JP2019011298A - Oral composition with glucosamine coated with calcium compound - Google Patents

Abstract

To provide an oral composition (tablet) that has a high compounding ratio of an active ingredient, has sufficient hardness, and shows excellent collapsibility.SOLUTION: An oral composition contains glucosamine or salt thereof, the surface of which is wholly or partially coated with a calcium compound.SELECTED DRAWING: None

Description

  The present invention relates to an oral composition in which glucosamine is coated with a calcium compound.

  Glucosamine is a kind of amino sugar and is a component contained in various tissues such as animal skin, bone, and cartilage. In recent years, the therapeutic effect of glucosamine hydrochloride on knee joint pain has been reported (Non-patent Document 1).

  Calcium is a component of bone and a nutrient necessary for bone formation. With aging, the bone density decreases simultaneously with the decrease in knee joint function. Therefore, it is necessary to care for joints and bones to prevent the elderly from falling.

  That is, providing an oral composition that can simultaneously take glucosamine and calcium is important for maintaining the health of the elderly. There is this demand, and tablets containing glucosamine and calcium are currently marketed as health foods.

  When producing tablets for health foods, in general, in addition to the active ingredient, a tablet such as crystalline cellulose, a fluidizing agent such as finely divided silicon dioxide, a lubricant such as sucrose fatty acid ester, etc. is mixed and compressed. . And the tablet which has the target hardness and disintegration time is produced by adjusting the ratios, such as an excipient | filler.

  On the other hand, since it is difficult to drink if the size of the tablet is large, it is generally desirable to adjust the size to such an extent that it is not difficult to visually recognize and handle, the size is small, and the number of tablets to be taken is small. Therefore, reducing the blending ratio of excipients other than active ingredients leads to tablets that are easy to take. However, if the mixing ratio of excipients other than the active ingredient is reduced in the tablet, there arises a problem that the intended hardness and disintegration time cannot be obtained.

  Therefore, techniques for obtaining the desired hardness and disintegration time while reducing the blending ratio of excipients have been disclosed for the purpose of increasing the blending ratio of active ingredients. Patent Document 1 discloses a rapidly disintegrating compression molded product containing an excipient and erythritol. Patent Document 2 discloses a composition for an orally rapidly disintegrating tablet containing a saccharide such as mannitol, an inorganic excipient, and a disintegrant. However, since the prior art is a technique for reducing the ratio of crystalline cellulose by adding an excipient, the blending ratio of the active ingredient is lowered by the amount of addition of the excipient.

Journal of Japanese Society of Clinical Nutrition 1998, 20, pg.41-47

JP2003-176242 Republished patent WO2005 / 037254

  An object of the present invention is to provide an oral composition (tablet) having a high blending ratio of active ingredients, sufficient hardness, and excellent disintegration.

  The present inventors coated glucosamine with a calcium compound, and when a tablet containing a composition containing the same is produced to produce a tablet, the tablet is difficult to chip, has sufficient hardness, and has an excellent disintegration property. It has been found that a composition (tablet) can be prepared.

Oral Composition Item 1.
An oral composition in which part or all of the surface of glucosamine or a salt thereof is coated with a calcium compound.

Item 2.
Item 2. The oral composition according to Item 1, wherein the calcium compound is calcium carbonate.

Item 3.
Item 3. The oral composition according to Item 1 or 2, wherein the calcium compound is a powder.

Item 4.
Item 4. The oral composition according to any one of Items 1 to 3, which is in the form of granules or tablets.

Granulated matter 5.
A granulated product in which part or all of the surface of glucosamine or a salt thereof is coated with a calcium compound.

Item 6.
Item 6. The granulated product according to Item 5, wherein the calcium compound is calcium carbonate.

Item 7.
Item 7. The granulated product according to Item 5 or 6, wherein the calcium compound is a powder product.

Item 8. Manufacturing method of granulated material
A method for producing a granulated product containing glucosamine or a salt thereof and a calcium compound,
A method for producing a granulated product comprising a step of granulating by mixing glucosamine or a salt thereof and a calcium compound.

Item 9.
Item 9. The method for producing a granulated product according to Item 8, wherein the calcium compound is calcium carbonate.

Item 10.
Item 10. The method for producing a granulated product according to Item 8 or 9, wherein the calcium compound is a powder product.

10. Manufacturing method of tablets
A method for producing a tablet containing glucosamine or a salt thereof and a calcium compound,
A tablet production method comprising a step of granulating by mixing glucosamine or a salt thereof and calcium powder, and a step of tableting the granulated product obtained in the step.

Item 12.
Item 12. The method for producing a tablet according to Item 11, wherein the calcium compound is calcium carbonate.

Item 13.
Item 13. The method for producing a tablet according to Item 11 or 12, wherein the calcium compound is a powder.

Preferred range of blending ratio In the oral composition and granulated product, the content of glucosamine or a salt thereof is preferably 10 to 80% by weight.

  In the oral composition and granulated product, the calcium compound content is preferably 0.1 to 64% by weight.

  However, in the present invention, regarding the content of the glucosamine or a salt thereof and the content of the calcium compound, the total content in the oral composition does not exceed 100% by weight.

  In the oral composition and granulated product, the blending ratio (weight ratio) of glucosamine or a salt thereof and a calcium compound is in the range of 1 to 80 parts by weight of the calcium compound with respect to 100 parts by weight of glucosamine or a salt thereof. preferable.

  In the present invention, the phrase “a part or all of the surface of glucosamine or a salt thereof is coated with a calcium compound” means that a part of the surface of glucosamine or a salt thereof is a calcium compound as long as the effect of the present invention is achieved. To a mode in which the entire surface of glucosamine or a salt thereof (approximately 100% surface coverage or 100% surface coverage) is coated with a calcium compound.

  In the coated granulated product, the coverage of the calcium compound is not particularly limited.

  The coverage when the coating with the calcium compound is “partial” is, for example, about 20% or more, preferably 30% or more, more preferably 40% or more, still more preferably 50% or more, and particularly preferably 65%. Above, most preferably 80% or more.

  Here, the “coverage of calcium compound” was obtained by observing the granulated product with a scanning electron microscope, obtaining the coverage of each granulated product according to the following formula, and obtaining with 10 or more granulated products. It is a value obtained by calculating the average value of the coverage.

  Such a coverage can be adjusted by appropriately setting the amount of glucosamine or a salt thereof used as a raw material, the amount of a calcium compound, conditions for fluidized bed granulation, and the like.

[Equation 1]
Coverage (%) = {(surface area of the granulated product−area of the area where glucosamine or a salt thereof is exposed in the granulated product) / surface area of the granulated product} × 100

  According to the present invention, a tablet having a high blending ratio of glucosamine or a salt thereof, sufficient hardness, and excellent disintegration can be provided.

  According to the present invention, tableting properties in producing tablets are improved by coating glucosamine or a salt thereof with a calcium compound.

It is a scanning electron micrograph (350 times) of (1) glucosamine hydrochloride, (2) calcium carbonate (scallop powder) and (3) granulated product (glucosamine hydrochloride: calcium carbonate = 100: 20). It is a figure showing the hardness and disintegration time of a tablet. It is a figure showing the relative ratio of the hardness of the tablet with and without granulation in the difference in the content of calcium carbonate.

(1) Oral composition The oral composition of the present invention comprises glucosamine or a salt thereof and a calcium compound, wherein a part or all of the surface of the glucosamine or a salt thereof is coated with the calcium compound. .

  By using the oral composition of the present invention, a tablet having a high blending ratio of glucosamine or a salt thereof, sufficient hardness, and excellent disintegrability can be produced.

Glucosamine or a salt thereof In the oral composition of the present invention, part or all of the surface of glucosamine or a salt thereof is coated with a calcium compound.

  Glucosamine is 2-aminoglucose (molecular weight 180) in which the hydroxyl group at the 2-position of glucose is substituted with an amino group, and is widely distributed in important biological components such as glycoproteins, glycolipids, and mucopolysaccharides. It is a typical natural amino sugar. Glucosamine is contained in various tissues such as animal skin, bone, cartilage, and shells of crustaceans such as shrimps and crabs.

  Glucosamine used in the present invention is not particularly limited by its origin or production method. For example, the glucosamine targeted by the present invention includes fermented glucosamine produced by fermentation using a plant as a raw material. The glucosamine targeted by the present invention also includes N-acetylglucosamine.

  The glucosamine salt is not particularly limited as long as it is a pharmaceutically acceptable salt. For example, a salt with an inorganic acid such as hydrochloric acid, sulfuric acid, nitric acid or phosphoric acid; a salt with an organic acid such as citric acid, succinic acid, acetic acid, tartaric acid or lactic acid is preferable. Preferred are glucosamine inorganic acid salts such as glucosamine hydrochloride and glucosamine sulfate.

  Glucosamine or a salt thereof is known to have a joint pain relieving effect, a blood flow promoting effect, and a skin beautifying effect. For this reason, glucosamine or a salt thereof is useful as an active ingredient of a supplement (food product), a quasi-drug, or a pharmaceutical product having the above function.

Calcium Compound In the oral composition of the present invention, the calcium compound coats part or all of the surface of glucosamine or a salt thereof.

  The calcium compound is calcium carbonate (including shell uncalcined calcium, coral uncalcined calcium, nacreous uncalcined calcium, eggshell uncalcined calcium, sea urchin calcined calcium, shell calcined calcium, reef-building coral calcined calcium, eggshell calcined calcium) , Calcium phosphate (including bone uncalcined calcium, bone calcined calcium, whey calcined calcium), calcium gluconate, calcium lactate, calcium citrate, calcium stearate, calcium sulfate, calcium glycerophosphate, calcium chloride, calcium oxide, calcium hydroxide, Preferably, it is at least one selected from the group consisting of calcium dihydrogen pyrophosphate (calcium pyrophosphate), calcium acetate, calcium citrate, and calcium stearoyl lactate.

The average particle size calcium compound of the calcium compound is not limited in shape, and may be powdery, pulverized, or granular.

  The calcium compound is preferably a powder.

  The size (particle size) of the calcium compound is not particularly limited. The average particle size of the calcium compound is preferably 0.1 to 500 μm, more preferably 0.3 to 100 μm, and still more preferably 0.5 to 50 μm.

  Here, the average particle diameter means the particle diameter at an integrated value of 50% in the particle size distribution obtained by the laser diffraction / scattering method. The laser diffraction / scattering method is a method for measuring the particle size by utilizing the difference in the light intensity distribution of the diffracted and scattered light depending on the particle size when laser light is applied to the particle. The particle size distribution measuring device (for example, “Laser particle size analyzer SALD-2200” manufactured by Shimadzu Corporation) can be used.

Preferred range of blending ratio In an oral composition, it is preferable to adjust the content and blending ratio of glucosamine or a salt thereof and a calcium compound as appropriate to prepare a tablet having sufficient hardness and exhibiting excellent disintegration.

  In the oral composition and granulated product, the content of glucosamine or a salt thereof is preferably 10 to 80% by weight, more preferably 20 to 70% by weight, and further preferably 30 to 70% by weight. .

  In the oral composition and granulated product, the content of the calcium compound is preferably 0.1 to 64% by weight, more preferably 0.2 to 56% by weight, and still more preferably 0.3 to 56% by weight.

  However, in the present invention, regarding the content of the glucosamine or a salt thereof and the content of the calcium compound, the total content in the oral composition does not exceed 100% by weight.

  In the oral composition and granulated product, the blending ratio (weight ratio) of glucosamine or a salt thereof and a calcium compound is preferably 1 to 80 parts by weight of the calcium compound with respect to 100 parts by weight of glucosamine or a salt thereof. It is more preferably 5 to 60 parts by weight, further preferably 10 to 40 parts by weight, particularly preferably 15 to 30 parts by weight, and most preferably 15 to 25 parts by weight.

  In the present invention, from the aspect in which a part of the surface of glucosamine or a salt thereof is coated with a calcium compound as long as the effects of the present invention are achieved, the entire surface of glucosamine or a salt thereof (almost 100% surface coverage or 100%). % Surface coverage) is included up to the aspect where it is coated with a calcium compound.

Tableting property improving agent The oral composition of the present invention is useful as a tableting property improving agent for tablets containing glucosamine or a salt thereof and a calcium compound.

Method for improving tabletability The oral composition of the present invention comprises a glucosamine or a salt thereof and a tablet containing the calcium compound by coating a part or all of the surface of the glucosamine or a salt thereof with the calcium compound. A tablet having a high salt blending ratio, sufficient hardness, and excellent disintegration can be produced.

  The tableting improver of the present invention is used in a tablet containing glucosamine or a salt thereof and a calcium compound, wherein a part or all of the surface of the glucosamine or a salt thereof is coated with the calcium compound. It was discovered by discovering an unknown attribute that can improve the performance.

(2) Granulated product The present invention is also a granulated product containing glucosamine or a salt thereof and a calcium compound, wherein a part or all of the surface of the glucosamine or a salt thereof is coated with the calcium compound. This is a granulated product.

  The aspect of the said oral composition can be employ | adopted for content of each component contained in a granulated material, and each component.

The size (particle size) of the average particle size of the granulated product is not particularly limited.

  The average particle size of the granulated product is preferably 1 to 2,000 μm, more preferably 5 to 1,500 μm, and still more preferably 10 to 1,000 μm.

  Here, the average particle diameter means the particle diameter at an integrated value of 50% in the particle size distribution obtained by the laser diffraction / scattering method as described above.

The granulated product containing the glucosamine of the present invention or a salt thereof and a calcium compound,
It can be manufactured by a method including a step of granulating by mixing glucosamine or a salt thereof and a calcium compound.

  Granulation is usually performed using a conventional granulator. Examples of the granulator include a fluidized bed granulator, a stirring granulator, and an extrusion granulator.

  For granulation, for example, the glucosamine or a salt thereof and calcium powder are mixed in a granulation tank of the granulator. The mixture can be carried out while uniformly spraying a binder such as an aqueous solution containing water, ethanol, and reduced maltose.

  Conditions at the time of granulation such as the supply temperature in the granulation tank and the temperature of the spray liquid can be appropriately set. Usually, the supply air temperature is preferably 40 to 90 ° C. The temperature of the spray liquid is preferably 10 to 40 ° C.

  The granulated product (granules) is dried as necessary to remove contained water. The drying temperature is preferably 20 to 90 ° C.

  The dried granulated product (granules) can be appropriately sized as necessary.

  Next, the granulated product (granules) is tableted and formed into a tablet shape.

  By employing the method for producing a granulated product of the present invention, a granulated product in which part or all of the surface of glucosamine or a salt thereof is coated with a calcium compound can be produced. By producing a tablet using the obtained granulated product, a tablet having a high blending ratio of glucosamine or a salt thereof, sufficient hardness, and excellent disintegration can be produced.

(3) Form of oral composition The oral composition of the present invention contains glucosamine or a salt thereof and a calcium compound, and as long as the quality of the product can be maintained based on the effects of the present invention. There is no particular limitation on the form, use mode, and application.

  The oral composition of the present invention preferably has the form of granules or tablets. Examples of usage forms of the oral composition of the present invention include food compositions (various health functional foods, etc.), pharmaceutical compositions, etc., oral pharmaceutical compositions (including quasi drugs), food compositions (food additives) Are preferred).

  The oral pharmaceutical composition may be used as it is, or may be prepared in various dosage forms together with carriers and additives that are acceptable in the pharmaceutical field.

  The dosage form of the oral pharmaceutical composition is preferably a solid preparation such as powder, tablet, granule, pill, chewable tablet, and dry syrup. Moreover, you may have a formulation form which controlled the release | release property of the medicinal component (for example, immediate release formulation, sustained release formulation, etc.). Formulations having such dosage forms can be prepared according to conventional methods in the art.

  The dose (ingestion amount) of the oral pharmaceutical composition is not particularly limited, and is determined by the use of the preparation, the age, sex, degree of symptoms to be treated, administration method and the like of the patient.

  Food compositions are prepared as functional foods such as various health functional foods (nutrient functional foods, foods for specified health use, supplements, etc.) and foods for the sick based on the physiological action of glucosamine or a salt thereof and a calcium compound. be able to.

  When prepared as a food, it can be prepared in the form of granules, powders, tablets (including chewables, etc.), pills, etc. so as to facilitate continuous ingestion. As the food composition, a tablet form is preferable from the viewpoint of easy intake.

  The food composition can be appropriately prepared according to a conventional method using a carrier acceptable in the field of food.

  Further, as long as the effect of the present invention is not suppressed, excipients, stabilizers, dispersants, fluidizing agents, buffering agents, wetting agents, thickening agents, preservatives, pH, acceptable as normal additives Arbitrary components, such as a regulator, a solvent, and a solubilizing agent, can be added as desired.

Content ratio of glucosamine or a salt thereof and calcium compound The content ratio of glucosamine or a salt thereof and calcium compound in the tablet is not particularly limited. When glucosamine or a salt thereof and a calcium compound are the active ingredients of the tablet, the total content is preferably 50% by weight or more, more preferably 60% by weight or more.

(4) Manufacturing method of tablet The tablet containing the glucosamine of the present invention or a salt thereof and a calcium compound,
It can be produced by a method comprising a step of granulating by mixing glucosamine or a salt thereof and calcium powder, and a step of tableting the granulated product obtained in the step.

  The tablet of this invention can be manufactured in accordance with the conventional method of this industry.

  For granulation, the above-mentioned method for producing a granulated product can be adopted.

  Next, the granulated product (granules) is tableted and formed into a tablet shape.

  Tableting is performed by filling a granulated product into a cylindrical mortar, grinding the filled granulated product into a fixed amount with a grinding plate, and compressing it with upper and lower scissors. As the tableting machine, a known device such as a high-speed rotary tableting machine can be used.

  The operating conditions such as tableting pressure vary depending on the shape and size of the tablet to be produced. For example, the granulated product is tableted using a tableting machine equipped with a punch having a diameter of 5 to 20 mm and a curvature radius of 6 to 24 mm. For example, when producing a 200 mg round tablet, it is preferable to perform tableting under a tableting pressure of about 10 kN.

Embodiment of tablet The tablet produced in this way has a tablet hardness of 40 N or more, and has sufficient hardness as a tablet. The hardness of a tablet is determined by measuring the hardness of a plurality of tablets using a load cell type hardness tester and obtaining an average value thereof.

  If the tablet hardness is within the above range, the dosage form of the tablet does not collapse during production, transportation, and ingestion, and the dosage form has sufficient maintainability and can be applied to PTP packaging.

  The tablet of the present invention is not particularly limited with respect to its shape, size and the like. Examples of the shape include all shapes such as a round shape, an elliptical shape, a triangular shape, and a square shape. About a magnitude | size, it can be set as a dosage form about 5-20 mm in diameter and about 100-2,000 mg in weight, for example.

  The tablet may be an uncoated tablet (bare tablet), or a coated tablet having a surface coated for the purpose of stabilizing the tablet, taste-masking or flavoring. The coated tablets include sugar-coated tablets and film coating agents (gastric tablets, enteric tablets) coated with a film containing a water-soluble, enteric or gastric polymer base.

  The tablet is not limited in its use, and may be a pharmaceutical (including quasi-drug) or a food. Furthermore, the usage is not limited, and it may be a tablet for internal use or an oral tablet (troche tablet, buccal tablet, sublingual tablet, chewable tablet, orally disintegrating tablet).

  In the manufacturing process of the tablet of the present invention, the surface of glucosamine or a salt thereof is uniform compared to the conventional method of simply mixing by passing through a granulation step of wrapping glucosamine or a salt thereof with a calcium compound (calcium powder) in advance. And it is firmly coated with a calcium compound (calcium compound adheres).

  When tablets are produced by tableting using the oral composition of the present invention, the tablets are difficult to chip, the hardness is maintained, and the disintegration of the tablets is high.

  In the present invention, when a tablet is produced, an excipient is newly added when tableting is performed through a granulation step in which the surface of glucosamine or a salt thereof is previously coated with a calcium compound (calcium powder). Therefore, it is possible to produce a tablet having moderate disintegration property (short disintegration time) while increasing hardness.

  The food composition (tablet) of the present invention has a high blending ratio of glucosamine or a salt thereof, has a sufficient hardness, and exhibits excellent disintegration properties.

(Test 1) Tablet hardness measurement and disintegration test
Raw material used Glucosamine hydrochloride Calcium carbonate: Scallop powder (uncalcined shell shell (contains 94% or more calcium carbonate))
Fish extract (containing 10% by weight or more of anserine)
Chicken cartilage extract (containing more than 30% by weight of type II collagen)
L-Arginine
L-citrulline Crystalline cellulose Reduced maltose Sucrose fatty acid ester

<Preparation of tablets>
1． Production of granulated material (Example only)
Using a stirring and mixing granulator, glucosamine hydrochloride and calcium carbonate were mixed at a weight ratio of 100: 10, 100: 17, 100: 20, 100: 22.3, 100: 30, and 100: 40. The mixing conditions were VG-05 (Paurec Co., Ltd.) for the stirring and mixing granulator, blade rotation speed 100 rpm, cross screw 3,600 rpm.

  During mixing, an aqueous solution containing 15% by weight of reduced maltose was added so that the final content of reduced maltose in the composition was 0.5% by weight, and the mixture was stirred under the same conditions for 1 minute after the addition. Thereafter, using a fluidized bed granulator (MP-01, Powrec Co., Ltd.), drying was performed at an air supply temperature of 60 ° C and an exhaust temperature of 30 ° C. After drying until the moisture value became 1% by weight or less, it was sieved with a mesh size of 1.0 mm.

  When the obtained granulated product (Example 3) was observed with a scanning electron microscope, glucosamine hydrochloride was coated with calcium carbonate, and when the coverage of calcium carbonate was calculated by the method described above, 90% or more (Fig. 1).

2． According to the tableting tables 1 and 2, the composition was mixed. In the comparative example, glucosamine hydrochloride, calcium carbonate, and reduced maltose were mixed without granulation. Using the granulated material prepared in the above, it was mixed. After mixing, the tablet was tableted with 200 mg of sugar-coated ridge of 8φ (diameter 8 mm) and punching pressure of 10 kN to obtain tablets.

3． Hardness measurement and disintegration test The manufactured tablets were subjected to hardness measurement and disintegration test.

  The hardness was measured using a load cell type tablet hardness tester manufactured by Okada Seiko Co., Ltd.

  In the disintegration test, the disintegration time was measured at each n = 6, and the average value was calculated. The disintegration test was based on the Japanese Pharmacopoeia Manual, General Test Method, and the disintegration solution used water at 37 ° C.

Consideration of tablet hardness measurement and disintegration test Tablets (Examples 1 to 5) prepared using a granulated material in which glucosamine hydrochloride is coated with calcium carbonate are not coated with calcium carbonate. The tablet hardness was maintained as compared with the tablets contained in (Comparative Examples 1 to 5), and the disintegration time of the tablets could be shortened as the calcium carbonate ratio increased (FIGS. 2 and 3).

  Thus, by using a granulated product in which glucosamine hydrochloride is coated with calcium carbonate, a tablet having a high blending ratio of glucosamine or a salt thereof, sufficient hardness, and excellent disintegration can be produced. It was.

(Test 2) Discoloration test of composition (granulated product)
1． Preparation of Composition According to Table 3, the composition was mixed (the granulated product of Example 6 was produced in Test 1 above and the granulated product used in Example 3 was used).

2． The sample was allowed to stand for 5 days under the conditions of a color change test temperature of 50 ° C. and a relative humidity of 60%, and the degree of color change compared with that during production was evaluated. The evaluation was performed by a method in which 10 subjects were judged in 10 levels from 10 points (state of no discoloration) to 1 point (state of severe discoloration), and the average value was calculated.

Consideration of discoloration test A composition (Example 6) prepared using a granulated product obtained by coating glucosamine hydrochloride with calcium carbonate was a composition containing glucosamine hydrochloride in a state where it was not coated with calcium carbonate ( Compared with Comparative Example 6), discoloration could be suppressed.

(Test 3) Tablet discoloration test
1． Preparation of tablets According to Table 4, the composition was mixed (the granulated product of Example 7 was produced in Test 1 above and the granulated product used in Example 3 was used), and 300 mg of 8φ (diameter 8 mm). ) Of sugar coating R 杵, tableting was performed at a pressure of 10 kN.

2． The sample was allowed to stand for 5 days under the conditions of a color change test temperature of 50 ° C. and a relative humidity of 60%, and the degree of color change compared with that during production was evaluated. The evaluation was performed by a method in which 10 subjects were judged in 10 levels from 10 points (state of no discoloration) to 1 point (state of severe discoloration), and the average value was calculated.

Consideration of discoloration test A tablet (Example 7) prepared by using a granulated product coated with glucosamine hydrochloride with calcium carbonate is a tablet containing glucosamine hydrochloride not coated with calcium carbonate (Comparative Example). Discoloration could be suppressed compared to 7).

  According to the present invention, even if an amino acid material (L-arginine, L-citrulline, cartilage extract, fish meat extract, etc.) is contained, a carbohydrate material (glucosamine hydrochloride) is converted into a non-amino acid material (calcium carbonate, etc.). By coating with, an oral composition (tablet) that suppresses the Maillard reaction of the carbohydrate material and hardly changes its color can be produced.

(4) Formulation Example Tablets were prepared according to the formulation shown in Table 5.

  Glucosamine hydrochloride and uncalcined calcium were granulated in the same manner as in Example, using reduced maltose as a binder.

  310 mg of the mixed powder obtained by mixing the obtained granulated product and other components (other than shellac) was tableted with a sugar coating R 杵 having a diameter of 8φ (diameter 8 mm) and a punching pressure of 10 kN, and coated with shellac. The obtained product was a tablet having sufficient hardness and excellent disintegration property and hardly discolored.

Claims (13)

  An oral composition in which part or all of the surface of glucosamine or a salt thereof is coated with a calcium compound.   The oral composition according to claim 1, wherein the calcium compound is calcium carbonate.   The oral composition according to claim 1 or 2, wherein the calcium compound is a powder.   The oral composition in any one of Claims 1-3 which has the form of a granule or a tablet.   A granulated product in which part or all of the surface of glucosamine or a salt thereof is coated with a calcium compound.   The granulated product according to claim 5, wherein the calcium compound is calcium carbonate.   The granulated product according to claim 5 or 6, wherein the calcium compound is a powder product. A method for producing a granulated product containing glucosamine or a salt thereof and a calcium compound,
A method for producing a granulated product comprising a step of granulating by mixing glucosamine or a salt thereof and a calcium compound.   The method for producing a granulated product according to claim 8, wherein the calcium compound is calcium carbonate.   The method for producing a granulated product according to claim 8 or 9, wherein the calcium compound is a powder product. A method for producing a tablet containing glucosamine or a salt thereof and a calcium compound,
A tablet production method comprising a step of granulating by mixing glucosamine or a salt thereof and calcium powder, and a step of tableting the granulated product obtained in the step.   The manufacturing method of the tablet of Claim 11 whose said calcium compound is a calcium carbonate.   The tablet manufacturing method according to claim 11 or 12, wherein the calcium compound is a powder.