CN102343019A - Chinese medicinal composition for treating amenorrhea and preparation method of preparation thereof - Google Patents

Chinese medicinal composition for treating amenorrhea and preparation method of preparation thereof Download PDF

Info

Publication number
CN102343019A
CN102343019A CN2011103125630A CN201110312563A CN102343019A CN 102343019 A CN102343019 A CN 102343019A CN 2011103125630 A CN2011103125630 A CN 2011103125630A CN 201110312563 A CN201110312563 A CN 201110312563A CN 102343019 A CN102343019 A CN 102343019A
Authority
CN
China
Prior art keywords
parts
amenorrhea
radix
preparation
blood
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN2011103125630A
Other languages
Chinese (zh)
Other versions
CN102343019B (en
Inventor
孙丰卿
成林
于春阳
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nantong San Intellectual Property Service Co ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN2011103125630A priority Critical patent/CN102343019B/en
Publication of CN102343019A publication Critical patent/CN102343019A/en
Application granted granted Critical
Publication of CN102343019B publication Critical patent/CN102343019B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Landscapes

  • Medicines Containing Plant Substances (AREA)

Abstract

The invention relates to a Chinese medicinal composition for treating amenorrhea and a preparation method of a preparation thereof. The Chinese medicinal composition comprises the following raw materials in parts by weight: 5-15 parts of ground beetle, 15-25 parts of red paeony root, 15-25 parts of Chinese angelica, 5-15 parts of szechuan lovage rhizome, 10-20 parts of safflower, 15-25 parts of nutgrass galingale rhizome, 10-20 parts of trogopterus dung, 5-15 parts of green tangerine peel, 15-25 parts of prepared rehmannia rhizome, 5-15 parts of peach kernel, 25-35 parts of motherwort herb and 15-25 parts of medicinal cyathula root. The invention further provides a preparation method of a decoction, paste, capsules, tablets, granules, water pills, honeyed pills or enteric coated tablets of the traditional Chinese medicine. The Chinese medicinal composition is applied internally and externally, has the effects of treating both principal and secondary aspects of a disease, can be used for inducing treatment of endometrial thickening during menstruation and facilitating falling of a thickened endometrium, has good curative effects on amenorrhea and hypomenorrhea, has low raw material price, and has the characteristics of small dosage, quick response and small side effect.

Description

A kind of method for preparing that is used to treat the Chinese medicine composition and the preparation thereof of amenorrhea
Technical field
The present invention relates to a kind of method for preparing that is used to treat the Chinese medicine composition and the preparation thereof of amenorrhea, belong to tcm field.
Background technology
Amenorrhea is a kind of common sympton of gynaecopathia, is not single disease.The reason of amenorrhea has: uterine amenorrhea--congenital vagina and (or) defectus uteri or dysplasia all can cause primary amenorrhea.Over-drastic dilatation and curettage or serious infection such as tuberculosis etc. cause inner film injury or adhesion, and time of nursing is long to make atrophy of endometrium etc., all can cause the amenorrhea of supervention property.Ovarian amenorrhea--the amenorrhea that causes because of oophoropathy.Secondary amenorrhea can be because of behind premature ovarian failure, excision, the radiotherapy and the manlike tumor of ovary etc.The pituitary amenorrhea--occur in prepuberal pituitary tumor and can cause primary amenorrhea.Hypothalamic amenorrhea--hypothalamus is controlled by the central nervous system, and excessively psychentonia, worry, fear, living environment change, and all can cause central nervous system and hypothalamus functional disorder, amenorrhea occurs.Young woman particularly.Ovarian function is still unsound, more is prone to disorderly phenomenon.Chang Shouxian shows that amenorrhea appears in ovulation function unusually.Other are like severe malnutrition, and particularly nervous anorexia, wasting diseases, serious anemia etc. all can influence the synthesis secretion of hypothalamus gonadotropin releasing hormone (GnRH), and cause amenorrhea.Take for a long time some drugs as: reserpine, chlorpromazine, miltown and contraceptive etc. also can cause amenorrhea.Also can influence menstruation during dysfunctions such as the unusual adrenal gland of other endocrine gland, thyroid and pancreas.
Traditional Chinese medical science amenorrhea reason can be divided into two kinds of void, realities clinically.How not enough by natural endowment deficiency syndrome are deficiency of the liver and kindey,, and contain at the kidney qi end, and deficiency of liver-blood is few, dash to appoint and do not fill, living menses of being difficult and cause amenorrhea; Also because of voluminous exhaustion due to sexual indulgence, or the kidney usually involved in chronic disease, cause the kidney essense deficiency of liver-blood, dash appoint all empty, the blood underflow of uterus and cause amenorrhea.Deficient qi and blood: taste are unstrong, and the change source is not enough, or improper diet and overtiredness, are worried excessively damage heart spleen; Or serious disease, prolonged illness, lose blood, or suckling is of a specified duration excessively, causes the nutrient blood loss, dashes to appoint a blood deficiency, depletion of bloodization to give birth to and cause amenorrhea.The plain body deficiency of YIN, or lose blood the moon thanks to, or prolonged illness, heat formation from yin deficiency is burnt and is sought the moon, and the sea of blood dries up and sends out is amenorrhea.The qi depression to blood stasis internal injury caused by excess of seven emotions, depressed stasis, or when producing menstrual period, just open the blood chamber, wound wind and cold or internal injury raw food, and the blood vessels stasis of blood stagnates; Or pathogenic heat are bright cloudy, dash and appoint the stasis of blood to stagnate, the vessels of the uterus obstruct, and cause through water not all right.Stagnation of phlegm-damp, the spleen sun loses warm, the wet expectorant that gathers into, retardance is dashed and is appointed, and vessels of the uterus is jammed and not all right through water.
At present still do not have special method and specific medicine for the treatment of amenorrhea, amenorrhea is general single in the past use western medicine, used treatment such as hormone medicine manual work cycle but side effect is big more, and curative effect is not good enough.In recent years, the Chinese traditional treatment amenorrhea had obtained very great achievement, the outstanding clinical efficacy and the mechanism of action that is comparatively systematically to have studied Chinese medicine, and Application of TCM medicine treatment primary disease has no side effect and has obtained satisfied effect.
Summary of the invention
The problem that the present invention will solve is to above deficiency, and a kind of method for preparing that is used to treat the Chinese medicine composition and the preparation thereof of amenorrhea is provided.
Technical scheme of the present invention is:
A kind of Chinese medicine composition that is used to treat amenorrhea, process by the raw material of following weight portion:
Eupolyphaga Seu Steleophaga 5-15 part, Radix Paeoniae Rubra 15-25 part, Radix Angelicae Sinensis 15-25 part, Rhizoma Chuanxiong 5-15 part, Flos Carthami 10-20 part, Rhizoma Cyperi 15-25 part, Oletum Trogopterori 10-20 part, Pericarpium Citri Reticulatae Viride 5-15 part, Radix Rehmanniae Preparata 15-25 part, Semen Persicae 5-15 part Herba Leonuri 25-35 part and Radix Cyathulae 15-25 part.
Further preferred as technique scheme, said Chinese medicine composition is processed by the raw material of following weight portion:
20 parts of 10 parts of Eupolyphaga Seu Steleophagas, 20 parts of Radix Paeoniae Rubra, 20 parts of Radix Angelicae Sinensis, 10 parts of Rhizoma Chuanxiongs, 15 parts on Flos Carthami, 20 parts of Rhizoma Cyperis, 15 parts of Oletum Trogopteroris, 10 parts on Pericarpium Citri Reticulatae Viride, 20 parts in Radix Rehmanniae Preparata, 10 parts in Semen Persicae, 30 parts of Herba Leonuris and Radix Cyathulaes.
Said Chinese medicine composition pharmaceutical dosage form is: water decoction, unguentum, capsule, tablet, granule, watered pill, honey pill agent or enteric coated tablet.
According to the present invention, a kind of method for preparing of Chinese medicinal composition preparation of amenorrhea of treatment may further comprise the steps:
A, proportionally get each composition of raw material and mix, decocte with water 30 minutes water decoction.
B, with Eupolyphaga Seu Steleophaga, Radix Paeoniae Rubra, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Flos Carthami, Rhizoma Cyperi, Oletum Trogopterori, Pericarpium Citri Reticulatae Viride, Radix Rehmanniae Preparata, Semen Persicae, Herba Leonuri and Radix Cyathulae pulverize separately, mix, add 5-6 and doubly measure 75% alcohol reflux 1-2 hour of volume; Filter; Get filtrating, filtering residue repeats to reflux 2-3 time, merging filtrate; Reclaim ethanol;
C, the filtrating of above-mentioned steps b is condensed into the thick extractum of relative density 1.21～1.25 (80 ℃ record), unguentum.
D, the filtrating of above-mentioned steps b is concentrated into the thick paste shape, gets thick paste, add suitable amount of sucrose and dextrin, process granule, drying is processed 1000 parts (sugar-containing types), obtains granule.
E, the filtrating of above-mentioned steps b is concentrated into the thick paste shape, the shift-in baking oven is dried to moisture for 50-70 ℃ and is lower than 5%, takes out, and crushing screening to 100 order obtains drug powder, adds adjuvant by prior art, processes capsule or enteric coated tablet.
F, proportionally get each composition of raw material and mix, pulverize, cross 80～100 mesh sieves, medicated powder.Medicated powder after sieving used cold boiled water or Sucus Zingberis are general to be piller, cold drying, quality inspection, packing promptly gets watered pill.
G, get sucrose 90g in addition, add water 45ml and refined honey 90g, mix, refine when relative density is about 1.38 (70 ℃ record), filter,, rub the ball bar with the hands with the medicated powder 200g mixing of above-mentioned steps f, pill piece, the pill grain, the heavy 9g of every ball promptly gets honey pill agent.
Preferably, the method for concentration of step c is: take by weighing 50 parts in brown sugar, add the water and 0.1% tartaric acid of brown sugar amount 1/2, heating is tempered, and constantly stirs, and endures when being golden yellow, continues to be concentrated into relative density 1.21～1.25 (80 ℃ record), promptly gets.
The method for concentration of steps d is directly to concentrate not with brown sugar, and gained thick paste relative density 0.8～1.0 (80 ℃ record) gets final product.
In above raw material,
The Pericarpium Citri Reticulatae Viride function with cure mainly soothing the liver dispelling the stagnated QI, removing food stagnancyization stagnates.Be used for distending pain in the chest and hypochondrium, hernia, nodule in the breast, acute mastitis, abdominal pain due to retention of food.
The Flos Carthami function with cure mainly promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.Be used for amenorrhea, dysmenorrhea, lochia is not all right, the abdominal mass mass in the abdomen, injury from falling down, skin infection swells and ache.
Radix Paeoniae Rubra contains paeoniflorin, ability promoting blood circulation to restore menstrual flow, cool the blood dissipate blood stasis, heat-clearing and toxic substances removing.Cure mainly diseases such as amenorrhea due to stagnation of blood, herpes simplex toxic swelling, postnatal blood stasis, heat in blood epistaxis, warm malicious macule.
The Rhizoma Chuanxiong activating QI to alleviate the depression, the method wind-dryness is wet, promoting blood circulation and stopping pain.Control air-cooled headache and revolve dizzyly, the hypochondriac pain abdomen is painful, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation piece pain, ulcer sores.Be used for menoxenia, amenorrhea dysmenorrhea, abdominal mass stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.
Radix Angelicae Sinensis has to enrich blood invigorates blood circulation menstruction regulating and pain relieving, loosening bowel to relieve constipation.Be used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.
Eupolyphaga Seu Steleophaga effect removing blood stasis with potent drugs blood, reuniting the fractured tendons and bones.Be used for the muscles and bones folding and hinder blood stasis amenorrhea, lump in the abdomen mass in the abdomen.
The effect of Rhizoma Cyperi the resolving depression of regulating the flow of vital energy, menstruction regulating and pain relieving.Be used for stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, menoxenia, amenorrhea dysmenorrhea, colic of cold type stomachache, distending pain of the breast.
Oletum Trogopterori function promoting blood circulation to remove blood stasis, the parch to black hemostasis.Be used for trusted subordinate's congestion and have a pain, dysmenorrhea, the blood stasis amenorrhea, puerperal abdominalgia with blood stasis.
Radix Rehmanniae Preparata has the nourishing yin effect of enriching blood, and can be used for blood deficiency and yellow complexion, and is dizzy, palpitation and insomnia, and menoxenia, diseases such as metrorrhagia also can be used for hectic fever hectic fever due to YIN-deficiency, the night sweat of deficiency of kidney yin, disease such as pass out semen, quench one's thirst.
Radix Cyathulae is dispeled the wind, and dampness removing stimulates the menstrual flow, and invigorates blood circulation.The dispelling the wind and dampness pathogens lumbocrural pain, foot flaccidity clonic spasm of the muscle, stranguria with blood, hematuria, women's amenorrhea ， mass in the abdomen.Be used for the amenorrhea lump in the abdomen, retention of placenta, arthralgia, flaccidity of the lower limbs clonic spasm of the muscle, hematuria stranguria with blood, injury from falling down.
The Semen Persicae blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation.Be used for amenorrhea, dysmenorrhea ， WEIJIA mass in the abdomen, injury from falling down, dryness of the intestine constipation.Sweet flat, the bitter in the mouth of Semen Persicae property is gone into lung, liver, large intestine channel; Blood stasis removing and clots absorbing is arranged, moisturize the effect of laxation; Control amenorrhea, dysmenorrhea, abdominal mass abdominal mass mass in the abdomen, traumatic injury, dryness of the intestine constipation.
The Herba Leonuri promoting blood flow to regulate menstruation, inducing diuresis to remove edema.Be used for menoxenia, dysmenorrhea, amenorrhea, lochiorrhea, edema oliguria; Acute nephritis edema.
Its basic pathogenesis of amenorrhea is a deficiency of the liver and kindey: deficient qi and blood: deficiency of YIN blood is dry: qi depression to blood stasis stagnation of phlegm-damp, vessels of the uterus are jammed and are not all right through water.Menstruation is with relevant towards appointing; The married woman is main with blood; The Liver Channel disorder of QI and blood is the main pathogenesis that causes primary disease; So the present invention appoints benefiting blood and regulating blood circulation with Radix Paeoniae Rubra, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, Radix Paeoniae Rubra invigorating the liver and kidney Gu Chong earlier; The Herba Leonuri promoting blood flow to regulate menstruation is key medicine Flos Carthami, the Semen Persicae blood circulation promoting and blood stasis dispelling of regulating menstruation, is key medicine Rhizoma Cyperi, the Oletum Trogopterori Pericarpium Citri Reticulatae Viride depressed liver-energy dispersing and QI regulating of promoting blood circulation to restore menstrual flow removing blood stasis repercussive; Menstruction regulating and pain relieving, Eupolyphaga Seu Steleophaga removing blood stasis with potent drugs blood remove blood stasis and the fresh blood life; Radix Cyathulae restores menstrual flow and invigorates blood circulation, and priming is descending.
The present invention adopts above technical scheme, compared with prior art, has the following advantages: monarch of the present invention, minister, help, make and respectively execute its effect, it is few to have a medication, instant effect, and side effect is little, can reach inside and outside and execute the purpose of giving consideration to both the incidental and fundamental.Can bring out menstruation and remove endometrial thickness and impel it to come off, rather good to the symptom curative effect of amenorrhea and hypomenorrhea, and the prices of raw and semifnished materials are cheap, and simple to operate, therapeutic effect is good, is worthy of popularization.
The specific embodiment
Below in conjunction with embodiment the present invention is described further.
Embodiment 1: a kind of Chinese medicine composition that is used to treat amenorrhea, raw-material weight part is: 20 parts of 10 parts of Eupolyphaga Seu Steleophagas, 20 parts of Radix Paeoniae Rubra, 20 parts of Radix Angelicae Sinensis, 10 parts of Rhizoma Chuanxiongs, 15 parts on Flos Carthami, 20 parts of Rhizoma Cyperis, 15 parts of Oletum Trogopteroris, 10 parts on Pericarpium Citri Reticulatae Viride, 20 parts in Radix Rehmanniae Preparata, 10 parts of Herba Leonuris 30 of Semen Persicae and Radix Cyathulaes.
Embodiment 2: a kind of Chinese medicine composition that is used to treat amenorrhea, raw-material weight part is: 15 parts of 5 parts of Eupolyphaga Seu Steleophagas, 15 parts of Radix Paeoniae Rubra, 15 parts of Radix Angelicae Sinensis, 5 parts of Rhizoma Chuanxiongs, 10 parts on Flos Carthami, 15 parts of Rhizoma Cyperis, 10 parts of Oletum Trogopteroris, 5 parts on Pericarpium Citri Reticulatae Viride, 15 parts in Radix Rehmanniae Preparata, 5 parts of Herba Leonuris 25 of Semen Persicae and Radix Cyathulaes.
Embodiment 3: a kind of Chinese medicine composition that is used to treat amenorrhea, raw-material weight part is: 25 parts of 15 parts of Eupolyphaga Seu Steleophagas, 25 parts of Radix Paeoniae Rubra, 25 parts of Radix Angelicae Sinensis, 15 parts of Rhizoma Chuanxiongs, 20 parts on Flos Carthami, 25 parts of Rhizoma Cyperis, 20 parts of Oletum Trogopteroris, 15 parts on Pericarpium Citri Reticulatae Viride, 25 parts in Radix Rehmanniae Preparata, 15 parts of Herba Leonuris 35 of Semen Persicae and Radix Cyathulaes.
Embodiment 4: the medicine of above embodiment 1-3 is prepared into different dosage forms according to following steps: unguentum, granule, capsule, enteric coated tablet, watered pill, honey pill agent.
A, proportionally get each composition of raw material;
B, Eupolyphaga Seu Steleophaga, Radix Paeoniae Rubra, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Flos Carthami, Rhizoma Cyperi, Oletum Trogopterori, Pericarpium Citri Reticulatae Viride, Radix Rehmanniae Preparata, Semen Persicae, Herba Leonuri and Radix Cyathulae are pulverized successively, mix, add 5-6 and doubly measure 75% alcohol reflux 1-2 hour of volume; Filter; Get filtrating, filtering residue repeats to reflux 2-3 time, merging filtrate; Reclaim ethanol;
C, above-mentioned steps b filtrating are condensed into the thick extractum of relative density 1.21～1.25 (80 ℃ record); Method is: take by weighing 50 parts in brown sugar; Join in the said filtrating; Add the water of brown sugar weight 1/2 and 0.1% tartaric acid; Heating is tempered, and constantly stirs, and endures when being golden yellow; Continue to be concentrated into the relative density of regulation, promptly get unguentum.
D, above-mentioned steps b filtrating are condensed into and are concentrated into the thick paste shape, and relative density 1.0 (80 ℃ record) adds suitable amount of sucrose and dextrin by prior art, processes the granule of 1000 weight portions (sugar-containing type), and drying obtains granule.
C, above-mentioned steps b filtrating is condensed into and is concentrated into the thick paste shape, and the shift-in baking oven is dried to moisture for 50-70 ℃ and is lower than 5%, take out, crushing screening to 100 order, drug powder, add adjuvant by prior art, process capsule or enteric coated tablet.
D, proportionally get each composition of raw material, mix, pulverize, cross 80～100 mesh sieves, medicated powder.Medicated powder after sieving used cold boiled water or Sucus Zingberis are general to be piller, cold drying, quality inspection, packing promptly gets watered pill.
E, get sucrose 90g in addition, add water 45ml and refined honey 90g, mix, refine when relative density is about 1.38 (70 ℃ of mensuration), filter,, rub the ball bar with the hands with the medicated powder 200g mixing of steps d, pill piece, the pill grain, the heavy 9g of every ball promptly gets honey pill agent.
Contrast test: criterion of therapeutical effect; Curative effect determinate standard according to treatment amenorrhea in " new Chinese medicine clinical research guideline ".Clinical recovery: in drug withdrawal 2 cycles, patient's menstrual cycle, normally reach clinical symptom disappearance through amount, through color, through matter, menstrual period.Produce effects; In a drug withdrawal 2-3 cycle, idol has irregular menses 1-2 time, and clinical symptoms is clearly better. Take a turn for the better: 3 of drug withdrawals are more than the cycle, and amenorrhea is arranged idol or through medication and damp person, clinical symptoms partly takes a turn for the better.Invalid: as make moderate progress through the medication clinical symptoms, and menstruation not to be to the person.
Choose 400 routine amenorrhea patients; Picked at random 300 examples are organized as treatment; Other 100 examples are as matched group; Wherein 300 routine patients are divided into treatment group 1, treatment group 2 and treatment group 3; 100 routine patients of each treatment group treatment picked at random; Treatment group 1 uses the unguentum of the embodiment of the invention 1 preparation to treat; Treatment group 2 uses the unguentum of the embodiment of the invention 2 preparations to treat; Treatment group 3 uses the unguentum that carries out of the embodiment of the invention 3 preparations to treat; Each 20ml; Be a course of treatment at twice, 3 month every day.Nonjoinder other treatment method during the treatment.Three menstrual cycle end course of treatment backs are estimated four groups of clinical efficacies.
The patient of matched group adopts elder generation with progestogen (Progesterone), continues and sets up the artificial cycle with the sequential therapy of female-progestogen (diethylstilbestrol), and three menstrual cycle were 1 course of treatment.
Therapeutic outcome such as following table:
Figure BDA0000098819750000041
Can find out that from above tables of data 1 nonresponder is organized in treatment has 10 examples, accounts for 10%.Produce effects 11 examples account for 11%.12 examples that take a turn for the better account for 12%, cure 67 examples, account for 67%, total effective rate 90%, cure rate 67%.The matched group nonresponder has 15 examples, accounts for 15%.Produce effects 17 examples account for 17%.24 examples that take a turn for the better account for 24%, cure 54 examples, account for 54%, and are total effective 85%, cure rate 54%.Treatment group effective percentage cure rate is apparently higher than matched group, and the cure rate effective percentage of treatment group 1 is higher than all the other treatment groups 2 and treatment groups 3, and to organize 1 prescription the most effective in treatment in sum.

Claims (5)

1. Chinese medicine composition that is used to treat amenorrhea, it is characterized in that: said medicine is processed by the raw material of following weight portion: Eupolyphaga Seu Steleophaga 5-15 part, Radix Paeoniae Rubra 15-25 part, Radix Angelicae Sinensis 15-25 part, Rhizoma Chuanxiong 5-15 part, Flos Carthami 10-20 part, Rhizoma Cyperi 15-25 part, Oletum Trogopterori 10-20 part, Pericarpium Citri Reticulatae Viride 5-15 part, Radix Rehmanniae Preparata 15-25 part, Semen Persicae 5-15 part Herba Leonuri 25-35 part and Radix Cyathulae 15-25 part.
2. the Chinese medicine composition that is used to treat amenorrhea as claimed in claim 1 is characterized in that: said raw-material weight part is following: 20 parts of 10 parts of Eupolyphaga Seu Steleophagas, 20 parts of Radix Paeoniae Rubra, 20 parts of Radix Angelicae Sinensis, 10 parts of Rhizoma Chuanxiongs, 15 parts on Flos Carthami, 20 parts of Rhizoma Cyperis, 15 parts of Oletum Trogopteroris, 10 parts on Pericarpium Citri Reticulatae Viride, 20 parts in Radix Rehmanniae Preparata, 10 parts in Semen Persicae, 30 parts of Herba Leonuris and Radix Cyathulaes.
3. the Chinese medicine composition that is used to treat amenorrhea as claimed in claim 1 or 2 is characterized in that: said pharmaceutical dosage form is: water decoction, unguentum, capsule, tablet, granule, watered pill, honey pill agent or enteric coated tablet.
4. the method for preparing of claim 1 or 2 described Chinese medicinal composition preparation may further comprise the steps:
A, proportionally get each composition of raw material and mix, decocte with water 30 minutes water decoction;
B, with Eupolyphaga Seu Steleophaga, Radix Paeoniae Rubra, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Flos Carthami, Rhizoma Cyperi, Oletum Trogopterori, Pericarpium Citri Reticulatae Viride, Radix Rehmanniae Preparata, Semen Persicae, Herba Leonuri and Radix Cyathulae pulverize separately, mix, add 5-6 and doubly measure 75% alcohol reflux 1-2 hour of volume; Filter; Get filtrating, filtering residue repeats to reflux 2-3 time, merging filtrate; Reclaim ethanol;
C, the filtrating of above-mentioned steps b is condensed into the thick extractum of relative density 1.21～1.25 (80 ℃ record), unguentum;
D, the filtrating of above-mentioned steps b is concentrated into the thick paste shape, gets thick paste, add suitable amount of sucrose and dextrin, process granule, drying is processed 1000 parts, obtains granule;
E, the filtrating of above-mentioned steps b is concentrated into the thick paste shape, the shift-in baking oven is dried to moisture for 50-70 ℃ and is lower than 5%, takes out, and crushing screening to 100 order obtains drug powder, adds adjuvant by prior art, processes capsule or enteric coated tablet;
F, proportionally get each composition of raw material and mix, pulverize, cross 80～100 mesh sieves, medicated powder; Medicated powder after sieving used cold boiled water or Sucus Zingberis are general to be piller, cold drying, quality inspection, packing promptly gets watered pill;
G, get sucrose 90g in addition, add water 45ml and refined honey 90g, mix, refine when relative density is about 1.38 (70 ℃ record), filter,, rub the ball bar with the hands with the medicated powder 200g mixing of above-mentioned steps f, pill piece, the pill grain, the heavy 9g of every ball promptly gets honey pill agent.
5. the method for preparing of Chinese medicine preparation as claimed in claim 4; It is characterized in that step c method for concentration is: take by weighing 50 parts in brown sugar; The water and 0.1% tartaric acid that add brown sugar amount 1/2; Heating is tempered; Constantly stir; Endure when being golden yellow, continue to be concentrated into relative density 1.21～1.25 (80 ℃ record), promptly get.
CN2011103125630A 2011-10-14 2011-10-14 Chinese medicinal composition for treating amenorrhea and preparation method of preparation thereof Active CN102343019B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN2011103125630A CN102343019B (en) 2011-10-14 2011-10-14 Chinese medicinal composition for treating amenorrhea and preparation method of preparation thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN2011103125630A CN102343019B (en) 2011-10-14 2011-10-14 Chinese medicinal composition for treating amenorrhea and preparation method of preparation thereof

Publications (2)

Publication Number Publication Date
CN102343019A true CN102343019A (en) 2012-02-08
CN102343019B CN102343019B (en) 2013-05-15

Family

ID=45542340

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2011103125630A Active CN102343019B (en) 2011-10-14 2011-10-14 Chinese medicinal composition for treating amenorrhea and preparation method of preparation thereof

Country Status (1)

Country Link
CN (1) CN102343019B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102920813A (en) * 2012-11-06 2013-02-13 李艳 Chinese medicinal formula for treating amenorrhea after subcutaneous embedding
CN104666792A (en) * 2015-02-01 2015-06-03 胡文杰 Traditional Chinese medicine composition for treating endometrial hyperplasia caused by cold coagulation and blood stasis
CN104721316A (en) * 2015-04-15 2015-06-24 刘卓韬 Traditional Chinese medicine composition and acupuncture point combined application for treating amenorrhea

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101912568A (en) * 2010-07-21 2010-12-15 秦中文 Chinese herbal preparation for regulating menstruation and helping pregnancy

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101912568A (en) * 2010-07-21 2010-12-15 秦中文 Chinese herbal preparation for regulating menstruation and helping pregnancy

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
岳小红等: "张成秀治疗继发性闭经经验", 《甘肃中医》 *
韩萍: "中医辨证治疗闭经的临床体会", 《吉林中医药》 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102920813A (en) * 2012-11-06 2013-02-13 李艳 Chinese medicinal formula for treating amenorrhea after subcutaneous embedding
CN102920813B (en) * 2012-11-06 2014-01-15 李艳 Chinese medicinal formula for treating amenorrhea after subcutaneous embedding
CN104666792A (en) * 2015-02-01 2015-06-03 胡文杰 Traditional Chinese medicine composition for treating endometrial hyperplasia caused by cold coagulation and blood stasis
CN104721316A (en) * 2015-04-15 2015-06-24 刘卓韬 Traditional Chinese medicine composition and acupuncture point combined application for treating amenorrhea

Also Published As

Publication number Publication date
CN102343019B (en) 2013-05-15

Similar Documents

Publication Publication Date Title
CN102210847A (en) Method for preparing medicinal composition capsules for treating dysmenorrheal and application thereof
CN105749179A (en) Traditional Chinese medicine composition for treating metabolic syndrome
CN100496585C (en) Chloasma treating Chinese medicine preparation
CN104922543A (en) Medicine composite for treating amenorrhea and preparation method thereof
CN102120020B (en) Medicinal composition for treating hyperplastic diseases of breast and hysteromyoma and preparation method thereof
CN101961458B (en) Oral medicament for treating osteonecrosis of femoral head
CN104922613A (en) Medicine composite for treating sterility and preparation method thereof
CN106511864A (en) Traditional Chinese medicine composition and preparation method and applications thereof in treatment of cervical carcinoma
CN101869688B (en) Chinese medicinal compound preparation for treating uterine myoma
CN102343019B (en) Chinese medicinal composition for treating amenorrhea and preparation method of preparation thereof
CN103071105B (en) External traditional Chinese medicinal preparation for treating threatened abortion and preparation method thereof
CN101129988A (en) Traditional Chinese medicine preparation for treating post partum lochiorrhea
CN102631655B (en) Medicine for treating coronary heart disease and preparation method for medicine
CN102205064B (en) Traditional Chinese medicine (TCM) for treating threatened abortion
CN102416126A (en) Chinese medicinal combination preparation for treating behcet syndrome and preparation method of Chinese medicinal combination preparation
CN102988946A (en) Traditional Chinese medicine composition for treating pantalgia after childbirth
CN103520354B (en) Traditional Chinese medicine for treatment of blood-insufficiency type mammary gland hyperplasia and preparation method thereof
CN104258360A (en) Traditional Chinese medicine combination for curing menstrual colic and preparation method of preparations thereof
CN104840891A (en) Traditional Chinese medicine preparation used for treating alcoholic cardiomyopathy and preparation method thereof
CN100371016C (en) Chinese traditional medicine preparation for curing mastopathy in installments
CN104491670A (en) Traditional Chinese medicine composition for treating chronic pelvic inflammatory disease
CN104435641A (en) Traditional Chinese medicine preparation for treating hyperthyroidism
CN111658748A (en) Composition for treating dysmenorrhea, oral preparation and application
CN102872290B (en) Chinese medicament for treating menstrual disorder
CN102379913B (en) Pharmaceutical composition for treating subinvolution of uterus, and preparation method and use thereof

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
ASS Succession or assignment of patent right

Owner name: NANJING AOHENG TRADE CO., LTD.

Free format text: FORMER OWNER: SUN FENGQING

Effective date: 20130926

C41 Transfer of patent application or patent right or utility model
COR Change of bibliographic data

Free format text: CORRECT: ADDRESS; FROM: 265100 YANTAI, SHANDONG PROVINCE TO: 226000 NANTONG, JIANGSU PROVINCE

TR01 Transfer of patent right

Effective date of registration: 20130926

Address after: 226000 Century Avenue, Tongzhou Economic Development Zone, Jiangsu, China, No. 289, No.

Patentee after: Nantong Heng Heng Trading Co.,Ltd.

Address before: The third people's Hospital of Haiyang City, No. 3 265100 Shandong city of Yantai province Haiyang City Hai Hua Lu

Patentee before: Sun Fengqing

TR01 Transfer of patent right
TR01 Transfer of patent right

Effective date of registration: 20170401

Address after: 226300 Nantong high tech Zone, Jiangsu province Jinqiao West Road, No. 8, No.

Patentee after: JIANGSU MEIZHONG MEDICAL TECHNOLOGY Co.,Ltd.

Address before: 226000 Century Avenue, Tongzhou Economic Development Zone, Jiangsu, China, No. 289, No.

Patentee before: Nantong Heng Heng Trading Co.,Ltd.

TR01 Transfer of patent right

Effective date of registration: 20230713

Address after: 222, A2 Building, Jianghai Zhihui Park, 1188 New Century Avenue, Nantong Hi tech Industrial Development Zone, Jiangsu Province, 226000

Patentee after: Nantong San Intellectual Property Service Co.,Ltd.

Address before: 226300 No.8, Jinqiao West Road, Nantong high tech Zone, Nantong City, Jiangsu Province

Patentee before: JIANGSU MEIZHONG MEDICAL TECHNOLOGY Co.,Ltd.

TR01 Transfer of patent right
EE01 Entry into force of recordation of patent licensing contract
EE01 Entry into force of recordation of patent licensing contract

Application publication date: 20120208

Assignee: Jiangsu Yichuang Packaging Materials Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048413

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231129

Application publication date: 20120208

Assignee: Nantong Jingxuan Textile Technology Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048319

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231127

Application publication date: 20120208

Assignee: Nantong Huanlian Textile Technology Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048315

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231127

Application publication date: 20120208

Assignee: Nantong Huase Space Textile Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048606

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231129

Application publication date: 20120208

Assignee: Nantong Anergu New Material Technology Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048605

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231129

Application publication date: 20120208

Assignee: Nantong Laiou Electronic Technology Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048604

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231129

Application publication date: 20120208

Assignee: Yitong Intelligent Control Technology (Nantong) Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048603

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231129

Application publication date: 20120208

Assignee: Nantong Ouchen Electronic Technology Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048602

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231129

Application publication date: 20120208

Assignee: Nantong Laishang Electronic Technology Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048601

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231129

Application publication date: 20120208

Assignee: Nantong Lingde Pharmaceutical Equipment Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048600

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231129

Application publication date: 20120208

Assignee: Nantong Chujie Electronic Equipment Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048597

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231129

Application publication date: 20120208

Assignee: Nantong Jiaerjie Labor Care Products Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048596

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231129

Application publication date: 20120208

Assignee: JIANGSU KANGFEITE POWER TECHNOLOGY Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048594

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231129

Application publication date: 20120208

Assignee: Nantong Tuoerpu Surveying and Mapping Information Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048583

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231128

Application publication date: 20120208

Assignee: Nantong TongZhou Jinfeng Textile Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048582

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231128

Application publication date: 20120208

Assignee: Nantong Weiai Home Textile Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048563

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231129

Application publication date: 20120208

Assignee: Nantong Qiju Textile Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048556

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231128

Application publication date: 20120208

Assignee: Nantong Juguang Trading Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048551

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231128

Application publication date: 20120208

Assignee: Nantong Chenghui Pharmacy Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048548

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231128

Application publication date: 20120208

Assignee: Nantong Tongzhou Kangxintang Drugstore Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048542

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231128

Application publication date: 20120208

Assignee: Nantong Tuanpinhui E-commerce Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048537

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231128

Application publication date: 20120208

Assignee: Nantong Koushun E-commerce Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048506

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231128

Application publication date: 20120208

Assignee: Nantong Tuoda Machinery Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048494

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231128

Application publication date: 20120208

Assignee: Weizhi New Material Technology (Nantong) Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048487

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231128

Application publication date: 20120208

Assignee: NANTONG FEIHAI ELECTRONIC TECHNOLOGY CO.,LTD.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048483

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231128

Application publication date: 20120208

Assignee: Haoshi new material technology Nantong Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048475

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231128

Application publication date: 20120208

Assignee: Nantong Steel Machinery Manufacturing Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048466

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231128

Application publication date: 20120208

Assignee: NANTONG YUQI METAL PRODUCTS Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048459

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231129

Application publication date: 20120208

Assignee: NANTONG KYLIN MACHINERY LTD.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048456

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231129

Application publication date: 20120208

Assignee: NANTONG LILIAN MACHINE TOOL MANUFACTURING CO.,LTD.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048450

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231129

Application publication date: 20120208

Assignee: Nantong Yuma Electromechanical Manufacturing Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048446

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231129

Application publication date: 20120208

Assignee: Nantong Dongdong Steel Structure Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048444

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231129

Application publication date: 20120208

Assignee: Nantong Huaxin Price Evaluation Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048443

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231129

Application publication date: 20120208

Assignee: Nantong Yaocheng mechanical equipment manufacturing Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048440

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231129

Application publication date: 20120208

Assignee: Nantong Xinxin Pharmaceutical Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048425

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231129

EE01 Entry into force of recordation of patent licensing contract

Application publication date: 20120208

Assignee: Nantong Yijialai Woolen Knitting Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980049377

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231203

Application publication date: 20120208

Assignee: NANTONG BEITE PHARMACEUTICAL MACHINERY Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980049199

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231203

Application publication date: 20120208

Assignee: NANTONG HAIGUO MACHINERY Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980049196

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231203

Application publication date: 20120208

Assignee: Nantong Qiaojiang packaging materials Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980049191

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231203

Application publication date: 20120208

Assignee: Nantong Bairun Catering Management Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980049185

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231203

Application publication date: 20120208

Assignee: Nantong Nongchaoer Food Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048976

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231203

Application publication date: 20120208

Assignee: Xingren Tank Farm of Nantong Xinhai Liquefied Gas Service Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048969

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231203

Application publication date: 20120208

Assignee: NANTONG SHUANGHE FOOD Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048967

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231203

Application publication date: 20120208

Assignee: Jiangsu guanan electromechanical Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048961

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231203

Application publication date: 20120208

Assignee: Nantong Runyuan structural parts Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048952

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231203

Application publication date: 20120208

Assignee: Nantong Jinbao Machinery Manufacturing Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048947

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231202

Application publication date: 20120208

Assignee: Nantong Juntai motor vehicle testing Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048942

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231202

Application publication date: 20120208

Assignee: Honglei mechanical equipment (Nantong) Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048782

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231202

Application publication date: 20120208

Assignee: American Antelope Home Textile (Nantong) Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048774

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231202

Application publication date: 20120208

Assignee: Nantong Ansheng Textile Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048765

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231130

Application publication date: 20120208

Assignee: NANTONG YA TAI CANDLE ARTS & CRAFTS Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048764

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231130

Application publication date: 20120208

Assignee: Nantong Jianwei Metal Technology Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048759

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231202

Application publication date: 20120208

Assignee: JIANGSU YATAI FITNESS CO.,LTD.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980048748

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231202

EE01 Entry into force of recordation of patent licensing contract
EE01 Entry into force of recordation of patent licensing contract

Application publication date: 20120208

Assignee: Nantong Zhili Machinery Technology Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2023980049698

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20231205

EE01 Entry into force of recordation of patent licensing contract
OL01 Intention to license declared
OL01 Intention to license declared
EE01 Entry into force of recordation of patent licensing contract

Application publication date: 20120208

Assignee: JIANGSU HAOHAN INFORMATION TECHNOLOGY Co.,Ltd.

Assignor: Nantong San Intellectual Property Service Co.,Ltd.

Contract record no.: X2024980003183

Denomination of invention: A method for preparing a traditional Chinese medicine composition and its preparation for treating amenorrhea

Granted publication date: 20130515

License type: Common License

Record date: 20240322

EE01 Entry into force of recordation of patent licensing contract