CN104027473A - Pill for treating dysmenorrheal and preparation method of pill - Google Patents
Pill for treating dysmenorrheal and preparation method of pill Download PDFInfo
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- CN104027473A CN104027473A CN201410292886.1A CN201410292886A CN104027473A CN 104027473 A CN104027473 A CN 104027473A CN 201410292886 A CN201410292886 A CN 201410292886A CN 104027473 A CN104027473 A CN 104027473A
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Abstract
The invention discloses a pill for treating dysmenorrheal. The pill is prepared from the following materials in parts by weight: 7-11 parts of Chinese angelica, 8-14 parts of prepared rehmannia root, 4-8 parts of ligusticum wallichii, 8-12 parts of white paeony roots, 4-6 parts of peanuts, 2-4 parts of red dates, 3-5 parts of red beans, 1-3 parts of medlar and 5-7 parts of brown sugar. The invention further provides a preparation method of the pill for treating dysmenorrheal. The pill for treating dysmenorrheal disclosed by the invention can effectively treat dysmenorrheal caused by blood supply obstruction and deficiency of blood of the female, is small in toxic and side effect; a preparation method of the pill is simple.
Description
Technical field
The present invention relates to the technical field of pill, particularly relate to a kind of dysmenorrhea pill and preparation method thereof for the treatment of.
Background technology
The common disease of a kind of gynecological during dysmenorrhea, is divided into two kinds of constitutional and Secondary cases clinically, the traditional Chinese medical science think the blood fortune that caused by many reasons need not, consequently " stagnation of QI and blood may bring about pain " or punching appoint a uterus to lose in moistening to support not flourish and pain.Work and life that dysmenorrhea is women bring many difficulties, although there is on the market the medicine of multiple relieving dysmenorrhea, as indometacin, ibuprofen, atropine, also have and adopt take traditional Chinese medicine soup, JIAWEI XIAOYAOWAN, acupuncture etc., but these medicines and acupuncture etc. generally can only be alleviated and be palliated the agonizing sufferings, can not fundamentally remove sufferer, and Western medicine is large to the side effect of human body; Chinese medicinal decoction is long the course for the treatment of, and effect is slow, decocts trouble; Acupuncture can only temporaryly be alleviated, and can not eradicate dysmenorrhea, and the course for the treatment of is long.Therefore the development of novel drugs is imperative.
Prescription about treatment dysmenorrhea has a lot of relevant reports, the disclosed a kind of medicine for the treatment of dysmenorrhea of the medicine of the disclosed treatment dysmenorrhea of Chinese invention patent CN102210846B and CN101361959B for example, all to be combined by multi-medicament, and by traditional method decoction, traditional decoction method trouble, effective ingredient is easily destroyed, can not make full use of the effective ingredient of medicine, waste raw material, and therapeutic effect is not obvious.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of women that can effectively treat because of the dysmenorrhea that blood fortune is obstructed, blood deficiency causes, the treatment dysmenorrhea pill that toxic and side effects is little.
For achieving the above object, the present invention takes following technical scheme:
Treat a dysmenorrhea pill, by following weight portion raw material, made: 7～11 parts of Radix Angelicae Sinensis, 8～14 parts, Radix Rehmanniae Preparata, 4～8 parts of Rhizoma Chuanxiongs, 8～12 parts of the Radix Paeoniae Albas, 4～6 parts of Semen arachidis hypogaeaes, 2～4 parts of Fructus Jujubaes, 3～5 parts, Semen Phaseoli, 1～3 part of Fructus Lycii, 5～7 parts, brown sugar.
Best, a kind of dysmenorrhea pill for the treatment of, is made by following weight portion raw material: Radix Angelicae Sinensis 9,12 parts, Radix Rehmanniae Preparata, 6 parts of Rhizoma Chuanxiongs, 10 parts of the Radix Paeoniae Albas, 5 parts of Semen arachidis hypogaeaes, 3 parts of Fructus Jujubaes, 4 parts, Semen Phaseoli, 2 parts of Fructus Lyciis, 6 parts, brown sugar.
The present invention also provides a kind of preparation method for the treatment of dysmenorrhea pill, and preparation process is as follows:
(1) take raw material, and whole raw material powders are broken into 150～300 order fine powders;
(2) add 7～10 times of water of raw material gross weight, regulate pH value to 4.0～5.5, add pectase, the cellulase of raw material gross weight 1%～3% to carry out enzymolysis 12～24 hours, put into enzymatic vessel, controlling temperature is 45～65 ℃, and the weight ratio of pectase, cellulase is 3:1;
(3) enzymolysis medicine slurry step (2) being obtained carries out air-distillation;
(4) filter, concentrated, with water pill, dry, make treatment dysmenorrhea pill.
Preferably, the described air-distillation of step (2) is carried out three times continuously, and the vapo(u)rizing temperature of three times is respectively 85～90 ℃, and 92～95 ℃, 97～100 ℃, the time of each distillation is 30～40min.
In treatment TONGJING WAN raw material:
Radix Angelicae Sinensis is the root of samphire Radix Levistici Officinalis.Nature and flavor: sweet in the mouth; Pungent; Bitter; Warm in nature.Function cures mainly: enrich blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation.Cure mainly all cards of blood deficiency; Menoxenia; Amenorrhea; Dysmenorrhea; Lump in the abdomen knot is poly-; Metrorrhagia; Asthenia cold abdominalgia; Flaccidity syndrome and arthralgia syndrome; Numbness of the skin; Dryness of the intestine dyschezia; Heavy after bloody dysentery; Ulcer sores; Injury from falling down.
Radix Rehmanniae Preparata is scrophulariaceae rehmannia glutinosa plant (formal name used at school: tuber Rehmannia glutinosa).Nature and flavor: sweet in the mouth; Warm in nature.Function cures mainly: enrich blood moist; Benefit essence is filled out marrow.Cure mainly blood tiger sallow; Dizzy cardiopalmus; Menoxenia; Collapse more than; Hepatic and renal YIN deficiency; Hectic fever night sweat; Seminal emission sexual impotence; Infertility; Soreness of the waist and knees; Hiccough and deaf; The head is dim-sighted; Early whitening of beard and hair; Quench one's thirst; Constipation; The dyspnea with rapid and short breath of suffering from a deficiency of the kidney.
Rhizoma Chuanxiong is the dry rhizome of samphire Rhizoma Chuanxiong (Ligusticum chuanxiong).Nature and flavor: blood circulation promoting and blood stasis dispelling; Activating QI to alleviate the depression; Wind-expelling pain-stopping.Function cures mainly: blood circulation promoting and blood stasis dispelling; Activating QI to alleviate the depression; Wind-expelling pain-stopping.Medicine first choice for the treatment of headache.Menoxenia; Amenorrhea dysmenorrhea; The stagnant raw meat pain of the stasis of blood in puerperal; Lump in the abdomen lump; Pain in chest and hypochondrium; Have a headache dizzy; Anemofrigid-damp arthralgia; Traumatic injury; Ulcer sores.
The Radix Paeoniae Alba is the root of dicotyledon medicine ranunculaceae plant Radix Paeoniae (cultigen).Nature and flavor: cool in nature, bitter in the mouth acid, is slightly cold.Function cures mainly: the easing the affected liver of enriching blood, suppressing the hyperactive liver pain relieving, yin fluid astringing are received antiperspirant.Be applicable to fever due to yin deficiency, menoxenia, the breast abdomen pain over the hypochondriac region, extremity contraction anxious, dysentery stomachache, spontaneous sweating, metrorrhagia, be with inferior disease.
Semen arachidis hypogaeae is the seed of leguminous plant Semen arachidis hypogaeae.Nature and flavor: sweet, flat, nontoxic.Function cures mainly: the appetizing of being amusing, treating blood disorders lactogenesis, lung moistening diuretic.Harness the river swollen, breast closes, hematuria; Folium Arachidis hypogaeae can be controlled insomnia, the Pericarppium arachidis hypogaeae effect of reducing blood pressure, and Testa arachidis hypogaeae is to the multiple hemorrhage good curative effect that all has.
Fructus Jujubae is the fruit of Rhamnaceae plant Fructus Jujubae Ziziphus jujuba.Nature and flavor: tepor, sweet.Function: invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.
Semen Phaseoli is the plant seeds such as Ormosia hosiei, Semen adenantherae pavoninae and Semen Abri Precatorii.Nature and flavor: property is flat, sweet in the mouth acid.Function cures mainly: the diuretic kind that disappears, removing toxic substances and promoting pus discharge.For edema distension, beriberi edema, jaundice dark coloured urine, rheumatism pyretic arthralgia, carbuncle sore tumefacting virus, abdominalgia with intestinal abscess.Fructus Lycii,
Brown sugar, for the stem of gramineous herbaceous plant Caulis Sacchari sinensis refines through squeezing extracting juice the redness of the skin or complexion crystalline solid forming.Sweet in the mouth, warm in nature.Performance: energy invigorating middle warmer emergency, and the blood stasis of blood.
Compared with prior art, tool of the present invention has the following advantages:
1, the present invention processes the compound enzyme of raw material, can fully decompose the composition in raw material, makes macromolecular substances fragment into micromolecule composition, makes material composition be easier to a times absorption of human body.
2, the present invention adopts the mode of air-distillation to extract the effective ingredient in raw material to raw material, compare the mode of traditional decoction, air-distillation process is gentle, in still-process, adopt the distillating method of the segmentation temperature difference and carry out continuously three air-distillations, can extract to large extent the composition in raw material, making full use of raw material resources, improve drug effect, reduce costs.
3, the Chinese medicine that has blood circulation promoting and enriching in raw material of the present invention, the raw material combination of two types, can efficiently treat women because blood fortune is obstructed, blood deficiency causes dysmenorrhea.
4, this medicine does not add food additive, green safety, and toxic and side effects is little.
The specific embodiment
Below in conjunction with embodiment, the invention will be further described, but the present invention is not limited to these embodiment.
Embodiment 1
(1) by following weight portion, take raw material: 7 parts of Radix Angelicae Sinensis, 8 parts, Radix Rehmanniae Preparata, 8 parts of Rhizoma Chuanxiongs, 12 parts of the Radix Paeoniae Albas, 6 parts of Semen arachidis hypogaeaes, 2 parts of Fructus Jujubaes, 5 parts, Semen Phaseoli, 1 part of Fructus Lycii, 5 parts, brown sugar;
(2) whole raw material powders are broken into 150 order fine powders;
(3) add 7 times of water of raw material gross weight, regulate pH value to 4.0, add pectase, the cellulase of raw material gross weight 1% to carry out enzymolysis 12 hours, put into enzymatic vessel, controlling temperature is 45 ℃, and the weight ratio of pectase, cellulase is 3:4;
(4) enzymolysis medicine slurry step (2) being obtained carries out three air-distillations continuously, and the vapo(u)rizing temperature of three times is respectively 85 ℃, and 92 ℃, 97 ℃, the time of each distillation is 40min;
(5) filter, concentrated, with water pill, dry, make treatment dysmenorrhea pill.
Embodiment 2
(1) by following weight portion, take raw material: 11 parts of Radix Angelicae Sinensis, 14 parts, Radix Rehmanniae Preparata, 4 parts of Rhizoma Chuanxiongs, 8 parts of the Radix Paeoniae Albas, 4 parts of Semen arachidis hypogaeaes, 4 parts of Fructus Jujubaes, 3 parts, Semen Phaseoli, 3 parts of Fructus Lyciis, 7 parts, brown sugar;
(2) whole raw material powders are broken into 250 order fine powders;
(3) add 10 times of water of raw material gross weight, regulate pH value to 4.5, add pectase, the cellulase of raw material gross weight 3% to carry out enzymolysis 24 hours, put into enzymatic vessel, controlling temperature is 65 ℃, and the weight ratio of pectase, cellulase is 3:4;
(4) enzymolysis medicine slurry step (2) being obtained carries out three air-distillations continuously, and the vapo(u)rizing temperature of three times is respectively 90 ℃, and 95 ℃, 100 ℃, the time of each distillation is 30min;
(5) filter, concentrated, with water pill, dry, make treatment dysmenorrhea pill.
Embodiment 3
(1) by following weight portion, take raw material: Radix Angelicae Sinensis 9,12 parts, Radix Rehmanniae Preparata, 6 parts of Rhizoma Chuanxiongs, 10 parts of the Radix Paeoniae Albas, 5 parts of Semen arachidis hypogaeaes, 3 parts of Fructus Jujubaes, 4 parts, Semen Phaseoli, 2 parts of Fructus Lyciis, 6 parts, brown sugar;
(2) whole raw material powders are broken into 300 order fine powders;
(3) add 8 times of water of raw material gross weight, regulate pH value to 5.0, add pectase, the cellulase of raw material gross weight 2% to carry out enzymolysis 18 hours, put into enzymatic vessel, controlling temperature is 55 ℃, and the weight ratio of pectase, cellulase is 3:4;
(4) enzymolysis medicine slurry step (2) being obtained carries out three air-distillations continuously, and the vapo(u)rizing temperature of three times is respectively 88 ℃, and 93 ℃, 98 ℃, the time of each distillation is 35min;
(5) filter, concentrated, with water pill, dry, make treatment dysmenorrhea pill.
Test example:
1, the present invention to women the clinical efficacy because of the dysmenorrhea that blood fortune is obstructed, blood deficiency causes
2, method of administration and the course for the treatment of
The oral embodiment of the present invention 1, embodiment 2, embodiment 3;
Each serving 0.45g, every day three times, within 15 days, be a course for the treatment of, its treatment is 2～3 courses for the treatment of.
3, select the standard of case
The patient of the dysmenorrhea because blood fortune is obstructed, blood deficiency causes is listed in to clinical observation object.
4, therapeutic evaluation
Cure: symptom disappears completely, and menstrual period are without significant discomfort.
Effective: symptom is improved, occasionally there is dysmenorrhea.
Invalid: symptom is without improvement, without positive effect.
5, result of the test
Table one embodiment 1, embodiment 2,3 couples of women of embodiment are because of the clinical observation of the dysmenorrhea that blood fortune is obstructed, blood deficiency causes
| ? | Patient/example | Healing/example | Effectively/example | Invalid/example | Effective percentage/% |
| Embodiment 1 | 323 | 111 | 189 | 23 | 92.9 |
| Embodiment 2 | 256 | 63 | 172 | 21 | 91.8 |
| Embodiment 3 | 234 | 66 | 150 | 18 | 92.3 |
Test shows that embodiment 1, embodiment 2,3 couples of women of embodiment transport dysmenorrhea obstructed, that blood deficiency causes because of blood and have significant therapeutic effect.
Claims (4)
1. a treatment dysmenorrhea pill, is characterized in that, is made: 7～11 parts of Radix Angelicae Sinensis, 8～14 parts, Radix Rehmanniae Preparata, 4～8 parts of Rhizoma Chuanxiongs, 8～12 parts of the Radix Paeoniae Albas, 4～6 parts of Semen arachidis hypogaeaes, 2～4 parts of Fructus Jujubaes, 3～5 parts, Semen Phaseoli, 1～3 part of Fructus Lycii, 5～7 parts, brown sugar by following weight portion raw material.
2. treatment dysmenorrhea pill according to claim 1, is characterized in that, by following weight portion raw material, is made: Radix Angelicae Sinensis 9,12 parts, Radix Rehmanniae Preparata, 6 parts of Rhizoma Chuanxiongs, 10 parts of the Radix Paeoniae Albas, 5 parts of Semen arachidis hypogaeaes, 3 parts of Fructus Jujubaes, 4 parts, Semen Phaseoli, 2 parts of Fructus Lyciis, 6 parts, brown sugar.
3. a preparation method for the treatment of dysmenorrhea pill, is characterized in that, preparation process is as follows:
(1) take raw material, and whole raw material powders are broken into 150～300 order fine powders;
(2) add 7～10 times of water of raw material gross weight, regulate pH value to 4.0～5.0, add pectase, the cellulase of raw material gross weight 1%～3% to carry out enzymolysis 12～24 hours, put into enzymatic vessel, controlling temperature is 40～55 ℃, and the weight ratio of pectase, cellulase is 3:4;
(3) enzymolysis medicine slurry step (2) being obtained carries out air-distillation;
(4) filter, concentrated, with water pill, dry, make treatment dysmenorrhea pill.
4. the preparation method for the treatment of dysmenorrhea pill according to claim 3, it is characterized in that: the described air-distillation of step (2) is carried out three times continuously, and the vapo(u)rizing temperature of three times is respectively 85～90 ℃, 92～95 ℃, 97～100 ℃, the time of each distillation is 30～40min.
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| CN201410292886.1A CN104027473A (en) | 2014-06-26 | 2014-06-26 | Pill for treating dysmenorrheal and preparation method of pill |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104587058A (en) * | 2014-12-29 | 2015-05-06 | 王琪 | Beverage for treating dysmenorrhea and preparation method thereof |
| CN106563034A (en) * | 2016-01-15 | 2017-04-19 | 中卫清华园生物科技有限公司 | Health-care medicine for treating uterus blood-stasis type dysmenorrhoea |
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| CN103211907A (en) * | 2013-02-04 | 2013-07-24 | 康美药业股份有限公司 | Siwu decoction formulated particles, and preparation method and detection method thereof |
| CN103285164A (en) * | 2013-06-24 | 2013-09-11 | 李江红 | Traditional Chinese medicine for treating dysmenorrhea |
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2014
- 2014-06-26 CN CN201410292886.1A patent/CN104027473A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103211907A (en) * | 2013-02-04 | 2013-07-24 | 康美药业股份有限公司 | Siwu decoction formulated particles, and preparation method and detection method thereof |
| CN103285164A (en) * | 2013-06-24 | 2013-09-11 | 李江红 | Traditional Chinese medicine for treating dysmenorrhea |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104587058A (en) * | 2014-12-29 | 2015-05-06 | 王琪 | Beverage for treating dysmenorrhea and preparation method thereof |
| CN106563034A (en) * | 2016-01-15 | 2017-04-19 | 中卫清华园生物科技有限公司 | Health-care medicine for treating uterus blood-stasis type dysmenorrhoea |
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