JP4651345B2 - Method for producing collagen-containing preparation - Google Patents

Description

  The present invention provides a collagen-containing preparation containing a high content of collagen as a health food such as granules, tablets, and capsules. After mixing the polymer base material impregnated with water and collagen, there is an advantage that collagen granules having a high content can be easily prepared by gradually adding a hydrophilic solvent.

  Collagen is a major component of biological proteins and has a water retention characteristic of the substance, so that a moisturizing effect on the skin surface is expected. Further, since the amount of collagen decreases with aging and causes wrinkles, cosmetic surgery is used to rejuvenate by injecting collagen into the skin. In addition, it has been used for purposes such as keeping it moisturized by blending it into skin creams and hair-washing preparations, taking advantage of its moisturizing properties. Recently, low molecular weight collagen with a molecular weight of 10 million or less has a high effect of penetrating and absorbing from the mucous membrane to smooth and rejuvenate the skin surface, and there are reports that the same effect can be expected even if collagen is absorbed in the body, The number of people who eat collagen foods is increasing.

  Collagen is a nutrient that is necessary for maintaining human health in this way, but it is powdery when trying to ingest collagen alone, so it sticks to the lips and mouth and is difficult to eat, so it dissolves in water. When trying to ingest, it was liable to become lumpy when dissolved, and it was difficult to obtain a uniform solution. Therefore, in order to efficiently ingest collagen as a food, it is necessary to process it into easy-to-ingest granules and tablets. However, since collagen itself has high moisturizing properties, it has a high viscosity even after addition, so that granules can be prepared. When water was added to collagen, dissolution started and the water was absorbed to form a cocoon or dumpling, making granulation difficult.

  In addition, if the granules are prepared using only an organic solvent in which collagen does not dissolve, the strength of the granules decreases, and the granules collapse during the filling process and transportation, making it difficult to ingest, or producing granules only with organic solvents, Since the bulk density of granules required for tableting cannot be obtained, a large amount of excipients must be mixed and processed, and a high content collagen food could not be produced. Further, even when a water-soluble solvent such as alcohol is used, if the alcohol concentration is 93% or less, at the same time as the addition, dissolution starts like water, and moisture is absorbed to form a cocoon or dumpling, making granulation difficult. If it exceeds 50%, the granule strength decreases. For this reason, usually, in order to produce a high content granule of collagen, it has been necessary to produce it using an expensive powder fluidized bed apparatus.

  On the other hand, oral cosmetics (see Patent Document 1) obtained by mixing azuki bean powder with an aqueous solution containing chitosan, organic acid and collagen, and collagen-chitosan mixed dispersion and food material are simultaneously extruded and continuously molded. Foods having a collagen film obtained in this way (see Patent Document 2) are known.

JP-A-7-107940 JP-A-4-262733

When producing high-content collagen-containing granules, tablets, and capsules, it is difficult to process high content due to the physicochemical properties of collagen itself, and when added to general foods, protein denaturation and taste changes There was a problem such as waking up.
Furthermore, the preparation of collagen granules requires an expensive powder fluidized bed apparatus and the like, and there is a problem that it is difficult to prepare collagen granules easily and inexpensively.

  In this way, processing into health foods such as granules, tablets and capsules can solve the problem of sticking and taste in the oral cavity, and it is inexpensive by preparing granules containing a high content of collagen. Therefore, there has been a demand for a collagen-containing preparation that can be easily ingested in a necessary amount.

Accordingly, as a result of various studies to solve the above problems, the present inventors have mixed collagen with a polymer substrate impregnated with water, and then gradually added a hydrophilic solvent to prepare uniform granules. And a method for preparing uniform granules by gradually adding a water-containing powder impregnated with water to a polymer base material after kneading collagen with a hydrophilic solvent, and completing the present invention. It was.
That is, the present invention

(1) A method for producing a collagen-containing preparation, comprising mixing a collagen with a polymer substrate impregnated with water and then adding a hydrophilic solvent to prepare uniform granules;
(2) A method for producing a collagen-containing preparation characterized by preparing a uniform granule by adding a polymer base material impregnated with water after kneading collagen with a hydrophilic solvent,
(3) The method for producing a collagen-containing preparation according to item (1) or (2), wherein the polymer base material is one or more selected from chitosan and cellulose.
(4) The method for producing a collagen-containing preparation according to any one of (1) to (3), wherein the hydrophilic solvent is ethyl alcohol,
(5) The method for producing a collagen-containing preparation according to any one of (1) to (4), wherein the preparation is a granule, a tablet or a capsule,
(6) A preparation obtained by the production method according to any one of (1) to (5) above,
(7) Food using the preparation according to (6) above,
About.

  Uniform collagen-containing granules can be produced by the production method of the present invention, and the granules are used to process into granules, tablets, and capsules, which can be safely and inexpensively applied to the lips and oral cavity. However, a preparation with a high collagen content that can be easily taken is obtained.

The method for producing the collagen-containing preparation of the present invention comprises:
(1) A method for producing a collagen-containing preparation, comprising mixing a collagen with a polymer substrate impregnated with water and then adding a hydrophilic solvent to prepare uniform granules;
(2) A method for producing a collagen-containing preparation characterized by preparing a uniform granule by adding a polymer base material impregnated with water after kneading collagen with a hydrophilic solvent,
Either way.
In addition, the addition of the hydrophilic solvent in the production method (1) of the present invention and the addition of the polymer base material impregnated with water in the production method (2) of the present invention are the stirring efficiency and production quantity of the mixer, the polymer Although it depends on the water retention capacity of the substrate, it is carried out in small portions over 5 to 60 minutes.
The preparation of the present invention is prepared by any of the methods described above, dried and sized, and then prepared into powder, granules, tablets, capsules and the like by a conventional method. The conditions for drying the preparation vary depending on the thermal stability of the compounding agent and the residual water content, but usually, the majority of the solvent is removed by air drying for about 30 minutes, followed by drying at 40 to 80 ° C. for 2 to 6 hours.

Collagen used in the production method of the present invention may be derived from any animal or plant that contains collagen, and can be any food. Generally, cow skin, pig skin, horse skin, bird skin, fish skin, fish scale, etc. Is mentioned.
The molecular weight of the collagen used in the production method of the present invention is not particularly limited, and may be any one of hundreds of thousands to hundreds of low molecules, but a low molecular collagen having a molecular weight of 7,000 or less is preferred.
As a method for obtaining collagen used in the production method of the present invention, it can be obtained as a general food material from Itoham, Nitta Gelatin, Raviger, Chisso and the like.
In the preparation of the present invention, the content of collagen is usually about 5 to 90%, preferably about 20 to 60% in the preparation, although it depends on the molecular weight of collagen.

The polymer base material used in the present invention may be any material that can retain moisture and can be used as a food. Starch, cereal flour, cereal bran pulverized product, chitin, chitosan, cellulose, hemicellulose, and gyudon Dietary fiber purified from various vegetables such as alginic acid, pectin, gelatin, guar gum, gum arabic, and water-absorbing polymer, etc., but preferably it does not dissolve in water at all like chitosan and cellulose, but also in a hydrophilic solvent Good thing not to do.
As a method for obtaining the polymer base material used in the present invention, general foods such as starch, cereal flour, and cereal bran pulverized products can be purchased at ordinary retail stores, etc., and chitin, chitosan, cellulose, hemicellulose, and gyudon Raw materials for processing such as dietary fiber purified from various vegetables such as alginic acid, pectin, gelatin, guar gum, gum arabic, and water-absorbing polymer are purchased from Yaizu Suisan Kogyo, Asahi Kasei, Nippon Kayaku Food Techno, Nitta Gelatin, etc. Can be obtained.
The content of the polymer base material in the preparation of the present invention varies depending on the water retention capacity of the base material, but is usually about 5 to 80%, preferably about 10 to 60%.

As the hydrophilic solvent used in the present invention, any solvent having an affinity for water may be used, and examples thereof include methyl alcohol, acetone, ethyl alcohol and the like. Ethyl alcohol is preferred for use as food.
The amount of the hydrophilic solvent used in the production method of the present invention varies depending on the water retention capacity and water content of the polymer substrate, but is usually about 5 to 500%, preferably about 100 to 300% with respect to the water content to be retained. It is.
As the hydrophilic solvent, for example, the amount of ethanol is usually 1 to 40%, preferably about 2 to 20% with respect to the amount of collagen.

  The water content in the polymer substrate in the state where the polymer substrate used in the present invention is impregnated with water varies depending on the water retention capacity of the polymer substrate, but the range in which moisture does not ooze out on the surface of the substrate particles The amount is usually 1 to 30%, preferably about 2 to 10% with respect to the amount of collagen.

In the preparation of the present invention, any preparation material may be blended as long as it is an edible component. For example, potato starch, cellulose, lactose, gum arabic, pullulan, corn starch, fish bone meal calcium and other excipients, and eggshell powder for the purpose of improving granule fluidity in the case of granules, tablets and capsules Further, lubricants such as whey calcium, glycerin fatty acid ester, and magnesium stearate powder may be used.
In the preparation of the present invention, the amount of the compounding agent to be added is usually about 1 to 80%, preferably about 20 to 60% in the preparation.

  The amount of the collagen-containing preparation of the present invention is not particularly limited, but it varies depending on the dosage form such as powder, granule, capsule, tablet, etc., but the collagen is preferably about 300 to 5000 mg per day, preferably about 500 to 3000 mg. Is good. More preferably, it is about 1000 mg to 2000 mg.

  When the collagen-containing preparation of the present invention is a tablet, it may be a bare tablet, a film-coated tablet, or a sugar-coated tablet. The capsule may be either a hard capsule or a soft capsule, and the hard capsule may be film coated. The granule may be used as it is, mixed with other agents and stick-wrapped, or any form as long as it is within the range of collagen intake per day.

  The size of the polymer substrate, collagen, and compounding agent particles used in the production method of the present invention may be 4 mesh pass or less, preferably 20 mesh pass or less, more preferably 40 mesh pass or less. What is not rough is good.

  The preparation of the present invention can be added to food in addition to eating directly as a granule, etc., and the addition to food can be sprinkled on yogurt, pudding, cakes, apricot tofu, fruit, etc. You can eat.

EXAMPLES The present invention will be specifically described below with reference to examples, but the present invention is not limited to these.

Example 1
To 70 kg of chitosan (manufactured by Nippon Kayaku Food Techno), 3 L of tap water was added and taken out into a SUS container as a uniform hydrous chitosan powder. Next, 150 kg of collagen having a molecular weight of 5000 (pig derived, Nitta gelatin), 4 kg of citric acid, 15 kg of bitter gourd extract powder, and 2 kg of sucralose were mixed, and then 4 L of ethyl alcohol was added and kneaded. While rotating the kneader, the previously prepared hydrous chitosan powder was gradually added to prepare collagen granules without lumps. After drying, the mixture was sized with a speed mill, and 57 kg of vitamin C, 7 kg of lemon flavoring powder, and 0.4 kg of biotin 1% preparation were added and mixed to obtain granules for tableting. This granule was tableted by a conventional method to obtain a tablet according to the present invention.

Example 2
Add 0.2 L of tap water to 7 kg of cellulose powder (Asahi Kasei) to obtain a uniform water-containing cellulose powder. Further, 0.4 kg of citric acid, 1.5 kg of astaxanthin 1% preparation, 0.2 kg of sucralose, 6 kg of vitamin C, vitamin B10. After mixing 1 kg of collagen having a molecular weight of 500 (derived from fountain scales, Raviger), 0.4 L of ethyl alcohol was gradually added and kneaded to prepare collagen granules free from lumps. After drying, the mixture was sized with a speed mill, and 0.7 kg of orange flavor powder was added and mixed to prepare granules.
The granule of the present invention was obtained by filling 2 g of this granule into a stick.

Example 3
Mix 5kg of cellulose powder (Asahi Kasei) and 2kg of chitosan (made by Yaizu Suisan), add 0.3L of tap water to make a uniform water-containing base powder, 0.3kg of malic acid, 2kg of Murasaki potato pigment preparation, aspartame 0 After mixing 1 kg, 7 kg of acerola fruit juice powder, and 16 kg of collagen (derived from fish scales, Chisso) with a molecular weight of 700, 0.5 L of ethyl alcohol was gradually added and kneaded to prepare collagen granules without lumps. After drying, the mixture was sized with a speed mill, and 0.1 kg of biotin 1% preparation and 0.7 kg of orange flavor powder were added and mixed to prepare granules. The granules were tableted by a conventional method and film-coated with shellac to obtain the tablets of the present invention.

Claims (5)

A collagen-containing preparation characterized by mixing collagen with a polymer base material selected from chitosan and cellulose impregnated with water , and then adding a hydrophilic solvent to prepare uniform granules. Production method.
A collagen-containing preparation comprising kneading collagen with a hydrophilic solvent and then impregnating with water , and adding a polymer base material of at least one selected from chitosan and cellulose to prepare uniform granules Manufacturing method.
The method for producing a collagen-containing preparation according to claim 1 or 2 , wherein the hydrophilic solvent is ethyl alcohol.
The method for producing a collagen-containing preparation according to any one of claims 1 to 3 , wherein the preparation is a granule, a tablet or a capsule.
The formulation obtained by the manufacturing method as described in any one of Claims 1 thru | or 4 .