CN1149093C - Medicine for treating female acyesis - Google Patents

Abstract

The present invention discloses a medicine for treating female acyesis, which is prepared from the component raw materials of 40 Chinese medicinal plants, such as broomrape, glossy privet fruit, medicinal indianmulberry root, forsythia fruit, pilose asiabell root, Chinese angelica, etc. The medicine can be prepared into the preparation forms of decoction, soft extract, tablets, honeyed pills, watered pills, capsules, granular granules, oral liquid, condensed pills, etc. by a usually used modern technological method in pharmacy. The medicine has a good effect on treating female acyesis caused by adnexitis, pelvic inflammation, hydrosalpinx, oophoritic cyst, mycoplasma infection, chlamydia infection, etc.

Description

A kind of medicine for the treatment of infertility

The present invention relates to be used for the treatment of the pharmaceutical composition of infertility, specifically is the Chinese patent medicine of feedstock production with Chinese herbal medicine.

Infertility is important medical of world wide and social problem.Its prevalence generally accounts for the couple at child-bearing age's 5%～15%.Investigate according to WHO (World Health Organization) nineteen ninety, U.S.'s infertility prevalence is 14.3%, and Finland is 15.4%, and the Gabon in Africa is then up to 32%.China is according to some odd investigation, and the infertility prevalence is lower, below 5%.But because Chinese population is many, the patients with infertility absolute number is still very big.And China classifies family planning as fundamental state policy, is the ingredient of family planning work to the treatment of infertility, and therefore particular importance is arranged.

According to statistics, in infertility, what belong to wife's side reason accounts for 60%.In infertility, absolute infertile person is an only a few; And can conceptive infertile relatively person be in the great majority through treatment, its reason has inflammation, cyst, female incretion deficiency etc.The medicine of various treatment infertility is at the relative infertility of this back one class.Yet the medicine for the treatment of infertility at present remains the dissatisfied part all people of making.If any the pathophorous medicine of therapeutic when curing sexually transmitted disease (STD), can eliminate the infertile reason of some patient, but not strong as its specific aim of medicine of treatment infertility; The medicine that has only works to the inflammation that certain pathogen causes, the indication narrow range; The medicine that has is specifically designed to some links of improving female incretion, more can not be as the fertility drug of widespread usage.

The traditional Chinese medical herbal treatment infertility has its special advantages.I study infertility according to the theoretical system of motherland's medical science for many years, press the theoretical prescription of tcm treatment according to syndrome differentiation, pharmacy, am obtaining the mature technology achievement that comprises the present invention aspect the treatment infertility.

The objective of the invention is to, provide a kind of to extensive Chinese medicine preparation that is suitable for of treatment infertility and its Chinese patent medicine dosage form, its determined curative effect is reliable, and has no side effect, and is safe and convenient to use.

Press tcm theory, infertilitas feminis is many to suffer from a deficiency of the kidney, damage of essence insufficiency of blood, uterus deficiency and coldness, to dash and appoint due to the deficiency.The present invention be based on motherland's medical science to the understanding of infertility with to the understanding of the multiple Chinese herbal medicine property of medicine, by types of drugs compatibility and corresponding processing of medical material processing method, make the present invention have excellent function.

The component of medicine of the present invention comprises following crude drug kind, and the consumption of each crude drug is expressed as follows with weight portion.

Radix Codonopsis 9-24 Radix Astragali 9-30 Radix Rehmanniae 8-24 Radix Rehmanniae Preparata 8-24

Radix Angelicae Sinensis 9-18 Radix Paeoniae Alba 12-30 Rhizoma Chuanxiong 4-12 Rhizoma Atractylodis Macrocephalae 5-18

Poria 8-21 Radix Glycyrrhizae 2-15 Rhizoma Polygoni Cuspidati 9-35 Radix Ophiopogonis 3-18

Rhizoma Smilacis Glabrae 9-36 Radix Bupleuri 4-25 Concha Ostreae 12-40 Fructus Gardeniae 4.5-15

Cortex Moutan 5-18 flower 3-15 Herba Houttuyniae 12-31 Flos Lonicerae 6-24

Fructus Forsythiae 8-26 Herba Taraxaci 12-36 Herba Violae 12-33 Rhizoma Corydalis 5-18

Fructus Toosendan 7-21 Rhizoma Pinelliae Preparata 3-12 Semen Cuscutae 7-24 Fructus Rubi 6-18

Fructus Lycii 7-24 Fructus Schisandrae Chinensis 6-19 Semen Plantaginis 3-21 Cornu Cervi Pantotrichum 0.2-1.8

Radix Morindae Officinalis 5-28 Herba Cistanches 6-22 Fructus Ligustri Lucidi 7-27 Placenta Hominis 1.5-6

Fructus Psoraleae 7-24 Radix Achyranthis Bidentatae 8-32 Rhizoma Drynariae 8-20 Semen Litchi 4-21

Preferred version is,

Radix Codonopsis 9-12 Radix Astragali 12-16 Radix Rehmanniae 12-16 Radix Rehmanniae Preparata 12-16

Radix Angelicae Sinensis 10-12 Radix Paeoniae Alba 14-16 Rhizoma Chuanxiong 7-8 Rhizoma Atractylodis Macrocephalae 8-10

Poria 13-16 Radix Glycyrrhizae 3-6 Rhizoma Polygoni Cuspidati 18-23 Radix Ophiopogonis 8-11

Rhizoma Smilacis Glabrae 17-22 Radix Bupleuri 6-9 Concha Ostreae 18-21 Fructus Gardeniae 5-7

Cortex Moutan 5-8 flower 4-8 Herba Houttuyniae 18-22 Flos Lonicerae 8-11

Fructus Forsythiae 10-13 Herba Taraxaci 18-22 Herba Violae 17-19 Rhizoma Corydalis 8-10

Fructus Toosendan 8-11 Rhizoma Pinelliae Preparata 5-7 Semen Cuscutae 11-14 Fructus Rubi 10-14

Fructus Lycii 10-13 Fructus Schisandrae Chinensis 10-14 Semen Plantaginis 5-8 Cornu Cervi Pantotrichum 0.7-1.2

Radix Morindae Officinalis 10-14 Herba Cistanches 13-17 Fructus Ligustri Lucidi 14-18 Placenta Hominis 2-4

Fructus Psoraleae 10-14 Radix Achyranthis Bidentatae 10-14 Rhizoma Drynariae 12-17 Semen Litchi 8-12

Optimum proportion scheme is,

Radix Codonopsis 12 Radixs Astragali 15 Radix Rehmanniae 15 Radix Rehmanniaes Preparata 15 Radix Angelicae Sinensis 10 Radix Paeoniae Albas 15

Rhizoma Chuanxiong 8 Rhizoma Atractylodis Macrocephalaes 9 Poria 15 Radix Glycyrrhizaes 4 Rhizoma Polygoni Cuspidati 21 Radix Ophiopogonis 10

Rhizoma Smilacis Glabrae 20 Radix Bupleuri 8 Concha Ostreae 20 Fructus Gardeniaes 6 Cortex Moutans 7 Flos Carthamis 6

Herba Houttuyniae 21 Flos Loniceraes 10 Fructus Forsythiaes 12 Herba Taraxacis 20 Herba Violaes 18 Rhizoma Corydalis 9

Fructus Toosendan 10 Rhizoma Pinelliae Preparata 6 Semen Cuscutae 12 Fructus Rubies 12 Fructus Lycii 10 Fructus Schisandrae Chinensis 10

Semen Plantaginis 7 Cornu Cervi Pantotrichums 0.8 Radix Morindae Officinalis 12 Herba Cistanches 15 Fructus Ligustri Lucidi 16 Placenta Hominiss 3

Fructus Psoraleae 12 Radix Achyranthis Bidentataes 12 Rhizoma Drynariae 15 Semen Litchis 9

The part medicine should be concocted the back use in the above-mentioned raw materials medicine: 1. the Rhizoma Atractylodis Macrocephalae is made parched with bran or parching with earth; 2. Fructus Gardeniae does general parch; 3. Rhizoma Corydalis is done the vinegar stir-fry, also can not add parch, uses its crude drug; 4. Fructus Psoraleae is done the saline stir-fry.

Above crude drug can be manufactured dosage forms such as decoct, soft extract, tablet, honeyed pill, the watered pill, capsule, granular pattern electuary, oral liquid, concentrated pill by normally used pharmaceutical technique method of modern times.Preferably concentrated pill and water pill.

More than various dosage forms oral dose on the one be equivalent to crude drug 400-520 gram approximately, divide and take for 2-4 time.Generally began to take in the 5th day from menstruation, logotype 12-15 days is a course of treatment.When being main purpose with the treatment inflammation, can continuous use, only drug withdrawal in a few days of menstrual onset.

In the drug component of the present invention, the salty temperature of Herba Cistanches, the kidney invigorating gas benefit marrow, tonifying Chong and Ren channels cooperates all medicines gravidity assisting effect of promoting the sexual maturity, and is to be principal agent; The Radix Codonopsis sweet in the mouth is flat, and the tonifying the lung strengthening the spleen cooperates his medicine to separate women's blood deficiency and blood stasis; Medicine heat-clearing and toxic substances removing such as Fructus Forsythiae, dispersing swelling and dissipating binds has certain curative effect to ovarian cyst, active chronic inflammation, to assist all medicines; The Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.Say that in some sense pharmaceutical formulation of the present invention is a Comprehensive Treatment side.At female infertility patients usually is being on the state of an illness in all pathological changes such as inflammation (adnexitis and pelvic inflammatory disease), inflammatory mass, hydrosalpinx, ovarian cyst, endometriosis, tuberculosis, hysteromyoma, uterine hypoplasia, cryptorrhea, the situation that has two or more pathological changes simultaneously, the present invention extensively is suitable for.

The inventor uses Drug therapy female infertility patients 3000 many cases of the present invention, comprises cases such as adnexitis, pelvic inflammatory disease, hydrosalpinx, ovarian cyst, mycoplasma, chlamydia infection, obtains good result.Wherein through B ultrasonic diagnosis and make ovarian cyst case 50 many cases of tracing study, through take medicine of the present invention after 1～3 course of treatment cyst disappear substantially.Again 105 examples are used B ultrasonic and do in the course of treatment follicular development and observe, the normal person of all menstrual cycle generally germinates in 5～9 days follicles of taking medicine, and diameter can occur course of treatment and reach dominant follicle more than 2.0 centimeters.First of medication moon 71 examples (67.6%) of becoming pregnant, medication accumulative total 91 examples (86.6%) of becoming pregnant in the second month.

The invention will be further described by the following examples.

Embodiment 1～4

According to the form below institute number of columns takes by weighing each crude drug respectively.Unit of weight is " kilogram ".

Listed each the embodiment dose of last table is 1000 people's feed rations.Be the one thousandth that everyone consumption every day is equivalent to each embodiment manufactured goods, divide 2～4 times oral.

Embodiment 1 produces soft extract, and its method is, the Rhizoma Atractylodis Macrocephalae is made parching with earth, and Fructus Gardeniae does general parch, and Rhizoma Corydalis is made vinegar and fried, and Fructus Psoraleae is made saline and fried.The solid medical material of Part Traits is pulverized a little.Each medical material is mixed, decoct with water 3 times, each boiling 2～3 hours, collecting decoction filters, and leaves standstill 24 hours, get supernatant concentration to clear paste than weigh 1.21～1.25 (80～85 ℃ of surveys), add the red pool 200 grams (add and propagandize sugar hotly to fusing) by 100 gram clear paste, mixing is evaporated to following proportion: get cream 10 grams and add that its proportion is 1.10～1.12 after 20 milliliters of dilutions of water.

Embodiment 2 produces oral liquid, and its method is, the Rhizoma Atractylodis Macrocephalae is made parched with bran, and Fructus Gardeniae does general parch, and Rhizoma Corydalis is made vinegar and fried, and Fructus Psoraleae is made saline and fried.Each medical material is mixed, decoct with water 3 times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, collecting decoction filtered, and filtrate is concentrated into about 100 liters, put coldly, add 150 liters of ethanol, stir, left standstill 24 hours, filter, filtrate decompression is concentrated into the extractum shape, with the suitable quantity of water dilution, filters, add 30 liters of simple syrups, sodium benzoate 300 grams, add water to 160 liters again, cold preservation, filter, be packaged in 20 milliliters of ampoule glass bottles, sterilize 30 minutes promptly with 100 ℃.During use everyone each oral 40 milliliters, every day 4 times.

Embodiment 3 produces the watered pill, and its method is that the Rhizoma Atractylodis Macrocephalae is made parching with earth; Fructus Gardeniae does general parch; Fructus Psoraleae is made saline and is fried.Radix Rehmanniae Preparata, Fructus Lycii, Concha Ostreae are decocted 3 times, and each 2 hours, collecting decoction filtered, and gets filtrate for later use.All the other medical material pulverize separately are crossed 100 mesh sieves, get the medicated powder mix homogeneously.With decoction liquor and medicated powder molding and the general piller of making, cold drying promptly after screening.

Embodiment 4 produces concentrated watered pill, and its method is that the process of preparing Chinese medicine of part medical material is with embodiment 3.With the Radix Rehmanniae, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Poria, Rhizoma Polygoni Cuspidati, Rhizoma Smilacis Glabrae, Concha Ostreae, Herba Houttuyniae, Herba Taraxaci, Herba Violae, Fructus Lycii, Radix Morindae Officinalis, Fructus Ligustri Lucidi, Fructus Psoraleae, Rhizoma Drynariae totally 16 kinds of medical materials decoct 3 times, each 2 hours, collecting decoction filters, and gets filtrate for later use.All the other medical material pulverize separately are crossed 100 mesh sieves, get the medicated powder mix homogeneously.With decoction liquor and medicated powder molding and the general piller of making, cold drying promptly after screening.

Claims (4)

1. a medicine for the treatment of infertility is characterized in that, it is the medicament of being made by the following weight proportion raw material,

Radix Codonopsis 9-24 Radix Astragali 9-30 Radix Rehmanniae 8-24 Radix Rehmanniae Preparata 8-24

Radix Angelicae Sinensis 9-18 Radix Paeoniae Alba 12-30 Rhizoma Chuanxiong 4-12 Rhizoma Atractylodis Macrocephalae 5-18

Poria 8-21 Radix Glycyrrhizae 2-15 Rhizoma Polygoni Cuspidati 9-35 Radix Ophiopogonis 3-18

Rhizoma Smilacis Glabrae 9-36 Radix Bupleuri 4-25 Concha Ostreae 12-40 Fructus Gardeniae 4.5-15

Cortex Moutan 5-18 Flos Carthami 3-15 Herba Houttuyniae 12-31 Flos Lonicerae 6-24

Fructus Forsythiae 8-26 Herba Taraxaci 12-36 Herba Violae 12-33 Rhizoma Corydalis 5-18

Fructus Toosendan 7-21 Rhizoma Pinelliae Preparata 3-12 Semen Cuscutae 7-24 Fructus Rubi 6-18

Fructus Lycii 7-24 Fructus Schisandrae Chinensis 6-19 Semen Plantaginis 3-21 Cornu Cervi Pantotrichum 0.2-1.8

Radix Morindae Officinalis 5-28 Herba Cistanches 6-22 Fructus Ligustri Lucidi 7-27 Placenta Hominis 1.5-6

Fructus Psoraleae 7-24 Radix Achyranthis Bidentatae 8-32 Rhizoma Drynariae 8-20 Semen Litchi 4-21.

2. medicine according to claim 1, the weight proportion of each crude drug be,

Radix Codonopsis 9-12 Radix Astragali 12-16 Radix Rehmanniae 12-16 Radix Rehmanniae Preparata 12-16

Radix Angelicae Sinensis 10-12 Radix Paeoniae Alba 14-16 Rhizoma Chuanxiong 7-8 Rhizoma Atractylodis Macrocephalae 8-10

Poria 13-16 Radix Glycyrrhizae 3-6 Rhizoma Polygoni Cuspidati 18-23 Radix Ophiopogonis 8-11

Rhizoma Smilacis Glabrae 17-22 Radix Bupleuri 6-9 Concha Ostreae 18-21 Fructus Gardeniae 5-7

Cortex Moutan 5-8 flower 4-8 Herba Houttuyniae 18-22 Flos Lonicerae 8-11

Fructus Forsythiae 10-13 Herba Taraxaci 18-22 Herba Violae 17-19 Rhizoma Corydalis 8-10

Fructus Toosendan 8-11 Rhizoma Pinelliae Preparata 5-7 Semen Cuscutae 11-14 Fructus Rubi 10-14

Fructus Lycii 10-13 Fructus Schisandrae Chinensis 10-14 Semen Plantaginis 5-8 Cornu Cervi Pantotrichum 0.7-1.2

Radix Morindae Officinalis 10-14 Herba Cistanches 13-17 Fructus Ligustri Lucidi 14-18 Placenta Hominis 2-4

Fructus Psoraleae 10-14 Radix Achyranthis Bidentatae 10-14 Rhizoma Drynariae 12-17 Semen Litchi 8-12.

3. medicine according to claim 1, the weight proportion of each crude drug be,

Radix Codonopsis 12 Radixs Astragali 15 Radix Rehmanniae 15 Radix Rehmanniaes Preparata 15 Radix Angelicae Sinensis 10 Radix Paeoniae Albas 15

Rhizoma Chuanxiong 8 Rhizoma Atractylodis Macrocephalaes 9 Poria 15 Radix Glycyrrhizaes 4 Rhizoma Polygoni Cuspidati 21 Radix Ophiopogonis 10

Rhizoma Smilacis Glabrae 20 Radix Bupleuri 8 Concha Ostreae 20 Fructus Gardeniaes 6 Cortex Moutans 7 Flos Carthamis 6

Herba Houttuyniae 21 Flos Loniceraes 10 Fructus Forsythiaes 12 Herba Taraxacis 20 Herba Violaes 18 Rhizoma Corydalis 9

Fructus Toosendan 10 Rhizoma Pinelliae Preparata 6 Semen Cuscutae 12 Fructus Rubies 12 Fructus Lycii 10 Fructus Schisandrae Chinensis 10

Semen Plantaginis 7 Cornu Cervi Pantotrichums 0.8 Radix Morindae Officinalis 12 Herba Cistanches 15 Fructus Ligustri Lucidi 16 Placenta Hominiss 3

Fructus Psoraleae 12 Radix Achyranthis Bidentataes 12 Rhizoma Drynariae 15 Semen Litchis 9.

4. according to claim 1,2 or 3 described medicines, it is characterized in that said medicament is the concentrated watered pill or the watered pill.