CN106924710B - A kind of Chinese medicine preparation and preparation method thereof of inside and outside two-way treatment gout - Google Patents

A kind of Chinese medicine preparation and preparation method thereof of inside and outside two-way treatment gout Download PDF

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CN106924710B
CN106924710B CN201710345883.3A CN201710345883A CN106924710B CN 106924710 B CN106924710 B CN 106924710B CN 201710345883 A CN201710345883 A CN 201710345883A CN 106924710 B CN106924710 B CN 106924710B
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chrysophanol
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邹金林
刘加才
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Abstract

The present invention relates to a kind of Chinese medicine preparations and preparation method thereof of inside and outside two-way treatment gout, it is made of oral preparations and externally applied formulation, wherein oral preparations by 5 ~ 10 parts of leech, 10 ~ 15 parts of lotus nut, 10 ~ 15 parts of Radix Angelicae Sinensis, 10 ~ 15 parts of matrimony vine, etc. be made, external application paste is made of 10 ~ 15 parts of lopseed, 10 ~ 15 parts of semen momordicae, 3 ~ 5 parts of Chrysophanol, 20 ~ 30 parts of dog bone glue.The present invention is applied with using the lytic agent of dissolving lithate, is coordinated dissolving for oral administration and is neutralized the uric acid in blood, to inside and outside two-way treatment gout, clinical effectiveness is apparent, and curative effect is reliable.

Description

A kind of Chinese medicine preparation and preparation method thereof of inside and outside two-way treatment gout
Technical field：
The invention belongs to Chinese medicine pharmaceutical technology fields, and in particular to a kind of Chinese medicine preparation of inside and outside two-way treatment gout and Preparation method.
Background technology：
Gout is by monosodium urate salt（MSU）Deposition caused by crystal correlation arthropathy, with purine metabolic disturbance and （Or）Hyperuricemia caused by underexcretion is directly related, refers in particular to acute characteristic arthritis and chronic gout stone disease Disease includes mainly acute attack arthritis, tophus formation, tophaceous chornic arthritis, urate nephropathy and uric acid Lithangiuria, severe one may occur in which joint deformity and renal insufficiency.Gout has been included in the row of four height due to uric acid height by people, As difficult to treat, high recurrence rate different difficult illness, and due to there is presently no good, effective therapy, incidence and Newborn patient is increasing year by year.Currently, suffer from the crowd of gout, it is largely the people of serious crisis between 40-50 Sui Health and affect working efficiency.Gout has aroused great concern, also difficult to treat at medical matters circle The different difficult disease problem that needs to capture at medical worker.
The hot rheumatism of gout Chinese medicine appellation.So motherland's medicine thinks in therapy：" all sufferings sores all belong to the heart, all Wet turgor all belongs to spleen." so, it uses：Akebi（It is cold in nature sweet in flavor）Clearing away the heart-fire；Lotus nut（Bitter cold in nature）It is depressured the smooth rhythm of the heart, town It is quiet；Leech：（It is mild-natured, the salty hardship of taste）It purifies the blood, dissipates the stasis of blood.Radix Angelicae Sinensis：（It is warm-natured, sweet in flavor）, promoting circulation of blood, blood-nourishing, enhancing blood circulation；Reinforce blood Liquid recycles, and it is to treat the important measures of gout to improve metabolic capability.Above four taste have clearing away the heart-fire, purify the blood, promoting circulation of blood, blood-nourishing, Then stasis of blood effect strengthens the metaboilic level of uric acid and purine.Using honeysuckle（Cold in nature, taste micro-sweet）With heat-clearing, detoxication. American Ginseng（It is micro- cool, sweet in flavor）With visible subsidy gas, heat-clearing, detoxication.
It is had the following problems in therapy at present：One is a lack of a kind of effective ways of neutralizing urate crystal. Secondly being a lack of a kind of middle method for closing uric acid constantly thorough in blood.Damaged joints sclerotin is thoroughly repaired thirdly being a lack of Effective material and method.Also, on the one hand want the function of the comprehensive adjustment body vital organs of the human body flat during treating gout On the one hand weighing apparatus will also improve the immune function of itself, treatment gout can just obtain good effect under such medical principle Fruit.
Therefore, there is still a need for exploitation can effectively treat gout and toxic side effect is small, is not easy the drug of recurrence.
Invention content：
To solve technical barrier in the prior art, the present invention provides the Chinese medicine preparation for the treatment of gout, principle is It is applied with using the lytic agent of dissolving lithate, coordinates dissolving for oral administration and neutralizes the uric acid in blood, to inside and outside two-way treatment Gout, Chinese medicine preparation clinical effectiveness of the invention is apparent, and curative effect is reliable.
The present invention is that the goal of the invention of the present invention is realized by technical solution below.
On the one hand, the present invention provides a kind of Chinese medicine preparations of inside and outside two-way treatment gout, by oral preparations and outside Preparation composition is applied, wherein：
Oral preparations are made by ratio of weight and the number of copies of following raw material：5 ~ 10 parts of leech, 10 ~ 15 parts of lotus nut, Radix Angelicae Sinensis 10 ~ 15 Part, 10 ~ 15 parts of matrimony vine, 10 ~ 15 parts of akebi, 20 ~ 30 parts of Chinese yam, 20 ~ 30 parts of walnut kernel, 3 ~ 5 parts of Chrysophanol, biological calcium carbonate 5 ~ 10 parts, 3 ~ 5 parts of egg-shell meal, 10 ~ 15 parts of honeysuckle, 10 ~ 15 parts of the root of straight ladybell, 10 ~ 15 parts of ramulus mori, 3 ~ 5 parts of monkshood, 10 ~ 15 parts of Radix Glycyrrhizae, First 5 ~ 10 parts of milk basic protein, 5 ~ 10 parts of cordyceps sinensis；
External application paste is made by ratio of weight and the number of copies of following raw material：10 ~ 15 parts of lopseed, 10 ~ 15 parts of semen momordicae, Chrysophanol 3 ~ 5 parts, 20 ~ 30 parts of dog bone glue.
Preferably, oral preparations are made by ratio of weight and the number of copies of following raw material：10 parts of leech, 15 parts of lotus nut, Radix Angelicae Sinensis 14 Part, 15 parts of matrimony vine, 15 parts of akebi, 30 parts of Chinese yam, 30 parts of walnut kernel, 5 parts of Chrysophanol, 10 parts of biological calcium carbonate, 5 parts of egg-shell meal, 15 parts of honeysuckle, 15 parts of the root of straight ladybell, 15 parts of ramulus mori, 5 parts of monkshood, 15 parts of Radix Glycyrrhizae, 10 parts of first milk basic protein, 10 parts of cordyceps sinensis；It is applied with Paste is made by ratio of weight and the number of copies of following raw material：15 parts of lopseed, 15 parts of semen momordicae, 5 parts of Chrysophanol, 30 parts of dog bone glue.
Clinic confirms the key for treating gout is how to dissolve the urate crystal being deposited on joint.Due to gout Uric acid concentration in disease blood samples of patients is excessively high, and when blood circulation downlink can be deposited on Bones and joints, especially anklebone joint, deposition After become urate crystal, with blood circulation can thicken area increase, a part can be dissolved in treatment, has one on original surface Fixed alleviation, and understand recurrent exerbation actually uric acid crystal is all dissolved, after encountering external cause, here it is gout hardly possiblies With the place of healing, therefore, it is the important prerequisite for curing gout thoroughly to dissolve urate crystal.Further confirm：It is deposited on After lithate on joint is dissolved, enter blood circulation state in the form of uric acid liquid, the pH value of blood is made to become acidity. The present invention is using mixture in alkalinity, and effective middle conjunction uric acid, is greatly lowered the uric acid concentration in blood, conforms to people in blood The transporting rule of body acid-base balance is that treatment gout is positive, effective scientific method.Thought according to clinical observation repeatedly： Currently, the key that cannot cure gout is cannot thoroughly to dissolve and eliminate the urate crystal being deposited on Bones and joints, it cannot Thoroughly the middle uric acid that closes reduces uric acid concentration in blood.
It is also demonstrated in clinic：After lithate dissolves, the state of an illness is will produce since uric acid increases into blood circulation process Mutation, to prevent and inhibiting sudden lesion, this invention takes clearing away the heart-fire, Pi benefit stomaches are good in sharp lung liver protection, and it is comprehensive that state's kidney supports kidney etc. Conditioning is closed, the effective measures of viscera function are improved and recuperating depleted yang, strengthens the body resistance to consolidate the constitution, is anti-oxidant, improving and exempt from the auxiliary treatment of function Method has effectively coordinated the treatment of gout, benefit to achieve remarkable result.In addition, being repaiied using a kind of strength of external invention The fine first milk basic protein of crisp new material-of multiple bone, has played when treating gout and has repaired being destroyed by uric acid salt corrosion Osteocyte special role and remarkable result.
Gout is lacked of proper care by what purine metabolism, and superfluous purine generates uric acid by oxidation, and is deposited on blood circulation Bones and joints form urate crystal, go out to fold from membrana articulata under inducement effect, keep periarticular red, swollen, urate crystal Locate Bones and joints pain unbearably.So treatment gout key is dissolving and eliminates the urate crystal on Bones and joints, morbidity disease is eliminated Stove is the first step measure for treating gout mole.Chrysophanol is used in innerwear Chinese medicine preparation of the present invention and is dissolved by blood circulation urinates Hydrochlorate crystallizes, while also dissolving urate crystal using outer coating method, in the present invention the source of used raw material and effect It is as follows：
Leech：For Hirudinidae animal whitmania Whitmania pigra Whitman, leech Hirudo nipponica The hirudo leech of Whitman or willow leaf leech Whit-mania acranulata Whitman.It is salty, bitter, it puts down.With blood-breaking, by The effect of stasis of blood, promoting menstruation.For abdominal mass lump in the abdomen, blood stasis, injury from falling down.
Lotus nut：For the green radicle among the mature seed of nymphaeaceae plant lotus Nelumbo nucifera Gaertn. （Lotus nut）.Hardship is trembled with fear.Clearing away the heart fire and tranquillizing, restoring normal coordination between heart and kidney, unsmoothing the sperm and stopping bleeding.For the invasion of pericardium by heat, coma and delirium, breakdown of the normal physiological coordination between the heart and the kidney, insomnia something lost Essence, blood-head are spitted blood.
Radix Angelicae Sinensis：For umbelliferae angelica Angelica sinensis（Oliv.）The dry root of Diels.It is sweet, pungent, Temperature.Replenishing and activating blood, menstruction regulating and pain relieving relax bowel.For blood deficiency chlorosis, dizziness palpitaition, irregular menstruation, closed dysmenorrhea, cold of insufficiency type abdomen Bitterly, dry constipation of intestines, arthralgia pain due to rheumatism, injury from falling down, ulcer sores.Prepared RADIX ANGELICAE SINENSIS with yellow rice wine invigorate blood circulation.For closed dysmenorrhea, arthralgia pain due to rheumatism, Injury from falling down.
Matrimony vine：For the dry mature fruit of plant of Solanaceae lycium barbarum Lycium barbarum L..Sweet and neutral.Nourish liver Kidney, benefiting shrewd head.For consumption consumptive loss, soreness of waist and knee joint, dizziness and tinnitus, Heat Diabetes, blood deficiency chlorosis, blurred vision.
Akebi：For the woody stems of plants of Lardizabalaceae akebia trifoliata varaustralis or threeleaf akebia, akebi.Hardship, it is cool.Purging intense heat row water, tonneau blood Arteries and veins.Hot urination is controlled, stranguria with turbid discharge, oedema is irritable feverish sensation in chest, larynx numbness pharyngalgia, inflexible pain all over, women's Amenorrhea, alactation.
Chinese yam：For the dry rhizome of Dioscoreaceae plant Chinese yam Dioscorea opposita Thunb..Sweet and neutral.Tonifying spleen Nourishing the stomach, engender liquid and benefic lung, the puckery essence of kidney tonifying.For spleen eating less, endless diarrhea, the deficiency syndrome of the lung is breathed with cough, emission due to the kidney deficiency, under band, frequent micturition, and abnormal heat It quenches one's thirst.Rhizoma Dioscoreae (parched with bran) good efficacy to suffering from a deficiency of the kidney.For spleen eating less, diarrhea loose stool, leukorrhea.
Walnut kernel：For the dry mature seed of juglandaceae plant English walnut Juglans regia L..Sweet, warm.Kidney tonifying, temperature Lung, ease constipation.For soreness and weakness of waist and knees, impotence and seminal emission, cold of insufficiency type asthma is coughed, constipation.
Chrysophanol：Also known as chrysophanic acid.It is hexagon or the crystallization of monocline shape.It, can be strong with obvious antitussive action Power dissolves urate crystal.
Biological calcium carbonate：, crushing cleaned by the biological raw material without sintering such as eggshell, coral, shell, nacre, mistake It sieves.Calcium content is high, and calcium content is 3 times of calcium lactate, 4 times of calcium gluconate；Nutrition is good, absorptivity, utilization rate and Animal three indexs of weightening are superior to the calcium in milk, and cheap, free from extraneous odour, Small side effects.
Egg-shell meal：It is a kind of natural calcium source, and contains a certain amount of protein, the calcareous hard shell part of organized enzyme It is mainly made of calcium carbonate, followed by magnesium carbonate and calcium phosphate, calcium, phosphorus content account for eggshell in 34.9% and of substance respectively 0.2%, easily digested and assimilated by humans and animals.Egg-shell meal has stronger conservation rate to calcium, is absorbed after eating, digestibility height.
Honeysuckle：For caprifoliaceae plant honeysuckle Lonicera japonica Thunb., lonicera hypoglauca miq Lonicera Hypoglauca Miq., Honeysuckle flower（Hair calyx honeysuckle）Lonicera confusa DC. or hair style honeysuckle Lonicera The dry flower of dasystyla Rehd. or with the flower just opened.It is sweet, it trembles with fear.It is clearing heat and detoxicating, wind-heat dissipating.For carbuncle swells furunculosis, larynx Numbness, erysipelas, toxic-heat and blood stasis, anemopyretic cold, warm disease heating.
The root of straight ladybell：For four leaf the root of straight ladybell Adenophora tetraphylla of Campanulaceae the root of straight ladybell platymiscium（Thunb.） Fisch. [A. berticillata （Pall.）Fisch.], apricot leaf the root of straight ladybell A. axilliflora Borb [A. stricta Miq.] or its congener, it is used as medicine with root.It is sweet, it is cool.Clearing heat and nourishing yin moistens the lung and relieve the cough.Cure mainly tracheitis, pertussis, lung heat cough It coughs, cough up phlegm yellow thick.
Ramulus mori：For the dry twig of moraceae plants mulberry Morus alba L..Slight bitter is put down.Wind-damp dispelling, sharp joint.For shoulder Arm, joint pain are numb.
Monkshood：For the processed goods of the sub- root of ranunculaceae plant rhizome of Chinese monkshood Aconitum carmichaeli Debx..It is pungent, sweet, Big heat.Recuperating depleted yang, mends fire supporing yang, by wind-cold damp pathogen.It collapses for yang depletion, cold weak pulse of limb, impotence, Gong Leng, trusted subordinate's crymodynia, void It is cold to vomit and diarrhoea, cold sensation of the genitalia oedema, deficiency of yang diseases caused by external factors, numbness and ache of cold dampness.
Radix Glycyrrhizae：For glycyrrhizic legume Glycyrrhiza uralensis Fisch., swollen fruit Radix Glycyrrhiza The dry root of inflata Bat. or glycyrrhiza glabra Glycyrrhiza glabra L..Sweet and neutral.It invigorates the spleen and benefits qi, heat-clearing solution Poison, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.For weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity abdomen, four Limb contraction urgency pain, carbuncle sore tumefacting virus alleviate drug toxicity, strong.
First milk basic protein：Extract from colostrum 4/10000ths small molecule active albumen KD；Osteoblast is promoted to increase Grow, greatly enhance it is calcareous be absorbed and utilized, keep bone density；The Bones and joints nutrient of new generation to receive much attention.
Cordyceps sinensis：For section ergot fungus cordyceps sinensis bacterium Cordyceps sinensis（Berk.）Sacc. bat is colonized in The complex of stroma and larva corpse on hepialidae insect larvae.Sweet and neutral.Invigorating the lung and the kidney, hemostasis and phlegm.For chronic cough void Asthma, overstrain cough spitting of blood, impotence and seminal emission, soreness of waist and knee joint.
Lopseed：For Euphorbiaceae Speranskia plant speranskia tuberculata Speranskia tuberculata（Bunge） Baill., Balsaminaceae herbaceous plant balsamine Impatiens balsamina L., Bignoniaceae Chinese Incarvilla Herb platymiscium Chinese Incarvilla Herb Incarvillea sinensis Lam., pulse family Vetch plant vicia amoena Vicia amoena Fisch. herb and Ericaceae Gaultheria plant Caulis et folium gaultheriae yunnanensis Gaultheria yunnanensis（Franch.）Rehd. complete stool.Acrid flavour, property Temperature has promoting blood circulation：Evacuate pathogenic wind wins wet effect, with honeysuckle compatibility：Promoting blood circulation and stopping pain, the elimination stasis of blood are swollen, with ramulus mori compatibility：Dispelling wind and eliminating dampness is logical Up to four limbs yang-energy.
Semen momordicae：For cucurbitaceous plant Momordica cochinchiensis Momordica cochinchinensis（Lour.）Spreng. dry Dry mature seed.It is warm-natured, sweet in flavor, have：Detumescence, removing toxic substances, analgesic effect.
Dog bone glue：Warm-natured acrid flavour, have has anti-inflammatory analgetic effect, strengthening the muscles and bones effect to Bones and joints, can be used as adhesive Collectively as the external application of Chinese medicine paste of dissolving urate crystal.
Dissolved lithate becomes uric acid with blood is recycled into, and the uric acid in blood can in this way increased, and concentration increases Height still can deposit to form urate crystal with cycle in joint.So in blood, middle conjunction uric acid, and treatment gout The important link of disease.Uric acid is closed in blood must pay attention to two problems in the process：First, used middle mixture must be attached The demand of body transporting rule is closed, second is that safety and must be easy to absorb, and middle cooperation use can be given full play to.The present invention uses Biological food calcium carbonate calcium content：98% or more, pH value 8.5-9.5；The egg-shell meal of use contains various amino acid, calcium content 40% or more, pH value 10-11.Coordinate the uric acid closed in biological calcium carbonate in blood.It is applied with the lithate of neutralizing deposition, in blood In middle conjunction uric acid, to the urate crystal that reduces uric acid concentration gradually and deposited on joint.Urate crystal is dissolved Afterwards, with blood is recycled into, the uric acid concentration in blood can be made to increase, the PH in blood can be made to change（The PH of normal person Value is 7.35-7.45）, so that the pH value in blood is reduced, damaged to human body, form gout syndrome.
Heat toxin is one of cardinal symptom of gout, and clearing heat and detoxicating is the injury for inhibiting uric acid to human body.The present invention uses： Ramulus mori（It is mild-natured, bitter）Have：Heat-clearing, dredging collateral, reaches the effect of four limbs profit joint at wind-damp dispelling；Walnut kernel（It is warm-natured, sweet in flavor）Have： Moistening lung, nourishing liver, kidney, strong muscles and bones effect；Matrimony vine：（It is mild-natured, sweet in flavor）, there is protect liver, liver protection, improve immunocompetence effect； Chinese yam：Invigorating spleen and reinforcing stomach；Above all medicines protected during dissolving lithate and middle conjunction uric acid the vital organs of the human body and body tissue not by Injury.Cordyceps sinensis（It is mild-natured, sweet in flavor）Consolidate righting；Monkshood（Property heat, taste great Xin）Anti-inflammatory, analgesia；Recuperating depleted yang prevents uremic Occur and sudden lesion；Licorice（It is mild-natured, sweet in flavor）It invigorates the spleen and benefits qi, it is moistening lung, clearing heat and detoxicating, it is that blending is all with licorice emphasis Medicine, the poison for solving all medicines eliminate side effect.
When treating gout there is also a prodigious problem be exactly be dissolved after deposition lithate bone joint by The heavy corrosion of lithate is arrived, sclerotin receives destruction, must give and repair to impaired sclerotin while treating gout.This The sclerotin that invention is damaged using first milk basic protein reparation；First milk basic protein（CBP）It is that newest extraction is successfully answered in the world For the colostrum essence in health products；First milk basic protein is a kind of small molecular protein, thin with that can directly act on bone Born of the same parents promote bone metabolism, can coordinate the dynamic equilibrium of osteoblast and osteoclast, repair the effective work for being damaged sclerotin With.Absorptivity is high, and heat treatment and digestive ferment are not affected to its absorption.First milk basic protein is the best material for repairing sclerotin Material.
On the other hand, the preparation method of Chinese medicine preparation of the present invention is additionally provided comprising following steps：
The preparation of oral preparations：By leech, lotus nut, Radix Angelicae Sinensis, matrimony vine, akebi, Chinese yam, honeysuckle, the root of straight ladybell, ramulus mori, attached Then son, Radix Glycyrrhizae selected impurity elimination clean dust removal with water purification, drying is sieved, and is dried, is made under 45 ~ 50 DEG C of dustless air draft states Institute's water content<Stop dry cooling cause room temperature when 0.5%, is crushed to 300 ~ 400 mesh fine powders；Cordyceps sinensis, walnut kernel were crushed 400 mesh sieve；It is abundant that biological calcium carbonate, Chrysophanol, egg-shell meal, first milk basic protein is added after the above-mentioned raw material crushed is mixed Mixing, adds honey that ball is made；
The preparation of external application paste：It will be crushed after lopseed, semen momordicae impurity elimination, cross 60 mesh sieve, Chrysophanol and dog is added Gelatine fully stirs into dense paste, and external application paste is made according to conventional paste preparation process.
The positive effect of the present invention and advantage are：
, oral preparations and the two-way treatment gout of external application paste.It is integrally comprehensive using lytic agent, it is effective to dissolve The urate crystal being deposited on Bones and joints；Mixture in alkalinity is used simultaneously, having closed blood in thorough, effective neutralizes entrance Uric acid in blood makes blood restore normal pH value, eliminates the lesion of gout.
, oral preparations integrate the unified vital organs of the human body function that improved and improve metabolic capability, enhance oxidation resistance It prevents purine imbalance oxidation from generating uric acid, improves body immunity, the state of an illness is prevented to be mutated, be effectively guaranteed dissolving uric acid Salt crystallizes and the middle physiology transporting process for closing uric acid.
, using new material, effectively repaired after being corroded by urate crystal be damaged sclerotin, ensure that treatment pain The whole recovery effects of wind disease.
Specific implementation mode：
By following embodiment further illustrate description the present invention, do not limit the invention in any way, without departing substantially from Under the premise of technical solution of the invention, easy to implement any of those of ordinary skill in the art made for the present invention changes Dynamic or change is fallen within scope of the presently claimed invention.
Embodiment 1：
Oral preparations：Weigh 10 grams of leech, 15 grams of lotus nut, 14 grams of Radix Angelicae Sinensis, 15 grams of matrimony vine, 15 grams of akebi, 30 grams of Chinese yam, Impurity elimination is cleaned in 15 grams of 15 grams of honeysuckle, 15 grams of the root of straight ladybell, 15 grams of ramulus mori, 5 grams of monkshood, Radix Glycyrrhizae water purifications, is dried to water content at 50 DEG C < 0.5%, it is cooling to cause room temperature, it crushed 400 mesh sieve；10 grams of cordyceps sinensis, 30 grams of walnut kernel are crushed into 400 mesh；By above-mentioned material 10 grams of biological calcium carbonate, 5 grams of Chrysophanol, 5 grams of egg-shell meal, 10 grams of first milk basic protein is added to be sufficiently mixed uniformly, routinely Honeyed bolus, specification is made in honeyed bolus preparation process：50 milligrams every.
External application paste：It will be crushed after 15 grams of 15 grams of lopseed, semen momordicae impurity eliminations, cross 60 mesh sieve, 5 grams of Chrysophanol is added Dense paste is fully stirred into dog bone glue for 30 grams, and externally applied Chinese medicine paste is made according to conventional paste preparation process, is as applied with Paste.
Embodiment 2：
Oral preparations：Weigh 5 grams of leech, 10 grams of lotus nut, 10 grams of Radix Angelicae Sinensis, 10 grams of matrimony vine, 10 grams of akebi, 20 grams of Chinese yam, Impurity elimination is cleaned in 10 grams of 10 grams of honeysuckle, 10 grams of the root of straight ladybell, 10 grams of ramulus mori, 3 grams of monkshood, Radix Glycyrrhizae water purifications, is dried to water content at 45 DEG C < 0.5%, it is cooling to cause room temperature, it crushed 400 mesh sieve；10 grams of cordyceps sinensis, 20 grams of walnut kernel are crushed into 400 mesh；By above-mentioned material 5 grams of biological calcium carbonate, 3 grams of Chrysophanol, 3 grams of egg-shell meal, 5 grams of first milk basic protein is added to be sufficiently mixed uniformly, honey routinely Honeyed bolus, specification is made in ball preparation process：50 milligrams every.
External application paste：It will be crushed after 15 grams of 10 grams of lopseed, semen momordicae impurity eliminations, cross 60 mesh sieve, 5 grams of Chrysophanol is added Dense paste is fully stirred into dog bone glue for 20 grams, and externally applied Chinese medicine paste is made according to conventional paste preparation process, 20 grams of paste, As external application paste.
Embodiment 3：
Oral preparations：Weigh 8 grams of leech, 12 grams of lotus nut, 13 grams of Radix Angelicae Sinensis, 13 grams of matrimony vine, 13 grams of akebi, 25 grams of Chinese yam, Impurity elimination is cleaned in 13 grams of 13 grams of honeysuckle, 13 grams of the root of straight ladybell, 13 grams of ramulus mori, 4 grams of monkshood, Radix Glycyrrhizae water purifications, is dried to water content at 50 DEG C < 0.5%, it is cooling to cause room temperature, it crushed 400 mesh sieve；By 25 grams of 13 grams of cordyceps sinensis, walnut kernel 400 mesh of crushing；Above-mentioned material is added 8 grams of biological calcium carbonate, 4 grams of Chrysophanol, 4 grams of egg-shell meal, 8 grams of first milk basic protein are sufficiently mixed uniformly, honeyed bolus system routinely Honeyed bolus, specification is made in standby technique：50 milligrams every.
External application paste：It will be crushed after 15 grams of 15 grams of lopseed, semen momordicae impurity eliminations, cross 60 mesh sieve, 5 grams of Chrysophanol is added Dense paste is fully stirred into dog bone glue for 30 grams, and externally applied Chinese medicine paste is made according to conventional paste preparation process, is as applied with Paste.
Test example 1：Clinical effectiveness is studied
One, diagnostic criteria：
It is clinical criteria according to " modern Chinese medicine diagnostics " contained gout.
Gout is characterized as：Toes severe pain, redness, limitation of activity, it is immunocompromised, weak.
Urine examination：Uric acid concentration is exceeded；Inclusion criteria：
Two, instructions of taking and dose：
1, according to embodiments of the present invention 1 pill prepared is taken orally：30 points after meal, warm water clothes；
Just, early stage：
Twice a day, early, late each primary, each 500mg（Ten）
In：Later stage：
Three times a day, early, middle and late each primary, each 500mg（Ten）Or it follows the doctor's advice.
2, externally applied Chinese medicine paste：
The external application paste that according to embodiments of the present invention 1 prepares is spread on into affected part, changes within 3rd and applies once；
Three, effect criterion：
It is showed according to the commentary of diagnostic criteria：
It cures：The 2-3 course for the treatment of, symptom all disappear；
It is effective：Have after the 1-2 course for the treatment of obviously, alleviates or eliminate 70% or more symptom, can take care of oneself；
Effectively：There is alleviation after the 1-3 course for the treatment of or eliminates 50% or more symptom；
It is invalid：Without alleviation, no elimination performance after the 1-3 course for the treatment of；
1 each phase patient curative effect of table compares
Group Number of cases It cures It is effective Effectively In vain Cure rate
Just, early stage 19 16 2 1 0 84.21%
Middle and advanced stage 28 22 4 2 0 78.57%
It is carried altogether through clinical statistics and receives 47 people of gout patient；Wherein just, early stage：19 people；Middle and advanced stage：28 people.As a result table Bright, for first, early stage patient with gout, after treating the 1-3 course for the treatment of, cure rate has reached 84.21%, even with middle and advanced stage Patient with gout, after treating the 1-3 course for the treatment of, cure rate has also reached 78.57%, shows the Chinese medicine preparation of the present invention for gout There is preferable therapeutic effect.In addition, over the course for the treatment of, not finding any adverse reaction case.
Test example 2：Model case
Case 1：Gout medical record：Zeng, man, 45 years old.First visit on July 14 in 2012：Patient fed seafood, serious before 3 years Occur right vola pedis toe joint swelling heat pain after soup, touches a tender spot apparent, it is different in the medical uric acid 634umol/L blood fat of having a blood test of local hospital Often, urine is without exception." colchicin, Allopurinol " oral medication is given, the low fast diet of low fat is advised, does not continue to take medicine after remission Treatment, hereafter symptom repeatedly, slightly diet accidentally, the aggravations such as drink.It is existing symptoms include：The few China of sallow complexion, bitter taste stick greasy receive Slow-witted, distention and fullness in the abdomen, constipation is difficult to walk, scanty drak urine, and dizzy weak, tongue nature is light dim, yellow and greasy fur, veins string.Hospital assay result is shown： Hemoglobin 103g/L;Erythrocyte sedimentation rate 46mm/H；Urea nitrogen 53mmol/L;Creatinine 102umol/L;Urine proteins（+）, leucocyte 0-2/ HP.Comprehensive patient's illness, sign consider damp and hot turbid pathogenic factor retardance, the pharmaceutical preparation prepared using the embodiment of the present invention 1, disease after 3 days Shape is relieved, arthroncus, and pain is jumped in no fever, advise after take traditional Chinese medicine, externally applied drug tincture, after 1 week further consultation joint without red and swollen heat pain, Two is just normal, food intake can, pale tongue with thin fur is white, deficiency of QI with disinclination to talk.Consider that patient's prolonged illness is weak, gives the turbid Chinese medicine of invigorating spleen to remove dampnessization and be conducive to heresy Poison excretion, kidney-nourishing and essence-enriching herb are pacified the not ground by heresy, above-mentioned symptom and are obviously improved, and diet increases, and complexion is gradually moistened, and two just adjust, The thin white and moist pool of pink tongue tongue advises following the service to add medicine to March, and the state of an illness is without repeatedly within hereafter 1 year.
Case 2：Zhao, man, 51 years old.First visit on the 20th in 2 months in 2013：Patient went out biped plantar toe without apparent inducement before 7 years and closes Red and swollen heat pain is saved, is touched a tender spot apparent, in the medical uric acid 906umol/L that has a blood test of local hospital, dyslipidemia, urine is without exception.Give " the autumn Tazettine, Allopurinol " oral medication, advises low fat low purine diet, and hereafter symptom is repeatedly.In the recent period because of the greasy high protein of diet of celebrating the New Year or the Spring Festival Occur that biped articulationes metatarsophalangeae is unrestrained swollen, jumps pain with tubercle, it is existing symptoms include：Pale complexion is simple and unadorned cold, and the thin god of row is tired, pale tongue with thin fur, arteries and veins It counts accurately, physical examination temperature 37.6, erythrocyte sedimentation rate, 34 mm/H；721 umol/L of uric acid；Urine proteins（+）；Pathological biopsy is diagnosed as tophus. Comprehensive patient's illness, sign consideration deficiency-weakness of spleen-QI, wet turbid retention channels and collaterals, the pharmaceutical preparation prepared using the embodiment of the present invention 2,3 Symptom is relieved after it, arthroncus, and pain is jumped in no fever, advise after take traditional Chinese medicine, externally applied drug tincture, further consultation arthroncus is not after 1 week Aobvious, tubercle still exists, food intake can, pale tongue with thin fur is white, deficiency of QI with disinclination to talk.Consider that patient's prolonged illness is weak, gives the turbid Chinese medicine profit of invigorating spleen to remove dampnessization It is drained in cult poison, kidney-nourishing and essence-enriching herb is pacified the not ground by heresy, above-mentioned symptom and is obviously improved, and diet increases, and complexion is gradually moistened, and two just It adjusts, the thin white and moist pool of pink tongue tongue, advises following the service to add medicine to March, the state of an illness is without repeatedly within hereafter 2 years.
Case 3：Leaf, man, 58 years old.The first visit on the 14th of September in 2016：Patient happens suddenly right vola pedis toe joint swelling heat for 10 years Bitterly, it is diagnosed as gouty nephropathy in local hospital.Acute stage, gives " colchicin, Allopurinol " oral medication, advises low fat low Purine diet, hereafter Relapse rate breaking-out, voluntarily buying drug administrations, the state of an illness such as " gout spirits " improves unobvious, still instead repeatedly It is multiple.It is existing symptoms include：The soreness of waist is swollen, spiritlessness and weakness, and lower limb are slightly swollen, and food of receiving is fine, dry happiness drink, feverishness in palms and soles, and stool is adjusted, and urine is yellow, Pale tongue with indented margin, small and wiry pulse.Hospital assay result is shown：8.7 mmol/L of urea nitrogen；678 umol/L of uric acid；Urine proteins（++）, Occult blood（+++）.Comprehensive patient's illness, sign consider deficiency of both qi and yin, press from both sides wet folder and become silted up, the drug prepared using the embodiment of the present invention 3 Preparation, symptom is relieved after 1 week, no arthroncus, and pain is jumped in no fever, advises following the service Chinese medicine preparation, externally applied drug Chinese medicinal ointment, and 1 Without red and swollen heat pain, two is just normal in further consultation joint after week, food intake can, pale tongue with thin fur is white, light still to have the soreness of waist weak.Consider patient's prolonged illness Weakness is given the turbid Chinese medicine of invigorating spleen to remove dampnessization and is drained conducive to cult poison, and kidney-nourishing and essence-enriching herb is pacified the not ground by heresy, above-mentioned symptom and obviously changed Kind, diet increases, and complexion is gradually moistened, and two just adjust, the thin white and moist pool of pink tongue tongue, advises following the service to add medicine to half a year, the state of an illness is without anti-within hereafter 1 year It is multiple.

Claims (3)

1. a kind of Chinese medicine preparation of inside and outside two-way treatment gout, it is characterised in that it is made of oral preparations and externally applied formulation, In：
Oral preparations are made by ratio of weight and the number of copies of following raw material：
5 ~ 10 parts of leech, 10 ~ 15 parts of lotus nut, 10 ~ 15 parts of Radix Angelicae Sinensis, 10 ~ 15 parts of matrimony vine, 10 ~ 15 parts of akebi, 20 ~ 30 parts of Chinese yam, 20 ~ 30 parts of walnut kernel, 3 ~ 5 parts of Chrysophanol, 5 ~ 10 parts of biological calcium carbonate, 3 ~ 5 parts of egg-shell meal, 10 ~ 15 parts of honeysuckle, the root of straight ladybell 10 ~ 15 parts, 10 ~ 15 parts of ramulus mori, 3 ~ 5 parts of monkshood, 10 ~ 15 parts of Radix Glycyrrhizae, 5 ~ 10 parts of first milk basic protein, 5 ~ 10 parts of cordyceps sinensis；
External application paste is made by ratio of weight and the number of copies of following raw material：
10 ~ 15 parts of lopseed, 10 ~ 15 parts of semen momordicae, 3 ~ 5 parts of Chrysophanol, 20 ~ 30 parts of dog bone glue.
2. a kind of Chinese medicine preparation of inside and outside two-way treatment gout as described in claim 1, it is characterised in that：
Oral preparations are made by ratio of weight and the number of copies of following raw material：
10 parts of leech, 15 parts of lotus nut, 14 parts of Radix Angelicae Sinensis, 15 parts of matrimony vine, 15 parts of akebi, 30 parts of Chinese yam, 30 parts of walnut kernel, Chrysophanol 5 parts, 10 parts of biological calcium carbonate, 5 parts of egg-shell meal, 15 parts of honeysuckle, 15 parts of the root of straight ladybell, 15 parts of ramulus mori, 5 parts of monkshood, 15 parts of Radix Glycyrrhizae, just 10 parts of milk basic protein, 10 parts of cordyceps sinensis；
External application paste is made by ratio of weight and the number of copies of following raw material：
15 parts of lopseed, 15 parts of semen momordicae, 5 parts of Chrysophanol, 30 parts of dog bone glue.
3. a kind of preparation method of the Chinese medicine preparation of inside and outside two-way treatment gout as claimed in claim 1 or 2, feature exist In including the following steps：
The preparation of oral preparations：By leech, lotus nut, Radix Angelicae Sinensis, matrimony vine, akebi, Chinese yam, honeysuckle, the root of straight ladybell, ramulus mori, monkshood, sweet Then careless selected impurity elimination cleans dust removal with water purification, drying is sieved, and is dried under 45 ~ 50 DEG C of dustless air draft states, makes contained Moisture<Stop drying when 0.5% to be cooled to room temperature, is crushed to 300 ~ 400 mesh fine powders；Cordyceps sinensis, walnut kernel were crushed 400 mesh sieve；It is abundant that biological calcium carbonate, Chrysophanol, egg-shell meal, first milk basic protein is added after the above-mentioned raw material crushed is mixed Mixing, adds honey that ball is made；
The preparation of external application paste：It will be crushed after lopseed, semen momordicae impurity elimination, cross 60 mesh sieve, Chrysophanol and dog bone glue is added Dense paste is fully stirred into, external application paste is made according to conventional paste preparation process.
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