JP3483536B2 - Tablet manufactured by direct compression and manufacturing method thereof - Google Patents

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a tablet produced by directly compressing a raw material powder mixture having a specific composition, and a method for producing the tablet.

[0002]

2. Description of the Related Art The nutritional components required to maintain human health are usually ingested by eating and drinking natural products,
A well-balanced intake or intake of individually important ingredients is often difficult. Therefore, conventionally, tablets containing various nutritional components have been developed to facilitate the intake of the required nutritional components. Here, it is desired to use various raw material powders as the nutritional components used in the production of the tablets as described above, but when these raw material powders themselves are pressure-bondable components, or raw material powders When the adhesive composition contains a pressure-bonding component, the following problems may occur. That is, when such raw material powders are used alone or in combination, the raw material powder itself or the pressure-bonding component contained therein is bound to a thin tablet of a tableting machine by tableting (compression molding). (Sticking), the surface of the obtained tablet is not glossy and unevenness is likely to occur. still,
The problem of such sticking becomes significant when directly tableting. When a raw material powder containing such a pressure-bonding component is used, the raw material powder or a raw material powder mixture containing the raw material powder has poor fluidity and adheres to a hopper or the like during filling into a tableting machine. There is also the problem of doing.

On the other hand, the use of lubricants has been proposed to solve the above problems. By adding a lubricant as the raw material powder, the fluidity of the raw material powder is improved and the filling when filling the thin of the tableting machine becomes good, and at the same time, sticking during compression molding is prevented. be able to. Further, the lubricant plays a role of reducing internal friction of the powder during compression molding and friction between the powder and the thin powder, so that the compression pressure can be lowered and the discharge pressure also becomes small, resulting in mechanical difficulty. Is also reduced. However, as a lubricant,
From a health-oriented viewpoint, it is desired not to use food additives. Therefore, when using a raw material powder containing a pressure-bonding component, especially a raw material powder mixture containing a high content of the raw material powder, excellent fluidity, smooth filling into the thin of the tabletting machine, There is a need for a direct compression technique that enables easy compression molding when directly compressing these raw material powder mixtures, does not cause sticking, and can obtain a tablet having a certain strength or more. Further, in the tablet production method by direct compression, it is the present situation that it is necessary to make the hardness desired by using a component called an excipient. However, when such an excipient is used in a large amount, the ratio of the active ingredient (nutrition material) desired to be included in the tablet decreases. Therefore, it would be convenient if tablets could be produced using raw materials consisting of only active ingredients (nutrient ingredients) without using excipients.

[0004]

SUMMARY OF THE INVENTION It is an object of the present invention to provide a tablet and a method for manufacturing the tablet, which efficiently solve the above problems.

[0005]

The present invention is based on the finding that the above problems can be solved by combining a raw material powder containing a pressure-bonding component with a specific raw material powder. That is, the present invention is a tablet produced by directly compressing a raw material powder mixture, wherein the raw material powder mixture contains (A) a raw material powder containing a pressure-bonding component, and (B) a food product. Provided is a tablet comprising a calcium raw material powder for use and a collagen raw material powder (C).
The present invention also provides (A) a raw material powder containing a pressure-bonding component,
Provided is a method for producing a tablet, which comprises mixing (B) a calcium raw material powder for food and (C) a collagen raw material powder and directly compressing the raw material powder mixture.

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION First, the tablet of the present invention is
It is produced by directly compressing the raw material powder mixture. Here, "direct compression" means that the raw material powder mixture is directly pressed to be compression molded into a tablet form. Therefore, such a tableting method is distinguished from a method in which the raw material powder is formed into a predetermined shape, for example, once in the form of granules, and then the granules are tableted to produce tablets. Further, the "raw material powder mixture" means
It contains (A) a raw material powder containing a pressure binding component, (B) a calcium raw material powder for food and (C) a collagen raw material powder.

In the present invention, as the raw material powder containing the (A) pressure-bonding component, the raw material powder itself is a pressure-binding component, and the pressure-bonding component is a component in the raw material powder. Both cases are included. Here, the pressure-bonding component is a component capable of binding (sticking) to a thin crevice of a tableting machine when it is used alone or in combination and compressed (compression molding) under pressure. Say. A raw material powder containing a component having such a property has hitherto been used because of its binding property.
Even when it is desired to use it as an effective component, its use for direct compression of the tablet was avoided, but it can be favorably used in the present invention. In the present invention, as the raw material powder containing the (A) pressure-bonding component, for example, royal jelly powder, DHA (docosahexaenoic acid) powder or saw palmetto powder can be used, and royal jelly is preferably used. here,
Royal jelly is secreted from the pharyngeal glands by the worker bees in the royal platform of the bee hive and is also called royal milk. Its general composition is 50-60% water, 18% protein and 15% hydrous carbon. , Fat about 6%, ash about 1.5%, the appearance is a white pasty fluid with a sour taste. This powder can be obtained, for example, by lyophilizing and pulverizing royal jelly (fluid) by a conventional method. (A) The raw material powder containing the pressure-bonding component is Raw material powders other than royal jelly having the same component composition are included. DHA means docosahexaenoic acid,
This can be obtained from oil obtained from one of herrings, phospholipid of mammalian brain, bovine liver and the like. Sawtooth palm is a kind of small palm distributed in the southeastern part of North America, has sawtooth-like leaves and has olive type red fruits containing a lot of oily substances, and this fruit is edible. , as a raw material for medicine.

Further, in the present invention, the raw material powder mixture contains 30 to 7 raw material powders containing (A) the pressure-bonding component.
The content is preferably 0% by mass (hereinafter, simply referred to as%), and more preferably 30 to 60 % . Also, (A)
The size of the raw material powder containing the pressure-bonding component is not particularly limited as long as it can be used for direct compression of tablets, and for example, its particle size is 85.
It is preferably 0 μm or less, and more preferably 355 μm or less. The average particle size is also not particularly limited, but is preferably, for example, 50 to 200 μm, more preferably 100 to 150 μm. In the present invention, the particle size means whether or not 100 g of a sample is transferred to a mesh sieve having a standard size specified in Japanese Industrial Standard Z8801 (1987), and after being vibrated for about 10 minutes, it passes through a sieve. It is stipulated by inspecting and passing through a standard size screen. still,
This measurement method is in accordance with the measurement method specified in Article 6 of the Japanese Agriculture and Forestry Standard for sugars.

In the present invention, the calcium raw material powder for food (B) can be used without any particular limitation as long as it can be included in food as a calcium feed material. Mention may be made of milk calcium, egg shell calcium, bovine bone calcium, coral calcium and the like. In the present invention, it is preferable to use a natural calcium raw material powder, for example, milk calcium. Further, it is preferable that the raw material powder mixture contains 1 to 20% of (B) food-grade calcium raw material powder,
It is more preferably 3 to 15%. The size of the (B) calcium raw material powder for foods is not particularly limited as long as it can be used for direct compression of tablets, and for example, the particle size thereof is 850 μm or less. Is preferably 150 μm or less, more preferably 150 μm or less. The average particle diameter is not particularly limited, but is preferably 5 to 100 μm, more preferably 10 to 50 μm.

Examples of the collagen raw material powder (C) in the present invention include raw material powders obtained from beef bones, pig skin, and fish. The raw material powder mixture preferably contains 10 to 69% of the collagen raw material powder (C), more preferably 30 to 60%. In the present invention, the ratio of (A) raw material powder to (C) collagen raw material powder is preferably 70:10 to 10:70, more preferably 60:30 to 30:60. . The size of the collagen raw material powder (C) is not particularly limited as long as it can be used for direct compression of tablets, and for example, the particle size thereof is 850 μm or less. It is preferably 500 μm or less. Also, the average particle size is not particularly limited,
For example, it is preferably 20 to 200 μm,
More preferably, it is 50 to 150 μm.

In the present invention, the above (A) to
In addition to (C), excipients that have been conventionally used in the production of tablets, that is, those having a shaping function for shaping the raw material powder into an appropriate hardness after tableting, for example, It is preferable not to use starch, sugar, sugar alcohol, dextrin, dietary fiber, gelatin, protein and agar. That is, in the present invention, it is preferable to manufacture a tablet using a raw material powder mixture consisting of only the above (A) to (C). This is preferable because any one of the above (A) to (C), for example, (A) raw material powder can be contained in a high content. When an excipient is included, it is preferably less than 30%. Further, in the present invention, a high quality tablet can be produced without containing a sucrose fatty acid ester as a lubricant. When using a lubricant, it is preferable to use a substance other than sucrose fatty acid ester, for example, hardened oil and fat. Examples of the hardened oil include hardened oils and fats that are solid at room temperature, such as rape hardened oils and fats, soybean hardened oils and fats, lard and heads. When the hardened oil and fat is used, the particle size thereof is preferably 850 μm or less, more preferably 600 μm or less. Further, the average particle size thereof is preferably 50 to 200 μm,
More preferably, it is 70 to 120 μm. In addition, in the present invention, the lubricant means that the fluidity of the raw material powder is improved so that a certain amount is filled in the mold (thin) of the tablet machine, and at the same time, the raw material is thinned. It is an additive for preventing sticking that adheres to the.

In the present invention, the above ingredients are mixed and stirred to prepare a raw material powder mixture, which is then directly tableted to produce tablets. Mixing and stirring can be performed by a conventional method. In addition, tableting conditions are such that the humidity is 10 to 50%,
It is preferably 20 to 40% and a temperature of 5 to 30 ° C., preferably 10 to 25 ° C., and a speed of 60 to 8000 pieces / minute, preferably 500 to 1500 pieces / minute. In addition, the tablets obtained by such tableting are 100 to 1000 mg, preferably 20 tablets per tablet.
It can be a mass of 0 to 300 mg. The tableting machine that can be used for tablet production in the present invention is not particularly limited as long as it is a tableting machine that can produce tablets by tableting the raw material powder as described above.
Examples thereof include a rotary tableting machine and a single-shot tableting machine. Such a tableting machine usually has a function of measuring a fixed amount of the raw material powder and a function of compression-molding it. The volumetric method can be used to weigh a fixed amount. That is, it is possible to fill the space between the thin and the bottom ridge with the powder raw material and scrape it with the lower surface of the feeder.
The tableting is performed by mixing and stirring the raw material powder as described above,
It can be carried out by preparing a raw material powder mixture and directly compressing it.

Next, an example of a method of manufacturing a tablet according to one aspect of the present invention will be briefly described, but the manufacturing method of the present invention is not limited to this. First, (A) 30-70% of raw material powder containing a pressure binding component, (B) 1-20% of calcium raw material powder for food and (C) 10-69% of collagen raw material powder are mixed and stirred. A raw material powder mixture in which each raw material powder is uniformly dispersed is prepared. At this time, from the viewpoint of health, it is preferable not to add sucrose ester or the like as a lubricant. The raw material powder mixture is passed through, for example, a hopper and the mass per tablet obtained is 240 to 2
The mold formed by thinning and filling is filled at a ratio of 60 mg. This mold may have a desired shape and can be set, for example, according to the shape of the tablet to be obtained. Thereafter, the raw material powder mixture filled in the mold is directly applied with pressure to perform compression molding under a predetermined condition, thereby directly compressing. The tablets thus obtained may have various forms, and the form viewed from the top may be a circle, a square, or a triangle, and their corners may be rounded. Further, when viewed from the side, tablets can be formed into various forms such as modified deep, special deep, extra deep, and standard. The hardness of the obtained tablet is 2 kg.
It is preferably at least f, more preferably at least 4 kgf.

[0014]

According to the present invention, there is provided a high quality direct tableting type (plain tablet) tablet containing (A) a raw material powder containing a pressure binding component such as royal jelly and having a predetermined hardness. be able to. The tablet of the present invention is of high quality with a glossy surface and no irregularities. Further, in the present invention, it becomes possible to incorporate a high amount of the raw material powder (A) containing a pressure-binding component such as royal jelly into a tablet. Further, in the present invention, without using various excipients and sucrose fatty acid ester as a lubricant,
Even when only the nutritional material is used, the above high-quality tablet can be obtained without causing the problem of sticking. The tablet of the present invention can absorb a nutritional material by ingestion. Hereinafter, the present invention will be described in detail with reference to Examples, but the present invention is not limited to the following Examples.

[0015]

EXAMPLES Example 1 60 parts of royal jelly powder having a particle size of 355 μm or less and an average particle size of 120 μm, and an average particle size of 50 μm with a particle size of 150 μm or less
m milk calcium 9 parts, particle size 500 μm or less, average particle size 100 μm collagen 30 parts, and particle size 600 μm
1 part of rapeseed oil having an average particle size of 70 μm and having a particle diameter of m or less was mixed and stirred to prepare a raw material powder mixture in which each component was uniformly dispersed. This raw material powder mixture was filled into the thin of a tableting machine (Model HT-AP18SS2) manufactured by Hata Co., Ltd., and tableting was performed. The tableting conditions at this time are: humidity 45%, temperature 2
The rate was 250 mg / piece at a temperature of 5 ° C. and 720 pieces / minute. The raw material powder mixture had a high fluidity, the filling into the thin of the tableting machine was smooth, and the powder could be satisfactorily compression-molded.
In addition, sticking did not occur during production, and a tablet having a desired shape with a glossy surface and no unevenness could be produced. The strength of the obtained tablets is 1
It was 5 kgf.

Example 2 A tablet was prepared in the same manner as in Example 1 except that 10 parts of milk calcium was used and no hydrogenated rapeseed oil was used.
The tablet has the same quality as that obtained in Example 1 and is a new and health-oriented tablet that is made of only nutritional materials without using conventional excipients and lubricants or food additives. It was

Example 3 A tablet was produced in the same manner as in Example 1 except that 35 parts of royal jelly powder, 4 parts of milk calcium, 60 parts of collagen and 1 part of rapeseed oil were used. The tablets had a quality comparable to that obtained in Example 1.

─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Yasuhiro Tomita 1-5-7 Mikitei-cho, Higashi-Osaka City, Osaka Prefecture House Foods Co., Ltd. (72) Inventor Shuichiro Ito 1-5, Mikitei-cho, East Osaka No. 7 House Food Co., Ltd. (56) Reference JP-A-3-251162 (JP, A) (58) Fields investigated (Int.Cl. ⁷ , DB name) A23L 1/00 A23L 1/076 A23L 1 / 304 A61K 9/20

Claims (6)

(57) [Claims] 1. A tablet produced by directly compressing a raw material powder mixture, wherein the raw material powder mixture comprises (A) a raw material powder containing a pressure-bonding component, and (B) a food product. The tablet containing calcium raw material powder and (C) collagen raw material powder. 2. The raw material powder mixture contains 30 to 70 mass% of royal jelly as the raw material powder (A).
The listed tablet. 3. The tablet according to claim 2, wherein the raw material powder mixture contains (B) 1 to 20% by mass of food grade calcium raw material powder and (C) 10 to 69% by mass of collagen raw material powder. 4. The tablet according to claim 1, wherein the (B) calcium raw material powder for food is milk calcium. 5. The raw material powder mixture is the raw material powder (A) to
The tablet according to any one of claims 1 to 4, which comprises only (C). 6. A raw material powder containing (A) a pressure-bonding component,
A method for producing a tablet, which comprises mixing (B) a calcium raw material powder for food and (C) a collagen raw material powder and directly compressing the raw material powder mixture.