CN102631497B - Health care composition - Google Patents
Health care composition Download PDFInfo
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- CN102631497B CN102631497B CN2012101220813A CN201210122081A CN102631497B CN 102631497 B CN102631497 B CN 102631497B CN 2012101220813 A CN2012101220813 A CN 2012101220813A CN 201210122081 A CN201210122081 A CN 201210122081A CN 102631497 B CN102631497 B CN 102631497B
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- herba epimedii
- hippocampus
- blood
- radix ginseng
- stigma croci
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- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a health care composition comprising ginseng, crocus sativus, herba epimedii and hippocampus japonicus. The composition has the functions of treating impotence and relaxing tendons and activating collaterals.
Description
Technical field
The invention belongs to the Chinese medicine health care product field, particularly a kind of health composition for the treatment of sexual impotence and being of value to relaxing muscles and tendons and activating QI and blood in the collateral.
Background technology
Sexual impotence is common clinically male sexual disorder, refers to that when having libido to require, penis anorthosis or erection are not hard, thereby hinders sexual intercourse maybe can not finish sexual intercourse.This disease serious threat male's physical and mental health also is one of reason that causes male infertility, not only causes sizable psychology and physiological misery to the patient, and severe patient also may cause the breakdown of a family and become social problem.The reason that causes this symptom is more, is physiological on the one hand, is psychological on the one hand.The medicine for the treatment of sexual impotence is more at present, but most of curative effect is slow and undesirable, and side effect is bigger, is not suitable for taking for a long time, and the employing external used medicine is also arranged, but effective drug duration is short, can not meet the demands.
Bones and tendons injury pain Therapeutic Method clinically such as Shujin, fascia, muscle tendon are to adopt operation and expectant treatment.The route of administration of expectant treatment generally is by venous transfusion administration, intramuscular injection and oral medication, but this treatment and route of administration still have many unsatisfactory places, as operates on to injury of human heavily, and healing is slow, the expense height.Venous transfusion administration, intramuscular injection and oral medication all make the drug osmotic whole body, body local organ and the tissue lesions efficacy of a drug do not concentrated, and weak curative effect, and side effect such as allergy, gastrointestinal upset are arranged.Grain damage disease has become the infringement health of the masses, has a strong impact on commonly encountered diseases, the frequently-occurring disease of operate as normal and life.In recent years, sick development such as Chinese medicine bone injury, grain damage is very fast, evident in efficacy.Integrated application blood circulation promoting and blood stasis dispelling in clinical, enrich blood regulate the flow of vital energy, strong bone mends marrow, wind-damp dispelling, bone and muscle strengthening medicine set a broken bone disease, can obtain the effect of " promoting tissue regeneration by removing blood stasis " " benefiting essence and marrow ".This is to be determined by the exclusive performance of Chinese medicine, and diseases such as visible traditional medicine treatment grain wound, bone injury have unique advantage.
Summary of the invention
The present invention adopt the Chinese crude drug of four kinds of integration of edible and medicinal herbs to make a kind of compositions that has treatment sexual impotence effect and be of value to relaxing muscles and tendons and activating QI and blood in the collateral, and optional passing through is processed into the preparation that supplies peroral dosage form with said composition in order to remedy the deficiencies in the prior art.
The present invention is achieved through the following technical solutions:
A kind of health composition, be made up of the raw material of following parts by weight: the parts by weight of each component are: Radix Ginseng 3-60 part, Stigma Croci 3-55 part, Herba Epimedii 4-55 part, Hippocampus 4-60 part.Preferably, Radix Ginseng 5-35 part, Stigma Croci 4-30 part, Herba Epimedii 4-35 part, Hippocampus 5-35 part.
Preferably, the weight proportion of each component is: 60 parts of Radix Ginsengs, 55 parts of Stigma Crocis, 55 parts of Herba Epimedii, 60 parts of Hippocampus.
Preferably, the weight proportion of each component is: 3 parts of Radix Ginsengs, 3 parts of Stigma Crocis, 4 parts of Herba Epimedii, 4 parts of Hippocampus.
Preferably, the weight proportion of each component is: 35 parts of Radix Ginsengs, 30 parts of Stigma Crocis, 35 parts of Herba Epimedii, 5 parts of hippocampus 3s.
Above-mentioned each component is selected, clean, drain, pulverize, mix, and namely gets compositions.Or adopting the extracting method of this area routine that above-mentioned each component is extracted, the extracting solution drying is mixed, and namely gets compositions.
Compositions of the present invention can directly be pulverized or through the active component of the refining compositions as treatment of the extraction of the conventional extractive technique in this area such as decoction and alcohol sedimentation technique or ethanol extract from water precipitation.Described active component can be made various pharmaceutical formulations with pharmaceutically acceptable carrier or excipient composition, as is how granular tablet, granule, capsule, or oral liquid etc.According to using needs, compositions of the present invention also can be processed into slow releasing preparation or quick releasing formulation.Wherein said pharmaceutically acceptable carrier or excipient are selected according to different dosage forms.These used carriers or excipient can determine for the those of ordinary skill of pharmaceutical field.
Medicinal and the health properties of each component that the present invention adopts is:
Hippocampus: belong to net-rope, the Solenognathus order, the general name of Hippocampus animal belongs to bony fish.Hippocampus is the higher rare Chinese medicine of a kind of economic worth, contains aminoacid and protein, fatty acid, steroidal and inorganic elements.Its property is sweet, warm, go into liver, kidney channel, kidney invigorating and YANG supporting, regulating qi and activating blood is controlled sexual impotence, the enuresis, dyspnea due to deficiency, difficult labour, furuncle swelling toxin, and have medicinal functions such as building body, kidney invigorating and YANG supporting, relaxing muscles and tendons and activating QI and blood in the collateral, anti-inflammatory analgetic, tranquillizing and allaying excitement, relieving cough and asthma, particularly more effective for the neural disease for the treatment of.
Radix Ginseng: the general name for a kind of herbaceos perennial of the Umbellales Araliaceae Radix Ginseng Panax of family comprises Radix Ginseng Rubra, Radix Ginseng, Radix Panacis Quinquefolii (Radix Panacis Quinquefolii), Radix Glehniae, Radix Codonopsis and Radix Pseudostellariae etc.Radix Ginseng among the present invention comprises through processing and refines back Radix Ginseng extract, various forms in grinding descendant's pure extract powder or Radix Ginseng growth course.Sweet little hardship, warm in nature, go into spleen, lung meridian, strongly invigorating primordial QI promotes the production of body fluid admittedly take off, and calms the nerves.It is deficient to control impairment caused by overstrain, lack of appetite, and asthenia, food is told in regurgitation, the stool lingering diarrhea, empty cough with asthma is short, the spontaneous perspiration sudden collapse, palpitation with fear, forgetful, dizziness and headache, sexual impotence, frequent micturition is quenched one's thirst, woman uterine bleeding, children's's intermittent infantile convulsion, and prolonged deficiency is not multiple, the disease of all qi-blood-body fluid deficiencies.
Stigma Croci: involved in the present invention to Stigma Croci (claiming Stigma Croci, Stigma Croci again), be the perennial flowers of a kind of Liliales Iridaceae crocus.Stigma Croci among the present invention comprises crocein powder after grinding, obtains Stigma Croci extracts or croceous other processing forms by various processes.Stigma Croci is used for the treatment of the multiple chronic disease of human body clinically, by the effect of its blood circulation promoting and blood stasis dispelling, anti-inflammation, and enhancing body endurance, strengthen lymphproliferation response, improve body cell immunity and humoral immunization with this, play human functional activity of vital energy operation, the effect of balance human body negative and positive adjusted.
Herba Epimedii: the Herba Epimedii that arrives involved in the present invention can be Berberidaceae plant Herba Epimedii, arrow leaf Herba Epimedii, pubescence Herba Epimedii, or the dried leaves of Herba Epimedii.Herba Epimedii among the present invention is hidden Herba Epimedii powder, icariin, icariin I, the Herba Epimedii A etc. through refining that comprise after grinding.Herba Epimedii has kidney-replenishing, bone and muscle strengthening, and the effect of wind-damp dispelling can improve body's immunity; Can expand all blood vessels, improve microcirculation, increase blood flow, increase coronary flow.
In said composition, Hippocampus and Herba Epimedii are monarch drug, are mainly used in kidney invigorating and YANG supporting, the regulating QI of invigorating blood circulation, relaxing muscles and tendons and activating QI and blood in the collateral, anti-inflammatory analgetic, bone and muscle strengthening, wind-damp dispelling; Radix Ginseng, Stigma Croci are all ministerial drug, and the performance QI invigorating is enriched blood, the effect of the kidney invigorating and essence nourishing, balance human body negative and positive.The present invention treats sexual impotence, and with kidney invigorating and YANG supporting, to fill blood be the rule for the treatment of, all medicines share and gather the effect of the kidney invigorating and essence nourishing, the strong body of tonifying YANG, blood enriching and dryness moistening altogether, and the sexual impotence that causes at a variety of causes has good curing, health-care effect.Being used for the treatment of relaxing muscles and tendons and activating QI and blood in the collateral, mainly is the focus that is penetrated into body local organs, tissue by absorption, produces pharmacology, reaches that the regulating QI of invigorating blood circulation, Shujin are regulated the flow of vital energy, the purpose of nourshing blood and promoting blood circulation, relaxing muscles and tendons and activating QI and blood in the collateral.
Because four kinds of effective ingredient in the said composition all belong to the material of integration of edible and medicinal herbs, thereby said composition also can be used as nutrient and healthcare products, perhaps for the preparation of the purposes of nutrient and healthcare products.
Clinical observation:
1, the clinical observation treatment for the treatment of sexual impotence
(1) clinical data
The inventor carries out clinical observation treatment to 258 routine impotence patients in 2009 so far, wherein, and age 20-30 year, 45 examples; 31-40 year, 71 examples, 41-50 year, 55 examples, 51-60 year, 48 examples, more than 60 years old, 39 examples.Sexual impotence reason: sexual impotence 31 examples due to sexual impotence 39 examples due to sexual hypofunction (lowly) person 57 examples, nephropathy, hepatopathy, psychic impotence 43 examples, incretion sexual impotence 31 examples, psychogenic sexual impotence 34 examples, arteriosclerotic sexual impotence 15 examples, unknown cause sexual impotence 8 examples.
(2) Therapeutic Method
Compositions of the present invention, warm water is for oral administration, and three times on the one, each 3～6g, one after each meal.Calculate treatment time according to the conditions of patients weight, patients with mild was taken 3 months, and the severe case serve on 6 months.
(3) curative effect determinate standard
Cure: after the treatment phase, erection is greater than 90 degree, and success rate of sexual intercourse is more than or equal to 80%.
Produce effects: after the treatment phase, erection is greater than 90 degree, and success rate of sexual intercourse is more than or equal to 50%.
Effectively: after the treatment phase, the erection situation makes moderate progress,, success rate of sexual intercourse is more than or equal to 30%.
Invalid: every index does not all have improvement before and after the medication.
(4) clinical effectiveness
Clinical cure 206 examples (79.84%), produce effects 28 examples (10.85%), effective 15 examples (5.81%), invalid 9 examples (3.49%), total effective rate is 96.51%.
The present invention prepares simply, and good absorbing effect is evident in efficacy, has no side effect, and is safe, is conducive to sufferer and in time alleviates condition of illness.
2, be used for the observation treatment of clinical relaxing muscles and tendons and activating QI and blood in the collateral symptom
(1) diagnostic criteria
Acute jerk contused wound; Traumatic bone injury;
(2) clinical trial method
EXPERIMENTAL DESIGN: adopt own control, opening, multicenter to test.
Basic demand: the test case adopts inpatient and clinic case, the strict control of clinic case variable factor.
Medication: compositions of the present invention, warm water is for oral administration, and three times on the one, each 2～5g, one after each meal.Calculate treatment time according to the conditions of patients weight, took 3-6 month according to the traumatic condition weight.
(3) efficacy assessment standard
Cure: after the treatment phase, it is normal that functional activity recovers; Therapeutic index is more than or equal to 90%.
Produce effects: after the treatment phase, functional activity recovers substantially; Therapeutic index is more than or equal to 60%.
Effectively: after the treatment phase, functional activity has improvement, and therapeutic index is more than or equal to 30%.
Invalid: every index does not all have improvement before and after the medication, and therapeutic index is less than 30%.。
(4) physical data
Among the 520 routine qualified experimenters, acute jerk contused wound 258 examples, traumatic bone injury 262 examples, inpatient's 242 examples, outpatient's 278 examples; Male's 299 examples, women's 221 examples; Maximum 65 years old age, minimal ages 17 years old; Acute jerk contused wound average course of disease 1.85 ± 0.91 days, traumatic fracture average course of disease 2.35 ± 1.21 days.
(5) curative effect
Subordinate list 1: curative effect situation (unit: example)
(6) to the improvement effect of condition of illness sign
Each sees improvement after the comparison (check) of disease integration and the medication, disappearance situation before and after subordinate list 6 treatment:
(4) specific embodiment and embodiment
Embodiment 1-3: powder or water decoction
Embodiment 1:
Get Radix Ginseng 60 grams, Stigma Croci 55 grams, Herba Epimedii 55 grams, Hippocampus 60 grams, above-mentioned raw materials is cleaned up, drying is beaten powder and is mixed, and makes powder or water decoction.
Embodiment 2:
Get Radix Ginseng 3 grams, Stigma Croci 3 grams, Herba Epimedii 4 grams, Hippocampus 4 grams, above-mentioned raw materials is cleaned up, drying is beaten powder and is mixed, and makes powder or water decoction.
Embodiment 3:
Get Radix Ginseng 35 grams, Stigma Croci 30 grams, Herba Epimedii 35 grams, hippocampus 35 grams, above-mentioned raw materials is cleaned up, drying is beaten powder and is mixed, and makes powder or water decoction.
Embodiment 4: tablet
Get Radix Ginseng 8 grams, Stigma Croci 5 grams, Herba Epimedii 35 grams, Hippocampus 13 grams, above-mentioned raw materials is cleaned up, make tablet according to common process.
Embodiment 5: capsule
Get Radix Ginseng 9 grams, Stigma Croci 8 grams, Herba Epimedii 12 grams, hippocampus 36 grams, above-mentioned raw materials is cleaned up, make capsule according to common process.
Embodiment 6: the controlled release osmotic tablet
| Component | Weight or percentage by weight |
| Effective layer | Effective layer raw material weight (gram) |
| Radix Ginseng | 10 |
| Stigma Croci | 9 |
| Herba Epimedii | 21 |
| Hippocampus | 25 |
| Poly(ethylene oxide) | 35.1 |
| Pulvis Talci | 2.9 |
| Polyvinylpyrrolidone | 6.8 |
| Magnesium stearate | 3.2 |
| Dehydrated alcohol | In right amount |
| Push layer | Push layer raw material percentage rate (%) |
| Magnesium stearate | 0.81 |
| Poly(ethylene oxide) | 55.26 |
| Hydrocarbon third methylcellulose | 8.1 |
| Ferrum oxide | 0.8 |
| Sodium chloride | 38.5 |
| Yoshinox BHT | 0.07 |
| Dehydrated alcohol | In right amount |
| Water | In right amount |
| Semi-permeable wall | Semi-permeable wall raw material percentage rate (%) |
| Cellulose diacetate | 96.0 |
| Polyethylene glycol 6000-992 | 4.0 |
| Acetone: water (95: 5) cosolvent | In right amount |
Dispose above-mentioned preparation according to the following step:
1, the effectively preparation of layer mixture: Chinese medicine material (wearing into fine powder behind the cleaning-drying), poly(ethylene oxide) and polyvinylpyrrolidone joined in the planetary mixing drum mix, slowly join dehydrated alcohol in the raw materials mixed, and continue stirring and made wet granular in 15 minutes, then, by 20 mesh sieves, and carry out drying, again by 16 mesh sieves.Then granule is changed over to planetary-type mixer and mix, add magnesium stearate and Talcum simultaneously and lubricate.
2, the preparation of push layer mixture: at first, the hydrocarbon propyl methocel of a dissolving part in water, then butylation alkyl toluene is dissolved in dehydrated alcohol, hydrocarbon propyl methocel aqueous solution joined in the ethanol solution that contains butylation alkyl toluene stir, make adhesive solution.Will be by grinding the sodium chloride that 21 mesh sieves sieve; grind the ferrum oxide that 40 mesh sieves sieve, poly(ethylene oxide) and remaining hydrocarbon propyl methocel join in the tube of fluidised bed granulator, and link to each other with granulator; the beginning pelletize, then with the adhesive solution spray to powder.After solution spray finishes, with the bag of gained the Manufactured granular solid matter drying of clothing, and grind, sieve by 8 mesh sieves, granule is mixed, and adds an amount of stearic acid and do not lubricate with.
3, tabletting: effective layer mixture and push layer mixture are pressed into double-layer tablet at preparation sheet machine.Effectively layer mixture joins nib earlier, carries out precommpression, adds the push layer mixture then, is pressed into the dual layer arrangement sheet.
4, wrap one deck semi-permeable wall at the dual layer arrangement sheet, this wall mixture is made up of cellulose acetate and Polyethylene Glycol, this mixture is dissolved in acetone: to make 4% solution, in the coating machine, be sprayed on the double-layer tablet this mixture then and on every side in the cosolvent of water (95: 5).
5, then, by the exit passageway of semi-permeable wall two 30mil of brill (0.762mm), effective layer is connected with the surface of drug-supplying system, at 50 ℃, dry 48H removes remaining solvent and redundant moisture under 50% humidity.
Dissolving-out method:
1, instrument: USP method I type (changeing the basket method), 100rpm.
2, medium: 700ml S6F 1 hour, adds phosphate buffer to PH7.5,900ml then.
3, sample time: 1,2,4,8 and 12 hours
4, analytical method: high performance liquid chromatography.
The stripping parameter is as follows:
| Time (hour) | SGF/SIF stripping percentage rate |
| 1 | 29.3 |
| 2 | 34.1 |
| 4 | 53.6 |
| 8 | 78.5 |
| 12 | 92.1 |
Claims (6)
1. health composition is characterized in that said composition is made up of Radix Ginseng, Stigma Croci, Herba Epimedii and Hippocampus, and the parts by weight of each component are: Radix Ginseng 3-60 part, Stigma Croci 3-55 part, Herba Epimedii 4-55 part, Hippocampus 4-60 part.
2. compositions according to claim 1 is characterized in that the parts by weight of each component in the described compositions are: Radix Ginseng 5-35 part, Stigma Croci 4-30 part, Herba Epimedii 4-35 part, Hippocampus 5-35 part.
3. compositions according to claim 1 and 2 is characterized in that the Herba Epimedii in the described compositions is icariin.
4. compositions according to claim 1 is characterized in that described compositions is the preparation of peroral dosage form.
5. the described compositions of claim 1 is in the health product of preparation treatment sexual impotence or the purposes in the medicine.
6. the described compositions of claim 1 is of value to the health product of human body relaxing muscles and tendons and activating QI and blood in the collateral or the purposes in the medicine in preparation.
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| CN2012101220813A CN102631497B (en) | 2012-04-24 | 2012-04-24 | Health care composition |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102028870A (en) * | 2010-12-28 | 2011-04-27 | 熊克文 | Kidney-invigorating and loins-strengthening wine |
| CN102212446A (en) * | 2011-05-09 | 2011-10-12 | 成中方 | Physical strength strengthening health-care medicinal liquor capable of tonifying kidney, strengthening yang and enhancing immunity and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102028870A (en) * | 2010-12-28 | 2011-04-27 | 熊克文 | Kidney-invigorating and loins-strengthening wine |
| CN102212446A (en) * | 2011-05-09 | 2011-10-12 | 成中方 | Physical strength strengthening health-care medicinal liquor capable of tonifying kidney, strengthening yang and enhancing immunity and preparation method thereof |
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| Title |
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| 姚海扬.性保健的饮食略述.《东方食疗与保健》.2006,(第06期), |
| 性保健的饮食略述;姚海扬;《东方食疗与保健》;20060630(第06期);48-51 * |
| 汪小波等.轻度认知功能障碍的中医药研究进展.《江西中医药》.2011,第42卷(第08期), |
| 轻度认知功能障碍的中医药研究进展;汪小波等;《江西中医药》;20110831;第42卷(第08期);70-72 * |
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