JP2008247809A - Collagen tablet - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a collagen tablet easily ingesting collagen in an amount expectable of a physiological activity with a small number of tablets and having good texture without sticking of the collagen to teeth or the interior of the oral cavity even when chewing and ingesting the tablet in the oral cavity. <P>SOLUTION: The collagen tablet comprises a water-insoluble calcium salt (A) having ≤50 μm average particle diameter and/or slightly water-soluble polysaccharides (B) having ≤100 μm average particle diameter. The content of the collagen is 10-60 mass% and the hardness of the tablet is 5-13 kgf. Furthermore, the mass per tablet is 1,000-3,000 mg. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention relates to a collagen tablet, and in particular, relates to a collagen tablet having a good texture and excellent handleability.

  Collagen is a protein that is abundant in body skin, bones, tendons, blood vessels, and the like. And it has been reported so far that various physiological activity effects are brought about by external use or internal use. Non-Patent Document 1 below reports the skin quality improving action by collagen and the osteoporosis preventing effect.

  Thus, since collagen has various physiological activity effects, it has been attracting attention as a functional food material in recent years, and has been developed in the market as various forms of food such as tablets, capsules, beverages and granules.

  However, since collagen is a material having poor fluidity, sticking or the like is likely to occur during compression molding. Collagen is also a material having high moisturizing properties, and its viscosity tends to increase when added. For this reason, when water is added to collagen to prepare granules, the collagen tends to become lumpy, and uniform granules are difficult to prepare.

  For example, Patent Document 1 below discloses that a raw material powder mixture containing hardened fats and collagen that is solid at room temperature is directly tableted to prevent sticking during compression molding.

Patent Document 2 below discloses that collagen is mixed with a polymer base material impregnated with water, and then a hydrophilic solvent is added to prepare uniform granules.
Naoaki Tsuzuka and Yayoi Kanzono, Monthly Food Chemical September 2005, p29-33 JP 2001-288073 A JP 2006-096690 A

  Various physiological functions by collagen have been reported so far, but in order to obtain a sufficient physiological function, it is necessary to ingest a relatively large amount of collagen. For this reason, many collagen-containing supplements on the market have a daily intake standard of 0.1 to 10 g.

  Tablet-type supplements and granule-type supplements are often used as supplements because of their excellent portability and storage stability. However, in the case of small tablets and granules having a size of about 100 to 1,000 mg, it is necessary to consume a large amount of these in order to obtain the amount of collagen necessary for obtaining sufficient physiological function. , Swallowed with water. For this reason, these could not be said to be supplements in a form in which collagen can be easily ingested regardless of the location.

  Chewable tablets are chewable supplements that can be taken anywhere without water. However, when collagen is included in the mouth, it tends to cling to teeth, lips, oral cavity, etc., and the texture is very bad. For this reason, the conventional chewable type tablets reduce the collagen content in order to suppress the texture of collagen, increase the number of tablets to be taken, or increase the collagen content at the expense of the texture. Since the number of tablets to be consumed was reduced, it was not easy and delicious.

  Patent Documents 1 and 2 disclose preparations such as tablets and granules containing collagen. However, the above Patent Documents 1 and 2 are inventions related to a formulation technique that focuses on physical properties during processing of collagen, and any problems related to the texture of collagen that occur when molded into various dosage forms are disclosed. Absent.

  In addition, the preparations disclosed in Patent Documents 1 and 2 are preparations that are swallowed mainly with water, and are not easily ingested without questioning the location.

  Therefore, the object of the present invention is to easily take the amount of collagen that can be expected physiological activity with a small number of tablets, and even if chewed in the oral cavity, collagen does not adhere to the teeth or oral cavity, An object of the present invention is to provide a collagen tablet having a good texture.

  In order to achieve the above object, the collagen tablet of the present invention contains a water-insoluble calcium salt (A) having an average particle size of 50 μm or less and / or a poorly water-soluble polysaccharide (B) having an average particle size of 100 μm or less. The collagen content is 10 to 60% by mass, the tablet hardness is 5 to 13 kgf, and the mass per tablet is 1,000 to 3,000 mg.

  According to the collagen tablet of the present invention, since the mass per tablet is 1,000 to 3,000 mg and contains 10 to 60% by mass of collagen, the amount of collagen that can be expected to have physiological activity with a small number of tablets. Can be ingested easily. In addition, since it contains a water-insoluble calcium salt (A) having an average particle size of 50 μm or less and / or a poorly water-soluble polysaccharide (B) having an average particle size of 100 μm or less, collagen is produced by the action of these raw materials. It is difficult to adhere to the mouth and the mouth, and the texture is good. And since the hardness of a tablet is 5-13 kgf, since it is a hardness which can be easily chewed and does not involve difficulty in handling, it can be ingested without water, Anyone can easily take the tablet without taking apart the tablet while carrying it or taking it.

  In the collagen tablet of the present invention, the collagen is preferably a collagen peptide having an average molecular weight of 10,000 or less. According to this aspect, since the absorbability of collagen is improved, a more excellent physiological activity effect can be obtained.

  The collagen tablet of the present invention preferably has a collagen content of 200 to 1,800 mg per tablet. According to this aspect, the collagen necessary for obtaining the physiologically active effect can be ingested with a smaller number of tablets.

  The collagen tablet of the present invention preferably contains 10 to 60% by mass of the water-insoluble calcium salt (A) and the poorly water-soluble polysaccharide (B).

  In the collagen tablet of the present invention, the water-insoluble calcium salt (A) is preferably calcium carbonate and / or calcium phosphate.

  In the collagen tablet of the present invention, the poorly water-soluble polysaccharide (B) is preferably corn starch and / or rice starch.

  According to each said aspect, when it eats, adhesion of the collagen to an intraoral area can be prevented more effectively.

  The collagen tablet of the present invention is preferably PTP packaged. According to this aspect, a collagen tablet excellent in portability and storage stability can be obtained.

  The collagen tablet of the present invention is of a hardness that can be easily chewed, and has no adhesion of collagen in the teeth or oral cavity. Even ingestion is possible. Moreover, since it has sufficient hardness not to be difficult to handle, the tablet does not collapse while being carried or taken, and anyone can take it easily regardless of location. And since the collagen content per tablet is high, it is possible to ingest an amount of collagen that can be expected to have sufficient physiological activity with a small number of tablets.

  Collagen that can be used in the present invention is not particularly limited in its origin, extraction method, molecular weight and the like. For example, collagen obtained by extraction methods such as hot water extraction, pressure extraction, etc. can be used for the collagen contained in bones and skins of pigs, cows, chickens, etc. Can be used from those having a molecular weight of 100,000 or more to those having a peptide form of 1000 or less. Among these, from the viewpoint of absorption, collagen called a so-called collagen peptide having an average molecular weight of 10,000 or less is preferably used, and more preferably collagen having an average molecular weight of 1,000 to 4,000 is used. By using a collagen peptide having an average molecular weight of 10,000 or less, the absorption rate to the human body can be increased, and a more excellent physiological activity effect can be obtained.

  The collagen preferably has a free amino acid content in the solid content of 1.0% by mass or less and an arsenic content of 2 ppm or less. Since such collagen has already been used as an external preparation and supplement, there is no problem such as safety and it can be used with confidence. And, there is no peculiar taste and smell of the collagen raw material, and furthermore, since the arsenic content is very low as 2 ppm or less, the safety is high and it can be used in a wide range of fields.

  Fish-derived collagen can be obtained, for example, according to the method described in JP-A-2003-238597.

  Bonito, tuna, marlin, cod, horse mackerel, mackerel, salmon, trout, saury, eel, tilapia, kingfisher, grouper, halibut, flatfish, flatfish, herring, sardine, tilapia, shark, ray, pufferfish, yellowtail, scorpion, Collagen derived from fish can be obtained by adding water to fish skin and / or fish bones obtained from rockfish, etc., followed by heat extraction or pressure heat extraction. Among the above fish, it is preferable to use bonito, tuna, cod, tilapia, halibut, salmon and the like because they can be obtained stably in large quantities.

  The collagen peptide can be obtained by treating an extract containing collagen with a protein hydrolase to peptideize the collagen, treating it with a reverse osmosis membrane, and collecting the concentrated solution. Especially, it is preferable to add 1 to 10 times the amount of the original liquid, preferably 3 to 5 times the amount of water while adding water appropriately during the concentration to allow the liquid to permeate. By repeating the hydration operation, impurities can be removed more efficiently, and furthermore, the flavor peculiar to fish can be reduced, so that a safer collagen peptide can be obtained. As such a collagen peptide, trade name “Marine Matrix” (manufactured by Yaizu Suisan Chemical Co., Ltd.) and the like can be mentioned.

  The proteolytic enzyme used for the peptide formation of collagen is not particularly limited, and neutral protease, alkaline protease, acidic protease, or an enzyme preparation containing them can be used. Enzyme preparations are commercially available from various companies. For example, the product name “Protease N” (manufactured by Amano Enzyme, neutral protease), the product name “Protease P-3” (manufactured by Amano Enzyme, alkaline protease), the product name “ Sumiteam AP "(produced by Shin Nippon Chemical Industry Co., Ltd., acidic protease) can be used. Further, as the reverse osmosis membrane, those having a salt rejection of 10 to 50% are preferably used. Examples of such a reverse osmosis membrane include trade name “NTR-7410”, trade name “NTR-7430”, trade name “NTR-7450” (all manufactured by Nitto Denko).

  Further, when producing a collagen peptide having a desired average molecular weight, for example, by measuring the average molecular weight by a method such as a vapor pressure osmosis method, a light scattering method, an electrophoresis method, or a GPC-HPLC method, a desired average molecular weight is obtained. A molecular weight collagen peptide can be obtained.

  As a specific measuring method, for example, when measuring the average molecular weight of collagen peptide by GPC-HPLC method, GPC-HPLC apparatus (column: “TSK-gel guardcolumn PWXL” (manufactured by Tosoh Corporation), “TSK-gel” G3000PWXL "(manufactured by Tosoh Corporation)," TSK-gel G2500PWXL "(manufactured by Tosoh Corporation), mobile phase: 0.5% sodium chloride aqueous solution, flow rate: 0.8 mL / min, column temperature: 30 ° C., detection: RI , HPLC pump: “HITACHIL-7100 type” (manufactured by Hitachi, Ltd.), and as standard substances, laminaritetraose (molecular weight 660), laminarihexaose (molecular weight 990), pullulan pentamer (molecular weight 5,900) ), Pullulan decamer (molecular weight 11,800), pull Using down 20 mer (molecular weight 22,800), it can be determined from the relative molecular weight of these standards.

  The collagen tablet of the present invention contains 10 to 60% by mass of collagen. In addition, the content of collagen per tablet is preferably 200 to 1,800 mg, more preferably 200 to 1,200 mg, and most preferably 200 to 600 mg. When the collagen content is in the above range, a sufficient amount of collagen can be ingested with a small number of tablets. Moreover, since collagen hardly adheres to the oral cavity, the texture is not impaired.

  The collagen tablet of the present invention contains a water-insoluble calcium salt (A) having an average particle size of 50 μm or less and / or a poorly water-soluble polysaccharide (B) having an average particle size of 100 μm or less. By containing the water-insoluble calcium salt (A) and the poorly water-soluble polysaccharide (B), it is possible to prevent collagen from adhering to the oral cavity when the collagen tablet is chewed and eaten. The texture is improved. These may be blended singly, but by using the water-insoluble calcium salt (A) and the poorly water-soluble polysaccharide (B) in combination, collagen adhesion to the oral cavity can be more effectively prevented. Therefore, a collagen tablet having a better texture can be obtained.

  As the water-insoluble calcium salt (A), a calcium salt having a solubility of 0.1 g / 100 ml or less at normal temperature and neutral range and having an average particle diameter of 50 μm or less is used. When the average particle size exceeds 50 μm, the texture of calcium salt is strongly felt in the oral cavity, the powdery feeling and the rough feeling become strong, and the texture of the collagen tablet is impaired. In addition, when the solubility in the neutral range exceeds 0.1 g / 100 ml, it quickly dissolves in the oral cavity, collagen adhesion occurs, or a taste derived from calcium salt occurs, the texture of collagen tablets, Flavor deteriorates.

  The type of calcium salt is not particularly limited as long as it has the above physical properties and is acceptable for foods and pharmaceuticals. For example, if it is a foodstuff, a calcium carbonate, a calcium phosphate, etc. are mentioned. Examples of calcium carbonate include heavy calcium carbonate obtained by pulverizing limestone, light calcium carbonate synthesized from slaked lime, calcined calcium derived from eggshells, shells, and the like, and uncalcined calcium. Examples of calcium phosphate include fish bone-derived calcined calcium and uncalcined calcium. These calcium salts are commercially available, so long as they are unfired calcium derived from shells, the trade name “Sea Shell Ca” (Yaizu Suisan Kagaku Kogyo Co., Ltd.). (Yaizu Fisheries Chemical Co., Ltd.).

  And when the said water-insoluble calcium salt (A) is mix | blended with the collagen tablet of this invention, while preventing adhesion to collagen in an oral cavity, texture can be improved, bone strengthening, bone density of Synergistic effects with collagen are also expected in terms of improvement and prevention / improvement of osteoporosis.

  The poorly water-soluble polysaccharide (B) is a polysaccharide having a solubility in a neutral region of 1 g / 100 ml or less at 37 ° C., and an average particle size of 100 μm or less, more preferably an average particle size of 50 μm or less. Those having an average particle diameter of 20 μm or less are preferably used. When a water-soluble polysaccharide is used, it quickly dissolves in the oral cavity, causing collagen to adhere, or the polysaccharide itself adheres to the oral cavity, which deteriorates the texture of the collagen tablet. Even if it is a poorly water-soluble polysaccharide, if the average particle size exceeds 100 μm, the texture of the polysaccharide is strongly felt in the oral cavity, the powdery feeling and the rough feeling become strong, and the texture of the collagen tablet is increased. Damaged.

  The kind of polysaccharide in the poorly water-soluble polysaccharide (B) is not particularly limited as long as it has the above physical properties and is acceptable for foods and pharmaceuticals. Examples thereof include corn starch, tapioca starch, potato starch, sweet potato starch, wheat starch, legume starch, and starch such as rice starch. Among starches, corn starch and rice starch having a small particle size are particularly preferably used.

  The collagen tablet of the present invention preferably contains 10 to 60% by mass of the water-insoluble calcium salt (A) and the poorly water-soluble polysaccharide (B), more preferably 20 to 40% by mass. . When the total amount of these is less than 10% by mass, the adhesion of collagen to the oral cavity may not be sufficiently prevented. On the other hand, if it exceeds 60% by mass, the content of collagen and other excipients becomes low, the powdery powder feels strong in the oral cavity, and the texture of the collagen tablet may be impaired.

  The collagen tablet of the present invention can contain other components in addition to the above basic components as long as the taste and physical properties are not adversely affected. For example, arginine, taurine, glutamic acid, histidine, amino acids such as branched chain amino acids (leucine, isoleucine, valine), histidine, 1-methylhistidine, 3-methylhistidine, anserine, carnosine, homocarnosine, imidazole compounds such as valenin, Octacosanol, citric acid, acetic acid, chitin dimer, chitin pentamer, chitosan hexamer, oligoglucosamine, eicosapentaenoic acid, docosapentaenoic acid, docosahexaenoic acid, red pepper, ginseng, yeast zinc, yeast selenium, isoflavone, vitamins, etc. It can be used as appropriate. By blending these components, various physiological functions can be imparted.

  In addition, the collagen tablet of the present invention may be used as a tableting auxiliary material, as necessary, such as: (1) excipient (saccharide): starch degradation product such as dextrin, carrageenan, agar, alginic acid, guar gum, chitosan, xanthan gum, etc. Monosaccharides such as polysaccharides, sugar, glucose, lactose, maltose, disaccharides, fructooligosaccharides, maltooligosaccharides, isomaltooligosaccharides, galactooligosaccharides, chitin oligosaccharides, oligosaccharides such as chitosan oligosaccharides, maltitol, sorbitol, xylitol, Sugar alcohols such as erythritol, etc. (2) thickeners: guar gum, xanthan gum, locust bean gum, carrageenan, alginic acid, pectin, etc. (3) lubricant (emulsifier): sucrose fatty acid ester, magnesium stearate, stear Calcium phosphate, etc. (4) Others: Perfumes, pigments, etc. It can be used in a range that does not adversely affect the.

  The collagen tablet of the present invention has a mass per tablet of 1,000 to 3,000 mg, preferably 1,200 to 2,000 mg. When the weight per tablet is less than 1,000 mg, it is difficult to incorporate a sufficient amount of collagen in one tablet. On the other hand, when the mass per tablet exceeds 3,000 mg, the stability in tableting process is lowered, the quality stability is lowered, and furthermore, it is difficult to take one tablet with a bite.

  The collagen tablet of the present invention has a hardness of 5 to 13 kgf, preferably 7 to 9 kgf. If the hardness is less than 5 kgf, the tablet will collapse during the distribution and storage of the product. Moreover, when hardness exceeds 13 kgf, the disintegration property in the oral cavity at the time of ingestion will worsen, and it will become a tablet with a bad food texture as a result.

  Although the manufacturing method of the collagen tablet of this invention is not specifically limited, For example, it can manufacture by the following methods.

(1) Granulation step First, the raw material powder excluding the lubricant is mixed and granulated using water, ethanol or the like as a binder. The granulating method is not particularly limited, and a known method can be adopted, and examples thereof include a fluidized bed granulator, a stirring granulator, and an extrusion granulator. In addition, since processing conditions differ with the apparatuses to be used, what is necessary is just to determine suitably.

(2) Tableting molding process The raw material for tableting process which mixed the granulated material obtained at the said process and the lubricant as needed is shape | molded. The tableting molding method is not particularly limited, and a known method can be adopted, and a high-speed rotary tablet machine can be exemplified. Although the processing conditions vary depending on the apparatus used, the tablet hardness is 5 to 13 kgf, preferably the tablet hardness is 7 to 9 kgf, and the mass per tablet is 1,000 to 3,000 mg, preferably 1,200 to 2, It adjusts suitably so that it may become 000 mg.

  The collagen tablet of the present invention thus obtained is particularly suitable for use as a chewable tablet because it is difficult for collagen to adhere to the oral cavity when chewed and eaten, and it does not feel powdery. Can do. Moreover, it is preferable to package by PTP (Press Through Package) from the viewpoint of portability and storage stability and ease of taking out the tablet.

  EXAMPLES Hereinafter, the present invention will be specifically described with reference to examples, but these examples do not limit the scope of the present invention. In this example, the collagen peptide is trade name “Marine Matrix” (made by Yaizu Suisan Kagaku Kogyo Co., Ltd.), and the fish bone calcined calcium is trade name “fired Bonical” (made by Yaizu Suisan Kagaku Kogyo Co., Ltd .: average particle size 10 μm). )It was used.

(Test Example 1)
Using the raw materials for granulation processing shown in Table 1, granulation processing and drying were performed by a fluid granulation apparatus (trade name “Flow Coater”; manufactured by Freund Sangyo Co., Ltd.) according to a conventional method. Drying was performed at a temperature of 80 ° C. until the water content became 1% or less. After drying, the tableting raw materials shown in Table 1 were mixed and tableted with a tableting machine (trade name “VIRGO”; manufactured by Kikusui Seisakusho Co., Ltd.) at a tableting pressure of 1000 kg according to a conventional method. Processing was performed to produce collagen tablets (15 mm round, 1,000 mg / tablet). The hardness and texture of the obtained collagen tablet were evaluated, and the results are also shown in Table 1.
The hardness of the collagen tablet was measured using a hardness meter (trade name “FY-KD-20”, manufactured by Fuji Pharmaceutical Instruments Co., Ltd.) according to the Japanese hardness measurement method.
In addition, the texture of collagen tablets is sampled by five panelists, and the texture when chewed is divided into three levels for each of the two items of adhesion to the oral cavity and the feeling of powderiness and roughness ( (1 point: feel strong, 2 points: feel a little, 3 points: not feel at all).

Each of the tablets of Examples 1 to 4 had little adhesion in the oral cavity, powderiness and roughness, and Example 4 in which fish bone calcium and corn starch were used in combination was good.
On the other hand, in Comparative Example 1 using chitosan having an average particle size of 127 μm, the rough feeling of chitosan appeared strongly, and in Comparative Example 2, collagen adhered in the oral cavity, and the texture was all bad.

(Test Example 2)
Using the raw materials for granulation processing shown in Table 2, granulation processing and drying are performed by a fluid granulation device (product name “Flow Coater”; manufactured by Freund Sangyo Co., Ltd.) according to a conventional method. It was. Drying was performed at a temperature of 80 ° C. until the water content became 1% or less.
After drying, the tableting raw materials having the composition shown in Table 2 were mixed, and the tableting pressure (1000 kg, manufactured by Kikusui Seisakusho Co., Ltd.) with a tableting machine (trade name “TEGA 1024SS4-HY”) according to a conventional method was used. Tableting was performed to produce collagen tablets (20 mm round, 1,850 mg / tablet).

As in Test Example 1, the hardness of the tablet was measured and found to be 8 kgf. Moreover, as a result of tasting this tablet, it was easy to chew and no adhesion to the oral cavity was felt.
In addition, this tablet was subjected to PTP packaging according to a conventional method using a PTP packaging apparatus (trade name “HM-135”, manufactured by Techno Automatic Machine Works). PTP packaging was performed smoothly without any particular problems. And the shape of the tablet did not collapse at the time of taking out from PTP packaging during transfer or storage.

(Test Example 3)
Using raw materials for granulation processing having the composition shown in Table 3, granulation processing and drying by a fluid granulation apparatus (trade name “FD-WH (G) -60 type”, manufactured by POWRX) according to a conventional method. Went. Drying was performed at a temperature of 80 ° C. until the water content became 1% or less.
After drying, the raw materials for tableting with the composition shown in Table 3 were mixed, and the tableting machine (trade name “TEGA 1024SS4-HY”, manufactured by Kikusui Seisakusho Co., Ltd.) was used with a tableting pressure of 1000 kg according to a conventional method. Tableting was performed to produce collagen tablets (20 mm round, 1,850 mg / tablet).

As in Test Example 1, the hardness of the tablet was measured and found to be 8 kgf. Moreover, as a result of tasting this tablet, it was easy to chew and no adhesion to the oral cavity was felt.
In addition, this tablet was subjected to PTP packaging according to a conventional method using a PTP packaging apparatus (trade name “HM-135”, manufactured by Techno Automatic Machine Works). PTP packaging was performed smoothly without any particular problems. And the shape of the tablet did not collapse at the time of taking out from the PTP packaging during transfer or storage.

Claims (7)

A tablet containing collagen,
It contains a water-insoluble calcium salt (A) having an average particle size of 50 μm or less and / or a poorly water-soluble polysaccharide (B) having an average particle size of 100 μm or less, and the collagen content is 10 to 60% by mass, A collagen tablet, wherein the tablet has a hardness of 5 to 13 kgf and a mass per tablet of 1,000 to 3,000 mg.   The collagen tablet according to claim 1, wherein the collagen is a collagen peptide having an average molecular weight of 10,000 or less.   The collagen tablet according to claim 1 or 2, wherein the content of collagen per tablet is 200 to 1,800 mg.   The collagen tablet as described in any one of Claims 1-3 which contains 10-60 mass% of the said water-insoluble calcium salt (A) and the said slightly water-soluble polysaccharide (B) in total.   The collagen tablet according to any one of claims 1 to 4, wherein the water-insoluble calcium salt (A) is calcium carbonate and / or calcium phosphate.   The collagen tablet according to any one of claims 1 to 4, wherein the poorly water-soluble polysaccharide (B) is corn starch and / or rice starch.   The collagen tablet according to any one of claims 1 to 6, which is packaged in PTP.