JP7366306B1 - Method for manufacturing turmeric-containing tablets - Google Patents

Abstract

[Problem] To provide a manufacturing method that makes it possible to obtain turmeric-containing tablets that make use of essential oil components, which are useful components contained in turmeric, and to provide strength that does not easily lose shape or damage during distribution. Provided is a method for producing turmeric-containing tablets. [Solution] In a method for producing tablets containing four types of turmeric, purple turmeric, autumn turmeric, tropical turmeric, spring turmeric, and turmeric extract, turmeric powder and turmeric are mixed in equal proportions of each of the four types of turmeric. The surface of the extract is modified by wet coating using a cellulose derivative, and the surface of the surface-modified turmeric powder and turmeric extract is dry mixed with powdered maltose and fine silica gel. The method includes a step of modifying the surface, and a step of dry-mixing sucrose fatty acid ester to modify the surface. [Selection diagram] None

Description

The present invention relates to a method for manufacturing tablets containing turmeric and turmeric extract. More specifically, the present invention relates to a method for producing tablets having physical properties that allow practical use of turmeric powder and turmeric extract, which are difficult to compress.

Turmeric (Curcuma longa L.) is a medicinal plant of the ginger family that is native to India and is cultivated in tropical and subtropical regions around the world, mainly in Southeast Asia. The rhizomes are mainly used. Turmeric rhizomes contain 3-5% curcumin (yellow pigment). Curcumin is considered to be a typical active ingredient of turmeric that contributes to antioxidant capacity, improvement of liver function, and maintenance of liver function, and various formulations and manufacturing methods shown below have been disclosed.

Patent Document 1 is a soft tablet containing turmeric extract, and is a preparation consisting of turmeric extract, a gelling agent such as gelatin, a plasticizer such as glycerin, a releasing agent such as lecithin, a sweetener, a preservative, and a flavoring agent. It is an orally administered drug that can continuously deliver active ingredients over a long period of time to affected areas, not only the esophagus and gastrointestinal tract.
Patent Document 2 discloses a jelly containing turmeric and curcumin, characterized in that the gelling agent constituting the jelly consists of gellan gum and carrageenan, and is a jelly with a composition that gradually releases curcumin in the stomach and intestines.
Regarding masking the unpleasant taste of preparations containing turmeric etc., Patent Document 3 found that the unpleasant taste and off-taste of turmeric extract was greatly improved by adding carbonic acid, and the unpleasant taste and off-taste were reduced. This paper proposed a technology for creating a beverage containing turmeric extract.

Patent Document 4 discloses that the unpleasantness of edible compositions caused by functional materials such as turmeric is caused by the use of 30 mass dextrin made from potatoes, with a DE (dextrose equivalent) of 2 or more and 6 or less, and prepared with distilled water at 25°C. % aqueous solution for 5 minutes at 25°C using dextrin having a viscosity of 150 Pa·s or less.
Patent Document 5 discloses a method for improving odor and taste by heating turmeric powder, in which the curcumin content in turmeric after heating is 80% of the curcumin content in turmeric before heating. This is the heating method described above. As for the heat treatment method, it is stated in Examples that the effect was confirmed at 155° C. for 15 minutes.

In addition, Non-Patent Document 1 reports on the molding of tablets using turmeric, and many turmeric-related grain (tablet) products have lower tablet hardness than that of general pharmaceuticals, and their compression moldability is is not good. Generally, granules for tabletting are said to be suitable for the fluidized bed granulation method, the rolling fluidized bed granulation method, and the agitation granulation method, in that order. Therefore, granulation was performed using a fluidized bed granulation device using collagen peptide, sodium alginate, and hydroxypropyl cellulose as binders. When granulated with hydroxypropyl cellulose, the hardness tends to be in the order of autumn turmeric < spring turmeric < purple turmeric depending on the type of turmeric. The results showed that the tablet hardness of each granule differs depending on the product, and that the reason for this is the lipid content in turmeric more than the physical properties of the powder. Then, the lipid content of the above three types of turmeric was measured. The results showed that autumn turmeric had lower lipid content than spring turmeric. Here, when various types of turmeric were defatted with diethyl ether and tablets were made using the defatted powder, the tablet hardness of the defatted autumn turmeric powder was 9, whereas the tablet hardness of the autumn turmeric powder was 0.55 kgf. .10 kgf was obtained, and the tablet hardness was improved by 16.5 times (see Fig. 7 (from page 183 of Non-Patent Document 1)).

On the other hand, powdered maltose with low sweetness is used as a tableting excipient that is added to form tablets to obtain the formability and tabletability of the material. (registered trademark). According to the homepage of Non-Patent Document 2, Sunmalt (Midori) (registered trademark) is a carbohydrate suitable for low-pressure tableting and can be used for materials with poor moldability. It is stated that it is possible. Also shown is the tablet hardness when various carbohydrates are compressed into tablets.

Regarding Sunmalt (registered trademark), Non-Patent Document 3 further states that Sunmalt (Midori) (registered trademark) is a tablet product containing functional oil materials such as DHA due to its high oil retention ability. It shows the relationship between tableting pressure and tablet hardness when DHA is blended with dextrin or Sunmalt (registered trademark), which is said to be extremely effective in manufacturing, and the tablets are compressed.

Furthermore, Patent Document 6 states that in a method for producing a live bacteria preparation, in order to increase the residual rate of beneficial intestinal bacteria during production, a saccharide powder composition containing 60% by mass or more of maltitol (maltose) is used. It has been shown that a solid preparation can be produced by using 30 to 95% by mass and mixing this with beneficial intestinal bacteria. Here, as Example 1, Sunmalt (registered trademark) is used as the candy flour.

Further, in Patent Document 7, it is described in the claims and examples that Sunmalt (registered trademark) is used as a free water decomposition preventing material in a method for manufacturing a rice molded product.

Special table 2016-535028 publication Japanese Patent Application Publication No. 2017-197465 JP2015-65938A JP2015-128420A Japanese Patent Application Publication No. 2007-116945 Japanese Patent Application Publication No. 2016-193893 Japanese Patent Application Publication No. 02-060556

Yasuhiro Kamata, PHARM TECH JAPAN, vol. 28 No. 14 (2012) pp. 179-186 Hayashibara Co., Ltd. homepage, product introduction, Sunmalt (registered trademark), [searched on March 8, 2020], Internet [https://www.food.hayashibara.co.jp/product/sunmalt/] Food and Development, VOL. 48 NO. 8 (2013) pp. 72-73 Kamata et al., Development of tablet forming technology for turmeric, Okinawa Prefectural Industrial Technology Center Research Report No. 9 (2007)

However, since the above-mentioned technologies of Patent Documents 1 and 2 are semi-solid preparations using a gelling agent, special equipment is required for manufacturing, and the addition of preservatives and the like is required for storage. It has the disadvantage that it involves many steps, is complicated, and increases costs.
Further, Patent Document 3 describes a technology for masking the unpleasant taste of turmeric in beverages, and Patent Document 4 also lists tablets as a form, but in Examples, peptides are used as functional materials in the form of an aqueous solution to achieve a masking effect. It is evaluated. However, the masking effect of turmeric in tablet form has not been confirmed, and it cannot be said that it is easy to carry and ingest.
The method of Patent Document 5 requires special equipment such as an autoclave, and has the drawback of increasing the manufacturing process and manufacturing cost.

Furthermore, in Non-Patent Document 1, it is possible to improve the hardness of tablets, but in order to obtain that hardness, the turmeric powder is defatted, that is, the essential oil components contained in turmeric are removed. be. In other words, turmeric essential oil has pharmacological effects such as promoting bile secretion, promoting stomach health, sterilization, and antiseptic properties. This is undesirable as it cannot bring out the best in it. In Non-Patent Document 1, in a tablet containing autumn turmeric, for example, when the essential oil content of autumn turmeric is 1.3 mL/50 g, a tablet containing 95% autumn turmeric containing 330 mg of autumn turmeric has an essential oil content of 8.15 μL, Since the hardness of this tablet is as low as 2.7 kgf (see Non-Patent Document 4), in order to clarify the cause of this, we degreased the autumn turmeric powder with diethyl ether and made the defatted powder. When comparing the tablet hardness of the autumn turmeric powder, the tablet hardness of the defatted autumn turmeric powder was 9.10 kgf, while the tablet hardness of the defatted autumn turmeric powder was 9.10 kgf. It can be seen that with this powder, tablets with a tablet hardness 16.5 times higher than that of autumn turmeric powder can be obtained.However, by defatting autumn turmeric powder, the functions of autumn turmeric are lost, which is undesirable.Furthermore, Non-Patent Document 1 does not report on the stability of tablets over time.For tablets containing fat-soluble components such as essential oil components, tests and observations of tablet hardness and friability over time, that is, stability tests and long-term storage tests, are not available. becomes important.

Furthermore, in Patent Document 6, Patent Document 7, Non-Patent Document 2, and Non-Patent Document 3, there is no description of the use of turmeric for tableting, and in particular, in Non-Patent Document 2, there is no mention of the use of turmeric as a material with poor moldability. However, when making tablets containing a high content of turmeric, it was not possible to make tablets with high hardness and low friability using Sunmalt (registered trademark) alone.

In each of the above-mentioned Patent Documents 1 to 5 and Non-Patent Document 1, although there are examples of using turmeric powder, the essential oil components contained in turmeric are not utilized, and the useful components contained in this essential oil component are not utilized. Therefore, no specific consideration was given to obtaining preparations such as tablets.

Therefore, in order to solve the above-mentioned problems, the present invention aims to solve the problem of turmeric, which is said to be difficult to compress and mold into tablets that can withstand practical use. The purpose is to provide a manufacturing method that can obtain turmeric-containing tablets that take advantage of the There is.

Next, means for solving the above problem will be explained.
The method for producing a turmeric-containing tablet according to claim 1 of the present invention is a method for producing a tablet containing four types of turmeric: purple turmeric, autumn turmeric, tropical turmeric, spring turmeric, and turmeric extract.
100 parts of turmeric powder in which each of the four types of turmeric is mixed in the same ratio is charged into any of a stirring granulator, a fluidized bed granulator, or a rolling granulator and mixed uniformly, and the above-mentioned turmeric is uniformly mixed therein. Add 1 to 5 parts of turmeric extract and mix uniformly.
Here, 1 to 10 parts of a cellulose derivative aqueous solution is added to obtain surface-modified granules by wet coating,
After drying and sizing the granules to obtain sized granules,
To the sized granules, 1 to 10 parts of fine silica gel that has been previously sieved and deagglomerated, 1 to 10 parts of powdered maltose, and 1 to 5 parts of sucrose fatty acid ester that has been previously sieved and deagglomerated are added to the sized granules. Dry mixing in order to obtain a surface-modified mixed powder,
A feature of this method is that tablets are made from this mixed powder using a tablet press.

According to this method for producing turmeric-containing tablets, additives such as powdered maltose (for example, Sunmalt (registered trademark)), fine silica gel, sucrose fatty acid ester, and hydroxypropyl cellulose are added to four types of turmeric and turmeric extract. The cellulose derivatives are blended in a specific composition.

According to this method for producing turmeric-containing tablets, as a method for treating four types of turmeric powder with Sunmalt as a surface modifier, the surface of the turmeric extract is first modified into four types of turmeric powder by wet coating. Specifically, four types of turmeric powder and turmeric extract are put into a granulating device such as a stirring granulator, a fluidized bed granulator, or a rolling granulator, and then an aqueous solution of hydroxypropyl cellulose or the like is added to the granulator. A cellulose derivative aqueous solution is added and the surface is modified by wet coating. After drying this, it is sized. Surface-modified granules of four types of turmeric and turmeric extract are surface-modified by dry mixing using fine silica gel, powdered maltose (Sunmalt (registered trademark)), and sucrose fatty acid ester, respectively. Then, tablets are made from this surface-modified mixed powder using a tablet press.

In addition, according to this method for producing turmeric-containing tablets, each composition includes four types of turmeric powder, turmeric extract, powdered maltose (Sunmalt (registered trademark)), cellulose derivative (hydroxypropyl cellulose), fine silica gel, and The sucrose fatty acid ester is preferably 100 parts: 1 to 5 parts: 1 to 10 parts: 1 to 10 parts: 1 to 10 parts: 1 to 5 parts, more preferably 100 parts: 1 to 3 parts: 1 to 8 parts: 1 to 8 parts: 1 to 5 parts: 1 to 3 parts. This makes it possible to obtain turmeric-containing tablets that have an increased turmeric content compared to conventional tablets and have sufficient tablet hardness and low friability.

The method for producing a turmeric-containing tablet according to claim 2 is a method for producing a tablet containing four types of turmeric: purple turmeric, autumn turmeric, tropical turmeric, spring turmeric, and turmeric extract.
100 parts of turmeric powder in which each of the four types of turmeric is mixed in the same ratio is charged into any of a stirring granulator, a fluidized bed granulator, or a rolling granulator and mixed uniformly, and the above-mentioned turmeric is uniformly mixed therein. Add 1 to 5 parts of turmeric extract and mix uniformly.
Here, 1 to 10 parts of a cellulose derivative aqueous solution is added to obtain surface-modified granules by wet coating,
The granules are dried and sized to obtain sized granules, and
1 to 10 parts of fine silica gel that has been previously sieved and deagglomerated, 1 to 10 parts of powdered maltose, and 1 to 5 parts of sucrose fatty acid ester that has been previously sieved and deagglomerated are mixed in advance to form a mixed powder. Get,
Dry mixing the mixed powder with the sized granules to obtain a surface-modified mixed powder,
A feature of this method is that tablets are made from this surface-modified mixed powder using a tablet press.

According to this method for producing turmeric-containing tablets, powdered maltose (for example, Sunmalt (registered trademark)), fine silica gel, sucrose fatty acid ester, and hydroxypropyl cellulose are added to four types of turmeric and turmeric extract as additives. It is planned to be blended with a specific composition.

According to this method for producing turmeric-containing tablets, as a method for treating the four types of turmeric powder with Sunmalt (registered trademark) as a surface modifier, the surface of the turmeric extract is first modified into the four types of turmeric powder by wet coating. Specifically, four types of turmeric powder and turmeric extract are put into a granulating device such as a stirring granulator, a fluidized bed granulator, or a rolling granulator, and then an aqueous solution of hydroxypropyl cellulose or the like is added to the granulator. A cellulose derivative aqueous solution is added and the surface is modified by wet coating. After drying this, it is sized. In addition, fine silica gel that has been sieved and deagglomerated in advance, powdered maltose (Sunmalt (registered trademark: Hayashibara Co., Ltd.)), and sucrose fatty acid ester that has been sieved and deagglomerated are mixed in advance to form a mixed powder. get. Then, by dry blending the mixed powder into surface-modified sized granules containing the four types of turmeric and turmeric extract, and surface-modifying the powder, excellent turmeric-containing tablets having tablet physical properties sufficient for practical use are obtained. be able to.

In addition, according to this method for producing turmeric-containing tablets, each composition includes four types of turmeric powder, turmeric extract, powdered maltose (Sunmalt (registered trademark)), cellulose derivative (hydroxypropyl cellulose), fine silica gel, and The sucrose fatty acid ester is preferably 100 parts: 1 to 5 parts: 1 to 10 parts: 1 to 10 parts: 1 to 10 parts: 1 to 5 parts, more preferably 100 parts: 1 to 3 parts: 1 to 8 parts: 1 to 8 parts: 1 to 5 parts: 1 to 3 parts. This makes it possible to obtain turmeric-containing tablets that have an increased turmeric content compared to conventional tablets and have sufficient tablet hardness and low friability.

The method for producing a turmeric-containing tablet according to claim 3 is a method for producing a tablet containing four types of turmeric: purple turmeric, autumn turmeric, tropical turmeric, spring turmeric, and turmeric extract.
100 parts of turmeric powder in which each of the four types of turmeric is mixed in the same ratio is charged into any of a stirring granulator, a fluidized bed granulator, or a rolling granulator and mixed uniformly, and the above-mentioned turmeric is uniformly mixed therein. Add 1 to 5 parts of turmeric extract and mix uniformly.
Here, 1 to 10 parts of a cellulose derivative aqueous solution is added to obtain surface-modified granules by wet coating,
After drying and sizing the granules to obtain sized granules,
To the sized granules, 1 to 10 parts of fine silica gel that has been previously sieved and deagglomerated, 1 to 10 parts of powdered maltose, and 1 to 5 parts of sucrose fatty acid ester that has been previously sieved and deagglomerated are added to the sized granules. Dry mixing in order, further adding fine powder HPC, powdered cellulose, crystalline cellulose, and highly branched cyclic dextrin and dry mixing to obtain a surface-modified mixed powder,
A feature of this method is that tablets are made from this mixed powder using a tablet press.

According to this method for producing turmeric-containing tablets, four types of turmeric powder and turmeric extract are surface-modified by wet coating using a cellulose derivative aqueous solution (hydroxypropylcellulose aqueous solution), and then powdered maltose (Sunmalt (registered trademark) ), the surface is modified by dry mixing using fine silica gel and sucrose fatty acid ester.

Here, fine silica gel and sucrose fatty acid ester were combined with Cerny (registered trademark) SSL-SFP (trade name: Nippon Soda Co., Ltd.) as fine powder HPC, KC Flock (registered trademark: Nippon Paper Industries Co., Ltd.) as powdered cellulose, and crystalline Ceolus (registered trademark) OD-20F (trade name: Asahi Kasei Corporation) may be added as the cellulose, or cluster dextrin (registered trademark: Ezaki Glico Co., Ltd.) as the highly branched cyclic dextrin.

The method for manufacturing a turmeric-containing tablet according to claim 4 is a method for manufacturing a tablet containing four types of turmeric: purple turmeric, autumn turmeric, tropical turmeric, spring turmeric, and turmeric extract.
100 parts of turmeric powder in which each of the four types of turmeric is mixed in the same ratio is charged into any of a stirring granulator, a fluidized bed granulator, or a rolling granulator and mixed uniformly, and the above-mentioned turmeric is uniformly mixed therein. Add 1 to 5 parts of turmeric extract and mix uniformly.
Here, 1 to 10 parts of a cellulose derivative aqueous solution is added to obtain surface-modified granules by wet coating,
The granules are dried and sized to obtain sized granules, and
1 to 10 parts of fine silica gel that has been previously sieved and deagglomerated, 1 to 10 parts of powdered maltose, and 1 to 5 parts of sucrose fatty acid ester that has been previously sieved and deagglomerated are mixed in advance to form a mixed powder. Get,
Dry mixing the mixed powder with the sized granules,
Furthermore, fine powder HPC, powdered cellulose, crystalline cellulose, and highly branched cyclic dextrin are added to obtain a surface-modified mixed powder,
A feature of this method is that tablets are made from this surface-modified mixed powder using a tablet press.

According to this method for producing turmeric-containing tablets, four types of turmeric powder and turmeric extract are surface-modified by wet coating using a cellulose derivative aqueous solution (hydroxypropylcellulose aqueous solution), and then powdered maltose (Sunmalt (registered trademark) ), the surface is modified by dry mixing using fine silica gel and sucrose fatty acid ester.

Here, fine silica gel and sucrose fatty acid ester were combined with Cerny (registered trademark) SSL-SFP (trade name: Nippon Soda Co., Ltd.) as fine powder HPC, KC Flock (registered trademark: Nippon Paper Industries Co., Ltd.) as powdered cellulose, and crystalline Ceolus (registered trademark) OD-20F (trade name: Asahi Kasei Corporation) may be added as the cellulose, or cluster dextrin (registered trademark: Ezaki Glico Co., Ltd.) as the highly branched cyclic dextrin.

According to the method for producing turmeric-containing tablets according to claim 1 of the present invention, various useful effects of turmeric can be obtained together with the essential oil components contained in turmeric, and the surface modification is achieved by adding powdered maltose. The surface of the tablet is modified by adding fine silica gel and sucrose fatty acid ester to improve moldability, that is, to prevent tableting failure when molding the tablet with a tablet machine. can be obtained.

In addition, even though the tablets that are molded into products contain essential oil components, they have sufficient hardness and will not be damaged during the distribution process. In other words, the static strength of the tablet is such that it can withstand direct force applied during the manufacturing process or when handled by the user. Furthermore, the degree of abrasion, which is an indicator of ease of tablet breakage due to dropping or abrasion, is extremely low, and unlike conventional products, a portion of the tablet surface does not chip or peel. In other words, the dynamic strength of the tablet is the strength to withstand external forces such as vibrations during transportation such as handling during the distribution process. The oozing of essential oil components inside the tablet causes a decrease in the bonding force between powder particles, resulting in a decrease in tablet hardness and an increase in friability, but the turmeric-containing tablets obtained by the manufacturing method of the present invention do not have these problems. There is no occurrence of Moreover, surface-modified granules can be obtained more easily by the granulation device. From these facts, it becomes possible to obtain excellent turmeric-containing tablets having tablet physical properties that are sufficient for practical use.

According to the method for producing a turmeric-containing tablet of the present invention, it is possible to obtain a tablet in which the essential oil component having the useful action of turmeric and the turmeric extract are sufficiently contained in the composition ratio, and It is possible to obtain turmeric-containing tablets that have sufficient tablet hardness, low friability, and sufficient practicality such as ease of distribution as tablets.

According to the method for producing turmeric-containing tablets according to claim 2 of the present invention, powdered maltose, fine silica gel, and sucrose fatty acid ester are mixed in advance into sized granules whose surface has been modified by a granulation device. By adding the turmeric extract as a powder, the surface is modified by dispersing it more uniformly than by mixing each component and modifying the surface, which reduces the effect of the turmeric extract on the tablet hardness. Turmeric-containing tablets of better quality can be easily obtained.

In addition, in terms of the blending ratio of the composition, it is possible to obtain tablets that sufficiently contain the essential oil components and turmeric extract that have the useful effects of turmeric, and also have sufficient tablet hardness and low friability. , it is possible to obtain turmeric-containing tablets with sufficient practicality such as distribution as tablets.

According to the method for producing turmeric-containing tablets according to claim 3 of the present invention, fine silica gel that has been sieved and deagglomerated in advance, powdered maltose, and powdered silica gel that has been sieved and deagglomerated in advance are added to the sized granules. By dry-mixing the sugar fatty acid esters in order, and then adding and dry-mixing finely divided HPC, powdered cellulose, crystalline cellulose, and highly branched cyclic dextrin, a surface-modified mixed powder is obtained. Furthermore, tablets containing turmeric can be obtained by increasing the tablet hardness.

According to the method for producing turmeric-containing tablets according to claim 4 of the present invention, the sized granules are obtained by sifting, and fine silica gel which has been sieved and deagglomerated in advance, and powdered maltose which has been sieved and deagglomerated in advance are mixed together. Deagglomerated sucrose fatty acid ester is mixed in advance to obtain a mixed powder, and sized granules are dry-mixed to this mixed powder, and fine HPC, powdered cellulose, crystalline cellulose, and highly branched cyclic dextrin are added. By using this procedure to obtain a surface-modified mixed powder, it is possible to further increase the tablet hardness and obtain turmeric-containing tablets.

The turmeric-containing tablet of the present invention is a tablet containing powders of four types of turmeric, purple turmeric, tropical turmeric, autumn turmeric, and spring turmeric, and turmeric extract, and turmeric extract is added to these four types of turmeric powder. Powdered maltose, fine silica gel, sucrose fatty acid ester, and cellulose derivative are used as surface modifiers in a specific composition, and the cellulose derivative is surface modified by wet coating. This product is obtained by a manufacturing method in which the granules are made into granules, the granules are surface-modified by dry mixing powdered maltose, fine silica gel, and sucrose fatty acid ester, and the granules are compressed into tablets. .
In this manufacturing process, the cellulose derivative is preferably hydroxypropylcellulose, and the powdered maltose is preferably Sunmalt (registered trademark: Hayashibara Co., Ltd.), which has sufficient hardness and friability as a tablet for practical use. A moisturizing turmeric-containing tablet can be obtained.

In addition, in surface modification by dry mixing, fine silica gel and sucrose fatty acid ester were combined with fine HPC (Celny (registered trademark) SSL-SFP (trade name: Nippon Soda Co., Ltd.)) and powdered cellulose (KC Flock (registered trademark)). : Nippon Paper Industries Co., Ltd.)), crystalline cellulose (CEOLUS (registered trademark) OD-20F (product name: Asahi Kasei Corporation)), or cluster dextrin (registered trademark: Ezaki Glico Co., Ltd.) as a highly branched cyclic dextrin. You can also do it.

The characteristics of turmeric and turmeric extract in the present invention are as follows.
There are four types of turmeric used in the present invention: autumn turmeric, spring turmeric, purple turmeric, and tropical turmeric. In Chinese medicine, it is used as a choleretic, stomachic, diuretic, hemostatic, and menstrual medicine.
Autumn turmeric contains essential oil components and curcumin. Curcumin's effects can be expected to strengthen liver function, promote digestion, and increase appetite.
Spring turmeric has dietary fiber, minerals, and essential oils that provide moderate stimulation to the intestines, which improves stomach health.
Purple turmeric, also known as gajutsu, is aromatic, has a bitter taste, and is used as an aromatic gastrointestinal because it stimulates the digestive system.
Tropical turmeric has a high content of essential oil components and curcumin.

According to the comparison of cultivation and measurement results by the applicant, the essential oil components are 1.3 mL/50 g for autumn turmeric harvested in 2021 and 2022, and 2.8 to 3.4 mL/50 g for tropical turmeric. The essential oil content was about 2 to 3 times that of autumn turmeric.
In addition, in a comparison of total curcuminoids including curcumin, autumn turmeric harvested in 2021 and 2022 was 0.461-0.612%, and tropical turmeric was 5.5-5.8%, compared to autumn turmeric. Tropical turmeric obtained approximately 9 to 10 times more results. Therefore, we can expect high effects from curcumin in tropical turmeric.
For reference, the total curcuminoids of spring turmeric and purple turmeric were 0.08 to 0.233% and 0 to 0.0007%.

The turmeric extract used in the present invention is an ethanol extract of autumn turmeric and contains 95% curcuminoids. By incorporating this turmeric extract into tablets, high effects from curcumin can be expected. This curcumin has hepatoprotective action, antioxidant action, antitumor action, immunostimulatory action, anti-inflammatory action, and antibacterial action.
Curcumin is sparingly soluble in water, is light-resistant and sensitive to ultraviolet rays, and darkens in the presence of trace amounts of metals, especially iron ions. Moreover, an alcohol or diethyl ether solution exhibits a bright yellow color. Note that curcuminoids are also poorly soluble in water and are ethanol-soluble compounds.
Curcuminoids are a type of polyphenol and are mainly classified into three types: curcumin, demethoxycurcumin, and bisdemethoxycurcumin.

Cellulose derivatives used as binders for the turmeric-containing tablets of the present invention include hydroxypropylcellulose (HPC), methylcellulose (MC), carboxymethylcellulose (CMC/carmellose), and hydroxypropylmethylcellulose (HPMC/hypromellose).

In addition, the fine silica gel constituting the additive includes fine silicon dioxide, fine powder silica (Silopage (registered trademark: Fuji Silysia Chemical Co., Ltd.), light anhydrous silicic acid (Aerosil 200 (registered trademark: Nippon Aerosil Co., Ltd.), Examples include Ad Solider 101 (registered trademark: Freund Sangyo Co., Ltd.).

Furthermore, as the sucrose fatty acid ester constituting the additive, sucrose stearate (S-370, S-370F, S-1170, S-1170F (product name: Mitsubishi Chemical Corporation)), sucrose behenic acid Ester (B-370, B-370F (product name: Mitsubishi Chemical Corporation)), sucrose mixed fatty acid ester (POS-135 (product name: Mitsubishi Chemical Corporation)), etc. are used.

Furthermore, in the turmeric-containing tablet of this embodiment, stabilizers, flavoring agents, sweeteners, etc. can be added in addition to these.

The turmeric-containing tablet of the present invention configured in this manner can be applied not only to the health food field but also to the fields of foods, pharmaceuticals, quasi-drugs, and the like. Further, as for the dosage form, tablets are most preferable, but capsules, granules, fine granules, powders, etc. can also be used.

The turmeric-containing tablet of the present invention configured as described above is a tablet containing four types of turmeric: autumn turmeric, spring turmeric, purple turmeric, and tropical turmeric. The essential oil content of turmeric harvested in 2021 and 2022 is 1.3 mL/50 g for autumn turmeric, 0.8-1.1 mL/50 g for spring turmeric, 0.5-0.7 mL/50 g for purple turmeric, and 0.5-0.7 mL/50 g for tropical turmeric. It was 2.8 to 3.4 mL/50 g. The essential oil content of tropical turmeric was approximately 2 to 3 times that of autumn turmeric. Based on this result, the essential oil content per tablet (330 mg) is calculated to be 9.2 μL. In addition, the turmeric extract blended in addition to the four types of turmeric is an ethanol extract of autumn turmeric and is 95% curcuminoid, with 5% believed to be fat-soluble components such as fats and oils and fatty acids. The fat-soluble component derived from turmeric extract is 0.3 mg per tablet.

The turmeric-containing tablet of the present invention has an essential oil content of 9.2 μL per tablet (330 mg), which is more than 10% higher than the tablet containing 95% turmeric in Non-Patent Document 1, and furthermore, the turmeric-containing tablet of the present invention has an essential oil content of 9.2 μL per tablet (330 mg). The tablets contained 0.3 mg of fat-soluble components derived from turmeric extract per tablet, and had high hardness of 6 kgf or more.

The turmeric-containing tablet of the present invention has a higher essential oil content and fat-soluble components than the 95% turmeric-containing tablet shown in Non-Patent Document 1 without defatting the turmeric powder. We have established a tableting technology that has tablet hardness more than twice that of the turmeric-containing tablet shown in Patent Document 1.

Therefore, the turmeric-containing tablet of the present invention can obtain the various useful effects of turmeric together with the essential oil components contained in turmeric, is surface-modified by adding powdered maltose, and further contains fine silica gel and sucrose. By adding fatty acid ester, the surface is modified and moldability is improved, which means that when tablets are molded using a tablet machine, tableting failure can be prevented, and essential oil components are added to the molded tablets. It has sufficient hardness even when it is contained, has a hardness of 5 kgf or more, does not cause damage during the distribution process, etc., and is an indicator of the ease with which the tablet will break due to falling or abrasion. An excellent turmeric product that has an extremely low concentration of 0.5% or less, does not cause part of the tablet surface to be missing or peels off like conventional products, and has tablet physical properties that can withstand practical use. It becomes possible to manufacture tablets containing

Furthermore, although the turmeric-containing tablet of the present invention contains an essential oil component, it is constructed with sufficient hardness, so it does not easily break as described above and is almost never abraded. For this reason, conventional turmeric-containing tablets were degreased to obtain hardness as shown in Non-Patent Document 1, but the turmeric-containing tablets of the present invention contain essential oil components, which are useful components. It is obtained as a tablet in a hard state, and can be taken as turmeric powder, which has pharmacological effects such as promoting bile secretion, promoting stomach health, sterilizing, and preservative, which the essential oil component has. There is no possibility of damage due to external forces caused by time.

In addition, the turmeric-containing tablet of the present invention has the effect of stabilizing the content of essential oil components (turmeric extract) such as curcumin due to the porous nature of Sunmalt (registered trademark) as powdered maltose blended as an additive. As a result, stability over time can be obtained, and it is possible to suppress the possibility of deterioration of the tablet over time, that is, a decrease in hardness or an increase in friability over time.
Furthermore, surface modification by adding fine silica gel and sucrose fatty acid ester in addition to powdered maltose improves the formability into tablets and avoids tableting problems.

Next, a method for manufacturing the above-mentioned turmeric-containing tablet will be explained.
First, the powders of four types of turmeric, autumn turmeric, spring turmeric, purple turmeric, and tropical turmeric, are uniformly mixed together with turmeric extract using a stirring granulation device at equal mixing ratios. Note that in addition to the stirring granulator, a fluidized bed granulator or a rolling granulator may be used.

Next, the above mixed powder is wet coated with a solution of a cellulose derivative previously dissolved in water. The cellulose derivative is hydroxypropylcellulose.

Next, the granules whose surface has been modified by this wet coating are dried using a dryer.

Next, the dried granules are sized using a sizing machine to obtain sized granules.

Next, fine silica gel, powdered maltose, and sucrose fatty acid ester are added to the sized granules, and the surface is modified by dry mixing.
Here, fine powder HPC, crystalline cellulose, and highly branched cyclic dextrin may be further added and the surface modified by dry mixing.

Next, tablets are made from the surface-modified granules using a tablet press.

Here, the blending ratio of each composition is 100 parts of four types of turmeric powder, 1 to 5 parts of turmeric extract, 1 to 10 parts of powdered maltose, 1 to 10 parts of cellulose derivative, and 1 to 1 part of fine silica gel. 10 parts, and 1 to 5 parts of sucrose fatty acid ester. Preferably, 100 parts of four types of turmeric powder, 1 to 3 parts of turmeric extract, 1 to 8 parts of powdered maltose, 1 to 8 parts of cellulose derivative, 1 to 5 parts of fine silica gel, and sucrose fatty acid Use 1 to 3 parts of ester. As a result, it is possible to obtain a turmeric-containing tablet having sufficient tablet hardness and low friability while having a compounding ratio in which the turmeric content is increased compared to the conventional one.

According to the method for producing turmeric-containing tablets of the present invention, after surface-modifying turmeric powder and turmeric extract with a cellulose derivative aqueous solution, which is a water-soluble polymer solution, by a wet coating method, the turmeric powder and turmeric extract are The surfaces of the turmeric-containing granules were further modified by dry mixing fine silica gel and sucrose fatty acid ester to the surface-modified granules.
Regarding this surface modification, in ``Application of surface modification method to standard formulations'' by Kato et al. An example is shown in which surface modification is performed by mixing all at once with light silicic anhydride, but in the production method of the present invention, the surface of turmeric as the main component is modified in advance by a wet coating method. Turmeric-containing granules were further surface-modified using powdered maltose, fine-grained silica gel, and sucrose fatty acid ester using a dry mixing method, and the optimal mixing ratio of powdered maltose, fine-grained silica gel, and sucrose fatty acid ester was determined. By doing so, it was possible to obtain tablets that contained turmeric extract and had sufficient hardness and low friability.

Note that various ingredients can be blended into the turmeric-containing tablet of the present invention depending on the intended use.
For example, functional materials include evening primrose, chrysanthemum flowers, soybean isoflavones, agarisque, saw palmetto, yam leaves, red malt, docosahexaenoic acid, resveratrol, lactoferrin, salacia, glucosamine, polyphenols, collagen, peptides, coenzyme Q10, kale, and amino acids. , ginkgo biloba, reishi, vitamins, minerals, GABA, astaxanthin, propolis, royal jelly, spirulina, chlorella, and the like may be included.

In the pharmaceutical field, antihistamines such as chlorpheniramine maleate, diphenhydramine hydrochloride, and promethazine; antitussive expectorants such as dextromethorphan hydrobromide, guaifenesin, and theophylline; antihypertensive agents such as captryl, methyldopa, and labetalol hydrochloride; Antiarrhythmic agents such as pindolol, propranolol hydrochloride, and procainamide hydrochloride; diuretics such as isosorbide and furosemide; antispasmodics such as scopolamine hydrobromide and papaverine hydrochloride; stomachic digestive agents such as roto extract, diastase, and cinnamon bark oil; Intestinal regulating agents such as berberine, lactic acid bacteria, and bifidobacteria; antacids such as magnesium oxide, magnesium carbonate, and sucralfate; _H2 receptor blockers such as cimetidine, ranitidine, and famotidine; antipyretic, analgesic, and antiinflammatory agents such as acetaminophen, ibuprofen, and ethenzamide. Medicinal ingredients may include drugs, hypnotic sedatives such as diazepam, nitrazepam, and phenobarbital sodium, and antidepressants such as amphetamine and imipramine.

Furthermore, nourishing and tonic health medicines include naturally derived substances such as herbal medicines and Chinese herbal medicines, proteins, amino acids, and minerals such as iron, calcium, and magnesium. Vitamins such as vitamin A, vitamin B ₁ , vitamin B ₂ , vitamin B ₆ , vitamin B ₁₂ , vitamin C, and vitamin E may also be included.

Next, specific examples of the above-described embodiment will be described.
<Comparative example>
First, as a comparison with the turmeric-containing tablet of the present invention, comparative tablets containing four types of turmeric powder as main ingredients without turmeric extract are prepared.
Table 1 shows the blending amount for each tablet physical property.

As comparative tablets, seven examples A-1 to A-7 were combined in different amounts. As the main ingredients of these tablets, four types of turmeric are mixed in equal amounts, each at 23.5% by weight, and the total amount is 94.0% by weight. In addition, the composition includes 3.0% or 1.5% by weight of hydroxypropyl cellulose as a cellulose derivative, 2.0% by weight of fine silica gel, and 1.0% by weight of sucrose fat fatty acid ester.

As a procedure for manufacturing this comparative tablet, first, four kinds of turmeric powders were put into a stirring granulator.
Next, an aqueous hydroxypropyl cellulose solution is added thereto, wet-coated to form granules, and the granules are dried at 60° C. to a water content of 3% or less.
Next, the dried granules are sized using a Cormill (1.14 mm diameter screen, round impeller).
Next, the sized granules were put into a plastic bag, and fine silica gel, which had been sieved through a 20-mesh screen in advance, was dry-mixed therein, and then sucrose fatty acid ester, which had been sieved through a 30-mesh screen in advance, was added thereto. Dry mix in a bag.
Next, this mixed powder is compressed into tablets using a rotary tablet machine, each tablet weighing 350 mg, the dosage form being 9 mmφAR, and the rotation speed being 30 rpm.

In this manufacturing procedure, the following weight percentages of each of the tablets of Comparative Examples A-1 to A-7 are combined.
In Comparative Examples A-1, A-4, and A-6, hydroxypropylcellulose is 3.0% by weight. In Comparative Examples A-2, A-3, A-5, and A-7, hydroxypropylcellulose is 1.5% by weight. In these Comparative Examples A-2, A-3, A-5, and A-7, 2.5% by weight of finely powdered HPC was added. In Comparative Example A-3, fine silica gel and sucrose fatty acid ester were added to fine HPC, and in A-5 and A-7, fine HPC was added to fine silica gel and sucrose fatty acid ester. In A-4 and A-5, 5.0% by weight of highly branched cyclic dextrin is added. In A-6 and A-7, 5.0% by weight of powdered maltose was added.
The following fine silica gel, sucrose fatty acid ester, fine HPC, highly branched cyclic dextrin, and powdered maltose were used.
Fine silica gel (silicon dioxide): Silopage (registered trademark: Fuji Cereal Chemical Co., Ltd.)
Sucrose fatty acid ester: Sugar ester B-370F (product name: Mitsubishi Chemical Corporation)
Fine powder HPC: Cerny SSL-SFP (registered trademark: Nippon Soda Co., Ltd.)
Highly branched cyclic dextrin: Cluster dextrin (registered trademark: Ezaki Glico Co., Ltd.)
Powdered maltose: Sunmalt (Midori) (registered trademark: Hayashibara Co., Ltd.)

<Example>
Next, as examples of turmeric-containing tablets of the present invention, five examples will be created by changing the blending amounts of each component.
Table 2 shows the blending amount for each tablet physical property.

The five examples of Examples 1 to 5 were combined as turmeric-containing tablets with different amounts.The main ingredients of these tablets were 4 types of turmeric in equal amounts, each at 23.5% by weight. The total amount is 94.0% by weight, and the turmeric extract is 2.0% by weight. To this, 3.0% or 1.5% by weight of hydroxypropyl cellulose as a cellulose derivative, 2.0% by weight of fine silica gel, 1.0% by weight of sucrose fat fatty acid ester, and 5.0% by weight of powdered maltose. The composition is expressed as % by weight.
In Examples 1 and 2, hydroxypropylcellulose was 3.0% by weight, and in Examples 3, 4, and 5, hydroxypropylcellulose was 1.5% by weight. In these Examples 3, 4, and 5, in Example 3, 2.5% by weight of finely powdered HPC, in Example 4, 2.5% by weight of powdered cellulose, and in Example 5, 2.5% by weight of crystalline cellulose, Each was added. In Examples 1 to 5, the weight of each tablet was 330 mg.

As a manufacturing procedure for this turmeric-containing tablet, first, four types of turmeric powder are put into a stirring granulator and mixed uniformly, and then a turmeric extract is added thereto and mixed uniformly.
Next, an aqueous hydroxypropyl cellulose solution is added thereto, wet-coated to form granules, and the granules are dried at 60° C. to a water content of 3% or less.
Next, the dried granules are sized using a Cormill (1.14 mm diameter screen, round impeller) to obtain sized granules. Next, the sized granules are placed in a plastic bag, and fine silica gel that has been sieved in advance, sucrose fatty acid ester, and powdered maltose are added thereto and dry mixed in the plastic bag.
Next, this mixed powder is compressed into tablets using a rotary tablet machine, each tablet weighing 330 mg, the dosage form being 9 mmφAR, and the rotation speed being 30 rpm.

In Example 1, each component of fine silica gel, powdered maltose, and sucrose fatty acid ester is mixed in dry mixing. In Example 2, the three components of fine silica gel, sucrose fatty acid ester, and powdered maltose are mixed in advance, and the mixed powder is put into sized granules and dry mixed. In addition, in Examples 1 and 3 to 5 except for this Example 2, the sized granules were put into a plastic bag, fine silica gel, powdered maltose, fine HPC, highly branched cyclic dextrin, powdered cellulose, crystalline cellulose, and chocolate were added. The sugar fatty acid esters were dry mixed for each component.
The fine silica gel, sucrose fatty acid ester, fine HPC, highly branched cyclic dextrin, maltose powder, cellulose powder, and crystalline cellulose used above were shown below.
Fine silica gel (silicon dioxide): Silopage (registered trademark: Fuji Cereal Chemical Co., Ltd.)
Sucrose fatty acid ester: Sugar ester B-370F (product name: Mitsubishi Chemical Corporation)
Fine powder HPC: Cerny SSL-SFP (registered trademark: Nippon Soda Co., Ltd.)
Highly branched cyclic dextrin: Cluster dextrin (registered trademark: Ezaki Glico Co., Ltd.)
Powdered maltose: Sunmalt (Midori) (registered trademark: Hayashibara Co., Ltd.)
Powdered cellulose: KC flock (registered trademark: Nippon Paper Industries Co., Ltd.)
Crystalline cellulose: Ceolus (registered trademark) OD-20F (product name: Asahi Kasei Corporation)
In addition, each compounding amount of each of the above-mentioned Examples does not limit the present invention.

<Example of comparative study of the above comparative example and the above example>
Next, Comparative Examples A and B will be shown as Comparative Examples A and B, which are different from each of the Comparative Examples and Examples described above, but do not contain any of the additives.
<Comparative example A>
Comparative Example A was prepared as a turmeric-containing tablet without adding the additives fine HPC, fine silica gel, sucrose fatty acid ester, highly branched cyclic dextrin, and powdered maltose to Comparative Examples A-1 to A-7 described above. This is what I did.
Specifically, with a composition consisting of 94.0% by weight of 4 types of turmeric and 3.0% by weight of hydroxypropyl cellulose, the 4 types of turmeric were put into a stirring granulator, and an aqueous solution of hydroxypropyl cellulose was added to the powder. Addition, wet coating and drying of the granules at 60° C. to a moisture content of less than 3%. The dried granules were sized using a Cormill (1.14 mm diameter screen, round impeller, 15 Hz), and the sized granules were compressed into tablets using a rotary tablet machine at a rotation speed of 30 rpm, each tablet weighing 350 mg. Tablets with a dosage form of 9 mmφAR were manufactured.
Note that the rotation speed: 1 Hz = 60 rpm.

<Comparative example B>
Comparative Example B is a turmeric-containing tablet prepared in Examples 1 to 5 described above without adding the additives finely powdered HPC, finely divided silica gel, sucrose fatty acid ester, powdered maltose, and crystalline cellulose. .
For this tablet, four types of turmeric and turmeric extract are put into a stirring granulator, a hydroxypropylcellulose aqueous solution is added to this powder, wet coating is carried out, and after drying and sizing, powdered maltose is added and the above-mentioned Tablets were made in the same manner as in Comparative Example A. However, the weight of one tablet is 330 mg.

<Evaluation of comparative examples and examples>
Tablet hardness and friability of the tablets of Comparative Examples A-1 to A-7 and Comparative Example A immediately after manufacture were measured. The results are shown in Tables 3 and 4.

In addition, the tablets of Examples 1 to 5 and Comparative Example B immediately after manufacture were compared in terms of tablet hardness, friability, disintegration time, and tablet moisture. These results are shown in Tables 5-8.

Tablet hardness was evaluated using a tablet hardness meter SmartTest50 ST-50 (manufactured by Freund Sangyo Co., Ltd.) as an average value of 20 tablets.
Friability was measured using a tablet friability tester (manufactured by Toyama Sangyo Co., Ltd.: TFT-120) at 25 rpm for 15 minutes (sample mass: 10 g).
The disintegration time was evaluated using a tablet disintegration tester NT-610 (manufactured by Toyama Sangyo Co., Ltd.) using water as the test liquid, using 6 tablets.
Tablet moisture was measured and evaluated at 60° C. for 20 minutes (sample weight 10 g) using an infrared moisture meter (manufactured by Kett Scientific Research Institute, Inc.: FD-600-2).

In Comparative Examples A-1 to A-7 shown in Table 3 from each test result, the tablet hardness was about 5 to 9 kgf, except for Comparative Example A-2, and the tablet hardness of Comparative Example A was about 2 kgf.
Among these Comparative Examples A-1 to A-7, Comparative Examples A-6 and A-7, which were surface-modified by adding powdered maltose (Sunmalt), had a tablet hardness of about 6 to 9 kgf, which was the same as that of Comparative Example A. It was ~4 times higher.
From this, it was found that hardness can be improved by adding powdered maltose (Sunmalt) as an additive to perform surface modification. That is, it was found that adding powdered maltose (Sunmalt) was effective as a turmeric-containing tablet, and the tablets shown in Examples 1 to 5 and Comparative Example B were prepared and evaluated in the respective tests.

In Examples 1 to 5 shown in Table 5 of turmeric-containing tablets containing powdered maltose (Sunmalt), the tablet hardness was about 6 to 7 kgf, and in Comparative Example B, the tablet hardness was about 3 kgf.
Compared to Comparative Example B, which contains turmeric extract and uses powdered maltose (Sunmalt) alone as an additive, fine silica gel (Silopage) and sucrose fatty acid ester (Sugar Ester) are added together with this powdered maltose (Sunmalt). However, it can be seen that in Examples 1 to 5 of the turmeric-containing tablets formed by surface modification, the tablet hardness was more than twice as high as that of Comparative Example B. That is, by adding powdered maltose (Sunmalt), fine silica gel (Silopage), and sucrose fatty acid ester (Sugar Ester), it was possible to obtain sufficient hardness for tablets.

<Time-dependent test results of comparative examples and examples>
Next, test results of changes over time of each tablet of each of the above-mentioned Examples and Comparative Examples will be shown.
The tablets of Comparative Example A and Comparative Example B, Comparative Examples A-1 to A-7, and Examples 1 to 5 were each placed in an aluminum bag, heat-sealed to seal, and heated at 40°C and 75RH%. saved.
Tablets that had been sealed and stored were opened and taken out after one week, and tablets that were opened and taken out after one month, and their tablet hardness and friability were measured. After taking out the tablets, the aluminum bag was heat-sealed for restorage.
Table 3 shows the measurement results of tablet hardness and friability over time for Comparative Example A, Comparative Examples A-1 to A-7, and Comparative Example B and Examples 1 to 5 after one week and one month, respectively. 6. The test method was as described above.

First, from each test result, for Comparative Examples A-1 to A-7, after one month of storage period, compared to the start of the test, except for Comparative Examples A-2, A-5, A-6, and A-7. All tablet hardness decreased. In particular, it can be seen that Comparative Example A-2 has a low tablet hardness of 3 to 4 kg, and does not contain any additives. Furthermore, in Comparative Example A-5, a slight decrease was observed after one week. On the other hand, in Comparative Examples A-6 and A-7, it was confirmed that the tablet hardness tended to increase over time.
Therefore, it was found that using powdered maltose (Sunmalt), which was used as an additive in Comparative Examples A-6 and A-7, improved the hardness. Tablet physical properties over time were observed in Examples 1 to 5 in formulations containing turmeric extract (see Tables 5 to 8).

Next, regarding the hardness of the turmeric-containing tablets of each Example, compared to Comparative Example B which does not contain each additive, in Examples 1 to 5, the tablet hardness was approximately twice as high even after aging. was gotten. As mentioned above, compared to Comparative Example B, which contains turmeric extract and used powdered maltose (Sunmalt) alone as an additive, this powdered maltose (Sunmalt), fine silica gel (Silopage), sucrose fatty acid ester ( The tablets of Examples 1 to 5 in which each of the sugar esters (sugar esters) were added had sufficient hardness as a result of aging.

Among these Examples, in Examples 1 and 4, a slight decrease in tablet hardness was observed after one month of storage. Regarding Examples 2 and 5, a slight decrease was observed after one week of storage, but after one month of storage, the tablet hardness slightly increased compared to the starting point (see Table 5).
Example 1 and Example 2 have the same formulation, and the manufacturing method is surface modification by dry mixing. In Example 1, each component is dry mixed, and in Example 2, all components are dry mixed in advance. This mixed powder is used for surface modification. Due to the difference in the procedure in this manufacturing method, it was found that powdered maltose (Sunmalt) was more uniformly dispersed by the manufacturing method of Example 2 than in Example 1, that is, by pre-mixing and surface modification. It is thought that the influence of the four types of turmeric powder and essential oil components of turmeric extract or fat-soluble components on tablet hardness by (Sunmalt) was reduced.

That is, for the effectiveness of extending the shelf life of turmeric-containing tablets, powdered maltose (Sunmalt) was used, and fine silica gel (Cyropage) and sucrose fatty acid ester (Sugar Ester) were added to modify the surface. It was found that this was effective.

In addition, regarding the friability of the turmeric-containing tablets of each comparative example, as shown in Table 4, after one month storage, comparative example A increased from about 0.1% to about 0.4%, whereas comparative example A -1, it remains at about 0.1% or less without increasing. In addition, in other comparative examples, similar to comparative example A-1, in comparative examples A-3 to A-7, in which fine silica gel (Silopage) and sucrose fatty acid ester (sugar ester) were added, a change over time test was conducted. Including preserved items, it remains at around 0.1%. Comparative Example A-2, in which fine silica gel (Silopage) and sucrose fatty acid ester (sugar ester) were not added, had a high concentration of 1.10% immediately after production. From these results, it was confirmed that the addition of fine silica gel (Silopage) and sucrose fatty acid ester (sugar ester) was effective in suppressing the friability of the tablets. Comparative Examples A-6 and A-7 in which powdered maltose (Sunmalt) was further added had a slightly higher value of 0.14% after one month of aging than Comparative Example A-6, but about 0.1% Regarding the following and the friability of tablets, great effects were seen when powdered maltose (Sunmalt) was used in combination with fine silica gel (Silopage) and sucrose fatty acid ester (Sugar Ester).

Furthermore, as shown in Table 6, the friability of Comparative Example B increased from about 0.4% to about 0.7%, whereas in Example 1 no significant change was observed. As for changes in friability over time, by adding powdered maltose (Sunmalt) and modifying the surface, although a decrease in friability can be seen after one week, there is no significant increase even after one month. It can be seen that the temperature can be kept low compared to immediately after manufacturing. Regarding the disintegration time, as shown in Table 7, it was confirmed that the tablets containing the oily component disintegrated relatively quickly in about 10 minutes. Furthermore, as shown in Table 8, the moisture content was maintained at about 2%. The disintegration time over time was as shown in Table 7 after one month, and the disintegration took about 10 minutes. Regarding moisture, the results after one month were as shown in Table 8, and no change was observed over time.

Furthermore, regarding curcumin, which is considered to be a typical active ingredient of turmeric, the physical property results of Example 2 of the present invention show that the content of curcumin after 3 months of aging was compared with the results immediately after tablet compression. No decrease was observed, and the amount was 2.1g/100g, that is, 6.93mg in one tablet (330mg).

In addition, curcuminoids were confirmed to have slightly decreased to 0.6% after 3 months, but from 3.12g/100g immediately after tableting, that is, 10.3mg in 1 tablet (330mg), to 3% after 3 months. The result was 10g/100g, that is, 10.23mg in one tablet (330mg), and no major change was observed for this curcuminoid.

Claims (4)

In a method for producing a tablet containing four types of turmeric, purple turmeric, autumn turmeric, tropical turmeric, spring turmeric, and turmeric extract,
100 parts of turmeric powder in which each of the four types of turmeric is mixed in the same ratio is charged into any of a stirring granulator, a fluidized bed granulator, or a rolling granulator and mixed uniformly, and the above-mentioned turmeric is uniformly mixed therein. Add 1 to 5 parts of turmeric extract and mix uniformly.
Here, 1 to 10 parts of a cellulose derivative aqueous solution is added to obtain surface-modified granules by wet coating,
After drying and sizing the granules to obtain sized granules,
To the sized granules, 1 to 10 parts of fine silica gel that has been previously sieved and deagglomerated, 1 to 10 parts of powdered maltose, and 1 to 5 parts of sucrose fatty acid ester that has been previously sieved and deagglomerated are added to the sized granules. Dry mixing in order to obtain a surface-modified mixed powder,
This mixed powder is made into tablets using a tablet machine.
A method for producing a turmeric-containing tablet, characterized by: In a method for producing a tablet containing four types of turmeric, purple turmeric, autumn turmeric, tropical turmeric, spring turmeric, and turmeric extract,
100 parts of turmeric powder in which each of the four types of turmeric is mixed in the same ratio is charged into any of a stirring granulator, a fluidized bed granulator, or a rolling granulator and mixed uniformly, and the above-mentioned turmeric is uniformly mixed therein. Add 1 to 5 parts of turmeric extract and mix uniformly.
Here, 1 to 10 parts of a cellulose derivative aqueous solution is added to obtain surface-modified granules by wet coating,
The granules are dried and sized to obtain sized granules, and
1 to 10 parts of fine silica gel that has been previously sieved and deagglomerated, 1 to 10 parts of powdered maltose, and 1 to 5 parts of sucrose fatty acid ester that has been previously sieved and deagglomerated are mixed in advance to form a mixed powder. Get,
Dry mixing the mixed powder with the sized granules to obtain a surface-modified mixed powder,
This surface-modified mixed powder is used to make tablets using a tablet machine.
A method for producing a turmeric-containing tablet, characterized by: In a method for producing a tablet containing four types of turmeric, purple turmeric, autumn turmeric, tropical turmeric, spring turmeric, and turmeric extract,
100 parts of turmeric powder in which each of the four types of turmeric is mixed in the same ratio is charged into any of a stirring granulator, a fluidized bed granulator, or a rolling granulator and mixed uniformly, and the above-mentioned turmeric is uniformly mixed therein. Add 1 to 5 parts of turmeric extract and mix uniformly.
Here, 1 to 10 parts of a cellulose derivative aqueous solution is added to obtain surface-modified granules by wet coating,
After drying and sizing the granules to obtain sized granules,
To the sized granules, 1 to 10 parts of fine silica gel that has been previously sieved and deagglomerated, 1 to 10 parts of powdered maltose, and 1 to 5 parts of sucrose fatty acid ester that has been previously sieved and deagglomerated are added to the sized granules. Dry mixing in order, further adding fine powder HPC, powdered cellulose, crystalline cellulose, and highly branched cyclic dextrin and dry mixing to obtain a surface-modified mixed powder,
This mixed powder is made into tablets using a tablet machine.
A method for producing a turmeric-containing tablet, characterized by: In a method for producing a tablet containing four types of turmeric, purple turmeric, autumn turmeric, tropical turmeric, spring turmeric, and turmeric extract,
100 parts of turmeric powder in which each of the four types of turmeric is mixed in the same ratio is charged into any of a stirring granulator, a fluidized bed granulator, or a rolling granulator and mixed uniformly, and the above-mentioned turmeric is uniformly mixed therein. Add 1 to 5 parts of turmeric extract and mix uniformly.
Here, 1 to 10 parts of a cellulose derivative aqueous solution is added to obtain surface-modified granules by wet coating,
The granules are dried and sized to obtain sized granules, and
1 to 10 parts of fine silica gel that has been previously sieved and deagglomerated, 1 to 10 parts of powdered maltose, and 1 to 5 parts of sucrose fatty acid ester that has been previously sieved and deagglomerated are mixed in advance to form a mixed powder. Get,
Dry mixing the mixed powder with the sized granules,
Furthermore, fine powder HPC, powdered cellulose, crystalline cellulose, and highly branched cyclic dextrin are added to obtain a surface-modified mixed powder,
This surface-modified mixed powder is used to make tablets using a tablet machine.
A method for producing a turmeric-containing tablet, characterized by: