CN113230377A - Traditional Chinese medicine electuary for treating wind-cold type common cold and preparation method thereof - Google Patents

Traditional Chinese medicine electuary for treating wind-cold type common cold and preparation method thereof Download PDF

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CN113230377A
CN113230377A CN202110666456.1A CN202110666456A CN113230377A CN 113230377 A CN113230377 A CN 113230377A CN 202110666456 A CN202110666456 A CN 202110666456A CN 113230377 A CN113230377 A CN 113230377A
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parts
cold
traditional chinese
chinese medicine
root
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王晓兵
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/538—Schizonepeta
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    • A61K36/18—Magnoliophyta (angiosperms)
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Abstract

The invention discloses traditional Chinese medicine granules for treating common cold due to wind-cold, which are prepared from the following raw material medicines in parts by weight: 7 parts of schizonepeta, 6 parts of honey-fried licorice root, 2 parts of dried ginger, 7 parts of divaricate saposhnikovia root, 7 parts of angelica dahurica, 8 parts of platycodon grandiflorum, 7 parts of notopterygium root, 8 parts of fermented soya beans, 7 parts of ephedra, 10 parts of perilla leaf, 8 parts of cassia twig, 7 parts of centipeda minima, 12 parts of blackberry lily, 3 parts of asarum, 9 parts of almond, 10 parts of radix bupleuri, 3 parts of agastache rugosus, 9 parts of gypsum, 9 parts of houttuynia cordata, 7 parts of eupatorium and 12 parts of poria cocos. The traditional Chinese medicine electuary for treating wind-cold type common cold is prepared by scientifically combining traditional Chinese medicine raw materials which are used as both medicine and food, has no toxic or side effect, is safe and reliable, can effectively treat wind-cold type common cold, has the effects of relieving exterior syndrome and dispelling cold, ventilating and smoothing lung with acrid substance, and relieving pain, is short in treatment course, quick in effect, safe, effective, low in price, convenient to use, and can obtain better economic and social benefits after popularization and application.

Description

Traditional Chinese medicine electuary for treating wind-cold type common cold and preparation method thereof
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to traditional Chinese medicine electuary for treating wind-cold type common cold and a preparation method thereof.
Background
Common cold is a common exogenous disease in four seasons, and is characterized by nasal obstruction, watery nasal discharge, sneezing, headache, fever and the like, and is common in all four seasons, namely in winter and spring. The mild case is called cold; the severe one is called severe cold or influenza.
At present, a plurality of medicines for treating cold are available, and the Chinese patent medicine is favored by people due to the characteristics of small side effect and good curative effect. Chinese families all have Chinese patent medicines for treating cold, but practice proves that some people have taken a lot of medicines after suffering from cold, but the symptoms are not alleviated, and the key point is that no medicine is taken according to syndrome differentiation. The etiology, symptoms, treatment principles and medication of different types of cold are very different. The cold is divided into four types of wind-cold type cold, wind-heat type cold, summer-heat and damp type cold and influenza (influenza) in traditional Chinese medicine. According to the principle of treatment based on syndrome differentiation, different Chinese patent medicines are selected for treating different types of cold. Wind-cold type common cold is caused by the invasion of pathogenic wind-cold and the failure of lung-qi to disperse. Symptoms are visible: severe aversion to cold, mild fever, no sweat, headache, body pain, nasal obstruction, clear nasal discharge, cough, thin and white sputum, thirst, hot drink preference, and thin and white tongue coating. At present, the domestic cold medicine market mainly treats wind-heat type cold and influenza, and relatively few traditional Chinese medicine preparations for treating wind-heat type cold are available.
Disclosure of Invention
The invention aims to make up the defects of the prior art, and provides traditional Chinese medicine granules for treating wind-cold type common cold and a preparation method thereof, wherein the traditional Chinese medicine granules have the effects of dispelling cold, relieving exterior syndrome, dredging orifices and relieving pain, and have short treatment course and quick response.
The invention is realized by the following technical scheme:
a traditional Chinese medicine electuary for treating common cold due to wind-cold is prepared from the following raw material medicines in parts by weight:
3-9 parts of schizonepeta, 6-8 parts of honey-fried licorice root, 2-3 parts of dried ginger, 3-9 parts of divaricate saposhnikovia root, 3-9 parts of dahurian angelica root, 5-10 parts of platycodon root, 3-9 parts of notopterygium root, 3-10 parts of fermented soya beans, 3-9 parts of ephedra herb, 8-11 parts of perilla leaf, 6-10 parts of cassia twig, 3-9 parts of centipeda minima, 10-14 parts of blackberry lily, 2-4 parts of asarum, 6-12 parts of almond, 8-12 parts of radix bupleuri, 3-4 parts of wrinkled gianthyssop herb, 8-10 parts of gypsum, 6-15 parts of houttuynia cordata, 3-9 parts of fortune eupatorium herb and 10-12 parts of poria cocos.
The traditional Chinese medicine electuary is prepared from the following raw material medicines in parts by weight:
7 parts of schizonepeta, 6 parts of honey-fried licorice root, 2 parts of dried ginger, 7 parts of divaricate saposhnikovia root, 7 parts of angelica dahurica, 8 parts of platycodon grandiflorum, 7 parts of notopterygium root, 8 parts of fermented soya beans, 7 parts of ephedra, 10 parts of perilla leaf, 8 parts of cassia twig, 7 parts of centipeda minima, 12 parts of blackberry lily, 3 parts of asarum, 9 parts of almond, 10 parts of radix bupleuri, 3 parts of agastache rugosus, 9 parts of gypsum, 9 parts of houttuynia cordata, 7 parts of eupatorium and 12 parts of poria cocos.
A preparation method of traditional Chinese medicine electuary for treating common cold due to wind-cold comprises the following specific steps:
(1) extracting volatile oil from Zingiberis rhizoma and herba asari respectively, and clathrating the volatile oil with beta-cyclodextrin to obtain clathrate and collecting the residue;
(2) decocting the dregs, notopterygium root and perilla leaf in water for 2 times, each time for 2 hours, combining the water decoction, filtering, concentrating the filtrate, adding ethanol into the concentrated solution to ensure that the ethanol content reaches 60%, precipitating with ethanol, refrigerating for 24 hours, filtering, recovering the ethanol from the filtrate, and concentrating to obtain a concentrated solution I with the relative density of 1.22-1.23 at the temperature of 60 ℃;
(3) decocting herba schizonepetae, angelica dahurica, platycodon grandiflorum, fermented soya beans, ephedra, centipeda minima, cassia twig, divaricate saposhnikovia root, honey-fried licorice root, blackberrykiky rhizome, almond, radix bupleuri, agastache rugosus, gypsum, heartleaf houttuynia herb, fortune eupatorium herb and poria cocos with water for 2 times, each time for 2 hours, combining water decoction, adding 60% ethanol for extraction twice, extracting for 2 hours for the first time and 1 hour for the second time, combining extracting solutions, filtering, recovering ethanol from filtrate, and concentrating into a second concentrated solution with the relative density of 1.21-1.22;
(4) pulverizing the dried ginger volatile oil inclusion and the asarum volatile oil inclusion obtained in the step (1) into fine powder, sieving and uniformly mixing; mixing the first concentrated solution and the second concentrated solution, adding the above fine powder, adding starch, dextrin, microcrystalline cellulose, magnesium stearate, lactose, Mel, xylooligosaccharide, and antiseptic, and making into granule.
The refrigerating temperature in the step (2) is-2 to 2 ℃.
In the selected raw material traditional Chinese medicinal materials, the drug effect and the pharmacological action are respectively as follows:
herba schizonepetae: pungent, slightly bitter and slightly warm in nature; enter lung and liver meridians. The efficacy is mainly as follows: expelling wind, relieving exterior syndrome, promoting eruption, and stopping bleeding. It is mainly used for treating common cold, fever, headache, eye itching, cough, swelling and pain of throat, measles, carbuncle, scabies, epistaxis, hematemesis, hematochezia, metrorrhagia, and puerperal dizziness. Schizonepeta has strong fragrance, and fresh and tender stem and leaf are mainly used as vegetable for eating.
Prepared licorice root, radix Glycyrrhizae Praeparata has the effects of nourishing yin and blood, tonifying qi and activating yang, and recovering pulse and stopping palpitation.
Dried ginger: pungent taste and mild nature; it enters lung, spleen and stomach meridians. The efficacy is as follows: relieving exterior syndrome, dispelling cold, warming middle energizer, relieving vomiting, warming lung, relieving cough, and removing toxic substance; the main treatment is as follows: wind-cold type common cold, spleen and stomach cold syndrome, stomach cold vomiting, cough due to lung cold, and fish and crab toxin relieving effect.
Wind prevention: pungent and sweet in flavor and slightly warm in nature; it enters bladder, lung, spleen and liver meridians. Has effects of dispelling pathogenic wind, relieving exterior syndrome, eliminating dampness, relieving pain, and relieving spasm; the main treatment is as follows: can be used for treating exterior syndrome due to exogenous pathogenic factor, rubella pruritus, rheumatalgia, tetanus, and spleen deficiency with excessive dampness.
Radix Angelicae Dahuricae has effects of relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, relieving pain, dredging nasal orifice, eliminating dampness, relieving leukorrhagia, relieving swelling, expelling pus, dispelling pathogenic wind and relieving itching. It can be used for treating wind-cold type common cold, headache, toothache, rheumatalgia, nasosinusitis, leukorrhagia, sore, carbuncle, and toxic swelling.
Herba ephedrae: is a herbal medicine recorded in Chinese pharmacopoeia, and the medicinal source is dry herbaceous stems of Ephedra sinica, Ephedra sinica or Ephedra equiseti, which are Ephedra sinica Maxim, green herbaceous stems are harvested in autumn and dried in the sun. The efficacy is as follows: induce sweating and dispel cold, ventilate lung and relieve dyspnea, induce diuresis to alleviate edema.
Perilla leaf: pungent, mild and non-toxic; it enters spleen and lung meridians. The aromatic ascending powder has the effects of dispelling cold, relieving exterior syndrome, dispersing lung qi, relieving cough, regulating qi, regulating the middle warmer, preventing miscarriage and detoxifying; can be used for treating wind cold, fever, headache, no sweat, cough, asthma, abdominal distention, emesis, diarrhea, obstruction of pharynx, pernicious vomiting, threatened abortion, fish and crab poisoning, carbuncle, sore, and snake poison and peppery taste. The folium Perillae contains fructus Perillae as nutritional component, and has effects of relieving cough and asthma, and resolving phlegm.
Platycodon grandiflorum, radix Platycodonis, lung ventilating, sore throat relieving, phlegm eliminating, and pus discharging. Can be used for treating cough with excessive phlegm, chest distress, pharyngalgia, hoarseness, lung carbuncle, suppuration, and pyocutaneous disease with pus formation.
Notopterygii rhizoma enters bladder and kidney meridians. Has the effects of relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, eliminating dampness, and relieving pain. It can be used for treating wind-cold type common cold, arthralgia due to wind-cold-dampness, neck stiffness, spasm of muscles, soreness of bone joints, edema due to wind-damp, superficial infection, and skin sore.
Fermented soya beans have mild nature and salty taste, and enter lung and stomach meridians. Has effects in regulating stomach function, relieving vexation, removing fishy smell, and removing cold and heat.
Gui Zhi is pungent, sweet and warm. It enters heart, lung and bladder meridians. Has effects of inducing sweat, expelling pathogenic factors from muscles, warming and dredging channels, supporting yang, regulating qi, and lowering qi. It is commonly used for wind-cold type common cold, abdominal cold pain, amenorrhea due to blood cold, arthralgia, phlegm and fluid retention, edema and palpitation.
The centipeda minima has the effects of dispersing wind cold, relieving stuffy nose, relieving cough and detoxifying. It can be used for treating wind-cold type common cold, nasal obstruction, cough with asthma due to cold-phlegm, sore, carbuncle, and toxic swelling.
Rhizoma Belamcandae is bitter in taste, cold in nature and slightly toxic. Has effects in clearing away heat and toxic materials, dispersing pathogen accumulation, relieving inflammation, swelling and pain, relieving cough, and eliminating phlegm, and can be used for treating tonsillitis and lumbago.
The asarum has the effects of expelling wind, dispelling cold, promoting diuresis, inducing resuscitation and the like. It is commonly used for wind-cold headache, nasosinusitis, toothache, phlegm-fluid cough, wind-damp arthralgia, etc. The asarum can not only externally disperse wind-cold but also internally dispel yin-cold, and has better effects of relieving pain and cough.
The almond has good medicinal value, such as relieving cough and asthma, enhancing human immunity, delaying senility, regulating blood fat, nourishing brain, benefiting intelligence, and the like. The content of amygdalin with various pharmacological actions in the bitter almond reaches 5.5 percent, and the modern medicine considers that the amygdalin has the action of inhibiting and killing cancer cells. The almond is widely applied to the fields of food, cosmetics, medicines and the like.
Bupleurum root, radix bupleuri is a commonly used exterior syndrome relieving drug. Is also called as Diwu, potherb mustard, mushroom grass and firewood, is bitter in nature and taste, slightly cold, and enters liver and gallbladder meridians. Has the functions of harmonizing exterior and interior, soothing liver and invigorating yang. Can be used for treating common cold, fever, malaria, stagnation of qi due to depression of the liver, distending pain of chest and hypochondrium, rectocele, uterine prolapse, and menoxenia.
Agastache rugosus enters spleen, stomach and lung meridians. Resolve dampness and enliven the spleen, avoid dirty and harmonize the middle energizer, relieve summer-heat and release exterior. Can be used for treating syndrome of dampness obstruction of spleen and stomach, abdominal distention, early stage of damp-warm syndrome, emesis, diarrhea, summer-heat dampness, fever with aversion to cold, and chest and abdominal fullness.
The plaster stone is mainly used for treating apoplexy with chills and fever, and has the functions of relieving muscles and sweating, removing dry mouth and tongue scorch, relieving headache and toothache, and the like.
Yu xing Cao is pungent in flavor and cold in nature and enters lung meridian. It has effects of clearing away heat and toxic materials, relieving swelling, treating sore, inducing diuresis, removing dampness, clearing away heat, relieving dysentery, invigorating stomach, and resolving food stagnation, and can be used for treating lung abscess, pyocutaneous disease, hemorrhoid hematochezia, and heat accumulation of spleen and stomach due to excess heat, heat toxin, dampness, and disease heat. Modern pharmacological experiments show that the product has antibacterial, antiviral, immunity improving, and diuretic effects.
The eupatorium fortunei is neutral in nature, pungent in taste, capable of promoting diuresis, invigorating stomach and clearing summer-heat. Headache due to summer-heat and dampness; internal retention of moisture; epigastric fullness without hunger; nausea and vomiting; sweet and greasy in mouth; the query is resolved. Can be used for treating damp stagnation, gastric fullness, emesis, halitosis, sialorrhea, summer-heat dampness, headache, and chest distress.
Poria cocos wolf enters heart, lung, spleen and kidney meridians. Induce diuresis and drain dampness, invigorate spleen and calm heart. Can be used for treating edema, oliguria, phlegm and fluid retention, dizziness, palpitation, spleen deficiency, anorexia, loose stool, diarrhea, uneasiness, palpitation, and insomnia.
The invention has the advantages that: the traditional Chinese medicine electuary for treating wind-cold type common cold is prepared by scientifically combining traditional Chinese medicine raw materials which are used as both medicine and food, has no toxic or side effect, is safe and reliable, can effectively treat wind-cold type common cold, has the effects of relieving exterior syndrome and dispelling cold, ventilating and smoothing lung with acrid substance, and relieving pain, is short in treatment course, quick in effect, safe, effective, low in price, convenient to use, and can obtain better economic and social benefits after popularization and application.
Detailed Description
A traditional Chinese medicine electuary for treating common cold due to wind-cold is prepared from the following raw material medicines in parts by weight:
7 parts of schizonepeta, 6 parts of honey-fried licorice root, 2 parts of dried ginger, 7 parts of divaricate saposhnikovia root, 7 parts of angelica dahurica, 8 parts of platycodon grandiflorum, 7 parts of notopterygium root, 8 parts of fermented soya beans, 7 parts of ephedra, 10 parts of perilla leaf, 8 parts of cassia twig, 7 parts of centipeda minima, 12 parts of blackberry lily, 3 parts of asarum, 9 parts of almond, 10 parts of radix bupleuri, 3 parts of agastache rugosus, 9 parts of gypsum, 9 parts of houttuynia cordata, 7 parts of eupatorium and 12 parts of poria cocos.
A preparation method of traditional Chinese medicine electuary for treating common cold due to wind-cold comprises the following specific steps:
(1) extracting volatile oil from Zingiberis rhizoma and herba asari respectively, and clathrating the volatile oil with beta-cyclodextrin to obtain clathrate and collecting the residue;
(2) decocting the residue, Notopterygii rhizoma and folium Perillae in water for 2 times, each for 2 hr, mixing decoctions, filtering, concentrating the filtrate, adding ethanol into the concentrated solution to make the ethanol content reach 60%, precipitating with ethanol, refrigerating for 24 hr, filtering, recovering ethanol from the filtrate, and concentrating to obtain first concentrated solution with relative density of 1.22 at 60 deg.C;
(3) decocting herba Schizonepetae, radix Angelicae Dahuricae, radix Platycodi, semen Sojae Preparatum, herba Ephedrae, herba Centipedae, ramulus Cinnamomi, radix Saposhnikoviae, radix Glycyrrhizae Preparata, rhizoma Belamcandae, semen Armeniacae amarum, bupleuri radix, herba Agastaches, Gypsum Fibrosum, herba Houttuyniae, herba Eupatorii, and Poria with water for 2 times, each time for 2 hr, mixing decoctions, extracting with 60% ethanol twice, the first time for 2 hr and the second time for 1 hr, mixing extractive solutions, filtering, recovering ethanol from the filtrate, and concentrating to obtain second concentrated solution with relative density of 1.21;
(4) pulverizing the dried ginger volatile oil inclusion and the asarum volatile oil inclusion obtained in the step (1) into fine powder, sieving and uniformly mixing; mixing the first concentrated solution and the second concentrated solution, adding the above fine powder, adding starch, dextrin, microcrystalline cellulose, magnesium stearate, lactose, Mel, xylooligosaccharide, and antiseptic, and making into granule.
The refrigeration temperature in the step (2) is-2 ℃.
A typical case one: in the case of a certain prescription, men, 33 years old, office workers, have self-reported symptoms of general aching pain, nasal obstruction, watery nasal discharge, cough with phlegm and sneezing. The medicine of the embodiment is used for treating 3 times a day, 1 bag is taken each time, the ache is relieved after one day, the sneezing symptom disappears, the nasal obstruction and the nasal discharge symptom are obviously improved after three days of treatment, and the symptom completely disappears after one week of treatment.
Typical case 2: in Li, a woman is 45 years old, and the driver states that the symptoms are fever, chills, nasal obstruction, thin nasal discharge, cough, thin and white sputum, headache, general aching pain and anorexia. Using the drug of this example for treatment, 3 times a day, 1 bag each time, after 2 days of treatment, symptoms began to decrease; after 3 days of treatment, the symptoms are obviously improved, and after 8 days of treatment, the symptoms are completely disappeared.
Typical case 3: zhangyi, female, age 65, retired worker, self-reported symptoms of general weakness, nasal obstruction, running nose, headache, normal appetite, expectoration, dry and painful throat, using the drug of this example to treat 3 times a day, 1 bag each time, 1 day after treatment, the symptoms begin to alleviate; after 3 days of treatment, the symptoms all disappeared.

Claims (4)

1. A traditional Chinese medicine electuary for treating common cold due to wind-cold is characterized in that: the traditional Chinese medicine electuary is prepared from the following raw material medicines in parts by weight:
3-9 parts of schizonepeta, 6-8 parts of honey-fried licorice root, 2-3 parts of dried ginger, 3-9 parts of divaricate saposhnikovia root, 3-9 parts of dahurian angelica root, 5-10 parts of platycodon root, 3-9 parts of notopterygium root, 3-10 parts of fermented soya beans, 3-9 parts of ephedra herb, 8-11 parts of perilla leaf, 6-10 parts of cassia twig, 3-9 parts of centipeda minima, 10-14 parts of blackberry lily, 2-4 parts of asarum, 6-12 parts of almond, 8-12 parts of radix bupleuri, 3-4 parts of wrinkled gianthyssop herb, 8-10 parts of gypsum, 6-15 parts of houttuynia cordata, 3-9 parts of fortune eupatorium herb and 10-12 parts of poria cocos.
2. The traditional Chinese medicine electuary for treating wind-cold type common cold according to claim 1, which is characterized in that: the traditional Chinese medicine electuary is prepared from the following raw material medicines in parts by weight:
7 parts of schizonepeta, 6 parts of honey-fried licorice root, 2 parts of dried ginger, 7 parts of divaricate saposhnikovia root, 7 parts of angelica dahurica, 8 parts of platycodon grandiflorum, 7 parts of notopterygium root, 8 parts of fermented soya beans, 7 parts of ephedra, 10 parts of perilla leaf, 8 parts of cassia twig, 7 parts of centipeda minima, 12 parts of blackberry lily, 3 parts of asarum, 9 parts of almond, 10 parts of radix bupleuri, 3 parts of agastache rugosus, 9 parts of gypsum, 9 parts of houttuynia cordata, 7 parts of eupatorium and 12 parts of poria cocos.
3. A preparation method of traditional Chinese medicine electuary for treating common cold due to wind-cold is characterized by comprising the following steps: the method comprises the following specific steps:
(1) extracting volatile oil from Zingiberis rhizoma and herba asari respectively, and clathrating the volatile oil with beta-cyclodextrin to obtain clathrate and collecting the residue;
(2) decocting the dregs, notopterygium root and perilla leaf in water for 2 times, each time for 2 hours, combining the water decoction, filtering, concentrating the filtrate, adding ethanol into the concentrated solution to ensure that the ethanol content reaches 60%, precipitating with ethanol, refrigerating for 24 hours, filtering, recovering the ethanol from the filtrate, and concentrating to obtain a concentrated solution I with the relative density of 1.22-1.23 at the temperature of 60 ℃;
(3) decocting herba schizonepetae, angelica dahurica, platycodon grandiflorum, fermented soya beans, ephedra, centipeda minima, cassia twig, divaricate saposhnikovia root, honey-fried licorice root, blackberrykiky rhizome, almond, radix bupleuri, agastache rugosus, gypsum, heartleaf houttuynia herb, fortune eupatorium herb and poria cocos with water for 2 times, each time for 2 hours, combining water decoction, adding 60% ethanol for extraction twice, extracting for 2 hours for the first time and 1 hour for the second time, combining extracting solutions, filtering, recovering ethanol from filtrate, and concentrating into a second concentrated solution with the relative density of 1.21-1.22;
(4) pulverizing the dried ginger volatile oil inclusion and the asarum volatile oil inclusion obtained in the step (1) into fine powder, sieving and uniformly mixing; mixing the first concentrated solution and the second concentrated solution, adding the above fine powder, adding starch, dextrin, microcrystalline cellulose, magnesium stearate, lactose, Mel, xylooligosaccharide, and antiseptic, and making into granule.
4. The preparation method of the traditional Chinese medicine electuary for treating wind-cold type common cold according to claim 1, is characterized in that: the refrigerating temperature in the step (2) is-2 to 2 ℃.
CN202110666456.1A 2021-06-16 2021-06-16 Traditional Chinese medicine electuary for treating wind-cold type common cold and preparation method thereof Withdrawn CN113230377A (en)

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