CN101264204A - Chinese medicinal composition for inhibiting uric acid and treating gout and preparation thereof - Google Patents
Chinese medicinal composition for inhibiting uric acid and treating gout and preparation thereof Download PDFInfo
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- CN101264204A CN101264204A CNA200810105038XA CN200810105038A CN101264204A CN 101264204 A CN101264204 A CN 101264204A CN A200810105038X A CNA200810105038X A CN A200810105038XA CN 200810105038 A CN200810105038 A CN 200810105038A CN 101264204 A CN101264204 A CN 101264204A
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Abstract
The invention discloses a Chinese herbal medicine composition to refrain uric acid and cure gout and the preparation method. The active ingredients in the invention are extracted from cornus officinalis, Chinese yam, peach kernel, poria cocos, Oriental Waterplantain Rhizome, rhizomadrynariae, notopterygium, angelica sinensis, cyathula root, Japanese teasel, angelica, red peony root, notoginseng, schisandra, pangolin, prepared rhizome of rehmanniae and cortex moutan. The special medical active components in the invention can reinforce blood oxygen metabolism, improve the forming of converting enzyme, correct purine metabolic disorder and quickly refrain the forming of uric acid.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine pharmacy, be specifically related to a kind of Chinese medicine composition that suppresses uric acid and treating gout and preparation method thereof.
Technical background
Gout is long-term purine metabolism obstacle, and blood uric acid increases the one group of disease that causes tissue injury.Secular blood uric acid increases, can be in the joint itself and surrounding tissue deposition, cause gouty arthritis, the joint of the big nurse toe of the most normal infringement of gout root, but also be common in sufficient other position, knee joint, carpal joint, finger-joint and elbow joint.Visceral lesion also can take place in gout patient, and modal is that uric acid causes gouty nephropathy and gout renal calculus in the kidney deposition.
Gout is a kind of chronic lifelong property disease, and the course of disease is many decades, and has the intermittently characteristics of outbreak, can be the same when not showing effect with the normal person, and patient is often and pay no attention to.The cause of gout is a hyperuricemia, and the reason by hyperuricemia forms can be divided into gout constitutional and Secondary cases two classes.Primary gout accounts for the overwhelming majority, is about more than 90%, and certain familial inheritance tendency is arranged.The gout pilosity is born in middle-aged and elderly people, overweight people and brain worker.
A kind of material that is purine is arranged in human body, after its metabolism gets muddled, will cause gout.Purine is through a series of metabolic alterations, and the final product that forms is acid.Uric acid does not have assorted the one physiological function in human body, under normal circumstances, the uric acid 2/3 that produces in the body is discharged by kidney, and 1/3 is discharged by large intestine.Intravital uric acid is constantly to generate and draining, so it keeps certain concentration in blood.In the synthetic and catabolic process of purine, the participation of plurality of enzymes is arranged, because the birth defect metabolism of enzyme gets muddled, the full one-tenth increase or the discharge of uric acid are reduced, all can cause hyperuricemia.When the blood uric acid excessive concentration, uric acid promptly is deposited in joint, soft tissue, cartilage and the kidney with the form of sodium salt, causes the seed of trouble that the thing inflammatory reaction has become to cause gout of leading of tissue.Thoroughly can not cause ecchymosis around arthroncus, deformity, stiff, the joint, tuberosity, concurrent gouty renal calculus, gouty renal failure as treatment, internal organs diseases such as gouty coronary heart disease, hyperlipidemia, hypertension, urinary system calculus threaten patient's life directly to cause the termination of life.
The present invention is the crystallization of traditional traditional Chinese medical science and modern science and technology, utilize the active biomolecule in the ingredients to activate neurocyte, strengthen the formation of blood oxygen metabolism, increase " conversion enzyme ", correct purine metabolic disturbance, the formation that suppresses uric acid rapidly stops the heavily absorption of renal tubules to uric acid, promotes the drainage of renal tubules to uric acid.
Summary of the invention:
One of purpose of the present invention provides a kind of Chinese medicine composition that suppresses uric acid and treating gout.
Another object of the present invention provides the preparation method of this Chinese medicine composition.
Chinese medicine of the present invention is made up of active ingredient and/or pharmaceutically acceptable carrier, and wherein said active ingredient is made (part is unit of weight) by following raw materials according:
1. write out a prescription:
Fructus Corni 100-300 part Rhizoma dioscoreae (parched) 100-300 part Semen Persicae 100-300 part
Poria 100-300 part Rhizoma Alismatis 100-300 part Rhizoma Drynariae 100-300 part
Rhizoma Et Radix Notopterygii 100-300 part Radix Angelicae Sinensis 100-300 part Radix Achyranthis Bidentatae 100-300 part
Radix Dipsaci 100-300 part Radix Angelicae Dahuricae 100-300 part Radix Paeoniae Rubra 100-300 part
Radix Notoginseng 100-300 part Fructus Schisandrae Chinensis 100-300 part Squama Manis 100-300 part
Radix Rehmanniae Preparata 100-300 part Cortex Moutan 100-300 part
The active component that preferred following raw materials according is made, curative effect is better:
200 parts in 150 parts of Semen Persicaes of 200 parts of Rhizoma dioscoreae (parched)s of Fructus Corni
150 parts of 150 parts of Rhizoma Drynariae of 150 portions of Rhizoma Alismatis of Poria
150 parts of 200 parts of Radix Achyranthis Bidentataes of 100 parts of Radix Angelicae Sinensis of Rhizoma Et Radix Notopterygii
150 parts of 150 parts of Radix Paeoniae Rubra of 150 parts of Radixs Angelicae Dahuricae of Radix Dipsaci
100 parts of 200 parts of Squama Maniss of 100 parts of Fructus Schisandrae Chinensis of Radix Notoginseng
100 parts of 150 parts of Cortex Moutans of Radix Rehmanniae Preparata
The active ingredient preparation method of Chinese medicine of the present invention can be that raw material is dry respectively, and levigation mixes.It also can be the conventional method preparation of adopting herbal pharmaceutical.These pharmacy conventional methods can be water extract-alcohol precipitation or ethanol extract from water precipitation, also have other extracting method in addition, specifically " pharmaceutics of Chinese drugs " published referring to Cao Chunlin chief editor's Shanghai science tech publishing house.
The following preparation method preparation of preferred employing:
2. preparation technology
(1) Radix Angelicae Sinensis, Fructus Schisandrae Chinensis add 80% alcohol dipping three times, flood 48 hours for the first time, and second and third time flooded respectively 24 hours, filter, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) medical materials such as all the other Fructus Corni, Rhizoma dioscoreae (parched), Semen Persicae, Poria, Rhizoma Alismatis, Rhizoma Drynariae, Rhizoma Et Radix Notopterygii, Radix Achyranthis Bidentatae, Radix Dipsaci, the Radix Angelicae Dahuricae, Radix Paeoniae Rubra, Radix Notoginseng, Squama Manis, Radix Rehmanniae Preparata, Cortex Moutan add 10 times of decoctings and boil three times, 1 hour for the first time, second and third time 0.5 hour, filter, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, be ground into fine powder, add acceptable accessories and make different preparations such as granule, sheet, capsule.
By the following examples technical scheme of the present invention is described further.
Embodiment 1: the preparation method of granule
1. write out a prescription:
200 parts in 150 parts of Semen Persicaes of 200 parts of Rhizoma dioscoreae (parched)s of Fructus Corni
150 parts of 150 parts of Rhizoma Drynariae of 150 portions of Rhizoma Alismatis of Poria
150 parts of 200 parts of Radix Achyranthis Bidentataes of 100 parts of Radix Angelicae Sinensis of Rhizoma Et Radix Notopterygii
150 parts of 150 parts of Radix Paeoniae Rubra of 150 parts of Radixs Angelicae Dahuricae of Radix Dipsaci
100 parts of 200 parts of Squama Maniss of 100 parts of Fructus Schisandrae Chinensis of Radix Notoginseng
100 parts of 150 parts of Cortex Moutans of Radix Rehmanniae Preparata
2. preparation technology
(1) Radix Angelicae Sinensis, Fructus Schisandrae Chinensis add 80% alcohol dipping three times, flood 48 hours for the first time, and second and third time flooded respectively 24 hours, filter, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) medical materials such as all the other Fructus Corni, Rhizoma dioscoreae (parched), Semen Persicae, Poria, Rhizoma Alismatis, Rhizoma Drynariae, Rhizoma Et Radix Notopterygii, Radix Achyranthis Bidentatae, Radix Dipsaci, the Radix Angelicae Dahuricae, Radix Paeoniae Rubra, Radix Notoginseng, Squama Manis, Radix Rehmanniae Preparata, Cortex Moutan add 10 times of decoctings and boil three times, 1 hour for the first time, second and third time 0.5 hour, filter, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, add cane sugar powder, mixing is made granule, drying, promptly.
Embodiment 2: the preparation method of tablet
1. write out a prescription:
200 parts in 150 parts of Semen Persicaes of 200 parts of Rhizoma dioscoreae (parched)s of Fructus Corni
150 parts of 150 parts of Rhizoma Drynariae of 150 portions of Rhizoma Alismatis of Poria
150 parts of 200 parts of Radix Achyranthis Bidentataes of 100 parts of Radix Angelicae Sinensis of Rhizoma Et Radix Notopterygii
150 parts of 150 parts of Radix Paeoniae Rubra of 150 parts of Radixs Angelicae Dahuricae of Radix Dipsaci
100 parts of 200 parts of Squama Maniss of 100 parts of Fructus Schisandrae Chinensis of Radix Notoginseng
100 parts of 150 parts of Cortex Moutans of Radix Rehmanniae Preparata
2. preparation technology
(1) Radix Angelicae Sinensis, Fructus Schisandrae Chinensis add 80% alcohol dipping three times, flood 48 hours for the first time, and second and third time flooded respectively 24 hours, filter, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) medical materials such as all the other Fructus Corni, Rhizoma dioscoreae (parched), Semen Persicae, Poria, Rhizoma Alismatis, Rhizoma Drynariae, Rhizoma Et Radix Notopterygii, Radix Achyranthis Bidentatae, Radix Dipsaci, the Radix Angelicae Dahuricae, Radix Paeoniae Rubra, Radix Notoginseng, Squama Manis, Radix Rehmanniae Preparata, Cortex Moutan add 10 times of decoctings and boil three times, 1 hour for the first time, second and third time 0.5 hour, filter, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, pulverize, sieve, add starch, magnesium stearate, tabletting, promptly.
Embodiment 3: the preparation method of capsule
1. write out a prescription:
200 parts in 150 parts of Semen Persicaes of 200 parts of Rhizoma dioscoreae (parched)s of Fructus Corni
150 parts of 150 parts of Rhizoma Drynariae of 150 portions of Rhizoma Alismatis of Poria
150 parts of 200 parts of Radix Achyranthis Bidentataes of 100 parts of Radix Angelicae Sinensis of Rhizoma Et Radix Notopterygii
150 parts of 150 parts of Radix Paeoniae Rubra of 150 parts of Radixs Angelicae Dahuricae of Radix Dipsaci
100 parts of 200 parts of Squama Maniss of 100 parts of Fructus Schisandrae Chinensis of Radix Notoginseng
100 parts of 150 parts of Cortex Moutans of Radix Rehmanniae Preparata
2. preparation technology
(1) Radix Angelicae Sinensis, Fructus Schisandrae Chinensis add 80% alcohol dipping three times, flood 48 hours for the first time, and second and third time flooded respectively 24 hours, filter, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) medical materials such as all the other Fructus Corni, Rhizoma dioscoreae (parched), Semen Persicae, Poria, Rhizoma Alismatis, Rhizoma Drynariae, Rhizoma Et Radix Notopterygii, Radix Achyranthis Bidentatae, Radix Dipsaci, the Radix Angelicae Dahuricae, Radix Paeoniae Rubra, Radix Notoginseng, Squama Manis, Radix Rehmanniae Preparata, Cortex Moutan add 10 times of decoctings and boil three times, 1 hour for the first time, second and third time 0.5 hour, filter, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, pulverize, sieve, add starch, mixing is made granule, and drying incapsulates, promptly.
Claims (5)
1, a kind of Chinese medicine composition that suppresses uric acid and treating gout is characterized in that being made up of active ingredient and/or pharmaceutically acceptable carrier, and wherein said active ingredient is made by following raw materials according:
Fructus Corni 100-300 part Rhizoma dioscoreae (parched) 100-300 part Semen Persicae 100-300 part
Poria 100-300 part Rhizoma Alismatis 100-300 part Rhizoma Drynariae 100-300 part
Rhizoma Et Radix Notopterygii 100-300 part Radix Angelicae Sinensis 100-300 part Radix Achyranthis Bidentatae 100-300 part
Radix Dipsaci 100-300 part Radix Angelicae Dahuricae 100-300 part Radix Paeoniae Rubra 100-300 part
Radix Notoginseng 100-300 part Fructus Schisandrae Chinensis 100-300 part Squama Manis 100-300 part
Radix Rehmanniae Preparata 100-300 part Cortex Moutan 100-300 part.
2, a kind of Chinese medicine composition that suppresses uric acid and treating gout according to claim 1 is characterized in that wherein preparing the preferred following raw materials according of described active ingredient:
200 parts in 150 parts of Semen Persicaes of 200 parts of Rhizoma dioscoreae (parched)s of Fructus Corni
150 parts of 150 parts of Rhizoma Drynariae of 150 portions of Rhizoma Alismatis of Poria
150 parts of 200 parts of Radix Achyranthis Bidentataes of 100 parts of Radix Angelicae Sinensis of Rhizoma Et Radix Notopterygii
150 parts of 150 parts of Radix Paeoniae Rubra of 150 parts of Radixs Angelicae Dahuricae of Radix Dipsaci
100 parts of 200 parts of Squama Maniss of 100 parts of Fructus Schisandrae Chinensis of Radix Notoginseng
100 parts of 150 parts of Cortex Moutans of Radix Rehmanniae Preparata.
3, according to the described a kind of Chinese medicine composition that suppresses uric acid and treating gout of claim 1-2, it is characterized in that adopting following method to make:
(1) Radix Angelicae Sinensis, Fructus Schisandrae Chinensis add 80% alcohol dipping three times, flood 48 hours for the first time, and second and third time flooded respectively 24 hours, filter, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) medical materials such as all the other Fructus Corni, Rhizoma dioscoreae (parched), Semen Persicae, Poria, Rhizoma Alismatis, Rhizoma Drynariae, Rhizoma Et Radix Notopterygii, Radix Achyranthis Bidentatae, Radix Dipsaci, the Radix Angelicae Dahuricae, Radix Paeoniae Rubra, Radix Notoginseng, Squama Manis, Radix Rehmanniae Preparata, Cortex Moutan add 10 times of decoctings and boil three times, 1 hour for the first time, second and third time 0.5 hour, filter, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, be ground into fine powder, add acceptable accessories and make different preparations such as granule, sheet, capsule.
4, according to any one described a kind of Chinese medicine composition that suppresses uric acid and treating gout among the claim 1-3, it is characterized in that this Chinese medicine composition is an oral formulations.
5, according to the described a kind of Chinese medicine composition that suppresses uric acid and treating gout of claim 3-4, it is characterized in that this Chinese medicine composition can be made into granule, capsule, tablet.
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| Application Number | Priority Date | Filing Date | Title |
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| CNA200810105038XA CN101264204A (en) | 2008-04-25 | 2008-04-25 | Chinese medicinal composition for inhibiting uric acid and treating gout and preparation thereof |
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| CNA200810105038XA CN101264204A (en) | 2008-04-25 | 2008-04-25 | Chinese medicinal composition for inhibiting uric acid and treating gout and preparation thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102665725A (en) * | 2009-12-21 | 2012-09-12 | 狮王株式会社 | Hyperlipemia-ameliorating agent, anemia-ameliorating composition, uric-acid-level-reducing composition, and foods and beverages |
| CN103705812A (en) * | 2014-01-16 | 2014-04-09 | 郝应芬 | Medicine composition for treating gout and preparation method and application thereof |
| CN104042893A (en) * | 2014-06-30 | 2014-09-17 | 邹金林 | Traditional Chinese medicine preparation for treating gout and preparation method of traditional Chinese medicine preparation |
| CN110522864A (en) * | 2019-08-16 | 2019-12-03 | 马仁宝 | A kind of Chinese materia medica preparation for goat |
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2008
- 2008-04-25 CN CNA200810105038XA patent/CN101264204A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102665725A (en) * | 2009-12-21 | 2012-09-12 | 狮王株式会社 | Hyperlipemia-ameliorating agent, anemia-ameliorating composition, uric-acid-level-reducing composition, and foods and beverages |
| US8927033B2 (en) | 2009-12-21 | 2015-01-06 | Lion Corporation | Hyperlipemia-ameliorating agent, anemia-ameliorating composition, uric-acid-level-reducing composition, and food or beverage |
| CN102665725B (en) * | 2009-12-21 | 2015-04-22 | 狮王株式会社 | Hyperlipemia-ameliorating agent, anemia-ameliorating composition, uric-acid-level-reducing composition, and foods and beverages |
| CN103705812A (en) * | 2014-01-16 | 2014-04-09 | 郝应芬 | Medicine composition for treating gout and preparation method and application thereof |
| CN104042893A (en) * | 2014-06-30 | 2014-09-17 | 邹金林 | Traditional Chinese medicine preparation for treating gout and preparation method of traditional Chinese medicine preparation |
| CN110522864A (en) * | 2019-08-16 | 2019-12-03 | 马仁宝 | A kind of Chinese materia medica preparation for goat |
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Open date: 20080917 |