CN106924710A - A kind of Chinese medicine preparation of inside and outside two-way treatment gout and preparation method thereof - Google Patents

Abstract

The present invention relates to a kind of Chinese medicine preparation of inside and outside two-way treatment gout and preparation method thereof, it is made up of oral preparations and externally applied formulation, wherein oral preparations by 5 ~ 10 parts of leech, 10 ~ 15 parts of lotus nut, 10 ~ 15 parts of Radix Angelicae Sinensis, 10 ~ 15 parts of matrimony vine, etc. be made, external application paste is made up of 10 ~ 15 parts of lopseed, 10 ~ 15 parts of semen momordicae, 3 ~ 5 parts of Chrysophanol, 20 ~ 30 parts of dog bone glue.The present invention is coordinated dissolving for oral administration and is neutralized uric acid in blood using the lytic agent external application of dissolving lithate so that inside and outside two-way treatment gout, clinical effectiveness substantially, curative effect reliability.

Description

A kind of Chinese medicine preparation of inside and outside two-way treatment gout and preparation method thereof

Technical field：

The invention belongs to traditional Chinese medical science pharmaceutical technology field, and in particular to the Chinese medicine preparation and its system of a kind of inside and outside two-way treatment gout Preparation Method.

Background technology：

Gout is by monosodium urate salt（MSU）Deposition caused by crystal correlation arthropathy, with purine metabolic disturbance and（Or）Urine Hyperuricemia caused by acid excretion is reduced is directly related, refers in particular to acute characteristic arthritis and chronic gout stone disease, mainly Including acute attack arthritis, tophus formation, tophaceous chornic arthritis, urate nephropathy and uric acid urinary tract knot Stone, severe one may occur in which joint deformity and renal insufficiency.Gout due to the uric acid row for being included four height by people high, as difficulty With treatment, the different difficult illness of high recurrence rate, and due to there is presently no good, effective treatment method, the incidence of disease and newborn trouble Person is increasing year by year.At present, the crowd for suffering from gout, major part is between 40-50 Sui, the serious crisis body of people Health and have impact on operating efficiency.Gout has been aroused great concern, also into the different difficulty that medical matters circle are difficult to treat The problem that disease needs to capture into medical worker.

The hot rheumatism of gout traditional Chinese medical science appellation.So, motherland's medical science thinks in treatment method：" all sufferings sores all belong to the heart, all Wet turgor all belongs to spleen." so, use：Akebi（It is cold in nature sweet）Clearing away the heart-fire；Lotus nut（Bitter cold in nature）It is depressured the smooth rhythm of the heart, town It is quiet；Leech：（It is mild-natured, the salty hardship of taste）Purify the blood, dissipate the stasis of blood.Radix Angelicae Sinensis：（It is warm in nature, sweet）, promoting circulation of blood, blood-nourishing, enhancing blood circulation；Strengthen blood Liquid is circulated, and it is to treat the important measures of gout to improve metabolic capability.The taste of the above four has clearing away the heart-fire, purify the blood, promoting circulation of blood, blood-nourishing, Then stasis of blood effect, strengthens the metaboilic level of uric acid and purine.Using honeysuckle（Cold in nature, taste micro-sweet）With heat-clearing, detoxication. American Ginseng（It is micro- cool, sweet）With visible subsidy gas, heat-clearing, detoxication.

There is problems with treatment method at present：One is a lack of a kind of effective ways for dissolving urate crystal. Secondly being a lack of a kind of thoroughly middle method for closing uric acid continuous in blood.Thirdly being a lack of thoroughly repairing damaged joints sclerotin Effective material and method.Also, on the one hand want the function of the comprehensive adjustment body vital organs of the human body to put down during gout is treated Weighing apparatus, on the one hand will also improve the immunologic function of itself, and gout is treated under such medical principle can just obtain good effect Really.

Therefore, there is still a need for exploitation can effectively treat gout and toxic and side effect is small, be not easy the medicine of recurrence.

The content of the invention：

To solve technical barrier of the prior art, the invention provides the Chinese medicine preparation for the treatment of gout, its principle is to use The lytic agent external application of lithate is dissolved, coordinates the uric acid in dissolving for oral administration and neutralization blood, so that inside and outside two-way treatment is bitterly Wind, Chinese medicine preparation clinical effectiveness of the invention is obvious, curative effect reliability.

The present invention is that goal of the invention of the invention is realized by following technical scheme.

On the one hand, the invention provides a kind of Chinese medicine preparation of inside and outside two-way treatment gout, it is by oral preparations and outward Preparation composition is applied, wherein：

Oral preparations are made up of following raw materials by weight portion ratio：5 ~ 10 parts of leech, 10 ~ 15 parts of lotus nut, 10 ~ 15 parts of Radix Angelicae Sinensis, 10 ~ 15 parts of matrimony vine, 10 ~ 15 parts of akebi, 20 ~ 30 parts of Chinese yam, 20 ~ 30 parts of walnut kernel, 3 ~ 5 parts of Chrysophanol, biological calcium carbonate 5 ~ 10 Part, 3 ~ 5 parts of egg-shell meal, 10 ~ 15 parts of honeysuckle, 10 ~ 15 parts of the root of straight ladybell, 10 ~ 15 parts of ramulus mori, 3 ~ 5 parts of monkshood, 10 ~ 15 parts of Radix Glycyrrhizae, just 5 ~ 10 parts of milk basic protein, 5 ~ 10 parts of Chinese caterpillar fungus；

External application paste is made up of following raw materials by weight portion ratio：10 ~ 15 parts of lopseed, 10 ~ 15 parts of semen momordicae, Chrysophanol 3 ~ 5 Part, 20 ~ 30 parts of dog bone glue.

Preferably, oral preparations are made up of following raw materials by weight portion ratio：10 parts of leech, 15 parts of lotus nut, Radix Angelicae Sinensis 14 Part, 15 parts of matrimony vine, 15 parts of akebi, 30 parts of Chinese yam, 30 parts of walnut kernel, 5 parts of Chrysophanol, 10 parts of biological calcium carbonate, 5 parts of egg-shell meal, 15 parts of honeysuckle, 15 parts of the root of straight ladybell, 15 parts of ramulus mori, 5 parts of monkshood, 15 parts of Radix Glycyrrhizae, 10 parts of first milk basic protein, 10 parts of Chinese caterpillar fungus；External application Paste is made up of following raw materials by weight portion ratio：15 parts of lopseed, 15 parts of semen momordicae, 5 parts of Chrysophanol, 30 parts of dog bone glue.

Clinic confirms the key for treating gout is how to dissolve the urate crystal being deposited on joint.Due to gout Uric acid concentration in disease blood samples of patients is too high, can be deposited on Bones and joints when blood circulation is descending, particularly anklebone joint, deposition After become urate crystal, with blood circulation can thicken area increase, a part can be dissolved in treatment, have one on original surface Fixed alleviation, and uric acid crystal is not dissolved all actually, recurrent exerbation is understood after running into external cause, here it is gout is difficult With the place for curing, therefore, thoroughly dissolving urate crystal is the important prerequisite for curing gout.It is further characterized by：It is deposited on After lithate on joint is dissolved, blood circulation state is entered in the form of uric acid liquid, making the pH value of blood turns into acidity. The present invention is effectively middle in blood to close uric acid using mixture in alkalescence, and the uric acid concentration in blood is greatly lowered, and conforms to people The transporting rule of body acid-base balance, is that gout is positive, effective scientific method for treatment.Thought according to clinical observation repeatedly： At present, it is impossible to which the key for curing gout is can not thoroughly to dissolve and eliminate the urate crystal being deposited on Bones and joints, it is impossible to It is thoroughly middle in blood to close uric acid reduction uric acid concentration.

Also demonstrated in clinic：After lithate dissolves, into blood circulation process, because uric acid increases, the state of an illness can be produced Mutation, to prevent and suppressing sudden lesion, this invention takes clearing away the heart-fire, Pi benefit stomaches are good in sharp lung liver protection, and it is comprehensive that state's kidney supports kidney etc. Close conditioning, improve function effective measures and recuperating depleted yang, strengthen the body resistance to consolidate the constitution, it is anti-oxidant, improve and exempt from the auxiliary treatment of function Method, has effectively coordinated the treatment of gout, and benefit achieves remarkable result.In addition, being repaiied using a kind of strength of external invention The fine crisp new material of multiple bone-first milk basic protein, has played when gout is treated and has repaired by the destroyed of uric acid salt corrosion Osteocyte special role and remarkable result.

Gout is lacked of proper care by what purine metabolism, and superfluous purine is oxidized generation uric acid, and is deposited on blood circulation Bones and joints form urate crystal, go out to fold from membrana articulata under inducement effect, make periarticular red, swollen, urate crystal Locate Bones and joints pain unbearably.So, treatment gout key is to dissolve and eliminate the urate crystal on Bones and joints, eliminates morbidity disease Stove is the first step measure for treating gout mole.Chrysophanol is employed in innerwear Chinese medicine preparation of the present invention and is dissolved by blood circulation and urinated Hydrochlorate is crystallized, while also dissolving urate crystal, the source of used in the present invention raw material and effect using outer coating method It is as follows：

Leech：It is Hirudinidae animal whitmania Whitmania pigra Whitman, leech Hirudo nipponica Whitman Or the hirudo leech of willow leaf leech Whit-mania acranulata Whitman.Salty, hardship, puts down.With blood-breaking, by the stasis of blood, stimulate the menstrual flow Effect.For abdominal mass lump in the abdomen, blood stasis is through closing, injury from falling down.

Lotus nut：It is the green radicle in the middle of the mature seed of nymphaeaceae plant lotus Nelumbo nucifera Gaertn. （Lotus nut）.Hardship, trembles with fear.Clearing away the heart fire and tranquillizing, restoring normal coordination between heart and kidney, unsmoothing the sperm and stopping bleeding.For the invasion of pericardium by heat, coma and delirium, breakdown of the normal physiological coordination between the heart and the kidney, insomnia is lost Essence, blood-head is spitted blood.

Radix Angelicae Sinensis：It is umbelliferae angelica Angelica sinensis（Oliv.）The dry root of Diels.It is sweet, pungent, Temperature.Replenishing and activating blood, menstruction regulating and pain relieving relaxes bowel.For blood deficiency chlorosis, dizziness palpitaition, irregular menstruation, closed dysmenorrhea, cold of insufficiency type abdomen Bitterly, dry constipation of intestines, arthralgia pain due to rheumatism, injury from falling down, ulcer sores.Prepared RADIX ANGELICAE SINENSIS with yellow rice wine invigorate blood circulation.For closed dysmenorrhea, arthralgia pain due to rheumatism, Injury from falling down.

Matrimony vine：It is the dry mature fruit of plant of Solanaceae lycium barbarum Lycium barbarum L..It is sweet, put down.Nourishing liver Kidney, benefiting shrewd head.For consumption consumptive loss, soreness of waist and knee joint, dizziness and tinnitus, Heat Diabetes, blood deficiency chlorosis, blurred vision.

Akebi：It is plants of Lardizabalaceae akebia trifoliata varaustralis or threeleaf akebia, the woody stems of akebi.Hardship, it is cool.Purging intense heat water-filling, tonneau blood Arteries and veins.Hot urination is controlled, stranguria with turbid discharge, oedema is irritable feverish sensation in chest, larynx numbness pharyngalgia, inflexible pain all over, women's Amenorrhea, alactation.

Chinese yam：It is the dry rhizome of Dioscoreaceae plant Chinese yam Dioscorea opposita Thunb..It is sweet, put down.Tonifying spleen Nourishing the stomach, engender liquid and benefic lung, the puckery essence of kidney tonifying.For spleen eating less, endless diarrhea, the deficiency syndrome of the lung is breathed with cough, emission due to the kidney deficiency, under band, frequent micturition, abnormal heat Quench one's thirst.Rhizoma Dioscoreae (parched with bran) good efficacy to suffering from a deficiency of the kidney.For spleen eating less, diarrhea loose stool, leukorrhea.

Walnut kernel：It is the dry mature seed of juglandaceae plant English walnut Juglans regia L..It is sweet, temperature.Kidney tonifying, temperature Lung, ease constipation.For soreness and weakness of waist and knees, impotence and seminal emission, the cold of insufficiency type is breathed heavily and is coughed, constipation.

Chrysophanol：Also known as chrysophanic acid.It is hexagon or the crystallization of monocline shape.With obvious antitussive action, can be strong Power dissolves urate crystal.

Biological calcium carbonate：By the not sintered biological raw material such as eggshell, coral, shell, nacre it is cleaned, crush, mistake Sieve is formed.Calcium content is high, and its calcium content is 3 times of calcium lactate, 4 times of calcium gluconae；Nutrition is good, absorptivity, utilization rate and Animal three indexs of weightening are superior to the calcium in milk, and cheap, free from extraneous odour, Small side effects.

Egg-shell meal：It is a kind of natural calcium source, and containing a certain amount of protein, the calcareous duricrust part of organized enzyme Mainly it is made up of calcium carbonate, next to that magnesium carbonate and calcium phosphate, its calcium, phosphorus content account for eggshell in 34.9% and of material respectively 0.2%, easily digested and assimilated by humans and animals.Egg-shell meal has stronger conservation rate to calcium, and absorption, digestibility are high after eating.

Honeysuckle：It is caprifoliaceae plant honeysuckle Lonicera japonica Thunb., lonicera hypoglauca miq Lonicera Hypoglauca Miq., Honeysuckle flower（Hair calyx honeysuckle）Lonicera confusa DC. or hair style honeysuckle Lonicera The flower that the dry flower or band of dasystyla Rehd. are just opened.It is sweet, tremble with fear.It is clearing heat and detoxicating, wind-heat dissipating.For carbuncle swells furunculosis, larynx Numbness, erysipelas, toxic-heat and blood stasis, anemopyretic cold, warm disease heating.

The root of straight ladybell：It is the leaf the root of straight ladybell Adenophora tetraphylla of Campanulaceae the root of straight ladybell platymiscium four（Thunb.） Fisch. [A. berticillata （Pall.）Fisch.], apricot leaf the root of straight ladybell A. axilliflora Borb [A. stricta Miq.] or its congener, it is used as medicine with root.It is sweet, it is cool.Clearing heat and nourishing yin, moistens the lung and relieve the cough.Tracheitis is cured mainly, pertussis, lung heat is coughed Cough, cough up phlegm yellow thick.

Ramulus mori：It is the dry twig of moraceae plants mulberry Morus alba L..Slight bitter, puts down.Wind-damp dispelling, sharp joint.For shoulder Arm, joint pain are numb.

Monkshood：It is the processed goods of the sub- root of ranunculaceae plant rhizome of Chinese monkshood Aconitum carmichaeli Debx..It is pungent, sweet, Big heat.Recuperating depleted yang, mends fire supporing yang, by wind-cold damp pathogen.For yang depletion collapse, cold weak pulse of limb, impotence, Gong Leng, trusted subordinate's crymodynia is empty It is cold to vomit and diarrhoea, cold sensation of the genitalia oedema, deficiency of yang diseases caused by external factors, numbness and ache of cold dampness.

Radix Glycyrrhizae：It is glycyrrhizic legume Glycyrrhiza uralensis Fisch., swollen fruit Radix Glycyrrhiza The dry root of inflata Bat. or glycyrrhiza glabra Glycyrrhiza glabra L..It is sweet, put down.Invigorate the spleen and benefit qi, heat-clearing solution Poison, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.For weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity abdomen, four Limb contraction urgency pain, carbuncle sore tumefacting virus alleviate drug toxicity, strong.

First milk basic protein：Extract from colostrum 4/10000ths small molecule active albumen KD；Gegenbaur's cell is promoted to increase Grow, greatly strengthen it is calcareous absorb, keep bone density；The Bones and joints nutrient of new generation for receiving much attention.

Chinese caterpillar fungus：It is section ergot fungus cordyceps sinensis bacterium Cordyceps sinensis（Berk.）Sacc. bat is colonized in The complex of stroma and larva corpse on hepialidae insect larvae.It is sweet, put down.Invigorate the lung and the kidney, hemostasis and phlegm.It is empty for chronic cough Breathe heavily, labor is coughed spitting of blood, impotence and seminal emission, soreness of waist and knee joint.

Lopseed：It is Euphorbiaceae Speranskia plant speranskia tuberculata Speranskia tuberculata（Bunge） Baill., Balsaminaceae herbaceous plant balsamine Impatiens balsamina L., Bignoniaceae Chinese Incarvilla Herb platymiscium Chinese Incarvilla Herb Incarvillea sinensis Lam., the herb of pulse family Vetch plant vicia amoena Vicia amoena Fisch. and Ericaceae Gaultheria plant Caulis et folium gaultheriae yunnanensis Gaultheria yunnanensis（Franch.）Rehd. complete stool.Taste is pungent, property Temperature, with promoting blood circulation：Eradicates wind prevailing over dampness effects, with honeysuckle compatibility：Promoting blood circulation and stopping pain, the elimination stasis of blood swell, with ramulus mori compatibility：Dispelling wind and eliminating dampness is led to Up to four limbs yang-energy.

Semen momordicae：It is cucurbitaceous plant Momordica cochinchiensis Momordica cochinchinensis（Lour.）Spreng. dry Dry mature seed.It is warm in nature, sweet, have：Detumescence, removing toxic substances, analgesic effect.

Dog bone glue：Taste is pungent warm in nature, with thering is anti-inflammatory analgetic effect, strengthening the muscles and bones to act on to Bones and joints, can be used as adhesive Collectively as the external application of Chinese medicine paste of dissolving urate crystal.

Dissolved lithate turns into uric acid with blood is recycled into, and the uric acid in blood can so increased, and concentration increases Height, still can deposit to form urate crystal with circulation in joint.So, in blood, middle conjunction uric acid is also treatment gout The important step of disease.Two problems must be paid attention to during middle conjunction uric acid in blood：One is that the middle mixture for being used must be attached Close the demand of body transporting rule, two is safety and to be easy to absorb, it is possible to give full play to middle cooperation use.The present invention is used Biological food calcium carbonate calcium content：More than 98%, pH value 8.5-9.5；The egg-shell meal of use contains various amino acid, calcium content More than 40%, pH value 10-11.Coordinate the uric acid closed in blood in biological calcium carbonate.The lithate of external application neutralizing deposition, in blood In middle conjunction uric acid so that reduce gradually uric acid concentration and on joint deposit urate crystal.Urate crystal is dissolved Afterwards, with blood is recycled into, can increase the uric acid concentration in blood, the PH in blood can be made to change（The PH of normal person Value is 7.35-7.45）, the pH value in blood is reduced, damaged to human body, form gout syndrome.

Heat toxin is one of cardinal symptom of gout, and clearing heat and detoxicating is the injury for suppressing uric acid to human body.The present invention is used： Ramulus mori（It is mild-natured, bitter）Have：Heat-clearing, wind-damp dispelling, dredging collateral, up to four limbs profit joint effect；Walnut kernel（It is warm in nature, sweet）Have： Moistening lung, nourishing liver, kidney, strong muscles and bones effect；Matrimony vine：（It is mild-natured, sweet）, with protect liver, liver protection, improve immunocompetence effect； Chinese yam：Invigorating spleen and reinforcing stomach；More than all medicines protected during dissolving lithate and middle conjunction uric acid the vital organs of the human body and body tissue not by Injury.Chinese caterpillar fungus（It is mild-natured, sweet）Consolidate righting；Monkshood（Property heat, taste great Xin）Anti-inflammatory, analgesia；Recuperating depleted yang, prevents uremic Occur and sudden lesion；Licorice（It is mild-natured, sweet）Invigorate the spleen and benefit qi, it is moistening lung, clearing heat and detoxicating, with licorice it is important that blending is all Medicine, the poison for solving all medicines eliminates side effect.

Also there is a problem of when gout is treated one it is very big be exactly that the bone joint of deposition lithate after being dissolved is received The heavy corrosion of lithate is arrived, sclerotin receives destruction, impaired sclerotin must have been given while gout is treated and repaired.This The sclerotin that invention is damaged using first milk basic protein reparation；First milk basic protein（CBP）It is that newest extraction successfully should in the world For the colostrum elite in health products；First milk basic protein is a kind of small molecular protein, thin with that can directly act on bone Born of the same parents, promote bone metabolism, can coordinate the dynamic equilibrium of Gegenbaur's cell and osteoclast, repair effective work of impaired sclerotin With.Absorptivity is high, and heat treatment and digestive ferment are not affected to its absorption.First milk basic protein is the optimal material for repairing sclerotin Material.

On the other hand, the preparation method of Chinese medicine preparation of the present invention is additionally provided, it is comprised the following steps：

The preparation of oral preparations：By leech, lotus nut, Radix Angelicae Sinensis, matrimony vine, akebi, Chinese yam, honeysuckle, the root of straight ladybell, ramulus mori, monkshood, sweet Careless selected impurity elimination, then cleans dust removal with water purification, dries, sieves, and is dried under 45 ~ 50 DEG C of dustless air draft states, makes contained Moisture content<Stop drying cooling cause normal temperature when 0.5%, be crushed to 300 ~ 400 mesh fine powders；Chinese caterpillar fungus, walnut kernel are carried out crushing 400 Mesh sieve；Biological calcium carbonate, Chrysophanol, egg-shell meal, first milk basic protein is added fully to mix after the above-mentioned raw material for crushing is mixed Close, plus honey is made ball；

The preparation of external application paste：To be crushed after lopseed, semen momordicae impurity elimination, crossed 60 mesh sieves, added Chrysophanol and dog bone glue Dense pasty state is fully stirred into, external application paste is made according to conventional paste preparation technology.

The positive effect of the present invention and advantage are：

, oral preparations and the two-way treatment gout of external application paste.It is overall comprehensively using lytic agent, effectively dissolve heavy Urate crystal of the product on Bones and joints；Employ mixture in alkalescence simultaneously, thoroughly, it is effective in closed blood and neutralized and entered blood Uric acid in liquid, makes blood recover normal pH value, eliminates the focus of gout.

, comprehensively unified vital organs of the human body function of having nursed one's health improves metabolic capability to oral preparations, strengthens oxidation resistance Prevent purine from lacking of proper care and aoxidize generation uric acid, improve body immunity, prevent the state of an illness to be mutated, be effectively guaranteed dissolving uric acid Salt is crystallized and the middle physiology transporting process for closing uric acid.

, using new material, effectively repaired the sclerotin being damaged after being corroded by urate crystal, it is ensured that treatment pain The overall recovery effects of wind disease.

Specific embodiment：

Further illustrated the description present invention by following examples, the present invention is limited never in any form, without departing substantially from this hair On the premise of bright technical solution, those of ordinary skill in the art made for the present invention easily realize any change or Change is fallen within scope of the presently claimed invention.

Embodiment 1：

Oral preparations：Weigh 10 grams of leech, 15 grams of lotus nut, 14 grams of Radix Angelicae Sinensis, 15 grams of matrimony vine, 15 grams of akebi, 30 grams of Chinese yam, gold and silver Spend 15 grams, 15 grams of the root of straight ladybell, 15 grams of ramulus mori, 5 grams of monkshood, the cleaning impurity eliminations of 15 grams of water purification of Radix Glycyrrhizae, in 50 DEG C of dryings to water content ＜ 0.5%, cooling causes normal temperature, crushes 400 mesh sieves；10 grams of Chinese caterpillar fungus, 30 grams of walnut kernel are carried out to crush 400 mesh；By above-mentioned material plus Enter 10 grams of biological calcium carbonate, 5 grams of Chrysophanol, 5 grams of egg-shell meal, 10 grams of first milk basic protein to be sufficiently mixed uniformly, honey routinely Ball preparation technology is made honeyed bolus, specification：50 milligrams every.

External application paste：To be crushed after 15 grams of lopseed, 15 grams of impurity eliminations of semen momordicae, crossed 60 mesh sieves, added 5 grams of Chrysophanol 30 grams are fully stirred into dense pasty state with dog bone glue, and Externally applied Chinese medicine paste, as external application are made according to conventional paste preparation technology Paste.

Embodiment 2：

Oral preparations：Weigh 5 grams of leech, 10 grams of lotus nut, 10 grams of Radix Angelicae Sinensis, 10 grams of matrimony vine, 10 grams of akebi, 20 grams of Chinese yam, gold and silver Spend 10 grams, 10 grams of the root of straight ladybell, 10 grams of ramulus mori, 3 grams of monkshood, the cleaning impurity eliminations of 10 grams of water purification of Radix Glycyrrhizae, in 45 DEG C of dryings to water content ＜ 0.5%, cooling causes normal temperature, crushes 400 mesh sieves；10 grams of Chinese caterpillar fungus, 20 grams of walnut kernel are carried out to crush 400 mesh；By above-mentioned material plus Enter 5 grams of biological calcium carbonate, 3 grams of Chrysophanol, 3 grams of egg-shell meal, 5 grams of first milk basic protein to be sufficiently mixed uniformly, honeyed bolus routinely Preparation technology is made honeyed bolus, specification：50 milligrams every.

External application paste：To be crushed after 10 grams of lopseed, 15 grams of impurity eliminations of semen momordicae, crossed 60 mesh sieves, added 5 grams of Chrysophanol 20 grams are fully stirred into dense pasty state with dog bone glue, and Externally applied Chinese medicine paste is made according to conventional paste preparation technology, 20 grams of paste, As external application paste.

Embodiment 3：

Oral preparations：Weigh 8 grams of leech, 12 grams of lotus nut, 13 grams of Radix Angelicae Sinensis, 13 grams of matrimony vine, 13 grams of akebi, 25 grams of Chinese yam, gold and silver Spend 13 grams, 13 grams of the root of straight ladybell, 13 grams of ramulus mori, 4 grams of monkshood, the cleaning impurity eliminations of 13 grams of water purification of Radix Glycyrrhizae, in 50 DEG C of dryings to water content ＜ 0.5%, cooling causes normal temperature, crushes 400 mesh sieves；By 13 grams of Chinese caterpillar fungus, 25 grams of 400 mesh of crushing of walnut kernel；Above-mentioned material is added and is given birth to 8 grams of thing calcium carbonate, 4 grams of Chrysophanol, 4 grams of egg-shell meal, 8 grams of first milk basic protein are sufficiently mixed uniformly, prepared by honeyed bolus routinely Technique is made honeyed bolus, specification：50 milligrams every.

External application paste：To be crushed after 15 grams of lopseed, 15 grams of impurity eliminations of semen momordicae, crossed 60 mesh sieves, added 5 grams of Chrysophanol 30 grams are fully stirred into dense pasty state with dog bone glue, and Externally applied Chinese medicine paste, as external application are made according to conventional paste preparation technology Paste.

Test example 1：Clinical effectiveness is studied

First, diagnostic criteria：

It is clinical criteria according to " modern Chinese medicine diagnostics " contained gout.

Gout is characterized as：Toes severe pain, redness, limitation of activity, it is immunocompromised, weak.

Urine examination：Uric acid concentration is exceeded；Inclusive criteria：

2nd, instructions of taking and dose：

1st, oral according to embodiments of the present invention 1 pill for preparing：30 points after meal, warm water clothes；

Just, early stage：

Twice a day, early, evening is each once, each 500mg（Ten）

In：Later stage：

Three times a day, it is early, middle and late it is each once, each 500mg（Ten）Or follow the doctor's advice.

2nd, Externally applied Chinese medicine paste：

The external application paste that according to embodiments of the present invention 1 prepares is spread on into affected part, is changed within 3rd and is applied once；

3rd, effect criterion：

Commentary performance according to diagnostic criteria：

- cure：2-3 the course for the treatment of, symptom all disappear；

- effective：Have after the 1-2 course for the treatment of substantially, alleviate or eliminate symptom more than 70%, can take care of oneself；

- effectively：There is alleviation after the 1-3 course for the treatment of or eliminate symptom more than 50%；

- invalid：Without alleviation after the 1-3 course for the treatment of, showed without eliminating；

Each phase patient comparitive study of table 1

Group	Number of cases	Cure	It is effective	Effectively	It is invalid	Cure rate
							Just, early stage	19	16	2	1	0	84.21%
Middle and advanced stage	28	22	4	2	0	78.57%

Carried altogether through clinical statisticses and receive the people of gout patient 47；Wherein just, early stage：19 people；Middle and advanced stage：28 people.Result shows, right In first, early stage patient with gout, after the 1-3 course for the treatment of is treated, cure rate has reached 84.21%, even with middle and advanced stage gout Patient, treat the 1-3 course for the treatment of after, cure rate has also reached 78.57%, show Chinese medicine preparation of the invention for gout have compared with Good therapeutic effect.In addition, over the course for the treatment of, not finding any adverse reaction case.

Test example 2：Model case

Case 1：Gout medical record：Zeng, man, 45 years old.The first visit of July 14 in 2012：Patient took food after seafood, old fire-cooked soup before 3 years There is right vola pedis toe joint swelling heat pain, touch a tender spot obvious, it is small in the medical uric acid 634umol/L dyslipidemias of having a blood test of local hospital Just it is without exception." colchicin, Allopurinol " oral medication is given, the low fast diet of low fat is advised, medication treatment is not continued after remission, Hereafter symptom repeatedly, slightly diet accidentally, the aggravation such as drink.It is existing symptoms include：The few China of sallow complexion, bitter taste sticks greasy indigestion and loss of appetite, abdomen Turgor, constipation is difficult to walk, scanty drak urine, and dizzy weak, tongue nature is light dim, yellow and greasy fur, veins string.Hospital assay result is shown：It is blood red Protein 10 3g/L;Erythrocyte sedimentation rate 46mm/H；Urea nitrogen 53mmol/L;Creatinine 102umol/L;Urine proteins（+）, leucocyte 0-2/HP. Comprehensive patient's illness, sign consider that damp and hot turbid pathogenic factor blocks, the pharmaceutical preparation prepared using the embodiment of the present invention 1, and symptom is bright after 3 days Aobvious to alleviate, arthroncus without heating, jumps pain, advises following the service Chinese medicine, externally applied drug tincture, and without red and swollen heat pain, two just in further consultation joint after 1 week Normally, food intake can, pale tongue with thin fur is white, deficiency of QI with disinclination to talk.Consider that patient's prolonged illness is weak, give the turbid Chinese medicine of invigorating spleen to remove dampnessization to be arranged beneficial to evil poison Let out, kidney-nourishing and essence-enriching herb pacifies ground not by heresy, above-mentioned symptom is obviously improved, diet increases, complexion is gradually moistened, and two just adjust, tongue is weak The red thin white and moist pool of tongue, advises following the service to add medicine to March, and the state of an illness is without repeatedly within hereafter 1 year.

Case 2：Zhao, man, 51 years old.First visit on the 20th in 2 months in 2013：Patient went out biped plantar toe and closes before 7 years without obvious inducement Section red and swollen heat pain, touches a tender spot obvious, and in the medical uric acid 906umol/L that has a blood test of local hospital, dyslipidemia, urine is without exception.Give " the autumn Tazettine, Allopurinol " oral medication, advises low fat low purine diet, and hereafter symptom is repeatedly.In the recent period because of the New Year greasy high protein of diet Occur biped articulationes metatarsophalangeae it is unrestrained it is swollen, jump pain with tubercle, it is existing symptoms include：Pale complexion is simple and unadorned cold, and thin god is tired for row, pale tongue with thin fur, arteries and veins Count accurately, have a medical check-up temperature 37.6, erythrocyte sedimentation rate, 34 mm/H；The umol/L of uric acid 721；Urine proteins（+）；Pathological biopsy is diagnosed as tophus. Comprehensive patient's illness, sign consider deficiency-weakness of spleen-QI, wet turbid channels and collaterals of being detained, the pharmaceutical preparation prepared using the embodiment of the present invention 2,3 Symptom is relieved after it, arthroncus, without heating, jumps pain, advises following the service Chinese medicine, externally applied drug tincture, and further consultation arthroncus is not after 1 week Aobvious, tubercle still exists, food intake can, pale tongue with thin fur is white, deficiency of QI with disinclination to talk.Consider that patient's prolonged illness is weak, give the turbid Chinese medicine profit of invigorating spleen to remove dampnessization In evil poison excretion, kidney-nourishing and essence-enriching herb pacifies ground not by heresy, and above-mentioned symptom is obviously improved, and diet increases, and complexion is gradually moistened, and two just Adjust, the thin white and moist pool of pink tongue tongue, advise following the service to add medicine to March, the state of an illness is without repeatedly within hereafter 2 years.

Case 3：Leaf, man, 58 years old.The first visit on the 14th of September in 2016：Patient happens suddenly right vola pedis toe joint swelling heat for 10 years Bitterly, it is diagnosed as gouty nephropathy in local hospital.Acute stage, gives " colchicin, Allopurinol " oral medication, advises low fat low Purine diet, hereafter Relapse rate breaking-out, the voluntarily drug administration such as purchase " gout spirit ", the state of an illness improves not substantially, still it is anti-repeatedly It is multiple.It is existing symptoms include：The soreness of waist is swollen, spiritlessness and weakness, and lower limb slightly swell, and food of receiving is fine, and dry happiness drink, feverishness in palms and soles, stool is adjusted, and urine is yellow, Pale tongue with indented margin, small and wiry pulse.Hospital assay result is shown：The mmol/L of urea nitrogen 8.7；The umol/L of uric acid 678；Urine proteins（++）, Occult blood（+++）.Comprehensive patient's illness, sign consider deficiency of both qi and yin, press from both sides wet folder and become silted up, the medicine prepared using the embodiment of the present invention 3 Preparation, symptom is relieved after 1 week, without arthroncus, without heating, jumps pain, advises following the service Chinese medicine preparation, externally applied drug Chinese medicinal ointment, 1 Further consultation joint is without red and swollen heat pain after week, and two is just normal, food intake can, pale tongue with thin fur is white, light still to have the soreness of waist weak.Consider patient's prolonged illness Weakness, gives the turbid Chinese medicine of invigorating spleen to remove dampnessization to be drained beneficial to evil poison, and kidney-nourishing and essence-enriching herb pacifies ground not by heresy, and above-mentioned symptom substantially changes Kind, diet increases, and complexion is gradually moistened, and two just adjust, the thin white and moist pool of pink tongue tongue, advises following the service to add medicine to half a year, and the state of an illness is without anti-within hereafter 1 year It is multiple.

Claims (3)

1. a kind of Chinese medicine preparation of inside and outside two-way treatment gout, it is characterised in that be made up of oral preparations and externally applied formulation, its In：

Oral preparations are made up of following raw materials by weight portion ratio：5 ~ 10 parts of leech, 10 ~ 15 parts of lotus nut, 10 ~ 15 parts of Radix Angelicae Sinensis, 10 ~ 15 parts of matrimony vine, 10 ~ 15 parts of akebi, 20 ~ 30 parts of Chinese yam, 20 ~ 30 parts of walnut kernel, 3 ~ 5 parts of Chrysophanol, biological calcium carbonate 5 ~ 10 Part, 3 ~ 5 parts of egg-shell meal, 10 ~ 15 parts of honeysuckle, 10 ~ 15 parts of the root of straight ladybell, 10 ~ 15 parts of ramulus mori, 3 ~ 5 parts of monkshood, 10 ~ 15 parts of Radix Glycyrrhizae, just 5 ~ 10 parts of milk basic protein, 5 ~ 10 parts of Chinese caterpillar fungus；

External application paste is made up of following raw materials by weight portion ratio：10 ~ 15 parts of lopseed, 10 ~ 15 parts of semen momordicae, Chrysophanol 3 ~ 5 Part, 20 ~ 30 parts of dog bone glue.

2. Chinese medicine preparation as claimed in claim 1, it is characterised in that：

Oral preparations are made up of following raw materials by weight portion ratio：10 parts of leech, 15 parts of lotus nut, 14 parts of Radix Angelicae Sinensis, 15 parts of matrimony vine, 15 parts of akebi, 30 parts of Chinese yam, 30 parts of walnut kernel, 5 parts of Chrysophanol, 10 parts of biological calcium carbonate, 5 parts of egg-shell meal, 15 parts of honeysuckle, sand 15 parts of ginseng, 15 parts of ramulus mori, 5 parts of monkshood, 15 parts of Radix Glycyrrhizae, 10 parts of first milk basic protein, 10 parts of Chinese caterpillar fungus；

External application paste is made up of following raw materials by weight portion ratio：15 parts of lopseed, 15 parts of semen momordicae, 5 parts of Chrysophanol, dog bone glue 30 parts.

3. the preparation method of Chinese medicine preparation as claimed in claim 1 or 2, it is characterised in that comprise the following steps：

The preparation of oral preparations：By leech, lotus nut, Radix Angelicae Sinensis, matrimony vine, akebi, Chinese yam, honeysuckle, the root of straight ladybell, ramulus mori, monkshood, sweet Careless selected impurity elimination, then cleans dust removal with water purification, dries, sieves, and is dried under 45 ~ 50 DEG C of dustless air draft states, makes contained Moisture content<Stop drying cooling cause normal temperature when 0.5%, be crushed to 300 ~ 400 mesh fine powders；Chinese caterpillar fungus, walnut kernel are carried out crushing 400 Mesh sieve；Biological calcium carbonate, Chrysophanol, egg-shell meal, first milk basic protein is added fully to mix after the above-mentioned raw material for crushing is mixed Close, plus honey is made ball；

The preparation of external application paste：To be crushed after lopseed, semen momordicae impurity elimination, crossed 60 mesh sieves, added Chrysophanol and dog bone glue Dense pasty state is fully stirred into, external application paste is made according to conventional paste preparation technology.