JP7381799B1 - Method for producing tablets containing long life herb and turmeric - Google Patents

Abstract

[Problem] To provide a manufacturing method that makes use of essential oil components, which are useful components contained in turmeric, and fat-soluble components contained in Chomeisou, to obtain tablets containing these components, and to distribute them. To provide a method for producing a tablet containing long life herb and turmeric, which has a strength that does not easily lose its shape or break during use. [Solution] In a method for manufacturing tablets containing Chomeiso and four types of turmeric, purple turmeric, tropical turmeric, autumn turmeric, and spring turmeric, the blending ratio of Chomeiso powder and each of the four types of turmeric powder A first modification step in which the surface is modified by wet coating using an aqueous cellulose derivative solution, and each surface-modified powder is The second modification step includes dry mixing powdered maltose, fine silica gel, and sucrose fatty acid ester to modify the surface. [Selection diagram] None

Description

TECHNICAL FIELD The present invention relates to a method for producing tablets containing Chomeisou and turmeric. More specifically, the present invention relates to a method for producing tablets having physical properties that can withstand practical use of Chomeiso and Turmeric, which are difficult to compress.

Peucedanum japonicum is a wild plant of the Umbelliferae family that is called long-life grass in Okinawa and grows wild along the coast from southern Kyushu to the Okinawa region.
The leaves and stems of this long-life grass (Botanbofuu) contain β-carotene, lutein, chlorophyll, polyphenols, and vitamin C. Among these useful ingredients, chlorogenic acid as a polyphenol has been reported to have the ability to suppress postprandial blood sugar levels.

Turmeric (Curcuma longa L.) is a medicinal plant of the ginger family that is native to India and is cultivated in tropical and subtropical regions around the world, mainly in Southeast Asia. The rhizomes are mainly used. Turmeric rhizomes contain 3-5% curcumin (yellow pigment). Curcumin is considered to be a typical active ingredient of turmeric that contributes to antioxidant capacity, improvement of liver function, and maintenance of liver function, and various formulations and manufacturing methods shown below have been disclosed.

Patent Document 1 is a soft tablet containing turmeric extract, and is a preparation consisting of turmeric extract, a gelling agent such as gelatin, a plasticizer such as glycerin, a releasing agent such as lecithin, a sweetener, a preservative, and a flavoring agent. It is an orally administered drug that can continuously deliver active ingredients over a long period of time to affected areas, not only the esophagus and gastrointestinal tract.
Patent Document 2 discloses a jelly containing turmeric and curcumin, characterized in that the gelling agent constituting the jelly consists of gellan gum and carrageenan, and is a jelly with a composition that gradually releases curcumin in the stomach and intestines.
Regarding masking the unpleasant taste of preparations containing turmeric etc., Patent Document 3 found that the unpleasant taste and off-taste of turmeric extract was greatly improved by adding carbonic acid, and the unpleasant taste and off-taste were reduced. This paper proposed a technology for creating a beverage containing turmeric extract.

Patent Document 4 discloses that the unpleasantness of edible compositions caused by functional materials such as turmeric is caused by the use of 30 mass dextrin made from potatoes, with a DE (dextrose equivalent) of 2 or more and 6 or less, and prepared with distilled water at 25°C. % aqueous solution for 5 minutes at 25°C using dextrin having a viscosity of 150 Pa·s or less.
Patent Document 5 discloses a method for improving odor and taste by heating turmeric powder, in which the curcumin content in turmeric after heating is 80% of the curcumin content in turmeric before heating. This is the heating method described above. As for the heating treatment method, it is stated in Examples that the effect was confirmed at 155° C. for 15 minutes.

In addition, Non-Patent Document 1 reports on the molding of tablets using turmeric, and many turmeric-related grain (tablet) products have lower tablet hardness than that of general pharmaceuticals, and their compression moldability is is not good. Generally, granules for tabletting are said to be suitable for the fluidized bed granulation method, the rolling fluidized bed granulation method, and the agitation granulation method, in that order. Therefore, granulation was performed using a fluidized bed granulation device using collagen peptide, sodium alginate, and hydroxypropyl cellulose as binders. When granulated with hydroxypropyl cellulose, the hardness tends to be in the order of autumn turmeric < spring turmeric < purple turmeric depending on the type of turmeric. The results showed that the tablet hardness of each granule differs depending on the product, and that the reason for this is the lipid content in turmeric more than the physical properties of the powder. Then, the lipid content of the above three types of turmeric was measured. The results showed that autumn turmeric had lower lipid content than spring turmeric. Here, when various types of turmeric were defatted with diethyl ether and tablets were made using the defatted powder, the tablet hardness of autumn turmeric was improved by 16.5 times.

Furthermore, according to Non-Patent Document 2, Chomeiso contains a methylene chloride extract and an ethyl acetate soluble part, and these extracts and fractions are considered to be fat-soluble components, but in total about Contains 7%. These extracts and fractions are the above-mentioned useful components of Chomeiso, and based on these results, the amount of fat-soluble components per tablet (350 mg) is about 4 mg.

On the other hand, powdered maltose with low sweetness is used as a tableting excipient that is added to form tablets to obtain the formability and tabletability of the material. (registered trademark). According to Non-Patent Document 3, Sunmalt (Midori) (registered trademark) is a carbohydrate suitable for low-pressure tableting and cannot be used for materials with poor moldability. It is stated that it can be done. Also shown is the tablet hardness when various carbohydrates are compressed into tablets.

Regarding Sunmalt (registered trademark), Non-Patent Document 4 further states that Sunmalt (Midori) (registered trademark) is a tablet product containing functional oil materials such as DHA because of its high oil retention ability. It shows the relationship between tableting pressure and tablet hardness when DHA is blended with dextrin or Sunmalt (registered trademark), which is said to be extremely effective in manufacturing, and the tablets are compressed.

Furthermore, Patent Document 6 states that in a method for producing a live bacteria preparation, in order to increase the residual rate of beneficial intestinal bacteria during production, a saccharide powder composition containing 60% by mass or more of maltitol (maltose) is used. It has been shown that a solid preparation can be produced by using 30 to 95% by mass and mixing this with beneficial intestinal bacteria. Here, as Example 1, Sunmalt (registered trademark) is used as the candy flour.

Further, in Patent Document 7, it is described in the claims and examples that Sunmalt (registered trademark) is used as a free water decomposition preventing material in a method for manufacturing a rice molded product.

Special table 2016-535028 publication Japanese Patent Application Publication No. 2017-197465 Japanese Patent Application Publication No. 2015-065938 JP2015-128420A Japanese Patent Application Publication No. 2007-116945 Japanese Patent Application Publication No. 2016-193893 Japanese Patent Application Publication No. 02-060556

Yasuhiro Kamata, PHARM TECH JAPAN, vol. 28 No. 14 (2012) pp. 179-186 Yasue Kikusaki et al., Effect of Okinawan spice plants on inhibiting the growth of food-poisoning bacteria, Life Science Research Journal, Vol. 1 (2002), pp. 11-16 Hayashibara Co., Ltd. homepage, product introduction, Sunmalt (registered trademark), [searched on March 8, 2020], Internet [https://www.food.hayashibara.co.jp/product/sunmalt/] Food and Development, VOL. 48 NO. 8 (2013) pp. 72-73 Kamata et al., Development of tablet forming technology for turmeric, Okinawa Prefectural Industrial Technology Center Research Report No. 9 (2007)

However, since the above-mentioned technologies of Patent Documents 1 and 2 are semi-solid preparations using a gelling agent, special equipment is required for manufacturing, and the addition of preservatives and the like is required for storage. It has the disadvantage that it involves many steps, is complicated, and increases costs.
Further, Patent Document 3 describes a technology for masking the unpleasant taste of turmeric in beverages, and Patent Document 4 also lists tablets as a form, but in Examples, peptides are used as functional materials in the form of an aqueous solution to achieve a masking effect. It is evaluated. However, the masking effect of turmeric in tablet form has not been confirmed, and it cannot be said that it is easy to carry and ingest.
The method of Patent Document 5 requires special equipment such as an autoclave, and has the drawback of increasing the manufacturing process and manufacturing cost.

Furthermore, in Non-Patent Document 1, it is possible to improve the hardness of tablets, but in order to obtain that hardness, the turmeric powder is defatted, that is, the essential oil components contained in turmeric are removed. be. In other words, turmeric essential oil has pharmacological effects such as promoting bile secretion, promoting stomach health, sterilization, and antiseptic properties. This is undesirable as it cannot bring out the best in it. In Non-Patent Document 1, in a tablet containing autumn turmeric, for example, when the essential oil content of autumn turmeric is 1.3 mL/50 g, a tablet containing 95% autumn turmeric containing 330 mg of autumn turmeric has an essential oil content of 8.15 μL, Since the hardness of this tablet is as low as 2.7 kgf (see Non-Patent Document 5), in order to clarify the cause of this, we degreased autumn turmeric powder with diethyl ether and produced the defatted powder. A comparison of the tablet hardnesses shows that the defatted powder yields tablets with a tablet hardness 16.5 times higher than that of the autumn turmeric powder. However, defatting the autumn turmeric powder causes the functions of the autumn turmeric to disappear, which is undesirable. Furthermore, Non-Patent Document 1 does not report on the stability of tablets over time. For tablets containing fat-soluble components such as essential oil components, it is important to test and observe tablet hardness and friability over time, that is, stability tests and long-term storage tests.

Furthermore, in Patent Document 6, Patent Document 7, Non-Patent Document 3, and Non-Patent Document 4, there is no mention of the use of turmeric for tabletting, and in particular, in Non-Patent Document 3, there is no mention of the use of turmeric as a material with poor moldability. However, when making tablets containing a high content of turmeric or tablets containing Chomeisou, it is difficult to make tablets with high hardness and low friability with Sunmalt (registered trademark). I couldn't.

In each of the above Patent Documents 1 to 5 and Non-Patent Document 1, although there are examples of using turmeric powder, they do not make use of the essential oil components contained in turmeric, and also do not utilize the fat-soluble components derived from Chomeiso. There is no disclosure regarding the inclusion of these essential oil components, and no specific considerations have been made regarding the use of useful components contained in these essential oil components to obtain preparations such as tablets.

Therefore, in order to solve the above-mentioned problems, the present invention aims to solve the problem of turmeric, which is said to be difficult to compress and mold into tablets that can withstand practical use. The present invention provides a manufacturing method that makes it possible to obtain tablets containing these by making use of the useful ingredients such as fat-soluble ingredients contained in Chomeisou, and which does not easily lose its shape during distribution. The object of the present invention is to provide a method for producing tablets containing turmeric and long-term herb that are strong enough to prevent breakage.

Next, means for solving the above problem will be explained.
A method for producing a tablet containing Chomeisou and turmeric according to claim 1 of the present invention is a method for producing a tablet containing Chomeisou and four types of turmeric: purple turmeric, tropical turmeric, autumn turmeric, and spring turmeric. ,
The Chomeisou powder and each of the four types of turmeric powder are mixed at a blending ratio of 2 parts of Chomeisou: 4 parts of Purple Turmeric: 3 parts of Tropical Turmeric: 2 parts of Autumn Turmeric: 1 part of Spring Turmeric. ~50 parts and 100 parts of the four types of turmeric powder are charged into either a stirring granulator, a fluidized bed granulator, or a rolling granulator,
Next, a first modification step is performed in which 1 to 10 parts of an aqueous cellulose derivative solution is added to the granulation device to obtain surface-modified granules by wet coating.
After drying and sizing the granules to obtain sized granules,
To the sized granules, 1 to 10 parts of fine silica gel that has been previously sieved and deagglomerated, 5.0% by weight of powdered maltose, and 1 to 5 parts of sucrose fatty acid ester that has been previously sieved and deagglomerated, A second modification step is carried out by dry mixing each in turn to obtain a surface-modified mixed powder,
A feature of this method is that tablets are made from this mixed powder using a tablet press.

According to this method for manufacturing tablets containing Chomeiso and turmeric, powdered maltose (for example, Sunmalt (registered trademark)), fine silica gel, and sucrose are added to Chomeiso and each of the four types of turmeric powder as additives. Fatty acid esters and cellulose derivatives such as hydroxypropyl cellulose are blended in a specific composition.

After surface-modifying the surface of Chomeiso powder and four types of turmeric powder by wet coating using an aqueous hydroxypropyl cellulose solution, the dried and sized granules were mixed with fine silica gel, powdered maltose (Sunmalt (registered trademark)), By performing surface modification by dry mixing in the order of sucrose fatty acid ester, it is possible to obtain tablets containing excellent Chomeisou and turmeric and having tablet physical properties sufficient for practical use.

In addition, according to the method for producing tablets containing this Chomeiso and turmeric, each composition consists of four types of turmeric powder, Chomeiso powder, cellulose derivative (hydroxypropyl cellulose), fine silica gel, and sucrose fatty acid. The ester is preferably 100 parts: 5 to 50 parts: 1 to 10 parts: 1 to 10 parts: 1 to 5 parts, more preferably 100 parts: 10 to 30 parts: 1 to 8 parts: 1 to 5 Parts: 1 to 3 parts. As a result, the turmeric content has been increased compared to conventional products, and the product contains Chomeiso and turmeric, which has sufficient tablet hardness and low friability while also containing the respective essential oil components and fat-soluble components. You can get tablets that will.

A method for producing a tablet containing Chomeisou and turmeric according to claim 2 is a method for producing a tablet containing Chomeisou and four types of turmeric: purple turmeric, tropical turmeric, autumn turmeric, and spring turmeric.
The Chomeisou powder and each of the four types of turmeric powder are mixed at a blending ratio of 2 parts of Chomeisou: 4 parts of Purple Turmeric: 3 parts of Tropical Turmeric: 2 parts of Autumn Turmeric: 1 part of Spring Turmeric. ~50 parts and 100 parts of the four types of turmeric powder are charged into either a stirring granulator, a fluidized bed granulator, or a rolling granulator,
Next, a first modification step is performed in which 1 to 10 parts of an aqueous cellulose derivative solution is added to the granulation device to obtain surface-modified granules by wet coating.
The granules are dried and sized to obtain sized granules, and
5.0% by weight of powdered maltose, 1 to 10 parts of fine silica gel that has been previously sieved and deagglomerated, and 1 to 5 parts of sucrose fatty acid ester are mixed in advance to obtain a mixed powder,
performing a second modification step of dry mixing the mixed powder with the sized granules to obtain a surface-modified mixed powder;
A feature of this method is that tablets are made from this surface-modified mixed powder using a tablet press.

According to this method for manufacturing tablets containing Chomeiso and turmeric, powdered maltose (for example, Sunmalt (registered trademark)), fine silica gel, and sucrose are added to Chomeiso and each of the four types of turmeric powder as additives. Fatty acid esters and cellulose derivatives such as hydroxypropyl cellulose are blended in a specific composition.

After surface-modifying the surface of Chomeiso powder and four types of turmeric powder by wet coating using an aqueous hydroxypropyl cellulose solution, the dried and sized granules were mixed with fine silica gel, powdered maltose (Sunmalt (registered trademark)), The sucrose fatty acid ester is dry mixed, but powdered maltose (Sunmalt (registered trademark)), fine silica gel, and sucrose fatty acid ester are mixed in advance to obtain a mixed powder, and this pre-mixed mixed powder is mixed. Surface modification is performed by dry mixing the surface-modified Chomeiso and turmeric powder. By surface modification, it is possible to obtain tablets containing excellent longevity herb and turmeric and having tablet physical properties sufficient for practical use.

In addition, according to the method for producing tablets containing this Chomeiso and turmeric, each composition consists of four types of turmeric powder, Chomeiso powder, cellulose derivative (hydroxypropyl cellulose), fine silica gel, and sucrose fatty acid. The ester is preferably 100 parts: 5 to 50 parts: 1 to 10 parts: 1 to 10 parts: 1 to 5 parts, more preferably 100 parts: 10 to 30 parts: 1 to 8 parts: 1 to 5 Parts: 1 to 3 parts. As a result, the turmeric content has been increased compared to conventional products, and the product contains Chomeiso and turmeric, which has sufficient tablet hardness and low friability while also containing the respective essential oil components and fat-soluble components. You can get tablets that will.

The method for producing a tablet containing Chomei-so and turmeric according to claim 3 is the method for producing a tablet containing Chomei-so and turmeric according to claim 1 ,
During the dry mixing in the second reforming step,
The present invention is characterized in that a fine powder binder made of a cellulose derivative is added to the fine silica gel and the sucrose fatty acid ester.

According to this method for producing tablets containing Chomeisou and turmeric, in the second modification step, finely divided silica gel and sucrose fatty acid ester are added as a finely divided binder, such as a finely divided cellulose derivative, preferably finely divided hydroxypropyl. Add cellulose.

As a result, the surface modification is further improved, and it is possible to obtain tablets containing excellent long-term herb and turmeric and having tablet physical properties sufficient for practical use.

According to the method for producing a tablet containing long-life herb and turmeric according to claim 1 of the present invention, various useful effects of turmeric can be obtained together with essential oil components contained in turmeric, and long-lived tablets can be obtained. Various useful effects of grass can be obtained together with fat-soluble components contained in Chomeiso, and in the production method of the present invention, Chomeiso and turmeric as the main ingredients are wet-coated in advance using a granulation device. The surface of the granules is modified by adding powdered maltose, and the surface is modified by adding fine silica gel and sucrose fatty acid ester. By modifying them and mixing them in order, it is possible to obtain tablets with good moldability, that is, by preventing tableting failure when molding the tablets with a tablet machine.

In addition, even though the tablets that are molded into products contain essential oil components and fat-soluble components, they have sufficient hardness and will not be damaged during the distribution process. In other words, the static strength of the tablet is such that it can withstand direct force applied during the manufacturing process or when handled by the user. Furthermore, the degree of abrasion, which is an indicator of ease of tablet breakage due to dropping or abrasion, is extremely low, and unlike conventional products, a portion of the tablet surface does not chip or peel. In other words, the dynamic strength of the tablet is the strength to withstand external forces such as vibrations during transportation such as handling during the distribution process. The exudation of essential oil components and fat-soluble components inside the tablet causes a decrease in the binding force between powder particles, resulting in a decrease in tablet hardness and an increase in friability. Tablets containing this do not cause such problems. For these reasons, it becomes possible to obtain tablets containing excellent long-term herb and turmeric and having tablet physical properties that are sufficient for practical use.

Furthermore, according to this method for producing tablets containing Chomeisou and turmeric, the composition ratio is such that the useful effects of turmeric are sufficiently contained together with the essential oil components, and the useful effects of Chomeisou are also fully contained. It is possible to obtain tablets containing fat-soluble ingredients, etc., and also has sufficient tablet hardness, low friability, and sufficient practicality such as ease of distribution as tablets. Tablets containing the following can be obtained.

According to the method for producing a tablet containing long-life herb and turmeric according to claim 2 of the present invention, various useful effects of turmeric can be obtained together with the essential oil components contained in turmeric, and long-lived tablets can be obtained. Various useful effects of grass can be obtained together with fat-soluble components contained in Chomeiso, and in the production method of the present invention, Chomeiso and turmeric as the main ingredients are wet-coated in advance using a granulation device. The surface has been modified by the method, and granules can be obtained more easily.The granules are dried and sized to obtain sized granules, and powdered maltose, fine silica gel, and sucrose fatty acid ester are mixed in advance. By dry-mixing the sized granules and this mixed powder, the surface is modified by being more uniformly dispersed than by mixing each of them and surface-modified. It is possible to reduce the influence of the ingredients and fat-soluble components of Chomeisou on tablet hardness.

In addition, even though the tablets that are molded into products contain essential oil components and fat-soluble components, they have sufficient hardness and will not be damaged during the distribution process. In other words, the static strength of the tablet is such that it can withstand direct force applied during the manufacturing process or when handled by the user. Furthermore, the degree of abrasion, which is an indicator of ease of tablet breakage due to dropping or abrasion, is extremely low, and unlike conventional products, a portion of the tablet surface does not chip or peel. In other words, the dynamic strength of the tablet is the strength to withstand external forces such as vibrations during transportation such as handling during the distribution process. The exudation of essential oil components and fat-soluble components inside the tablet causes a decrease in the binding force between powder particles, resulting in a decrease in tablet hardness and an increase in friability. Tablets containing this do not cause such problems. For these reasons, it becomes possible to obtain tablets containing excellent long-term herb and turmeric and having tablet physical properties that are sufficient for practical use.

Furthermore, according to this method for producing tablets containing Chomeisou and turmeric, the composition ratio is such that the useful effects of turmeric are sufficiently contained together with the essential oil components, and the useful effects of Chomeisou are also fully contained. It is possible to obtain tablets containing fat-soluble ingredients, etc., and also has sufficient tablet hardness, low friability, and sufficient practicality such as ease of distribution as tablets. Tablets containing the following can be obtained.

According to the method for producing a tablet containing Chomei herb and turmeric according to claim 3 of the present invention, the tablet hardness is further increased by including the step of further adding a fine powder binder. A tablet containing the following can be obtained.

The tablet containing Chomeisou and turmeric of the present invention is a tablet containing powder of Chomeisou and powders of four types of turmeric, purple turmeric, tropical turmeric, autumn turmeric, and spring turmeric. Powdered maltose, fine silica gel, sucrose fatty acid ester, and cellulose derivatives are used as surface modifiers in a specific composition together with each component such as essential oil components contained in the method. Here, the cellulose derivative is an aqueous solution, Using this cellulose derivative aqueous solution, the surface is modified by wet coating to form granules, and the granules are further surface modified by dry mixing powdered maltose, fine silica gel, and sucrose fatty acid ester. It is obtained by a manufacturing method that is compressed into tablets.
In this manufacturing process, the cellulose derivative is preferably hydroxypropylcellulose, and the powdered maltose is preferably Sunmalt (registered trademark: Hayashibara Co., Ltd.), which has sufficient hardness and friability as a tablet for practical use. Tablets containing Uruchomeisou and turmeric can be obtained.

Furthermore, in surface modification by dry mixing, a fine binder may be added to the fine silica gel and the sucrose fatty acid ester. ), and Cerny (registered trademark) SSL-SFP (trade name: Nippon Soda Co., Ltd.) or the like can be suitably used.

The characteristics of the long life grass and turmeric in the present invention are as follows.
The chomeiso used in the present invention is a type of perennial herb of the Umbelliferae family that grows wild along the coast in warm regions such as Okinawa Prefecture. It is an ingredient that has been useful for health as a folk medicine. Recent research has revealed that it has a high antioxidant effect and is effective in promoting urination and improving blood flow.
The leaves and stems of Chomeiso are rich in polyphenols such as vitamin A, vitamin B ₂ , vitamin C, vitamin E, β-carotene, calcium, isosamidine, rutin, chlorophyll, and chlorogenic acid. Among these useful ingredients, chlorogenic acid as a polyphenol has been reported to have the ability to suppress postprandial blood sugar levels, and is sometimes used in folk medicine to treat colds, asthma, kidney disease, and neuralgia. It contains many useful ingredients such as removing oxygen, beautifying the skin, promoting urination, and improving blood flow.

There are four types of turmeric used in the present invention: autumn turmeric, spring turmeric, purple turmeric, and tropical turmeric. In Chinese medicine, it is used as a choleretic, stomachic, diuretic, hemostatic, and menstrual medicine.
Autumn turmeric contains essential oil components and curcumin. Curcumin's effects can be expected to strengthen liver function, promote digestion, and increase appetite.
Spring turmeric has dietary fiber, minerals, and essential oils that provide moderate stimulation to the intestines, which improves stomach health.
Purple turmeric, also known as gajutsu, is aromatic, has a bitter taste, and is used as an aromatic gastrointestinal because it stimulates the digestive system.
Tropical turmeric has a high content of essential oil components and curcumin.

According to the comparison of cultivation and measurement results by the applicant, the essential oil components are 1.3 mL/50 g for autumn turmeric harvested in 2021 and 2022, and 2.8 to 3.4 mL/50 g for tropical turmeric. The essential oil content was about 2 to 3 times that of autumn turmeric.
In addition, in a comparison of total curcuminoids including curcumin, autumn turmeric harvested in 2021 and 2022 was 0.461-0.612%, and tropical turmeric was 5.5-5.8%, compared to autumn turmeric. Tropical turmeric obtained approximately 9 to 10 times more results. Therefore, tropical turmeric can be expected to have high effects due to curcumin, such as antioxidant capacity, improvement of liver function, and maintenance of liver function.
For reference, the total curcuminoids of spring turmeric and purple turmeric were 0.08 to 0.233% and 0 to 0.0007%.

The turmeric extract contained in turmeric, for example, the ethanol extract of autumn turmeric contains 95% curcuminoids. By incorporating this turmeric extract into tablets, one can expect the high effects of curcumin. This curcumin has hepatoprotective action, antioxidant action, antitumor action, immunostimulatory action, anti-inflammatory action, and antibacterial action.
Curcumin is sparingly soluble in water, is light-resistant and sensitive to ultraviolet rays, and darkens in the presence of trace amounts of metals, especially iron ions. Moreover, an alcohol or diethyl ether solution exhibits a bright yellow color. Note that curcuminoids are also poorly soluble in water and are ethanol-soluble compounds.
Curcuminoids are a type of polyphenol and are mainly classified into three types: curcumin, demethoxycurcumin, and bisdemethoxycurcumin.

The cellulose derivatives used as binders for the tablets containing Chomeisou and turmeric of the present invention include hydroxypropylcellulose (HPC), methylcellulose (MC), carboxymethylcellulose (CMC/carmellose sodium), hydroxypropylmethylcellulose ( HPMC, hypromellose), etc.

In addition, the fine silica gel constituting the additive includes fine silicon dioxide, fine powder silica (Silopage (registered trademark: Fuji Silysia Chemical Co., Ltd.), light anhydrous silicic acid (Aerosil 200 (registered trademark: Nippon Aerosil Co., Ltd.), Examples include Ad Solider 101 (registered trademark: Freund Sangyo Co., Ltd.).

Furthermore, as the sucrose fatty acid ester constituting the additive, sucrose stearate (S-370, S-370F, S-1170, S-1170F (product name: Mitsubishi Chemical Corporation)), sucrose behenic acid Ester (B-370, B-370F (product name: Mitsubishi Chemical Corporation)), sucrose mixed fatty acid ester (POS-135 (product name: Mitsubishi Chemical Corporation)), etc. are used.

Furthermore, in the tablet containing the long life herb and turmeric of this embodiment, stabilizers, flavoring agents, sweeteners, etc. can be added in addition to these.

The tablet containing the long life herb and turmeric of the present invention thus configured can be applied not only to the health food field but also to the fields of foods, pharmaceuticals, quasi-drugs, and the like. Further, as for the dosage form, tablets are most preferable, but capsules, granules, fine granules, powders, etc. can also be used.

The tablet containing the longevity herb and turmeric of the present invention configured in this way is a tablet containing four types of turmeric, autumn turmeric, spring turmeric, purple turmeric, and tropical turmeric, and as described above, each turmeric has its own book. The essential oil content of turmeric harvested by the applicant in 2021 and 2022 in-house cultivation is 1.3 mL/50 g for autumn turmeric, 0.8-1.1 mL/50 g for spring turmeric, and 0.5-0.7 mL for purple turmeric. /50g, and 2.8-3.4mL/50g for tropical turmeric. The essential oil content of tropical turmeric was approximately 2 to 3 times that of autumn turmeric. Based on this result, the essential oil content per tablet (350 mg) is calculated to be 8.3 μL. The turmeric extract that can be added to the four types of turmeric is an ethanol extract of autumn turmeric, which is 95% curcuminoid, and 5% is thought to be fat-soluble components such as fats and oils and fatty acids. The fat-soluble component derived from turmeric extract is 0.3 mg per tablet.

In the tablets containing Chomeisou and turmeric of the present invention, in addition to the fat-soluble components derived from Chomeisou, the tablets contain essential oil components of four types of turmeric, and the shape of the tablet is ensured by the fat-soluble ingredients. Although it was difficult to manufacture tablets with high hardness, the manufacturing method of the present invention made it possible to manufacture tablets with high hardness of 8 kgf or more.

The tablets containing Chomeisou and turmeric of the present invention, which have such high tablet hardness, are conventional commercially available products such as Chomeisou (Botanbofuu) tablets (Shimanodaichi) (product name: Co., Ltd. Daikichi) (https://shimanodaichi.info/item/8204/) has a tablet hardness of 3.44 kgf, and Chomeisou tablets (product name: Yuta Herb Garden) (https://cyouju.com/product/41/) The tablet hardness is 3.55 kgf, and the tablet hardness of Triple Turmeric EX Plus (product name: transcosmos Inc.) (https://www.666-666.jp/251301.html) is 3.98 kgf, both of which are used as pharmaceuticals. Tablets have a standard hardness of 5 kgf or less, and compared to these, the tablets of the present invention have sufficient hardness and do not suffer from breakage during distribution.

Therefore, the tablet containing Chomeisou and turmeric of the present invention can obtain the various useful effects of turmeric together with the essential oil components contained in turmeric, and can also obtain the useful effects of Chomeisou with the fat-soluble components. The surface is modified by adding powdered maltose, and the surface is further modified by adding fine silica gel and sucrose fatty acid ester to improve moldability. It can prevent tableting failure when forming tablets, and has sufficient hardness even when the formed tablets contain essential oil components. The degree of abrasion, which is an indicator of the ease with which tablets are broken due to dropping or abrasion, can be extremely small to 0.5% or less. It becomes possible to produce tablets containing excellent long-term herb and turmeric without missing parts or peeling, and having tablet physical properties that can withstand practical use.

Furthermore, although the tablet containing the long life herb and turmeric of the present invention contains essential oil components and fat-soluble components, it is constructed with sufficient hardness so that it does not break easily as described above. There is no wear and tear. For this reason, conventional tablets containing turmeric were degreased to obtain hardness as shown in Non-Patent Document 1, but the tablets containing turmeric and long-term herb of the present invention have a useful The tablets contain these useful ingredients without removing essential oil components and fat-soluble components, and the pharmacological effects of essential oil components such as bile secretion promotion, stomach health, sterilization, and antiseptic properties. It can be ingested as turmeric powder, which has various functions such as fat-soluble components and polyphenols. There is nothing to do.

In addition, in the tablet containing Chomeisou and turmeric of the present invention, due to the porous nature of Sunmalt (registered trademark) as powdered maltose blended as an additive, essential oil components such as curcumin and fat-soluble components of Chomeisou can be absorbed. It has the effect of obtaining stability in the content state, thereby obtaining stability over time, and making it possible to suppress changes over time as a tablet, that is, the possibility of a decrease in hardness or an increase in friability over time.
Furthermore, surface modification by adding fine silica gel and sucrose fatty acid ester in addition to powdered maltose improves the formability into tablets and avoids tableting problems.

Next, a method for manufacturing a tablet containing the above-mentioned long-term herb and turmeric will be explained.
First, the powder of Chomeisou and the powder of each of the four types of turmeric, purple turmeric, tropical turmeric, autumn turmeric, and spring turmeric, are uniformly mixed using a stirring granulation device. The four types of turmeric have different yields when cultivated, and the distribution of the amount of each turmeric is changed in order to keep the amount of all four types at a predetermined amount, and the distribution amount described later is the value of the preferred combination. However, other combinations may be changed as appropriate, such as depending on the amount of essential oil components contained. Further, in addition to the stirring granulator, a fluidized bed granulator or a rolling granulator may be used.

Next, as a first modification step, the above mixed powder is wet-coated with a solution of a cellulose derivative dissolved in water in advance. The cellulose derivative is hydroxypropyl cellulose.

Next, the granules whose surface has been modified by this wet coating are dried using a dryer.

Next, the dried granules are sized using a sizing machine to obtain sized granules.

Next, as a second modification step, pre-sieved powdered maltose, fine silica gel, and sucrose fatty acid ester are added to the sized granules, and the surface is modified by dry mixing.
Here, fine powder of a finely divided cellulose derivative, such as hydroxypropyl cellulose (HPC), may be further added to the finely divided silica gel and sucrose fatty acid ester as a finely divided binder, and the surface may be modified by dry mixing.

Next, tablets are made from the surface-modified granules using a tablet press.

Here, Chomeiso and Turmeric are powdered while containing useful components such as essential oil components, fat-soluble components, oil and fat components, and polyphenols, and the blending ratio of each powder is Choumeiso 2: Purple Turmeric 4: Tropical turmeric 3: Autumn turmeric 2: Spring turmeric 1.
The blending ratio of each composition is 100 parts of four types of turmeric powder, 5 to 50 parts of Chomeiso powder, 1 to 10 parts of cellulose derivative, 1 to 10 parts of fine silica gel, and 1 to 5 parts of sucrose fatty acid ester. do. Preferably, the following ingredients are used: 100 parts of four types of turmeric powder: 10 to 30 parts of Chomeiso powder: 1 to 8 parts of cellulose derivative: 1 to 5 parts of fine silica gel: 1 to 3 parts of sucrose fatty acid ester.
As a result, the content of the four types of turmeric is increased compared to the conventional formulation ratio, and while containing Chomeisou, each essential oil component and oil and fat component are contained without being defatted, and the tablet has sufficient hardness and low Tablets containing Chomei herb and turmeric with friability can be obtained.

According to the method for producing turmeric-containing tablets of the present invention, after surface-modifying the surface of Chomeiso powder and turmeric powder with a cellulose derivative aqueous solution, which is a water-soluble polymer solution, by a wet coating method, the surface-modified granules are obtained by surface-modifying the powder. Furthermore, the surface of the granules containing Chomeiso and turmeric was modified by a dry mixing method using fine silica gel and sucrose fatty acid ester, respectively.
Regarding this surface modification, in ``Application of surface modification method to standard formulations'' by Kato et al. An example is shown in which surface modification is carried out by mixing all at once with light silicic anhydride, but in the production method of the present invention, the surface of Chomei herb and turmeric as the main ingredients is preliminarily modified by a wet coating method. The granules were then surface-modified using powdered maltose, fine silica gel, and sucrose fatty acid ester individually by a dry mixing method, and the optimal mixing ratio of powdered maltose, fine silica gel, and sucrose fatty acid ester was determined. By identifying this, we were able to obtain tablets containing Chomeisou and turmeric with sufficient hardness and low friability while containing essential oil components and fat-soluble components.

In addition, various ingredients can be blended into the tablet containing the long life herb and turmeric of the present invention depending on the intended use.
For example, functional materials include turmeric extracts such as curcumin, demethoxycurcumin, and bisdemethoxycurcumin, evening primrose, chrysanthemum flowers, soybean isoflavones, agarisk, saw palmetto, yam leaves, red malt, docosahexaenoic acid, resveratrol, lactoferrin, Contains ingredients such as salacia, glucosamine, polyphenols, collagen, peptides, coenzyme Q10, kale, amino acids, ginkgo biloba, reishi, vitamins, minerals, GABA, astaxanthin, propolis, royal jelly, spirulina, and chlorella. good.

In the pharmaceutical field, antihistamines such as chlorpheniramine maleate, diphenhydramine hydrochloride, and promethazine; antitussive expectorants such as dextromethorphan hydrobromide, guaifenesin, and theophylline; antihypertensive agents such as captryl, methyldopa, and labetalol hydrochloride; Antiarrhythmic agents such as pindolol, propranolol hydrochloride, and procainamide hydrochloride; diuretics such as isosorbide and furosemide; antispasmodics such as scopolamine hydrobromide and papaverine hydrochloride; stomachic digestive agents such as roto extract, diastase, and cinnamon bark oil; Intestinal regulating agents such as berberine, lactic acid bacteria, and bifidobacteria; antacids such as magnesium oxide, magnesium carbonate, and sucralfate; _H2 receptor blockers such as cimetidine, ranitidine, and famotidine; antipyretic, analgesic, and antiinflammatory agents such as acetaminophen, ibuprofen, and ethenzamide. Medicinal ingredients may include drugs, hypnotic sedatives such as diazepam, nitrazepam, and phenobarbital sodium, and antidepressants such as amphetamine and imipramine.

Furthermore, nourishing and tonic health medicines include naturally derived substances such as herbal medicines and Chinese herbal medicines, proteins, amino acids, and minerals such as iron, calcium, and magnesium. Vitamins such as vitamin A, vitamin B ₁ , vitamin B ₂ , vitamin B ₆ , vitamin B ₁₂ , vitamin C, and vitamin E may also be included.

Next, specific examples of the above-described embodiments will be described together with comparative examples.
<Comparative example A>
First, as a comparison with tablets containing Chomei herb and turmeric of the present invention, comparative tablets containing Chomei grass without powdered maltose and four types of turmeric powder were prepared.
Table 1 shows the blending amount for each tablet physical property.

As comparative tablets, three examples A-1 to A-3 were combined in different amounts. The main ingredients of these tablets were Chomeiso and four types of turmeric powder, which were combined in a total amount of 94% by weight, and the four types of turmeric were combined in equal amounts.
Comparative Example A-1 contains 22.25% by weight of each of the four types of turmeric powder and 5.0% by weight of Chomeiso powder, and Comparative Example A-2 contains 21.00% by weight of each of the four types of turmeric powder. %, the Chomeisou powder is 10.0% by weight, and for Comparative Example A-3, the four types of turmeric powder are each 18.80% by weight, and the Chomeisou powder is 18.80% by weight.
In addition to the combination of these three types, a composition containing 3.0% by weight of hydroxypropylcellulose, 2.0% by weight of fine silica gel, and 1.0% by weight of sucrose fat fatty acid ester as cellulose derivatives was made.

The procedure for manufacturing this comparative tablet is as follows: First, four types of turmeric powder are blended with Chomeisou powder, the mixture is charged into an agitating granulator, an aqueous hydroxypropyl cellulose solution is added thereto, and the mixture is wet-coated to form granules.
Next, the granules are dried and sized.
Next, the sized granules were placed in a plastic bag, to which fine silica gel, which had been sieved in advance through a 20-mesh sieve, was added, and after dry mixing, sucrose fatty acid ester which had been sieved in advance through a 30-mesh sieve was added thereto. and dry mix in a plastic bag.
Next, this mixed powder was compressed into tablets using a rotary tablet machine at a rotation speed of 30 rpm, each tablet weighing 350 mg, and having a dosage form of 9 mmφAR.
The above-mentioned fine silica gel is silicon dioxide, such as Silopage (registered trademark: Fuji Cereal Chemical Co., Ltd.), and the sucrose fatty acid ester is, for example, Sugar Ester B-370F (trade name: Mitsubishi Chemical Corporation). use

<Example>
Next, as examples of tablets containing the long life herb and turmeric of the present invention, three examples will be prepared by changing the blending amounts of each component.
Table 2 shows the blending amount for each tablet physical property.

(Example 1)
First, as Example 1, 15.7% by weight of Chomeiso powder, 78.3% by weight of four types of turmeric powder, 3.0% by weight of hydroxypropylcellulose as a cellulose derivative, and 5.0% by weight of Sunmalt (registered trademark) as powdered maltose. % by weight, 2.0% by weight of fine silica gel, and 1.0% by weight of sucrose fatty acid ester. Here, the respective powders of Chomeisou and the four types of turmeric are mixed in a ratio of 2 parts of Chomeisou: 4 parts of purple turmeric: 3 parts of tropical turmeric: 2 parts of autumn turmeric: 1 part of spring turmeric. That is, the powder contains 15.7% by weight of Chomeisou powder, 31.3% by weight of purple turmeric, 23.5% by weight of tropical turmeric, 15.7% by weight of autumn turmeric, and 7.8% by weight of spring turmeric.

As a procedure for manufacturing the tablets of Example 1, first, the Chomeisou powder and the four types of turmeric powder were put into a stirring granulator.
Next, as a first modification step, an aqueous hydroxypropyl cellulose solution as an aqueous cellulose derivative solution is added thereto, wet-coated to form granules, and the granules are dried at 60° C. to a water content of 3% or less. That is, surface modification of Chomeisou powder and four types of turmeric powder is performed.
Next, the dried granules are sized using a Cormill (1.14 mm diameter screen, round impeller) to obtain sized granules.

Next, as a second modification step, the sized granules are placed in a plastic bag, and fine silica gel, which has been previously sieved through a 20-mesh screen, is added thereto, and dry mixing is performed.
Next, powdered maltose is added and dry-mixed, and then sucrose fatty acid ester, which has been previously sieved through a 30-mesh screen, is added and dry-mixed in a plastic bag. That is, the surfaces of the Chomeisou powder and the four types of turmeric powder are further modified.
Next, this mixed powder is compressed into tablets using a rotary tablet machine, each tablet weighing 350 mg, the dosage form being 9 mmφAR, and the rotation speed being 30 rpm.

The above-mentioned fine silica gel is silicon dioxide and Silopage (registered trademark: Fuji Cereal Chemical Co., Ltd.) is used, and the powdered maltose is Sunmalt (registered trademark: Hayashibara Co., Ltd.), and sucrose fatty acid ester is used. Sugar Ester B-370F (trade name: Mitsubishi Chemical Corporation) is used.

(Example 2)
Next, Example 2 has the same formulation and the same process as Example 1, but in Example 1, the three components of fine silica gel, powdered maltose, and sucrose fatty acid ester were dry mixed for each component. However, in this Example 2, there is a step of pre-mixing these three components (fine silica gel, powdered maltose, sucrose fatty acid ester), that is, obtaining a mixed powder, and this mixed powder is After wet coating in the first modification step, the mixture was added to the sized granules, and dry mixing was performed in the second modification step.

(Example 3)
Next, Example 3 is the same process as Example 1 above, but the amount of cellulose derivative (hydroxypropyl cellulose) used in the first modification step is 1.5% by weight, and the second modification step is as follows: The procedure involved dry mixing each component, and the amount of fine HPC added was 2.5% by weight.
In addition, each compounding amount of each of the above-mentioned Examples does not limit the present invention.

<Comparative example using the formulation example of the above example>
Next, an example will be shown as Comparative Example B in which the amounts of Chomei herb and turmeric were the same as in each of the above-mentioned Examples, and some surface modification was omitted.
(Comparative example B)
Comparative Example B includes 15.7% by weight of Chomeiso powder, 78.3% by weight of 4 types of turmeric powder, 3.0% by weight of hydroxypropylcellulose as a cellulose derivative, and 5.0% by weight of Sunmalt (registered trademark) as powdered maltose. The composition is as follows. Here, the powders of Chomeisou and the four types of turmeric are the same as above, and the blending ratio of each is 2 parts of Chomeisou: 4 parts of purple turmeric: 3 parts of tropical turmeric: 2 parts of autumn turmeric: 1 part of spring turmeric.

As a procedure for manufacturing the tablets of Comparative Example B, first, the Chomeisou powder and the four types of turmeric powder are put into a stirring granulator. Next, an aqueous solution of hydroxypropyl cellulose as an aqueous cellulose derivative solution is added to this powder, wet-coated to form granules, and the granules are dried at 60° C. to a water content of 3% or less and surface modified.
Next, the dried granules are sized using a Cormill (1.14 mm diameter screen, round impeller) to obtain sized granules.

Next, the sized granules are put into a plastic bag, powdered maltose (Sunmalt: registered trademark) is added thereto, dry mixed in the plastic bag to form a mixed powder, and this mixed powder is passed through a rotary tablet machine. Using the tablet, each tablet weighed 350 mg, the dosage form was 9 mmφAR, and the number of revolutions was 30 rpm to produce tablets.

That is, this comparative example B does not use the fine silica gel and sucrose fatty acid ester that are mixed with powdered maltose (Sunmalt: registered trademark) in the second modification step in the above example, but uses only powdered maltose (Sunmalt: registered trademark). It is a tablet with
Regarding the tableting properties of Sunmalt (registered trademark), it is stated in Non-Patent Document 3 that it can be used for tableting materials with poor moldability. This was designated as Comparative Example B.

<Evaluation of comparative examples and examples>
The hardness and friability of the tablets of Comparative Examples A-1 to A-3 were measured immediately after manufacture (see Table 1).
Furthermore, tablet hardness and friability of the tablets of Examples 1 to 3 and Comparative Example B were measured.
Tablet hardness was evaluated using a tablet hardness meter SmartTest50ST-50 (manufactured by Freund Sangyo Co., Ltd.) as an average value of 20 tablets.
Friability was measured using a tablet friability tester (manufactured by Toyama Sangyo Co., Ltd.: TFT-120) at 25 rpm for 15 minutes (sample mass: 10 g).
The disintegration time was evaluated using a tablet disintegration tester NT-610 (manufactured by Toyama Sangyo Co., Ltd.) using water as the test liquid, using 6 tablets.
Tablet moisture was measured and evaluated at 60° C. for 20 minutes (sample weight 10 g) using an infrared moisture meter (manufactured by Kett Scientific Research Institute, Inc.: FD-600-2).

From each test result, in Comparative Examples A-1 to A-3, the tablet hardness of Comparative Example A-1 with a low content of Chomeisou powder was high (7.22 kgf), and the tablet hardness of Comparative Example A-2 and Comparative Example A-3 was long. The grass powder content was 10.0%, 18.8%, and the tablet hardness was about 6 kgf.
From this, it seems that when the content of long-life grass powder is 10% or more, there is an influence on the tablet hardness, that is, a decrease in hardness.

Further, in the Examples, the tablet hardness in Example 2 was 8.33 kgf, and the tablet hardness in Comparative Example B was 3.45 kgf.
Example 2 exhibited a tablet hardness that was approximately twice as high as that of Comparative Example B.

From this result, Example 1 and Example 2 have the same formulation, but in the second modification step, surface modification by dry mixing of the granules was carried out for each component of fine silica gel, powdered maltose, and sucrose fatty acid ester. It can be seen that the tablet hardness results vary greatly depending on whether the test is carried out beforehand or after the three components have been mixed in advance to form a mixed powder.
By pre-mixing all the components of fine silica gel, powdered maltose, and sucrose fatty acid ester, the powdered maltose is sufficiently dispersed, and the essential oil components of turmeric and the fat-soluble components of Chomeiso are effectively absorbed from the granules. It is thought that this restrained the output.

<Time-dependent change test results of Examples and Comparative Example B>
Next, the tablet hardness, friability, disintegration time, and tablet moisture changes over time of each tablet of each of the above-mentioned Examples and Comparative Example B were compared. The results of each test are shown in Tables 3 to 6.

The tablets of Examples 1 to 3 and Comparative Example B were each placed in an aluminum bag, heat-sealed, and stored at 40° C. and 75 RH%.
Tablets that had been sealed and stored were opened and taken out after one week, and tablets that were opened and taken out after one month, and their tablet hardness and friability were measured. The results of each measurement are shown in Table 3. After taking out the tablets, the aluminum bag was heat-sealed for restorage.

From these test results, as shown in Tables 3 and 4, in Comparative Example B, Example 1, and Example 2, there was a tendency for tablet hardness to decrease and friability to increase over time.
This is thought to be due to the fat-soluble components contained in Chomeiso and the essential oils of turmeric leaching out over time.
Specifically, after storage for one week, the tablet hardness in Comparative Example B decreased by approximately 20% from the initial level, while in Example 1 and Example 2, the hardness decreased by approximately 10%, which is 1/2 of that in Comparative Example B. The decline remains at around 1%.
After one month of storage, the tablet hardness in Example 1 decreased by about 5% (4.96%) from the time of the start of the test. In addition, in Example 2, the tablet hardness was about 10% (10.7%) from the start of the test, and the tablet hardness decreased by about 10% from the start in one week, but after one month, In this case, a decrease of about 5 to 10% and no further decrease in tablet hardness over time was observed.

Therefore, in Examples 1 and 2, although a decrease in tablet hardness of about 10% is observed after one week of storage, the decrease in tablet hardness is approximately 5 to 10% after one month of storage. Therefore, it is considered that the influence of the essential oil components of turmeric and the fat-soluble components of Chomeisou on tablet hardness can be suppressed.
In Comparative Example B, the tablet hardness after one month from the start of the test was a little over 10% (13.3%).

Furthermore, regarding the degree of friability, Comparative Example B increased by about 0.3% after storage for one month, whereas Example 1 and Example 2 showed an increase of about 0.1%. Regarding this increase in friability over time, in each example, compared to Comparative Example B, powdered maltose (Sunmalt: registered trademark), fine granular silica gel (Silopage: registered trademark) and sucrose fatty acid ester (sugar ester: It can be seen that by adding the product name (trade name) and modifying the surface, it is possible to keep it low.
Regarding Example 3, a decrease of 0.02% was observed after storage for one week, but an increase of 0.01% after storage for one month, and no significant change was observed over time.

Regarding the disintegration time, as shown in Table 5, in the progress test after one month, although Comparative Example B was slightly shorter, each of Examples 1 to 3 disintegrated in about 15 minutes. In each example, it is thought that the reason was that the surface was modified by adding fine silica gel and sucrose fatty acid ester.
In other words, after producing a tablet, it maintains its shape and hardness, and its disintegration remains unchanged between immediately after production and one month later, and in addition to the hardness and friability mentioned above, it maintains its shape and appearance, which is the role of a tablet. It is possible to maintain ease of administration and disintegration during administration, and it is considered that quality can be controlled.

Furthermore, as shown in Table 6, the tablet moisture content remained at about 2% even after one month, and no change was observed over time. That is, it can be seen that the tablets immediately after production and one month later are stable without causing a decrease in moisture content.

From the results of Examples 1 to 3, it was found that Example 3 had the highest tablet hardness and a favorable result, but due to the combination of simplification of the formulation and raw material cost, A combination like this is considered to be good. In addition, the four types of turmeric, purple turmeric, tropical turmeric, autumn turmeric, and spring turmeric, are combined at a blending ratio of 78.3% by weight, taking into consideration the yield from cultivation, and the total amount of turmeric is 78.3% by weight. By setting turmeric to 15.7% by weight, the powder containing these useful essential oil components and fat-soluble components can be added to a large amount of 94% by weight. The turmeric content is 1.7 times higher than that of purple turmeric (11.4% by weight, 45.5% by weight), and has sufficient hardness of 6.45 to 9.86 kgf. It was possible to obtain tablets with a low degree of abrasion of 0.04 to 0.09%.

Claims (3)

In a method for producing a tablet containing Chomeisou and four types of turmeric: purple turmeric, tropical turmeric, autumn turmeric, and spring turmeric,
The Chomeisou powder and each of the four types of turmeric powder are mixed at a blending ratio of 2 parts of Chomeisou: 4 parts of Purple Turmeric: 3 parts of Tropical Turmeric: 2 parts of Autumn Turmeric: 1 part of Spring Turmeric. ~50 parts and 100 parts of the four types of turmeric powder are charged into either a stirring granulator, a fluidized bed granulator, or a rolling granulator ,
Next, a first modification step is performed in which 1 to 10 parts of an aqueous cellulose derivative solution is added to the granulation device to obtain surface-modified granules by wet coating.
After drying and sizing the granules to obtain sized granules,
To the sized granules, 1 to 10 parts of fine silica gel that has been previously sieved and deagglomerated, 5.0% by weight of powdered maltose, and 1 to 5 parts of sucrose fatty acid ester that has been previously sieved and deagglomerated, A second modification step is carried out by dry mixing each in turn to obtain a surface-modified mixed powder ,
This mixed powder is made into tablets using a tablet machine.
A method for producing a tablet containing long life herb and turmeric, characterized by: In a method for producing a tablet containing Chomeisou and four types of turmeric: purple turmeric, tropical turmeric, autumn turmeric, and spring turmeric,
The Chomeisou powder and each of the four types of turmeric powder are mixed at a blending ratio of 2 parts of Chomeisou: 4 parts of Purple Turmeric: 3 parts of Tropical Turmeric: 2 parts of Autumn Turmeric: 1 part of Spring Turmeric. ~50 parts and 100 parts of the four types of turmeric powder are charged into either a stirring granulator, a fluidized bed granulator, or a rolling granulator ,
Next, a first modification step is performed in which 1 to 10 parts of an aqueous cellulose derivative solution is added to the granulation device to obtain surface-modified granules by wet coating.
The granules are dried and sized to obtain sized granules , and
5.0% by weight of powdered maltose, 1 to 10 parts of fine silica gel that has been previously sieved and deagglomerated, and 1 to 5 parts of sucrose fatty acid ester are mixed in advance to obtain a mixed powder ,
performing a second modification step of dry mixing the mixed powder with the sized granules to obtain a surface-modified mixed powder ;
This surface-modified mixed powder is used to make tablets using a tablet machine.
A method for producing a tablet containing long life herb and turmeric, characterized by: The method for producing a tablet containing Chomei herb and turmeric according to claim 1 ,
During the dry mixing in the second reforming step,
A method for producing a tablet containing Chomeisou and turmeric, which comprises adding a fine powder binder made of a cellulose derivative to the fine silica gel and the sucrose fatty acid ester.