CN104258151A - Drug for treating nephropyelitis and preparation method thereof - Google Patents

Drug for treating nephropyelitis and preparation method thereof Download PDF

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CN104258151A
CN104258151A CN201410525744.5A CN201410525744A CN104258151A CN 104258151 A CN104258151 A CN 104258151A CN 201410525744 A CN201410525744 A CN 201410525744A CN 104258151 A CN104258151 A CN 104258151A
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herba
folium
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张禾云
岳素敏
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Abstract

The invention discloses a drug for treating nephropyelitis and a preparation method thereof and belongs to the field of traditional Chinese medicine. The effective components of the drug comprises the following raw materials: reineckia carnea, pinkflush rhododendron root, flos sophora, humifuse euphorbia herb, calcined oyster shell, juniper, apiary, folium sennae, kazinoki papermulberry branchlet and leaf, lygodium japonicum, scandent hop, paederia scandens, fruticose breynia juvenile branchlet and leaf, witloof, lignum et folium trachelospermi and india lovegrass. The drug and the preparation method thereof have the benefits that the medicinal materials selected for the drug are appropriate in compatibility; the drug conforms to the theory of traditional Chinese medicine and the theory of modern medicine and has the efficacies of opening the inhibited lung-energy and inducing diuresis, eliminating wetness and treating stranguria, and cooling blood and detoxifying; the drug has obvious treatment effects on the nephropyelitis, so that patients with pyelonephritis get rid of the pain; the drug has the advantages of no recurrence after recovery, safety and reliability, no toxic and side effect and low cost, and the purpose of treating both symptoms and root causes can be achieved; the drug is worthy of being widely popularized and applied clinically.

Description

A kind of medicine and preparation method for the treatment of pyelonephritis
Art
The present invention relates to the field of Chinese medicines, particularly relate to a kind of medicine and preparation method for the treatment of pyelonephritis.
Background technology
Pyelonephritis refers to renal pelvis inflammation, is mostly caused by bacteriological infection, and pyelonephritis is also known as upper urinary tract infection, and general companion's lower urinary tract inflammation, not easily strictly distinguishes clinically.According to clinical disease course and disease, pyelonephritis can be divided into acute and chronic two phases, and chronic pyelonephritis is the major reason causing chronic renal insufficiency.The multiple women being born in the childbearing age of acute pyelonephritis, patient often has lumbago, kidney district tenderness, kowtows pain, accompanies shiver with cold, generates heat, the General Symptomies such as headache, nausea and vomiting, and the bladder irritation such as urine urgency-frequency and dysurea is levied, and the visible leukocyte of blood count increases.General without hypertension or azotemia.Patient urine is muddy, and can have gross hematuria, routine urinalysis microscopy has volume leukocyte or pus cell, can have a little erythrocyte and cast, and albumen is a little to moderate.
Complicated clinical manifestation during chronic pyelonephritis, easy recurrent exerbation, comparatively acute stage, gently, can show as silent urine to symptom sometimes.Patient more than half has acute pyelonephritis history of past illness, has thereafter weak, low grade fever, anorexia and soreness of waist lumbago shape, and with lower urinary tract irritations such as frequent micturition, urgent micturition, dysureas.Occur when acute attack shows also.The course of disease was exceeded half a year or 1 year person for chronic pyelonephritis, proposing renal pelvis renal calices in recent years has cicatrization in the past, and intravenous urography sees the distortion of renal pelvis renal calices, hydrops, kidney profile are rough, or two inequality in size of kidneys just claim chronic pyelonephritis.Can have renal tubulounterstitial function injure, as concentrating function goes down, hypotonic, low-gravity urine, nocturia increases and renal tubular acidosis etc.To late period, can occur that glomerular function damages, azotemia is until uremia.Renal hypertension is much caused by chronic pyelitis, it is generally acknowledged that the release of patient's high-renin mass formed by blood stasis and some vasoconstrictive polypeptide and sclerosis of blood vessels, the pathological changes such as narrow are relevant.After the sick kidney in small number of patients excision side, hypertension is improved.
Pyelonephritis is a kind of commonly encountered diseases, and sickness rate is very high, and serious threat people's is healthy, and the Western medicine for the treatment of nephritis is many especially at present, but treatment is how not thorough, and side effect is very large, easily recurs, is mostly to cure the symptoms, not the disease.For current medicine Problems existing, through clinical practice for many years, have studied a kind for the treatment of by Chinese herbs pyelonephritis medicine.
Summary of the invention
The invention provides a kind of medicine and preparation method for the treatment of pyelonephritis; Selected by medicine of the present invention, medical material compatibility is suitable, meet Chinese medicine and pharmacy and modern medicine theory, and there is lung qi dispersing diuresis, dampness removing is treating stranguria, effect of removing pathogenic heat from blood and toxic substance from the body, to treatment pyelonephritis there is significant curative effect, make pyelonephritis patient break away from misery, non-relapse after healing, safe and reliable, have no side effect, with low cost, the object for the treatment of both the principal and secondary aspects of a disease can be reached, wide popularization and application on clinic.
For achieving the above object, technical scheme of the present invention is implemented as follows:
Treat a medicine for pyelonephritis, raw material composition and the parts by weight of making described effective ingredient are:
Raw material composition and the parts by weight of making described effective ingredient are:
Raw material composition and the parts by weight of making described effective ingredient are:
Raw material composition and the parts by weight of making described effective ingredient are:
Treat a preparation method for the medicine of pyelonephritis, comprise following processing step:
(1) Herba Reineckeae Carneae, Radix Rhododendri, Juniperus rigida Sieb.et Zucc., Folium Sennae, Folium et Cacumen Broussonetiae Kazinoki, Spora Lygodii, fevervine, Folium et cacumen Breyniae Fruticosae, Spora Lygodii grass and Herba Eragrostidis pilosae are cleaned, put into container, add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, being condensed into relative density at 60 DEG C is the thick paste of 1.10 ~ 1.13, for subsequent use;
(2) Flos Sophorae is put into pot, intense fire is fried to micro-Huang, and taking-up cools, and grinds into powder, crosses 200 order fine powders, for subsequent use.
(3) Herba Euphorbiae Humifusae and Herba Cichorii are cleaned, immerse the alcohol solution dipping 1 ~ 2 hour of 80% of 5 times amount, heating extraction 3 hours, reclaim ethanol, filter, obtain filtrate, at simmer down to 65 DEG C, relative density is the thick paste of 1.12 ~ 1.16, for subsequent use;
(4) Concha Ostreae (calcined) and Nidus Vespae are put into container, carry out pulverization process, grind into powder, cross 180 order fine powders, for subsequent use;
(5) cleaned by Herba humuli scandentis, chopping, puts into container, strand juice, and filter impurity, stays juice for subsequent use;
(6) by thick paste, fine powder and the juice mixing obtained by above-mentioned steps (1) ~ (5), make tablet, obtain the medicine for the treatment of pyelonephritis of the present invention.
The property of medicine of the present invention's Chinese medicine used is as follows:
Herba Reineckeae Carneae: sweet in the mouth, property is put down.Nourishing the lung to arrest cough, synthetism of dispeling the wind.For pulmonary tuberculosis, cough spitting of blood, chronic bronchitis, asthma, rheumatic arthritis; Traumatic injury is controlled in external, fracture." conventional Chinese herbal medicine handbook " carries: " nourishing the lung to arrest cough, the kidney invigorating synthetism.Control pulmonary tuberculosis cough, spit blood, asthma, chronic pyelonephritis, seminal emission, traumatic injury, fracture.”
Radix Rhododendri: bitter in the mouth, cool in nature; GUIXIN, urinary bladder channel.Heat clearing away, diuresis.Main infantile convulsion, flu, acute and chronic nephritis, pyelonephritis.
Flos Sophorae: bitter in the mouth, cold nature; Enter liver, lung, the heart, large intestine channel.Cooling blood for hemostasis, liver heat removing and eyesight improving.Cure mainly discharging fresh blood stool, hemorrhoid hematochezia, dysentery, hematuria, stranguria with blood, metrorrhagia, spit blood, epistaxis, liver-heat is had a headache, conjunctival congestion and swelling pain, carbuncle skin infection." book on Chinese herbal medicine just " carries: " cool large intestine kills infantile malnutrition worm.Control skin sore, erosion of vulva pruritus due to damp pathogen, anal fistula, separate Fructus Myricae rubrae malignant boil, primary sore volt poison." modern medicine study confirms, the globulariacitrin contained by Flos Sophorae can strengthen capillary resistance, improves blood vessel wall fragility, reduces blood pressure, edema, hypertension is had to the effect preventing rupture of blood vessel in brain, also has antiinflammatory action in addition.
Herba Euphorbiae Humifusae: acrid in the mouth, property is put down; Return lung, liver, stomach, large intestine, urinary bladder channel.Heat-clearing and toxic substances removing, dampness removing jaundice eliminating, promoting blood circulation and hemostasis.Cure mainly dysentery, have loose bowels, jaundice, hemoptysis, spit blood, hematuria, has blood in stool, metrorrhagia, agalactia, treating swelling and pain by traumatic injury and pathopyretic ulcer." Chinese herbal medicine is commonly used in Shanghai " carries: " hemostasis, diuresis, stomach invigorating, promoting blood circulation and detoxication.Harness the Yellow River subcutaneous ulcer, dysentery, diarrhoea, urinary tract infection, has blood in stool, hematuria, metrorrhagia, bleeding hemorrhoids, treating swelling and pain by traumatic injury, woman's galactostasis, venom, head sore, skin sore.”
Concha Ostreae (calcined): salty in the mouth, cold nature; Enter liver, kidney channel.Suppressing the hyperactive liver and subsiding YANG, tranquillization with heavy prescription, hard masses softening and resolving, restrains astringent or styptic treatment for spontaneous sweating.Cure mainly vertigo and tinnitus, palpitation with fear insomnia, scrofula goiter ， WEIJIA mass in the abdomen.Compendium of Material Medica is carried: " resolving phlegm and softening hard masses, removing damp-heat, only heart temper pain, under dysentery, reddish and whitish turbid urine, the hernia that disappears abdominal mass amasss block, wart disease tuberculosis." modern medicine study confirmation, Concha Ostreae (calcined) has convergence, calmness, removing toxic substances, analgesic effect, and acidic extraction thing has inhibitory action to poliovirus.
Juniperus rigida Sieb.et Zucc.: sweet in the mouth, hardship, property is put down.To dispel the wind analgesia, dehumidifying diuresis.Main rheumatic arthritis, gout, nephritis, edema, urinary tract infection, formula is with still controlling brucellosis.
Nidus Vespae: sweet in the mouth, property is put down; Return stomach warp.Dispel the wind counteracting toxic substances, parasite killing pain relieving, antiallergic." choosing of Simao, Yunnan Chinese herbal medicine " carries: " relaxing muscles and tendons and activating QI and blood in the collateral, method rheumatism, diuresis.Cure mainly rheumatic arthritis, waist knee joint arthralgia chiefly caused by damp pathogen, oedema due to nephritis." modern medicine study confirmation, Nidus Vespae preparation has the effect promoting Immune Function.
Folium Sennae: sweet in the mouth, hardship, cold in nature, slightly poisonous; Return large intestine channel.The row that purges heat is stagnant, relieving constipation diuretic.Stagnate for accumulation of heat, constipation is suffered from abdominal pain, edema distension.Modern medicine study confirms, Folium Sennae immersion has inhibitory action to various bacteria, as escherichia coli, Bacillus proteus, dysentery bacterium, alpha streptococcus and Candida albicans and some pathogenic dermatophytes.
Folium et Cacumen Broussonetiae Kazinoki: sweet in the mouth, light, property is put down; Return liver, kidney, urinary bladder channel.Dispel the wind, invigorate blood circulation, diuresis.Dispelling the wind and dampness pathogens arthralgia pain, traumatic injury, edema due to deficiency, dermatitis.Jinhua " conventional Chinese herbal folk proved recipe a collection of selected materials " is carried: " expelling wind and activating blood circulation, removing toxic substances diuresis.Dispelling the wind and dampness pathogens arthralgia pain, bubon.”
Spora Lygodii: sweet in the mouth, cold in nature; Return bladder, small intestine meridian.Eliminating damp-heat, treating stranguria pain relieving.For pyretic stranguria, sand Stranguria, stranguria with blood, stranguria marked by chyluria, Urethra astringent pain." Jiangxi medical herbs " carries: " heat-clearing and toxic substances removing, promoting urination to remove dampness.Treating the liver is scorching, renal edema, skin eczema, chickenpox, hematuria.Mumps, acute toothache, throat moth, diphtheria, herpes zoster, children's L infantile malnutrition." modern medicine confirmation, Spora Lygodii decoct all has inhibitory action to staphylococcus aureus, bacillus pyocyaneus, shigella flexneri, Bacillus typhi etc., and Spora Lygodii also has choleretic effect.
Herba humuli scandentis: sweet in the mouth, hardship, cold in nature; Return lung, kidney channel.Heat-clearing and toxic substances removing, inducing diuresis to remove edema.For pulmonary tuberculosis hectic fever, gastroenteritis, dysentery, cold, fever, dysuria, pyelonephritis, acute nephritis, cystitis, urinary system calculus; Carbuncle furuncle and phyma poison is controlled in external, eczema, venom." Anhui medical material " carries: " control insomnia, wash hemorrhoid.”
Fevervine: sweet in the mouth, micro-hardship, property is put down.Expelling wind and removing dampness, promoting digestion and removing stagnation, cough-relieving pain relieving.For bones and muscles pain due to rheumatism, traumatic injury, traumatic pain, liver and gall, gastrointestinal angor, icterohepatitis, enteritis, dysentery, dyspepsia, infantile malnutrition, hemoptysis of pulmonary tuberculosis, bronchitis, the leukopenia that radiation reaction causes, pesticide intoxication; Dermatitis is controlled in external, eczema, sore swollen toxin.
Folium et cacumen Breyniae Fruticosae: mildly bitter flavor, cool in nature.Slightly poisonous.Heat-clearing and toxic substances removing, dissipating blood stasis, pain relieving, antipruritic.Acute gastroenteritis, tonsillitis, bronchitis, lithangiuria, puerperal uterine contraction pain, rheumatic arthritis; Burn and scald is controlled in external, eczema, allergic dermatitis, skin itching, vaginitis." Luchuan book on Chinese herbal medicine " carries: " heat-clearing and toxic substances removing, antidiarrheal, removing mass.Control abdominal pain due to damp-heat, diarrhoea, the arthroncus of knee, treating swelling and pain by traumatic injury.”
Herba Cichorii: bitter in the mouth, salty, cold in nature.Liver heat removing function of gallbladder promoting, invigorating the stomach and promoting digestion, heat-clearing and toxic substances removing, inducing diuresis to remove edema.Cure mainly jaundice due to damp-heat, oedema due to nephritis, epigastric distending pain, inappetence, for jaundice due to damp-heat, stomachache lack of appetite, edema oliguria.Pharmacological evaluation shows, the ethanol of root of Herba Cichorii or ether extract have antibacterial, astriction.
Spora Lygodii grass: sweet in the mouth, micro-hardship, cold in nature.Clearing away heat-damp and promoting diuresis, relaxing muscles and tendons and activating QI and blood in the collateral, hemostasis.Cure mainly urinary tract infection, lithangiuria, oedema due to nephritis, hepatitis, dysentery, conjunctival congestion and swelling pain, rheumatic arthralgia, muscles and bones is numb, injury and bone fracture, traumatic hemorrhage.
Herba Eragrostidis pilosae: sweet in the mouth, light, cool in nature.Inducing diuresis for treating stranguria syndrome, heat clearing and blood circulation promoting.Cure mainly pyretic stranguria, stranguria caused by urinary stone, conjunctival congestion is itched bitterly, traumatic injury." Chinese herbal medicine handbook is commonly used in northeast " carries: " cure mainly urinary tract infection, pyelonephritis.”
The present invention compared with prior art, has following beneficial effect:
Selected by medicine of the present invention, medical material compatibility is suitable, meet Chinese medicine and pharmacy and modern medicine theory, and there is lung qi dispersing diuresis, dampness removing is treating stranguria, effect of removing pathogenic heat from blood and toxic substance from the body, to treatment pyelonephritis there is significant curative effect, make pyelonephritis patient break away from misery, non-relapse after healing, safe and reliable, have no side effect, with low cost, the object for the treatment of both the principal and secondary aspects of a disease can be reached, wide popularization and application on clinic.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The raw material composition of effective ingredient of the present invention and weight are:
Treat a preparation method for the medicine of pyelonephritis, comprise following processing step:
(1) Herba Reineckeae Carneae, Radix Rhododendri, Juniperus rigida Sieb.et Zucc., Folium Sennae, Folium et Cacumen Broussonetiae Kazinoki, Spora Lygodii, fevervine, Folium et cacumen Breyniae Fruticosae, Spora Lygodii grass and Herba Eragrostidis pilosae are cleaned, put into container, add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, being condensed into relative density at 60 DEG C is the thick paste of 1.10 ~ 1.13, for subsequent use;
(2) Flos Sophorae is put into pot, intense fire is fried to micro-Huang, and taking-up cools, and grinds into powder, crosses 200 order fine powders, for subsequent use.
(3) Herba Euphorbiae Humifusae and Herba Cichorii are cleaned, immerse the alcohol solution dipping 1 ~ 2 hour of 80% of 5 times amount, heating extraction 3 hours, reclaim ethanol, filter, obtain filtrate, at simmer down to 65 DEG C, relative density is the thick paste of 1.12 ~ 1.16, for subsequent use;
(4) Concha Ostreae (calcined) and Nidus Vespae are put into container, carry out pulverization process, grind into powder, cross 180 order fine powders, for subsequent use;
(5) cleaned by Herba humuli scandentis, chopping, puts into container, strand juice, and filter impurity, stays juice for subsequent use;
(6) by thick paste, fine powder and the juice mixing obtained by above-mentioned steps (1) ~ (5), make tablet, obtain the medicine for the treatment of pyelonephritis of the present invention.
Usage and dosage: oral, every day 2 times, each 1 time sooner or later, each 2 (every sheet 0.5g), warm water delivery service after meal; Within 9 days, be 1 course for the treatment of, 2 ~ 3 courses for the treatment of can fully recover, and the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.Embodiment 2
The raw material composition of effective ingredient of the present invention and weight are:
The process for preparing medicine processing step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 3
The raw material composition of effective ingredient of the present invention and weight are:
The process for preparing medicine processing step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 4
The raw material composition of effective ingredient of the present invention and weight are:
The process for preparing medicine processing step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 5
The raw material composition of effective ingredient of the present invention and weight are:
The process for preparing medicine processing step of the present embodiment and usage and dosage identical with embodiment 1.
Clinical data:
1, case selection:
As the medicine for the treatment of pyelonephritis, select the routine clinical observation of pyelonephritis patient 254 of making a definite diagnosis, patient is divided into treatment group and matched group two groups at random, treatment group 127 example, wherein male 63 example, women 64 example, 23 ~ 58 years old age, 40.5 years old mean age, average course of disease 2 years; Matched group 127 example, wherein male 64 example, women 63 example, 22 ~ 57 years old age, 39.5 years old mean age, average course of disease 2 years.
The course of disease, the degrees of symptoms for the treatment of group and matched group two groups of cases are basically identical, without significant difference, have comparability.
2, medicament selection:
Treatment group takes medicine of the present invention, oral, every day 2 times, each 1 time sooner or later, each 2 (every sheet 0.5g), warm water delivery service after meal; Within 9 days, be 1 course for the treatment of, 2 ~ 3 courses for the treatment of can fully recover, and the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Matched group uses piperacillin-sulbactam sodium, intravenous drip.Be grown up each 2.5g or 5g (i.e. piperacillin 2g or 4g sulbactam 0.5g or 1g), and within every 8 hours, once renal insufficiency person takes the circumstances into consideration to adjust dosage; The course for the treatment of: 7 ~ 14 days, or need to adjust the course for the treatment of according to the state of an illness.
3, efficacy determination:
(1) cure: clinical symptoms all disappears, and graft function is normal.
(2) effective: clinical symptoms obviously alleviates, renal function is clearly better.
(3) effective: clinical symptoms alleviates to some extent, and renal function takes a turn for the better to some extent.
(4) invalid: by treating rear above-mentioned symptom without alleviating or increasing the weight of.
4, result:
Above result display, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.
Model case is illustrated:
1, Wei, man, 25 years old, people from Jilin Baishan.Patient's persistence microscopic hematuria, frequent recurrent exerbation gross hematuria, suffers from pyelonephritis on inspection, and through taking Drug therapy of the present invention, after taking 1 course for the treatment of, symptom is alleviated to some extent, after continuing to take 2 courses for the treatment of, transference cure, recovery from illness.
2, Xue, female, 31 years old, people from Hengshui, Hebei.Patient suffers from chronic pyelonephritis 3 years, time light time heavy, recurrent exerbation, shallow complexion, the soreness of waist pain, heavy sensation of the body edema, lower limb more so, physical fatigue and lassitude of spirit, insomnia and dreamful sleep, tongue is white, and thready pulse without strength, used multiple method to treat, bad during fashion, fail to eradicate, through using Drug therapy of the present invention, after taking 1 curative effect, symptom obviously alleviates, and after continuing to take 2 courses for the treatment of, all diseases must be removed, chemical examination is normal, and disease obtains recovery from illness, follows up a case by regular visits to and does not recur so far.
3, leaf, man, 37 years old, Heze City, Shandong Province people.Patient clinical is diagnosed as chronic pyelonephritis, ardor unine, dripping not to the utmost, lumbar and back pain, thirsty, red tongue, slippery and rapid pulse, urine check, albumen (+++), red, leukocytosis, gives Drug therapy of the present invention, after treating 1 course for the treatment of, symptom alleviates to some extent, after taking 2 courses for the treatment of of medicine of the present invention, uroscopy normally, transference cure, recovery from illness, follows up a case by regular visits to after 1 year and has no recurrence.
4, the Yan, female, 40 years old, Huainan, Anhui people.Patient suffers from acute nephritis, after this edema, dizzy, lumbago recurrent exerbation, and once twice was chronic nephritis through hospital diagnosis; Face and whole body severe edema time medical, complexion Guang is white, and lassitude, lazy speech, dizziness and blurred vision, coldness of the body with chills, whole body distending pain, waist soreness, oliguria color are clear, amenorrhea 1 year half.White and greasy fur, body of the tongue is purple, there are petechia, deep and hesitant pulse in limit, by Drug therapy of the present invention, after taking 1 course for the treatment of, spirit takes a turn for the better, hydrouria, edema alleviates, waist and extremities joint cold type of pain, after taking 2 courses for the treatment of, diagnosis menstrual onset, edema disappears substantially, and waist and extremities joint cold type of pain take a turn for the better, after continuing to take 1 course for the treatment of, further consultation: General Symptoms disappears, urine chemical examination is normal, recovery from illness.
5, Pan, man, 45 years old, Jinhua, Zhejiang people.Patient's urine frequently anxious burning pain hematuria, lumbago, fever, dizziness, edema, flushed face, red tongue, yellow and thin fur, rapid breathing, wiry and frequent pulse chi moistens number, urine examination: the full visual field of erythrocyte, leukocyte 8 ~ 10, albumen (+++) is diagnosed as acute nephritis, take Drug therapy of the present invention, after taking 1 course for the treatment of; urine frequently anxious burning pain subtracts most; hematuria disappearance, and edema also disappears most, after continuing to take 1 course for the treatment of; urine transfers to normally; edema disappears, all disease knowing are removed, and uroscopy also normally, is followed up a case by regular visits to after 2 years and do not recurred.
6, remaining certain, female, 53 years old, yueyang, hunan people.Continuous 6 ~ 8 urine of patient's readme are with blood in all urinating, and total urination time increases, urgent micturition, indagation body temperature 38.5 DEG C, also have obvious lumbago, are diagnosed as pyelonephritis with hematuria.Take Drug therapy of the present invention, after taking 1 course for the treatment of, symptom takes an evident turn for the better, and after taking 2 courses for the treatment of of medicine of the present invention, hematuria and simultaneous phenomenon disappear.

Claims (5)

1. treat a medicine for pyelonephritis, it is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:
Herba Reineckeae Carneae 44 ~ 68 parts of Radix Rhododendris 42 ~ 66 parts of Flos Sophoraes 41 ~ 65 parts of Herba Euphorbiae Humifusaes 41 ~ 65 parts
Concha Ostreae (calcined) 40 ~ 64 portions of Juniperus rigida Sieb.et Zucc. 39 ~ 63 parts of Nidus Vespae 39 ~ 63 portions of Folium Sennae 38 ~ 62 parts
Folium et Cacumen Broussonetiae Kazinoki 38 ~ 62 parts of Spora Lygodii 36 ~ 60 parts of Herba humuli scandentis 35 ~ 59 parts of fevervines 35 ~ 59 parts
Folium et cacumen Breyniae Fruticosae 33 ~ 57 portions of Herba Cichoriis 32 ~ 56 parts of Spora Lygodii grass 29 ~ 53 parts of Herba Eragrostidis pilosaees 24 ~ 48 parts.
2. a kind of medicine for the treatment of pyelonephritis according to claim 1, is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:
Herba Reineckeae Carneae 48 ~ 64 parts of Radix Rhododendris 46 ~ 62 parts of Flos Sophoraes 45 ~ 61 parts of Herba Euphorbiae Humifusaes 45 ~ 61 parts
Concha Ostreae (calcined) 44 ~ 60 portions of Juniperus rigida Sieb.et Zucc. 43 ~ 59 parts of Nidus Vespae 43 ~ 59 portions of Folium Sennae 42 ~ 58 parts
Folium et Cacumen Broussonetiae Kazinoki 42 ~ 58 parts of Spora Lygodii 40 ~ 56 parts of Herba humuli scandentis 39 ~ 55 parts of fevervines 39 ~ 55 parts
Folium et cacumen Breyniae Fruticosae 37 ~ 53 portions of Herba Cichoriis 36 ~ 52 parts of Spora Lygodii grass 33 ~ 49 parts of Herba Eragrostidis pilosaees 28 ~ 44 parts.
3. a kind of medicine for the treatment of pyelonephritis according to claim 1, is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:
Herba Reineckeae Carneae 52 ~ 60 parts of Radix Rhododendris 50 ~ 58 parts of Flos Sophoraes 49 ~ 57 parts of Herba Euphorbiae Humifusaes 49 ~ 57 parts
Concha Ostreae (calcined) 48 ~ 56 portions of Juniperus rigida Sieb.et Zucc. 47 ~ 55 parts of Nidus Vespae 47 ~ 55 portions of Folium Sennae 46 ~ 54 parts
Folium et Cacumen Broussonetiae Kazinoki 46 ~ 54 parts of Spora Lygodii 44 ~ 52 parts of Herba humuli scandentis 43 ~ 51 parts of fevervines 43 ~ 51 parts
Folium et cacumen Breyniae Fruticosae 41 ~ 49 portions of Herba Cichoriis 40 ~ 48 parts of Spora Lygodii grass 37 ~ 45 parts of Herba Eragrostidis pilosaees 32 ~ 40 parts.
4. a kind of medicine for the treatment of pyelonephritis according to claim 1, is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:
Herba Reineckeae Carneae 56 parts of Radix Rhododendris 54 parts of Flos Sophoraes 53 parts of Herba Euphorbiae Humifusaes 53 parts
Concha Ostreae (calcined) 52 portions of Juniperus rigida Sieb.et Zucc. 51 parts of Nidus Vespae 51 portions of Folium Sennae 50 parts
Folium et Cacumen Broussonetiae Kazinoki 50 parts of Spora Lygodii 48 parts of Herba humuli scandentis 47 parts of fevervines 47 parts
Folium et cacumen Breyniae Fruticosae 45 portions of Herba Cichoriis 44 parts of Spora Lygodii grass 41 parts of Herba Eragrostidis pilosaees 36 parts.
5. as described in any one of Claims 1 to 4, treat a preparation method for the medicine of pyelonephritis, it is characterized in that: comprise following processing step:
(1) Herba Reineckeae Carneae, Radix Rhododendri, Juniperus rigida Sieb.et Zucc., Folium Sennae, Folium et Cacumen Broussonetiae Kazinoki, Spora Lygodii, fevervine, Folium et cacumen Breyniae Fruticosae, Spora Lygodii grass and Herba Eragrostidis pilosae are cleaned, put into container, add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, being condensed into relative density at 60 DEG C is the thick paste of 1.10 ~ 1.13, for subsequent use;
(2) Flos Sophorae is put into pot, intense fire is fried to micro-Huang, and taking-up cools, and grinds into powder, crosses 200 order fine powders, for subsequent use;
(3) Herba Euphorbiae Humifusae and Herba Cichorii are cleaned, immerse the alcohol solution dipping 1 ~ 2 hour of 80% of 5 times amount, heating extraction 3 hours, reclaim ethanol, filter, obtain filtrate, at simmer down to 65 DEG C, relative density is the thick paste of 1.12 ~ 1.16, for subsequent use;
(4) Concha Ostreae (calcined) and Nidus Vespae are put into container, carry out pulverization process, grind into powder, cross 180 order fine powders, for subsequent use;
(5) cleaned by Herba humuli scandentis, chopping, puts into container, strand juice, and filter impurity, stays juice for subsequent use;
(6) by thick paste, fine powder and the juice mixing obtained by above-mentioned steps (1) ~ (5), make tablet, obtain the medicine of described treatment pyelonephritis.
CN201410525744.5A 2014-09-30 2014-09-30 Drug for treating nephropyelitis and preparation method thereof Pending CN104258151A (en)

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104758706A (en) * 2015-04-24 2015-07-08 王立昌 Traditional Chinese medicine preparation for treating nephropyelitis and preparation method of traditional Chinese medicine preparation
CN104771558A (en) * 2015-04-24 2015-07-15 王立昌 Traditional Chinese medicine composition for treating nephritis and preparation method of traditional Chinese medicine composition
CN104800504A (en) * 2015-04-24 2015-07-29 王立昌 Traditional Chinese medicine preparation for treating nephritis and preparation method
CN104800631A (en) * 2015-04-24 2015-07-29 王立昌 Traditional Chinese medicine composition for treating pyelonephritis and preparation method thereof
CN105770519A (en) * 2016-03-05 2016-07-20 席敦香 Medicine for treating hydronephrosis and preparation method

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
刘平等: "《百花调治百病》", 31 August 2012, 金盾出版社 *
宋卫国: "肾盂肾炎中医证治进度", 《江西中医药》 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104758706A (en) * 2015-04-24 2015-07-08 王立昌 Traditional Chinese medicine preparation for treating nephropyelitis and preparation method of traditional Chinese medicine preparation
CN104771558A (en) * 2015-04-24 2015-07-15 王立昌 Traditional Chinese medicine composition for treating nephritis and preparation method of traditional Chinese medicine composition
CN104800504A (en) * 2015-04-24 2015-07-29 王立昌 Traditional Chinese medicine preparation for treating nephritis and preparation method
CN104800631A (en) * 2015-04-24 2015-07-29 王立昌 Traditional Chinese medicine composition for treating pyelonephritis and preparation method thereof
CN105770519A (en) * 2016-03-05 2016-07-20 席敦香 Medicine for treating hydronephrosis and preparation method

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