CN1107517C - Antiabortifacient for treating acyesis and sterility and its preparing process - Google Patents
Antiabortifacient for treating acyesis and sterility and its preparing process Download PDFInfo
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- CN1107517C CN1107517C CN 00117145 CN00117145A CN1107517C CN 1107517 C CN1107517 C CN 1107517C CN 00117145 CN00117145 CN 00117145 CN 00117145 A CN00117145 A CN 00117145A CN 1107517 C CN1107517 C CN 1107517C
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Abstract
The present invention provides a medicine for promoting pregnancy and a preparation method thereof. The medicine is used for treating the barrenness of men and women. The medicine of the present invention is prepared from medical raw material components of 15 traditional Chinese medicines of peach seed, hemlock parsley, angelica, nutgrass galingale rhizome, cassia twig, epimedium, dodder, radix dipsaci from Sichuan of China, wild ginger, radices paeoniae rubra, dioscorea root, matrimony vine, amethyst, twotoothed achyranthes root, radix glycyrrhiza, etc. The preparation method provided by the present invention is in accordance with the regulations of a Chinese pharmacopoeia. The medicine of the present invention is proved to have the functions and the efficacy of invigorating the kidney, replenishing essence, activating blood circulation and nourishing blood through clinical use, and is suitable for the barrenness of men and women caused by symptoms of amenorrhea, irregular menses, metrorrhagia and metrostaxis, intermenstrual bleeding, oligospermatism, etc. which are caused by renal deficiency and insufficiency of vital energy and blood.
Description
The wood invention relates to a kind of pregnancy promoting medicine for the treatment of man's and woman's sterility, and specifically belonging to the Chinese herbal medicine is the Chinese patent medicine of raw material, the invention still further relates to the preparation method of this medicine.
Infertility is meant under the situation of not taking any contraceptives, gestation arranged after the normality life more than 2 years yet or life birth person is arranged.Chinese medicine is accumulating rich experience aspect the treatment man's and woman's sterility, as Li Yunxiao based on the kidney invigorating, " the palace electuary is educated in the kidney invigorating " that assistant is formed with the liver benefiting replenishing essence, nourshing blood and promoting blood circulation medicine, form by 13 flavor medicines such as harts horn carbon, Fructus Corni, the Cortex Eucommiae, structure Qi, Radix Salviae Miltiorrhizae, Radix Rehmanniae Preparata, Fluoritum, treatment uterine hypoplasia infertility (relation of uterine hypoplasia infertility and Chinese medical discrimination typing, journal of shanghai Chinese medicine 1998;＜8 〉: 40～41); Guan Xinmei uses the induced ovulation soup based on invigorating kidney, promoting blood circulation class Chinese medicine, its basic side is: Radix Rehmanniae Preparata, Semen Cuscutae, Herba Epimedii, Herba Cistanches, Fructus Schisandrae Chinensis, Cornu Cervi Degelatinatum, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae etc., treatment ovulatory dysfunction sterility (induced ovulation soup treatment ovulatory dysfunction barrenness 29 examples, traditional Chinese medical science research 1998; 11＜4 〉: 37～38).Above-mentioned Chinese medicine is paid attention to the tonifying liver the kidney invigorating not embodying whole the executing of seeing of the traditional Chinese medical science and controlling principle to cure infertility, uses the tonic of a large amount of the kidney invigorating tonifying livers in the side, is difficult for absorbing, and gets angry easily after eating, and curative effect is limited.
The objective of the invention is the existing problem of Chinese medicine of curing infertility at existing, proposes a kind of efficient, effect is wide, nature and flavor are gentle, be difficult for getting angry, be easy to the pregnancy promoting medicine and preparation method thereof of the treatment man's and woman's sterility of oral and absorption.
The present invention is based on and suffer from a deficiency of the kidney and the three dirty imbalances of liver spleen are the understanding that causes the mechanism of infertility, the rule of treatment of corresponding formulation " reinforce the kidney, spleen invigorating, accent liver and be in harmonious proportion three dirty ", select and " nature and flavor " compatibility according to medicine " return through ", select in kidney channel, spleen channel, the Liver Channel that clinical efficacy is good, effect is strong for use, have respectively reinforce the kidney, the Chinese medicine of spleen invigorating, accent liver, the purify composition of each medicine of refine is made the pregnancy promoting medicine of this treatment man's and woman's sterility.
Medicine of the present invention is made (consumption is a weight portion) by following component;
4.5～10 parts in Semen Persicae, 3～10 parts of Rhizoma Chuanxiongs, 4.5～15 parts of Radix Angelicae Sinensis, 6～12 parts of Rhizoma Cyperis, 3～10 parts of Ramulus Cinnamomi, 3～10 parts of Herba Epimedii, 10～15 parts of Semen Cuscutae, 6～12 parts of Radix Dipsaci, 1.5～3 parts of Herba Asaris, 4.5～15 parts of Radix Paeoniae Rubra, 15～30 parts of Rhizomadioscoreae, 6～12 parts of Fructus Lyciis, 6～12 parts of Fluoritum, 4.5～15 parts of Radix Achyranthis Bidentataes, 2～10 parts in Radix Glycyrrhizae.
The preferred weight proportioning of preparation pharmaceutical formulation of the present invention is:
10 parts in Semen Persicae, 8 parts of Rhizoma Chuanxiongs, 12 parts of Radix Angelicae Sinensis, 10 parts of Rhizoma Cyperis, 8 parts of Ramulus Cinnamomi, 10 parts of Herba Epimedii, 15 parts of Semen Cuscutae, 10 parts of Radix Dipsaci, 3 parts of Herba Asaris, 15 parts of Radix Paeoniae Rubra, 20 parts of Rhizomadioscoreae, 10 parts of Fructus Lyciis, 6 parts of Fluoritum, 10 parts of Radix Achyranthis Bidentataes, 5 parts in Radix Glycyrrhizae.
The dosage form of medicine of the present invention can be capsule or pill.
The preparation method of making medicine of the present invention comprises following processing step:
(1) Fluoritum, Ramulus Cinnamomi, Radix Dipsaci, Radix Achyranthis Bidentatae, Herba Epimedii, Herba Asari, Fructus Lycii, Radix Glycyrrhizae 8 flavor medicines shred respectively in the side of getting, and mix, earlier with 80～100 ℃ of hot water lixiviates, with adding ethanol after the extract filtering and concentrating to containing alcohol 70%, leave standstill, filter, behind the filtrate recycling ethanol, be condensed into thick paste;
(2) Semen Persicae in the side of getting, Rhizoma Cyperi, Semen Cuscutae, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Rhizomadioscoreae, Radix Angelicae Sinensis 7 flavor medicated powder are broken into coarse powder, with 70% ethanol percolation, collect 5 times of amounts of medicinal liquid behind the mixing, and filtration behind the filtrate recycling ethanol, is condensed into thick paste;
(3) merge above-mentioned two kinds of thick pastes, mixing, vacuum drying becomes dry extract, pulverizes, and crosses 80～100 mesh sieves;
(4) with above-mentioned gained medicated powder filled capsules, be the capsule-type dosage form; The medicated powder of above-mentioned gained is added water and honey, make piller, be pill.
For improving the extraction ratio of each medicine composition, in above-mentioned steps (1), described 8 flavor medicines will be used hot water lixiviate secondary, the amount of water of each lixiviate is 10～12 times of doses (weight), each extraction time is no less than 2 hours, the extract filtering and concentrating adds to leave standstill behind the ethanol and is no less than 48 hours, and then filters, reclaims ethanol, is condensed into thick paste.
Fluoritum, Semen Cuscutae, Herba Epimedii, Rhizomadioscoreae, the kidney invigorating of Radix Dipsaci the kidney warming among the side of the present invention, spleen invigorating helps the fortune hemopoietic, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Rhizoma Cyperi, Semen Persicae, Herba Asari, Radix Paeoniae Rubra, Radix Achyranthis Bidentatae, Ramulus Cinnamomi nourishing blood and promoting blood circulation, warming the meridian is regulated the flow of vital energy, the Fructus Lycii nourishing kidney is nourished blood, Radix Glycyrrhizae mediation thread medicine is played kidney tonifying, essence replenishing altogether, is in harmonious proportion and dashes the merit of appointing.The present invention's flavour of a drug of writing out a prescription are gentle, can not get angry after eating.
Preparation method of the present invention, the composition of refine purification material medicine, method for making meets the Chinese Pharmacopoeia regulation, and capsule of making or pill are easy to absorb and are oral, help improving curative effect.
Medicine of the present invention proves that this poison of drug is very low, clinical consumption safety through the animal acute toxicity test of Traditional Chinese Medicine University Of Guangzhou's taste institute;
All by the check of Shantou City medicine inspecting institute, the result meets the requirements for the capsule that the present invention makes, pill.
Medicine of the present invention shows to have the effect and the effect of kidney tonifying, essence replenishing, nourishing blood and promoting blood circulation through clinical use, is adapted to amenorrhea, menoxenia, metrorrhagia, intermenstrual bleeding, few essence, azoospermia etc., and card belongs to the man's and woman's sterility of the double insufficiency of vital energy and blood of suffering from a deficiency of the kidney.
Be the curative effect of proof medicine of the present invention, the present invention in Shantou City, Guangdong institute of traditional Chinese medicine to belonging to: A, amenorrhea companion endogenous estrogen are in level follicular phase; B, hypomenorrhea, menstruation irregularis, menstruation rule but the infertility case of two kinds of situations such as anovulation (are got rid of; 1, FSH raises; 2, ovulation is arranged; 3, ovary and pituitary tumor; 4, the anatomic abnormalities of sexual reproduction organ and non-gonad endocrinopathy person) carry out clinical treatment test, oral medicine of the present invention, and to select the suitable patient of symptom be matched group, does the contrast observation with other existing Chinese and western drugses treatments.Curative effect determinate standard: become pregnant and can keep 4 months no spontaneous abortions for curing in the wife's side; Have only the ovulation reaction not have and become pregnant, or the back spontaneous abortion of becoming pregnant is effectively; The anovulation reaction is for invalid.The judgement of ovulation standard occurs 2 above person's decidables of following situation simultaneously and is ovulation: 1, gestation; 2, BBT two-phase; 3, serial B ultrasonic monitoring has growing follicle and ovulation; 4, BBT rises and surveyed blood E on the 7th day
2, P reaches level luteal phase.Clinical trial divides three groups to carry out observation of curative effect and research, and every group of each 32 example were treated 6 months, and the result is as follows:
1, takes medicine of the present invention (capsule or pill), treat 32 examples, cure 21 examples, effective 8 examples, invalid 3 examples.Effective percentage 90.17%;
2, take Western medicine CC, treat 32 examples, cure 11 examples, effective 12 examples, invalid 9 examples.Effective percentage 71.9%;
3, take medicine of the present invention and add Western medicine CC, treat 32 examples, cure 22 examples, effective 9 examples, invalid 1 example.Effective percentage 96.9%.
Can find out that from above-mentioned clinical test results curative effect of medication of the present invention is good, not only using separately has better curative effect, can cooperate with Western medicine CC again and take, to produce better effect.This medicinal flavor is gentle, is difficult for getting angry, and can uninterruptedly take medicine, and is efficient, easily absorbs selection easy for patients to accept.
Embodiment one
Take by weighing raw material by following proportioning:
10 kilograms in Semen Persicae, 8 kilograms of Rhizoma Chuanxiongs, 12 kilograms of Radix Angelicae Sinensis, 10 kilograms of Rhizoma Cyperis, 8 kilograms of Ramulus Cinnamomi, 10 kilograms of Herba Epimedii, 15 kilograms of Semen Cuscutae, 10 kilograms of Radix Dipsaci, 3 kilograms of Herba Asaris, 15 kilograms of Radix Paeoniae Rubra, 20 kilograms of Rhizomadioscoreae, 10 kilograms of Fructus Lyciis, 6 kilograms of Fluoritum, 10 kilograms of Radix Achyranthis Bidentataes, 5 kilograms in Radix Glycyrrhizae.
Preparation method is as follows:
(1) Fluoritum, Ramulus Cinnamomi, Radix Dipsaci, Radix Achyranthis Bidentatae, Herba Epimedii, Herba Asari, Fructus Lycii, Radix Glycyrrhizae 8 flavor medicines are cut respectively, are pulverized in the side of getting, and mix, and described 8 flavor medicines add 12 times of amounts of water, and heated and boiled was collected medicinal liquid after 2 hours; Medicinal residues are added 10 times of amounts of water again, and heated and boiled was collected medicinal liquid after 2 hours; The medicinal liquid of twice collection is merged, filter, be condensed into 1: 1 extractum, put cold back and add ethanol, left standstill 48 hours, and then filter, reclaim ethanol, be condensed into thick paste (30 ℃ are surveyed relative density 1.20～1.25) to containing alcohol 70%;
(2) Semen Persicae in the side of getting, Rhizoma Cyperi, Semen Cuscutae, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Rhizomadioscoreae, Radix Angelicae Sinensis 7 flavor medicated powder are broken into coarse powder, with 70% ethanol percolation, collect 5 times of amounts of medicinal liquid behind the mixing, filtration, and behind the filtrate recycling ethanol, vacuum concentration becomes thick paste;
(3) merge above-mentioned two kinds of thick pastes, mixing, rebasing with Pulvis Talci, become dry extract in vacuum drying (below 80 ℃), pulverize, cross 80 mesh sieve secondaries, be filled in " 0 " number capsule, i.e. cost capsule formulation medicine.
Made capsule character: its content is a sepia medicated powder, and mildly bitter flavor is puckery.
This product usage and dosage is: every capsules contains active ingredient 600mg, and once oral 4, every day three times, or follow the doctor's advice.
Embodiment two
Take by weighing raw material by following proportioning:
5 kilograms in Semen Persicae, 5 kilograms of Rhizoma Chuanxiongs, 8 kilograms of Radix Angelicae Sinensis, 5 kilograms of Rhizoma Cyperis, 3 kilograms of Ramulus Cinnamomi, 8 kilograms of Herba Epimedii, 10 kilograms of Semen Cuscutae, 10 kilograms of Radix Dipsaci, 1 kilogram of Herba Asari, 10 kilograms of Radix Paeoniae Rubra, 10 kilograms of Rhizomadioscoreae, 10 kilograms of Fructus Lyciis, 6 kilograms of Fluoritum, 8 kilograms of Radix Achyranthis Bidentataes, 3 kilograms in Radix Glycyrrhizae.
Its preparation method (1), (2) two steps are identical with embodiment one, and (3) goes on foot and to become piller with processed with honey for prepared medicated powder is added water, pill medicine of the present invention.
Made pill character: be light, rounding, the uniform brownish black piller of color and luster, ball heart taupe, feeble QI perfume (or spice), sweet in the mouth, hardship, suffering, little one-tenth.
Claims (5)
1. pregnancy promoting medicine for the treatment of infertility is characterized in that it is the medicament of being made by the following weight proportion raw material:
4.5～10 parts in Semen Persicae, 3～10 parts of Rhizoma Chuanxiongs, 4.5～15 parts of Radix Angelicae Sinensis, 6～12 parts of Rhizoma Cyperis, 3～10 parts of Ramulus Cinnamomi, 3～10 parts of Herba Epimedii, 10～15 parts of Semen Cuscutae, 6～12 parts of Radix Dipsaci, 1.5～3 parts of Herba Asaris, 4.5～15 parts of Radix Paeoniae Rubra, 15～30 parts of Rhizomadioscoreae, 6～12 parts of Fructus Lyciis, 6～12 parts of Fluoritum, 4.5～15 parts of Radix Achyranthis Bidentataes, 2～10 parts in Radix Glycyrrhizae.
2. pregnancy promoting medicine according to claim 1 is characterized in that wherein the weight proportion of each raw material is:
10 parts in Semen Persicae, 8 parts of Rhizoma Chuanxiongs, 12 parts of Radix Angelicae Sinensis, 10 parts of Rhizoma Cyperis, 8 parts of Ramulus Cinnamomi, 10 parts of Herba Epimedii, 15 parts of Semen Cuscutae, 10 parts of Radix Dipsaci, 3 parts of Herba Asaris, 15 parts of Radix Paeoniae Rubra, 20 parts of Rhizomadioscoreae, 10 parts of Fructus Lyciis, 6 parts of Fluoritum, 10 parts of Radix Achyranthis Bidentataes, 5 parts in Radix Glycyrrhizae.
3. pregnancy promoting medicine according to claim 1 and 2, the dosage form that it is characterized in that said medicament is capsule or pill.
4. the preparation method of the described pregnancy promoting medicine of claim 3 is characterized in that step of preparation process is as follows:
(1) Fluoritum, Ramulus Cinnamomi, Radix Dipsaci, Radix Achyranthis Bidentatae, Herba Epimedii, Herba Asari, Fructus Lycii, Radix Glycyrrhizae 8 flavor medicines shred respectively in the side of getting, and mix, earlier with 80～100 ℃ of hot water lixiviates, with adding ethanol after the extract filtering and concentrating to containing alcohol 70%, leave standstill, filter, behind the filtrate recycling ethanol, be condensed into thick paste;
(2) Semen Persicae in the side of getting, Rhizoma Cyperi, Semen Cuscutae, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Rhizomadioscoreae, Radix Angelicae Sinensis 7 flavor medicated powder are broken into coarse powder, with 70% ethanol percolation, collect 5 times of amounts of medicinal liquid behind the mixing, and filtration behind the filtrate recycling ethanol, is condensed into thick paste;
(3) merge above-mentioned two kinds of thick pastes, mixing, vacuum drying becomes dry extract, pulverizes, and crosses 80～100 mesh sieves;
(4) with above-mentioned gained medicated powder filled capsules, be the capsule-type dosage form; The medicated powder of above-mentioned gained is added water and honey, make piller, be pill.
5. the preparation method of pregnancy promoting medicine according to claim 4, it is characterized in that in the step (1), the medicinal hot water lixiviate secondary of described 8 flavors, the amount of water of each lixiviate is 10～12 times of doses (weight), each extraction time is no less than 2 hours, the extract filtering and concentrating adds to leave standstill behind the ethanol and is no less than 48 hours, and then filters, reclaims ethanol, is condensed into thick paste.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00117145 CN1107517C (en) | 2000-06-08 | 2000-06-08 | Antiabortifacient for treating acyesis and sterility and its preparing process |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00117145 CN1107517C (en) | 2000-06-08 | 2000-06-08 | Antiabortifacient for treating acyesis and sterility and its preparing process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1327818A CN1327818A (en) | 2001-12-26 |
| CN1107517C true CN1107517C (en) | 2003-05-07 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 00117145 Expired - Fee Related CN1107517C (en) | 2000-06-08 | 2000-06-08 | Antiabortifacient for treating acyesis and sterility and its preparing process |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101502634B (en) * | 2009-03-06 | 2011-11-02 | 陈殿红 | Chinese medicinal composition for treating uterine blood flow and preparation method thereof |
| CN102836382B (en) * | 2012-10-09 | 2013-09-04 | 彭少芳 | Kidney-tonifying and embryo-developing externally-applied plaster |
| CN102949664B (en) * | 2012-11-13 | 2014-05-07 | 刘晓燕 | Traditional Chinese medicinal composite for treating fallopian-tube obstructive infertility |
| CN105343433A (en) * | 2015-12-11 | 2016-02-24 | 董娟 | Traditional Chinese medicine composition capable of promoting ovulation |
| CN105748816A (en) * | 2016-05-04 | 2016-07-13 | 颜景玲 | Medicine for treating fallopian tube obstruction |
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| Publication number | Publication date |
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| CN1327818A (en) | 2001-12-26 |
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