CN104258360A - Traditional Chinese medicine combination for curing menstrual colic and preparation method of preparations thereof - Google Patents

Traditional Chinese medicine combination for curing menstrual colic and preparation method of preparations thereof Download PDF

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CN104258360A
CN104258360A CN201410555567.5A CN201410555567A CN104258360A CN 104258360 A CN104258360 A CN 104258360A CN 201410555567 A CN201410555567 A CN 201410555567A CN 104258360 A CN104258360 A CN 104258360A
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chinese medicine
rhizoma
radix
dysmenorrhea
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刘志霞
杨绍辉
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • A61K36/076Poria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236Ligusticum (licorice-root)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/238Saposhnikovia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282Artemisia, e.g. wormwood or sagebrush
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/54Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/65Paeoniaceae (Peony family), e.g. Chinese peony
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • A61K36/804Rehmannia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/89Cyperaceae (Sedge family)
    • A61K36/8905Cyperus (flatsedge)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9066Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9068Zingiber, e.g. garden ginger
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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    • A61K9/00Medicinal preparations characterised by special physical form
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    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
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    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2068Compounds of unknown constitution, e.g. material from plants or animals
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Abstract

The invention discloses a traditional Chinese medicine combination for curing menstrual colic. The traditional Chinese medicine combination is prepared by 25 to 35 parts of Chinese angelica root, 15 to 25 parts of rhizome of Sichuan lovage, 6 to 10 parts of cassia bark, 15 to 25 parts of cyperirhizome, 25 to 35 parts of fox glove, 15 to 25 parts of ledebouriella root, 6 to 10 parts of fresh ginger, 6 to 10 parts of leaf of argyi wormwood, 10 to 20 parts of Indian bread, 15 to 25 parts of red peony root, and 5 to 15 parts of zedoary. The preparations of the traditional Chinese medicine combination comprise the followings: water decoction, capsule, tablet, granules, water pill and honeyed pill. According to the characteristic of repeated attack of menstrual colic, the traditional Chinese medicine combination for curing menstrual colic does not have side-effects of chemical drugs, and can be taken for a long time.

Description

A kind ofly be used for the treatment of the Chinese medicine composition of dysmenorrhea and the preparation method of preparation thereof
Technical field
The present invention relates to and be a kind ofly used for the treatment of the Chinese medicine composition of dysmenorrhea and the preparation method of preparation thereof, belong to tcm field.
Background technology
Dysmenorrhea is common symptom in women, one of common gynaecopathia, and sickness rate is very high, causes the factor of dysmenorrhea a lot, common are following several: 1, the narrow mainly menstruation outflow of cervical canal is obstructed, and causes dysmenorrhea.2, the not good easy merging blood supply of uterine hypoplasia developing womb is abnormal, causes uterus ischemia, anoxia and cause dysmenorrhea.If 3, lagedes uterus uterus position extremely after to bend or anteflexion, the unobstructed and induced pain warp of menses can be affected.4, spirit, neural factors some women are to pain extrasensitivity.5, there is dysmenorrhea and mother's dysmenorrhea has certain relation in inherited genetic factors daughter.6, endocrine factors menstrual phase stomachache raises relevant with progesterone luteal phase.7, in endometrium and menstrual blood, Prostaglandin raises, and PGE2 (PGE2) acts on uterus muscle fiber and makes it contraction and cause dysmenorrhea.In patient uterine internal film tissue, Prostaglandin normal women obviously raises.8, the excess shrinkage in uterus.Although dysmenorrhea patient uterine systolic pressure is substantially identical with normal women, duration of uterine contraction is longer, and often not easily loosens completely, therefore the dysmenorrhea caused by the excess shrinkage of occurrence factor palace.9, the abnormal contraction in uterus.Dysmenorrhea patient often has the abnormal contraction in uterus, therefore often causes uterine leio myocardial ischemia, and the ischemia of uterus muscle can cause again the spasmodic contraction of uterus muscle, thus produces pain and occur dysmenorrhea.10, gynaecopathia is as endometriosis, pelvic inflammatory disease, adenomyosis, hysteromyoma etc.Intrauterine is placed birth control apparatus and is also easily caused dysmenorrhea.11, maiden's menophania, mental pressure is large, sitting causes qi-blood circulating variation, menses run freely, like that eating cold drink food etc. causes dysmenorrhea.12, menstrual period strenuous exercise, clammy invasion and attack etc. of having a cold, all easily cause dysmenorrhea.The treatment mainly symptomatic treatment of dysmenorrhea, with pain relieving, calmness is main, all adopts Comprehensive Treatment to comprise spirit in recent years and dredges, Chinese medicine, Western medicine and acupuncture and moxibustion therapy, the medicine that Drug therapy major prostaglandin synthetase inhibitors is conventional has ibuprofen, ketoprofen, meclofenamic acid, diclofenac etc.Oral contraceptive is applicable to the dysmenorrhea women requiring contraception, and analgesic effect is obvious, but recurrent exerbation rate is high, be not easy to eradicate disease, the present invention is directed to the feature of dysmenorrhea recurrent exerbation, a kind of Chinese medicine preparation eradicating dysmenorrhea is provided, feature is the side effect without chemicals, and evident in efficacy.
Summary of the invention
The problem to be solved in the present invention is for above deficiency, provides a kind of and is used for the treatment of the Chinese medicine composition of dysmenorrhea and the preparation method of preparation thereof.
Technical scheme of the present invention is:
Be used for the treatment of a Chinese medicine composition for dysmenorrhea, be made up of the raw material of following weight portion:
Radix Angelicae Sinensis 25-35 part Rhizoma Chuanxiong 15-25 part Cortex Cinnamomi 6-10 part Rhizoma Cyperi 15-25 part Radix Rehmanniae Preparata 25-35 part Radix Saposhnikoviae 15-25 part Rhizoma Zingiberis Recens 6-10 part Folium Artemisiae Argyi 6-10 part Poria 10-20 part Radix Paeoniae Rubra 15-25 part Rhizoma Curcumae 5-15 part.
As technique scheme further preferably, described Chinese medicine composition is made up of the raw material of following weight portion:
Radix Angelicae Sinensis 30 parts of Rhizoma Chuanxiongs 20 portions of Cortex Cinnamomis 8 portions of Rhizoma Cyperis 20 parts of Radix Rehmanniaes Preparata 30 parts of Radix Saposhnikoviaes 20 portions of Rhizoma Zingiberis Recenss 8 portions of Folium Artemisiae Argyis 8 parts of Poria 15 parts of Radix Paeoniae Rubra 20 parts of Rhizoma Curcumae 10 parts.
Described Chinese medicine composition pharmaceutical dosage form is: water decoction, capsule, tablet, granule, watered pill, honey pill agent.
According to the present invention, prepare a kind of method for the treatment of the Chinese medicinal composition preparation of dysmenorrhea, comprise the following steps:
A, by Radix Angelicae Sinensis, Rhizoma Chuanxiong, Cortex Cinnamomi, Rhizoma Cyperi, Radix Rehmanniae Preparata, Radix Saposhnikoviae, Rhizoma Zingiberis Recens, Folium Artemisiae Argyi, Poria, Radix Paeoniae Rubra, Rhizoma Curcumae is pulverized respectively, mixing, add 75% alcohol reflux 1-2 hour of 5-6 times amount volume, filter, get filtrate, filtering residue repeat backflow 2-3 time, merging filtrate; Reclaim ethanol;
B, the filtrate of above-mentioned steps a is condensed into the thick extractum that 80 DEG C record relative density 1.21 ~ 1.25, obtains unguentum;
C, the filtrate of above-mentioned steps b is concentrated into paste, gets thick paste, add appropriate sucrose and dextrin, make granule, dry, make 1000 parts (sugar-containing types), obtain granule;
D, the filtrate of above-mentioned steps b is concentrated into paste, shift-in baking oven, dries to moisture lower than 5%, take out, pulverize and sieve to 100 orders, obtain drug powder, add adjuvant by prior art, make capsule or enteric coated tablet for 50-70 DEG C;
E, proportionally get each composition of raw material mixing, pulverize, cross 80 ~ 100 mesh sieves, obtain medicated powder.By the cold boiled water of medicated powder after sieving or Sucus Zingberis general be piller, cold drying, quality inspection, packs and obtains watered pill;
F, separately get sucrose 90g, add water 45ml and refined honey 90g, mixing, and when refining to refining is measured as 1.38 to relative density 70 DEG C, filters, mix, pill block with the medicated powder 200g of above-mentioned steps f, rub ball bar with the hands, pill grain, every ball weighs 9g, obtains honey pill agent.
According to the present invention, a kind of water decoction for the treatment of the Chinese medicinal composition preparation of gestation reaction:
Proportionally get the mixing of each composition of raw material, decoct with water 30 minutes and obtain water decoction.
In above raw material:
Radix Angelicae Sinensis: warm in nature, sweet in the mouth is pungent.GUIXIN, liver, spleen channel.Benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturizes laxation.Control menoxenia, amenorrhea is suffered from abdominal pain, and lump in the abdomen knot is poly-, metrorrhagia; Headache due to deficiency of blood, dizzy, flaccidity syndrome and arthralgia syndrome; Dryness of the intestine dyschezia is heavy after bloody dysentery; Carbuncle skin ulcer is stolen, injury from falling down.
Rhizoma Chuanxiong: blood-activating and qi-promoting, wind-expelling pain-stopping.Have a headache for positive wind syndrome of head, lump in the abdomen is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, and headache rheumatic arthralgia, activating QI to alleviate the depression, method wind-dryness is wet, promoting blood circulation and stopping pain.Controlling air-cooled headache revolves dizzy, and hypochondriac pain abdomen aches, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores.For menoxenia, amenorrhea dysmenorrhea, abdominal mass is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.
Cortex Cinnamomi: Cortex Cinnamomi is pungent, sweet, hot greatly, return kidney, spleen, the heart, Liver Channel; Effect of Cortex Cinnamomi: mend fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.
Rhizoma Cyperi: pungent micro-hardship is sweet, flat.Enter lung, liver, spleen, stomach four warp.Regulate the flow of vital energy resolving depression, menstruction regulating and pain relieving, is used for the treatment of stagnation of QI due to depression of the liver, breast, side of body abdominal distention, dyspepsia, menoxenia, amenorrhea dysmenorrhea
Radix Rehmanniae Preparata: enrich blood moist; Benefit essence fills out marrow.For blood deficiency and yellow complexion; Dizzy cardiopalmus; Menoxenia;
Radix Saposhnikoviae: expelling pathogenic wind from the body surface, removing dampness to relieve pain, spasmolytic, antipruritic
Rhizoma Zingiberis Recens:: Rhizoma Zingiberis Recens acrid in the mouth, warm in nature. return lung, spleen, stomach warp. effect is induced sweat cold expelling, warming middle-JIAO arresting vomiting by invigorating the stomach, preventing phlegm from forming and stopping coughing. Rhizoma Zingiberis, acrid in the mouth, warm in nature. main fullness in the chest cough with dyspnea, warming middle-JIAO stops blooding, and perspires
Folium Artemisiae Argyi: toil, temperature.Enter spleen, liver, kidney channel.To regulate the flow of vital energy blood, by cold-damp; Warming the meridian, hemostasis, antiabortive.Control trusted subordinate's cold type of pain, convulsion of having loose bowels, chronic dysentery, tells nosebleed, hematochezia, menoxenia
Radix Paeoniae Rubra energy promoting blood circulation to restore menstrual flow, cool the blood dissipate blood stasis, heat-clearing and toxic substances removing.Cure mainly the diseases such as amenorrhea due to stagnation of blood, herpes simplex toxic swelling, postnatal blood stasis, heat in blood epistaxis, warm malicious macule
Poria function promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia
The circulation of qi promoting of Rhizoma Curcumae removing blood stasis, removing food stagnancy pain relieving.For abdominal pain due to blood stasis, hepatosplenomegaly, trusted subordinate's distending pain, gather, women's blood stasis amenorrhea:
The present invention adopts above technical scheme, compared with prior art, has the following advantages: monarch of the present invention, minister, help, make respectively to execute its effect, and have medication few, instant effect, side effect is little, can reach inside and outside and execute, the object of giving consideration to both the incidental and fundamental.Rather good to dysmenorrhea curative effect, can long-term taking, and the prices of raw and semifnished materials are cheap, simple to operate, therapeutic effect is good, is worthy of popularization.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described.
Embodiment 1: a kind of Chinese medicine composition being used for the treatment of dysmenorrhea, raw-material weight part is: a kind of Chinese medicine composition being used for the treatment of acne, and raw-material weight part is: Radix Angelicae Sinensis 30 parts of Rhizoma Chuanxiongs 20 portions of Cortex Cinnamomis 8 portions of Rhizoma Cyperis 20 parts of Radix Rehmanniaes Preparata 30 parts of Radix Saposhnikoviaes 20 portions of Rhizoma Zingiberis Recenss 8 portions of Folium Artemisiae Argyis 8 parts of Poria 15 parts of Radix Paeoniae Rubra 20 parts of Rhizoma Curcumae 10 parts
Embodiment 2: a kind of Chinese medicine composition being used for the treatment of dysmenorrhea, raw-material weight part is: Radix Angelicae Sinensis 25 parts of Rhizoma Chuanxiongs 15 portions of Cortex Cinnamomis 6 portions of Rhizoma Cyperis 15 parts of Radix Rehmanniaes Preparata 25 parts of Radix Saposhnikoviaes 15 portions of Rhizoma Zingiberis Recenss 6 portions of Folium Artemisiae Argyis 6 parts of Poria 10 parts of Radix Paeoniae Rubra 15 parts of Rhizoma Curcumae 5 parts
Embodiment 3: a kind of Chinese medicine composition being used for the treatment of dysmenorrhea, raw-material weight part is: Radix Angelicae Sinensis 35 parts of Rhizoma Chuanxiongs 25 portions of Cortex Cinnamomis 10 portions of Rhizoma Cyperis 25 parts of Radix Rehmanniaes Preparata 35 parts of Radix Saposhnikoviaes 25 portions of Rhizoma Zingiberis Recenss 10 portions of Folium Artemisiae Argyis 10 parts of Poria 20 parts of Radix Paeoniae Rubra 25 parts of Rhizoma Curcumae 15 parts
Embodiment 4: the medicine of above embodiment 1-3 is prepared into different dosage forms according to following steps: water decoction, unguentum, granule, capsule, enteric coated tablet, watered pill, honey pill agent.:
A, by Radix Angelicae Sinensis, Rhizoma Chuanxiong, Cortex Cinnamomi, Rhizoma Cyperi, Radix Rehmanniae Preparata, Radix Saposhnikoviae, Rhizoma Zingiberis Recens, Folium Artemisiae Argyi, Poria, Radix Paeoniae Rubra, Rhizoma Curcumae is pulverized respectively, mixing, add 75% alcohol reflux 1-2 hour of 5-6 times amount volume, filter, get filtrate, filtering residue repeat backflow 2-3 time, merging filtrate; Reclaim ethanol;
B, the filtrate of above-mentioned steps b is condensed into the thick extractum that 80 DEG C record relative density 1.21 ~ 1.25, obtains unguentum;
C, the filtrate of above-mentioned steps b is concentrated into paste, gets thick paste, add appropriate sucrose and dextrin, make granule, dry, make 1000 parts (sugar-containing types), obtain granule;
D, the filtrate of above-mentioned steps b is concentrated into paste, shift-in baking oven, dries to moisture lower than 5%, take out, pulverize and sieve to 100 orders, obtain drug powder, add adjuvant by prior art, make capsule or enteric coated tablet for 50-70 DEG C;
E, proportionally get each composition of raw material mixing, pulverize, cross 80 ~ 100 mesh sieves, obtain medicated powder.By the cold boiled water of medicated powder after sieving or Sucus Zingberis general be piller, cold drying, quality inspection, packs and obtains watered pill;
F, separately get sucrose 90g, add water 45ml and refined honey 90g, mixing, and when refining to refining is measured as 1.38 to relative density 70 DEG C, filters, mix, pill block with the medicated powder 200g of above-mentioned steps f, rub ball bar with the hands, pill grain, every ball weighs 9g, obtains honey pill agent.
Proportionally get the mixing of each composition of raw material, decoct with water 30 minutes and obtain water decoction.
Testing data:
3 degree can be divided into according to pain degree:
(1) slight: menstrual period or before and after it lower abdomen pain obvious, companion's waist is ached, but can adhere to work, without General Symptoms, sometimes needs to take analgesic.
(2) moderate: menstrual period or lower abdomen hurt like hell before and after it, companion's waist is ached, and nausea and vomiting, extremity are not warm, postpone by pain relieving measure pain.
(3) severe: menstrual period or lower abdomen hurt like hell before and after it, feels restless, has a strong impact on work and study and daily life, must lie up, companion's waist is ached, pale complexion, dripping cold sweat, extreme cold of the limbs, vomiting and diarrhoea, or rectal tenesmus, adopt pain relieving measure without obvious alleviation.
Observation of curative effect:
Efficacy assessment standard adopts " TCM Gynecology Illnesses Diagnoses criterion of therapeutical effect ": cure: pain disappears, and continuous 3 cycles have no recurrence.Take a turn for the better: pain relief or pain disappear, but can not maintain more than 3 months.Invalid (not healing): pain has no improvement.
Choose 400 routine dysmenorrhea patients, random selecting 300 example is as treatment group, other 100 examples as a control group, wherein 300 routine patients are divided into treatment group 1, treatment group 2 and treatment group 3,100 routine patients of each treatment group treatment random selecting, treatment group 1 uses the water decoction of the embodiment of the present invention 1 to treat, and treatment group 2 uses the water decoction of the embodiment of the present invention 2 to treat, and treatment group 3 uses the water decoction of the embodiment of the present invention 3 to treat. and three menstrual cycle are a course for the treatment of
The patient of matched group adopts ibuprofen for oral administration.
Therapeutic outcome is as following table:
As can be seen from above tables of data, treatment group effective percentage cure rate is apparently higher than matched group, and the cure rate effective percentage for the treatment of group 1 is higher than all the other treatment groups 2 and treatment group 3, and treatment group 1 prescription is the most effective in sum.

Claims (4)

1. be used for the treatment of a Chinese medicine composition for dysmenorrhea, be made up of the raw material of following weight portion:
Radix Angelicae Sinensis 25-35 part, Rhizoma Chuanxiong 15-25 part, Cortex Cinnamomi 6-10 part, Rhizoma Cyperi 15-25 part, Radix Rehmanniae Preparata 25-35 part, Radix Saposhnikoviae 15-25 part, Rhizoma Zingiberis Recens 6-10, Folium Artemisiae Argyi 6-10 part, Poria 10-20 part, Radix Paeoniae Rubra 15-25 part, Rhizoma Curcumae 5-15 part.
2. a kind of Chinese medicine composition being used for the treatment of dysmenorrhea as claimed in claim 1, be made up of the raw material of following weight portion:
Radix Angelicae Sinensis 30 parts of Rhizoma Chuanxiongs 20 portions of Cortex Cinnamomis 8 portions of Rhizoma Cyperis 20 parts of Radix Rehmanniaes Preparata 30 parts of Radix Saposhnikoviaes 20 portions of Rhizoma Zingiberis Recenss 8 portions of Folium Artemisiae Argyis 8 parts of Poria 15 parts of Radix Paeoniae Rubra 20 parts of Rhizoma Curcumae 10 parts
3. preparation a kind of method being used for the treatment of the Chinese medicine composition of dysmenorrhea as claimed in claim 1 or 2, comprises the following steps:
A, general: Radix Angelicae Sinensis, Rhizoma Chuanxiong, Cortex Cinnamomi, Rhizoma Cyperi, Radix Rehmanniae Preparata, Radix Saposhnikoviae, Rhizoma Zingiberis Recens, Folium Artemisiae Argyi, Poria, Radix Paeoniae Rubra, Rhizoma Curcumae are pulverized respectively, mixing, add 75% alcohol reflux 1-2 hour of 5-6 times amount volume, filter, get filtrate, filtering residue repeats backflow 2-3 time, merging filtrate; Reclaim ethanol;
B, the filtrate of above-mentioned steps a is condensed into the thick extractum that 80 DEG C record relative density 1.21 ~ 1.25, obtains unguentum;
C, the filtrate of above-mentioned steps b is concentrated into paste, gets thick paste, add appropriate sucrose and dextrin, make granule, dry, make 1000 parts (sugar-containing types), obtain granule;
D, the filtrate of above-mentioned steps b is concentrated into paste, shift-in baking oven, dries to moisture lower than 5%, take out, pulverize and sieve to 100 orders, obtain drug powder, add adjuvant by prior art, make capsule or enteric coated tablet for 50-70 DEG C;
E, proportionally get each composition of raw material mixing, pulverize, cross 80 ~ 100 mesh sieves, obtain medicated powder.By the cold boiled water of medicated powder after sieving or Sucus Zingberis general be piller, cold drying, quality inspection, packs and obtains watered pill;
F, separately get sucrose 90g, add water 45ml and refined honey 90g, mixing, and when refining to refining is measured as 1.38 to relative density 70 DEG C, filters, mix, pill block with the medicated powder 200g of above-mentioned steps d, rub ball bar with the hands, pill grain, every ball weighs 9g, obtains honey pill agent.
4. a kind of Chinese medicine composition being used for the treatment of dysmenorrhea as claimed in claim 1 or 2, described Chinese medicine composition pharmaceutical dosage form is: water decoction, capsule, tablet, granule, watered pill, honey pill agent.
CN201410555567.5A 2014-10-14 2014-10-14 Traditional Chinese medicine combination for curing menstrual colic and preparation method of preparations thereof Pending CN104258360A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108392605A (en) * 2017-02-07 2018-08-14 燕巧红 Dissolving stasis decoction for promoting blood circulation
CN109364234A (en) * 2018-12-29 2019-02-22 珠海易衡慧健康科技有限公司 A kind of gynecologic medicine product promoting blood circulation and removing obstruction in channels, stasis-dispelling and pain-killing and preparation method thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103432559A (en) * 2013-09-06 2013-12-11 大连民族学院 Traditional Chinese medicine composition for treating spanomenorrhea and dysmenorrhea caused by blood stasis and preparation method and application thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103432559A (en) * 2013-09-06 2013-12-11 大连民族学院 Traditional Chinese medicine composition for treating spanomenorrhea and dysmenorrhea caused by blood stasis and preparation method and application thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108392605A (en) * 2017-02-07 2018-08-14 燕巧红 Dissolving stasis decoction for promoting blood circulation
CN109364234A (en) * 2018-12-29 2019-02-22 珠海易衡慧健康科技有限公司 A kind of gynecologic medicine product promoting blood circulation and removing obstruction in channels, stasis-dispelling and pain-killing and preparation method thereof

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Application publication date: 20150107