WO2016000508A1

WO2016000508A1 - Chinese herbal medicine for treating gout and preparation method thereof

Info

Publication number: WO2016000508A1
Application number: PCT/CN2015/080663
Authority: WO
Inventors: 邹金林; 刘加才
Original assignee: 邹金林; 刘加才
Priority date: 2014-06-30
Filing date: 2015-06-03
Publication date: 2016-01-07
Also published as: CN104042893A

Abstract

Provided is a Chinese herbal medicine for treating gout, prepared from dried rehmannia, artificial tiger bone meal, aconitum carmichaelii, cudweed herb, complex calcium, Chinese yam, fructus corni, radix glehniae, ophiopogon japonicas, angelica, rhizoma alismatis, cortex moutan, poria, rhizoma dioscorea hypoglauca, liquorice, Cordyceps and amino sugar; further provided is a method of preparing the Chinese herbal medicine.

Description

Traditional Chinese medicine preparation for treating gout and preparation method thereof

Technical field

The invention discloses a traditional Chinese medicine preparation for treating gout, and provides a preparation method of the traditional Chinese medicine, belonging to the technical field of traditional Chinese medicine.

Background technique:

Gout is a disorder of sputum metabolism in the body. Excess sputum is oxidized to form uric acid, which can not be excreted by the kidneys through the urine, and then flows through the blood to the connective tissue and precipitates in the form of amino salt crystals. When there is an incentive. It will cause the release of uric acid crystals deposited in soft tissues and joint membranes, leading to sensitive reactions of the body's immune system, inflammation, and gout.

At present, there are many drugs and methods for treating gout. Such as: Chinese medicine decoction, Chinese patent medicine, Western medicine, tea dosage form and instrument treatment and other methods and medicines. However, the number of patients treated and newly discovered has not decreased, and it is increasing year by year!

According to clinical studies, the analysis suggests that the current dosage forms and methods have the following problems:

First, the lack of treatment from the source:

Existing drugs and methods neglect to enhance the body's antioxidant capacity and use interventional antioxidant effects to block and reduce strontium oxidation. Therefore, from the source, the problem of curing gout is slow and the treatment period is long.

Second, taking incorrect medications and methods can lead to drug-induced damage.

Because uric acid is fused in the blood, if it can neutralize uric acid in the blood, it is an effective measure to slow down and prevent uric acid deposition. Current western medicines such as colchicine have neutralized uric acid; but they bring great Drug-induced damage. Chinese medicine can also neutralize uric acid, but it has a slow effect and its effect is not significant. Only the use of fast, effective, safe and reliable acidic neutralizing agents will solve the problems of slow effect and ineffective efficacy.

Third, the current drugs and methods can not cure gout

Gout has the characteristics of long course of disease, repeated attacks, and difficulty in radical treatment. The current drugs and methods lack the concept foundation of “very sick and seven-pointed”, and it is not enough to simply take measures to improve immune function. Only the "self-healing rehabilitation system" function that stimulates the human body is the fundamental measure to fundamentally cure gout.

Fourth, the lack of overall comprehensive, systematic integration, coordination and reconciliation, taking into account the synchronization.

Gout involves diseases such as bones, nerves, blood circulation, urinary and endocrine, and affects organs such as heart, lung, liver, spleen and kidney. For example, gout can cause osteoporosis, complications can cause cardiovascular disease and cause kidney failure, sudden death, etc., simple protection is not enough. Some traditional Chinese medicines have the effect of dissolving uric acid crystals, but they cause an increase in the concentration of uric acid in the blood and affect the sudden onset of heart and kidney, posing a danger. Therefore, in protecting the heart and kidneys, there must be measures to save the sun and reversing. This is an important preventive measure.

Summary of the invention

The invention provides a traditional Chinese medicine preparation for treating gout, which is capable of inhibiting bismuth oxidation and inhibiting the activity of sputum synthesis reaction enzyme from the source, comprehensively comprehensive, systematically integrated, coordinated and unified, and taking the dissolution of urate crystallization and neutralization. The uric acid in the blood and the measures to prevent and treat the disease mutation; yin and yang complement the positive energy of the body and enhance the immune function of the body, and stimulate the body's own "self-healing rehabilitation system" ability. Thereby achieving a significant effect on the cure of gout.

The invention further discloses a preparation method of a traditional Chinese medicine preparation for treating gout, which is suitable for industrial production.

The invention provides a traditional Chinese medicine preparation for treating gout, which is characterized in that the following materials are prepared in parts by weight:

Dry Radix 12-14, artificial tiger bone powder 6-8, aconite 4-6, rat grass 12-14, complex calcium 30-40, yam 10-12, hawthorn meat 10-12, northern sand ginseng 8-10 Ke, Maidong 8-10, Angelica 10-12, Alisma 6-8, Danpi 6-8, 茯苓6-8, Chuantai 6-8, Licorice 6-8, Cordyceps 6-8, Aminoose 5- 7.

The preferred ratio of the traditional Chinese medicine preparation for treating gout according to the present invention is:

Dry Rehmannia 14, artificial tiger bone powder 8, aconite 6, koji grass 14, complex calcium 40, yam 12, hawthorn meat 12, northern sand ginseng 10 g, maidong 10, angelica 12, diarrhea 8, danpi 8 , 茯苓 8, Chuan Tai 8, licorice 8, Cordyceps 8, ammonia sugar 7.

The preparation method of the traditional Chinese medicine preparation for treating gout according to the present invention comprises the following steps:

Weigh the above raw materials proportionately; select dried radix, aconite, rat grass, yam, hawthorn meat, northern sand ginseng, yam, angelica, diarrhea, paeonol, medlar, chuantai, licorice, cordyceps, After the impurities are mixed and pulverized, they are passed through a 60-100 mesh sieve, and 10 times by weight of 40-60 degree white spirits are added, and immersed for 72-96 hours under intermittent stirring and normal temperature; the impregnated liquid is thoroughly filtered to remove the dregs; The slag-removed liquid is placed in a container, and the alcohol is extracted at a temperature of 50-60 ° C and agitation. When the specific gravity of the alcohol liquid reaches 0.95 Baume, the alcohol is stopped when the weight of the alcohol liquid reaches 50% of the weight of the liquor; The liquid after the alcohol extraction is dehydrated and concentrated at a temperature of 70-80 ° C and evacuated, and the water gas is cooled and formed into a liquid and then received by the container. When the specific gravity of the receiving water reaches 1.0 Bamei and the weight reaches 30% of the weight of the liquor, Stop dehydration and concentration, cool to normal temperature, that is, the effect concentrate; the concentrated effect concentrate, fully mixed with artificial tiger bone powder, ammonia sugar, complex calcium.

[Usage and Dosage] Oral; early and early patients: morning and evening, 600mg each time. Middle and advanced patients: 1200mg each time in the morning and evening.

[Adapt to the population] Patients with early, early, middle and late stages of gout.

According to the clinical analysis of the present invention, the active ingredient in the rat grass, the yellow phenol, dissolves the urate crystal, and the blood The liquid is circulated back into the blood. According to this feature, complex calcium is used as a uric acid neutralizing agent to neutralize uric acid in the blood and neutralize the acidic environment of the body to form an acid-base equilibrium state; the dissolution and neutralization integrity is achieved.

When the urate crystals are dissolved, the uric acid in the blood is increased. In order to prevent the occurrence of coronary heart disease, diabetes, hypertension, and renal failure complications, the active ingredients of aconite are used to prevent sudden changes in the disease and various natural Chinese herbal medicines for protecting heart, liver, spleen, lung and kidney function are used to strengthen the body. masculinity. Prevent and alleviate the occurrence of complications.

Because the morbidity causes great energy loss to the body, it is necessary to supplement a large amount of nutrients while enhancing the function of the body. The materials of the prescription contain polysaccharides, amino acids, vitamins, trace elements, etc., to supplement the consumption needs. Yin tonic. The yin and yang complement each other, which improves the positive energy of the body.

Therefore, only Yin and Yang can make a comprehensive cure for gout, which solves the problem of the slow effect and drug-induced harm caused by current methods and drugs.

The use of aconite in the group of the invention is an effective scientific method adopted according to the pathological characteristics of gout. The use of complexed calcium to neutralize uric acid is also a unique novelty of the present invention.

The invention strengthens the function of the spleen and stomach, enhances the absorption, utilization and transportation ability of the active ingredients; enhances the function of the endocrine system and the urinary system and improves the metabolic capacity of the body; and repairs the bone joint and the cartilage tissue by using the artificial bone bone, the bone and the bone to repair the bone and joint and the cartilage tissue. Osteoporosis caused by decalcification of the skeletal system with complex calcium and bone. Improve lung function by raising lungs and lungs, and increase the amount of blood circulation. Strong heart, solid kidney, liver protection to prevent sudden changes in the disease; systematic comprehensive treatment of gout, to solve the problems of the current methods and drugs, such as slow effect, long treatment period. According to the occurrence of disease mutation or neutralization of uric acid is not enough, so we adjust the proportion, increase the amount of complexed calcium, and achieve the principle of combining actual and actual conditions, achieving the coordination of dissolution, neutralization and body system capabilities. . It solves the problem that the current methods and drugs are slow, the treatment is not comprehensive, and it is difficult to cure the problem. In the process of curing gout, not only must we take into account the synchronization of dissolution and neutralization, but also simultaneously inhibit the synthesis reaction of sputum in the liver and enhance the antioxidant activity of the body. This technique of curing gout from the source is currently unique and incomparable in the treatment of gout.

The invention also has the advantages that the repair and the treatment are synchronized; the bone joint cells and the cartilage tissue cells are repaired simultaneously, and the hyperplastic bone synovial fluid is synchronously reduced to reduce the pain and the wear of the bone joints.

The outstanding advantage of the invention is that: according to the principle of "very sick and seven-point raising" of the motherland medicine, while improving the immune function, a relatively large amount of complex calcium is used to synchronously enhance the body's own "self-healing rehabilitation system" ability; The strong feature of rehabilitation is the advantage of the inventiveness and novelty of the present invention.

To sum up: the invention is under the guidance of the new concept of treatment, prevention, repair and nourishment. The compatibility of the prescriptions is scientific, the nutrition elements are reasonable, and the technology is reasonable and feasible. The source of the treatment is comprehensive, comprehensive and repaired. A new type of product structure that does not dry the yang, does not greasy, nourish and maintain the viscera, and the body system; from the source to the whole to cure the pain The recurrence of wind disease is reflected in the remarkable effect of quick effect, short treatment period and fast healing. The traditional Chinese medicine materials used: pure natural, strong affinity, safe and reliable.

The invention solves the problem: the anti-oxidation, the dissolution of urate crystals, the combination of uric acid in the blood of the combination; the swelling, analgesia; the combination of internal treatment and external treatment; treatment and prevention of sudden onset of complication Combination; combination of Peiyang and Bu Yin; combination of treatment and repair; method and method of combining immune function and enhancing the body's own self-healing rehabilitation system: comprehensive, systematic, coordinated, and synchronized The principle is the only, scientific, reliable, correct, and dialectical method of curing gout.

In the prescription: dry rehmannia: has a strong heart, blood pressure, blood sugar lowering effect. Dry rehmannia has the effect of improving, improving kidney function and reducing mortality. Dry rehmannia has anti-inflammatory and antibacterial effects on acute inflammation. It has a calming effect and increases sleep to alleviate pain. Dry rehmannia can promote the transformation of lymphoblasts in the body to increase the number of T lymphocytes and enhance the function of phagocytic cells, especially for those with low immune function. Aconite: It has a good cardiotonic effect; it has the effect of supplementing the fire and helping the yang, so that the kidney failure can be restored to the yang to prevent the occurrence of uremia and relieve the dangerous situation. Gout is a form of gouty arthritis. The motherland medicine believes that wind and cold are inflammation. Aconite has the function of dispelling cold and hurricane, and treats the symptoms of wind, cold and dampness, and can treat bone and joint deformation caused by gout. The effect of Fuzi Huiyang on rescuing, anti-inflammatory and analgesic is incomparable with any medicine. This is the purpose of using aconite in the square. The poison of the aconite is removed by the licorice. The morphine is rich in flavonoids and luteolin, which dissolves the urate crystals deposited on the joints and cartilage tissue and gently returns to the blood, neutralizing it in the blood. The rat grass contains flavonoids, which have blood circulation, lower blood fat, lower blood viscosity, eliminate fat deposition on the blood vessel wall, and remove urate scale in the kidney, so that the kidney is in a clean state. It also has a firm and repairing effect on bones and joints. The calcium carbonate is enzymatically hydrolyzed, and the formed complex calcium is easily absorbed and utilized by the human body. Calcium deficiency not only causes bone diseases, but also causes diseases in all aspects of the body. The use of complexed calcium to neutralize uric acid and cure gout is the fundamental effect of quick effect and remarkable curative effect. It is a coordinated and unified scientific method of safety and no side effects.

In summary: the use of dry radix rehmannia, comprehensive conditioning and the use of artificial tiger bone powder to quickly reduce swelling, analgesia, systemic comprehensive repair damage to the joints, synovium; use aconite to return to the sun to prevent or relieve due to gout The sudden harm caused by the complication caused by the disease; the morphine crystals are dissolved in the morphine grass, and the blood circulation is promoted, the blood flow is removed to remove the scale of the kidney and the dirt on the wall of the large blood vessel; It neutralizes the acidic substances in the blood and the body, balances the acidity and alkalinity of the body, and treats osteoporosis. According to the pathology of gout, the symptoms and its harmful characteristics, the above five materials have achieved the remarkable effect of curing gout with the overall comprehensiveness and taking into account the simultaneous effects. Therefore, the five-flavored material is used as a drug.

嘌呤 is present in the blood in the form of ruthenium nucleotide crystals and is a fat-soluble substance having the formula: C ₅ H ₄ N ₄ . After being lipidated, it becomes a liquid and exists in the blood. It is oxidized to form uric acid with the molecular formula: C ₅ H ₄ N ₄ O ₃ . In fact, it is a nitrogen-based heterocyclic organic substance having a molecular formula of C ₅ (HN) ₄ O ₃ . Therefore, the purine nucleotide is oxidized and then converted from a liquid state to a solid crystal having an amino group, which is deposited in the blood, and is hindered during blood circulation (such as joints, soft tissues, etc.). According to the analysis of the above mechanism characteristics, if the body's antioxidant capacity is enhanced and the blood triglyceride and cholesterol levels are lowered and the blood viscosity is lowered, it is one of the keys to curing gout from the source. In the prescription, Angelica: blood, nourishing blood, enhance blood circulation, accelerate the dissolution of acid and excretion, the analgesic effect is significant, with free radical scavenging, anti-lipid peroxidation and inhibition of oxidation; yam: spleen, It has a significant effect on nourishing the lungs and solidifying the kidneys, promoting blood circulation and accelerating the synthesis of uric acid and metabolism. At the same time, it has better immunomodulatory effects and anti-hypoxia effects. Hawthorn meat: It has better immune function; lowers blood sugar, improves the survival rate of cardiomyocytes, and prevents the occurrence of coronary heart disease and diabetes caused by gout. At the same time, it has anti-oxidation effect and liver blood to prevent viral damage. Northern sand ginseng relieves arteriosclerosis and anti-oxidation of lipids. The above four flavor materials not only have anti-inflammatory, analgesic, anti-inflammatory, coronary heart disease, diabetes and immune function, but also have anti-hypoxia and anti-oxidation effects. It reduces the significant effect of strontium oxidation. It has achieved the effect of curing gout from the source. In conjunction with the drug, it has a unique effect, so it is a drug.

The liver is an important organ for synthesizing sputum from the head. The synthetic site is in the cytosol, and the desired substance is phosphoribosose. Glutamine and the like. The hydrazine is synthesized step by step on the basis of phosphoribosoid molecules, and the key enzyme of the synthesis reaction is transfer synthetase.

Studies have shown that: inhibiting and reducing the activity and quantity of metastasis synthase; controlling the synthesis of the reaction medium and increasing the function of various amino acids in the liver to synthesize proteins, inhibiting and reducing the substance requirements of the sputum synthesis reaction, which is also the source of gout One of the important measures.

In the prescription, Maidong: nourishing Yinshengjin, moistening the lungs and clearing the heart, has the ability to improve hypoxia tolerance, reduce the incidence of arrhythmia, protect myocardial ischemia, improve cardiac hemodynamic effects, increase myocardial energy supply, and limit the scope of myocardial infarction. The flavonoids in the active constituents of Monroca sinensis have an activity of inhibiting the activity of sputum and phosphoribose synthesizing enzymes. The drug Angelica contains 12 kinds of amino acids needed by the human body, and also protects the liver from damage. The effect of promoting blood circulation and removing blood stasis is remarkable. Maidong nourish the stomach and nourish the heart, and the mucus contained in it provides the raw material for the restoration of liver cell membrane. Ophiopogon japonicus and medicinal herbs have good results. As a medicine for Sasuke. The motherland medicine believes that: "The kidney is the congenital basis" and "the root of life" "the internal organs of the five internal organs and the yang are all warm in the kidney, and the yin of the internal organs have nourishing the kidney." It can be seen how important the kidney is in the health and life of the body.

Because uric acid is excreted from the urine by the kidneys, the concentration of uric acid is constantly increasing, so that the ability of renal function cannot meet the needs of excretion. Therefore, excess uric acid crystals are deposited in the kidney, and long-term accumulation may cause uremia caused by renal failure. People die. Therefore, in the treatment of gout, it is necessary to protect the kidney, strengthen the kidney, and nourish the kidney to strengthen the excretory function of the kidney.

In the prescription: Cordyceps: Yishen Qingfei, tonic bone marrow, Guben Fuzheng. The effective ingredient of aconite in the medicine, warm kidney Yang, Huiyang rescue; the effective ingredients in dry rehmannia, yam, hawthorn meat nourish kidney yin, yin and yang complement, on the one hand provide sufficient nutrients, on the one hand enhance kidney function, reach the kidney, Significant effect of solidifying kidney and nourishing kidney. Cordyceps sinensis is used as an auxiliary medicine. Enhancing the uric acid excretion ability after sputum and oxidation is one of the important measures to cure gout.

In the prescription: Alisma: treatment of gonorrhea hematuria and significant diuretic effect. Danpi: inhibits enzyme protein-induced damage and good diuretic effects.茯苓: Significant diuretic effect on immune function in renal and cardiac patients. Has: anti-cirrhosis effect. Has: improve gastrointestinal function and anti-ulcer effect. Chuan Tai: Huoxue Tongjing, Qufeng Dehumidification, Tongli Joint, Diuretic Tonglin, significantly reduced the incidence of serum cholesterol and aortic atherosclerosis. The active ingredients in the above four flavor materials are coordinated with each other to achieve a significant effect of nourishing the kidney and strengthening the yang, nourishing yin deficiency, strengthening the heart, protecting the liver, and strengthening the spleen and stomach transportation and metabolism. Fang Zhongze Xie, Danpi, Sui and Chuan are all medicines for Sasuke.

Improving the body's own immune function and resisting external invasion are important measures for treating diseases. It is also a powerful measure to cure gout.

Strengthening the ability of “self-healing rehabilitation system” is an important and important measure to cure gout.

On the basis of improving the immune function, the ability to enhance the "self-healing rehabilitation system" and the combination of treatment and rehabilitation will achieve a significant effect on the cure of gout.

In the prescription: the active ingredient in the drug, the drug, has a significant increase in T lymphocytes in the peripheral blood, and promotes the production of antibodies - hemolysis. The active ingredients in yam have the following factors: increasing lymphocyte transformation rate and promoting production of serum hemolysin. The active ingredient polysaccharide in the hawthorn meat has obvious immune promoting effect; it can activate natural killing and macrophage system activity. Enhancement of mononuclear-phagocytic cells by the active constituents of Radix. The active ingredient in Angelica has a significant activation effect on the phagocytic system, and has immunomodulatory and immune-recovering effects on the immunocompromised.

In summary, the monarch, minister, and adjuvant in the prescription have a significant effect on improving immune function.

The body's own "self-healing rehabilitation system" is composed of a combination of a skeletal system, a meridian system, and a nervous system. Its role is to play a self-healing effect in the treatment of the disease and in the rehabilitation after treatment. Therefore, the cure of gout and the ability to enhance the "self-healing rehabilitation system" is a crucial measure and a key means to solve the problem of gout without recurrence.

The self-healing rehabilitation system is inseparable from the participation of calcium. Otherwise, the "self-healing rehabilitation system" is difficult to play! The reason is: calcium is the main component of the skeletal system; it is the second messenger of the meridian system; it is also the transmitter of the nervous system that transmits information. The addition of a large amount of complex calcium in the prescription is to neutralize the uric acid in the blood and to repair and activate the systemic capacity of the "self-healing rehabilitation system" due to decalcification. In this way, the purpose of quick recovery and radical cure can be achieved.

Long-term suffering from gout, due to the deposition of urate in bone and joint and cartilage tissue, leading to abnormal metabolism of bone and joint cartilage cells, it will also cause the production of cartilage tissue proteoglycan in bone and joint - glucosamine self Synthetic ability, self-secretion ability, and resistance to oxidation reaction decrease, causing the loss of the source of cartilage synovial fluid and causing giant pain, resulting in joint and soft tissue damage and severe deformation.

Therefore, repairing the damage of bone and joint, cartilage tissue, strengthening cell metabolism, and enhancing the secretion of synovial fluid are indispensable measures to cure gout.

In the group: Glucosamine is a pure natural substance extracted from marine organisms. It has the remarkable effect of activating cartilage connective tissue cells, cartilage tissue cells, synthetic polysaccharides and collagen fibers to form cartilage matrix, repairing bone and joint cartilage tissue, and promoting joint synovial fluid. The characteristics and effects of glycosaminoglycan are indispensable for restoring the normal physiological state of bone and joint and cartilage tissue during the treatment of gout. Licorice: Replenishing spleen and replenishing qi, clearing away heat and detoxifying, reconciling various drug functions. In addition to clearing heat and detoxification, the licorice is mainly used for reconciling various medicines, so that the prescription becomes a non-toxic and hormone-free product. Into the heart, liver, spleen, stomach, lungs, kidneys can be used as medicine to walk through the medicine.

The positive effects of the present invention are:

From the overall comprehensive, systematic synthesis, coordination, and synchronization, from the source to inhibit the oxidation of ruthenium, inhibit the activity of ruthenium synthesis reaction enzymes, dissolved urate crystals, neutralize uric acid in the blood and prevent and cure disease mutations, etc. Measures; Yin and Yang complement to improve the body's positive energy and enhance the body's immune function, and stimulate the body's own "self-healing rehabilitation system" ability. Thereby achieving a significant effect on the cure of gout. The group is based on pure natural, safe and reliable, scientific compatibility, reasonable combination of nutrients and materials; adopts a scientific, accurate and dialectical, novel and unique method of overall comprehensive, systematic synthesis, coordination and synchronization, and a comprehensive and unique method. Gout, improve immune function and enhance the body's self-healing rehabilitation.

The clinical effects of the medicament of the present invention are shown by the following tests:

First, the diagnostic criteria:

According to the "Diagnosis of Modern Chinese Medicine", gout is the clinical diagnostic criteria.

gout:

It is characterized by: weak waist and knees, sore bones, severe pain in the toes, redness, limited mobility, difficulty in self-care, and consequent low immune function, insomnia, and fatigue. Urine test: uric acid concentration is seriously exceeded.

Second, the inclusion criteria:

All the above signs can be included in the standard.

Third, the method of taking:

Early and early patients: oral, twice daily, morning and evening. 600mg each time. Or follow the doctor's advice.

Middle and advanced patients: oral, twice daily, morning and evening. 1200mg each time. Or follow the doctor's advice.

Fourth, the efficacy judgment standard:

Signs according to the diagnostic criteria: a course of treatment for 20 days, a total of three courses.

Cure: After taking 2-3 courses of treatment, there is no recurrence in one year, and the uric acid value is normal, the joint deformation is restored, and the life is completely self-care.

Significant effect: After taking 1-3 courses of treatment, there are obvious relief or elimination of symptoms of more than 70%, life can be self-care, joint deformation is generally restored, and the recurrence phenomenon is basically not obvious.

Effective: After taking 1-3 courses, it can relieve or eliminate symptoms by more than 50%, life is basically self-care, and joint deformation begins to recover.

Invalid: no mitigation or no symptoms after taking 1-3 courses of treatment.

V. Clinical results statistics:

Only 86 patients with gout were admitted within one year.

Among them: 25 patients in the early and early stages. Among them, 2 courses cured 23 people. 3 courses were cured for 2 people. There were 61 patients in the middle and late stages. Three of these treatments cured 53 people. After 3 courses of treatment, 8 people were effective. No invalid data is displayed.

The percentage statistics are as follows:

Early and early: efficient: 100%; significant efficiency: cure rate: 100%;

Middle and late: effective rate: 100%; significant efficiency: 13%; cure rate: 87%;

Total effective rate: 100%; total effective rate: 9%; total cure rate: 91%. No invalid data is displayed.

detailed description

The following examples are presented to facilitate the understanding of the invention, and are intended to be illustrative of the invention and not to limit the invention.

Example 1

Weighed 14 grams of dry earth yellow, 6 grams of aconite, 14 grams of rat grass, 12 grams of yam, 12 grams of hawthorn meat, 10 grams of northern sand ginseng, 10 grams of wheat winter, 12 grams of angelica, 8 grams of Alisma, Danpi 8克, 茯苓8g, Chuantai 8g, licorice 8g, Cordyceps 8g to impurities, mixed and crushed, all passed 60-100 mesh sieve, add 10 times the weight of 50 ° liquor, impregnated under intermittent stirring and normal temperature 96 hours; the impregnated liquid is thoroughly filtered to remove the dregs; the liquid after the slag is placed in a container, the alcohol is extracted at a temperature of 50-60 ° C and stirred, and when the specific gravity of the alcohol liquid reaches 0.95 Baume, the received When the weight of the alcohol liquid reaches 50% of the weight of the liquor, the alcohol is stopped; the liquid after the alcohol extraction is dehydrated and concentrated at a temperature of 70 ° C and evacuated; when the specific gravity of the receiving water reaches 1.0 Baume and the weight reaches 30% of the weight of the liquor. Stop dehydration and concentration, and cool to normal temperature, that is, the effect concentrate; the concentrated effect concentrate, 8 grams of artificial tiger bone powder, 7 grams of ammonia sugar, 40 grams of complex calcium, fully mixed and obtained.

Example 2

Weigh 13 grams of dry earth yellow, 5 grams of aconite, 13 grams of rat grass, 11 grams of yam, 11 grams of hawthorn meat, 9 grams of northern sand ginseng, 9 grams of wheat winter, 11 grams of angelica, 7 grams of Alisma, and 7克, 茯苓7g, Chuantai 7g, licorice 7g, Cordyceps 7g to impurities, mixed and crushed, all passed 60-100 mesh sieve, add 10 times weight of 50 ° liquor, impregnated under intermittent stirring and normal temperature 80 hours; the impregnated liquid is thoroughly filtered to remove the dregs; the liquid after the slag is placed in a container, and the alcohol is extracted at a temperature of 55 ° C and agitation, and the alcohol liquid is received when the specific gravity of the alcohol liquid reaches 0.95 Baume. When the weight reaches 45% of the weight of the liquor, the alcohol is stopped; the liquid after the alcohol is dehydrated and concentrated at a temperature of 75 ° C and evacuated; when the specific gravity of the receiving water reaches 1.0 Baume and the weight reaches 25% of the weight of the liquor, the suspension is stopped. Dehydrated and concentrated, cooled to normal temperature, that is, the effect concentrate; the concentrated effect concentrate, 7 grams of artificial tiger bone powder, 7 grams of ammonia sugar, 35 grams of complex calcium, fully mixed and obtained.

Example 3

Weighed 12 grams of dry earth yellow, 4 grams of aconite, 12 grams of rat grass, 10 grams of yam, 10 grams of hawthorn meat, 8 grams of northern sand ginseng, 8 grams of wheat winter, 10 grams of angelica, 6 grams of Alisma, and Danpi 6 6 grams of gram, 6 grams, 6 grams of Chuantai, 6 grams of licorice, 6 grams of Cordyceps, mixed with impurities, all passed 60-100 mesh sieve, added 10 times weight of 50 ° liquor, impregnated under intermittent stirring and normal temperature 72 hours; the impregnated liquid is thoroughly filtered to remove the dregs; the liquid after the slag is placed in a container, the alcohol is extracted at a temperature of 50-60 ° C and stirred, and when the specific gravity of the alcohol liquid reaches 0.95 Baume, the received When the weight of the alcohol liquid reaches 50% of the weight of the liquor, the alcohol is stopped; the liquid after the alcohol extraction is dehydrated and concentrated at a temperature of 70 ° C and evacuated; when the specific gravity of the receiving water reaches 1.0 Baume and the weight reaches 30% of the weight of the liquor. Stop dehydration concentration, cool to normal temperature, that is, the effect concentrate; concentrate the concentrated effect, with artificial tiger bone powder 6 grams, 5 grams of ammonia sugar, 30 grams of complex calcium, fully mixed and obtained.

The significant efficacy of the agents of the invention is further illustrated by the following typical cases:

Case 1:

Zeng X, male, 42 years old. Chief Complaint: Gout has been attacked for three days. This year is the third time. I have to go to the hospital for an injection and take medicine for one or two months. I have repeatedly been ill. Has a medical history for three years. Physical examination: pulse Hong, red tongue, thick moss. Urine test: uric acid value (UA693umoI/L) is seriously exceeded, blood pressure: 146/82hgmm, redness and swelling of the lower extremity ankle, severe pain, heat. Diagnosis: mid-term of gout. Treatment: The preparation of Example 1 of the present invention was administered for 2-3 courses. Oral: twice daily, morning and evening, each time 1200mg (two). Recommendation: Eat more alkaline foods. Bogey: beer. Follow-up after one year: it has healed. Immune function has been enhanced.

Case 2:

Zhao XX, male, 53 years old. Chief Complaint: Gout has been attacked for 5 days. This year is the third time. The medical history has been 4 years, and the long-term doctor has not cured. Have a history of hypertension. Physical examination: pulse Hong, heart palpitations, red tongue, thick and sticky moss, urine test: uric acid value (UA769um0I/L) is seriously exceeded. Toe, tibia joint red, swelling, pain, heat. Diagnosis: middle and late gout. Treatment: Take the 2-3 course of the preparation of the embodiment 2 of the invention, orally: twice daily, morning and evening, each time 1200mg (two tablets), stop taking other drugs. Follow the course of treatment. Follow-up after one year: it has healed. No recurrence in one year.

Case 3

Yang XX, female, 61 years old. Oral: Gout has been eight years old, 3-4 times a year, once more than one time, long-term treatment is invalid. The whole body is weak. Physical examination: pulse Hong, thick red tongue, urine test: uric acid value (UA586um0I / L) was seriously exceeded. Blood pressure: 178/90hgmm, high blood lipids. Toe joints, finger joints are red, swollen, painful, and deformed. Diagnosis: middle and late gout. Treatment: The procedure of Example 3 of the present invention was administered for 3 courses. Oral: twice daily, morning and evening, each time 1200mg (two). Follow-up after one year: It has healed, no recurrence, joint deformation has basically recovered, and the spirit is good.

Claims

A traditional Chinese medicine preparation for treating gout, which is characterized in that the following raw materials are prepared in parts by weight:

Dry Radix 12-14, artificial tiger bone powder 6-8, aconite 4-6, rat grass 12-14, complex calcium 30-40, yam 10-12, hawthorn meat 10-12, northern sand ginseng 8-10 Ke, Maidong 8-10, Angelica 10-12, Alisma 6-8, Danpi 6-8, 茯苓6-8, Chuantai 6-8, Licorice 6-8, Cordyceps 6-8, Aminoose 5- 7.
The traditional Chinese medicine preparation for treating gout according to claim 1, wherein the preferred ratio is:

Dry Rehmannia 14, artificial tiger bone powder 8, aconite 6, koji grass 14, complex calcium 40, yam 12, hawthorn meat 12, northern sand ginseng 10 g, maidong 10, angelica 12, diarrhea 8, danpi 8 , 茯苓 8, Chuan Tai 8, licorice 8, Cordyceps 8, ammonia sugar 7.
A method for preparing a traditional Chinese medicine preparation for treating gout according to claim 1 or 2, comprising the steps of:

Weigh the above raw materials proportionately; select dried radix, aconite, rat grass, yam, hawthorn meat, northern sand ginseng, yam, angelica, diarrhea, paeonol, medlar, chuantai, licorice, cordyceps, After the impurities are mixed and pulverized, they are passed through a 60-100 mesh sieve, and 10 times by weight of 40-60 degree white spirits are added, and immersed for 72-96 hours under intermittent stirring and normal temperature; the impregnated liquid is thoroughly filtered to remove the dregs; The slag-removed liquid is placed in a container, and the alcohol is extracted at a temperature of 50-60 ° C and agitation. When the specific gravity of the alcohol liquid reaches 0.95 Baume, the weight of the alcohol liquid received reaches 45-50% of the weight of the liquor. Alcohol; dehydrating and concentrating the liquid after alcohol extraction at a temperature of 70-80 ° C and evacuating; when the specific gravity of the receiving water reaches 1.0 Baume and the weight reaches 25-30% of the weight of the liquor, the dehydration concentration is stopped, and the temperature is cooled to room temperature. , the effect concentrate; the concentrated concentrate after the effect, and artificial tiger bone powder, ammonia sugar, complex calcium fully mixed and obtained.