JP4100468B2 - Method for producing tablets by tableting raw material powder mixture - Google Patents

Description

[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a method for producing a tablet capable of ingesting a predetermined active ingredient.
[0002]
[Prior art]
Nutritional components required for maintaining human health are usually ingested by eating and drinking natural products and the like, but it is often difficult to have a balanced intake or intake of individually important components. Therefore, conventionally, tablets containing various nutritional components have been developed, and it is easy to ingest the required nutritional components.
Here, it is desirable to use various raw material powders as nutritional components used in the manufacture of the tablet as described above, but when using raw material powders that are easily consolidated due to moisture absorption, they are consolidated. The raw material powder is sparsely scattered in the tablet. Such a product not only does not have a good appearance, but also the problem of discoloration during storage can be significant due to the exudation of the extract component from the consolidated raw material.
In addition, raw powder such as propolis is obtained by tableting (compression molding) by binding (sticking) the raw powder itself or the components contained therein to the thinning of the tableting machine. There is a problem that the surface is not glossy and irregularities are generated. Such a sticking problem becomes prominent when direct tableting is performed. In addition, when such raw material powder is used, the raw material powder or the raw material powder mixture containing the raw material powder is poor in fluidity, and there is a problem that it adheres to a hopper or the like during filling into a tableting machine.
[0003]
On the other hand, in order to solve the problem of consolidation due to moisture absorption, the use of finely divided silicon dioxide is considered, and in order to solve the problem of sticking, the use of a lubricant is also proposed. By adding a lubricant as a raw material powder, the flowability of the raw material powder is improved and the filling when filling into the tablet machine is good, and at the same time, sticking during compression molding is prevented. be able to. In addition, the lubricant plays a role in reducing the internal friction of the powder during compression molding and the friction between the powder and the powder, so that the compression pressure can be lowered, the discharge pressure is reduced, and mechanical difficulty is reduced. Is also reduced. However, as a lubricant and the like, it is desired not to use food additives from a health-oriented viewpoint.
[0004]
[Problems to be solved by the invention]
An object of the present invention is to efficiently solve the above-described problems and provide a method for producing a tablet capable of ingesting a predetermined active ingredient.
[0005]
[Means for Solving the Problems]
The present invention is a method for producing a tablet by tableting a raw material powder mixture, at least one raw material powder selected from the group consisting of propolis, sugar, fruit juice powder, plant extract and seasoning, This is based on the knowledge that the above-mentioned problem can be efficiently solved by premixing with raw material powder which is hard to be consolidated even if it absorbs moisture.
That is, the present invention comprises (A) at least one raw material powder selected from the group consisting of propolis, saccharides, fruit juice powder, plant extract and seasoning, and (B) a raw material powder that is difficult to consolidate even after moisture absorption. Is then premixed, and then mixed with (C) other raw material powders for tableting to prepare a raw material powder mixture, and a tablet manufacturing method is provided. To do.
[0006]
DETAILED DESCRIPTION OF THE INVENTION
First, in the production method of the present invention, (A) at least one raw material powder selected from the group consisting of propolis, saccharides, fruit juice powder, plant extract, and seasoning, and (B) a raw material that is hard to absorb and solidify. Premix with powder.
(A) Raw material powder is 1 type chosen from the group which consists of propolis, saccharides, fruit juice powder, a plant extract, and a seasoning, and these are easy to solidify when it absorbs moisture. (A) The raw material powder may be a single raw material or a mixture of a plurality of raw materials. (A) Propolis is preferably used as the raw material powder. Further, (A) the raw material powder is preferably contained in the raw material powder mixture to be tableted in an amount of 5 to 30% by mass (hereinafter simply referred to as%), more preferably 5 to 20%. (A) The size of the raw material powder is not particularly limited as long as it can be normally used for tableting of tablets, but for example, the particle size is preferably 850 μm or less, More preferably, it is 355 μm or less. Moreover, although the average particle diameter is not specifically limited, For example, it is preferable to set it as 20-200 micrometers, More preferably, it is 50-150 micrometers. In the present invention, the particle size refers to whether or not the amount of 100 g of a sample is transferred to a mesh sieve having a standard size specified in Japanese Industrial Standard Z8801 (1987), and after passing through a sieve for about 10 minutes, is passed. It is defined by inspection and passing through sieves of the reference dimensions. In addition, this measuring method is based on the measuring method prescribed | regulated to Japanese Agricultural Standards Article 6 of saccharides.
[0007]
(A) When the raw material powder is larger than the above range, it is preferably finely pulverized with various fine pulverizers so as to have a size within the above range. Further, (A) the raw material powder is preferably preliminarily mixed with (B) the raw material powder immediately after pulverization, that is, before the solidification occurs. When propolis is used as the raw material powder (A), the powder is extracted by a conventional method, for example, after extracting the raw material lump (original lump) with ethanol, etc. The raw material powder having a size within the above range can be obtained by pulverization. As a means for fine pulverization, for example, pulverizers such as a power mill, a hammer mill, and a pin mill can be used. Alternatively, the propolis powder can be easily obtained on the market, and it may be used as it is or finely pulverized as the raw material powder (A).
[0008]
In addition, as the raw material powder (B), a raw material powder that is hard to be consolidated even when moisture is absorbed is used. Such (B) raw material powder is preferably at least one selected from the group consisting of collagen, starches and dextrins. Examples of collagen include those obtained from cow bones, pig skin, and fish. Examples of the starch include starch obtained from potato, tapioca and corn. Examples of the dextrin include those obtained from starch derived from potato and tapioca. (B) The raw material powder is most preferably collagen. Moreover, the usage-amount of (B) raw material powder can be determined by the ratio with (A) raw material powder as follows. (B) The size of the raw material powder is not particularly limited as long as it can be normally used for tableting of tablets, but for example, the particle size is preferably 850 μm or less, More preferably, it is 500 μm or less. Moreover, although the average particle diameter is not specifically limited, For example, it is preferable to set it as 20-200 micrometers, More preferably, it is 50-150 micrometers. The raw material powder (B) having such a particle size and average particle size can be produced by a conventional method, or can be easily obtained on the market.
[0009]
The premixing of (A) raw material powder and (B) raw material powder as described above is preferably performed so that the ratio of (A) :( B) is 10:50 to 10: 5. Preferably it is 10: 40-10: 20. Premixing can be performed by a conventional method. For example, the mixing conditions are a temperature of 5 to 30 ° C., preferably 10 to 25 ° C., a humidity of 10 to 50%, preferably 20 to 40%, and a rotational speed of 15 to 25 rpm. , Preferably, it can be 10 to 30 minutes, preferably 20 to 25 minutes at 20 to 25 rpm. Preliminary mixing can be performed by processing in a predetermined mixer. As the mixer, for example, a V-type mixer or a rocking mixer can be used. In this case, it is preferable that (A) the powder raw material is not consolidated by moisture absorption.
[0010]
In the present invention, (A) the raw material powder and (B) the raw material powder are premixed and then mixed with (C) another raw material powder for tableting to prepare a raw material powder mixture. Here, as the raw material powder (C), arbitrary raw materials for tableting such as excipients, lubricants and various nutritional components can be used alone or in any combination. Excipients are those that have a shaping function for shaping the raw material powder into an appropriate hardness after tableting. For example, collagen, starch, sugar, sugar alcohol, dextrin, dietary fiber, gelatin, protein And agar. The excipient is preferably contained at 40 to 90%, more preferably 50 to 70%, in the raw material powder mixture to be tableted. In addition, when these excipients can also be used as the (B) raw material powder, a part thereof is preliminarily mixed in an amount determined by the ratio with the (A) raw material powder. The remaining amount may be used when (C) other raw material powder is mixed. The size of the excipient is not particularly limited as long as it can be used for tableting of tablets. For example, the particle size is preferably 850 μm or less, more preferably 355 μm or less. Moreover, although the average particle diameter is not specifically limited, For example, it is preferable to set it as 20-200 micrometers, More preferably, it is 50-150 micrometers. The excipient | filler which has such a particle size and an average particle diameter can be manufactured by a conventional method, or can be obtained easily on the market.
[0011]
In the present invention, it is preferable not to include a sucrose fatty acid ester as a lubricant. When using a lubricant, it is preferable to use other than sucrose fatty acid ester, for example, hardened fats and oils. Examples of the hardened oil include hardened fats and oils that are solid at room temperature, such as rapeseed hardened fats and oils, soybean hardened fats and oils, lards, and heads. When using hardened fats and oils, its content in the raw material powder mixture is preferably 0.5 to 10%, more preferably 1 to 5%, and its particle size is preferably 850 μm or less. It is good that the thickness is 600 μm or less. Moreover, it is preferable that the average particle diameter is 50-200 micrometers, More preferably, it is 70-120 micrometers. In the present invention, the lubricant means that the flowability of the raw material powder is improved so that a certain amount is filled into the die of the tableting machine, and at the same time, the raw material is lightened. It is an additive for preventing sticking that adheres to the surface.
In addition, in this invention, arbitrary components other than the above can be included, and vitamins etc. can be included as various nutrient components.
[0012]
The (A) raw material powder and the (B) raw material powder premix and (C) the other raw material powder can be mixed under the same conditions as in the premixing. Thereby, a raw material powder mixture in which each component is uniformly dispersed can be prepared. Under the present circumstances, it is preferable to carry out so that the ratio of (A) :( B) :( C) may become 5-30: 5-60: 40-90 in a raw material powder mixture, More preferably, it is 5 -20: 20-40: 50-70.
[0013]
In this invention, a tablet is manufactured by tableting the raw material powder mixture prepared as mentioned above. Although tableting can be performed by a conventional method, it is preferably performed by direct tableting. “Direct tableting” means that the raw powder mixture is directly compressed to form a tablet by compression molding. Therefore, such a tableting method is distinguished from a method in which a raw material powder is formed into a predetermined shape, for example, a granule, and then the granule is tableted to produce a tablet.
The tableting conditions are, for example, a humidity of 10 to 50%, preferably 20 to 40%, a temperature of 5 to 30 ° C, preferably 10 to 25 ° C, and 60 to 8000 pieces / minute, preferably 630. A speed of ˜1400 / min is preferable. Moreover, the tablet obtained by such tableting can be made into the mass of 100-1000 mg per piece, Preferably it is 200-300 mg. Although it does not restrict | limit especially as a tableting machine which can be used for tablet manufacture in this invention, For example, a rotary tableting machine, a single tableting machine, etc. are mentioned. Such a tableting machine usually has a function of weighing a certain amount of the raw material powder and a function of compressing it. The volumetric method can be used to weigh a certain amount. That is, it is possible to fill the space between the light and the lower knee with the powder raw material, and to rub it on the lower surface of the feeder. Tableting can be performed by mixing and stirring the raw material powder as described above to prepare a raw material powder mixture and directly tableting it.
[0014]
Next, although an example of the manufacturing method of the tablet which is 1 aspect of this invention is demonstrated easily, the manufacturing method of this invention is not limited to this.
First, (A) at least one raw material powder selected from the group consisting of propolis, sugar, fruit juice powder, plant extract, and seasoning, and (B) a raw material powder that is hard to be consolidated even after moisture absorption: Premix at a ratio of 50 to 10: 5. This is mixed with (C) another raw material powder for tableting, and a raw material powder mixture in which the ratio of (A) :( B) :( C) is 5-30: 5-60: 40-90 is obtained. Prepare. At this time, it is preferable not to add silicon dioxide, sucrose ester or the like from the viewpoint of health. This raw material powder mixture is filled, for example, through a hopper, into a mold formed by thinning at a rate such that the mass per tablet obtained is 240 to 260 mg. This mold may have a desired shape, and can be set according to the shape of the tablet to be obtained, for example. Thereafter, direct compression is performed by directly applying pressure to the raw material powder mixture filled in the mold and compression molding under predetermined conditions. The tablet thus obtained may have various forms, the form seen from the top may be a circle, a quadrangle, or a triangle, and the corners may be rounded. In addition, when viewed from the side, the tablet can be tableted in various forms such as modified deep, special deep, extra deep, and standard. Moreover, it is preferable that the hardness of the tablet obtained is 2 kgf or more, More preferably, it is 4 kgf or more.
[0015]
【The invention's effect】
According to the present invention, in a method for producing a tablet by tableting a raw material powder mixture, it is possible to satisfactorily prevent caking and sticking without using anti-caking agents and lubricants such as silicon dioxide and sucrose fatty acid esters. It is possible to manufacture a tablet having a desired shape with a good appearance, a glossy surface and no irregularities. In addition, the raw material powder mixture has high fluidity, and can be smoothly filled with light. In addition, (A) producing a high-quality tablet that uniformly disperses and contains at least one selected from the group consisting of propolis, sugar, fruit juice powder, plant extract, and seasoning, has a good appearance, and has a predetermined hardness. be able to. Further, such tablets hardly discolor even after long-term storage.
EXAMPLES Hereinafter, although an Example is shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example.
[0016]
【Example】
Example 1
After 10 parts by mass of propolis powder was finely pulverized to a particle size of 355 μm or less (average particle size 100 μm) with a power mill, this was immediately mixed with 30 parts by mass of collagen having a particle size of 500 μm or less (average particle size 100 μm). The conditions for the preliminary mixing were 20% at a humidity of 45%, a temperature of 25 ° C., and 20 rpm. The premixed raw material powder, 59 parts by mass of starch having a particle size of 355 μm or less (average particle size of 100 μm) and 1 part by mass of rape hardened oil having a particle size of 600 μm or less (average particle size of 70 μm) are mixed and stirred so that each component is uniformly mixed A dispersed raw material powder mixture was prepared. The mixing conditions at this time were 45% humidity, a temperature of 25 ° C., and 20 rpm for 20 minutes.
This raw material powder mixture was filled into a tablet of a tableting machine (model HT-AP18SS2) manufactured by Hata Co., Ltd. and tableted. The tableting conditions at this time were a humidity of 45%, a temperature of 25 ° C., a rate of 720 pieces / minute, and a rate of 250 mg / piece.
The raw material powder mixture had high fluidity, and the filling into the tablet machine was smooth, and the powder could be compression molded well. In addition, no sticking occurred during the production, and it was possible to produce a tablet having a desired shape with a glossy surface and no irregularities. In addition, the intensity | strength of the obtained tablet was 12 kgf.
Each of the above tablets contains fine particles of propolis uniformly dispersed and has a good appearance, and the fine particles of propolis were hardly discolored after being stored in a sealed container for 12 months.

Claims (3)

(A) at least one raw material powder selected from the group consisting of propolis, sugar, fruit juice powder, plant extract and seasoning; and (B) at least one raw material selected from the group consisting of collagen, starch and dextrin Powder is mixed in a ratio of 10:50 to 10: 5 immediately after (A) raw powder is finely pulverized , and then mixed with (C) other raw powder for tableting. A tablet manufacturing method comprising preparing a raw material powder mixture and tableting the mixture.   (A) The manufacturing method according to claim 1, wherein the raw material powder is propolis.   (B) The production method according to claim 2, wherein the raw material powder is collagen.