CN104435950A - Traditional Chinese medicinal styptic powder for treating upper gastrointestinal hemorrhage and preparation method thereof - Google Patents

Traditional Chinese medicinal styptic powder for treating upper gastrointestinal hemorrhage and preparation method thereof Download PDF

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CN104435950A
CN104435950A CN201410620719.5A CN201410620719A CN104435950A CN 104435950 A CN104435950 A CN 104435950A CN 201410620719 A CN201410620719 A CN 201410620719A CN 104435950 A CN104435950 A CN 104435950A
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parts
rhizoma
herba
styptic powder
powder
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赵霞
刘维宏
宋秀香
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708Rheum (rhubarb)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/618Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
    • AHUMAN NECESSITIES
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/26Aristolochiaceae (Birthwort family), e.g. heartleaf
    • A61K36/264Aristolochia (Dutchman's pipe)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/35Caprifoliaceae (Honeysuckle family)
    • A61K36/355Lonicera (honeysuckle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/66Papaveraceae (Poppy family), e.g. bloodroot
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/739Sanguisorba (burnet)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8967Lilium, e.g. tiger lily or Easter lily
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/898Orchidaceae (Orchid family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/899Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • AHUMAN NECESSITIES
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9062Alpinia, e.g. red ginger or galangal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/15Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

Abstract

The invention relates to a traditional Chinese medicinal formula, and particularly relates to traditional Chinese medicinal styptic powder for treating upper gastrointestinal hemorrhage and a preparation method thereof. The styptic powder is prepared from the following traditional Chinese medicinal raw materials in parts by weight: 15-20 parts of rhubarb, 15-20 parts of hericium erinaceus, 10-15 parts of capparis acutifolia, 9-15 parts of rhizoma corydalis, 9-15 parts of sanguisorba officinalis, 9-15 parts of pyrola, 9-15 parts of Chinese holly leaf, 6-12 parts of agrimonia pilosa ledeb, 6-12 parts of lily, 6-10 parts of honeysuckle, 6-8 parts of lalang grass rhizome, 5-9 parts of cuttlebone, 5-9 parts of dutchmanspipe vine, 3-9 parts of corydalis tuber, 3-9 parts of panax notoginseng, 3-6 parts of galangal, 3-6 parts of bletilla and 1-2 parts of narrow-leaved lindernia. The styptic powder has the advantages that the adopted traditional Chinese medicaments accord with the regulations of Pharmacopoeia of the People's Republic of China, so the styptic powder is safe, reliable, convenient to administrate, good in absorption effect, short in treatment course and quick in response, does not have any toxic or side effect, has high safety performance and is worthy of being widely popularized and applied on clinic.

Description

A kind of Chinese medicine styptic powder for the treatment of upper gastrointestinal hemorrhage disease and preparation method thereof
Technical field
The present invention relates to a kind of Chinese medicine formula, be specifically related to a kind of Chinese medicine styptic powder for the treatment of upper gastrointestinal hemorrhage disease and preparation method thereof.
Background technology
Upper gastrointestinal hemorrhage refers to the digestive tract of more than duodenum ligament, and what comprise caused by esophagus, Stomach duodenum or the pathological changes such as pancreas, gallbladder is hemorrhage.It is one of clinical common emergency case, and case fatality rate can reach more than 10%.
Basic treatment comprise lie up, fasting or liquid diet, intensive care, close observation etc.The treatment of protopathy also should be strengthened while stopping blooding, enriching blood.Clinical manifestation is based on hematemesis and melena.Patients with upper gastrointestinal hemorrhage all has melena, but not necessarily has hematemesis.Can occur after massive hemorrhage dizziness, dim eyesight, weak, be in a cold sweat, pale complexion, extreme cold of the limbs, the peripheral circulatory failure sign such as pulse quickening.The Therapeutic Principle of massive bleeding from upper digestive tract should take necessary emergency measures for hemorrhagic shock, and positive replenishment of blood content, stops blooding rapidly.Generally first adopt drug hemostasis, rear consideration operative treatment.
No matter adopt western medicine at present, but the action time of Western medicine is short more, advocates low dose of medication in the past, but upper gastrointestinal hemorrhage take hemostasis as top priority, be intravenous drip or oral drugs, and side effect is all very large, and haemostatic effect is not very desirable simultaneously.
Summary of the invention
According to above the deficiencies in the prior art, try hard to from the angle of health care, a kind of clearing away heat and cooling blood, invigorating the spleen and regulating the stomach are provided, the Chinese medicine styptic powder of the effect of the sharp intestinal that reduces phlegm and preparation method thereof.
A kind of Chinese medicine styptic powder for the treatment of upper gastrointestinal hemorrhage disease of the present invention, according to weight parts, prepared by following raw material of Chinese medicine: Radix Et Rhizoma Rhei 15-20 part, Hericium erinaceus (Bull. Ex Fr.) Pers. 15-20 part Herba Moslae Chinensis 10-15 part, Rhizoma Corydalis 9-15 part, Radix Sanguisorbae 9-15 part, Herba Pyrolae 9-15 part, Folium Ilicis Cornutae 9-15 part, Herba Agrimoniae 6-12 part, Bulbus Lilii 6-12 part, Flos Lonicerae 6-10 part, Rhizoma Imperatae 6-8 part, Endoconcha Sepiae 5-9 part, Herba Aristolochiae 5-9 part, Rhizoma Corydalis 3-9 part, Radix Notoginseng 3-9 part, Rhizoma Alpiniae Officinarum 3-6 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 3-6 part, Lindernia angustifolia (Benth.) Wettst. 1-2 part.
Treat a Chinese medicine styptic powder for upper gastrointestinal hemorrhage disease, according to weight parts, preferably formulated by following raw material of Chinese medicine: Radix Et Rhizoma Rhei 17 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 18 parts of Herba Moslae Chinensis 12 parts, Rhizoma Corydalis 11 parts, Radix Sanguisorbae 13 parts, Herba Pyrolae 12 parts, Folium Ilicis Cornutae 14 parts, Herba Agrimoniae 8 parts, Bulbus Lilii 8 parts, Flos Lonicerae 7 parts, Rhizoma Imperatae 7 parts, Endoconcha Sepiae 6 parts, Herba Aristolochiae 6 parts, Rhizoma Corydalis 7 parts, Radix Notoginseng 7 parts, Rhizoma Alpiniae Officinarum 5 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 4 parts, Lindernia angustifolia (Benth.) Wettst. 1 part.
Treat a preparation method for the Chinese medicine styptic powder of upper gastrointestinal hemorrhage disease, step is as follows:
(1) Herba Agrimoniae, Bulbus Lilii, Flos Lonicerae and Rhizoma Imperatae are cleaned, dry, put in pot, slow fire is fried, and frying to light brown is degree, and taking-up is ground into powder, crosses 120 order fine powders, for subsequent use;
(2) by Endoconcha Sepiae, Herba Aristolochiae, Rhizoma Corydalis, Radix Notoginseng and Rhizoma Alpiniae Officinarum parching to brown, after cooling completely, put into container, carry out pulverization process, grind into powder, cross 120 order fine powders, for subsequent use;
(3) Radix Et Rhizoma Rhei, Hericium erinaceus (Bull. Ex Fr.) Pers., Herba Moslae Chinensis, Rhizoma Corydalis, Radix Sanguisorbae, Herba Pyrolae, Folium Ilicis Cornutae, the Pseudobulbus Bletillae (Rhizoma Bletillae) and Lindernia angustifolia (Benth.) Wettst. are cleaned, chopping, put into container, immerse the alcohol solution dipping 3 ~ 4 hours of 80% of 4 times amount, heating extraction 1 hour, reclaim ethanol, by filter after filtrate collection, for subsequent use;
(4) by the filtrate obtained by above-mentioned steps and fine powder mixing, stir and make soft material, cross 20-25 mesh sieve and obtain granule styptic powder.
Described styptic powder is every part of 10-15g preferably, each 1 time of morning, noon and afternoon every day, warm water delivery service after meal.
Pharmacology analysis:
Radix Et Rhizoma Rhei: bitter in the mouth, cold in nature.Return spleen, stomach, large intestine, liver, pericardium channel.Function cures mainly: purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.For excess-heat constipation, stagnant stomachache, dysentery is not well, jaundice due to damp-heat, and heat in blood tells nosebleed, conjunctival congestion, pharyngeal swelling, abdominalgia with intestinal abscess, carbuncle furuncle, blood stasis amenorrhea, traumatic injury, external treatment burn due to hot liquid or fire; Upper gastrointestinal hemorrhage.Radix et Rhizoma Rhei (stir-fried with wine) is apt to clear part of the body cavity above the diaphragm housing the heart and lungs noxious heat in the blood system.For conjunctival congestion pharyngeal swelling, gingivitis.Radix Et Rhizoma Rhei rushes down exerts oneself to delay, eliminating fire and detoxication.For pathogenic fire,toxin and furuncles.Charred Radix Et Rhizoma Rhei cooling blood and removing stasis stops blooding.Stasis of blood hemorrhage is had for heat in blood.
Hericium erinaceus (Bull. Ex Fr.) Pers.: property is sweet; Taste is put down.Enter spleen, stomach warp.Strengthening the spleen and nourishing the stomach, calms the nerves, anticancer.Main body void is weak, dyspepsia, insomnia, gastroduodenal ulcer, chronic gastritis, digestive tract tumor.
Herba Moslae Chinensis: slightly warm in nature, acrid in the mouth.Drive away summer heat, invigorate blood circulation, regulate the flow of vital energy, removing dampness.Control Xia Yue flu, heatstroke vomiting and nausea, stomachache is had loose bowels, traumatic injury stasis of blood pain, eczema, furuncle and phyma.
Rhizoma Corydalis: warm in nature, acrid in the mouth is bitter, enters the heart, spleen, liver, lung, is the quality goods of blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, is especially world-famous for effect of pain relieving.Li Shizhen (1518-1593 A.D.) concludes Rhizoma Corydalis in Compendium of Material Medica " invigorate blood circulation, regulate the flow of vital energy, pain relieving, diuresis " four large effects, and praises highly Rhizoma Corydalis " can the stagnation of QI in promoting the circulation of blood, stasis in gas, therefore specially control upper and lower all pains all over the body ".
Radix Sanguisorbae: cold in nature, bitter in the mouth acid, nontoxic; Return liver, lung, kidney and large intestine channel.Cooling blood for hemostasis, removing toxic substances sore.For having blood in stool, hemorrhoidal bleeding, dysentery, metrorrhagia, burn due to hot liquid or fire, carbuncle sore tumefacting virus.
Herba Pyrolae: sweet in the mouth, hardship, temperature.Return liver, kidney channel.Wind-damp dispelling, bone and muscle strengthening, hemostasis.For rheumatic arthralgia, weakness of the waist and knees, menorrhagia, chronic cough due to asthenia of viscera.
Folium Ilicis Cornutae: bitter in the mouth, cool in nature.Return liver, kidney channel.Clearing away heat and nourishing YIN, suppressing the hyperactive liver, kidney tonifying.For pulmonary tuberculosis spitting of blood, osteopyrexia and fever, has a dizzy spell; Hypertension.
Herba Agrimoniae: bitter in the mouth, puckery, property is put down, GUIXIN, Liver Channel.Function cures mainly: astringing to arrest bleeding, preventing the attack (or recurrence) of malaria, dysentery relieving, removing toxic substances.For hemoptysis, spit blood, metrostaxis, malaria, dysentery, de-power impairment caused by overstrain, carbuncle sore tumefacting virus, pudendal pruritus leukorrhagia.
Bulbus Lilii: bitter in the mouth, cold nature.Enter the heart, lung meridian.Nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization.Nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization.For deficiency of YIN chronic cough, sputum mixed with blood, fidgets due to deficiency is palpitated with fear, insomnia and dreamful sleep, absentminded.There is nourishing YIN and moistening the lung cough-relieving effect, for the cough caused by dryness-heat of deficiency of lung-YIN.Control chronic cough of deficiency lung, chronic cough is spat blood.Have clearing away heart-fire for tranquillization effect, unclear for calentura waste heat, fidgets due to deficiency is palpitated with fear, insomnia and dreamful sleep etc.
Flos Lonicerae: cold in nature, sweet in the mouth, enters lung, the heart, stomach warp, has heat-clearing and toxic substances removing, antiinflammatory, tonify deficiency treat effect of wind, cures mainly disease under distension, epidemic febrile disease heating, the diseases such as pyretic toxicity carbuncle and ulcer and tumor.The diseases such as it is dizzy for giddy, xerostomia is done yearningly, hyperhidrosis is unhappy, enteritis, bacillary dysentery, measles, pneumonia, encephalitis b, epidemic encephalitis, acute mastitis, septicemia, appendicitis, skin infection, carbuncle furuncle, erysipelas, parotitis, suppurative tonsillitis all have certain curative effect.
Rhizoma Imperatae: sweet-bitter flavor, cold in nature, nontoxic.Function: removing heat from blood, hemostasis, heat clearing away, diuresis.Control calentura excessive thirst, spit blood, epistaxis, lung-heat dyspnea with rapid respiration, gastric heat hiccup, gonorrhea, dysuria, edema, jaundice.
Endoconcha Sepiae: salty in the mouth, puckery, slightly warm in nature.Return liver, kidney channel.Can astringing to arrest bleeding, relieving leukorrhea by astringents, antacid, sore.For acid regurgitation of having a stomachache, hematemesis and epistaxis, metrorrhagia is had blood in stool, emission and spermatorrhea, leucorrhea with red and white discharge; Peptic Ulcers.External treatment bleeding due to trauma, the many pus of skin ulcer.
Herba Aristolochiae: bitter in the mouth, warm in nature, return liver,spleen,kidney warp.Promoting flow of QI and blood, inducing diuresis to remove edema.For gastral cavity ventral spine pain, arthralgia, edema during pregnancy.
Rhizoma Corydalis: its tuber, containing the multiple alkaloid such as corydaline, protopine, through making powder or fluid-acet-extract etc., is invigorated blood circulation, promoting the circulation of QI, pain relieving.For the breast side of body, epigastric pain, amenorrhea dysmenorrhea, postpartum stagnation, tumbling and swelling.
Radix Notoginseng: hemostasis dissipating blood stasis, subduing swelling and relieving pain, has dissipating blood stasis hemostasis, effect of subduing swelling and relieving pain.Cure mainly spitting of blood, spit blood, epistaxis, has blood in stool, metrorrhagia, traumatic hemorrhage, and breast ventral spine pain, tumbling down swells and ache.
Rhizoma Alpiniae Officinarum: pungent, the large temperature of nature and flavor, nontoxic.Return spleen, stomach warp, function warming stomach for dispelling cold, help digestion pain relieving.For coldness and pain in the epigastrium, gastrofrigid vomiting, belch acid regurgitation.
The Pseudobulbus Bletillae (Rhizoma Bletillae): bitter in the mouth, sweet, puckery, cold nature.Return lung, liver, stomach warp.Cure mainly: astringing to arrest bleeding, detumescence and promoting granulation.Spit blood for hemoptysis, traumatic hemorrhage, sore swollen toxin, chapped skin; Pulmonary tuberculosis hemoptysis, ulcer haemorrhage.
Lindernia angustifolia (Benth.) Wettst.: property is put down, acrid in the mouth is bitter.The diarrhea of heat type that disappears wets, stomach function regulating, blood stasis removing.To harness the Yellow River subcutaneous ulcer, dysentery, acute gastroenteritis, acute laryngitis, tonsillitis, traumatic injury.
The invention has the advantages that used Chinese medicine meets Pharmacopoeia of People's Republic of China regulation, safety of medicine is reliable, taking convenience, good absorbing effect, and short treating period, instant effect, and without any side effects, security performance is high, is worth wide popularization and application clinically.
Collect 120 routine outpatient service upper gastrointestinal hemorrhage disease patients, man 60 example, female 60 example; Age 25-65 year, average 40 years old; Be divided into matched group (taking Cimitidine Tablets) and embodiment group at random, often organize 60 examples; Each group of patient age symptom is formed without significant difference; 3 times on the one, take medicine after meal at every turn, serve on 2 months.Statistics is as following table:
Number Cure Effective Effectively Invalid Effective percentage
Treatment group 60 53 5 1 1 98.3%
Matched group 60 5 6 10 39 35%
Efficacy evaluation:
Cure: spit blood in 1 week or melena stopping, continuous 3 days fecal occult blood testings (-), simultaneous phenomenon obviously improves;
Effective: to spit blood in 1 week or melena stopping, continuous 3 days fecal occult blood testings (+), simultaneous phenomenon makes moderate progress;
Effective: within 1 week, internal hemorrhage reduces, and fecal occult blood testing is transferred to (++) by strong positive, and simultaneous phenomenon slightly improves;
Invalid: through controlling 1 week haemophilia, severe bleeding even increases the weight of without taking a turn for the better after controlling 24h, and simultaneous phenomenon is also without improving or increasing the weight of.
Result: in treatment group, in 60 routine patients, effective and healing accounts for 58 examples, and cure rate accounts for 96.7%; In matched group, in 60 routine patients, effective and healing accounts for 11 examples, and cure rate accounts for 18.3%; To sum up, the cure rate for the treatment of group and effective percentage are apparently higher than matched group.
Below enumerate several model case:
Case 1:
Liu so-and-so, man, 40 years old, main suit's dull pain in the epigastrium, separate black defecate one day, had taste-blindness rate history in the past.When carrying out institute's inspection, pale complexion is simple and unadorned, the lips and tongue being pale, thready and weak pulse.Be diagnosed as massive bleeding from upper digestive tract.Take styptic powder of the present invention after 5 days, gastralgia slows, and enters diet less, and then continue to take 2 courses for the treatment of of this styptic powder, diet is normal gradually, and stool gradually turns yellow, then fully recovers after taking 3 courses for the treatment of, now recovers orthobiosis.
Case 2:
Grandson so-and-so, female, 55 years old, suffer from chronic gastritis 3 years, carry out hematemesis when institute goes to a doctor and occur having blood in stool, feces be obvious black, and spiritual poor, obnubilation, reacts slower.Through taking styptic powder of the present invention after 3 days, no longer hematemesis having blood in stool is eased, and feces recovers normal color.Various physical trait recovers normal, and the mental status is also fine.
Case 3:
Zhao so-and-so, man, 28 years old, have very large pressure at work, and be addicted to drink addicted to cigarette, before always by eating analgesic to palliate the agonizing sufferings, rear because of excessive consumption of alcohol cause gastrorrhagia come institute treatment, through taking styptic powder of the present invention after 2 days, no longer hematemesis, disappear completely through looking into gastrorrhagia symptom.Be discharged from hospitals upon recovery after the course for the treatment of.
Detailed description of the invention
Below in conjunction with embodiment, the present invention will be further described, but the present invention is not limited to specific embodiment.
Embodiment 1:
Treat a Chinese medicine styptic powder for upper gastrointestinal hemorrhage disease, according to weight parts, prepared by following raw material of Chinese medicine: Radix Et Rhizoma Rhei 15: part, Hericium erinaceus (Bull. Ex Fr.) Pers. 20 parts of Herba Moslae Chinensis 10 parts, Rhizoma Corydalis 15 parts, Radix Sanguisorbae 9 parts, Herba Pyrolae 15 parts, Folium Ilicis Cornutae 9 parts, Herba Agrimoniae 12 parts, Bulbus Lilii 6 parts, Flos Lonicerae 10 parts, Rhizoma Imperatae 6 parts, Endoconcha Sepiae 9 parts, Herba Aristolochiae 5 parts, Rhizoma Corydalis 9 parts, Radix Notoginseng 3 parts, Rhizoma Alpiniae Officinarum 6 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 3 parts, Lindernia angustifolia (Benth.) Wettst. 2 parts.
Embodiment 2:
Treat a Chinese medicine styptic powder for upper gastrointestinal hemorrhage disease, according to weight parts, prepared by following raw material of Chinese medicine: Radix Et Rhizoma Rhei 20 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 15 parts of Herba Moslae Chinensis 15 parts, Rhizoma Corydalis 9 parts, Radix Sanguisorbae 15 parts, Herba Pyrolae 9 parts, Folium Ilicis Cornutae 15 parts, Herba Agrimoniae 6 parts, Bulbus Lilii 12 parts, Flos Lonicerae 6 parts, Rhizoma Imperatae 8 parts, Endoconcha Sepiae 5 parts, Herba Aristolochiae 9 parts, Rhizoma Corydalis 3 parts, Radix Notoginseng 9 parts, Rhizoma Alpiniae Officinarum 3 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 6 parts, Lindernia angustifolia (Benth.) Wettst. 1 part.
Embodiment 3:
Treat a Chinese medicine styptic powder for upper gastrointestinal hemorrhage disease, according to weight parts, preferably formulated by following raw material of Chinese medicine: Radix Et Rhizoma Rhei 17 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 18 parts of Herba Moslae Chinensis 12 parts, Rhizoma Corydalis 11 parts, Radix Sanguisorbae 13 parts, Herba Pyrolae 12 parts, Folium Ilicis Cornutae 14 parts, Herba Agrimoniae 8 parts, Bulbus Lilii 8 parts, Flos Lonicerae 7 parts, Rhizoma Imperatae 7 parts, Endoconcha Sepiae 6 parts, Herba Aristolochiae 6 parts, Rhizoma Corydalis 7 parts, Radix Notoginseng 7 parts, Rhizoma Alpiniae Officinarum 5 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 4 parts, Lindernia angustifolia (Benth.) Wettst. 1 part.
Embodiment 4:
Treat a preparation method for the Chinese medicine styptic powder of upper gastrointestinal hemorrhage disease, step is as follows:
(1) Herba Agrimoniae in embodiment 1, Bulbus Lilii, Flos Lonicerae and Rhizoma Imperatae are cleaned, dry, put in pot, slow fire is fried, and frying to light brown is degree, and taking-up is ground into powder, crosses 120 order fine powders, for subsequent use;
(2) by Endoconcha Sepiae, Herba Aristolochiae, Rhizoma Corydalis, Radix Notoginseng and Rhizoma Alpiniae Officinarum parching to brown, after cooling completely, put into container, carry out pulverization process, grind into powder, cross 120 order fine powders, for subsequent use;
(3) Radix Et Rhizoma Rhei, Hericium erinaceus (Bull. Ex Fr.) Pers., Herba Moslae Chinensis, Rhizoma Corydalis, Radix Sanguisorbae, Herba Pyrolae, Folium Ilicis Cornutae, the Pseudobulbus Bletillae (Rhizoma Bletillae) and Lindernia angustifolia (Benth.) Wettst. are cleaned, chopping, puts into container, immerse the alcohol solution dipping 3 hours of 80% of 4 times amount, heating extraction 1 hour, reclaim ethanol, by filter after filtrate collection, for subsequent use;
(4) by the filtrate obtained by above-mentioned steps and fine powder mixing, stir and make soft material, cross 20 mesh sieves and obtain granule styptic powder.
Described styptic powder every part 10g, each 1 time of morning, noon and afternoon every day, warm water delivery service after meal.
Embodiment 5:
Treat a preparation method for the Chinese medicine styptic powder of upper gastrointestinal hemorrhage disease, step is as follows:
(1) Herba Agrimoniae in embodiment 2, Bulbus Lilii, Flos Lonicerae and Rhizoma Imperatae are cleaned, dry, put in pot, slow fire is fried, and frying to light brown is degree, and taking-up is ground into powder, crosses 120 order fine powders, for subsequent use;
(2) by Endoconcha Sepiae, Herba Aristolochiae, Rhizoma Corydalis, Radix Notoginseng and Rhizoma Alpiniae Officinarum parching to brown, after cooling completely, put into container, carry out pulverization process, grind into powder, cross 120 order fine powders, for subsequent use;
(3) Radix Et Rhizoma Rhei, Hericium erinaceus (Bull. Ex Fr.) Pers., Herba Moslae Chinensis, Rhizoma Corydalis, Radix Sanguisorbae, Herba Pyrolae, Folium Ilicis Cornutae, the Pseudobulbus Bletillae (Rhizoma Bletillae) and Lindernia angustifolia (Benth.) Wettst. are cleaned, chopping, puts into container, immerse the alcohol solution dipping 4 hours of 80% of 4 times amount, heating extraction 1 hour, reclaim ethanol, by filter after filtrate collection, for subsequent use;
(4) by the filtrate obtained by above-mentioned steps and fine powder mixing, stir and make soft material, cross 25 mesh sieves and obtain granule styptic powder.
Described styptic powder every part 15g, each 1 time of morning, noon and afternoon every day, warm water delivery service after meal.
Embodiment 6:
Treat a preparation method for the Chinese medicine styptic powder of upper gastrointestinal hemorrhage disease, step is as follows:
(1) Herba Agrimoniae in embodiment 3, Bulbus Lilii, Flos Lonicerae and Rhizoma Imperatae are cleaned, dry, put in pot, slow fire is fried, and frying to light brown is degree, and taking-up is ground into powder, crosses 120 order fine powders, for subsequent use;
(2) by Endoconcha Sepiae, Herba Aristolochiae, Rhizoma Corydalis, Radix Notoginseng and Rhizoma Alpiniae Officinarum parching to brown, after cooling completely, put into container, carry out pulverization process, grind into powder, cross 120 order fine powders, for subsequent use;
(3) Radix Et Rhizoma Rhei, Hericium erinaceus (Bull. Ex Fr.) Pers., Herba Moslae Chinensis, Rhizoma Corydalis, Radix Sanguisorbae, Herba Pyrolae, Folium Ilicis Cornutae, the Pseudobulbus Bletillae (Rhizoma Bletillae) and Lindernia angustifolia (Benth.) Wettst. are cleaned, chopping, put into container, immerse the alcohol solution dipping 3.5 hours of 80% of 4 times amount, heating extraction 1 hour, reclaim ethanol, by filter after filtrate collection, for subsequent use;
(4) by the filtrate obtained by above-mentioned steps and fine powder mixing, stir and make soft material, cross 20 mesh sieves and obtain granule styptic powder.
Described styptic powder is every part of 12g preferably, each 1 time of morning, noon and afternoon every day, warm water delivery service after meal.
Above the implementation that specific embodiments is described is intended to specific descriptions of the present invention, can not be interpreted as it is limitation of the present invention.Under the teachings of the present invention, can make various variant on the basis of the embodiment described in detail, these variants all should be included within design of the present invention those of ordinary skill in the art.The present invention's scope required for protection is only limited by described claims.

Claims (4)

1. treat the Chinese medicine styptic powder of upper gastrointestinal hemorrhage disease for one kind, it is characterized in that: according to weight parts, prepared by following raw material of Chinese medicine: Radix Et Rhizoma Rhei 15-20 part, Hericium erinaceus (Bull. Ex Fr.) Pers. 15-20 part Herba Moslae Chinensis 10-15 part, Rhizoma Corydalis 9-15 part, Radix Sanguisorbae 9-15 part, Herba Pyrolae 9-15 part, Folium Ilicis Cornutae 9-15 part, Herba Agrimoniae 6-12 part, Bulbus Lilii 6-12 part, Flos Lonicerae 6-10 part, Rhizoma Imperatae 6-8 part, Endoconcha Sepiae 5-9 part, Herba Aristolochiae 5-9 part, Rhizoma Corydalis 3-9 part, Radix Notoginseng 3-9 part, Rhizoma Alpiniae Officinarum 3-6 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 3-6 part, Lindernia angustifolia (Benth.) Wettst. 1-2 part.
2. a kind of Chinese medicine styptic powder for the treatment of upper gastrointestinal hemorrhage disease according to claim 1, is characterized in that: according to weight parts, formulated by following raw material of Chinese medicine: Radix Et Rhizoma Rhei 17 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 18 parts of Herba Moslae Chinensis 12 parts, Rhizoma Corydalis 11 parts, Radix Sanguisorbae 13 parts, Herba Pyrolae 12 parts, Folium Ilicis Cornutae 14 parts, Herba Agrimoniae 8 parts, Bulbus Lilii 8 parts, Flos Lonicerae 7 parts, Rhizoma Imperatae 7 parts, Endoconcha Sepiae 6 parts, Herba Aristolochiae 6 parts, Rhizoma Corydalis 7 parts, Radix Notoginseng 7 parts, Rhizoma Alpiniae Officinarum 5 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 4 parts, Lindernia angustifolia (Benth.) Wettst. 1 part.
3. a preparation method for the Chinese medicine styptic powder for the treatment of upper gastrointestinal hemorrhage disease according to claim 1, it is characterized in that, step is as follows:
(1) Herba Agrimoniae, Bulbus Lilii, Flos Lonicerae and Rhizoma Imperatae are cleaned, dry, put in pot, slow fire is fried, and frying to light brown is degree, and taking-up is ground into powder, crosses 120 order fine powders, for subsequent use;
(2) by Endoconcha Sepiae, Herba Aristolochiae, Rhizoma Corydalis, Radix Notoginseng and Rhizoma Alpiniae Officinarum parching to brown, after cooling completely, put into container, carry out pulverization process, grind into powder, cross 120 order fine powders, for subsequent use;
(3) Radix Et Rhizoma Rhei, Hericium erinaceus (Bull. Ex Fr.) Pers., Herba Moslae Chinensis, Rhizoma Corydalis, Radix Sanguisorbae, Herba Pyrolae, Folium Ilicis Cornutae, the Pseudobulbus Bletillae (Rhizoma Bletillae) and Lindernia angustifolia (Benth.) Wettst. are cleaned, chopping, put into container, immerse the alcohol solution dipping 3 ~ 4 hours of 80% of 4 times amount, heating extraction 1 hour, reclaim ethanol, by filter after filtrate collection, for subsequent use;
(4) by the filtrate obtained by above-mentioned steps and fine powder mixing, stir and make soft material, cross 20-25 mesh sieve and obtain granule styptic powder.
4. a kind of preparation method for the treatment of the Chinese medicine styptic powder of upper gastrointestinal hemorrhage disease according to claim 1, is characterized in that: described styptic powder every part 10-15g, each 1 time of morning, noon and afternoon every day, warm water delivery service after meal.
CN201410620719.5A 2014-11-06 2014-11-06 Traditional Chinese medicinal styptic powder for treating upper gastrointestinal hemorrhage and preparation method thereof Pending CN104435950A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106728981A (en) * 2015-11-19 2017-05-31 哈尔滨圣吉药业股份有限公司 A kind of common jujube root Zhixue soluble granules and preparation method thereof

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102688426A (en) * 2012-06-25 2012-09-26 许梅 Traditional Chinese medicine composition for treating acute upper gastrointestinal hemorrhage, as well as preparation method and application thereof
CN103845673A (en) * 2014-03-20 2014-06-11 张小丽 Medicine for treating upper gastrointestinal hemorrhage and preparation method thereof
CN104001131A (en) * 2014-05-26 2014-08-27 崔峰 Oral traditional Chinese medicine for preventing and treating stress ulcers

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102688426A (en) * 2012-06-25 2012-09-26 许梅 Traditional Chinese medicine composition for treating acute upper gastrointestinal hemorrhage, as well as preparation method and application thereof
CN103845673A (en) * 2014-03-20 2014-06-11 张小丽 Medicine for treating upper gastrointestinal hemorrhage and preparation method thereof
CN104001131A (en) * 2014-05-26 2014-08-27 崔峰 Oral traditional Chinese medicine for preventing and treating stress ulcers

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106728981A (en) * 2015-11-19 2017-05-31 哈尔滨圣吉药业股份有限公司 A kind of common jujube root Zhixue soluble granules and preparation method thereof

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Application publication date: 20150325