Fructus Arctiis, 25 parts of Herba Cistanches according to claim 3.
5. according to the pharmaceutical composition of claim 1, it is characterized in that being prepared into clinical suitable oral formulations according to the Chinese medicine preparation conventional method.
6. according to the pharmaceutical composition of claim 5, it is characterized in that described oral formulations is capsule, pill, tablet, powder or granule.
7. according to the pharmaceutical composition of claim 5, it is characterized in that described oral formulations is a capsule.
8. method for preparing the pharmaceutical composition for the treatment of constipation comprises:
1) takes by weighing each crude drug by following weight portion: Aloe extract 20-30 part, Radix Angelicae Sinensis 20-30 part, Fructus Arctii 20-30 part;
2) Fructus Arctii was pulverized the 100-130 mesh sieve after with the little stir-fry of little fire, standby; Aloe extract, Radix Angelicae Sinensis are pulverized the back cross the 100-130 mesh sieve; Merge the drug powder after above-mentioned the sieving, incapsulate promptly.
9. the purposes of the described arbitrary pharmaceutical composition of claim 1-6 in the medicine of preparation treatment constipation.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CNB2005101054616A CN100509028C (en) | 2005-09-28 | 2005-09-28 | Purge capsules for old person and production thereof |
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CNB2005101054616A CN100509028C (en) | 2005-09-28 | 2005-09-28 | Purge capsules for old person and production thereof |
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CN1939494A CN1939494A (en) | 2007-04-04 |
CN100509028C true CN100509028C (en) | 2009-07-08 |
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CNB2005101054616A Expired - Fee Related CN100509028C (en) | 2005-09-28 | 2005-09-28 | Purge capsules for old person and production thereof |
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Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN102228600A (en) * | 2011-07-13 | 2011-11-02 | 洪庆广 | Traditional Chinese medicine for treating constipation |
CN105596606A (en) * | 2016-02-18 | 2016-05-25 | 季新玲 | Medicinal preparation used for treating constipation and application thereof |
CN108244650A (en) * | 2016-12-28 | 2018-07-06 | 兰州奇正生态健康品有限公司 | A kind of composition for improving constipation and preparation method thereof and purposes |
-
2005
- 2005-09-28 CN CNB2005101054616A patent/CN100509028C/en not_active Expired - Fee Related
Non-Patent Citations (2)
Title |
---|
蔡淦治疗老年习惯性便秘的经验. 林江,蔡淦.上海中医药杂志,第39卷第12期. 2005 |
蔡淦治疗老年习惯性便秘的经验. 林江,蔡淦.上海中医药杂志,第39卷第12期. 2005 * |
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