CN1124143C - Pregnancy promoting medicine for treating hyperprolactinemia sterility and its preparation - Google Patents
Pregnancy promoting medicine for treating hyperprolactinemia sterility and its preparation Download PDFInfo
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- CN1124143C CN1124143C CN 00114035 CN00114035A CN1124143C CN 1124143 C CN1124143 C CN 1124143C CN 00114035 CN00114035 CN 00114035 CN 00114035 A CN00114035 A CN 00114035A CN 1124143 C CN1124143 C CN 1124143C
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Abstract
The present invention provides a pregnancy promoting medicine for treating hyperprolactinemia barrenness and a preparation method thereof. The pregnancy promoting medicine of the present invention comprises the raw materials of traditional Chinese medicinal materials such as malt, haw, red sage root, beautiful sweetgum fruit, red peony root, mint, bupleurum root, angelica, cortex moutan, cape jasmine fruit, ophiopogon root, epimedium, tuckahoe, matrimony vine, licorice root, etc. The present invention provides a preparation method which accords with the Chinese pharmacopeia specification. Clinical operation indicates that the pregnancy promoting medicine of the present invention can inhibit blood PRL and regulate hormones E, T or P, etc. The pregnancy promoting medicine has the characteristics of convenience, cheapness, efficaciousness, no toxic or side reaction, has the efficiency of soothing the liver, tonifying the kidney and strengthening the spleen, and is a high efficiency concentrated traditional Chinese medicine for treating barrenness due to HPRL.
Description
The present invention relates to a kind of medicine for the treatment of man's and woman's sterility, specifically belonging to the Chinese herbal medicine is the Chinese patent medicine of raw material, the invention still further relates to the preparation method of this medicine.
Hyperprolactinemia (HPRL) is a kind of hypothalamus-gonad axis disease, mainly shows as galactorrhea, sexual dysfunction, menoxenia, amenorrhea and sterility and infertility.Check multiple existing ovulation failure, serum prolactin antagonist (PRL) raises.Because of it disturbs the gonad endocrine axis, can suppress ovulation and cause infertile; Can suppress the ripe hormone (FSH) of human follicle-stimulating, human luteinizing hormone (LH) to influence testicular spermatogenic function again and cause sterile, so one of HPRL infertility that to be the men and women common.Chinese medicine is accumulating rich experience aspect the treatment man's and woman's sterility, existing a lot of Chinese medicine and proved recipes of curing infertility are using on the present tcm clinical practice, these Chinese medicines are all than paying attention to the tonifying liver the kidney invigorating to cure infertility, and are undesirable to the infertility curative effect that HPRL disease causes.
The objective of the invention is to propose a kind of infertility that treatment hyperprolactinemia (HPRL) is caused medicine of satisfactory effect and preparation method thereof is arranged.
The present invention according to HPRL based on stagnation of liver-QI, suffer from a deficiency of the kidney or the insufficiency of the spleen Chinese medicine dialectical analysis of seeing more, the rule of treatment of corresponding formulation " reinforce the kidney, spleen invigorating, accent liver and be in harmonious proportion three dirty ", select and " nature and flavor " compatibility according to medicine " return through ", select in kidney channel, spleen channel, the Liver Channel that clinical efficacy is good, effect is strong for use, have respectively reinforce the kidney, the Chinese medicine of spleen invigorating, accent liver, the purify composition of each medicine of refine is made the medicine of this treatment man's and woman's sterility.
Medicine of the present invention is made (consumption is a weight portion) by following component: 5～60 parts in Fructus Hordei Germinatus, 10～30 parts of Fructus Crataegis, 5～15 parts of Radix Salviae Miltiorrhizaes, 6～10 parts of Fructus Liquidambaris, 4.5～15 parts of Radix Paeoniae Rubra, 2～10 parts of Herba Menthaes, 3～15 parts of Radix Bupleuri, 4.5～15 parts of Radix Angelicae Sinensis, 4.5～10 parts of Cortex Moutans, 3～10 parts of Fructus Gardeniaes, 6～12 parts of Radix Ophiopogonis, 3～15 parts of Herba Epimedii, 9～15 parts in Poria, 6～15 parts of Fructus Lyciis, 2～10 parts in Radix Glycyrrhizae.
The preferred weight proportioning of preparation pharmaceutical formulation of the present invention is:
60 parts in Fructus Hordei Germinatus, 30 parts of Fructus Crataegis, 15 parts of Radix Salviae Miltiorrhizaes, 10 parts of Fructus Liquidambaris, 15 parts of Radix Paeoniae Rubra, 3 parts of Herba Menthaes, 10 parts of Radix Bupleuri, 15 parts of Radix Angelicae Sinensis, 10 parts of Cortex Moutans, 10 parts of Fructus Gardeniaes, 10 parts of Radix Ophiopogonis, 15 parts of Herba Epimedii, 15 parts in Poria, 10 parts of Fructus Lyciis, 5 parts in Radix Glycyrrhizae.
The dosage form of medicine of the present invention can be capsule or pill.
The preparation method of making medicine of the present invention comprises following processing step:
(1) Fructus Hordei Germinatus, Herba Menthae, Cortex Moutan, Fructus Liquidambaris, Fructus Lycii, Fructus Gardeniae, Radix Ophiopogonis, Herba Epimedii 8 flavor medicines are cut respectively, are pulverized in the side of getting, and mix, earlier with 80～100 ℃ of hot water lixiviates, with adding ethanol after the extract filtering and concentrating to containing alcohol 70%, leave standstill, filter, behind the filtrate recycling ethanol, be condensed into thick paste;
(2) Fructus Crataegi in the side of getting, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Radix Bupleuri, Radix Angelicae Sinensis, Poria, Radix Glycyrrhizae 7 flavor medicated powder are broken into coarse powder, with 70% ethanol percolation, collect 5 times of amounts of medicinal liquid behind the mixing, and filtration behind the filtrate recycling ethanol, is condensed into thick paste;
(3) merge above-mentioned two kinds of thick pastes, mixing, vacuum drying becomes dry extract, pulverizes, and crosses 80～100 mesh sieves;
(4) with above-mentioned gained medicated powder filled capsules, be the capsule-type dosage form; The medicated powder of above-mentioned gained is added water and honey, make piller, be pill.
For improving the extraction ratio of each medicine composition, in above-mentioned steps (1), described 8 flavor medicines will be used hot water lixiviate secondary, the amount of water of each lixiviate is 10～12 times of doses (weight), each extraction time is no less than 2 hours, the extract filtering and concentrating adds to leave standstill behind the ethanol and is no less than 48 hours, and then filters, reclaims ethanol, is condensed into thick paste.
Medicine provided by the present invention has the merit of transferring liver, the kidney invigorating, and the effect that has significant reduction and regulate PRL.The traditional Chinese medical science is thought: the generation of HPRL is main relevant with liver, spleen kidney three dirty functional disorders, depression of liver-QI, or dampness-heat of the liver or anger upper punch, and the then contrary unrest of QI-blood circulation does not follow Chang Jing, instead turns to milk with going into breast on the irritability; The liver and the kidney have a common source, and the liver-yang hyperactivity of suffering from a deficiency of the kidney can not reach catharsis by bar; Insufficiency of the spleen mistake fortune, water is wet to be stopped gathering, blocks vessels of the uterus and all cause qi-blood disharmony, the blood uterus (kidney essense) of can not making a bet, superinverse is a milk on the contrary, as seen liver mistake bar reaches, deficiency of the kidney is insufficiency of the spleen, stagnation of QI-blood, so that the QI and blood disorder is the main etiology and pathogenesis of HPRL, and Gu Fangzhong selects Fructus Hordei Germinatus, Fructus Crataegi, Radix Bupleuri, Fructus Gardeniae, Fructus Liquidambaris depressed liver-energy dispersing and QI regulating for use, presses down newborn pathogenic fire purging; Fructus Lycii, Herba Epimedii adjusting and reinforcing liver and kidney; Poria, Radix Glycyrrhizae spleen invigorating and in; Cortex Moutan, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra blood circulation promoting and blood stasis dispelling, the thread medicine share, and is total to long memorial liver spleen, invigorating kidney, promoting blood circulation, regulates the flow of vital energy and press down the merit of breast.
Preparation method of the present invention, the composition of refine purification material medicine, method for making meets the Chinese Pharmacopoeia regulation, and capsule of making or pill are easy to absorb and are oral, help improving curative effect.
Medicine of the present invention proves that this poison of drug is very low, clinical consumption safety through the animal acute toxicity test of Traditional Chinese Medicine University Of Guangzhou's taste institute;
For verifying the curative effect of the infertility that the high prolactin antagonist of Drug therapy of the present invention causes, in the hospital of traditional Chinese hospital, Shantou City to male and female patient (male 50 people of 100 routine high HPRL infertilities, woman 50 people, the case of getting rid of pituitary PRL adenoma and FSH rising) carries out clinical trial, the experimenter is used medicine of the present invention 3 months, drug withdrawal was followed the trail of 3 months again, prolactin antagonist (PRL), estradiol (E before and after comparative test person treats
2), the variation and the curative effect of testosterone (T) or Progesterone (P), curative effect determinate standard is: cure: blood PRL reduces to normally, checks not recur symptom, sign disappearance person in 3 months; Produce effects: blood PRL descends and reaches below 1/2 of initial value, but still is higher than normal value, symptom, sign improver; Effectively: blood PRL has decline, but does not reach 1/2 of initial value, and is higher than normal value, and symptom, sign are improved not apparent author; Invalid: blood PRL does not have obvious decline, and symptom, sign do not have the improver.Therapeutic outcome shows: cure 31 examples, and produce effects 33 examples, effective 23 examples, invalid 13 examples, cure rate and pregnancy rate are 31%, effective percentage 87%.
Clinical use shows, medicine of the present invention is through suppressing blood PRL and regulating hormones such as E, T or P, be characterized in just, honest and clean, test, do not have toxicity, has merit soothing the liver, kidney and spleen invigorating, be the efficient concentrated traditional Chinese medicine of the infertility that causes of treatment HPRL, the clinical double male and female infertilities of suffering from a deficiency of the kidney of cards genus irritability stasis such as amenorrhea, endometrium ectopia, menoxenia, male sexual disorder, few essence, azoospermia that are applicable to.
Embodiment one
Take by weighing raw material by following proportioning:
3.6 kilograms in Fructus Hordei Germinatus, 1.8 kilograms of Fructus Crataegis, 0.9 kilogram of Radix Salviae Miltiorrhizae, 0.6 kilogram of Fructus Liquidambaris, 0.9 kilogram of Radix Paeoniae Rubra, 0.18 kilogram of Herba Menthae, 0.6 kilogram of Radix Bupleuri, 0.9 kilogram of Radix Angelicae Sinensis, 0.6 kilogram of Cortex Moutan, 0.6 kilogram of Fructus Gardeniae, 0.6 kilogram of Radix Ophiopogonis, 0.9 kilogram of Herba Epimedii, 0.9 kilogram in Poria, 0.9 kilogram of Fructus Lycii, 0,3 kilogram in Radix Glycyrrhizae.
Preparation method is as follows:
(1) Fructus Hordei Germinatus, Herba Menthae, Cortex Moutan, Fructus Liquidambaris, Fructus Lycii, Fructus Gardeniae, Radix Ophiopogonis, Herba Epimedii 8 flavor medicines are cut respectively, are pulverized in the side of getting, and mix, and described 9 flavor medicines add 12 times of amounts of water, and heated and boiled was collected medicinal liquid after 2 hours; Medicinal residues are added 10 times of amounts of water again, and heated and boiled was collected medicinal liquid after 2 hours; The medicinal liquid of twice collection is merged, filter, be condensed into 1: 1 extractum, put cold back and add ethanol, left standstill 48 hours, and then filter, reclaim ethanol, be condensed into thick paste (30 ℃ are surveyed relative density 1.20～1.25) to containing alcohol 70%;
(2) Fructus Crataegi in the side of getting, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Radix Bupleuri, Radix Angelicae Sinensis, Poria, Radix Glycyrrhizae 7 flavor medicated powder are broken into coarse powder, with 70% ethanol percolation, collect 5 times of amounts of medicinal liquid behind the mixing, filtration, and behind the filtrate recycling ethanol, vacuum concentration becomes thick paste;
(3) merge above-mentioned two kinds of thick pastes, mixing, vacuum drying (below 80 ℃) becomes dry extract, pulverizes, and crosses 80 mesh sieve secondaries, is filled in " 0 " number capsule, i.e. cost capsule formulation medicine.
Made capsule character: its content is a sepia medicated powder, and mildly bitter flavor is puckery, tool fragrance.
Embodiment two
Take by weighing raw material by following proportioning:
1.667 kilograms in Fructus Hordei Germinatus, 1.25 kilograms of Fructus Crataegis, 1.25 kilograms of Radix Salviae Miltiorrhizaes, 0.833 kilogram of Fructus Liquidambaris, 0.833 kilogram of Radix Paeoniae Rubra, 0.25 kilogram of Herba Menthae, 1.25 kilograms of Radix Bupleuri, 1.25 kilograms of Radix Angelicae Sinensis, 0.833 kilogram of Cortex Moutan, 0.833 kilogram of Fructus Gardeniae, 0.833 kilogram of Radix Ophiopogonis, 0.833 kilogram of Herba Epimedii, 0.833 kilogram in Poria, 0.833 kilogram of Fructus Lycii, 0,417 kilogram in Radix Glycyrrhizae.
Make the capsule formulation medicine with the method identical with embodiment one.
Embodiment three
Take by weighing raw material by following proportioning:
10 parts in Fructus Hordei Germinatus, 10 parts of Fructus Crataegis, 10 parts of Radix Salviae Miltiorrhizaes, 6 parts of Fructus Liquidambaris, 6 parts of Radix Paeoniae Rubra, 2 parts of Herba Menthaes, 9 parts of Radix Bupleuri, 8 parts of Radix Angelicae Sinensis, 8 parts of Cortex Moutans, 6 parts of Fructus Gardeniaes, 6 parts of Radix Ophiopogonis, 6 parts of Herba Epimedii, 8 parts in Poria, 8 parts of Fructus Lyciis, 3 parts in Radix Glycyrrhizae.
Its preparation method (1), (2) two steps are identical with embodiment one, and (3) goes on foot and to become piller with processed with honey for prepared medicated powder is added water, pill medicine of the present invention.
Made pill character: be light, rounding, the uniform brownish black piller of color and luster, ball heart taupe, feeble QI perfume (or spice), sweet in the mouth, hardship, suffering, little salty.
Claims (5)
1. medicine for the treatment of hyperprolactinemia sterility is characterized in that it is the medicament of being made by the following weight proportion raw material:
5～60 parts in Fructus Hordei Germinatus, 10～30 parts of Fructus Crataegis, 5～15 parts of Radix Salviae Miltiorrhizaes, 6～10 parts of Fructus Liquidambaris, 4.5～15 parts of Radix Paeoniae Rubra, 2～10 parts of Herba Menthaes, 3～10 parts of Radix Bupleuri, 4.5～15 parts of Radix Angelicae Sinensis, 4.5～10 parts of Cortex Moutans, 3～10 parts of Fructus Gardeniaes, 6～12 parts of Radix Ophiopogonis, 3～15 parts of Herba Epimedii, 9～15 parts in Poria, 6～12 parts of Fructus Lyciis, 2～10 parts in Radix Glycyrrhizae.
2. medicine according to claim 1 is characterized in that wherein the weight proportion of each raw material is:
60 parts in Fructus Hordei Germinatus, 30 parts of Fructus Crataegis, 15 parts of Radix Salviae Miltiorrhizaes, 10 parts of Fructus Liquidambaris, 15 parts of Radix Paeoniae Rubra, 3 parts of Herba Menthaes, 10 parts of Radix Bupleuri, 15 parts of Radix Angelicae Sinensis, 10 parts of Cortex Moutans, 10 parts of Fructus Gardeniaes, 10 parts of Radix Ophiopogonis, 15 parts of Herba Epimedii, 15 parts in Poria, 10 parts of Fructus Lyciis, 5 parts in Radix Glycyrrhizae.
3. medicine according to claim 1 and 2, the dosage form that it is characterized in that said medicament is capsule or pill.
4. the preparation method of the described medicine of claim 3 is characterized in that step of preparation process is as follows:
(1) gets Fructus Hordei Germinatus, Herba Menthae, Cortex Moutan, Fructus Liquidambaris, Fructus Lycii, Fructus Gardeniae, Radix Ophiopogonis, Herba Epimedii 8 flavor medicines and cut respectively, pulverize, mix, earlier with 80～100 ℃ of hot water lixiviates, with adding ethanol after the extract filtering and concentrating to containing alcohol 70%, leave standstill, filter, behind the filtrate recycling ethanol, be condensed into thick paste;
(2) get Fructus Crataegi, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Radix Bupleuri, Radix Angelicae Sinensis, Poria, Radix Glycyrrhizae 7 flavor medicated powder and be broken into coarse powder, with 70% ethanol percolation, collect 5 times of amounts of medicinal liquid behind the mixing, filtration behind the filtrate recycling ethanol, is condensed into thick paste;
(3) merge above-mentioned two kinds of thick pastes, mixing, vacuum drying becomes dry extract, pulverizes, and crosses 80～100 mesh sieves;
(4) with above-mentioned gained medicated powder filled capsules, be the capsule-type dosage form; The medicated powder of above-mentioned gained is added water and honey, make piller, be pill.
5. the preparation method of medicine according to claim 4, it is characterized in that in the step (1), the medicinal hot water lixiviate secondary of described 8 flavors, the amount of water of each lixiviate is 10～12 times of doses (weight), each extraction time is no less than 2 hours, the extract filtering and concentrating adds to leave standstill behind the ethanol and is no less than 48 hours, and then filters, reclaims ethanol, is condensed into thick paste.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00114035 CN1124143C (en) | 2000-01-24 | 2000-01-24 | Pregnancy promoting medicine for treating hyperprolactinemia sterility and its preparation |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00114035 CN1124143C (en) | 2000-01-24 | 2000-01-24 | Pregnancy promoting medicine for treating hyperprolactinemia sterility and its preparation |
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| Publication Number | Publication Date |
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| CN1306853A CN1306853A (en) | 2001-08-08 |
| CN1124143C true CN1124143C (en) | 2003-10-15 |
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| CN 00114035 Expired - Fee Related CN1124143C (en) | 2000-01-24 | 2000-01-24 | Pregnancy promoting medicine for treating hyperprolactinemia sterility and its preparation |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103638290A (en) * | 2013-11-26 | 2014-03-19 | 青岛安信医疗器械有限公司 | Traditional Chinese medicine liquid for treating chronic gastritis and preparation method thereof |
| CN104189737A (en) * | 2014-08-12 | 2014-12-10 | 黄太锋 | Traditional Chinese medicine composition for treating hyperprolactinemia |
| CN112587645A (en) * | 2021-01-08 | 2021-04-02 | 湖南省中医药研究院 | Traditional Chinese medicine composition for treating infertility, traditional Chinese medicine preparation and traditional Chinese medicine product |
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