JP2001288073A - Tablet and method for producing the same - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a tablet containing various active ingredients. SOLUTION: The objective tablet is produced by the direct tableting of a powdery mixture having particle diameter of <=850 μm, free from an emulsifier as a lubricant and containing 0.5-20 wt.% hardened oil and fat having a particle diameter of <=600 μm and exhibiting solid state at normal temperature, 3-70 wt.% collagen having particle diameter of <=500 μm and at least one powder component selected from glucosamine, calcium and isoflavone.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a tablet containing various active ingredients and a method for producing the tablet by efficient compression molding.

[0002]

2. Description of the Related Art Nutrients required to maintain human health are usually taken by eating and drinking natural products and the like.
A well-balanced or individually important component is often difficult. Therefore, tablets containing various nutrients have been conventionally developed, and intake of required nutrients has been facilitated. Here, various raw material powders as a base material and a nutritional component used in the production of tablets as described above have a high pressure binding property by itself, that is, a property of easily binding by tableting. (Such as sugar, glucosamine and soybean hypocotyl extract) and those having low pressure binding properties (such as starch and calcium). When these components are used alone or in combination, when they are compression-molded under pressure, the components bind (stick) to the light and shin of a tableting machine,
There is a problem that the surface of the obtained tablet is not shiny and unevenness is likely to occur, or a problem that compression molding cannot be performed unless excessive pressure is applied to obtain a certain strength. Further, there is a problem that the raw material powder has poor fluidity and adheres to a hopper or the like when filling the tableting machine. On the other hand, use of a lubricant has been proposed to solve the above-mentioned problems. By adding the lubricant as a raw material powder, the flowability of the raw material powder is improved, and the filling when filling the tablet of the tablet machine becomes good, and at the same time, the sticking during compression molding is prevented. be able to. In addition, since the lubricant plays a role of reducing the powder internal friction during compression molding and the friction between the powder and the light,
The compression pressure can be reduced, the discharge pressure is reduced, and the mechanical difficulty is reduced. However, sucrose esters, which are typical lubricants, have a health-oriented perspective.
It may be desirable not to use it as a food additive.
Therefore, the raw material powder is excellent in fluidity even when using a raw material powder having a high pressure binding property or a raw material powder having a weak bonding property, or when both are used in combination, so that the powder can be smoothly filled in a tableting machine. Therefore, there is a need for a technique for directly punching such raw material powders, which can easily be compression-molded, does not cause sticking, and can obtain tablets having a certain strength or more.

[0003]

SUMMARY OF THE INVENTION An object of the present invention is to provide tablets containing various active ingredients. In addition, the present invention provides that the raw material powder has excellent fluidity, the filling into the thinner of the tableting machine is smooth, the powder is easily compacted, and sticking, that is, when the surface of the tablet is peeled off. It is an object of the present invention to provide a method for producing a tablet satisfactorily, in which a phenomenon in which a part remains after adhesion is less likely to occur. Another object of the present invention is to provide a tablet which does not contain a food additive as a lubricant.

[0004]

The present invention is based on the finding that the above problems can be efficiently solved by using a specific raw material powder. That is, the present invention relates to a tablet comprising a raw powder mixture containing (A) hardened fat and oil solid at ordinary temperature and (B) collagen,
The tablet is produced by directly tableting the raw powder mixture. The present invention also relates to (A) a hardened vegetable oil which is solid at room temperature, (B) collagen and (C)
A tablet comprising a raw material powder mixture containing glucosamine and / or isoflavone, which is produced by directly tableting the raw material powder mixture. Further, the present invention provides at least one selected from the group consisting of 0.5 to 20% by mass of hardened fat and oil solid at room temperature having a particle size of 600 μm or less, 3 to 70% by mass of collagen having a particle size of 500 μm or less, and glucosamine, calcium and isoflavone. A raw material powder mixture containing a powder component of
Provided is a tablet obtained by directly compressing the powder mixture having a particle size of 850 μm or less. The present invention also provides a method for producing a tablet, which comprises directly tableting a raw powder mixture containing (A) a hardened fat and oil solid at room temperature and (B) collagen. In addition, the present invention provides a hardened fat and oil that is solid at room temperature with a particle size of 600 μm or less, 0.5 to 20% by mass, and a collagen with a particle size of 500 μm or less 3 to 70% by mass.
A raw powder mixture comprising at least one powder component selected from the group consisting of glucosamine, calcium and isoflavone, and directly tableting the powder mixture having a particle size of 850 μm or less. Provided is a method for manufacturing a tablet.

[0005]

DETAILED DESCRIPTION OF THE INVENTION In one embodiment of the present invention,
(A) a tablet containing a raw powder mixture containing a hardened fat and oil solid at room temperature and (B) collagen, which is produced by directly tableting the raw powder mixture; and (A) Hardened vegetable oils that are solid at room temperature,
A tablet comprising a raw powder mixture containing (B) collagen and (C) glucosamine and / or isoflavone, which is produced by directly tableting the raw powder mixture. here,
(A) As hardened oils and fats which are solid at normal temperature, rapeseed hardened oil,
Powdered raw materials such as vegetable oils and fats such as soybean hardened oil and animal fats and oils are listed, and vegetable oils and fats, particularly rapeseed hardened oil are preferred. The melting point is preferably from 50 to 100 ° C, more preferably from 60 to 80 ° C. The content of the component (A) is 0.5 to 20 based on the mass of the obtained tablet.
%, And more preferably from 1 to 10% by mass. Examples of (B) collagen include, for example, powdered raw materials obtained from beef bone, pig skin, and fish.
%, More preferably 5 to 50%
It is. (C) The powder raw materials such as glucosamine and / or isoflavone may be contained alone or in combination. For example, when glucosamine is used alone, its content in the tablet is preferably from 10 to 70%, more preferably from 30 to 60%. When isoflavone is used alone, its content in the tablet is preferably 0.1 to 50%, more preferably 10 to 30%.

In the tablet, the component (A) is a hardened fat or oil which is solid at room temperature,
It should have a particle size of m or less. Hardened oil and fat particle size 20μ
It is desirable that the size be not less than m. In addition, particle size 10
It is desirable that the particles have a particle size distribution of 50% or more near 0 μm. The component (B) collagen is 5
It preferably has a particle size of not more than 00 μm, or 2
It preferably has an average particle size of 0 to 200 μm. Further, in the tablet, the raw material powder mixture preferably has a size of 850 μm or less, more preferably 710 μm or less. In the present invention, the particle size refers to the amount of 100 g of a sample as defined by Japanese Industrial Standard Z.
8801 (1987), transferred to a sieve having the standard dimensions specified in 8801 (1987), vibrated for about 10 minutes, inspected whether or not to pass through the sieve, and defined by passing through the sieve with the standard dimensions. Things. In addition, this measurement method is based on the measurement method prescribed in Article 6 of the Japanese Agricultural Standards for Sugars.

[0007] In addition to the above components (A) to (C), optional components may be contained in the raw material powder mixture. Other optional components include, for example, starch, sugar, sugar alcohol,
Dextrin, dietary fiber, protein, agar, and the like. These contents can be appropriately determined according to the use. Further, it is preferable that the tablet does not contain an emulsifier itself such as a sucrose ester or a fatty acid ester as a lubricant. In addition, lubricants are used to improve the fluidity of raw material powders and to make molds for tableting machines (light).
And an additive for preventing the sticking of the raw material to the light and the shin at the same time as filling a certain amount into the inside.

[0008] In the present invention, "direct compression" means that the raw material powder is compression-molded by applying pressure directly to form a tablet. Therefore,
Such a tableting method is distinguished from a method in which a raw material powder is formed into a predetermined shape, for example, granules, and then the granules are tabletted to produce a tablet. The tableting machine that can be used for tablet production in the present invention is not particularly limited as long as it is a tableting machine that can produce a tablet by tableting the raw material powder as described above. Single-shot tablet presses and the like can be mentioned. Such a tableting machine usually has a function of measuring a certain amount of raw material powder and a function of compressing and molding the raw material powder. To measure a certain amount, a volumetric method can be used. That is, the space between the light and the shin can be filled with the powder raw material, and the raw material can be scrubbed with the lower surface of the feeder. In addition, tableting can be performed by mixing and stirring the raw material powders as described above to prepare a raw material powder mixture and directly compressing the mixture. In the present invention, the tableting is performed, for example, at a humidity of 10 to 50%, preferably 20 to 40%.
At a temperature of 10 to 30 ° C, preferably 15 to 25 ° C, 60 to 8000 particles / min, preferably 800 to 160
It can be performed at a speed of 0 pieces / min. In addition, tablets obtained by such tableting are 100 to 100 tablets per tablet.
The mass can be 1000 mg, preferably 200-300 mg.

In another embodiment of the invention, a particle size of 600
0.5-20% by mass of hardened fat and oil solid at normal temperature of μm or less,
A raw powder mixture comprising 3 to 70% by mass of collagen having a particle size of 500 μm or less and at least one powder component selected from the group consisting of glucosamine, calcium and isoflavone, wherein the powder has a particle size of 850 μm or less. There is provided a tablet obtained by directly compressing a body mixture. As the at least one powder component selected from the group consisting of glucosamine, calcium and isoflavone, glucosamine, calcium or isoflavone can be used alone, or two or more of them can be used.
Mixtures of more than one species may be used. Here, the powder component is 0.1% based on the mass of the obtained tablet.
The content is preferably 1 to 70%, more preferably 15%.
~ 65%. The preferred ranges of the particle size and content of the hardened fat and collagen and the size of the raw material powder mixture are the same as described above.

In still another aspect of the present invention, (A)
A tablet production method comprising directly tableting a raw powder mixture containing a hardened fat and oil solid at room temperature and (B) collagen, and 0.5 to 20% by mass of a hardened fat and oil solid at normal temperature having a particle size of 600 μm or less; 3 to 70% by mass of collagen having a particle size of 500 μm or less and at least one selected from the group consisting of glucosamine, calcium and isoflavone
A raw powder mixture containing various powder components, wherein the particle size is 85.
A method for producing a tablet is provided, comprising directly tableting the powder mixture having a size of 0 μm or less. Preferred examples of the particle size and content of the hardened fat and oil, the content of the powder component, the size of the powder raw material, and the tableting conditions are the same as those described above.

Next, an example of a tablet manufacturing method according to one embodiment of the present invention will be briefly described, but the manufacturing method of the present invention is not limited thereto. First, particle size 600μ
1 to 10% of hardened fats and oils solid at room temperature of not more than m, particle size 500
at least one selected from the group consisting of collagen and glucosamine, calcium and isoflavone having a size of not more than μm.
The raw powder mixture in which the respective powder components are uniformly dispersed by mixing 20 to 60% of the seed powder components is prepared. At this time, from the viewpoint of health, it is preferable not to add an emulsifier such as a sucrose ester as a lubricant. This raw material powder mixture is passed through, for example, a hopper and the mass per tablet obtained is 2.
Fill the mold formed by thinning at a ratio of 40 to 260 mg. This mold may have a desired shape, for example, it can be set according to the shape of the tablet to be obtained. Thereafter, direct compression is performed by directly applying pressure to the raw material powder mixture filled in the mold and compression molding. Tableting can be performed at a humidity of 10 to 50% and a temperature of 15 to 25 ° C. The tablet thus obtained may be in various forms, the form viewed from the top may be a circle, a square or a triangle, and the corners thereof may be rounded. Also, when viewed from the side,
Tableting can also be performed in various forms such as modified deep, special deep, extra deep, and standard. The hardness of the obtained tablet is preferably 2 kgf or more, more preferably 4 kgf or more.

[0012]

According to the present invention, tablets containing various raw material powders are provided. Further, the obtained tablet can be made to have a glossy surface or a small unevenness without using a food additive such as sucrose ester. In addition, a tablet suitable for health can be provided by not using a lubricant such as sucrose ester. Furthermore, in the production method of the present invention, the raw material powder has excellent fluidity, the filling into the powder of the tableting machine is smooth, the powder is easily compacted, and the sticking, that is, the surface of the tablet It is possible to provide a method capable of producing a tablet satisfactorily without causing a phenomenon that a part of the tablet is adhered and left when peeled off. For example, even when a raw material powder having a strong binding property and a raw material powder having a weak binding property are used arbitrarily, there is no sticking at the time of tableting,
Tablets having a certain hardness or higher can be manufactured.
For example, even a raw material powder such as glucosamine, which has a strong pressure binding property and is liable to cause sticking with a slight pressure rise, can be compression-molded without causing sticking. The tablet provided by the present invention can be swallowed and ingested with water, for example, in the same manner as a drug tablet.

[0013]

Example 1 8 parts of rapeseed oil having a particle size of 600 μm or less (average particle size 70 μm), 42 parts of collagen having a particle size of 500 μm or less (average particle size 100 μm), and glucosamine having a particle size of 850 μm or less (average particle size 100 μm) 50 parts were mixed and stirred to prepare a raw material powder mixture in which each component was uniformly dispersed. This raw material powder mixture is converted into a tableting machine (model HT-
AP18SS2) was filled into a thin layer and tableted. The tableting conditions at this time were a humidity of 45%, a temperature of 25 ° C., a speed of 720 tablets / min, and a rate of 250 mg / table. The raw material powder mixture had a high fluidity, was smoothly filled into the thinner of a tableting machine, and was able to favorably compact the powder. In addition, sticking did not occur during the production, and a tablet having a desired shape with a glossy surface and no irregularities could be produced. Incidentally, the strength of the obtained tablet was 8 kgf.

Example 2 3 parts of rapeseed oil having a particle size of 600 μm or less (average particle size 70 μm), 10 parts of collagen having a particle size of 500 μm or less (average particle size 100 μm), and a particle size of 300 μm or less (average particle size 20)
(μm) of calcium and 27 parts of starch were mixed and stirred to prepare a raw material powder mixture in which each component was uniformly dispersed. This raw material powder mixture was tableted under the same conditions as in Example 1. The raw material powder mixture had a high fluidity, was smoothly filled into the thinner of a tableting machine, and was able to favorably compact the powder. In addition, sticking did not occur during the production, and a tablet having a desired shape with a glossy surface and no irregularities could be produced. In addition, the strength of the obtained tablet was 20 kgf or more.

Example 3 5 parts of rapeseed oil having a particle size of 600 μm or less (average particle size of 70 μm), 10 parts of collagen having a particle size of 500 μm or less (average particle size of 100 μm), and a soybean hypocotyl extract (isoflavone) having a particle size of 850 μm or less 20 Parts and sugar (trehalose) 65
The components were mixed and stirred to prepare a raw material powder mixture in which each component was uniformly dispersed. This raw material powder mixture was tableted under the same conditions as in Example 1. The raw material powder mixture had a high fluidity, was smoothly filled into the thinner of a tableting machine, and was able to favorably compact the powder. In addition, sticking did not occur during the production, and a tablet having a desired shape with a glossy surface and no irregularities could be produced. In addition, the strength of the obtained tablet was 9 kgf.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 31/7008 A61K 31/7008 4C206 33/06 33/06 38/00 47/42 47/42 A61P 3 / 02 A61P 3/02 A61K 37/02 (72) Inventor Tetsuya Yamada 1-1-1 Kano-Sakuradacho, Gifu City, Gifu Prefecture Inside API Co., Ltd. (72) Inventor Morikazu Izumi 1-5, Mikitei-Sakaecho, Higashi-Osaka City, Osaka Prefecture No. 7 Inside House Foods Co., Ltd. (72) Inventor Yasuhiro Tomita 1-5-7 Mikitei Sakaecho, Higashiosaka-shi, Osaka House Foods Co., Ltd. F-term (reference) 4B018 LE01 MD04 MD07 MD14 MD20 MF08 4B048 PE03 PL02 PL11 PS18 4C076 AA37 BB01 CC40 EE43 FF36 GG14 4C084 AA03 AA21 BA03 CA17 DC50 MA02 MA35 MA52 NA03 ZC212 4C086 AA02 BA08 EA01 HA04 MA03 MA04 NA03 ZC21 4C206 AA02 DB06 DB48 MA03 MA04 MA55 MA72 NA03 ZC21

Claims (6)

[Claims] 1. A hardened fat or oil which is solid at normal temperature and (B)
A tablet comprising a raw material powder mixture containing collagen, wherein the tablet is produced by directly tableting the raw material powder mixture. 2. A tablet comprising (A) a hardened fat or oil which is solid at ordinary temperature, (B) collagen, and (C) a raw material powder mixture containing glucosamine and / or isoflavone, wherein the raw material powder mixture is directly pressed. The tablet manufactured by tableting. 3. A hardened fat or oil solid having a particle size of 600 μm or less at room temperature, 0.5 to 20% by mass, collagen having a particle size of 500 μm or less, 3 to 70% by mass, and at least one selected from the group consisting of glucosamine, calcium and isoflavone. A raw material powder mixture containing a powder component, wherein the particle size is 850.
A tablet obtained by directly compressing the powder mixture having a size of not more than μm. 4. The tablet according to claim 1, which does not contain an emulsifier itself as a lubricant. 5. A hardened oil and fat which is solid at normal temperature and (B)
A method for producing a tablet, comprising directly tableting a raw material powder mixture containing collagen. 6. At least one member selected from the group consisting of 0.5 to 20% by mass of hardened fat and oil solid at room temperature having a particle size of 600 μm or less, 3 to 70% by mass of collagen having a particle size of 500 μm or less, and glucosamine, calcium and isoflavone. A raw material powder mixture containing a powder component, wherein the particle size is 850.
A method for producing a tablet, comprising directly tableting the powder mixture having a size of not more than μm.