CN112587645A - Traditional Chinese medicine composition for treating infertility, traditional Chinese medicine preparation and traditional Chinese medicine product - Google Patents
Traditional Chinese medicine composition for treating infertility, traditional Chinese medicine preparation and traditional Chinese medicine product Download PDFInfo
- Publication number
- CN112587645A CN112587645A CN202110025885.0A CN202110025885A CN112587645A CN 112587645 A CN112587645 A CN 112587645A CN 202110025885 A CN202110025885 A CN 202110025885A CN 112587645 A CN112587645 A CN 112587645A
- Authority
- CN
- China
- Prior art keywords
- weight
- parts
- content
- chinese medicine
- traditional chinese
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
- A61K36/296—Epimedium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/486—Millettia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/744—Gardenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/746—Morinda
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8964—Anemarrhena
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/90—Smilacaceae (Catbrier family), e.g. greenbrier or sarsaparilla
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Reproductive Health (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a medicament for treating infertility, and discloses a Chinese medicinal composition, a Chinese medicinal preparation and a Chinese medicinal product for treating infertility. The traditional Chinese medicine composition for treating infertility comprises the following components: rhizoma curculiginis, morinda officinalis, herba epimedii, angelica sinensis, phellodendron, rhizoma anemarrhenae, cortex moutan, gardenia, radix bupleuri, radix paeoniae alba, bighead atractylodes rhizome, poria cocos, ginger, mint, cowherb seed, fructus liquidambaris, chinaroot greenbrier, caulis spatholobi and liquorice. The preparation method of the traditional Chinese medicine preparation comprises the following steps: mixing the traditional Chinese medicine components with water, decocting for multiple times, and mixing water extract obtained by each decoction to obtain the traditional Chinese medicine preparation for treating infertility. The traditional Chinese medicine composition disclosed by the invention has the advantages that the yin and yang qi and blood are in biochemical activity, the operation is normal, the yin and yang are coordinated, the kidney can be tonified for pregnancy, and the traditional Chinese medicine composition has a good curative effect on treating infertility.
Description
Technical Field
The invention relates to a medicament for treating infertility, in particular to a traditional Chinese medicine composition, a traditional Chinese medicine preparation and a traditional Chinese medicine product for treating infertility.
Background
With the development of society, the life style and living environment of people are greatly changed, such as the pace of life is accelerated, the mental stress is increased, the environmental pollution is increased, and the like, and the phenomena of infertility also show an increasing trend, so that a plurality of families are troubled by the problem of fertility, and therefore, the study on the infertility is very necessary. The reasons for infertility are various, and women mainly have various factors such as vaginal, cervical and uterine abnormalities, ovarian abnormalities, sexually transmitted diseases, genital tuberculosis, immunological reasons or repeated abortion and the like; the male mainly has the factors of sperm abnormality, sexual dysfunction, reproductive organ abnormality, endocrine abnormality and the like.
At present, the medicines for treating infertility are various, western medicines mainly comprise antibiotics, and are matched with operations, but the root cause of diseases cannot be removed; the clinical treatment effect of a plurality of traditional Chinese medicine formulas is generally not ideal enough, especially the treatment difficulty of infertility caused by immune reasons is larger, and the aim of treating both symptoms and root causes cannot be achieved.
Disclosure of Invention
The invention aims to solve the problem that the infertility in the prior art can not address both the symptoms and root causes, and provides a traditional Chinese medicine composition, a traditional Chinese medicine preparation and a traditional Chinese medicine product for treating infertility.
In order to achieve the above object, a first aspect of the present invention provides a Chinese medicinal composition for treating infertility, which comprises the following components: rhizoma curculiginis, morinda officinalis, herba epimedii, angelica sinensis, phellodendron, rhizoma anemarrhenae, cortex moutan, gardenia, radix bupleuri, radix paeoniae alba, bighead atractylodes rhizome, poria cocos, ginger, mint, cowherb seed, fructus liquidambaris, chinaroot greenbrier, caulis spatholobi and liquorice.
Preferably, relative to 10 parts by weight of the rhizoma curculiginis, the content of the morinda officinalis is 5-15 parts by weight, the content of the epimedium is 5-15 parts by weight, the content of the angelica sinensis is 15-25 parts by weight, the content of the phellodendron bark is 5-15 parts by weight, the content of the rhizoma anemarrhenae is 15-25 parts by weight, the content of the moutan bark is 5-15 parts by weight, the content of the gardenia is 5-15 parts by weight, the content of the bupleurum root is 5-15 parts by weight, the content of the white peony root is 25-35 parts by weight, the content of the bighead atractylodes rhizome is 25-35 parts by weight, the content of the poria cocos is 25-35 parts by weight, the content of the ginger is 5-15 parts by weight, the content of the mint is 5-15 parts by weight, the content of the cowherb seed is 25-35 parts by weight, the sweetgum fruit is 10-20 parts by weight, 25-35 parts of caulis spatholobi and 1-5 parts of liquorice.
Preferably, relative to 10 parts by weight of the rhizoma curculiginis, the content of the morinda officinalis is 8-12 parts by weight, the content of the epimedium is 8-12 parts by weight, the content of the angelica sinensis is 18-22 parts by weight, the content of the phellodendron bark is 8-12 parts by weight, the content of the rhizoma anemarrhenae is 18-22 parts by weight, the content of the moutan bark is 8-12 parts by weight, the content of the gardenia is 8-12 parts by weight, the content of the bupleurum root is 8-12 parts by weight, the content of the white peony root is 28-32 parts by weight, the content of the bighead atractylodes rhizome is 28-32 parts by weight, the content of the poria cocos is 28-32 parts by weight, the content of the ginger is 8-12 parts by weight, the content of the mint is 8-12 parts by weight, the content of the cowherb seed is 28-32 parts by weight, the sweetgum fruit is 13-18 parts by weight, 28-32 parts of caulis spatholobi and 2-4 parts of liquorice.
In a second aspect, the present invention provides a method for preparing a Chinese medicinal preparation for treating infertility, the method comprising the steps of: mixing rhizoma curculiginis, morinda officinalis, epimedium herb, angelica, phellodendron, rhizoma anemarrhenae, moutan bark, gardenia, radix bupleuri, radix paeoniae alba, bighead atractylodes rhizome, poria cocos, ginger, mint, cowherb seed, fructus liquidambaris, chinaroot greenbrier, caulis spatholobi and liquorice with water, decocting for multiple times, and mixing water extract obtained by each decocting to obtain the traditional Chinese medicine preparation for treating infertility.
Preferably, relative to 10 parts by weight of the rhizoma curculiginis, the dosage of the morinda officinalis is 5-15 parts by weight, the dosage of the epimedium is 5-15 parts by weight, the dosage of the angelica is 15-25 parts by weight, the dosage of the phellodendron is 5-15 parts by weight, the dosage of the rhizoma anemarrhenae is 15-25 parts by weight, the dosage of the moutan bark is 5-15 parts by weight, the dosage of the gardenia is 5-15 parts by weight, the dosage of the bupleurum is 5-15 parts by weight, the dosage of the white peony root is 25-35 parts by weight, the dosage of the atractylodes macrocephala is 25-35 parts by weight, the dosage of the poria cocos is 25-35 parts by weight, the dosage of the ginger is 5-15 parts by weight, the dosage of the mint is 5-15 parts by weight, the dosage of the cowherb seed is 25-35 parts by weight, the sweetgum fruit is 10-20 parts by weight, the dosage of, 25-35 parts of caulis spatholobi and 1-5 parts of liquorice;
preferably, relative to 10 parts by weight of the rhizoma curculiginis, the dosage of the morinda officinalis is 8-12 parts by weight, the dosage of the epimedium is 8-12 parts by weight, the dosage of the angelica is 18-22 parts by weight, the dosage of the phellodendron is 8-12 parts by weight, the dosage of the rhizoma anemarrhenae is 18-22 parts by weight, the dosage of the moutan bark is 8-12 parts by weight, the dosage of the gardenia is 8-12 parts by weight, the dosage of the bupleurum is 8-12 parts by weight, the dosage of the white peony root is 28-32 parts by weight, the dosage of the atractylodes macrocephala is 28-32 parts by weight, the dosage of the poria cocos is 28-32 parts by weight, the dosage of the ginger is 8-12 parts by weight, the dosage of the mint is 8-12 parts by weight, the dosage of the cowherb seed is 28-32 parts by weight, the fructus liquidambaris is 13-18 parts by weight, and the, 28-32 parts of caulis spatholobi and 2-4 parts of liquorice.
Preferably, in each decocting process, the weight ratio of the total weight of the traditional Chinese medicine raw materials to the water is 1: 6-12; the decoction at least meets the following conditions: the decocting temperature is 100-;
preferably, the number of the decocting is 2-3, and the water extract is obtained by filtering the decoction through a 200-mesh screen.
Preferably, the preparation method further comprises: and mixing the water extract to obtain a traditional Chinese medicine extract, concentrating and drying.
Preferably, the process of concentrating comprises: concentrating the traditional Chinese medicine extracting solution I to obtain a concentrated solution with the density of 1.05-1.08g/mL at 60 ℃, centrifuging the concentrated solution to obtain a concentrated clear solution, and concentrating the concentrated clear solution II to obtain a thick paste with the density of 1.2-1.25g/mL at 60 ℃; the concentration I, the concentration II and the drying each independently satisfy the following conditions: the temperature is 60-70 deg.C, and the vacuum degree is 0.06-0.08 MPa.
In a third aspect, the present invention provides a Chinese medicinal preparation prepared by the above preparation method.
The fourth aspect of the invention provides a traditional Chinese medicine product for treating infertility, which contains the traditional Chinese medicine composition or the traditional Chinese medicine preparation prepared by the preparation method.
Through the technical scheme, the invention has the beneficial effects that:
1. the traditional Chinese medicine composition provided by the invention has scientific and excellent formula, the morinda officinalis has the effects of tonifying kidney yang and strengthening tendons and bones, the epimedium has the effects of tonifying kidney yang and strengthening tendons and bones, the curculigo orchioides has the effects of warming kidney yang and dispelling cold and dampness, and the three are monarch medicines which have the effects of warming and tonifying kidney yang, dispelling cold and removing dampness; the angelica and the caulis spatholobi can activate and enrich the blood, the radix paeoniae alba can nourish the blood and regulate menstruation, the three medicines are used together to make the blood generation active, the radix bupleuri can sooth the liver and relieve the depression, the ginger can warm the channels and stop bleeding, the cowherb seed can activate and dredge the channels, and the blood can be strengthened, and the six medicines are used as ministerial medicines to make the blood smoothly move; poria cocos is used for tonifying spleen and removing dampness, bighead atractylodes rhizome is used for tonifying spleen and qi, chinaroot greenbrier rhizome is used for removing dampness, spleen health is used for biochemical and active treatment, angelica, caulis spatholobi and white paeony root are used for generating blood, mint is used for assisting radix bupleuri in soothing liver, and phellodendron, cortex moutan, rhizoma anemarrhenae and gardenia kernel are used for clearing heat together, so that excessive yang is prevented from being warmed, deficiency heat of a body caused by yang deficiency is also produced, yin and yang are harmonized, and liquorice is used for harmonizing the other drugs, so that when the traditional Chinese medicine composition is combined, yin and yang are used for generating qi and blood, the operation is normal, the yin and yang are harmonized, the composition can be used for preparing pregnancy, has.
2. The preparation method of the traditional Chinese medicine preparation for treating infertility provided by the invention has the advantages of simple operation and easily obtained raw materials.
Detailed Description
The endpoints of the ranges and any values disclosed herein are not limited to the precise range or value, and such ranges or values should be understood to encompass values close to those ranges or values. For ranges of values, between the endpoints of each of the ranges and the individual points, and between the individual points may be combined with each other to give one or more new ranges of values, and these ranges of values should be considered as specifically disclosed herein.
In a first aspect, the invention provides a traditional Chinese medicine composition for treating infertility, which comprises the following components: rhizoma curculiginis, morinda officinalis, herba epimedii, angelica sinensis, phellodendron, rhizoma anemarrhenae, cortex moutan, gardenia, radix bupleuri, radix paeoniae alba, bighead atractylodes rhizome, poria cocos, ginger, mint, cowherb seed, fructus liquidambaris, chinaroot greenbrier, caulis spatholobi and liquorice.
In the invention, according to the addition and subtraction symptomatic therapy of the traditional Chinese medicines and the conditions of physique, symptoms and the like of a patient, the dosage of each traditional Chinese medicine component can be adjusted, and a proper numerical value is taken to achieve the optimal treatment effect.
The pharmacological analysis of the selected components of the invention is as follows:
the rhizoma Curculiginis is dried rhizome of Curculigo orchioides Gaertn. of Amaryllidaceae, has slightly fragrant smell, slightly bitter and pungent taste, and has effects of invigorating kidney, tonifying yang, replenishing essence and blood, strengthening tendons and bones, promoting blood circulation, and relieving swelling;
the radix Morindae officinalis is dried root of Morindae officinalis of Rubiaceae, and has no odor, sweet and slightly astringent taste, and can be used for treating sexual impotence, spermatorrhea, infertility due to cold womb, menoxenia, cold pain of lower abdomen, rheumatalgia, and tendons and bones flaccidity;
herba Epimedii is pungent, sweet and warm in taste, has effects of invigorating kidney yang, strengthening tendons and bones, and dispelling pathogenic wind and dampness, and can be used for treating sexual impotence, spermatorrhea, tendons and bones flaccidity, rheumatalgia, numbness and contracture, and climacteric hypertension;
radix Angelicae sinensis is the dried root of Angelica sinensis (Oliv.) Diels of Umbelliferae, has effects of replenishing blood, promoting blood circulation, regulating menstruation, relieving pain, and loosening bowel to relieve constipation, and is used for treating blood deficiency, sallow complexion, giddiness, cardiopalmus, menoxenia, amenorrhea, dysmenorrhea, cold deficiency, abdominal pain, rheumatalgia, traumatic injury, superficial infection, pyocutaneous disease, and constipation;
cortex Phellodendri is dried bark of Phellodendron chinensis Schneid of Rutaceae, has light smell, bitter taste, and stickiness after chewing, and has effects of clearing heat, eliminating dampness, clearing pathogenic fire, removing steam, removing toxic substance, and treating sore;
rhizoma anemarrhenae is bitter in taste and cold in nature, has effects of clearing heat-fire, nourishing yin and moistening dryness, and can be used for treating fever polydipsia, lung heat dry cough, bone steaming hectic fever, internal heat diabetes, intestinal dryness and constipation;
cortex moutan is dry root bark of Paeonia suffruticosa Andr.f. of Ranunculaceae, and has effects of clearing heat and cooling blood, promoting blood circulation and removing blood stasis, and relieving deficiency heat;
fructus Gardeniae is fruit of Gardenia jasminoides Ellis of Rubiaceae, has effects in protecting liver, promoting function of gallbladder, lowering blood pressure, tranquilizing mind, stopping bleeding, and relieving swelling, and can be used for treating icterohepatitis, sprain and contusion, hypertension, and diabetes;
bupleuri radix is dry root of Bupleurum scorzonerifolium or Bupleurum scorzonerifolium of Umbelliferae, has bitter and slightly cold nature, and enters liver and gallbladder channels, and has effects of harmonizing exterior and interior, dispersing stagnated liver qi and invigorating yang;
radix Paeoniae alba is dry root of Paeonia lactiflora pall of Ranunculaceae, and has bitter, sour and slightly cold properties, and has effects of nourishing blood, regulating menstruation, astringing yin, arresting sweating, softening liver, relieving pain, and suppressing liver yang;
the white atractylodes rhizome is bitter and sweet and warm, and has the effects of strengthening spleen and tonifying qi, eliminating dampness and promoting diuresis, suppressing sweating and preventing miscarriage;
poria is dried sclerotium of Wolf of Poria cocos (Schw.) of Polyporaceae, and has sweet, light and neutral taste, and has effects of promoting diuresis, eliminating dampness, invigorating spleen, and calming heart;
the ginger is fresh rhizome of a perennial herb ginger of the family Zingiberaceae, has pungent taste and slightly warm property, enters lung, spleen and stomach channels, and has the effects of relieving exterior syndrome, dispelling cold, warming middle-jiao, arresting vomiting, warming lung, relieving cough and detoxifying;
the mint is pungent in flavor and cool in nature, enters lung and liver meridians, and has the effects of dispelling wind and heat, clearing head and eyes, relieving sore throat and promoting eruption, and soothing liver and promoting qi circulation;
the dried mature seeds of Vaccaria segetalis (Neok.) Garcke of Caryophyllaceae have bitter taste and mild nature, and have effects of promoting blood circulation, dredging channels, promoting lactation, relieving swelling, inducing diuresis, and treating stranguria;
fructus Lipuidambaris is dry mature infructescence of Liquidambar Formosana Hance of Hamamelidaceae, and has bitter taste and mild property, and has effects of dispelling pathogenic wind, activating collaterals, promoting diuresis and dredging channels;
the rhizoma Smilacis chinensis is dried rhizome of Smilaz china L. of Liliaceae, is sweet, slightly bitter, astringent, and neutral, and has effects of removing dampness, eliminating turbid pathogen, dispelling pathogenic wind, removing arthralgia, removing toxic substance, and removing blood stasis;
caulis Spatholobi is dried stem of Spatholobus suberectus Dunn of Leguminosae, is bitter and sweet in taste and warm in nature, and has effects of promoting blood circulation, replenishing blood, regulating menstruation, relieving pain, relieving rigidity of muscles and activating collaterals;
the liquorice is sweet in taste and neutral in nature, and has the effects of tonifying spleen and qi, clearing away heat and toxic materials, eliminating phlegm and stopping cough, relieving spasm and pain and harmonizing the drugs.
Preferably, relative to 10 parts by weight of the rhizoma curculiginis, the content of the morinda officinalis is 5-15 parts by weight, the content of the epimedium is 5-15 parts by weight, the content of the angelica sinensis is 15-25 parts by weight, the content of the phellodendron bark is 5-15 parts by weight, the content of the rhizoma anemarrhenae is 15-25 parts by weight, the content of the moutan bark is 5-15 parts by weight, the content of the gardenia is 5-15 parts by weight, the content of the bupleurum root is 5-15 parts by weight, the content of the white peony root is 25-35 parts by weight, the content of the bighead atractylodes rhizome is 25-35 parts by weight, the content of the poria cocos is 25-35 parts by weight, the content of the ginger is 5-15 parts by weight, the content of the mint is 5-15 parts by weight, the content of the cowherb seed is 25-35 parts by weight, the sweetgum fruit is 10-20 parts by weight, 25-35 parts of caulis spatholobi and 1-5 parts of liquorice.
More preferably, relative to 10 parts by weight of the rhizoma curculiginis, the content of the morinda officinalis is 8-12 parts by weight, the content of the epimedium is 8-12 parts by weight, the content of the angelica sinensis is 18-22 parts by weight, the content of the phellodendron bark is 8-12 parts by weight, the content of the rhizoma anemarrhenae is 18-22 parts by weight, the content of the moutan bark is 8-12 parts by weight, the content of the gardenia is 8-12 parts by weight, the content of the bupleurum root is 8-12 parts by weight, the content of the white peony root is 28-32 parts by weight, the content of the white atractylodes rhizome is 28-32 parts by weight, the content of the poria cocos is 28-32 parts by weight, the content of the ginger is 8-12 parts by weight, the content of the mint is 8-12 parts by weight, the content of the cowherb seed is 28-32 parts by weight, the sweetgum fruit is 13-18 parts by weight, the content, 28-32 parts of caulis spatholobi and 2-4 parts of liquorice.
In a second aspect, the present invention provides a method for preparing a Chinese medicinal preparation for treating infertility, the method comprising the steps of: mixing rhizoma curculiginis, morinda officinalis, epimedium herb, angelica, phellodendron, rhizoma anemarrhenae, moutan bark, gardenia, radix bupleuri, radix paeoniae alba, bighead atractylodes rhizome, poria cocos, ginger, mint, cowherb seed, fructus liquidambaris, chinaroot greenbrier, caulis spatholobi and liquorice with water, decocting for multiple times, and mixing water extract obtained by each decocting to obtain the traditional Chinese medicine preparation for treating infertility.
Preferably, relative to 10 parts by weight of the rhizoma curculiginis, the dosage of the morinda officinalis is 5-15 parts by weight, the dosage of the epimedium is 5-15 parts by weight, the dosage of the angelica is 15-25 parts by weight, the dosage of the phellodendron is 5-15 parts by weight, the dosage of the rhizoma anemarrhenae is 15-25 parts by weight, the dosage of the moutan bark is 5-15 parts by weight, the dosage of the gardenia is 5-15 parts by weight, the dosage of the bupleurum is 5-15 parts by weight, the dosage of the white peony root is 25-35 parts by weight, the dosage of the atractylodes macrocephala is 25-35 parts by weight, the dosage of the poria cocos is 25-35 parts by weight, the dosage of the ginger is 5-15 parts by weight, the dosage of the mint is 5-15 parts by weight, the dosage of the cowherb seed is 25-35 parts by weight, the sweetgum fruit is 10-20 parts by weight, the dosage of, 25-35 parts of caulis spatholobi and 1-5 parts of liquorice.
More preferably, relative to 10 parts by weight of the rhizoma curculiginis, the dosage of the morinda officinalis is 8-12 parts by weight, the dosage of the epimedium is 8-12 parts by weight, the dosage of the angelica is 18-22 parts by weight, the dosage of the phellodendron is 8-12 parts by weight, the dosage of the rhizoma anemarrhenae is 18-22 parts by weight, the dosage of the moutan bark is 8-12 parts by weight, the dosage of the gardenia is 8-12 parts by weight, the dosage of the bupleurum is 8-12 parts by weight, the dosage of the white peony root is 28-32 parts by weight, the dosage of the atractylodes macrocephala is 28-32 parts by weight, the dosage of the poria cocos is 28-32 parts by weight, the dosage of the ginger is 8-12 parts by weight, the dosage of the mint is 8-12 parts by weight, the dosage of the cowherb is 28-32 parts by weight, the sweetgum fruit is 13-18 parts by weight, and the dosage of the, 28-32 parts of caulis spatholobi and 2-4 parts of liquorice.
The conditions of the decoction process are not particularly limited, and the effective ingredients in the Chinese medicinal materials can be extracted by decoction, and generally, the decoction conditions include temperature, time, the times of decoction, the mass ratio of the amount of the Chinese medicinal materials to water in each decoction process, and the like. Preferably, in each decocting process, the weight ratio of the total weight of the traditional Chinese medicine raw materials to the water is 1: 6-12; the decoction at least meets the following conditions: the decocting temperature is 100-; the decocting time is 0.5-2h, specifically 0.5h, 1h, 1.5h, 2h, or any value between the two values; the number of times of decoction is 2-3. The inventor finds that under the preferred embodiment, the extraction efficiency and yield of the effective active ingredients in the traditional Chinese medicine raw materials are improved.
According to the present invention, the water extract may be separated from the material liquid obtained by each decoction by filtration, centrifugation or standing sedimentation, and preferably, the water extract is obtained by filtering the material liquid obtained by the decoction through a 200-mesh screen.
According to the invention, the water extract obtained by each decoction can be directly used for treatment after being mixed, or can be used for treatment after being further processed into other forms of traditional Chinese medicine preparations or traditional Chinese medicine products. Preferably, the preparation method further comprises the following steps: and mixing the water extract to obtain a traditional Chinese medicine extract, concentrating and drying. The inventors have found that, in this preferred embodiment, it is advantageous for use by the patient.
In the present invention, the concentration and drying processes and equipment are not particularly limited, for example, the concentration may be performed in a concentration tank or any other concentration manner, and the drying may be performed by hot air drying, vacuum drying or any other drying manner. Preferably, the concentration process comprises: concentrating the traditional Chinese medicine extracting solution I to obtain a concentrated solution with the density of 1.05-1.08g/mL at 60 ℃, centrifuging the concentrated solution to obtain a concentrated clear solution, and concentrating the concentrated clear solution II to obtain a thick paste with the density of 1.2-1.25g/mL at 60 ℃; the concentration I, the concentration II and the drying each independently satisfy the following conditions: the temperature is 60-70 deg.C, specifically 60 deg.C, 62 deg.C, 64 deg.C, 66 deg.C, 68 deg.C, 70 deg.C, or any value between the above two values; the vacuum degree is 0.06-0.08 MPa, specifically 0.06MPa, 0.07MPa, 0.08MPa, or any value between the above two values. The inventors have found that in this preferred embodiment it is advantageous to increase the efficiency of concentration I, concentration II and drying.
In a third aspect, the invention provides a Chinese medicinal preparation prepared by the preparation method.
In a fourth aspect, the invention provides a traditional Chinese medicine product for treating infertility, which contains the traditional Chinese medicine composition or the traditional Chinese medicine preparation prepared by the preparation method. Preferably, when the traditional Chinese medicine product contains the traditional Chinese medicine composition, the content of active ingredients is 20-50 wt%; when the traditional Chinese medicine preparation prepared by the preparation method is contained, the content of active ingredients is 2-10 wt%.
According to the invention, the dosage form of the traditional Chinese medicine product can be decocted extract, decocted agent, mixture, oral liquid, granules, pills or tablets, and the traditional Chinese medicine product is prepared by adding conventional auxiliary materials into the traditional Chinese medicine composition or the traditional Chinese medicine preparation to prepare the corresponding decocted extract, decocted agent, mixture, oral liquid, granules, pills or tablets. Exemplarily, the water extract is mixed to obtain a traditional Chinese medicine extract, the traditional Chinese medicine extract is concentrated and dried to obtain dry paste, the dry paste is crushed to obtain dry paste powder, the dry paste powder is mixed with steviosin and dextrin, 90% ethanol is added to prepare soft materials, particles which can pass through a 14-mesh screen are prepared, and then the particles are dried and granulated to obtain the traditional Chinese medicine product.
The present invention will be described in detail below by way of examples.
In the following examples, curculigo orchioides, morinda officinalis, epimedium herb, angelica, phellodendron, rhizoma anemarrhenae, moutan bark, gardenia, radix bupleuri, radix paeoniae alba, rhizoma atractylodis macrocephalae, poria cocos, ginger, mint, cowherb seed, fructus liquidambaris, smilax, caulis spatholobi and liquorice are conventional products which are commercially available.
The preparation process of the embodiment comprises the following steps:
(1) weighing rhizoma Curculiginis, radix Morindae officinalis, herba Epimedii, radix Angelicae sinensis, cortex Phellodendri, rhizoma anemarrhenae, cortex moutan, fructus Gardeniae, bupleuri radix, radix Paeoniae alba, Atractylodis rhizoma, Poria, rhizoma Zingiberis recens, herba Menthae, semen Vaccariae, fructus Lipuidambaris, rhizoma Smilacis chinensis, caulis Spatholobi, and Glycyrrhrizae radix;
(2) mixing the raw materials weighed in the step (1) with water, decocting for multiple times, filtering feed liquid obtained by each decocting through a 200-mesh screen to obtain water extract, and mixing the water extracts obtained by multiple times of decocting to obtain traditional Chinese medicine extract;
(3) concentrating the traditional Chinese medicine extracting solution obtained in the step (2) to obtain a concentrated solution by a concentration I, centrifuging the concentrated solution to obtain a concentrated clear solution, concentrating the concentrated clear solution by a concentration II to obtain a thick paste, and drying the thick paste to obtain the traditional Chinese medicine preparation;
(4) crushing the Chinese medicinal preparation obtained in the step (3) to obtain dry paste powder, mixing the dry paste powder with dextrin, steviosin and 90 vol% ethanol in a mass ratio of 1: 1: 0.5: 0.35 mixing, granulating, sieving with 14 mesh sieve, drying to control water content of granule within 6%, and grading to obtain Chinese medicinal preparation.
The specific dosage of each Chinese medicinal material of examples 1-5 is shown in Table 1, and the specific condition parameters in the preparation process of examples 1-5 are shown in Table 2.
Table 1 amounts of each raw material used in examples 1 to 5
| Example 1 | Example 2 | Example 3 | Example 4 | Example 5 | |
| Rhizoma Curculiginis | 10g | 10g | 10g | 10g | 10g |
| Morinda officinalis | 10g | 12g | 8g | 15g | 5g |
| Herba Epimedii | 10g | 12g | 8g | 15g | 5g |
| Radix Angelicae sinensis | 20g | 22g | 18g | 25g | 15g |
| Huang Bai | 10g | 12g | 8g | 15g | 5g |
| Rhizoma anemarrhenae | 20g | 22g | 18g | 25g | 15g |
| Cortex moutan | 10g | 12g | 8g | 15g | 5g |
| Gardenia jasminoides ellis | 10g | 12g | 8g | 15g | 5g |
| Radix bupleuri | 10g | 12g | 8g | 15g | 5g |
| White peony root | 30g | 32g | 28g | 35g | 25g |
| White atractylodes rhizome | 30g | 32g | 28g | 35g | 25g |
| Poria cocos (Schw.) wolf | 30g | 32g | 28g | 35g | 25g |
| Ginger (fresh ginger) | 10g | 12g | 8g | 15g | 5g |
| Mint | 10g | 12g | 8g | 15g | 5g |
| Seed of cowherb | 30g | 32g | 28g | 35g | 25g |
| Road-shaped passageway | 15g | 18g | 13g | 20g | 10g |
| Smilax china | 30g | 32g | 28g | 35g | 25g |
| Caulis Spatholobi | 30g | 32g | 28g | 35g | 25g |
| Licorice root, radix Glycyrrhizae | 3g | 4g | 2g | 5g | 1g |
Table 2 condition parameters in the preparation process of examples 1 to 5
Test example
The therapeutic effects of the Chinese medicinal preparations prepared in examples 1 to 5 were measured.
The patients with infertility were selected and randomly divided into 5 groups of 30 patients, and the patients in each group had no obvious difference in age, disease course and other basic data (P > 0.05), and were comparable.
The patient takes the traditional Chinese medicine composition for treating infertility every day, the dose is 10g, and the traditional Chinese medicine composition is taken in the morning and at night for 3-6 months continuously. The clinical treatment effect of the patients is observed and recorded, the test indexes are cycle ovulation rate and pregnancy rate, and the specific test results are shown in table 3.
TABLE 3 measurement results of therapeutic effects of the Chinese medicinal preparations prepared in examples 1 to 5
| Ovulation rate (%) | Pregnancy Rate (%) | |
| Example 1 | 85.5 | 75 |
| Example 2 | 82.7 | 72.4 |
| Example 3 | 81.3 | 69.8 |
| Example 4 | 75.6 | 64.8 |
| Example 5 | 73.5 | 65.1 |
Clinical data
The curative effect of the Chinese medicinal composition is illustrated by clinical data as follows:
case one: zhang Ying, female, age 36, premature abortion caused by many times of abortion, confirmed habitual abortion diagnosis, many treatment, no effect, self-administration of the Chinese medicinal composition provided by the embodiment 1 of the invention, each dose of the Chinese medicinal composition is 10g, the Chinese medicinal composition is taken once in the morning and at night, the feeling is obviously recovered after one month, two months of pregnancy is continued, no abortion is caused, and a healthy girl is bred.
Case two: the Chinese medicinal composition has the advantages that certain forest and women age 32 years old suffer from irregular menstruation, have unstable menstrual cycle, are not pregnant for 5 years at marriage, also suffer from polycystic ovarian syndrome after examination, have many medical treatment and have unsatisfactory effect; then, the traditional Chinese medicine composition provided by the embodiment 1 of the invention is taken by oneself, the dosage is 10g each time, the medicine is taken once in the morning and evening, the menstrual cycle is normal after three months, and after the medicine is taken for one month continuously, no relapse occurs and the disease is basically cured; about half a year later, the child is pregnant.
Case three: the traditional Chinese medicine composition provided by the embodiment 1 of the invention has the dosage of 10g each time, is taken once in the morning and at night, relieves the illness after two months, and finds that the patient is pregnant after continuing to take the composition for one month.
The preferred embodiments of the present invention have been described above in detail, but the present invention is not limited thereto. Within the scope of the technical idea of the invention, many simple modifications can be made to the technical solution of the invention, including combinations of various technical features in any other suitable way, and these simple modifications and combinations should also be regarded as the disclosure of the invention, and all fall within the scope of the invention.
Claims (10)
1. A traditional Chinese medicine composition for treating infertility is characterized by comprising the following components: rhizoma curculiginis, morinda officinalis, herba epimedii, angelica sinensis, phellodendron, rhizoma anemarrhenae, cortex moutan, gardenia, radix bupleuri, radix paeoniae alba, bighead atractylodes rhizome, poria cocos, ginger, mint, cowherb seed, fructus liquidambaris, chinaroot greenbrier, caulis spatholobi and liquorice.
2. The traditional Chinese medicine composition of claim 1, wherein, relative to 10 parts by weight of the curculigo orchioides, the content of morinda officinalis is 5-15 parts by weight, the content of epimedium is 5-15 parts by weight, the content of angelica is 15-25 parts by weight, the content of phellodendron is 5-15 parts by weight, the content of anemarrhena is 15-25 parts by weight, the content of moutan bark is 5-15 parts by weight, the content of gardenia is 5-15 parts by weight, the content of bupleurum is 5-15 parts by weight, the content of white peony root is 25-35 parts by weight, the content of atractylodes macrocephala is 25-35 parts by weight, the content of poria cocos is 25-35 parts by weight, the content of ginger is 5-15 parts by weight, the content of mint is 5-15 parts by weight, the content of vaccaria segetalis is 25-35 parts by weight, the content of sweetgum fruit is 10-20 parts by, the content of the smilax china is 25 to 35 weight portions, the content of the suberect spatholobus stem is 25 to 35 weight portions, and the content of the liquorice is 1 to 5 weight portions.
3. The traditional Chinese medicine composition of claim 2, wherein, relative to 10 parts by weight of the curculigo orchioides, the content of morinda officinalis is 8-12 parts by weight, the content of epimedium is 8-12 parts by weight, the content of angelica sinensis is 18-22 parts by weight, the content of phellodendron bark is 8-12 parts by weight, the content of anemarrhena asphodeloides is 18-22 parts by weight, the content of moutan bark is 8-12 parts by weight, the content of gardenia jasminoides ellis is 8-12 parts by weight, the content of bupleurum chinense is 8-12 parts by weight, the content of white peony root is 28-32 parts by weight, the content of atractylodes macrocephala is 28-32 parts by weight, the content of poria cocos is 28-32 parts by weight, the content of ginger is 8-12 parts by weight, the content of mint is 8-12 parts by weight, the content of vaccaria segetalis seed is 28-32 parts by, the content of the smilax china is 28 to 32 weight portions, the content of the suberect spatholobus stem is 28 to 32 weight portions, and the content of the liquorice is 2 to 4 weight portions.
4. A preparation method of a traditional Chinese medicine preparation for treating infertility is characterized by comprising the following steps: mixing rhizoma curculiginis, morinda officinalis, epimedium herb, angelica, phellodendron, rhizoma anemarrhenae, moutan bark, gardenia, radix bupleuri, radix paeoniae alba, bighead atractylodes rhizome, poria cocos, ginger, mint, cowherb seed, fructus liquidambaris, chinaroot greenbrier, caulis spatholobi and liquorice with water, decocting for multiple times, and mixing water extract obtained by each decocting to obtain the traditional Chinese medicine preparation for treating infertility.
5. The method of claim 4, wherein the Morinda officinalis is 5-15 parts by weight, the Epimedium is 5-15 parts by weight, the Angelica sinensis is 15-25 parts by weight, the Phellodendri cortex is 5-15 parts by weight, the anemarrhenae rhizoma is 15-25 parts by weight, the moutan cortex is 5-15 parts by weight, the Gardeniae fructus is 5-15 parts by weight, the bupleuri radix is 5-15 parts by weight, the Paeoniae radix is 25-35 parts by weight, the Atractylodes rhizome is 25-35 parts by weight, the Poria cocos is 25-35 parts by weight, the Zingiberis rhizoma crudus is 5-15 parts by weight, the Menthae herba is 5-15 parts by weight, the Vaccaria segetalis is 25-35 parts by weight, and the Liquidambar formosana hance is 10-20 parts by weight, the dosage of the smilax china is 25 to 35 weight portions, the dosage of the suberect spatholobus stem is 25 to 35 weight portions, and the dosage of the liquorice is 1 to 5 weight portions;
preferably, relative to 10 parts by weight of the rhizoma curculiginis, the dosage of the morinda officinalis is 8-12 parts by weight, the dosage of the epimedium is 8-12 parts by weight, the dosage of the angelica is 18-22 parts by weight, the dosage of the phellodendron is 8-12 parts by weight, the dosage of the rhizoma anemarrhenae is 18-22 parts by weight, the dosage of the moutan bark is 8-12 parts by weight, the dosage of the gardenia is 8-12 parts by weight, the dosage of the bupleurum is 8-12 parts by weight, the dosage of the white peony root is 28-32 parts by weight, the dosage of the atractylodes macrocephala is 28-32 parts by weight, the dosage of the poria cocos is 28-32 parts by weight, the dosage of the ginger is 8-12 parts by weight, the dosage of the mint is 8-12 parts by weight, the dosage of the cowherb seed is 28-32 parts by weight, the fructus liquidambaris is 13-18 parts by weight, and the, 28-32 parts of caulis spatholobi and 2-4 parts of liquorice.
6. The preparation method according to claim 4, wherein the weight ratio of the total weight of the Chinese medicinal materials to water in each decocting process is 1: 6-12; the decoction at least meets the following conditions: the decocting temperature is 100-;
preferably, the number of the decocting is 2-3, and the water extract is obtained by filtering the decoction through a 200-mesh screen.
7. The production method according to any one of claims 4 to 6, characterized by further comprising: and mixing the water extract to obtain a traditional Chinese medicine extract, concentrating and drying.
8. The method of claim 7, wherein the concentrating comprises: concentrating the traditional Chinese medicine extracting solution I to obtain a concentrated solution with the density of 1.05-1.08g/mL at 60 ℃, centrifuging the concentrated solution to obtain a concentrated clear solution, and concentrating the concentrated clear solution II to obtain a thick paste with the density of 1.2-1.25g/mL at 60 ℃;
the concentration I, the concentration II and the drying each independently satisfy the following conditions: the temperature is 60-70 deg.C, and the vacuum degree is 0.06-0.08 MPa.
9. The preparation method according to any one of claims 4 to 8.
10. A traditional Chinese medicine product for treating infertility, which is characterized in that the traditional Chinese medicine product contains the traditional Chinese medicine composition of any one of claims 1 to 3 or the traditional Chinese medicine preparation prepared by the preparation method of any one of claims 4 to 8.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110025885.0A CN112587645A (en) | 2021-01-08 | 2021-01-08 | Traditional Chinese medicine composition for treating infertility, traditional Chinese medicine preparation and traditional Chinese medicine product |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110025885.0A CN112587645A (en) | 2021-01-08 | 2021-01-08 | Traditional Chinese medicine composition for treating infertility, traditional Chinese medicine preparation and traditional Chinese medicine product |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112587645A true CN112587645A (en) | 2021-04-02 |
Family
ID=75207284
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110025885.0A Pending CN112587645A (en) | 2021-01-08 | 2021-01-08 | Traditional Chinese medicine composition for treating infertility, traditional Chinese medicine preparation and traditional Chinese medicine product |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112587645A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023005130A1 (en) * | 2021-07-26 | 2023-02-02 | 安徽医科大学 | Traditional chinese medicine composition for treating infertility, and preparation method therefor and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1306853A (en) * | 2000-01-24 | 2001-08-08 | 彭少芳 | Pregnancy promoting medicine for treating hyperprolactinemia sterility and its preparation |
| CN103251854A (en) * | 2013-05-31 | 2013-08-21 | 孙彰 | Traditional Chinese medicine composition for treating female sterility |
| CN104258191A (en) * | 2013-05-31 | 2015-01-07 | 王雪松 | Preparation method of traditional Chinese medicine composition for treating sterility of women |
-
2021
- 2021-01-08 CN CN202110025885.0A patent/CN112587645A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1306853A (en) * | 2000-01-24 | 2001-08-08 | 彭少芳 | Pregnancy promoting medicine for treating hyperprolactinemia sterility and its preparation |
| CN103251854A (en) * | 2013-05-31 | 2013-08-21 | 孙彰 | Traditional Chinese medicine composition for treating female sterility |
| CN104258191A (en) * | 2013-05-31 | 2015-01-07 | 王雪松 | Preparation method of traditional Chinese medicine composition for treating sterility of women |
Non-Patent Citations (4)
| Title |
|---|
| 严英等: "输卵管介入再通术联合中医综合疗法治疗输卵管阻塞性不孕症的临床研究", 《新中医》 * |
| 李俊等: "《当代有效合方的临床应用》", 30 September 2002, 军事医学科学出版社 * |
| 毕蓉蓉: "中医药治疗不孕症138例疗效观察", 《上海中医药杂志》 * |
| 狄俊英等: "补肾调冲药对去卵巢小鼠作用的实验研究", 《天津中医学院学报》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023005130A1 (en) * | 2021-07-26 | 2023-02-02 | 安徽医科大学 | Traditional chinese medicine composition for treating infertility, and preparation method therefor and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107789484B (en) | Traditional Chinese medicine composition for treating irregular menstruation and preparation method thereof | |
| CN115252740B (en) | Traditional Chinese medicine composition for conditioning irregular menstruation and preparation method thereof | |
| CN104984297A (en) | Application of pharmaceutical composition in preparation of drugs for treating amenorrhea | |
| CN101940733B (en) | Traditional Chinese medicinal composition for curing nephritis diseases and preparation method thereof | |
| CN104922613A (en) | Medicine composite for treating sterility and preparation method thereof | |
| CN106511781A (en) | Water-paste pills | |
| CN104225166A (en) | Chinese medicine composition for treating amenorrhea and preparation method thereof | |
| CN101972448B (en) | Chinese medicinal composition for treating liver cancer | |
| CN112587645A (en) | Traditional Chinese medicine composition for treating infertility, traditional Chinese medicine preparation and traditional Chinese medicine product | |
| CN107320631B (en) | Anti-fatigue traditional Chinese medicine composition and preparation method thereof | |
| CN105169271A (en) | Application of medicine composite in preparation of medicine for treating amenorrhea | |
| CN104984296A (en) | Pharmaceutical composition for treating female climacteric syndrome and preparation method thereof | |
| CN109876127B (en) | Blood-nourishing angelica sinensis capsule and preparation method thereof | |
| CN105169338A (en) | Medicine composition for treating female climacteric syndromes and preparation method thereof | |
| CN105213511A (en) | A kind of pharmaceutical composition is for the preparation of the purposes in treatment amenorrhea medicine | |
| CN105288538A (en) | Application of medicine composition for preparing medicine for treating amenorrhea | |
| CN104840891A (en) | Traditional Chinese medicine preparation used for treating alcoholic cardiomyopathy and preparation method thereof | |
| CN110638937A (en) | Traditional Chinese medicine for treating insomnia | |
| CN111166825A (en) | Medicine for treating early hypertension yin deficiency stroke hemiplegia and preparation method thereof | |
| CN104027473A (en) | Pill for treating dysmenorrheal and preparation method of pill | |
| CN114712470B (en) | Medicine for treating deficiency of kidney of men and preparation method thereof | |
| CN104162090B (en) | Pharmaceutical composition and preparation method thereof | |
| CN103656199B (en) | A kind of Chinese medicine for the treatment of deficiency of kidney yin syndrome cough | |
| CN114796372B (en) | A Chinese medicinal watered pill for treating vitiligo, and its preparation method | |
| CN108524731B (en) | Traditional Chinese medicine composition for treating myasthenia gravis and preparation thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |