CN112675282A - Composition for treating pneumonia, preparation method and particles prepared by composition - Google Patents
Composition for treating pneumonia, preparation method and particles prepared by composition Download PDFInfo
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Abstract
The invention provides a composition for treating pneumonia, a preparation method and granules prepared by the composition, and relates to the technical field of traditional Chinese medicines. The composition for treating pneumonia is prepared by reasonably matching ephedra herb, honey-fried licorice root, almond, cassia twig, rhizoma alismatis, grifola, bighead atractylodes rhizome, poria cocos, radix bupleuri, radix scutellariae, ginger, aster, winter flower, blackberry lily, gypsum, asarum, Chinese yam, immature bitter orange, dried orange peel and wrinkled gianthyssop herb. The invention also provides a preparation method of the composition and particles prepared from the composition. The invention has the advantages that the whole prescription can strengthen body resistance and eliminate pathogenic factors, sooth liver and reduce internal heat, and release lung and reduce phlegm, which is specifically shown in the following aspects: fever, spleen strengthening, dampness eliminating, yang warming, cough relieving, chest distress relieving, constipation relieving, diarrhea relieving, etc., and has wide application range, and can be taken by male, female, old and young. Meanwhile, the integral operation is simple and convenient, the popularization is convenient, and the preparation cost is low.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, and particularly relates to a composition for treating pneumonia, a preparation method and granules prepared by the composition.
Background
Pneumonia refers to inflammation of the terminal airways, alveoli and lung interstitium, and may be caused by disease microorganisms, physicochemical factors, immune injury, allergy and drugs. Bacterial pneumonia is the most common pneumonia and is also one of the most common infectious diseases. Pneumonia in daily life mainly refers to pneumonia caused by bacterial infection, and the pneumonia is also the most common pneumonia. Before the application of antibiotics, bacterial pneumonia threatens the health of children and old people greatly, the death rate of pneumonia is obviously reduced once by the appearance and development of the antibiotics, but in recent years, despite the application of powerful antibiotics and effective vaccines, the total death rate of pneumonia is not reduced or even increased. The common manifestations of pneumonia are fever, cough, expectoration, dyspnea and chest pain, and the symptoms gradually worsen with the course of disease and even endanger life.
Therefore, there is a need to develop a traditional Chinese medicine for effectively treating pneumonia.
Disclosure of Invention
The invention aims to provide a composition for treating pneumonia, which has the effects of tonifying spleen, clearing damp, warming yang, soothing liver, reducing internal heat, ventilating lung and resolving phlegm, can effectively treat the pneumonia and has low drug resistance.
The invention also aims to provide a preparation method of the composition for treating pneumonia, the preparation method obtains the composition for treating pneumonia by twice decoction, the whole operation is simple and convenient, the popularization is convenient, and the preparation cost is low.
Another object of the present invention is to provide granules prepared from the composition for treating pneumonia, wherein the granules are prepared by a specific concentration and drying process, can retain the active ingredients therein as much as possible, have a therapeutic effect equivalent to that of a water decoction, and are more convenient to use than the water decoction.
The technical problem to be solved by the invention is realized by adopting the following technical scheme.
On one hand, the embodiment of the application provides a composition for treating pneumonia, which comprises the following raw materials, by weight, 8-10 parts of ephedra, 5-7 parts of honey-fried licorice root, 5-7 parts of almond, 15-30 parts of gypsum, 8-10 parts of cassia twig, 8-10 parts of rhizoma alismatis, 8-10 parts of grifola, 8-10 parts of bighead atractylodes rhizome, 14-16 parts of poria cocos, 15-17 parts of radix bupleuri, 5-7 parts of radix scutellariae, 8-10 parts of ginger, 8-10 parts of aster, 8-10 parts of flos farae, 8-10 parts of blackberry lily, 5-7 parts of asarum, 11-13 parts of Chinese yam, 5-7 parts of immature bitter orange, 5-7 parts of dried orange peel and 8-10 parts of agastache rugosus.
In another aspect, the present application provides a preparation method of the aforementioned composition for treating pneumonia, including the following steps: soaking the raw materials, decocting for two times, filtering, and combining the filtrates to obtain the composition for treating pneumonia.
On the other hand, the embodiment of the application provides granules of the composition for treating pneumonia, which are mainly prepared by concentrating the composition for treating pneumonia to the relative density of 1.12-1.18, adding a filling agent and a lubricating agent, mixing, drying and granulating to obtain the granules.
In summary, compared with the prior art, the embodiments of the present invention have at least the following advantages or beneficial effects:
the invention provides a composition for treating pneumonia, which is prepared by reasonably matching ephedra herb, honey-fried licorice root, almond, cassia twig, rhizoma alismatis, polyporus, bighead atractylodes rhizome, poria cocos, radix bupleuri, radix scutellariae, ginger, aster, flos farfarae, blackberry lily, gypsum, asarum, Chinese yam, immature bitter orange, dried orange peel and wrinkled gianthyssop, and the whole formula can strengthen body resistance to eliminate pathogenic factors, sooth liver to remove internal heat, ventilate lung and reduce phlegm, and is specifically represented in the following steps: fever, spleen strengthening, dampness eliminating, yang warming, cough relieving, chest distress relieving, constipation relieving, diarrhea relieving, etc., and has wide application range, and can be taken by male, female, old and young.
In addition, according to the preparation method of the composition for treating pneumonia, provided by the invention, the composition for treating pneumonia is obtained by decocting twice, namely a decoction, beneficial ingredients in the decoction can be fully retained, the whole operation is simple and convenient, the popularization is convenient, and the preparation cost is low.
The invention also aims to provide granules prepared from the composition for treating pneumonia, wherein the granules are prepared by concentrating the composition for treating pneumonia to a relative density of 1.12-1.18, then adding a filler and a lubricant, drying and granulating, so that beneficial ingredients in the granules are conveniently stored, the granules are prevented from being decomposed and lost at high temperature, the finally formed granules have uniform particle size and are convenient to store, the treatment effect of the granules is equivalent to that of a decoction, and the granules are more convenient to use compared with the decoction.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
The embodiment of the application provides a composition for treating pneumonia, which comprises the following raw materials, by weight, 8-10 parts of ephedra, 5-7 parts of honey-fried licorice root, 5-7 parts of almond, 15-30 parts of gypsum, 8-10 parts of cassia twig, 8-10 parts of rhizoma alismatis, 8-10 parts of grifola, 8-10 parts of bighead atractylodes rhizome, 14-16 parts of poria cocos, 15-17 parts of radix bupleuri, 5-7 parts of radix scutellariae, 8-10 parts of ginger, 8-10 parts of aster, 8-10 parts of flos farae, 8-10 parts of blackberry lily, 5-7 parts of asarum, 11-13 parts of Chinese yam, 5-7 parts of immature bitter orange, 5-7 parts of dried orange peel and 8-10 parts of agastache rugosus.
Herba ephedrae: called Longsha, dog bone, inferior phase or inferior salt, is dry grass stem of Gnetum, Ephedra sinica Stapf or Ephedra equiseti Stapf. In autumn, green grass stems are harvested and dried in the sun. It has warm nature, pungent and slightly bitter taste, has effects of inducing sweat, dispelling cold, dispersing lung qi, relieving asthma, inducing diuresis, and relieving swelling, and can be used for treating wind-cold type common cold, chest distress, cough, and edema, and bronchial asthma.
Honey-fried licorice root: is prepared from radix Glycyrrhizae Preparata (baked with Mel) by decocting Mel in a pan to obtain Mel, adding radix Glycyrrhizae pieces with slow fire, parching, taking out of the pan for 3-5 min, oven drying at 60 deg.C in a baking room or oven, and cooling. Prepared licorice root, radix Glycyrrhizae Praeparata has the effects of regulating the stomach and strengthening the spleen, is commonly used for adjuvant treatment of symptoms such as physical fatigue, poor appetite, loose stool and the like caused by weakness of the spleen and the stomach, can eliminate phlegm, relieve cough and asthma, and can be used for treating symptoms such as cough, cold and the like; has antibacterial and antiviral effects, and can be used for treating gastric ulcer, skin pruritus, eczema, etc.; the composition contains licoflavone, and has antioxidant, toxic materials clearing away, antiinflammatory, and skin whitening effects.
Almond: is seed of Prunus Armeniaca L of Rosaceae. The apricot flesh contains various organic components, vitamins and inorganic salts necessary for human bodies, and the almond contains protein, fat, saccharides, various mineral substances such as calcium, phosphorus, iron, potassium and the like, and vitamins, so the apricot has more effects on the bodies: loosening bowel to relieve constipation: the apricot contains rich dietary fiber and water, on one hand, the dietary fiber can promote intestinal tract movement, and simultaneously can absorb water to swell so as to soften excrement, thereby achieving the effect of relaxing the bowels; delaying senility, maintaining beauty and keeping young: the apricot is rich in vitamin C and polyphenol substances, is a relatively strong antioxidant, has a certain antioxidation effect, can effectively remove redundant free radicals in the body, and avoids excessive oxidation of the free radicals, so that the effects of delaying senility and beautifying the face are achieved; improvement of cardiovascular symptoms: the apricot contains a large amount of flavonoids which have the function of regulating the activity of heart muscle and nerve, so that the eating of the apricot can help prevent the occurrence of cardiovascular system diseases to a certain extent.
Raw gypsum: i.e. natural dihydrate gypsum (CaSO)4·2H2O), according to the record of the ninth volume of the book of Ben Cao gang mu of Li Shi Zhen of Ming dynasty, "Sheng Shi is also called as fine marble and also called as" Hanshui Shi ", which is mainly used for treating wind-stroke, cold and heat, relieving muscles and sweating, removing dry mouth and tongue, headache and toothache, etc.
Cassia twig: is called as ramulus Cinnamomi, and is the dried twig of Cinnamomum cassia Presl of Lauraceae. Collected in spring and summer, has special fragrance, sweet and slightly pungent taste and thick skin taste. Pungent-warm property and warm-property, which tend to damage yin and blood, are contraindicated for exogenous febrile diseases, hyperactivity of fire due to yin deficiency, recklessly blood flow due to blood heat, etc.
Rhizoma alismatis: perennial aquatic or marsh herbs. Can be used for treating nephritis, edema, pyelonephritis, enteritis, diarrhea, dysuresia, etc.
And (3) polyporus umbellatus: a medicinal fungus belonging to family Polyporaceae, order Aphyllophorales, genus Dendropanaceae. The fruiting body is edible when young and tender, and has good taste. The underground sclerotium is black and various in shape, is a famous traditional Chinese medicine, and has the effects of promoting urination and treating edema.
White atractylodes rhizome: shezhiji, Yuzhu or Dongfu Baizhu, etc. Has effects of invigorating spleen, invigorating qi, eliminating dampness, promoting diuresis, arresting sweating, and preventing miscarriage, and can be used for treating spleen deficiency, anorexia, abdominal distention, diarrhea, phlegm and fluid retention, dizziness, edema, spontaneous perspiration, and threatened abortion.
Tuckahoe, poria cocos: also known as Yuling, Fu Ling, Wanling Gui or Fu Tu. Tranquilizing mind, removing toxic materials, and resisting cancer. Mild property and mild action, and induce diuresis without damaging healthy qi. Can be used for treating dysuria, edema, fullness, phlegm retention, cough, vomiting, diarrhea, spermatorrhea, stranguria with turbid urine, palpitation, and amnesia. The contained pachymic acid has effects of enhancing immunity, resisting tumor, tranquilizing mind, and lowering blood sugar. Can relax smooth muscle of digestive tract, inhibit gastric acid secretion, prevent hepatocyte necrosis, and resist bacteria.
Bupleurum root: it can be used for treating common cold, fever, malaria, stagnation of qi due to depression of the liver, distending pain of chest and hypochondrium, rectocele, metrorrhagia, and menoxenia.
Radix scutellariae: clearing heat and drying dampness, purging fire and removing toxicity, stopping bleeding, preventing miscarriage and reducing blood pressure. Can be used for treating chest distress, nausea, damp-heat, dysentery, jaundice, cough due to lung heat, hyperpyrexia, polydipsia, hematemesis, carbuncle, swelling, sore, and threatened abortion.
Ginger: pungent, mild and non-toxic. It is indicated for cough with mild heat in middle energizer, fullness and distention, cholera, abdominal pain, cold dysentery and blood block.
Aster root: can be used for treating cough, such as cough due to lung deficiency, consumptive lung disease, pulmonary abscess, cough with purulent blood, dysuresia, etc., and has effects of moistening lung, descending qi, eliminating phlegm, and relieving cough.
Winter flower: is a plant of the genus coltsfoot of the family Compositae. Contains protein and fat. Carbohydrates, multivitamins and multiminerals. The coltsfoot is pungent and warm in nature, and has the effects of moistening lung, descending qi, eliminating phlegm and relieving cough. It can be used for treating cough, asthma, and pharyngitis.
Shooting: is a perennial herb. The rhizome is medicinal, bitter in taste, cold in nature and slightly toxic. Has effects in clearing away heat and toxic materials, dispersing pathogen accumulation, relieving inflammation, swelling and pain, relieving cough, and eliminating phlegm, and can be used for treating tonsillitis and lumbago.
Asarum: is also called asarum sieboldii or asarum sieboldii. Has the effects of expelling wind, dispelling cold, promoting diuresis and inducing resuscitation. And has the functions of treating wind cold headache, nasosinusitis, toothache, phlegm and fluid retention cough, rheumatism, etc.
Chinese yam: is a dioscorea plant of Dioscoreaceae, and can be used for invigorating spleen and stomach deficiency, and treating qi deficiency, asthenia, dyspepsia, spermatorrhea, enuresis, and innominate toxic swelling.
Immature bitter orange: dried young fruit of Citrus aurantium L.of Rutaceae and cultivar or Citrus sinensis. Bitter, pungent and slightly sour, slightly warm. It enters spleen and stomach meridians. It can be used for treating stagnation, abdominal distention, pain, constipation, dysentery, abdominal distention, gastroptosis, uterine prolapse, and proctoptosis.
Dried orange peel: is mature pericarp of Rutaceae plant fructus Citri Tangerinae and its cultivar. For stomach qi failing to descend, nausea and vomiting, it is combined with Sheng Jiang if it is vomiting due to stomach cold; vomiting due to stomach heat.
Agastache rugosus: also named: hexiang, cang Ji or shan Feng Huo. Has the effects of eliminating turbid pathogen with aromatics, regulating the middle warmer, relieving vomit, relieving exterior syndrome and relieving summer-heat. Can be used for treating damp obstruction in middle warmer, abdominal distention, emesis, summer-heat dampness exterior syndrome, early stage of damp-warm syndrome, fever, listlessness, chest distress, cold-dampness, summer-heat, abdominal pain, emesis, diarrhea, nasosinusitis, and headache.
In some embodiments of the present invention, the composition for treating pneumonia comprises, by weight, 9 parts of ephedra, 6 parts of honey-fried licorice root, 6 parts of almond, 15 to 30 parts of gypsum, 9 parts of cassia twig, 9 parts of rhizoma alismatis, 9 parts of grifola, 9 parts of bighead atractylodes rhizome, 15 parts of poria cocos, 16 parts of radix bupleuri, 6 parts of radix scutellariae, 9 parts of ginger, 9 parts of aster, 9 parts of flos farfarae, 9 parts of blackberry lily, 6 parts of asarum, 12 parts of Chinese yam, 6 parts of immature bitter orange, 6 parts of dried orange peel and 9 parts of agastache rugosus.
In another aspect, the present application provides a method for preparing the composition for treating pneumonia, comprising the following steps: soaking the raw materials, decocting for two times, filtering, and combining the filtrates to obtain the composition for treating pneumonia.
In some embodiments of the present invention, the soaking time in the above preparation method is 20-40 min.
In some embodiments of the present invention, the decoction in the above preparation method includes the steps of adding water to submerge the raw materials, performing a first decoction, boiling for 2-3 min and then completing the decoction, performing solid-liquid separation to obtain a first liquid medicine and a first decoction dreg, adding water to the first decoction dreg and performing a second decoction, boiling for 2-3 min and then completing the decoction, performing solid-liquid separation to obtain a second liquid medicine, and combining the first liquid medicine and the second liquid medicine to obtain the composition for treating pneumonia.
In some embodiments of the present invention, the amount of water added in the second decoction is one-half of the amount of water added in the first decoction.
On the other hand, the embodiment of the application provides granules of a composition for treating pneumonia, which are mainly prepared by concentrating the composition for treating pneumonia to the relative density of 1.12-1.18, adding a filling agent and a lubricating agent, mixing, drying and granulating to obtain the granules.
In some embodiments of the present invention, the filler in the above granules is microcrystalline cellulose, and the amount of microcrystalline cellulose is 0.015%.
In some embodiments of the present invention, the lubricant in the above granules is magnesium stearate, and the amount of magnesium stearate is 0.01%.
In some embodiments of the present invention, the drying temperature in the above particles is 160 to 170 ℃.
The features and properties of the present invention are described in further detail below with reference to examples.
Example 1
The present embodiment aims to provide a composition for treating pneumonia, which is mainly prepared by the following steps:
1. cleaning herba Ephedrae, radix Glycyrrhizae Preparata, semen Armeniacae amarum, ramulus Cinnamomi, Alismatis rhizoma, Polyporus, Atractylodis rhizoma, Poria, bupleuri radix, Scutellariae radix, rhizoma Zingiberis recens, radix Asteris, flos Farfarae, rhizoma Belamcandae, herba asari, rhizoma Dioscoreae, fructus Aurantii Immaturus, pericarpium Citri Tangerinae and herba Agastaches respectively, removing impurities, and air drying in the ventilated place to obtain air-dried raw materials;
2. accurately weighing 8g of dried ephedra, 5g of honey-fried licorice root, 5g of almond, 8g of cassia twig, 8g of rhizoma alismatis, 8g of polyporus, 8g of bighead atractylodes rhizome, 14g of poria cocos, 15g of radix bupleuri, 5g of radix scutellariae, 8g of ginger, 8g of aster, 8g of flos farfarae, 8g of blackberry lily, 5g of asarum, 11g of Chinese yam, 5g of immature bitter orange, 5g of dried orange peel and 8g of wrinkled gianthyssop herb for later use;
3. adding the dried raw materials weighed in the step 2 into a pot, adding water for soaking for 20-40 min, so that the dried raw materials fully absorb water, beneficial components in the raw materials are conveniently released in the subsequent boiling process, the soaking time is preferably 30min, and after the soaking is finished, filtering and collecting the soaked raw materials;
4. adding 15g of gypsum into water, boiling with strong fire, adding the soaked medicinal materials, adding water into the soaked raw materials, decocting for the first time, boiling with strong fire for 2min, wherein the boiling time is not more than 3min, filtering, and separating to obtain a first liquid medicine and a first residue medicine;
5. adding half of water for the first decoction into the residue I, boiling with strong fire, boiling for 2min (no more than 3 min), filtering, and separating to obtain liquid II;
6. and combining the first liquid medicine and the second liquid medicine to obtain the composition for treating pneumonia.
Example 2
The present embodiment aims to provide a composition for treating pneumonia, which is mainly prepared by the following steps:
1. cleaning herba Ephedrae, radix Glycyrrhizae Preparata, semen Armeniacae amarum, ramulus Cinnamomi, Alismatis rhizoma, Polyporus, Atractylodis rhizoma, Poria, bupleuri radix, Scutellariae radix, rhizoma Zingiberis recens, radix Asteris, flos Farfarae, rhizoma Belamcandae, herba asari, rhizoma Dioscoreae, fructus Aurantii Immaturus, pericarpium Citri Tangerinae and herba Agastaches respectively, removing impurities, and air drying in the ventilated place to obtain air-dried raw materials;
2. accurately weighing 9g of dried ephedra, 6g of honey-fried licorice root, 6g of almond, 9g of cassia twig, 9g of rhizoma alismatis, 9g of polyporus, 9g of bighead atractylodes rhizome, 15g of poria cocos, 15g of radix bupleuri, 6g of radix scutellariae, 9g of ginger, 9g of aster, 9g of flos farfarae, 9g of blackberry lily, 6g of asarum, 12g of Chinese yam, 6g of immature bitter orange, 6g of dried orange peel and 9g of wrinkled gianthyssop herb for later use;
3. adding the dried raw materials weighed in the step 2 into a pot, adding water for soaking for 20-40 min, so that the dried raw materials fully absorb water, beneficial components in the raw materials are conveniently released in the subsequent boiling process, the soaking time is preferably 30min, and after the soaking is finished, filtering and collecting the soaked raw materials;
4. adding 23g of gypsum into water, boiling with strong fire, adding the soaked medicinal materials, adding water into the soaked raw materials, decocting for the first time, boiling with strong fire for 2min, wherein the boiling time is not more than 3min, filtering, and separating to obtain a first liquid medicine and a first residue medicine;
5. adding half of water for the first decoction into the residue I, boiling with strong fire, boiling for 2min (no more than 3 min), filtering, and separating to obtain liquid II;
6. and combining the first liquid medicine and the second liquid medicine to obtain the composition for treating pneumonia.
Example 3
The present embodiment aims to provide a composition for treating pneumonia, which is mainly prepared by the following steps:
1. cleaning herba Ephedrae, radix Glycyrrhizae Preparata, semen Armeniacae amarum, ramulus Cinnamomi, Alismatis rhizoma, Polyporus, Atractylodis rhizoma, Poria, bupleuri radix, Scutellariae radix, rhizoma Zingiberis recens, radix Asteris, flos Farfarae, rhizoma Belamcandae, herba asari, rhizoma Dioscoreae, fructus Aurantii Immaturus, pericarpium Citri Tangerinae and herba Agastaches respectively, removing impurities, and air drying in the ventilated place to obtain air-dried raw materials;
2. accurately weighing 10g of dried ephedra, 7g of honey-fried licorice root, 7g of almond, 10g of cassia twig, 10g of rhizoma alismatis, 10g of polyporus, 10g of bighead atractylodes rhizome, 16g of poria cocos, 17g of radix bupleuri, 7g of radix scutellariae, 10g of ginger, 10g of aster, 10g of flos farfarae, 10g of blackberry lily, 7g of asarum, 13g of Chinese yam, 7g of immature bitter orange, 7g of dried orange peel and 10g of wrinkled gianthyssop herb for later use;
3. adding the dried raw materials weighed in the step 2 into a pot, adding water for soaking for 20-40 min, so that the dried raw materials fully absorb water, beneficial components in the raw materials are conveniently released in the subsequent boiling process, the soaking time is preferably 30min, and after the soaking is finished, filtering and collecting the soaked raw materials;
4. adding 23g of gypsum into water, boiling with strong fire, adding the soaked medicinal materials, adding water into the soaked raw materials, decocting for the first time, boiling with strong fire for 2min, wherein the boiling time is not more than 3min, filtering, and separating to obtain a first liquid medicine and a first residue medicine;
5. adding half of water for the first decoction into the residue I, boiling with strong fire, boiling for 2min (no more than 3 min), filtering, and separating to obtain liquid II;
6. and combining the first liquid medicine and the second liquid medicine to obtain the composition for treating pneumonia.
Example 4
This example is intended to prepare the composition for treating pneumonia provided in example 1 into granules, and mainly includes the following steps:
1. carrying out low-temperature rotary evaporation on the composition for treating pneumonia, which is provided by the example 1, wherein the evaporation temperature is 40 ℃, and concentrating the composition to the relative density of 1.12-1.18 to obtain an intermediate product I;
2. adding the intermediate product I into a mixer, adding microcrystalline cellulose serving as a filler, and fully and uniformly mixing to obtain an intermediate product II, wherein the dosage of the microcrystalline cellulose in the intermediate product II is 0.015%;
3. adding magnesium stearate serving as a lubricant into the mixer, and fully mixing to obtain a third intermediate product, wherein the dosage of the magnesium stearate in the third intermediate product is 0.01%;
4. transferring the intermediate product III into a drying granulator, and drying and granulating at 160 ℃;
5. and (4) sieving the granules obtained in the step (4) until all granules are in a 60-80 mesh sieve, and filling to obtain the granules for treating pneumonia.
Example 5
This example is intended to prepare the composition for treating pneumonia provided in example 1 into granules, and mainly includes the following steps:
1. carrying out low-temperature rotary evaporation on the composition for treating pneumonia, which is provided by the example 1, wherein the evaporation temperature is 45 ℃, and concentrating the composition to the relative density of 1.12-1.18 to obtain an intermediate product I;
2. adding the intermediate product I into a mixer, adding microcrystalline cellulose serving as a filler, and fully and uniformly mixing to obtain an intermediate product II, wherein the dosage of the microcrystalline cellulose in the intermediate product II is 0.015%;
3. adding magnesium stearate serving as a lubricant into the mixer, and fully mixing to obtain a third intermediate product, wherein the dosage of the magnesium stearate in the third intermediate product is 0.01%;
4. transferring the intermediate product III into a drying granulator, and drying and granulating at 165 ℃;
5. and (4) sieving the granules obtained in the step (4) until all granules are in a 60-80 mesh sieve, and filling to obtain the granules for treating pneumonia.
Example 6
This example is intended to prepare the composition for treating pneumonia provided in example 1 into granules, and mainly includes the following steps:
1. carrying out low-temperature rotary evaporation on the composition for treating pneumonia, which is provided by the example 1, wherein the evaporation temperature is 50 ℃, and concentrating the composition to the relative density of 1.12-1.18 to obtain an intermediate product I;
2. adding the intermediate product I into a mixer, adding microcrystalline cellulose serving as a filler, and fully and uniformly mixing to obtain an intermediate product II, wherein the dosage of the microcrystalline cellulose in the intermediate product II is 0.015%;
3. adding magnesium stearate serving as a lubricant into the mixer, and fully mixing to obtain a third intermediate product, wherein the dosage of the magnesium stearate in the third intermediate product is 0.01%;
4. transferring the intermediate product III into a drying granulator, and drying and granulating at 170 ℃;
5. and (4) sieving the granules obtained in the step (4) until all granules are in a 60-80 mesh sieve, and filling to obtain the granules for treating pneumonia.
Examples of effects
The purpose of this effect example is to provide the therapeutic effects of the composition for treating pneumonia prepared in the foregoing examples and the particles further prepared therefrom.
The patients treated by the present method for years are counted by the inventor to obtain the following information
Table 1 therapeutic effect of the composition for treating pneumonia provided in example 2
| Type (B) | Total number of people | Show effect | Is effective | Invalidation | High efficiency |
| Fever with fever | 95 | 62 | 22 | 12 | 95％ |
| Pneumonia of lung | 61 | 37 | 11 | 13 | 90％ |
| Relieving cough | 186 | 128 | 50 | 8 | 99％ |
| Chest stuffiness | 52 | 32 | 10 | 10 | 91％ |
| Relaxing bowels | 110 | 69 | 23 | 18 | 93％ |
| Antidiarrheal | 145 | 94 | 33 | 18 | 95％ |
With the gradual acceleration of the pace of life of people, the water decoction cannot adapt to the fast-paced life of people more and more, so that the inventor further prepares the composition for treating pneumonia provided by the invention into particles, and makes statistics on the clinical information of the prepared particles to obtain the following treatment information:
table 2 therapeutic effect of the granules prepared in example 5
The water decoctions prepared in examples 1 and 3 were slightly inferior to those prepared in example 2 in practical use, but the effect was almost 90% or more. Therefore, in the further preparation of the granules, although the granules were prepared, the effect thereof was slightly inferior to that of the granules prepared in example 5, and the number of uses in the actual treatment was small, so that no statistics were made.
Therefore, the treatment effect of the granules is basically equivalent to that of a water decoction, and is better than that of the water decoction.
In conclusion, the composition for treating pneumonia provided by the invention is prepared by reasonably matching ephedra herb, honey-fried licorice root, almond, cassia twig, rhizoma alismatis, grifola, bighead atractylodes rhizome, poria cocos, radix bupleuri, radix scutellariae, ginger, aster, winter flower, blackberry lily, gypsum, asarum, Chinese yam, immature bitter orange, dried orange peel and wrinkled gianthyssop herb, ephedra herb, cassia twig, radix bupleuri, aster and Chinese yam are used as monarch drugs, so that the composition has the effects of inducing sweat, dispelling cold, ventilating lung, relieving asthma, tonifying spleen and benefiting lung; prepared licorice, rhizoma alismatis, scutellaria baicalensis, flos farfarae and immature bitter orange are taken as ministerial medicaments, lung moistening is performed, qi is sent, phlegm is reduced, cough is relieved, and stagnation is relieved; meanwhile, the almond, the grifola, the bighead atractylodes rhizome, the ginger processed pinellia tuber, the blackberry lily and the tangerine peel are used as adjuvant drugs, and the gypsum, the poria cocos, the ginger, the asarum and the agastache are used as conductant drugs, so that the curative effects of monarch and ministerial drugs are fully exerted, the whole prescription can be used for strengthening body resistance to eliminate pathogenic factors, soothing liver to reduce internal heat, ventilating lung to reduce phlegm, and the preparation can be used for effectively treating fever, strengthening spleen to eliminate dampness, warming yang, relieving cough, dispelling chest distress, relaxing bowels, relieving diarrhea and the like, is wide in application range.
In addition, according to the preparation method of the composition for treating pneumonia, the composition for treating pneumonia is obtained by decocting the raw materials for two times and boiling the decoction for a short time, namely the water decoction, so that the beneficial components in the composition are fully retained, the whole operation is simple and convenient, the popularization is convenient, and the preparation cost is low.
Another object of the present invention is to provide granules prepared from the composition for treating pneumonia, wherein the granules are prepared by concentrating the composition for treating pneumonia to a relative density of 1.12-1.18, adding a filler lubricant, a specific type of filler and lubricant, and specific amounts of filler and lubricant, which help to keep the granule shape stable, and protect the beneficial ingredients therein from the external conditions such as preparation process, etc., drying and granulating at a suitable temperature, so as to preserve the beneficial ingredients therein, prevent the beneficial ingredients from being decomposed and lost at a high temperature, and the finally formed granules have uniform particle size, so as to be convenient to preserve, have the same therapeutic effect as that of a decoction, and are more convenient to use than the decoction.
The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Claims (10)
1. The composition for treating pneumonia is characterized by comprising, by weight, 8-10 parts of ephedra, 5-7 parts of honey-fried licorice root, 5-7 parts of almond, 15-30 parts of gypsum, 8-10 parts of cassia twig, 8-10 parts of rhizoma alismatis, 8-10 parts of grifola, 8-10 parts of bighead atractylodes rhizome, 14-16 parts of poria cocos, 15-17 parts of radix bupleuri, 5-7 parts of radix scutellariae, 8-10 parts of ginger, 8-10 parts of aster, 8-10 parts of flos farae, 8-10 parts of blackberry lily, 5-7 parts of asarum, 11-13 parts of Chinese yam, 5-7 parts of immature bitter orange, 5-7 parts of dried orange peel and 8-10 parts of agastache rugosus.
2. The composition for treating pneumonia according to claim 1, which comprises the following raw materials, by weight, 9 parts of ephedra, 6 parts of honey-fried licorice root, 6 parts of almond, 15-30 parts of gypsum, 9 parts of cassia twig, 9 parts of rhizoma alismatis, 9 parts of grifola, 9 parts of bighead atractylodes rhizome, 15 parts of poria cocos, 16 parts of radix bupleuri, 6 parts of radix scutellariae, 9 parts of ginger, 9 parts of aster, 9 parts of flos farfarae, 9 parts of blackberry lily, 6 parts of asarum, 12 parts of Chinese yam, 6 parts of immature bitter orange, 6 parts of dried orange peel and 9 parts of agastache rugosus.
3. A method of preparing a composition for the treatment of pneumonia according to claim 1 or 2, comprising the steps of: soaking the raw materials, decocting for two times, filtering, and combining the filtrates to obtain the composition for treating pneumonia.
4. The preparation method according to claim 3, wherein the soaking time is 20-40 min.
5. The preparation method according to claim 3, wherein the decoction comprises the steps of adding water to submerge the raw materials, carrying out first decoction, boiling for 2-3 min, then completing the decoction, carrying out solid-liquid separation to obtain a first liquid medicine and a first decoction dregs, adding water to the first decoction dregs, carrying out second decoction, boiling for 2-3 min, then completing the decoction, carrying out solid-liquid separation to obtain a second liquid medicine, and combining the first liquid medicine and the second liquid medicine to obtain the composition for treating pneumonia.
6. The process according to claim 3, wherein the water added in the second decoction is half of the water added in the first decoction.
7. A granule of a composition for treating pneumonia, which is prepared mainly by concentrating the composition for treating pneumonia prepared by the preparation method of any one of claims 3 to 6 to a relative density of 1.12 to 1.18, adding a filler and a lubricant, mixing, drying and granulating to obtain the granule.
8. The granulate of claim 7, wherein the filler is microcrystalline cellulose, and wherein the microcrystalline cellulose is present in an amount of 0.015%.
9. The granulate of claim 7, wherein the lubricant is magnesium stearate, and wherein the magnesium stearate is present in an amount of 0.01%.
10. The granule according to claim 7, wherein the drying temperature is 160 to 170 ℃.
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Application publication date: 20210420 |