CN113144139A

CN113144139A - Traditional Chinese medicine composition for treating cancer, preparation method and application thereof and traditional Chinese medicine product

Info

Publication number: CN113144139A
Application number: CN202110379528.4A
Authority: CN
Inventors: 刘瑞连; 刘文龙; 李鑫
Original assignee: HUNAN ACADEMY OF CHINESE MEDICINE; Hunan University of Chinese Medicine
Current assignee: HUNAN ACADEMY OF CHINESE MEDICINE; Hunan University of Chinese Medicine
Priority date: 2021-04-08
Filing date: 2021-04-08
Publication date: 2021-07-23

Abstract

The invention relates to the field of medicines, and discloses a traditional Chinese medicine composition for treating cancer, a preparation method and application thereof, and a traditional Chinese medicine product. The traditional Chinese medicine composition comprises the following raw material components in parts by mass: 10-100 parts of barbed skullcap herb, 10-100 parts of Chinese sage herb, 5-50 parts of manyleaf paris rhizome, 5-50 parts of gecko, 3-20 parts of scorpion, 5-100 parts of white ginseng, 10-100 parts of astragalus root, 5-50 parts of largehead atractylodes rhizome, 15-100 parts of poria cocos, 5-50 parts of Chinese date, 5-30 parts of medlar, 5-30 parts of glossy privet fruit, 5-50 parts of epimedium herb, 3-50 parts of ground beeltle, 5-50 parts of zedoary, 5-50 parts of fiveleaf akebia fruit, 5-50 parts of giant knotweed rhizome, 5-50 parts of rhizoma pinellinae praeparata, 5-50 parts of fried chicken's gizzard-membrane and 5-100 parts of cuttlebone. The Chinese medicinal composition has high use safety, has the effects of clearing heat and removing toxicity, promoting blood circulation to remove blood stasis, softening hardness to dissipate stagnation, relieving swelling and pain, invigorating spleen and replenishing qi, and strengthening body resistance to eliminate pathogenic factors by compatibility of the whole formula, and has an obvious effect of curing the cancer.

Description

Traditional Chinese medicine composition for treating cancer, preparation method and application thereof and traditional Chinese medicine product

Technical Field

The invention relates to the field of medicines, in particular to a traditional Chinese medicine composition for treating cancer, a preparation method and application thereof and a traditional Chinese medicine product.

Background

China is a big cancer country in the world, the incidence rate of lung cancer, gastric cancer, breast cancer, liver cancer, esophageal cancer, colorectal cancer and the like is high, the cancer becomes one of the leading causes of death of Chinese people, the health life caused by the cancer is shortened by nearly twice of the average level in the world, and the speed is increased rapidly. The cost of cancer treatment is also rapidly increasing, placing a huge burden on society and families.

Cancer, namely malignant tumor, is also a big problem in medical customs in the world at present, and the existing medicines for treating cancer can be divided into western medicines and traditional Chinese medicines. Western medicine treatment of cancer is mainly comprehensive treatment including surgery, radiotherapy, chemotherapy, molecular targeted therapy, endocrine therapy, immunotherapy, etc., but all have limitations and disadvantages: not only has high cost, but also has great harm to the body, brings great pain to patients, further reduces the resistance of the patients, and ensures that the cancer is relapsed and metastasized after treatment. Moreover, the operation or the radiotherapy and the chemotherapy do not start from the etiology of the disease, and treat the symptoms and root causes.

The traditional Chinese medicine has the characteristics of channel tropism, is equivalent to the target treatment effect of western medicine theory, has unique effect on treating tumors by part of medicines, and has the advantages of less side effect, low treatment cost and wide application range. The Chinese has rich traditional Chinese medicine resources, and the vigorous development of the traditional Chinese medicine for treating the tumor is a new way to be developed urgently.

Disclosure of Invention

Aiming at the defects in the prior art, the invention aims to provide the traditional Chinese medicine composition for treating the cancer, the preparation method and the application thereof and the traditional Chinese medicine product obtained from the traditional Chinese medicine composition.

In order to achieve the above purpose, the first aspect of the present invention provides a traditional Chinese medicine composition for treating cancer, which comprises the following raw material components, by mass: 10-100 parts of barbed skullcap herb, 10-100 parts of Chinese sage herb, 5-50 parts of manyleaf paris rhizome, 5-50 parts of gecko, 3-20 parts of scorpion, 5-100 parts of white ginseng, 10-100 parts of astragalus root, 5-50 parts of largehead atractylodes rhizome, 15-100 parts of poria cocos, 5-50 parts of Chinese date, 5-30 parts of medlar, 5-30 parts of glossy privet fruit, 5-50 parts of epimedium herb, 3-50 parts of ground beeltle, 5-50 parts of zedoary, 5-50 parts of fiveleaf akebia fruit, 5-50 parts of giant knotweed rhizome, 5-50 parts of rhizoma pinellinae praeparata, 5-50 parts of fried chicken's gizzard-membrane and 5-100 parts of cuttlebone.

Preferably, the traditional Chinese medicine composition comprises the following raw material components in parts by mass: 15-60 parts of barbed skullcap herb, 15-60 parts of Chinese sage herb, 5-20 parts of manyleaf paris rhizome, 5-20 parts of gecko, 3-12 parts of scorpion, 5-20 parts of white ginseng, 15-60 parts of astragalus root, 7.5-22.5 parts of largehead atractylodes rhizome, 15-60 parts of tuckahoe, 5-20 parts of Chinese date, 7.5-22.5 parts of medlar, 7.5-22.5 parts of glossy privet fruit, 5-20 parts of epimedium herb, 3-12 parts of ground beeltle, 5-20 parts of zedoary, 7.5-22.5 parts of fiveleaf akebia fruit, 7.5-22.5 parts of giant knotweed rhizome, 5-20 parts of rhizoma pinellinae praeparata, 7.5-22.5 parts of fried chicken gizzard-membrane and 7.5-22.5 parts of cuttlebone.

The second aspect of the invention provides a preparation method of a traditional Chinese medicine composition for treating cancer, which comprises the following steps:

(1) mixing herba Scutellariae Barbatae, herba Salviae chinensis, rhizoma paridis, Gekko Swinhonis, Scorpio, radix Ginseng alba, radix astragali, rhizoma Atractylodis Macrocephalae, Poria, fructus Jujubae, fructus Lycii, fructus Ligustri Lucidi, herba Epimedii, Eupolyphaga Seu Steleophaga, rhizoma Curcumae, fructus Akebiae, rhizoma Polygoni Cuspidati, rhizoma Pinelliae Preparata, endothelium corneum Gigeriae Galli preparata, and Endoconcha Sepiae with water, decocting for 1-3 times, filtering, and mixing filtrates to obtain water extract;

(2) concentrating the water extract to obtain the traditional Chinese medicine composition;

wherein the dosage of the raw materials is as follows by mass: 10-100 parts of barbed skullcap herb, 10-100 parts of Chinese sage herb, 5-50 parts of manyleaf paris rhizome, 5-50 parts of gecko, 3-20 parts of scorpion, 5-100 parts of white ginseng, 10-100 parts of astragalus root, 5-50 parts of largehead atractylodes rhizome, 15-100 parts of poria cocos, 5-50 parts of Chinese date, 5-30 parts of medlar, 5-30 parts of glossy privet fruit, 5-50 parts of epimedium herb, 3-50 parts of ground beeltle, 5-50 parts of zedoary, 5-50 parts of fiveleaf akebia fruit, 5-50 parts of giant knotweed rhizome, 5-50 parts of rhizoma pinellinae praeparata, 5-50 parts of fried chicken's gizzard-membrane and 5-100 parts of cutt.

Preferably, in each decocting and extracting process in the step (1), the mass ratio of the total mass of the raw materials to the water is 1: 5-10.

Preferably, the decoction extraction process in the step (1) comprises mixing the raw materials with water, soaking for 0-2h, and boiling for 1-2 h.

Preferably, the concentration process in step (2) comprises concentrating the aqueous extract to an extract having a density of 1.3-1.4g/mL at 50 ℃.

The third aspect of the invention provides the traditional Chinese medicine composition prepared by the method.

The fourth aspect of the present invention provides an application of the above-mentioned traditional Chinese medicine composition or the traditional Chinese medicine composition prepared by the above-mentioned method in preparing a medicine for treating cancer.

The fifth aspect of the invention provides a traditional Chinese medicine product for treating cancer, and the active ingredients of the traditional Chinese medicine product are the traditional Chinese medicine composition or the traditional Chinese medicine composition prepared by the method.

Preferably, the dosage form of the traditional Chinese medicine product is soft extract, decoction, mixture, oral liquid, granules, pills, tablets and capsules.

Through the technical scheme, the invention has the beneficial effects that:

the traditional Chinese medicine composition provided by the invention has scientific and excellent formula, in the formula, the sculellaria barbata has the effects of clearing heat, removing toxicity and removing blood stasis, the Chinese sage herb has the effects of promoting blood circulation, removing blood stasis, removing toxicity and eliminating stagnation, the paris rhizome has the effects of clearing heat, removing toxicity, relieving swelling and pain, the gecko has the effects of removing toxicity and eliminating stagnation, the scorpion has the effects of dredging collaterals, relieving pain, attacking toxin and eliminating stagnation, and the five medicines have the effects of clearing heat, removing toxicity, eliminating stagnation, removing blood stasis, relieving swelling and relieving pain and are monarch medicines; white ginseng can greatly tonify primordial qi, tonify spleen and benefit lung, astragalus tonify qi and raise yang, bighead atractylodes rhizome can invigorate spleen and tonify qi, poria cocos can invigorate spleen, Chinese date can tonify middle-jiao and qi, five medicines can tonify spleen and qi, medlar, glossy privet fruit, herba epimedii and the like can nourish liver and kidney, and the eight medicines can support vital qi and invigorate yang, so that the effect of removing evil by monarch medicines is enhanced, and the white ginseng is used as a ministerial medicine; the five-flavor adjuvant monarch and ministerial medicine is an adjuvant medicine; endothelium corneum Gigeriae Galli preparata has effects of invigorating stomach, resolving food stagnation, and stopping bleeding by astringing Os Sepiae as guiding drug; the whole formula of the medicine has essential compatibility, tonification without stagnation, cleaning without depression, and attack and tonification with the same function, treats both symptoms and root causes, and has the functions of clearing heat and detoxicating, promoting blood circulation and removing blood stasis, softening hardness and dissipating stagnation, reducing swelling and relieving pain, strengthening spleen and replenishing qi, and strengthening body resistance and eliminating evil together, so the traditional Chinese medicine composition can improve the immunity of a patient, inhibit or kill cancer cells and eliminate cancers; after long-term clinical use, no toxic or side effect is seen on the human body.

Detailed Description

The endpoints of the ranges and any values disclosed herein are not limited to the precise range or value, and such ranges or values should be understood to encompass values close to those ranges or values. For ranges of values, between the endpoints of each of the ranges and the individual points, and between the individual points may be combined with each other to give one or more new ranges of values, and these ranges of values should be considered as specifically disclosed herein.

In a first aspect, the invention provides a traditional Chinese medicine composition for treating cancer, which comprises the following raw material components in parts by mass: 10-100 parts of barbed skullcap herb, 10-100 parts of Chinese sage herb, 5-50 parts of manyleaf paris rhizome, 5-50 parts of gecko, 3-20 parts of scorpion, 5-100 parts of white ginseng, 10-100 parts of astragalus root, 5-50 parts of largehead atractylodes rhizome, 15-100 parts of poria cocos, 5-50 parts of Chinese date, 5-30 parts of medlar, 5-30 parts of glossy privet fruit, 5-50 parts of epimedium herb, 3-50 parts of ground beeltle, 5-50 parts of zedoary, 5-50 parts of fiveleaf akebia fruit, 5-50 parts of giant knotweed rhizome, 5-50 parts of rhizoma pinellinae praeparata, 5-50 parts of fried chicken's gizzard-membrane and 5-100 parts of cuttlebone.

The pharmacological analysis of the selected raw materials of the invention is as follows:

sculellaria barbata is dry whole herb of Scutellaria barbata D.Don of Labiatae, and is pungent, bitter and cold in taste. Clearing away heat and toxic material, removing blood stasis and promoting urination, and can be used for treating furuncle, swelling and pain of throat, traumatic injury, edema, jaundice, snake and insect bite.

Herba Salviae chinensis is the whole herb of Salvia chinensis Benth of Labiatae, bitter and pungent. Promoting blood circulation, removing blood stasis, removing toxic substance, and resolving hard mass, and can be used for treating dysphagia, asthma, innominate swelling and pain, lymphoid tuberculosis, hepatitis, and leucorrhea with reddish discharge.

Rhizoma paridis is the rhizome of Paris polyphylla Smith and Paris polyphylla Smith of Liliaceae. Clearing away heat and toxic material, relieving swelling and pain, cooling liver and arresting convulsion, and can be used for treating furuncle, carbuncle, swelling and sore throat, snake and insect bite, traumatic injury, convulsion, etc.

Gekko Swinhonis (Gekko Swinhonis) is salty in taste and cold in nature. Dispelling pathogenic wind and arresting convulsion, removing toxic substance and resolving hard mass, and can be used for treating rheumatalgia, limb paralysis, epilepsy, tetanus, lymphoid tuberculosis, dysphagia, and cancer.

Dried body of Buthus martensii Karsch belonging to Buthus martensii of Buthus martensii Scorpion family. Wind-extinguishing, spasm-relieving, collateral-dredging, pain-relieving, toxic-counteracting and nodulation-dissipating, and can be used for stirring of liver-wind, spasm and convulsion, infantile convulsion and apoplexy

Hemiplegia, tetanus, stubborn rheumatism, migraine, sore and ulcer, scrofula.

The white ginseng can greatly tonify primordial qi, recover pulse, strengthen spleen, benefit lung, promote the production of body fluid, nourish blood, calm nerves and benefit intelligence, and is used for treating weak body and desire to loose, cold limbs and a little pulse, spleen deficiency and poor appetite, lung deficiency and cough, body fluid deficiency and thirst, internal heat and thirst, deficiency of qi and blood, deficiency of vital energy and deficiency of vital energy, palpitation and insomnia, impotence and cold uterus.

The astragalus root is the root of astragalus mongholicus of leguminous plants, has sweet taste and mild nature, enters spleen and lung channels, and has the effects of tonifying qi and invigorating yang, consolidating superficial resistance and arresting sweating, inducing diuresis to alleviate edema, promoting the production of body fluid and nourishing blood, activating stagnancy and dredging paralysis, expelling toxin and pus, healing sores and promoting tissue regeneration. Can be used for treating deficiency of vital energy, asthenia, anorexia, loose stool, collapse of middle-warmer energy, chronic diarrhea, rectocele, hematochezia, spontaneous perspiration due to exterior deficiency, edema due to qi deficiency, internal heat, diabetes, blood deficiency, hemiplegia, arthralgia, numbness, carbuncle, cellulitis, and intractable ulcer.

Atractylodis rhizoma is dried rhizome of Atractylodes macrocephala Koidz of Compositae, and has effects of invigorating spleen and invigorating qi, eliminating dampness and promoting diuresis, arresting sweating, and preventing miscarriage, and can be used for treating spleen deficiency, anorexia, abdominal distention, diarrhea, phlegm retention, dizziness and palpitation, edema, spontaneous perspiration, and threatened abortion.

Poria is dried sclerotium of Wolf of Poria cocos (Schw.) belonging to Polyporaceae. Induce diuresis and drain dampness, invigorate spleen and calm heart, and can be used for edema, oliguria, palpitation, spleen deficiency, anorexia, loose stool, diarrhea, uneasiness, palpitation and insomnia.

The Chinese date has the effects of tonifying middle-jiao and Qi, nourishing blood and soothing nerves. Can be used for treating spleen deficiency, anorexia, asthenia, loose stool, and hysteria of women.

Fructus Lycii is mature fruit of Solanaceae plant fructus Lycii or Ningxia fructus Lycii, and has effects of nourishing liver and kidney, replenishing vital essence and improving eyesight. Can be used for treating consumptive disease and essence deficiency, soreness of waist and knees, giddiness and tinnitus, sexual impotence and nocturnal emission, internal heat and thirst, blood deficiency and sallow complexion, and blurred vision.

Fructus Ligustri Lucidi is fruit of Ligustrum lucidum belonging to Oleaceae. Nourishing liver and kidney, improving eyesight and blackening hair, and can be used for treating liver and kidney yin deficiency, giddiness, tinnitus, soreness of waist and knees, early white beard and hair, dim and unclear vision, internal heat, diabetes, and hectic fever.

Herba Epimedii has effects of invigorating kidney yang, strengthening tendons and bones, and dispelling pathogenic wind and dampness, and can be used for treating deficiency of kidney yang, sexual impotence, spermatorrhea, tendons and bones flaccidity, rheumatalgia, numbness and contracture.

The Eupolyphaga Seu Steleophaga is female dry body of Eupolyph, aga sin, nsis Walker or Steleophaga plancy (Boleny) of Eupolyphaga of Corynodidae. Break blood and remove stasis, reunion of fractured tendons and bones, used for traumatic injury, muscle injury and fracture, amenorrhea due to blood stasis, postpartum abdominal pain due to blood stasis, and mass.

The Curcumae rhizoma is dried rhizome of Curcuma zedoaria Curcuma phaeocaulis Val, Curcuma zedoaria Kwangsiensis S.G.Lee et C.F.Liang or Curcuma wenyujin Y.H.Chen et C.Ling. Move qi and break blood, resolve food stagnation and alleviate pain, and is used for abdominal mass, blood stasis and amenorrhea, chest stuffiness and pain, food stagnation and distending pain.

Fructus Akebiae is fruit of Akebiae, caulis Akebiae, and caulis Sinomenii. Soothing liver, regulating qi, promoting blood circulation, removing blood stasis, relieving pain, relieving restlessness and promoting urination, and can be used for treating liver and stomach qi pain, stomach heat, anorexia, polydipsia, dysentery with reddish urine, lumbago, hypochondriac pain, hernia, menopause and metrorrhagia.

The rhizoma Polygoni Cuspidati is dried rhizome and root of Polygonum cuspidatum Thunb. et Zucc. Removing dampness and jaundice, clearing heat and detoxicating, removing blood stasis and relieving pain, relieving cough and reducing phlegm, and can be used for treating damp-heat jaundice, stranguria with turbid urine, leukorrhagia, rheumatic arthralgia, carbuncle, sore, scald caused by water and fire, amenorrhea, abdominal mass, traumatic injury, and cough due to lung heat.

Rhizoma Pinelliae Preparata is processed from rhizoma Pinelliae Preparata. Eliminating dampness and phlegm, lowering adverse qi and relieving vomit, relieving stuffiness and resolving masses, and can be used for treating damp phlegm cold phlegm, cough with asthma, excessive phlegm, phlegm-fluid retention, dizziness and palpitation, wind phlegm vertigo, phlegm syncope, headache, emesis, regurgitation, stuffiness and stuffiness in chest and epigastrium, and globus hystericus; it is indicated for abscess with phlegm nodule.

The fried chicken's gizzard-membrane has the functions of invigorating stomach and promoting digestion, controlling nocturnal emission and relieving enuresis, and treating stranguria and removing calculus. Can be used for treating dyspepsia, emesis, dysentery, infantile malnutrition, enuresis, nocturnal emission, stranguria with stone, pain, gallbladder distention, and hypochondriac pain.

The Os Sepiae is dried inner shell of Sepiella maindroni DeRoehibrun or Sepia esculenta Hoyle of Sepiella maindroni of Sepielidae. Astringe to stop bleeding, astringe seminal emission and stop leucorrhea, relieve hyperacidity and pain, astringe dampness and heal wound, and can be used for hematemesis and epistaxis, metrorrhagia and hematochezia, spermatorrhea, leucorrhea with reddish discharge, stomach ache and acid regurgitation; it is used externally to treat traumatic hemorrhage, eczema and unhealed ulcer.

The traditional Chinese medicine composition has unique and reasonable compatibility, and the combination of the raw materials can clear away heat and toxic materials, relieve swelling and pain, promote blood circulation to remove blood stasis, soften hardness and dissipate stagnation, invigorate spleen and replenish qi, strengthen body resistance and eliminate evil, and improve the immunity of patients. After repeated research and optimization, the traditional Chinese medicine composition provided by the invention has good effect when being applied to clinical practice, and has obvious effect on treating various cancers such as lung cancer, liver cancer, rectal cancer and the like.

Preferably, the traditional Chinese medicine composition comprises the following raw material components in parts by mass: 15-60 parts of barbed skullcap herb, 15-60 parts of Chinese sage herb, 5-20 parts of manyleaf paris rhizome, 5-20 parts of gecko, 3-12 parts of scorpion, 5-20 parts of white ginseng, 15-60 parts of astragalus root, 7.5-22.5 parts of largehead atractylodes rhizome, 15-60 parts of tuckahoe, 5-20 parts of Chinese date, 7.5-22.5 parts of medlar, 7.5-22.5 parts of glossy privet fruit, 5-20 parts of epimedium herb, 3-12 parts of ground beeltle, 5-20 parts of zedoary, 7.5-22.5 parts of fiveleaf akebia fruit, 7.5-22.5 parts of giant knotweed rhizome, 5-20 parts of rhizoma pinellinae praeparata, 7.5-22.5 parts of fried chicken gizzard-membrane and 7.5-22.5 parts of cuttlebone. According to the conditions of constitution, disease symptoms and the like of patients, the raw materials of each traditional Chinese medicine can be adjusted within the given part range, and proper numerical values are taken to achieve the best treatment effect.

In a second aspect, the present invention provides a method for preparing a Chinese medicinal composition for treating cancer, comprising the following steps:

wherein the dosage of the raw materials is as follows by mass: 10-100 parts of barbed skullcap herb, 10-100 parts of Chinese sage herb, 5-50 parts of manyleaf paris rhizome, 5-50 parts of gecko, 3-20 parts of scorpion, 5-100 parts of white ginseng, 10-100 parts of astragalus root, 5-50 parts of largehead atractylodes rhizome, 15-100 parts of poria cocos, 5-50 parts of Chinese date, 5-30 parts of medlar, 5-30 parts of glossy privet fruit, 5-50 parts of epimedium herb, 3-50 parts of ground beeltle, 5-50 parts of zedoary, 5-50 parts of fiveleaf akebia fruit, 5-50 parts of giant knotweed rhizome, 5-50 parts of rhizoma pinellinae praeparata, 5-50 parts of fried chicken's gizzard-membrane and 5-100 parts of cuttlebone.

In the invention, the modes and equipment for decocting, filtering and concentrating are not specially limited, the filtering can be performed by filter pressing, suction filtration or other modes, and the concentrating can be performed by a concentrating tank or any other concentrating equipment.

Preferably, in each decocting and extracting process in the step (1), the mass ratio of the total mass of the raw materials to the water is 1: 5-10. The inventor finds that under the preferred embodiment, the scheme of the invention has the advantages of further improving the decoction extraction rate and simplifying the subsequent process.

The times of decoction and extraction in the invention can be set according to the specific extraction process and the raw material dosage, and the times of decoction and extraction of more than 3 times are not excluded. Preferably, the extract is decocted and extracted for 2-3 times. Further preferably, the decocting and extracting process in the step (1) comprises mixing the raw materials with water, soaking for 0-2h, and boiling for 1-2 h. The preferred embodiment is beneficial to improving the extraction efficiency of the effective components in the raw materials, and specifically, the soaking time in the decoction extraction process can be 0.5h, 1h, 1.5h, 2h, or any value between the two values; the boiling time may be 1h, 1.2h, 1.4h, 1.6h, 1.8h, 2h, or any value in between.

Preferably, the concentration process in step (2) comprises concentrating the aqueous extract to an extract having a density of 1.3-1.4g/mL at 50 ℃. The preferred embodiment increases the density of the Chinese medicinal composition through the concentration process, is beneficial to reducing the dosage of patients, and is convenient for packaging and transportation.

In a third aspect, the invention provides a traditional Chinese medicine composition prepared by the method.

In a fourth aspect, the invention provides an application of the above traditional Chinese medicine composition or the traditional Chinese medicine composition prepared by the above method in preparing a medicine for treating cancer.

In a fifth aspect, the invention provides a traditional Chinese medicine product for treating cancer, and the active ingredients of the traditional Chinese medicine product are the traditional Chinese medicine composition or the traditional Chinese medicine composition prepared by the method.

Preferably, the dosage form of the traditional Chinese medicine product is soft extract, decoction, mixture, oral liquid, granules, pills, tablets and capsules. The traditional Chinese medicine product is prepared into a soft extract, a decoction, a mixture, oral liquid, granules, pills, tablets and capsules by adding the traditional Chinese medicine composition with conventional auxiliary materials.

The present invention will be described in detail below by way of examples.

In the following examples, Scutellaria barbata, Chinese sage herb, manyleaf paris rhizome, gecko, scorpion, white ginseng, astragalus, largehead atractylodes rhizome, tuckahoe, Chinese date, medlar, glossy privet fruit, herba epimedii, ground beeltle, zedoary, fiveleaf akebia fruit, giant knotweed rhizome, rhizoma pinellinae praeparata, fried chicken's gizzard-membrane and cuttlebone are products processed by Hunan kernel Shangyuan traditional Chinese medicine decoction pieces Limited company.

Example 1

(1) Weighing 30g of barbed skullcap herb, 30g of Chinese sage herb, 10g of manyleaf paris rhizome, 10g of gecko, 6g of scorpion, 10g of white ginseng, 30g of astragalus root, 15g of bighead atractylodes rhizome, 30g of tuckahoe, 15g of medlar, 15g of glossy privet fruit, 10g of epimedium herb, 6g of ground beeltle, 10g of zedoary, 15g of akebia fruit, 15g of giant knotweed rhizome, 10g of rhizoma pinellinae praeparata, 15g of fried chicken gizzard-membrane, 15g of cuttlebone and 10g of Chinese date;

(2) mixing the raw materials weighed in the step (1) with 2456g of water, soaking for 1h, boiling for 2h, filtering to obtain a first filtrate and dregs, mixing the dregs with 1842g of water, boiling for 1.5h, filtering to obtain a second filtrate, combining the first filtrate and the second filtrate, and concentrating under reduced pressure to obtain an extract with the density of 1.35g/mL at 50 ℃, thus obtaining the traditional Chinese medicine composition as a traditional Chinese medicine extract product.

Example 2

(1) Weighing 60g of barbed skullcap herb, 60g of Chinese sage herb, 20g of manyleaf paris rhizome, 20g of gecko, 12g of scorpion, 20g of white ginseng, 60g of astragalus root, 22.5g of largehead atractylodes rhizome, 60g of tuckahoe, 22.5g of medlar, 22.5g of glossy privet fruit, 20g of epimedium herb, 12g of ground beeltle, 20g of zedoary, 22.5g of fiveleaf akebia fruit, 22.5g of giant knotweed rhizome, 20g of rhizoma pinellinae praeparata, 22.5g of fried chicken's gizzard-membrane, 22.5g of cuttlebone and 20g of Chinese date;

(2) mixing the raw materials weighed in the step (1) with 5615g of water, soaking for 2h, boiling for 2h, and filtering to obtain a first filtrate and first medicine residue; mixing the first residue with 4492g of water, boiling for 1.5h, and filtering to obtain a second filtrate and a second residue; mixing the second residue with 2807.5g water, boiling for 1 hr, and filtering to obtain third filtrate; mixing the three filtrates, concentrating under reduced pressure to obtain extract with density of 1.4g/mL at 50 deg.C to obtain Chinese medicinal composition, adding conventional amount of starch and other adjuvants, mixing, and making into pill.

Example 3

(1) Weighing 15g of barbed skullcap herb, 15g of Chinese sage herb, 5g of manyleaf paris rhizome, 5g of gecko, 3g of scorpion, 5g of white ginseng, 15g of astragalus root, 7.5g of largehead atractylodes rhizome, 15g of tuckahoe, 7.5g of medlar, 7.5g of glossy privet fruit, 5g of epimedium herb, 3g of ground beeltle, 5g of zedoary, 7.5g of fiveleaf akebia fruit, 7.5g of giant knotweed rhizome, 5g of rhizoma pinellinae praeparata, 7.5g of fried chicken's gizzard-membrane, 7.5g of cuttlebone and 5g of Chinese date;

(2) mixing the raw materials weighed in the step (1) with 1228g of water, soaking for 0.5h, boiling for 2h, and filtering to obtain a first filtrate and dregs; mixing the residues with 982g of water, boiling for 1.5h, filtering to obtain a second filtrate, mixing the first filtrate and the second filtrate, concentrating under reduced pressure to obtain an extract with a density of 1.3g/mL at 50 ℃ to obtain a traditional Chinese medicine composition, adding conventional amount of starch and other auxiliary materials, mixing uniformly, and granulating to obtain a traditional Chinese medicine granule product.

Example 4

(1) Weighing 100g of barbed skullcap herb, 100g of Chinese sage herb, 50g of manyleaf paris rhizome, 50g of gecko, 20g of scorpion, 100g of white ginseng, 100g of astragalus root, 50g of largehead atractylodes rhizome, 100g of tuckahoe, 30g of medlar, 30g of glossy privet fruit, 50g of epimedium herb, 50g of ground beeltle, 50g of zedoary, 50g of akebia fruit, 50g of giant knotweed rhizome, 50g of rhizoma pinellinae praeparata, 50g of fried chicken's gizzard-membrane, 100g of cuttlebone and 50g of Chinese date;

(2) mixing the raw materials weighed in the step (1) with 9.84kg of water, soaking for 2h, boiling for 1h, filtering to obtain a first filtrate and dregs, mixing the dregs with 7.38kg of water, boiling for 2h, filtering to obtain a second filtrate, combining the first filtrate and the second filtrate, concentrating under reduced pressure to obtain an extract with the density of 1.35g/mL at 50 ℃, preparing a traditional Chinese medicine composition, adding conventional amount of auxiliary materials such as crystal sugar and the like, and uniformly mixing to obtain a traditional Chinese medicine oral liquid product.

Example 5

(1) Weighing 10g of barbed skullcap herb, 10g of Chinese sage herb, 5g of manyleaf paris rhizome, 5g of gecko, 3g of scorpion, 5g of white ginseng, 10g of astragalus root, 5g of bighead atractylodes rhizome, 15g of tuckahoe, 5g of medlar, 5g of glossy privet fruit, 5g of epimedium herb, 3g of ground beeltle, 5g of zedoary, 5g of akebia fruit, 5g of giant knotweed rhizome, 5g of rhizoma pinellinae praeparata, 5g of fried chicken's gizzard-membrane, 5g of cuttlebone and 5g of Chinese date;

(2) mixing the raw materials weighed in the step (1) with 726g of water, soaking for 1h, boiling for 1.5h, filtering to obtain a first filtrate and dregs, mixing the dregs with 605g of water, boiling for 2h, filtering to obtain a second filtrate, combining the first filtrate and the second filtrate, concentrating under reduced pressure to obtain an extract with the density of 1.35g/mL at 50 ℃, preparing the traditional Chinese medicine composition, adding conventional amount of starch and other auxiliary materials, uniformly mixing, and tabletting to obtain a traditional Chinese medicine tablet product.

Clinical data

The curative effect of the Chinese medicinal composition is illustrated by clinical data as follows:

1. clinical observations

1000 patients with confirmed cancer were treated with the traditional Chinese medicine composition as a test group by receiving and tracking 1000 patients who had confirmed cancer in a hospital affiliated with the traditional Chinese medicine research institute in Hunan province from 2010 to 2020, wherein 300 patients with liver cancer, 300 patients with lung cancer, 100 patients with stomach cancer, 200 patients with rectal cancer, 50 patients with breast cancer, and 50 patients with cervical cancer; 1000 cancer patients treated with chemotherapeutic drugs were also collected as a control group.

2. Method of treatment

The taking method comprises the following steps: the Chinese medicinal products prepared in the embodiments 1 to 5 of the invention are taken by a test group or each Chinese medicinal raw material is adjusted to be a proper numerical value according to the conditions of the physique, the symptoms and the like of a patient, the Chinese medicinal raw materials are taken twice a day, 1 month is taken as a treatment course, generally three treatment courses are taken, and other medicaments are not taken during the treatment course; the comparison group is injected with drugs such as mitomycin or cisplatin, adriamycin and the like, and the patients do relevant examination and detailed record before and after treatment.

Diet contraindication: it should not be taken with other Chinese medicinal materials, and should not be drunk with wine or spicy food.

3. The curative effect standard is as follows:

remarkably: after the medicine is taken, the body can recover better; b ultrasonic examination, CT examination and the like: the tumor is obviously reduced or disappeared, and the assay index is obviously improved;

the method has the following advantages: after the medicine is taken, the symptoms are improved, and the tumor examination is not developed;

and (4) invalidation: after taking the medicine, the improvement is not caused compared with that before taking the medicine, and the tumor becomes larger.

4. The curative effect results are as follows:

group of	Total number of people	Number of significant people	Number of effective persons	Number of invalid persons
					Test group	1000	200	600	200
Comparison group	1000	100	400	500

5. Partial case data:

case 1: a certain Wang, a female, aged 55 years, is diagnosed as lung cancer in hospitals, and the disease recurs after 1 operation treatment in tumor hospitals in Hunan province; after the patient starts to take the traditional Chinese medicine composition in 2015, 10 and 11 days and takes the traditional Chinese medicine composition continuously for 6 months, the result lumps become obviously smaller, and the patient takes the traditional Chinese medicine composition continuously for 24 months and stops taking the traditional Chinese medicine composition until the body is good.

Case 2: when a person in a certain forest is male and is 59 years old, and the lung cancer is advanced, no operation pointer exists, the traditional Chinese medicine composition is taken on 11, 9 and 11 months of 2015, energy and physical strength begin to recover after 1 month, the effect is obvious after the person is continuously taken for 24 months, and the physical condition is still acceptable at present.

Case 3: when a certain woman in 54 years old is diagnosed as lung cancer in a hospital, the disease recurs after 1 operation treatment in a tumor hospital in Hunan province; after the patient starts to take the traditional Chinese medicine composition in 2016, 6 and 10 months and continuously takes the traditional Chinese medicine composition for 6 months, the result lumps are obviously reduced, and the patient continuously takes the traditional Chinese medicine composition for 24 months and stops taking the traditional Chinese medicine composition until the body is good.

Case 4: a certain Liu is female, 50 years old, and early in breast cancer, and patients are not treated by operation, the traditional Chinese medicine composition is taken at 2016, 7, 11 and 6 months later, the result lumps are obviously reduced after the traditional Chinese medicine composition is taken for a second time, and the patients are good until the medicine is stopped for 24 months.

Case 5: when a certain plum is born by 53 years old and male, the clinical diagnosis shows that the liver cancer is early, the patient does not have the operation treatment, the traditional Chinese medicine composition is taken at 10, 9 and 2016, the energy and the physical strength begin to recover after 1 month, the effect is obvious after the patient continuously takes the traditional Chinese medicine composition for 24 months, and the physical condition is still available at present.

Case 6: after taking the traditional Chinese medicine composition for 2016, 10, 9 and 9 days, the energy and the physical strength begin to recover after 1 month, the effect is obvious after continuously taking for 6 months, and after continuously taking for 1 year, the body recovers well and is followed up, so that the current physical condition is still clear.

Case 7: in the middle stage of intestinal cancer, a male is in the age of 48, and the traditional Chinese medicine research institute in Hunan province is subjected to surgery, two courses of chemotherapy are performed after the surgery, the traditional Chinese medicine composition is taken 5 and 9 days in 2017, energy is recovered after 1 month, the effect is obvious after 24 months of continuous taking, follow-up visits are made, and the current physical condition is still clear.

Case 8: when a certain yellow wine is taken by a woman in the age of 59 years and in the early stage of lung cancer, the patient refuses surgical treatment, the traditional Chinese medicine composition is taken at 8, 9 and 2017, the energy and the physical strength begin to recover after 1 month, the effect is obvious after the patient continuously takes the traditional Chinese medicine composition for 24 months, and the physical condition is still available at present after follow-up.

The traditional Chinese medicine composition disclosed by the invention is good in curative effect through clinical verification, can improve the immune function of a human body, and has the effects of relieving pain and reducing lumps in the treatment of cancer. The traditional Chinese medicine composition has no obvious toxic or side effect, and after a patient takes the medicine, the abnormal change caused by taking the traditional Chinese medicine composition is not found in routine examination of liver and kidney functions, blood routine, excrement and urine and the like of the patient, so that the traditional Chinese medicine composition is worthy of clinical popularization and application.

The preferred embodiments of the present invention have been described above in detail, but the present invention is not limited thereto. Within the scope of the technical idea of the invention, many simple modifications can be made to the technical solution of the invention, including combinations of various technical features in any other suitable way, and these simple modifications and combinations should also be regarded as the disclosure of the invention, and all fall within the scope of the invention.

Claims

1. The traditional Chinese medicine composition for treating cancer is characterized by comprising the following raw material components in parts by mass: 10-100 parts of barbed skullcap herb, 10-100 parts of Chinese sage herb, 5-50 parts of manyleaf paris rhizome, 5-50 parts of gecko, 3-20 parts of scorpion, 5-100 parts of white ginseng, 10-100 parts of astragalus root, 5-50 parts of largehead atractylodes rhizome, 15-100 parts of poria cocos, 5-50 parts of Chinese date, 5-30 parts of medlar, 5-30 parts of glossy privet fruit, 5-50 parts of epimedium herb, 3-50 parts of ground beeltle, 5-50 parts of zedoary, 5-50 parts of fiveleaf akebia fruit, 5-50 parts of giant knotweed rhizome, 5-50 parts of rhizoma pinellinae praeparata, 5-50 parts of fried chicken's gizzard-membrane and 5-100 parts of cuttlebone.

2. The traditional Chinese medicine composition according to claim 1, which is characterized by comprising the following raw material components in parts by mass: 15-60 parts of barbed skullcap herb, 15-60 parts of Chinese sage herb, 5-20 parts of manyleaf paris rhizome, 5-20 parts of gecko, 3-12 parts of scorpion, 5-20 parts of white ginseng, 15-60 parts of astragalus root, 7.5-22.5 parts of largehead atractylodes rhizome, 15-60 parts of tuckahoe, 5-20 parts of Chinese date, 7.5-22.5 parts of medlar, 7.5-22.5 parts of glossy privet fruit, 5-20 parts of epimedium herb, 3-12 parts of ground beeltle, 5-20 parts of zedoary, 7.5-22.5 parts of fiveleaf akebia fruit, 7.5-22.5 parts of giant knotweed rhizome, 5-20 parts of rhizoma pinellinae praeparata, 7.5-22.5 parts of fried chicken gizzard-membrane and 7.5-22.5 parts of cuttlebone.

3. A preparation method of a traditional Chinese medicine composition for treating cancer is characterized by comprising the following steps:

4. The method according to claim 3, wherein in each decocting extraction process in the step (1), the mass ratio of the total mass of the raw materials to the water is 1: 5-10.

5. The method of claim 3, wherein the decocting and extracting process in step (1) comprises mixing the raw materials with water, soaking for 0-2h, and boiling for 1-2 h.

6. The method as claimed in claim 3, wherein the concentration process in step (2) comprises concentrating the aqueous extract to an extract having a density of 1.3-1.4g/mL at 50 ℃.

7. A Chinese medicinal composition prepared according to any one of claims 3 to 6.

8. Use of the Chinese medicinal composition of claim 1 or 2 or the Chinese medicinal composition prepared by the method of any one of claims 3 to 6 in the preparation of a medicament for treating cancer.

9. A traditional Chinese medicine product for treating cancer, which is characterized in that the active ingredient of the traditional Chinese medicine product is the traditional Chinese medicine composition of claim 1 or 2 or the traditional Chinese medicine composition prepared by the method of any one of claims 3 to 6.

10. The traditional Chinese medicine product for treating cancer according to claim 9, wherein the dosage form of the traditional Chinese medicine product is a soft extract, a decoction, a mixture, an oral liquid, granules, pills, tablets, capsules.