CN101322551A - Combination for increasing bone density and repairing articular cartilage - Google Patents
Combination for increasing bone density and repairing articular cartilage Download PDFInfo
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- CN101322551A CN101322551A CNA2007100560249A CN200710056024A CN101322551A CN 101322551 A CN101322551 A CN 101322551A CN A2007100560249 A CNA2007100560249 A CN A2007100560249A CN 200710056024 A CN200710056024 A CN 200710056024A CN 101322551 A CN101322551 A CN 101322551A
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Abstract
A composition for increasing the bone density and repairing the articular cartilage relates to an improvement of a health care product, the range of the formula is as follows: 20 to 800 parts by weight of chondroitin sulfate, 200 to 1000 parts by weight of glucosamine and 7 to 600 parts by weight of calcium. The composition has the advantages that: the composition has the dual effects of increasing the bone density and repairing the bone joints, so the composition can not only prevent, treat and repair the articular cartilage damage, but can also enhance the bone strength, thereby being applicable to patients with arthritis of all ages, being more applicable to the middle-aged and elderly people for preventing the osteoporosis and the articular cartilage damage or the degenerative disease and having the articular cartilage regeneration repair function.
Description
Technical field
The invention belongs to food technology field, relate to a kind of improvement of health products.
Background technology
Osteoporosis is the disease so that bone density descends, risk of bone fracture increases to the skeletal system of feature.Its clinical symptoms mainly contains that the change of moving back property of sclerotin, hyperplasia, height become that short, pre-waist has a pain in the leg and bone and joint diseases, fracture etc.
People's bone the functions such as health is normally walked, heavy burden, can also be resisted certain external force except that providing.Form the master at bone at an early age with bone, calcium deposition is constantly arranged in bone, bone density improves constantly, and reaches the bone density peak value about 30 years old.Bone formation reaches balance with bone loss then, and with age growth, bone forms with the bone loss balance and broken, and bone absorbs cumulative many, and it is stable that the while health need be kept blood calcium, and the osteoclast effect increases, and calcium content of bone reduces, and bone density reduces.Therefore the osteoporosis incidence of disease increases with age growth.
The reason of osteoporosis is a lot, and is also very complicated.It is generally acknowledged, the forfeiture of postmenopausal estrogen, the unbalance and all risk factor of calcium-regulating hormone is the reason that causes osteoporosis.
Osteoporosis can be divided into three kinds of essential osteoporosis, secondary type osteoporosis and special hair style osteoporosises.The essential osteoporosis can be divided into again: PMO and senile osteoporosis are modal osteoporosises.Secondary osteoporosis mainly is because some disease causes, as hypogonadism, hyperthyroidism, hyperadrenalism or use glucocorticoid etc. for a long time, in addition, and nutritional deficiency, alcoholism, drug effect and bone tumour etc. also can cause osteoporosis.Special hair style osteoporosis is also referred to as spontaneous osteoporosis, and incidence is lower, how based on axial bone.
Along with the prolongation of human longevity, aging population gets over obviously, and osteoporosis will become large-scale global health problem.Data shows that U.S.'s patients with osteoporosis has reached 1,000 ten thousand people, and 1,800 ten thousand people that have an appointment are suspicious patients with osteoporosis.Only at US and European, the above fracture patient that is caused by osteoporosis of 2,300,000 people is arranged approximately every year, medical expense is up to more than 23,000,000,000 dollars.Estimate that European osteoporosis treatment related medical expense will increase by 1 times in 50 years.China has patients with osteoporosis (comprising that the bone amount reduces) 8,400 ten thousand people at present, accounts for 6.6% of total population.
Articular cartilage damage and the elderly's joint disease such as degenerative osteoarthropathy have important relationship.
Articular cartilage plays an important role in joint motion, and the very fine and science of its structure is to adapt to different function needs.The structure of understanding articular cartilage is significant for some problems of understanding in the osteoarthrosis pain.
Articular cartilage belongs to hyaline cartilage, and smooth surface is light blue, glossy, it is the basic framework that is made of a kind of special collagenous fibres that are called dense connective tissue, and this framework is semi-circular, similar arch goal, its bottom is tightly attached on the following sclerotin, the upper end is towards articular surface, and this structure makes articular cartilage tightly get up with synosteosis and can not fall down, when ought be under pressure simultaneously, the distortion of a little can also be arranged, play the effect of compensator or trimmer pressure.Between these fibers, be dispersed in the cartilage cell that distributing, the cartilage cell is made up of to oval or circular cell flat sample to deep layer gradually shallow-layer, and these cartilage cells keep the eubolism of articular cartilage.The main function of articular cartilage is the effect of releasing the pressure, and under pressure, cartilage is compressed; pressure relief, extensible again, be similar to the effect of cushion; just as the valve rubber between rail and the sleeper, can protect subchondral bone not to be damaged, slight damage perhaps only takes place.In addition, articular cartilage also has lubrication, and epiphysis is slided.Because elastic reaction, can restore to the original state rapidly, so the alteration of form of articular cartilage and constancy of volume.Go into the youth, this elastic reaction is stronger, and buffering effect is also good.Yet its fibre modification of the elderly, elasticity weakens, the extension ability of articular cartilage also weakens, and restorable ability also becomes not as the young people, adding the elderly's joint fluid reduces, make articular cartilage become dry, so the elderly's articular cartilage subject to damage, degenerative osteoarthropathy often takes place.
Complete articular cartilage is the basis that normal function is exercised in the joint, but articular cartilage is extremely fragile and self repair ability is low, the sick joint of decreasing often shows as the progressively deterioration that can not control, finally cause osteoarthritis (osteoarthritis, OA) the generation and the forfeiture of function of joint, this situation is especially common in big joint such as the hip that bears a heavy burden, knee.The methods of treatment that has articular cartilage defect at present both at home and abroad now is mainly based on operation:
1 arthroscope lavation art and joint debridement art
This is the most basic a kind of traditional treatment means.
2 marrow stimulating technologies (Marrow-stimulation Techniques)
Its basic principle is to utilize some biology or mechanical factor to make the primordial stem cell in the marrow be divided into cartilage and bone tissue.
3 high-order shin bones or DF osteotomy---correct easy trouble factor
Infringement is a kind of significantly easy trouble factor for the focal degenerated of articular surface because of cacomelia, thus the non-load osteotomy of normal employing correct lower limb in turn over or valgus deformity.
4 usefulness are carried out the method for biological reparation from body or allosome tissue
Transplant can repairing articular cartilage damaged and can form this fact of normal hyaline and be numerous studies confirm that from body perichondrium and periosteum.
The application of 5 artificial substratums
When adopting growth factor or cell repair articular cartilage defect, artificial substratum can play and transmit and stabilization, but the also formation of the growth of stimulation of host cell, cartilage matrix, and neonatal cell and matrix be connected to host tissue.Artificial substratum commonly used comprises bone and cartilage matrix, collagen, hyaluronic acid, cellulose, carbon fiber, hydroxyapatite, porous PLA, polytetrafluoroethylene (PTFE), polyester and other synthetic polymer, and they all can stimulate the reparation of articular surface.
6 organization engineered cartilages
Since the nineties in last century, cartilage tissue engineered appearance makes the mankind build hyaline cartilage in vivo and in vitro by artificial means, for the reparation of articular cartilage defect provides a method that has much future.
It is known before more than 200 years that articular cartilage self can't be repaired this fact, development along with medical science, multiple treatment means has applied to the reparation of articular cartilage damage, but most of curative effects are unsatisfactory, repair tissue is also many based on fibrocartilage, lacks the mechanical property and the durability of normal hyaline.Autologous tissue's material source is limited and accompany the aggressive operation more, and allosome material exists biocompatibility difference and pathophorous problem, and the prosthetic replacement is not suitable for the arthropathy damage and gentlier reaches young patient etc.
Gucosamine is a kind of amino sugar that generates naturally in the body, is the composition of carbohydrate, and it is to be formed in conjunction with glutamine (amino acid) by glucose (blood sugar), and this amino sugar is the necessary nutritional labeling of synthetic connective tissue and synovia.Connective tissue is to form ligament, the fibr tissue of tendon and cartilage, and in the skeletal musculature, the intensity of this composition often determines whether human body suffers from degenerative disorders, as osteoarthritis and rheumatoid arthritis.Gucosamine is widely used for one of nutritional labeling of constructing cartilage.Experiment shows that gucosamine promotes the metabolism of articular cartilage, stimulates body to make the protein component of the collagen-fibrous matter of support joint, and collagen is the main component of articular cartilage.Studies show that gucosamine can effectively be treated joint and connective tissue disease, comprises osteoarthritis and rheumatoid arthritis, cartilage degradation suppresses the destruction of free radical, makes impaired articular cartilage recover normal, repairs connective tissue.
Chondroitin sulfate is made up of the mucopolysaccharide strand, belongs to glycosaminoglycan, is rich in element sulphur, with gucosamine relation is arranged.Chondroitin sulfate is the main component of cartilage, constitutes the structure of cartilage, absorbs and keep the moisture of cartilage, and the cartilage nutriment is provided; And can allow other molecules pass cartilage, this is an important properties very, because cartilage does not have blood supply.Studies show that, but the chondroitin sulfate prevention of arterial is atherosis and heart attack; Can promote bone healing, in fact, most glycosaminoglycans are made up of chondroitin sulfate in the bone.Chondroitin sulfate is applicable to artery sclerosis, high cholesterol, kidney stone and osteoarthritis like the function of joint that can help to recover the arthritic.
Human body can synthesize chondroitin sulfate, but the content of chondroitin sulfate may reduce because of the influence of osteoarthritis and other forms of arthritis in the articular cartilage.Tiocondramina and chondroitin sulfate still among research, but are received good result to the synergy mechanism of osteoarthritis on reality is used.
Summary of the invention
The objective of the invention is:
A kind of a kind of composition that is used to increase bone density and repairing articular cartilage that increases bone density, enhancing and reparation cartilaginous tissue, the growth of promotion articular cartilage, improves effects such as function of joint that has is provided.
Technical scheme of the present invention is:
Its formula range is:
Chondroitin sulfate: 20-800,
Glucosamine: 200-1000,
Calcium agent: 7-600;
Above-mentioned raw materials is weight part ratio.
Its optimization formula scope is:
Chondroitin sulfate: 50-600,
Glucosamine: 250-750,
Calcium agent: 150-400;
Above-mentioned raw materials is weight part ratio.
Its optimum formula is:
Chondroitin sulfate: 100,
Glucosamine: 500,
Calcium agent: 250;
Above-mentioned raw materials is weight part ratio.
Production method:
1. after in the prescription ratio auxiliary materials such as calcium carbonate, aminoglucose hydrochloride, chondroitin sulfate raw material and microcrystalline cellulose, sweet mellow wine being prepared burden, drop in the blender, mix 30min, guarantee evenly.
2. adopt 50% ethanol water to prepare softwood as wetting agent, cross 16 mesh sieves and granulate, wet granular is in 50 ℃ of oven dryings; The whole grain of 14 mesh sieves is crossed in dry back.
3. dolomol, flavoring orange essence and minty note finishing are gone in the dried particles mixing, compressing tablet.
4. Opadry II thin film coating material is added in the entry and stirred 45 minutes, be mixed with 20% concentration, use the high-efficiency coating machine dressing, the dressing temperature is 30 ℃.
The invention has the beneficial effects as follows:
(1), the present invention is a kind of compound that contains chondroitin sulfate and Glucosamine and calcium agent, has double effects.
Chondroitin sulfate: a kind of important acid mucopolysaccharide, the main component of formation cartilage.Have the osteoblastic propagation of promotion and adhesion, strengthen bone density, promote bone healing.Repairing articular cartilage, the function of the density of cartilage in the increase bone articular cavity.
Glucosamine: be the important nutrient that forms the cartilage cell, can repair, make the articular cartilage healing, recover the smooth of surface,, reduce friction for the joint supplemental lubrication agent of sending out puckery by cartilage and surrounding soft tissue damaged or that corrode; The generation of inflammation-inhibiting, the immunocompetence of raising joint and body.An amount of Glucosamine that replenishes of the elderly can prevent the generation of Osteoarthritis, or improve symptom, and is also useful to shoulder pain and gonalgia due to scapulohumeral periarthritis, fascitis, the cervical spondylopathy.When the treatment osteoporosis, replenish Glucosamine, can also increase eburnation degree, flintiness.
Calcium carbonate: replenish the calcium agent, promote bone absorption, strengthen bone density, promote union.
Health food in the enhancing bone density of existing technical field mostly is calcium preparation, both utilized inorganic calcium, organic calcium, chelating amino acids calcium capsule etc. through the row prescription, hygiogenesis mostly is the content that increases calcium in the skeleton, bone hardness is increased, and the osamine chondroitin had both had the batching calcium carbonate of calcic, contain the main component of cartilage and cartilage cell's important nutrient again, chondroitin sulfate and Glucosamine, three's combination has synergy, the absorption of calcium can be promoted, the effect of repair of cartilage can be reached again.
In the technical field of existing identical composition: forefathers just combine chondroitin sulfate and Glucosamine and are used for the articular cartilage reparation or Glucosamine and calcium agent combined being used to prevent and treat bone density and reducing, the present invention is grouped together the three, experiment showed, to have the function that strengthens bone density and repair bone articular cartilage through function assessment.
(2) chondroitin sulfate in the present invention's prescription is a kind of mucopolysaccharide that extracts from animal cartilage, has fishy smell; Glucosamine is a kind of salt, and this product has saline taste, and mouthfeel is very bad, and the preparation that therefore contains these two kinds of compositions is all made the common sheet of swallowing.But because material content height, it is bigger to make the general sheet type of ordinary tablet, for the elderly's difficulty of swallowing, optimal formulation should be a chewable tablets, but is difficult to overcome into poor tastes such as flavor fishy smell, and the preparation that contains one or both products of the present invention does not before this all have chewable tablets, the present invention has overcome this difficulty, through experiment repeatedly, prepare a kind of taste and be fit to popular chewable tablets, the present invention has the innovation aspect taste.
(3) the present invention considers diabetic's bone joint care requirement, and the present invention prescription is designed to Sugarless type, avoids using the sugar content height, and with low cost, technological effect is sucrose, crystalline fructose etc. preferably, is applicable to consumers in general.
(4) adopt the chewable tablets formulation, chewable tablets has the following advantages
1, disintegration time weak point, good dispersing state, medicine stripping are rapid;
2, absorption is fast, bioavilability is high;
3, taking convenience can be swallowed, chew to contain and suck or with taking after the aqueous dispersion, reduce advantages such as GI burden.
(5) according to regional economy research institute of State Council a survey report in 2002, science edible health food can reduce 500,000,000 yuan of medical expenses.Have the expert to think, if the preventive medicine measure is well-done, disease can reduce half, and the life-span can prolong 10 years, and the medical consumption expenditure also can significantly reduce.So the present invention has certain social benefit and economic benefit.
The specific embodiment
Embodiment 1:
Formula for a product (chewable tablets):
Calcium carbonate 250g
Aminoglucose hydrochloride 500g
Chondroitin sulfate 100g
Microcrystalline cellulose 55g
Sweet mellow wine 50g
50% ethanol is an amount of
Dolomol 5g
Flavoring orange essence 20g
Peppermint essence 20g
Make 1000 1.0g/ sheets
Production method:
1. after in the prescription ratio auxiliary materials such as calcium carbonate, aminoglucose hydrochloride, chondroitin sulfate raw material and microcrystalline cellulose, sweet mellow wine being prepared burden, drop in the blender, mix 30min, guarantee evenly.
2. adopt 50% ethanol water to prepare softwood as wetting agent, cross 16 mesh sieves and granulate, wet granular is in 50 ℃ of oven dryings; The whole grain of 14 mesh sieves is crossed in dry back.
3. dolomol, flavoring orange essence and minty note finishing are gone in the dried particles mixing, compressing tablet.
4. Opadry II thin film coating material is added in the entry and stirred 45 minutes, be mixed with 20% concentration, use the high-efficiency coating machine dressing, the dressing temperature is 30 ℃.
Embodiment 2
Formula for a product (dispersing tablet):
Calcium carbonate 250g
Aminoglucose hydrochloride 500g
Chondroitin sulfate 100g
Microcrystalline cellulose 55g
Starch 50g
PVPP (in add type) 150g
Sodium carboxymethyl starch 85g
50% ethanol is an amount of
PVPP (adding type) 150g
Dolomol 20g
Flavoring orange essence 20g
Peppermint essence 20g
Make 1000 1.4g/ sheets
Production method:
In the prescription ratio with auxiliary material batchings such as calcium carbonate, aminoglucose hydrochloride, chondroitin sulfate raw material and microcrystalline cellulose, starch, PVPP (in add type), sodium carboxymethyl starches after, drop in the blender, mix 30min, guarantee evenly.
2. adopt 50% ethanol to prepare softwood as wetting agent, cross 16 mesh sieves and granulate, wet granular is in 50 ℃ of oven dryings; The whole grain of 14 mesh sieves is crossed in dry back.
3. PVPP (adding type), dolomol, flavoring orange essence and minty note finishing are gone in the dried particles mixing, compressing tablet.
Claims (3)
1, a kind of composition that is used to increase bone density and repairing articular cartilage, its formula range is:
Chondroitin sulfate: 20-800,
Glucosamine: 200-1000,
Calcium agent: 7-600;
Above-mentioned raw materials is weight part ratio.
2, a kind of composition that is used to increase bone density and repairing articular cartilage according to claim 1, its optimization formula scope is:
Chondroitin sulfate: 50-600,
Glucosamine: 250-750,
Calcium agent: 150-400;
Above-mentioned raw materials is weight part ratio.
3, a kind of composition that is used to increase bone density and repairing articular cartilage according to claim 1, its optimum formula is:
Chondroitin sulfate: 100,
Glucosamine: 500,
Calcium agent: 250;
Above-mentioned raw materials is weight part ratio.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100560249A CN101322551A (en) | 2007-08-31 | 2007-08-31 | Combination for increasing bone density and repairing articular cartilage |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100560249A CN101322551A (en) | 2007-08-31 | 2007-08-31 | Combination for increasing bone density and repairing articular cartilage |
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| CN101322551A true CN101322551A (en) | 2008-12-17 |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101904866A (en) * | 2010-09-07 | 2010-12-08 | 许阳 | Medicinal composition for treating osteoporosis and preparation method thereof |
| CN101647805B (en) * | 2009-09-04 | 2012-07-18 | 江苏江山制药有限公司 | Glucosamine chewable tablet used for relieving and preventing osteoarthritis and preparation method thereof |
| CN103931995A (en) * | 2014-04-23 | 2014-07-23 | 广州善元堂医药科技有限公司 | Chondroitin sulfate calcium tablet capable of increasing bone density and preparation method of chondroitin sulfate calcium tablet |
| CN104886553A (en) * | 2015-04-30 | 2015-09-09 | 威海特伦斯生物工程有限公司 | A production method of a preparation for alleviating osteoporosis and increasing bone mineral density |
| CN105105143A (en) * | 2015-07-27 | 2015-12-02 | 浙江华方生命科技有限公司 | Health-care food composition capable of increasing bone density, health-care food and preparation method |
| CN105581041A (en) * | 2015-12-12 | 2016-05-18 | 江苏雅博动物保健品有限责任公司 | High calcium emulsion for promoting pet joint repair and preparation method thereof |
| CN106262809A (en) * | 2016-07-29 | 2017-01-04 | 山东龙力生物科技股份有限公司 | A kind of bone density that strengthens alleviates the compositions of person in middle and old age's arthralgia |
| CN107048412A (en) * | 2017-04-26 | 2017-08-18 | 北京盛美诺生物技术有限公司 | A kind of masticatory pattern product containing typeⅡ Collagen |
| CN107594533A (en) * | 2017-09-12 | 2018-01-19 | 中国水产科学研究院南海水产研究所 | A kind of pinctada fucata glycosaminoglycan chewable tablets and preparation method thereof |
| CN113797310A (en) * | 2020-06-15 | 2021-12-17 | 中农极润生物科技(北京)有限公司 | Pet joint health-care preparation and preparation method and application thereof |
-
2007
- 2007-08-31 CN CNA2007100560249A patent/CN101322551A/en active Pending
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101647805B (en) * | 2009-09-04 | 2012-07-18 | 江苏江山制药有限公司 | Glucosamine chewable tablet used for relieving and preventing osteoarthritis and preparation method thereof |
| CN101904866A (en) * | 2010-09-07 | 2010-12-08 | 许阳 | Medicinal composition for treating osteoporosis and preparation method thereof |
| CN103931995A (en) * | 2014-04-23 | 2014-07-23 | 广州善元堂医药科技有限公司 | Chondroitin sulfate calcium tablet capable of increasing bone density and preparation method of chondroitin sulfate calcium tablet |
| CN104886553A (en) * | 2015-04-30 | 2015-09-09 | 威海特伦斯生物工程有限公司 | A production method of a preparation for alleviating osteoporosis and increasing bone mineral density |
| CN105105143A (en) * | 2015-07-27 | 2015-12-02 | 浙江华方生命科技有限公司 | Health-care food composition capable of increasing bone density, health-care food and preparation method |
| CN105581041A (en) * | 2015-12-12 | 2016-05-18 | 江苏雅博动物保健品有限责任公司 | High calcium emulsion for promoting pet joint repair and preparation method thereof |
| CN106262809A (en) * | 2016-07-29 | 2017-01-04 | 山东龙力生物科技股份有限公司 | A kind of bone density that strengthens alleviates the compositions of person in middle and old age's arthralgia |
| CN107048412A (en) * | 2017-04-26 | 2017-08-18 | 北京盛美诺生物技术有限公司 | A kind of masticatory pattern product containing typeⅡ Collagen |
| CN107594533A (en) * | 2017-09-12 | 2018-01-19 | 中国水产科学研究院南海水产研究所 | A kind of pinctada fucata glycosaminoglycan chewable tablets and preparation method thereof |
| CN113797310A (en) * | 2020-06-15 | 2021-12-17 | 中农极润生物科技(北京)有限公司 | Pet joint health-care preparation and preparation method and application thereof |
| CN113797310B (en) * | 2020-06-15 | 2024-04-12 | 中农极润生物科技(北京)有限公司 | Pet joint health care preparation and preparation method and application thereof |
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Open date: 20081217 |