CN100534487C - Medicine for treating osteoarthrosis caused by wind, cold and damp and preparation method thereof - Google Patents
Medicine for treating osteoarthrosis caused by wind, cold and damp and preparation method thereof Download PDFInfo
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- CN100534487C CN100534487C CNB2007100621257A CN200710062125A CN100534487C CN 100534487 C CN100534487 C CN 100534487C CN B2007100621257 A CNB2007100621257 A CN B2007100621257A CN 200710062125 A CN200710062125 A CN 200710062125A CN 100534487 C CN100534487 C CN 100534487C
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Abstract
The present invention relates to one kind of externally applied plaster for treating osteoarthrosis caused by wind, cold and damp. The plaster is prepared with clematis root, spatholubus stem, yam rhizome, large-leaf gentian root, ledebouriella root and other Chinese medicinal materials, and through alcohol extraction to obtain extracted solution, adding matrix and other steps. It has the functions of relaxing muscles and tendons, promoting blood circulation, dispersing blood clots, dispelling cold, eliminating wind and damp, etc. It is used in treating arthritis, protrusion of cervical intervertebral disc, protrusion of lumbar intervertebral disc, spur, sciatica, etc. and has high curative effect.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of joint disease, particularly relating to a kind of is the externally applied ointment of the joint disease that caused by the wind and cold dampness of the treatment of feedstock production with Chinese medicine.The invention still further relates to the preparation method of this medicine.
Background technology
The joint disease that the tradition traditional Chinese medical science will be caused by the gas of the wet six climate exopathogens of wind and cold is referred to as " arthromyodynia ", arthromyodynia is a common frdquently encountered disease clinically, and the arthritis of modern medicine, scapulohumeral periarthritis, sciatica, cervical spondylosis, lumbar spondylosis, hyperosteogeny diseases all belong to the arthromyodynia category.Though it is a lot of to be used for this type of treatment of conditions medicine kind at present, defectives such as the ubiquity effect is single, weak curative effect, treatment cycle length can only be alleviated condition of illness to a certain extent, can not fundamentally cure.Doctor trained in Western medicine does not have specific short for this type of disease, and it is very big to the side effect of human body to take hormone medicines such as " prednisone ", " ibuprofen " for a long time.Chinese medicine for oral administration is also because liquor strength is low, absorbs slowly, and the disease place is driven out with wind-cold damp pathogen by the disease of can not going directly institute and drug effect is undesirable.Though methods such as acupuncture, cupping jar, massage have expended a large amount of time and energy, also can only alleviate condition of illness at short notice, can not thoroughly deal with problems.
Plaster is being brought into play important effect on the Chinese medicine development history, easy to use because of it, price is low, easily preserves, and treatment extensively is subjected to patient's welcome.The Chinese medicine plaster of treatment osteoarthritis is a feast for the eyes on the market now, but many plaster all can only play the effect of respite slight illness, do not reach the purpose for the treatment of both the principal and secondary aspects of a disease.Particularly the manufacture method of traditional black plaster is with Oleum Sesami used medicine to be exploded withered levitating earlier, remove assorted stain, be that thickening agent is shaped into cream again with Plumbum preparatium, there are a lot of defectives in the traditional manufacturing technique of this plaster, at first, the fried plurality of active ingredients that can destroy in the medicine of high temperature, can not reach the due therapeutic effect of medicine, secondly, be thickening agent with Plumbum preparatium, lead content in the plaster is higher, to the toxic effect of human body.
Summary of the invention
The purpose of this invention is to provide a kind of by pure Chinese medicine preparation, the treatment joint disease externally applied ointment of determined curative effect.
A kind of preparation method of above-mentioned plaster being provided, to overcome the traditional handicraft defective, reducing side effects of pharmaceutical drugs, strengthen the therapeutic effect of medicine, is another goal of the invention of the present invention.
Treatment joint disease medicine of the present invention is that crude drug prepares with following parts by weight of traditional Chinese medicines:
Radix Clematidis 8～10 Caulis Spatholobis 8～10
8～10 maos of Rhizoma Zingiberis Recens 4～8 of Rhizoma Dioscoreae Nipponicae
Radix Gentianae Macrophyllae 8～10 Radix Saposhnikoviaes 8～10
Ramulus Cinnamomi 8～10 Cortex Cinnamomis 2～5
Scorpio 2～5 Scolopendras 2～5
Zaocys 4～8 Holotrichia diomphalia Batess 2～5
Pheretima 2～5 Os Canitis 8～10
Radix Angelicae Sinensis 8～10 Rhizoma Chuanxiongs 4～8
Semen Persicae 4～8 Flos Carthamis 2～5
Radix Notoginseng 2～5 Semen Strychnis 4～8
Radix Aconiti 8～10 Radix Aconiti Kusnezoffii 8～10
Rhizoma Arisaematis 4～8 Olibanums 2～5
Myrrha 2～5.
The present invention is prepared into unguentum with above-mentioned Chinese medicine and uses, and its concrete preparation method is:
Said medicine is mixed according to described parts by weight, be ground into 60～80 purpose fineves, in the extractor of packing into, extract, filter and obtain extracting solution with 60～95% alcoholic solution that are equivalent to 2～4 times of fines weight; The extracting solution heating is concentrated, obtain concentrated extracting solution behind the recovery ethanol; With the concentrated extracting solution for preparing according to cream: medicine=1.5～2: 1 allotment ratio joins in prefabricated female cream, and mix homogeneously is divided and make plaster on non-woven fabrics.
Described female cream is mixed by 40 parts of polyisobutylene, 20 parts of Colophonium, 20 parts of osseocolla, 5 parts of Cera Flavas, 10 parts of glycerol and 5 parts of lanolines and obtains.
Wherein, described alcoholic solution extract operation be earlier with material 50～70 ℃ of preheatings 30～60 minutes, be warming up to 80～90 ℃ again, reflux, extract, 4～8 hours.
The present invention is under traditional Chinese medicine theory instructs, according to monarch, minister, the allotment outline helping, make, the allotment rule of treatment of mutual reinforcement between, the mutual-assistance, interpromoting relation in five elements, restriction or checking relation in five elements is according to conditions such as different sick positions, human righteousness's prosperity and decline, wind-cold damp pathogen deflections, select medicine to allocate meticulously, refining forming.Both embody the science of traditional Chinese medicine prescription, combined with modern Chinese medicine research again, had effects such as relaxing muscles and tendons to promote blood circulation, blood stasis dispelling cold expelling, wind-damp dispelling, hard masses softening and resolving, strengthening the tendons and bones.Can be used for treating the pain that rheumatism, osteoarthritis cause; The osteoarthrosis activity disorder that hyperosteogeny, bony spur cause; The waist that prolapse of lumbar intervertebral disc causes, have a pain in the leg the pain etc., symptoms such as the torpor and swelling that periosteum, muscular fasciae adhesion are caused, pain, swelling, stiffness and deforming have specially good effect, can remove the muscular fasciae adhesion rapidly, ease the pain, suppress joint deformity, recover the articular muscle function, thereby reach the purpose of rehabilitation health.
The present invention is in conjunction with modern biotechnology, replace the fried pharmacy material of traditional Oleum Sesami with solvent extraction technology, whole composition extractions of used medicine are collected, be dissolved in female cream, kept the integrity of medicine effective active composition, it is strong that the plaster of making oozes penetrating power, the utilization rate of active components height, not only the gas to the six climate exopathogens of anemofrigid-damp arthralgia has the effect of dispeling significantly, also has certain immunization.The present invention adopts advanced deleading technology, utilizes plant gum to allocate making meticulously as female cream, not leaded arsenic in the product, after can not produce harm to human body, have certain safety.
Now thorn, sciatica, lumbar muscle strain, scapulohumeral periarthritis, various bone matrix hyperplasia and the pressuring nerve pain that is caused by hypertrophy, numb disease etc. all have good curative effect to medicine of the present invention for treatment of arthritis, prolapse of cervical intervertebral disc, prolapse of lumbar intervertebral disc, sufficient bone.Ointment of the present invention directly is affixed on the affected part surface, and application is convenient, and treatment cycle is short.Medicine need not take orally, and effective ingredient is without gastrointestinal absorption, and can not produce digestive system stimulates, and therapeutic effect is good.
The present invention selects 683 routine patients to carry out clinical observation on the therapeutic effect altogether, to show the therapeutic effect of medicine external of the present invention for osteoarthritis.Among the 683 routine patients, male 315 people, women 368 people, the oldest 85 years old, minimum 12 years old, clinical diagnosis was rheumatic arthritis 281 examples, scapulohumeral periarthritis 196 examples, hyperosteogeny 128 examples, prolapse of lumbar intervertebral disc 35 examples, cervical spondylosis 43 examples.All use plaster outer plaster of the present invention affected parts to treat observation, using method is to change dressings 1 time in 3 days, and 3 to paste be a course of treatment.Criterion of therapeutical effect is: clinical symptoms and positive Signs all disappear after 1～3 course of treatment of treatment, and joint motion is normal, does not see in 1 year that recurrence is recovery from illness; Clinical symptoms disappeared substantially after smelting treated for 1～3 course of treatment, and only having a small amount of discomfort is produce effects; Clinical symptom relief after 1～3 course of treatment is treated in smelting, and a little is limited or the mild pain sense is often arranged for effectively for joint motion; Clinical symptoms is not seen and is alleviated to invalid.
Through using Drug therapy of the present invention after 1～3 course of treatment, cure various joint disease 241 examples, account for 35%, produce effects 265 examples account for 39%, and effective 138 examples account for 20%, and invalid 39 examples account for 6%, and total effective rate reaches 94%.
Table 1 683 routine wind-cold-dampness ache patient clinical efficacy tables
The specific embodiment
Embodiment 1
Get 4Kg polyisobutylene, 2Kg Colophonium, 2Kg osseocolla, 0.5Kg Cera Flava, 1Kg glycerol and 0.5Kg lanoline and mix, obtain preform carrier cream after stirring.
With Radix Clematidis 2700g, Caulis Spatholobi 2700g, Rhizoma Dioscoreae Nipponicae 2700g, hair Rhizoma Zingiberis Recens 1800g, Radix Gentianae Marcrophyllae 2700g, Radix Saposhnikoviae 2700g, Ramulus Cinnamomi 2700g, Cortex Cinnamomi 900g, Scorpio 900g, Scolopendra 900g, Zaocys 1800g, Holotrichia diomphalia Bates 900g, Pheretima 1350g, Os Canitis 3000g, Radix Angelicae Sinensis 2700g, Rhizoma Chuanxiong 1800g, Semen Persicae 1800g, Flos Carthami 1350g, Radix Notoginseng 900g, Semen Strychni 1800g, Radix Aconiti 2700g, Radix Aconiti Kusnezoffii 2700g, Rhizoma Arisaematis 2250g, Olibanum 1350g, Myrrha 1350g amounts to 48450g Chinese medicine mixed powder and is broken into 60 purpose fineves, pack in the extractor, add 80% alcoholic solution 150Kg, be warming up to 70 ℃ of preheatings 40 minutes, continue to be warming up to 90 ℃, heating and refluxing extraction 6 hours is filtered and is obtained extracting solution.The extracting solution heating is concentrated, obtain the 5Kg concentrated extracting solution behind the recovery ethanol.Get the female cream of 9Kg,, divide and on non-woven fabrics, make plaster with the concentrated extracting solution mix homogeneously.
Embodiment 2:
Prepare raw material (g) according to following weight
Radix Clematidis 100g Caulis Spatholobi 100g Rhizoma Dioscoreae Nipponicae 80g hair Rhizoma Zingiberis Recens 50g Radix Gentianae Marcrophyllae 100g
Radix Saposhnikoviae 100g Ramulus Cinnamomi 100g Cortex Cinnamomi 25g Scorpio 25g Scolopendra 25g
Zaocys 50g Holotrichia diomphalia Bates 25g Pheretima 25g Os Canitis 80g Radix Angelicae Sinensis 50g
Rhizoma Chuanxiong 50g Semen Persicae 40g Flos Carthami 25g Radix Notoginseng 25g Semen Strychni 50g
Radix Aconiti 100g Radix Aconiti Kusnezoffii 100g Rhizoma Arisaematis 60g Olibanum 30g Myrrha 30g
Above-mentioned 1445g Chinese medicine powder is broken into 80 purpose fineves, in the extractor of packing into, adds 60% alcoholic solution 5500g, be warming up to 60 ℃ of preheatings 60 minutes, continue to be warming up to 80 ℃, heating and refluxing extraction 8 hours is filtered and is obtained extracting solution.The extracting solution heating is concentrated, obtain the 150g concentrated extracting solution behind the recovery ethanol.Get the female cream of 300g,, divide and on non-woven fabrics, make plaster with the concentrated extracting solution mix homogeneously.
Embodiment 3
Radix Clematidis 80g Caulis Spatholobi 80g Rhizoma Dioscoreae Nipponicae 80g hair Rhizoma Zingiberis Recens 80g Radix Gentianae Marcrophyllae 80g
Radix Saposhnikoviae 80g Ramulus Cinnamomi 80g Cortex Cinnamomi 45g Scorpio 45g Scolopendra 45g
Zaocys 80g Holotrichia diomphalia Bates 45g Pheretima 45g Os Canitis 80g Radix Angelicae Sinensis 80g
Rhizoma Chuanxiong 80g Semen Persicae 80g Flos Carthami 45g Radix Notoginseng 45g Semen Strychni 80g
Radix Aconiti 80g Radix Aconiti Kusnezoffii 80g Rhizoma Arisaematis 80g Olibanum 45g Myrrha 45g
Above-mentioned 1685g Chinese medicine powder is broken into 80 purpose fineves, in the extractor of packing into, adds 95% alcoholic solution 4000g, be warming up to 50 ℃ of preheatings 30 minutes, continue to be warming up to 80 ℃, heating and refluxing extraction 5 hours is filtered and is obtained extracting solution.The extracting solution heating is concentrated, obtain the 120g concentrated extracting solution behind the recovery ethanol.Get the female cream of 200g,, divide and on non-woven fabrics, make plaster with the concentrated extracting solution mix homogeneously.
Claims (4)
1, a kind of medicine for the treatment of joint disease is characterized in that with following parts by weight of traditional Chinese medicines be crude drug, and it is prepared into unguentum:
Radix Clematidis 8～10 Caulis Spatholobis 8～10
8～10 maos of Rhizoma Zingiberis Recens 4～8 of Rhizoma Dioscoreae Nipponicae
Radix Gentianae Macrophyllae 8～10 Radix Saposhnikoviaes 8～10
Ramulus Cinnamomi 8～10 Cortex Cinnamomis 2～5
Scorpio 2～5 Scolopendras 2～5
Zaocys 4～8 Holotrichia diomphalia Batess 2～5
Pheretima 2～5 Os Canitis 8～10
Radix Angelicae Sinensis 8～10 Rhizoma Chuanxiongs 4～8
Semen Persicae 4～8 Flos Carthamis 2～5
Radix Notoginseng 2～5 Semen Strychnis 4～8
Radix Aconiti 8～10 Radix Aconiti Kusnezoffii 8～10
Rhizoma Arisaematis 4～8 Olibanums 2～5
Myrrha 2～5.
2, the preparation method of the described treatment joint disease of claim 1 medicine, it is characterized in that the above-mentioned raw materials medicine is mixed according to described parts by weight, be ground into 60～80 purpose fineves, in the extractor of packing into, 60～95% alcoholic solution with 2～4 times of fines weight extract, and filter and obtain extracting solution; The extracting solution heating is concentrated, obtain concentrated extracting solution behind the recovery ethanol; With the concentrated extracting solution for preparing according to female cream: concentrated extracting solution=1.5～2: 1 weight allotment ratio joins in prefabricated female cream, and mix homogeneously is divided and make plaster on non-woven fabrics.
3, the preparation method of treatment joint disease medicine according to claim 2 is characterized in that described female cream is mixed by 40 weight portion polyisobutylene, 20 weight portion Colophonium, 20 weight portion osseocolla, 5 weight portion Cera Flavas, 10 weight portion glycerol and 5 weight portion lanolines to obtain.
4, the preparation method of treatment joint disease medicine according to claim 2 is characterized in that it is first 50～70 ℃ of preheatings 30～60 minutes that described alcoholic solution extracts operation, is warming up to 80～90 ℃, reflux, extract, 4～8 hours again.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2007100621257A CN100534487C (en) | 2007-06-06 | 2007-06-06 | Medicine for treating osteoarthrosis caused by wind, cold and damp and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2007100621257A CN100534487C (en) | 2007-06-06 | 2007-06-06 | Medicine for treating osteoarthrosis caused by wind, cold and damp and preparation method thereof |
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| CN101066348A CN101066348A (en) | 2007-11-07 |
| CN100534487C true CN100534487C (en) | 2009-09-02 |
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Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101926866B (en) * | 2010-05-12 | 2012-01-04 | 王艳珍 | Anti-hyperosteogeny plaster |
| CN102872284B (en) * | 2012-10-29 | 2014-07-16 | 张红英 | Chinese medicinal composition for treating hyperosteogeny and preparation method thereof |
| CN104415284B (en) * | 2013-08-21 | 2018-06-19 | 魏敬成 | A kind of Chinese medicine composition for treating osteoproliferation and preparation method thereof |
| CN103751749A (en) * | 2014-01-17 | 2014-04-30 | 王钢 | Medicine and preparation for treating joint diseases |
| CN104127618A (en) * | 2014-08-17 | 2014-11-05 | 王勇 | Plaster for treating heumatism |
| CN104161916A (en) * | 2014-08-27 | 2014-11-26 | 江美林 | Traditional Chinese medicine paste and smearing preparation for treating wind-cold-damp scapulohumeral periarthritis as well as nursing method of paste |
| CN104547348A (en) * | 2014-12-26 | 2015-04-29 | 于春华 | Plaster for treating lumbar disc herniation cold-dampness syndrome and preparation method of plaster |
| CN105616792A (en) * | 2016-01-27 | 2016-06-01 | 贵州铜仁梵康生物科技有限责任公司 | Medicine for treating rheumatic bone pain |
| CN109395034A (en) * | 2017-08-18 | 2019-03-01 | 刘永妍 | A kind of plaster that treating osteopathy and preparation method |
| CN108524741A (en) * | 2018-07-13 | 2018-09-14 | 王少林 | A kind of external use plaster for treating osteoarthrosis |
| CN108888516A (en) * | 2018-08-15 | 2018-11-27 | 北京康瑞博生物科技有限公司 | The extraction process of plaster liquid |
| GB2595441B (en) * | 2020-04-23 | 2022-08-10 | Wang Lulin | Bone-Strengthening Pill (BSP) as a Dietary Supplement to Improve Blood Circulation and Strengthen Bone and Muscle |
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2007
- 2007-06-06 CN CNB2007100621257A patent/CN100534487C/en not_active Expired - Fee Related
Non-Patent Citations (2)
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| 中医药治疗类风湿性关节炎进展. 樊冰.山东中医药大学学报，第21卷第（2）期. 1997 |
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