CN105267949A - Medicine prescription for degenerative arthritis and osteoporosis and tablet preparation method thereof - Google Patents
Medicine prescription for degenerative arthritis and osteoporosis and tablet preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the field of medicines, and concretely relates to a medicine prescription for degenerative arthritis and osteoporosis and a tablet preparation method thereof. The medicine prescription for degenerative arthritis and osteoporosis comprises the following compositions: chondroitin sulfate, glucosamine sulfate, calcium carbonate, calcium hydrogenphosphate, vitamin C, vitamin D3 and casein phosphopeptide. The beneficial effects comprise that the prescription is capable of scientifically solving casein phosphopeptides of the old, and is free of side effect in the usage process, is suitable for long-term usage and stable in curative effect. Also, the table preparation method for the prescription possesses the advantages of high production efficiency, low production cost, stable product quality and the like.
Description
Technical field
The invention belongs to field of medicaments, be specifically related to medicament composing prescription and the method for preparing tablet thereof thereof of a kind of degenerative osteoarthritis and osteoporosis.
Background technology
Degenerative osteoarthritis and osteoporosis are the common diseases of old people, closely related with aging, arrive with aging society, this two classes disease has a strong impact on the quality of life of old people, one of fracture most important reason becoming man at an advanced age's death, and osteoporosis not only can affect bone health, bone calcium is to while blood transfer, part calcium ion also can be caused to deposit in blood vessel wall, arteriosclerosis occurs, causes multiple cardiovascular and cerebrovascular disease.
Osteoporosis and degenerative osteoarthritis are the diverse diseases of two classes with regard to pathogeny, therefore, relatively independent to these two kinds of prevention and treatment of diseases for a long time.But these two kinds of diseases are all relevant with aging, there are these two kinds of diseases and have universality in elderly population, and in fact, concerning all old peoples, no matter os osseum generation osteoporosis, or cartilage wear, once after disappearance, all cannot repair, be difficult to reverse.
For degenerative osteoarthritis and osteoporosis, traditional treatment medicine has the following disadvantages: one, curative effect of medication is single, all can not play good curative effect to two kinds of diseases simultaneously; Two, therapeutic purposes are main mainly with improving symptom, fundamentally can not deal with problems from paathogenic factor; Three, the calcium absorptivity of calcium supplementing product is low, chondroitin sulfate and glucosamine content low, ratio is unreasonable, and curative effect is undesirable, easily recurs; Four, the various class drug side effect that relieves the pain is comparatively large, unsuitable life-time service; Etc..The tablet producing technology of existing treatment degenerative osteoarthritis simultaneously and osteoporosis is more complicated, and production cost is higher.
Summary of the invention
In order to solve the problems referred to above that prior art exists, the invention provides a kind of product that can all have good curative effect to degenerative osteoarthritis and osteoporosis two kinds of diseases simultaneously, prevent and treat combination, have no side effect.Meanwhile, method for preparing tablet thereof provided by the invention, object is to obtain that a kind of preparation method is simple, production cost is low, the medicinal tablet of constant product quality.
The medicament composing prescription of degenerative osteoarthritis of the present invention and osteoporosis, comprises following component: chondroitin sulfate, glucosamine sulphate, calcium carbonate, calcium hydrogen phosphate, vitamin C, vitamin D3 and phosphopeptide caseinate.Preferred weight part ratio of each component is: 120 ~ 170 parts of chondroitin sulfate, 200 ~ 250 parts of glucosamine sulphates, 90 ~ 110 parts of calcium carbonate, 90 ~ 110 parts of calcium hydrogen phosphate, 13 ~ 17 parts of vitamin Cs, 0.001 ~ 0.002 part of vitamin D3 and 110 ~ 140 parts of phosphopeptide caseinates.Preferred weight part ratio of further each component is: 150 parts of chondroitin sulfate, 220 parts of glucosamine sulphates, 100 parts of calcium carbonate, 100 parts of calcium hydrogen phosphate, 15 parts of vitamin Cs, 0.00125 part of vitamin D3 and 120 parts of phosphopeptide caseinates.
Meanwhile, present invention also offers the method being prepared medicinal tablet by the medicament composing prescription of aforementioned degenerative osteoarthritis of the present invention and osteoporosis, comprise the steps:
1) get the raw materials ready: take chondroitin sulfate, glucosamine sulphate, calcium carbonate, calcium hydrogen phosphate, vitamin C, vitamin D3 and phosphopeptide caseinate respectively by prescription weight ratio;
2) local mixing: the method taking 1 to 1 to amplify step by step with mixing apparatus, uses calcium carbonate to be diluted by vitamin D3; Described 1 to 1 step by step amplify be specially, first in mixing apparatus, add whole vitamin D3, the calcium carbonate weighed with vitamin D3 etc. is added again in mixing apparatus, obtain the batch mixing one of mix homogeneously, then in mixing apparatus, add the calcium carbonate heavy with batch mixing first-class, mix homogeneously obtains batch mixing two, repeat to continue to add N calcium carbonate, finally obtain whole batch mixing after mix homogeneously, for subsequent use, N is the natural number between 0 ~ 10;
3) always mix: in mixing apparatus, add remaining calcium carbonate, chondroitin sulfate, glucosamine sulphate, calcium hydrogen phosphate, phosphopeptide caseinate and vitamin C, be mixed to get the mixture of uniform composition;
4) granulate: adopt wet granulation that mixture is made granule, and use boiling drying equipment to be 4.5%-6.5% by particle drying to moisture;
5) tabletting: with tablet machine by 4) the dried granule of gained carries out tabletting, obtains tablet;
6) coating: tablet is carried out coating with coating materials, obtains the medicinal tablet preventing and treating degenerative osteoarthritis and osteoporosis.
To the further optimization of method, step 2) in N be 5 or 6 or 7.
The effect of each component of the present invention and compatibility principle each other as follows:
Chondroitin sulfate is a kind of proteoglycan molecule, has hydrophilic, the larger viscosity of height, is attached to tissue surface, all plays an important role, have the ability regulating Growth of Cells, growth and propagation to mass exchange between maintenance connective tissue moisture and tissue.In addition, chondroitin sulfate can remove a large amount of Na absorbed in synovial membrane
+, promote that sclerotin increases, repair impaired joint, increase bone articular cartilage density.Chondroitin sulfate also has the effect suppressing NK cytoactive, ADCC can be prevented the damage of cartilaginous tissue, be conducive to cartilaginous tissue reparation.Chondroitin sulfate concentrates in the cartilage in joint in a large number, can strengthen the absorption of articular cartilage to nutrition, and chondrocyte also can be made to possess enough moisture, thus can reach the effect of buffering and lubrication.The chondroitin sulfate extracted from animal cartilage is the covalently bound class glycosaminoglycans forming Dan Baiduotang proteoglycan PG on protein.Chondroitin sulfate is distributed widely in extracellular matrix and the cell surface of animal tissue, sugar chain is made up of the glucuronic acid replaced and N-acetylgalactosamine (also known as N-acetylamino galactosamine) disaccharide unit, is connected on the serine residue of core protein like sugared link zone by one.
Glucosamine is a kind of derivant of native amino monosaccharide, is the necessary important component of synthetic proteins polysaccharide in cartilage matrix.Dan Baiduotang proteoglycan PG can make articular cartilage have the function absorbing impulsive force by suppressing the tensile force of collagen fiber.Early stage at joint degenerative disease, the biosynthesis assembling dextran increases, in the later stage of disease, then on the contrary.Cause the elasticity of cartilage constantly to weaken thus and engender arthritic many symptoms.Amino monosaccharide can stimulate chondrocyte to produce the glycoprotein with normal multimeric structure, suppress some enzymes that can damage articular cartilage (as collagenase), prevent 17-hydroxy-11-dehydrocorticosterone and some nonsteroidal anti-inflammatory drug to the infringement of chondrocyte, and the release of the endotoxin factor of minimizing damaging cells.In arthritic development process, supplemented with exogenous glucosamine may play useful effect.In vitro in test, if supplement glucosamine, the polyblast forming cartilage just can synthesize more assembles dextran.In arthritic animal model, glucosamine also has antioxidation, suppresses the generation of the superoxide radical of damaging cells.By above-mentioned approach, glucosamine plays direct antiinflammatory action, can the pain symptom of relief from osteoarthritis, improves function of joint, and the osteoarthritis course of disease can be stoped to develop.Oral glucosamine 90% is absorbed, and permeates into blood rapidly by biological barrier, and is distributed to tissue and organ, especially has affinity to articular cartilage, can permeate into articular cartilage matrix, arrives chondrocyte.
Human body Endoskeleton is realized being connected by joint with between skeleton, and the cartilage and the synovial membrane that are distributed in two os osseum tops form articular cavity.In articular cavity, there is synovial fluid, lubricate, greatly reduce the frictional force between two cartilages.Cartilage has cavernous transformation effect, can store synovial fluid, and synovial fluid, when moving stressed, is extruded by joint in cartilage, plays lubrication.Do not have blood capillary and blood supply in cartilage, synovial fluid bears transport task, and one of critical function of chrondroitin is exactly as conveyance conduit, by synovial fluid, oxygen and nutrient is delivered to chondrocyte, and removes the refuse of cartilage inner cell metabolism.Pathological change mainly cartilage wear and the synovial fluid disappearance of degenerative osteoarthritis.
The important component forming cartilage is chrondroitin, glucosamine and collagen protein.The present invention uses chondroitin sulfate and glucosamine sulphate, its objective is nutrition and repairs impaired articular cartilage.Specifically; chondroitin sulfate coordinates with glucosamine; there is pain relieving, promote effect of regenerating bone or cartilage, fundamentally can repair, improve impaired function of joint; chondroitin sulfate has protective effect to cornea collagen fiber; the growth of fiber in substrate can be promoted, strengthen permeability, improve blood circulation; accelerate metabolism, promote the absorption of penetrating fluid and the elimination of inflammation.Researcher adds amino glucosamine sulphate salt carry out clinical trial respectively to chondroitin sulfate, glucosamine sulphate, chondroitin sulfate, take 24 weeks cycles, experimenter's sum 1583 people, be divided into four groups at random, take chondroitin sulfate respectively, glucosamine sulphate, chondroitin sulfate add glucosamine sulphate and placebo, result of the test shows, taking chondroitin sulfate, to add glucosamine sulphate one group of effect improving symptom best.Another test is that 144 degenerative osteoarthritis patients are divided into three groups at random, take placebo, 400mg chondroitin sulfate, 800mg chondroitin sulfate respectively, take 1 year cycle, result, the successful taking 800mg chondroitin sulfate one group is better than other two groups, illustrate and use chondroitin sulfate to there is significant dose-effect relationship, in certain limit, increase dose and can improve curative effect.Through large quantity research, the chondroitin sulfate that the present invention filters out and glucosamine sulphate use total amount and corresponding proportion under, better nutrition can be obtained and repair the effect of damaged articular cartilage.
Calcium carbonate is calsium supplement most widely used at present, and calcium content reaches 40%.Calcium carbonate is high with calcium content, purity is high, production cost is low, is used widely at field of medicaments.Its greatest weakness is that alkalescence is too strong, and initial calcium carbonate is that dissolving 100mg calcium carbonate approximately needs consumption 230 milliliters of gastric acid as treating in gastropathy and the drug use of gastric acid, and the heavy dose of calcium carbonate of long-term taking can cause stomach function damage.Enough gastric acid is the precondition that calcium constituent contained by calcium carbonate is absorbed and used, because intestinal mucosa cells only has ion channel, calcium carbonate molecular volume is comparatively large, can not enter blood through ion channel.The old people lacking gastric juice takes calcium carbonate, and calcium constituent absorption rate is very low, greatly about about 20%.
Calcium hydrogen phosphate is also a kind of calcium source of ideal calcium supplementing product.Compare with calcium carbonate, although calcium content is lower, only have 23.3%, the alkalescence of calcium hydrogen phosphate is more weak, can be slightly soluble in water, generally can not damage gastric mucosa, is more suitable for old people and takes.The more important thing is that the calcium absorptivity of calcium hydrogen phosphate far above calcium carbonate, will can reach more than 36%.Studies have found that, phosphorus plays some facilitation in calcium absorption process, and baby's drink milk calcium absorptivity is high, relevant with the phosphorus in milk.
The present invention combines calcium carbonate and calcium hydrogen phosphate, uses two kinds of calcium sources, its objective is and the advantage in two kinds of calcium sources is obtained maximum performance, and respective weakness drops to minimum.Be aided with phosphopeptide caseinate simultaneously, the absorption of calcium can be promoted further.
Phosphopeptide caseinate is a kind of biologically active polypeptide, has important function for promotion intestinal Calcium-ion absorption.Protection of intestinal mucosal barrier cells only has ion channel, could by protection of intestinal mucosal barrier cells absorbed into serum when calcium constituent only exists with ionic forms, and easy the combination with acid ion of calcium ion forms insoluble molecular state calcium salt and run off in neutral and weakly alkaline environment.The Absorption main manifestations of phosphopeptide caseinate to calcium is, energy and calcium binding under neutrality and weakly alkaline environment, avoids molecular state calcium salt to be formed and calcium constituent loss.After mid small bowel, intestinal pH is gradually in neutral and alkalescence (pH value 7-8), and the effect of phosphopeptide caseinate mainly improves the later calcium absorptivity of mid small bowel.
Vitamin C is also known as ascorbic acid, it is a kind of acid polyol containing 6 carbon atoms, human cell tissue repairs (comprising some redox), the metabolism of phenylalanine, tyrosine, folic acid, ferrum, carbohydrate utilize, fat, protein synthesis, maintain immunologic function, hydroxylation and hydroxytryptamine, keep blood vessel complete, promote nonheme iron absorption etc., all need vitamin C to participate in, vitamin C also has antioxidation, free radical resisting, the multiple effects such as restraint of tyrosinase formation simultaneously.
Use the vitamin C of larger dose in the present invention, main purpose promotes bone collagen synthesis.Human body synthetic bone collagen protein mainly uses two kinds of raw materials, and one is protein, and another kind is vitamin C.Bone collagen is one of main composition forming skeleton and articular cartilage, and osteoporosis and degenerative osteoarthritis two kinds of diseases, all lack relevant with bone collagen.
Vitamin D is cyclopentanoperhy drophenanthrene compounds, can be formed by provitamin D through UV-activated.Vitamin D has extremely important effect for alcium and phosphor metabolization.Vitamin D maintains Serum Calcium Phosphorus concentration stabilize, and when blood calcium concentration is low, the secretion of vitamin D induction parathyroid hormone, is released into kidney and osteocyte.In kidney, parathyroid hormone is except stimulation 1 carboxylase and suppression 24 carboxylated enzymes, and also impel phosphorus to discharge from urine, calcium is heavily absorbed in renal tubules.Parathyroid hormone and 1 in bone, 25 dihydroxy vitamin d3 synergism, mobilize out from bone by calcium.In small intestinal, 1,25 dihydroxy vitamin d3s promote the absorption of calcium.Vitamin D makes blood calcium return to normal level by these three kinds of approach, again the secretion and 1 of feedback control parathyroid hormone, the synthesis of 25 dihydroxy vitamin d3s.Stimulate parafollicular cells of thyroid gland when blood calcium height, produce calcitonin, stop calcium to mobilize out from bone, and impel calcium and phosphorus to discharge from urine.Intestinal absorption phosphorus is active absorption, needs energy, sodium, glucose, 1, when 25 dihydroxy vitamin d3s and serum paraoxonase reduce, stimulates the synthesis of 1,25 dihydroxy vitamin d3s, promotes that small intestinal is to the absorption of calcium, phosphorus.Because parathyroid hormone does not participate in reaction, so calcium is discharged from urine and phosphorus is not discharged, thus make blood calcium slightly increase, and phosphorus rises more, make serium inorganic phosphorus return to normal value.
Solar ulatraviolet radiation is the essential condition of human body synthesis of vitamin d, and old people lacks outdoor activities, and physiological function decline, and the vitamin D causing self to synthesize reduces, and is that osteoporotic major reason occurs old people.Therefore, in the present invention, appropriateness uses vitamin D3.
Based on above discussion, beneficial effect of the present invention: the medicament composing prescription of degenerative osteoarthritis provided by the invention and osteoporosis science can solve two kinds of diseases of old people simultaneously, and use procedure is free from side effects, stable curative effect, not easily recurs.Meanwhile, the control degenerative osteoarthritis obtained by preparation method of the present invention and the tablet of osteoporosis also possess that production technology is simple, constant product quality, the advantages such as production cost is low.
Detailed description of the invention
Below in conjunction with specific embodiment and effect example, the present invention is further explained.
Embodiment 1:
The degenerative osteoarthritis of the present embodiment 1 and the medicament composing prescription of osteoporosis comprise following component: the phosphopeptide caseinate of the calcium carbonate of the chondroitin sulfate of 120g, the glucosamine sulphate of 200g, 90g, the calcium hydrogen phosphate of 90g, the vitamin C of 13g, the vitamin D3 of 1mg and 110g.
The present embodiment 1 additionally provides the medicinal tablet of control degenerative osteoarthritis and the osteoporosis prepared by the medicament composing prescription of the present embodiment 1, and concrete preparation method is as follows: get the raw materials ready by recipe requirements.1 to 1 method of amplifying step by step is adopted in mixing apparatus, calcium carbonate is used to be diluted by vitamin D3: namely first in mixing apparatus, to add whole vitamin D3, the calcium carbonate weighed with vitamin D3 etc. is added again in mixing apparatus, mix homogeneously obtains batch mixing one, the calcium carbonate heavy with batch mixing first-class is added again in mixing apparatus, mix homogeneously obtains batch mixing two, repeats to continue to add 5 calcium carbonate, finally obtain whole batch mixing after mix homogeneously by this rule.In mixing apparatus, add remaining calcium carbonate, chondroitin sulfate, glucosamine sulphate, calcium hydrogen phosphate, phosphopeptide caseinate and vitamin C, be mixed to get the mixture of uniform composition.Adopt wet granulation that mixture is made granule, and use boiling drying equipment to be 4.5% by particle drying to moisture.With tablet machine, dried granule is carried out tabletting, obtain tablet.With coating materials, tablet is carried out coating, obtain the medicinal tablet preventing and treating degenerative osteoarthritis and osteoporosis.
Embodiment 2
The degenerative osteoarthritis of the present embodiment 2 and the medicament composing prescription of osteoporosis comprise following component: the phosphopeptide caseinate of the calcium carbonate of the chondroitin sulfate of 150g, the glucosamine sulphate of 220g, 100g, the calcium hydrogen phosphate of 100g, the vitamin C of 15g, the vitamin D3 of 1.25mg and 120g.
The present embodiment 2 additionally provides the medicinal tablet of control degenerative osteoarthritis and the osteoporosis prepared by the medicament composing prescription of the present embodiment 2, and concrete preparation method is as follows: get the raw materials ready by recipe requirements.1 to 1 method of amplifying step by step is adopted in mixing apparatus, calcium carbonate is used to be diluted by vitamin D3: namely first in mixing apparatus, to add whole vitamin D3, the calcium carbonate weighed with vitamin D3 etc. is added again in mixing apparatus, mix homogeneously obtains batch mixing one, the calcium carbonate heavy with batch mixing first-class is added again in mixing apparatus, mix homogeneously obtains batch mixing two, repeats to continue to add 6 calcium carbonate, finally obtain whole batch mixing after mix homogeneously by this rule.In mixing apparatus, add remaining calcium carbonate, chondroitin sulfate, glucosamine sulphate, calcium hydrogen phosphate, phosphopeptide caseinate and vitamin C, be mixed to get the mixture of uniform composition.Adopt wet granulation that mixture is made granule, and use boiling drying equipment to be 6% by particle drying to moisture.With tablet machine, dried granule is carried out tabletting, obtain tablet.With coating materials, tablet is carried out coating, obtain the medicinal tablet preventing and treating degenerative osteoarthritis and osteoporosis.
Embodiment 3
The degenerative osteoarthritis of the present embodiment 3 and the medicament composing prescription of osteoporosis comprise following component: the phosphopeptide caseinate of the calcium carbonate of the chondroitin sulfate of 170g, the glucosamine sulphate of 250g, 110g, the calcium hydrogen phosphate of 110g, the vitamin C of 17g, the vitamin D3 of 2mg and 140g.
The present embodiment 3 additionally provides the medicinal tablet of control degenerative osteoarthritis and the osteoporosis prepared by the medicament composing prescription of the present embodiment 3, and concrete preparation method is as follows: get the raw materials ready by recipe requirements.1 to 1 method of amplifying step by step is adopted in mixing apparatus, calcium carbonate is used to be diluted by vitamin D3: namely first in mixing apparatus, to add whole vitamin D3, the calcium carbonate weighed with vitamin D3 etc. is added again in mixing apparatus, mix homogeneously obtains batch mixing one, the calcium carbonate heavy with batch mixing first-class is added again in mixing apparatus, mix homogeneously obtains batch mixing two, repeats to continue to add 7 calcium carbonate, finally obtain whole batch mixing after mix homogeneously by this rule.In mixing apparatus, add remaining calcium carbonate, chondroitin sulfate, glucosamine sulphate, calcium hydrogen phosphate, phosphopeptide caseinate and vitamin C, be mixed to get the mixture of uniform composition.Adopt wet granulation that mixture is made granule, and use boiling drying equipment to be 6.5% by particle drying to moisture.With tablet machine, dried granule is carried out tabletting, obtain tablet.With coating materials, tablet is carried out coating, obtain the medicinal tablet preventing and treating degenerative osteoarthritis and osteoporosis.
Embodiment 4:
The degenerative osteoarthritis of the present embodiment 4 and the medicament composing prescription of osteoporosis comprise following component: the phosphopeptide caseinate of the vitamin C of the calcium carbonate of the chondroitin sulfate of 120g, the glucosamine sulphate of 200g, 110g, the calcium hydrogen phosphate of 90g, 17g, 1mg vitamin D3 and 125g.
The present embodiment 4 additionally provides the medicinal tablet of control degenerative osteoarthritis and the osteoporosis prepared by the medicament composing prescription of the present embodiment 4, and concrete preparation method is as follows: get the raw materials ready by recipe requirements.1 to 1 method of amplifying step by step is adopted in mixing apparatus, calcium carbonate is used to be diluted by vitamin D3: namely first in mixing apparatus, to add whole vitamin D3, the calcium carbonate weighed with vitamin D3 etc. is added again in mixing apparatus, mix homogeneously obtains batch mixing one, the calcium carbonate heavy with batch mixing first-class is added again in mixing apparatus, mix homogeneously obtains batch mixing two, repeats to continue to add 8 calcium carbonate, finally obtain whole batch mixing after mix homogeneously by this rule.In mixing apparatus, add remaining calcium carbonate, chondroitin sulfate, glucosamine sulphate, calcium hydrogen phosphate, phosphopeptide caseinate and vitamin C, be mixed to get the mixture of uniform composition.Adopt wet granulation that mixture is made granule, and use boiling drying equipment to be 5.5% by particle drying to moisture.With tablet machine, dried granule is carried out tabletting, obtain tablet.With coating materials, tablet is carried out coating, obtain the medicinal tablet preventing and treating degenerative osteoarthritis and osteoporosis.
Medicinal tablet below for using embodiments of the invention to obtain carries out effective percentage statistical data and the model case of degenerative osteoarthritis and osteoporosis treatment.In following test example, the mode of taking of medicinal tablet is oral, and taking dose is a twice-daily, each 2, every sheet 1g
Test example 1:
This test example provides the effective percentage statistical data to degenerative osteoarthritis of medicinal tablet of the present invention (obvious effective rate, effective percentage, inefficiency) and concrete typical treatment case.
Effective: degenerative osteoarthritis symptom significantly takes a turn for the better or disease disappears;
Effective: degenerative osteoarthritis symptom takes a turn for the better to some extent;
Invalid: degenerative osteoarthritis symptom is unchanged or aggravate.
Concrete statistical data is as shown in the table: (the effective related data in table also contains effective data simultaneously)
| Test number | Effective number | Obvious effective rate | Efficiently individual quantity | Effective percentage | Invalid number | Inefficiency |
| 45 | 39 | 86.7％ | 42 | 93.3％ | 3 | 6.67％ |
Typical case:
Example 1: Mrs Wang, 56 years old, government functionary, height 1 meter 58, body weight 70 kilograms, was diagnosed as two knee joint degenerative osteoarthritis, X-ray examination display articular cartilage serious wear, sour, numb, swollen, the multiple symptom of pain, difficulty in walking.Took multi-medicament, long-term taking D-glucosamine, effect is all undesirable, and joint replacement surgery is carried out in former preparation.Take the medicinal tablet 7 days of the embodiment of the present invention 2, multiple symptom obviously alleviates.Take 8 weeks continuously, various transference cure, walking freely.Take examination in hospital after 16 weeks to find, function of joint is obviously repaired, and doctor advised wouldn't need to carry out joint replacement.
Example 2: Mr. Li, 69 years old, basketball was trained.Long campaigns sports, five teens are just diagnosed as degenerative osteoarthritis, and knee is red and swollen, and distending pain, dysstasia, once carried out multi-medicament and naturopathy, effect is bad.Take the medicinal tablet 5 days of the embodiment of the present invention 2, pain symptom alleviates; After taking 2 weeks, the phenomenon of knee redness disappears, and patient feels inconceivable.Once long-term taking D-glucosamine and chrondroitin sheet, but also take some Chinese medicine series products, all without this positive effect simultaneously.After taking three wheat harvesting periods, function of joint is obviously recovered, and freely, stair activity joint is strong, accessible in activity.
Example 3: Mrs Tong, 82 years old, peasant, long campaigns rural labor, suffer from serious osteoporosis and degenerative osteoarthritis, finger, toe joint gross distortion, stiff, lower limb is soft, walking needs with the hands to support by quadropods, slow in one's movements, needs others to help when sitting posture stands up.After taking medicinal tablet 3 wheat harvesting period of the embodiment of the present invention 2, the transference cure of arthralgia, swelling, ankylosis is eased, bending finger can stretch, and sensation lower limb is not soft, and both legs are strong, can stand firm, when standing up, not need others to assist in, quadropods oneself can not be used to walk.
Test example 2:
This test example provide medicinal tablet of the present invention to osteoporotic effective percentage statistical data (obvious effective rate, effective percentage, inefficiency) and concrete typical treatment case.
Effective: osteoporosis symptoms significantly takes a turn for the better or disease disappears;
Effective: osteoporosis symptoms takes a turn for the better to some extent;
Invalid: osteoporosis symptoms is unchanged or aggravate.
Concrete statistical data is as shown in the table: (the effective related data in table also contains effective data simultaneously)
| Test number | Effective number | Obvious effective rate | Efficiently individual quantity | Effective percentage | Invalid number | Inefficiency |
| 45 | 36 | 80.0％ | 39 | 86.7％ | 6 | 13.3％ |
Typical case:
Example 1: Mrs Zhao, 74 years old, building designers.Before two more than ten years, whole body skeleton pain, both hands are unable, and lower limb is soft, are diagnosed as severe osteoporosis through Bone mineral density, and after taking calcium-enriching products, symptom is eased.Increase with the age, effect of supplemented calcium declines.Height becomes 1.55 meters from 1.59 meters, and the symptoms such as the soreness of waist, backache, cramp in the leg are serious all the more.Once because of cold cough when 65 years old, cause two fractures of rib.In November, 2014, fall down because of carelessness when balcony cleaning, right finesse joint, right forearm and right thigh three place fracture, Post operation was hospital six weeks, doctor judges that patient's post-operative recovery is very bad, and suggestion goes home to recuperate, and reminds family members, if long-term bed, patient is the disease such as concurrent cardiopulmonary exhaustion most probably.After leaving hospital, patient changes and takes medicinal tablet of the present invention, and the wound site of fracture is recovered rapidly, the multiple symptom of osteoporosis also be improved significantly, after taking this product one wheat harvesting period, patient's right hand function is recovered substantially, can lift the object of lighter in weight, right lower limb also feels strong, can get up lowerly, lower walking is assisted at others, after taking medicinal tablet two wheat harvesting period of the present invention, the right lower limb of patient recovers normal substantially, does not re-use crutch, take care of oneself, do not need others to look after.
Example 2: Mr. Zhang, 78 years old, retired cadre.Winter in 2014 falls down on the ground frozen by bike, because speed is fast, and left forearm and left side fracture of thigh.After operation surrounding, the healing of two places is all undesirable, and especially thigh recovering physiotherapy effect is poor, the bending difficulty of left lower limb, and back constant pain, Leg Cramps, and doctor thinks that patient's osteoporosis is comparatively serious, may need long-term bed.The 5 weeks rear patients that perform the operation leave hospital and go home to recuperate.Take medicinal tablet of the present invention after two weeks, the transference cure of entire patient's skeleton pain and leg cramp, thigh recovering physiotherapy training effect obviously improve, left lower limb heavy burden ability improves, can walk by ground contact type by crutch left foot, after one month, patient can abandon crutch walking.Check Shi doctor thinks, as the man at an advanced age of severe osteoporosis, Mr. Zhang's rehabilitation efficacy surpasss the expectation completely, is that this prescription product has played important function.
The present invention is not limited to above-mentioned preferred forms; anyone can draw other various forms of products under enlightenment of the present invention; though but do any change in detail at it, every have identical with the application or akin technical scheme, all drops within protection scope of the present invention.
Claims (5)
1. a medicament composing prescription for degenerative osteoarthritis and osteoporosis, is characterized in that, comprises following component: chondroitin sulfate, glucosamine sulphate, calcium carbonate, calcium hydrogen phosphate, vitamin C, vitamin D3, phosphopeptide caseinate.
2. the medicament composing prescription of degenerative osteoarthritis according to claim 1 and osteoporosis, it is characterized in that, comprise following parts by weight of component: 120 ~ 170 parts of chondroitin sulfate, 200 ~ 250 parts of glucosamine sulphates, 90 ~ 110 parts of calcium carbonate, 90 ~ 110 parts of calcium hydrogen phosphate, 13 ~ 17 parts of vitamin Cs, 0.001 ~ 0.002 part of vitamin D3 and 110 ~ 140 parts of phosphopeptide caseinates.
3. the medicament composing prescription of degenerative osteoarthritis according to claim 2 and osteoporosis, it is characterized in that, comprise following parts by weight of component: 150 parts of chondroitin sulfate, 220 parts of glucosamine sulphates, 100 parts of calcium carbonate, 100 parts of calcium hydrogen phosphate, 15 parts of vitamin Cs, 0.00125 part of vitamin D3 and 120 parts of phosphopeptide caseinates.
4. prepared a method for medicinal tablet by the medicament composing prescription of the arbitrary described degenerative osteoarthritis of claims 1 to 3 and osteoporosis, it is characterized in that, comprise the steps:
1) get the raw materials ready: take chondroitin sulfate, glucosamine sulphate, calcium carbonate, calcium hydrogen phosphate, vitamin C, vitamin D3 and phosphopeptide caseinate respectively by prescription weight ratio;
2) local mixing: the method taking 1 to 1 to amplify step by step with mixing apparatus, uses calcium carbonate to be diluted by vitamin D3; Described 1 to 1 amplifies step by step and is specially: first in mixing apparatus, add whole vitamin D3, the calcium carbonate weighed with vitamin D3 etc. is added again in mixing apparatus, obtain the batch mixing one of mix homogeneously, the calcium carbonate heavy with batch mixing first-class is added again in mixing apparatus, mix homogeneously obtains batch mixing two, repeats to continue to add N calcium carbonate, finally obtains whole batch mixing after mix homogeneously, for subsequent use, N is the natural number between 0 ~ 10;
3) always mix: in mixing apparatus, add remaining calcium carbonate, chondroitin sulfate, glucosamine sulphate, calcium hydrogen phosphate, phosphopeptide caseinate and vitamin C, be mixed to get the mixture of uniform composition;
4) granulate: adopt wet granulation that mixture is made granule, and use boiling drying equipment to be 4.5%-6.5% by particle drying to moisture;
5) tabletting: with tablet machine by 4) the dried granule of gained carries out tabletting, obtains tablet;
6) coating: tablet is carried out coating with coating materials, obtains the medicinal tablet preventing and treating degenerative osteoarthritis and osteoporosis.
5. method according to claim 4, is characterized in that: N is 5 or 6 or 7.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2019011298A (en) * | 2017-06-30 | 2019-01-24 | 小林製薬株式会社 | Oral composition with glucosamine coated with calcium compound |
| CN111773378A (en) * | 2020-08-11 | 2020-10-16 | 聊城市人民医院 | Mesenchymal stem cell compound injection for osteoarthritis |
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| JP2019011298A (en) * | 2017-06-30 | 2019-01-24 | 小林製薬株式会社 | Oral composition with glucosamine coated with calcium compound |
| JP7334025B2 (en) | 2017-06-30 | 2023-08-28 | 小林製薬株式会社 | Oral composition in which glucosamine is coated with a calcium compound |
| CN111773378A (en) * | 2020-08-11 | 2020-10-16 | 聊城市人民医院 | Mesenchymal stem cell compound injection for osteoarthritis |
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