CN102894372A - Health-care food for increasing bone density and preparation method thereof - Google Patents
Health-care food for increasing bone density and preparation method thereof Download PDFInfo
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- CN102894372A CN102894372A CN201210438242XA CN201210438242A CN102894372A CN 102894372 A CN102894372 A CN 102894372A CN 201210438242X A CN201210438242X A CN 201210438242XA CN 201210438242 A CN201210438242 A CN 201210438242A CN 102894372 A CN102894372 A CN 102894372A
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Abstract
The invention discloses health-care food for increasing bone density and a preparation method thereof. The health-care food consists of the following components in percentage by weight: 30 to 35 percent of calcium carbonate, 15 to 20 percent of chondroitin sulfate, 20 to 25 percent of glucosamine sulfate, 10 to 15 percent of collagen, 0.05 to 0.1 percent of vitamin D3, 2.5 to 5 percent of sodium hyaluronate, 8 to 10 percent of starch and 1 to 2 percent of magnesium stearate. The health-care food is prepared by crushing the components, sieving and mixing. The health-care food is scientific in formula and compatibility, incompatibility is avoided, the intake of calcium can be increased, the deposition of bone mineral substances in skeletons can also be promoted, the fixing effect of bone tissues on the calcium is improved, the absorption of trace elements of the calcium, phosphorus and the like is promoted, and calcium loss is avoided; and the health-care food can achieve the effect of increasing the bone density when eaten for a long time, is safe and does not have side effects.
Description
Technical field
The present invention relates to a kind of health food and preparation method thereof, particularly a kind of health food of increasing bone density and preparation method thereof that helps.
Background technology
It is 75%～85% relevant with bone density (BMD) that the intensity of bone tissue has.The bone density of bone density phalanges unit are refers to the tightness degree (BMD) of bone tissue combination be often referred to bone mineral content (BMC).Being to weigh at present an osteoporotic index that objectively quantizes, also is an index of reflection bone amount, and bone density is higher, and sclerotin intensity is better.The factor analysis such as it and skeletal structure, bone amount, bone mineral content.
Along with wearing out of age, the BMD of each bone of the whole body all is gradually downward trend, and the BMD of neck of femur is between 20 ~ 90 years old, and the women will descend 58%, and the male sex will descend 39%; The femoral intertrochanteric district then descends respectively 53% and 35%.BMD drops to a certain degree, is easy to fracture.Along with human longevity increases and the aging population process, osteoporosis becomes the one of the main reasons that threatens the elderly healthy, therefore the medical treatment and the burden on society that cause, become global public health problem, be 67.6% in population more than 59 years old according to Population Forecasting model measuring incidence of osteoporosis, the elderly woman incidence of osteoporosis was up to 50%-70% in wherein 60 years old-69 years old.If add a middle-aged person, this numeral can be huger.A statistical report shows that the incidence of disease of primary osteoporosis increases with advancing age accordingly, and the bone density lumbar vertebrae normotopia of whole body and the bone density of lateral lumber spine and age all are negative correlation.Along with expanding economy, rhythm of life is constantly accelerated, and increasing people have ignored healthy, have ignored calcareous continuous loss in the body, so that incidence of osteoporosis is more and more higher, should cause people's concern.Increase bone density, effectively treat the important topic that osteoporosis has become people's extensive concern.
The national OTC of the increase bone substance density improving function of examining through State Food and Drug Administration is greatly about kind more than 100, the existing market product variety, the health food that increases bone density is divided into two classes substantially: a class is calcic, reach the health food that increases the bone density purpose by direct supplement calcium; Another kind of is calcic or not replenishing the calcium as purpose not, thus but the health food that promotes that by adjusting endocrine the absorption of calcium reaches increases bone density this purpose.These health food product components that increase bone densities are single, and action pathway is also more single, demand that can not satisfying the market.
Summary of the invention
The purpose of this invention is to provide a kind of health food that increases bone density and preparation method thereof, the various composition reasonable formula in this health food, cooperate to share, by number of ways, realize the increase of bone density at many levels; And preparation method provided by the invention, easy to operate.
In order to solve the problems of the technologies described above, a kind of health food that increases bone density of the present invention consists of the following composition, and counts by weight percentage: calcium carbonate 30-35%, chondroitin sulfate 15-20%, aminoglucose sulfate 20-25%, collagen 10-15%, vitamin D
30.05-0.1%, Sodium Hyaluronate 2.5-5%, starch 8-10%, dolomol 1-2%.
The health food of above-mentioned increase bone density, wherein, preferred component is calcium carbonate 32.5%, chondroitin sulfate 17.5%, aminoglucose sulfate 22.5%, collagen 12.5%, vitamin D
30.1%, Sodium Hyaluronate 4.5%, starch 9%, dolomol 1.40%.
The health food of above-mentioned increase bone density, wherein, the granularity of calcium carbonate, chondroitin sulfate, aminoglucose sulfate, collagen, Sodium Hyaluronate, starch is 60-80.
The health food of above-mentioned increase bone density, wherein, the formulation of described health food can be particle, capsule and tablet.
The health food of above-mentioned increase bone density, wherein, the formulation of described health food is preferably capsule.
The preparation method of the health food of above-mentioned increase bone density comprises the steps:
A. pulverize, sieve: with calcium carbonate, chondroitin sulfate, aminoglucose sulfate difference crushing screening, for subsequent use, making its degree is the 60-80 order; Collagen, Sodium Hyaluronate, starch sieve, and is for subsequent use, and its degree is the 60-80 order;
B. mix: get calcium carbonate 30-35%, chondroitin sulfate 15-20%, aminoglucose sulfate 20-25%, collagen 10-15%, vitamin D
30.05-0.1%, Sodium Hyaluronate 2.5-5%, starch 8-10%, dolomol 1-2% mixes, and during mixing, elder generation is vitamin D just
3Fine powder and Sodium Hyaluronate fine powder were with equivalent incremental method mixing 15-20 minute, and the Sodium Hyaluronate fine powder that adds again equal-volume (with the Sodium Hyaluronate fine powder) mixes, and makes vitamin D
3Fine powder and all transparent matter acid sodium fine powder mix; Add again collagen fine powder and starch dust mixing 15-20 minute, to mixing; Add again calcium carbonate fine powder, chondroitin sulfate fine powder, aminoglucose sulfate fine powder and mixed 30 minutes, to mixing; Added at last the dolomol mixing 5-10 minute, and to mixing, got final product.
Primary raw material of the present invention is calcium carbonate, chondroitin sulfate, aminoglucose sulfate, collagen, vitamin D
3, Sodium Hyaluronate, can increase the intake of calcium, can promote that again bone mineral deposits in bone, increase simultaneously bone tissue to the fixation of calcium, promote the absorption of the trace elements such as calcium phosphorus, avoid calcium loss, increase bone density; And selected raw material is take calcium carbonate as main, take chondroitin sulfate and aminoglucose sulfate as auxiliary, is equipped with collagen, vitamin D and Sodium Hyaluronate, and all in the safe edible dosage range, stock yard uses safety without incompatibility to each raw material consumption.
Calcium carbonate:
Calcium is the important component part that makes up bone, and it participates in growing of bone, is conducive to the balance of mineral matter in the holder and adult's bone balance.The World Health Organization (WHO) and China's osteoporosis diagnosis and treatment guide think that all calcium complement agent is the basis of osteoporosis control.The critical role of calcium in preventing and treating osteoporosis also affirmed in many researchs, emphasized its effect to bone density.Calcium and vitamin D deficiency are one of common deficiency diseases, also are to cause being grown up the main pathogenic of osteoporosis and children rachitis.When the calcium insufficiency of intake, during the vitamin D shortcoming, blood calcium reduction, for keeping calcium level, the calcium in the sclerotin can be released into blood, thereby causes that bone salts can not deposit effectively, causes the osteoid tissue hyperplasia, and the sclerotin decalcification causes osteoporosis.Calcium carbonate can replenish the calcium level of human body, and bone salts is effectively deposited, and has the function that increases bone density.A lot of reports point out that Maalox Antacid by the effect of replenishing the calcium and price comparison, is more reasonably to select.Regulation in " nutrient prime replenisher is declared and evaluated regulation (trying) ": the day dose of calcium is 250mg-1000mg.The day dose of calcium carbonate of the present invention is 1040mg, and the day dose of adjusting calcium is 416mg, belongs to the safe edible amount, with chondroitin sulfate, aminoglucose sulfate, collagen, vitamin D
3, Sodium Hyaluronate is used, and has the function of good increase bone density.
Chondroitin sulfate:
Chondroitin sulfate (chondroitin sulfate, CS) is the acidic mucopolysaccharide that is present in the humans and animals connective tissue, mainly is distributed in cartilage, bone, flesh key, sarolemma and the vascular wall.Mainly be divided into chondroitin sulfate A (CSA) (CSA) and chondroitin sulfate C (CSC) according to sulfate position difference on galactolipin, be used widely because having multiple biologically active.Chondroitin sulfate can promote cell adherence, improves intensity and the toughness of bone tissue, can bonding and the growth regulation factor and cell factor, promote the calcium deposition, and have the function that increases bone density, the day dose of chondroitin sulfate of the present invention is 560mg.Belong to safe edible dosage.With calcium carbonate, aminoglucose sulfate, collagen, vitamin D
3, Sodium Hyaluronate is used, and has the function of good increase bone density.
Aminoglucose sulfate:
Glucosamine is a kind of amino monose, is to form the basis that all connective tissues comprise the cartilage matrix glucosaminoglycan.Glucosamine is the essential material of a kind of physiology, be present in all connective tissues, content is the highest in the cartilage, Glucosamine is the synthetic glycosaminoglycan of articular cartilage and HA(hyaluronic acid) base substance of skeleton, glycosaminoglycan and HA are again the essential materials that forms proteoglycans in the joint, Glucosamine can pass through blood-synovial membrane barrier, is dispersed in the cartilage cell, and is absorbed by the cartilage cell.Glucosamine Sulphate is the sulfate of Glucosamine, at least 90% is absorbed after oral, absorbs rear 4 hours and reaches articular cartilage.With advancing age, the shortage of the Glucosamine in the human body is more and more serious, articular cartilage is constantly degenerated and wearing and tearing, and the U.S., Europe and Japanese a large amount of medical researches show: Glucosamine can help to repair and safeguard cartilage and the growth that can stimulate the cartilage cell.
Glucosamine can impel union to promote the factor-bone morphogenetic protein (BMP) secretion, and mesenchymal cell is transformed to chondroblast and Gegenbaur's cell.Bone morphogenetic protein, it is a kind of definite growth factor with induced osteogenesis activity, its main biological action is to induce undifferentiated mesenchymal cell to be differentiated to form cartilage and bone, bone morphogenetic protein is as the growth factor of unique separately mesenchymal to the differentiation of cartilage cell and Gegenbaur's cell direction, with formation and the reconstruction of sclerous tissues close relationship arranged.The basic function of bone morphogenetic protein is to induce mesenchymal cell to the differentiation of osteoblast system, and promotes osteoblast ripe.Suppress the apoptosis that the bone morphogenetic protein activity has not only limited the differentiation of osteoblast but also prevented cell.Result of study shows that bone morphogenetic protein is applied to human and animal's fractures all facilitation.Find that in experiment bone morphogenetic protein can shorten healing time and can strengthen the suppleness of healing bone.Aminoglucose sulfate can replenish the basis of articular cartilage, promotes the bone morphogenetic protein secretion, and mesenchymal cell is transformed to chondroblast and Gegenbaur's cell.Function with certain increase bone density.The day dose of aminoglucose sulfate of the present invention is 720mg, is safe edible dosage.With calcium carbonate, chondroitin sulfate, collagen, Sodium Hyaluronate, vitamin D
3Share, have the function of good increase bone density.
Collagen:
Collagen is a kind of extracellular protein, is again collagen, and it is the spiral helicine fibrous proteins that twisted into by 3 peptide chains, is the most important part of extracellular matrix, also is most important a kind of structural protein matter in the animal connective tissue.Have about 16% to be protein in human body component, collagen is the rich in protein of people's in-vivo content, accounts for more than 30% of whole body gross protein.Collagen is rich in the amino acid such as glycine that human body needs, proline, hydroxyproline, and collagen is most important part in the extracellular matrix.3 kilograms of collagens are arranged in an adult's the health approximately, and organic 70%-80% is collagen in the bone, when bone generates, at first must synthesize sufficient collagen fabric and organize skeletogenous framework.Therefore, the someone claims that collagen is the bone in the bone, plays an important role to osteoporosis.Collagen can not only improve bone toughness, also plays the important function of sticking calcium, has namely played the effect that improves bone density.The day dose of collagen of the present invention is 400mg, is safe edible dosage, is used with calcium carbonate, chondroitin sulfate, aminoglucose sulfate, has the function of good increase bone density.
Vitamin D
3:
Vitamin D
3Be a kind of liposoluble vitamin, have another name called nicotine propylhomoserin, cholecalciferol, can improve the absorption of calcium, phosphorus, make the level of plasma calcium and the blood plasma phosphorus degree that reaches capacity; Vitamin D
3Be that calcium is necessary in the intestinal mucosa absorption, bone health is played an important role.Promote bone growth and bone calcification, promote the function that tooth is sound.Vitamin D
3Can promote growth and the calcification of bone, have the function that increases bone density.Regulation in " nutrient prime replenisher is declared and evaluated regulation (trying) ": the day dose of vitamin D is 1.5-10ug, and the present invention adjusts vitamin D
3The day dose be 6ug, be used with calcium carbonate, chondroitin sulfate, aminoglucose sulfate, collagen, Sodium Hyaluronate, have the function of good increase bone density.
Sodium Hyaluronate:
Sodium Hyaluronate claims again sodium hyaluronate, being hyaluronic sodium-salt form, is a kind of straight-chain polysaccharide of HMW, is distributed widely in animal and human's body phoirocyte epimatrix, research finds that the application of 1994-2005 Sodium Hyaluronate in orthopaedics accounts for 63.2%.Sodium Hyaluronate is the main component that consists of articular cartilage and synovia, and the performance of joint physiological function is played an important role.The form that Sodium Hyaluronate is actually with sodium salt in synovia exists, and content is 1.45-3.12g/L in synovia, average 2.3g/L.The supplemented with exogenous Sodium Hyaluronate has following effect: improve the content of Sodium Hyaluronate in the knuckle synovia, assemble at cartilage surface, repair destroyed barrier, prevent that cartilage matrix from further losing; It is synthetic to increase synovial cell's hyaluronic acid, promotes chondroitin sulfate and glycoprotein synthetic, is beneficial to repair of cartilage.Toxicity test to Sodium Hyaluronate is studied, and the result shows: Sodium Hyaluronate per os acute toxicity LD50〉5000mg/kg, according to the acute oral toxicity grade scale, the true border of Sodium Hyaluronate innocuous substance.The specified volume of Sodium Hyaluronate is≤200mg/ days, day of the present invention dose be 80mg, be safe edible dosage.With calcium carbonate, chondroitin sulfate, aminoglucose sulfate, collagen, vitamin D
3Be used, have the function of good increase bone density.
The present invention's prescription is in conjunction with modern health food research achievement, and take calcium carbonate as main, calcium and bone density are closely related, and calcium is one of main component of bone, and under the adjusting of balancing, calcium is constantly mobilized from bone in vivo, constantly deposits to again bone.And calcium carbonate can replenish the calcium level of human body, and bone salts is effectively deposited, and has the function that increases bone density.Take chondroitin sulfate and aminoglucose sulfate as auxiliary, chondroitin sulfate (CS) and Glucosamine (GA) all are aminosugars compounds.The former is present in the animal cartilage tissue, and latter is one of the most basic derivative of natural chitin.Studies show that chondroitin sulfate can promote Gegenbaur's cell hyperplasia and new bone to form; Glucosamine then can impel union to promote the factor-bone morphogenetic protein (BMP) secretion, and mesenchymal cell is transformed to chondroblast and Gegenbaur's cell
[4]Be equipped with collagen, vitamin D and Sodium Hyaluronate, collagen can improve the toughness of bone and the effect of sticking calcium; Vitamin D
3Can promote the absorption of calcium in human body, and Sodium Hyaluronate is the main component that consists of articular cartilage and synovia.All in the safe edible dosage range, stock yard uses safety without incompatibility to each raw material consumption in the prescription.Be a kind of health food of good increase bone density, be fit to middle-aged and old long-term takings.
The specific embodiment
The invention will be further described below in conjunction with specific embodiment.
Equivalent increases progressively in producing medicine or food, because each component ratio differs greatly in the prescription, is difficult for mixing, therefore adopts " equivalent incremental method " effect better.Its concrete operation method is: get in a small amount component and the large component of amount of equivalent, place simultaneously mixing machinery to mix, add again with the large component of the amount of mixture equivalent and mix, so doubly amount increases until add till the large component of whole amounts.
Embodiment 1
Describe take this health food as capsule as example.
A. feed intake: the 40kg that always feeds intake, 100,000 in glue capsule.Take by weighing by weight percentage calcium carbonate 32.5%, chondroitin sulfate 17.5%, aminoglucose sulfate 22.5%, collagen 12.5%, vitamin D
30.1%, Sodium Hyaluronate 4.5%, starch 9%, dolomol 1.40%.
B. pulverize, sieve: raw material calcium carbonate, chondroitin sulfate, aminoglucose sulfate difference crushing screening with weighing up, get fine powder, for subsequent use; Collagen, Sodium Hyaluronate, starch sieve, and get fine powder, and is for subsequent use, and the granularity of calcium carbonate, chondroitin sulfate, aminoglucose sulfate, collagen, Sodium Hyaluronate, starch is 80 orders;
C. mix: with vitamin D
3Fine powder mixed 15 minutes with the equivalent incremental method with the Sodium Hyaluronate fine powder, added isopyknic Sodium Hyaluronate fine powder again and mixed, and repeated this step, until vitamin D
3Fine powder and all transparent matter acid sodium fine powder mix; Then add collagen fine powder and starch dust and mixed 15 minutes, to mixing; Add again calcium carbonate fine powder, chondroitin sulfate fine powder, aminoglucose sulfate fine powder and mixed 30 minutes, to mixing, add at last dolomol and mixed 5 minutes, to mixing, get final product;
D. can capsule: carry out encapsulatedly with automatic hard capsule filler, get capsule, the 0.40g/ grain;
Hard shell capsules net content of the present invention is the 0.4g/ grain, dose: every day 3 times, each 3.
Embodiment 2
Describe take this health food as capsule as example.
A. feed intake: the 40kg that always feeds intake, 100,000 in glue capsule.Take by weighing by weight percentage calcium carbonate 31.5%, chondroitin sulfate 16.9%, aminoglucose sulfate 23.05%, collagen 15%, vitamin D
30.05%, Sodium Hyaluronate 3.5%, starch 8%, dolomol 2%.
B. pulverize, sieve: raw material calcium carbonate, chondroitin sulfate, aminoglucose sulfate difference crushing screening with weighing up, get fine powder, for subsequent use; Collagen, Sodium Hyaluronate, starch sieve, and get fine powder, and is for subsequent use, and the granularity of calcium carbonate, chondroitin sulfate, aminoglucose sulfate, collagen, Sodium Hyaluronate, starch is 60 orders;
C. mix: with vitamin D
3Fine powder mixed 15 minutes with the equivalent incremental method with the Sodium Hyaluronate fine powder, added isopyknic Sodium Hyaluronate fine powder again and mixed, and repeated this step, until vitamin D
3Fine powder and all transparent matter acid sodium fine powder mix; Then add collagen fine powder and starch dust and mixed 15 minutes, to mixing; Add again calcium carbonate fine powder, chondroitin sulfate fine powder, aminoglucose sulfate fine powder and mixed 30 minutes, to mixing, add at last dolomol and mixed 5 minutes, to mixing, get final product;
D. can capsule: carry out encapsulatedly with automatic hard capsule filler, get capsule, the 0.40g/ grain;
Hard shell capsules net content of the present invention is the 0.4g/ grain, dose: every day 3 times, each 3.
Embodiment 3
Describe take this health food as capsule as example.
A. feed intake: the 40kg that always feeds intake, 100,000 in glue capsule.Take by weighing by weight percentage calcium carbonate 34.5%, chondroitin sulfate 18%, aminoglucose sulfate 22.5%, collagen 13.6%, vitamin D
30.1%, Sodium Hyaluronate 2 %, starch 8.3%, dolomol 1%.
B. pulverize, sieve: raw material calcium carbonate, chondroitin sulfate, aminoglucose sulfate difference crushing screening with weighing up, get fine powder, for subsequent use; Collagen, Sodium Hyaluronate, starch sieve, and get fine powder, and is for subsequent use, and the granularity of calcium carbonate, chondroitin sulfate, aminoglucose sulfate, collagen, Sodium Hyaluronate, starch is 60 orders;
C. mix: with vitamin D
3Fine powder mixed 15 minutes with the equivalent incremental method with the Sodium Hyaluronate fine powder, added isopyknic Sodium Hyaluronate fine powder again and mixed, and repeated this step, until vitamin D
3Fine powder and all transparent matter acid sodium fine powder mix; Then add collagen fine powder and starch dust and mixed 15 minutes, to mixing; Add again calcium carbonate fine powder, chondroitin sulfate fine powder, aminoglucose sulfate fine powder and mixed 30 minutes, to mixing, add at last dolomol and mixed 5 minutes, to mixing, get final product;
D. can capsule: carry out encapsulatedly with automatic hard capsule filler, get capsule, the 0.40g/ grain;
Hard shell capsules net content of the present invention is the 0.4g/ grain, dose: every day 3 times, each 3.
Result of the test:
1, acute oral toxicity test result: the maximum anti-dosage (MTD) of keeping of, male mouse female to the Kunming kind belongs to nontoxic level all greater than 20.00g/kg.bw.
2, three genetic toxicity test results: Salmonella reversion test, PCEMNR micronucleus test, mouse sperm deformity result of the test are all negative.
3,30 days feeding trial results: the ratio with 1.5%, 3.0%, 6.0% is mixed the content of product capsule qnk of the present invention in the feed and was supported 30 days to the SD rat feeding, experimental session, animal growth is good, each dosage group body weight, weightening finish, food utilization, routine blood test index, blood biochemistry index, organ weights and internal organs/body weight ratio and control group compare, there was no significant difference (P＞=0.05).Gross anatomy has no the abnormal change relevant with its sample with tissue pathology checking.Illustrate that the nursing in 30 days of this outturn sample has no obvious toxic-side effects to rat.
4, increase the bone substance density improving function test: the sample contents of the present invention with 0.3g/kg.bw, 0.6g/kg.bw, 1.8g/kg.bw dosage shows to the result of rat oral gavage after three months: 1.8g/kg.bw dosage group experiment height not is significantly higher than low calcium control group; 1.8g/kg.bw the bone density of dosage group rat femur center and distal end, femur calcium content, TC are significantly higher than low calcium control group; 0.6g/kg.bw, 1.8g/kg.bw dosage group rat takes in calcium, excrement calcium and urine calcium content and is significantly higher than low calcium control group; Calcium apparent absorption rate and Retention significantly are lower than the calcium control group, and difference has conspicuousness.The above indices of high dose group rat does not have conspicuousness with corresponding calcium carbonate control group comparing difference.The effect that outturn sample of the present invention has increases rat bone density is described.
Claims (6)
1. a health food that increases bone density is characterized in that, consists of the following composition, and counts by weight percentage: calcium carbonate 30-35%, chondroitin sulfate 15-20%, aminoglucose sulfate 20-25%, collagen 10-15%, vitamin D
30.05-0.1%, Sodium Hyaluronate 2.5-5%, starch 8-10%, dolomol 1-2%.
2. the health food of increase bone density as claimed in claim 1 is characterized in that, preferred component is calcium carbonate 32.5%, chondroitin sulfate 17.5%, aminoglucose sulfate 22.5%, collagen 12.5%, vitamin D
30.1%, Sodium Hyaluronate 4.5%, starch 9%, dolomol 1.40%.
3. the health food of increase bone density as claimed in claim 1 or 2 is characterized in that, the granularity of calcium carbonate, chondroitin sulfate, aminoglucose sulfate, collagen, Sodium Hyaluronate, starch is the 60-80 order.
4. such as the health food of claim 1,2 or 3 described increase bone densities, it is characterized in that the formulation of described health food can be particle, capsule and tablet.
5. the health food of increase bone density as claimed in claim 4 is characterized in that, the formulation of described health food is preferably capsule.
6. the preparation method of the health food of increase bone density as claimed in claim 1 comprises the steps:
A. pulverize, sieve: with calcium carbonate, chondroitin sulfate, aminoglucose sulfate difference crushing screening, for subsequent use, making its degree is the 60-80 order; Collagen, Sodium Hyaluronate, starch sieve, and is for subsequent use, and its degree is the 60-80 order;
B. mix: get calcium carbonate 30-35%, chondroitin sulfate 15-20%, aminoglucose sulfate 20-25%, collagen 10-15%, vitamin D
30.05-0.1%, Sodium Hyaluronate 2.5-5%, starch 8-10%, dolomol 1-2% mixes, during mixing, first with vitamin D
3Fine powder and Sodium Hyaluronate fine powder mix with equivalent incremental method mixing 15-20 minute, the Sodium Hyaluronate fine powder that adds again, make vitamin D
3Fine powder and all transparent matter acid sodium fine powder mix; Add again collagen fine powder and starch dust mixing 15-20 minute, to mixing; Add again calcium carbonate fine powder, chondroitin sulfate fine powder, aminoglucose sulfate fine powder and mixed 30 minutes, to mixing; Added at last the dolomol mixing 5-10 minute, and to mixing, got final product.
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| CN103211228A (en) * | 2013-04-11 | 2013-07-24 | 天津天狮生物发展有限公司 | Composition for increasing bone mineral density |
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| CN105520135A (en) * | 2015-12-20 | 2016-04-27 | 雷西云 | Healthy food with function of treating osteoporosis |
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| CN109805417A (en) * | 2019-03-01 | 2019-05-28 | 河南九九一生物科技有限公司 | A kind of health food that can increase bone density and its processing method |
| CN109965104A (en) * | 2019-03-29 | 2019-07-05 | 华熙生物科技股份有限公司 | A kind of composition and its preparation method and application containing Sodium Hyaluronate |
| CN110973636A (en) * | 2019-11-19 | 2020-04-10 | 杭州民生健康药业有限公司 | Composition containing vitamin D, preparation method thereof and application thereof in increasing bone density |
| CN115191602A (en) * | 2022-05-16 | 2022-10-18 | 张司晨 | Food formula for improving content of 'high molecular weight hyaluronic acid' in vivo |
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