CN101292739B - Health food having function of increasing bone substance density - Google Patents
Health food having function of increasing bone substance density Download PDFInfo
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- CN101292739B CN101292739B CN2008100282040A CN200810028204A CN101292739B CN 101292739 B CN101292739 B CN 101292739B CN 2008100282040 A CN2008100282040 A CN 2008100282040A CN 200810028204 A CN200810028204 A CN 200810028204A CN 101292739 B CN101292739 B CN 101292739B
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Abstract
The invention discloses a health-care food having the function of increasing the density of bones. The health-care food is prepared by the active components comprising radix astragali, cortex eucommiae, rhizoma drynariae, glucosamine hydrochloride, soy isoflavones and collagen protein. The health-care food of the invention is characterized by combining traditional Chinese medicinal herb features with modern medical research, thus causing various components to be prescribed reasonably and to be matched with each other for sharing and achieving the health care function by various approaches and multiple layers.
Description
Technical field
The present invention relates to a kind of bone density of increasing health care foods that has.
Background technology
Osteoporosis be one worldwide, more and more cause the health problem that people pay attention to.About 200,000,000 people in the whole world suffer from osteoporosis at present, and its incidence of disease has leapt to common disease, frequently-occurring disease the 7th.Current research shows that in fact the osteoporosis in that China is considered to the peculiar disease of the elderly always just exists in the Childhood.It is emphasized that does not especially medically also have safe and effective radical cure method at present, helps loose bone to restore to the original state, and therefore, correct understanding, early prevention seem particularly important.Along with aging population becomes clear day by day,, become healthy common disease, the frequently-occurring disease of serious harm the elderly as person in middle and old age multiple DD--osteoporosis and complication thereof.According to China part provinces and cities statistics, the senile osteoporosis disease incidence of disease more than 60 years old is about 59.89%.The annual incidence of disease because of the concurrent fracture of osteoporosis is about 9.6%, and the trend that increases is year by year arranged.
At present, the health food of the increase bone density on the market, thus most prescription is through replenishing the calcium or promoting the purpose that the absorption of calcium reaches increases bone density through endocrine; Several products of minority are also through adding Glucosamine and chondroitin sulfate; Reach the purpose of improving the joint and reach the increase bone density; The product prescription that increases bone density on the whole market is comparatively single, action pathway is also comparatively single, can not satisfy needs of people.
Summary of the invention
The object of the present invention is to provide a kind of have increase the bone density health care foods, the various composition reasonable formula of this health food, cooperate shared, through number of ways, reach the health care of enhance bone density at many levels.
Provided by the invention have increase the bone density health care foods and be prepared from the active component of following weight parts proportioning:
The Radix Astragali 20～400 barks of eucommia 5～200 rhizomes of davallia 5～150
Aminoglucose hydrochloride 10～200 isoflavones 5～200 collagens 2～100.
Preferred weight part proportioning of the active component of preparation health food of the present invention is:
The Radix Astragali 150～250 barks of eucommia 30～150 rhizomes of davallia 30～120
Aminoglucose hydrochloride 50～150 isoflavones 30～150 collagens 15～60.
Optimum weight part proportioning of the active component of preparation health food of the present invention is:
The Radix Astragali 200 barks of eucommia 75 rhizomes of davallia 60
Aminoglucose hydrochloride 100 isoflavones 75 collagens 30.
Above-mentioned have increase the bone density health care foods, through common process, can process said multiple formulation on the pharmacy, like capsule, tablet, pulvis or granule etc.
In the said components, the sweet temperature of the bark of eucommia is gone into the liver kidney,, tonifies the liver and kidney the effect of strong muscles and bones for controlling the key medicine of pain in the back; The sweet temperature of the rhizome of davallia is gone into the liver kidney, and warming and invigorating kidney Yang is arranged, and strengthens muscles and bones, the merit of the continuous muscle of invigorating blood circulation." the kidney being the origin of congenital constitution " so two medicines share, can be mended the deficient of " congenital " altogether.Right the congenital foundation depends on the cultivation of the day after tomorrow, and " the spleen being the foundation of acquired constitution " is so add the Radix Astragali again just, air making-up and spleen enlivening, the day after tomorrow and nourish congenital of supplementing nutrition.Full side's reinforce spleen and kidney together, subsidize the congenital day after tomorrow each other, receive altogether and tonify the liver and kidney strong muscles and bones, the continuous muscle of invigorating blood circulation, the effect that replenishes qi to invigorate the spleen.
Isoflavones is the one type of secondary metabolite that forms in the soybeans they grow, is a kind of in the biological flavone, because it and estrogenic molecular structure are closely similar, its chemical constitution and estrogen are quite similar, have weak estrogen-like action.Research shows, the metabolism of isoflavones adjustable bone prevents that mineral matter such as calcium runs off from bone, promote bone to form, thereby improve bone density.
Glucosamine is the main component of lubricated connective tissue between the human joint, is the viscosity of repairing articular cartilage, raising knuckle synovia and the essential material that improves the metabolism of articular cartilage.In addition, the Glucosamine pain that arthritis causes of still can releiving has tangible anti-inflammatory analgesic action, and can not cause side effect.Now, natural Glucosamine just begins to become the most popular joint maintenance healthy food of American-European healthy food industry.
Collagen is suitable as the protein building (generating material like connective tissues such as sclerotin, articular cartilage, muscle, skins) of cartilaginous tissue and connective tissue, and capacity is replenished the high-quality collagen in good time, can improve the toughness and increase bone density of bone; Simultaneously effective repairing articular cartilage prevents articular cartilage attenuation, wearing and tearing.
The characteristics of health food of the present invention are to be primary raw material with the Radix Astragali, the bark of eucommia, three kinds of Chinese herbal medicines of the rhizome of davallia and aminoglucose hydrochloride, isoflavones, collagen; Make various composition reasonable formula, cooperate shared, through number of ways, reach the health care of enhance bone density at many levels.
Through the specific embodiment and pharmacodynamic study result the present invention is described further below.
The specific embodiment
The present invention will be described to enumerate a part of specific embodiment below, is necessary to be pointed out that at this following specific embodiment only is used for the present invention is described further, and do not represent the restriction to protection domain of the present invention.Some nonessential modifications that other people make according to the present invention and adjustment still belong to protection scope of the present invention.
Embodiment 1
The embodiment of the invention 1 provides has increases the bone density health care foods and is prepared from the active component of following weight proportioning: Radix Astragali 40kg, bark of eucommia 150kg, rhizome of davallia 10kg, aminoglucose hydrochloride 10kg, isoflavones 10kg, collagen 80kg.
Embodiment 2
The embodiment of the invention 2 provides has increases the bone density health care foods and is prepared from the active component of following weight proportioning: Radix Astragali 90kg, bark of eucommia 110kg, rhizome of davallia 50kg, aminoglucose hydrochloride 60kg, isoflavones 50kg, collagen 60kg.
Embodiment 3
The embodiment of the invention 3 provides has increases the bone density health care foods and is prepared from the active component of following weight proportioning: Radix Astragali 150kg, bark of eucommia 70kg, rhizome of davallia 80kg, aminoglucose hydrochloride 100kg, isoflavones 80kg, collagen 40kg.
Embodiment 4
The embodiment of the invention 4 provides has increases the bone density health care foods and is prepared from the active component of following weight proportioning: Radix Astragali 200kg, bark of eucommia 30kg, rhizome of davallia 100kg, aminoglucose hydrochloride 140kg, isoflavones 100kg, collagen 20kg.
Embodiment 5
The embodiment of the invention 5 provides has increases the bone density health care foods and is prepared from the active component of following weight proportioning: Radix Astragali 400kg, bark of eucommia 10kg, rhizome of davallia 150kg, aminoglucose hydrochloride 200kg, isoflavones 200kg, collagen 10kg.
Embodiment 6
The embodiment of the invention 6 provides has increases the bone density health care foods and is prepared from the active component of following weight proportioning: Radix Astragali 200kg, bark of eucommia 75kg, rhizome of davallia 60kg, aminoglucose hydrochloride 100kg, isoflavones 75kg, collagen 30kg.
Among the above embodiment, isoflavones is the commercial goods, and specification can be isoflavone content >=20%, isoflavone content >=40% etc.Through common process, can process said multiple formulation on the pharmacy, like capsule, tablet, pulvis or granule etc.
Pharmacodynamic study
The applicant uses the composition proportioning of the health food that is provided by the foregoing description 6, has the bone density of increasing health care foods and has carried out the effect confirmatory experiment through common process is prepared, and experimental result is following:
1. experimental unit
Medicine Molecular Biology Lab of life science institute of Zhongshan University.
2. experiment purpose
These article of research have the bone density of increasing effect.
3. experiment material
3.1 experiment medicine
Health food of the present invention: increase bone density health products (tablet), lot number is provided: 070917 by Southern Co. LiJinJi Co., Ltd; Usage: each 1.2g, every day 2 times.
3.2 experiment reagent
Benzylpenicillin sodium for injection, Huabei Pharmaceutic Co., Ltd produces, lot number: Y0703102;
3.3 detecting instrument:
The BS110S electronic balance, Beijing Sai Duolisi balance Co., Ltd produces; DiscoveryA type dual-energy x-ray, U.S. Hologic company produces, Nuclear Medicine Dept of Guangdong People's Hospital bone density chamber; Thermo Xseries ICP-MS (icp ms), Guangzhou Center for Disease Control physics and chemistry chamber; ECOM-F6124 type semi-automatic biochemical analyzer, German effendorf company produces.
3.4 animal used as test
SPF level SD rat, female, animal used as test credit number: SCXK (Guangdong) 2003-0002 is provided by Guangdong Medical Lab Animal Center; The quality certification number: 2007A003.
3.6 raising condition
SPF level SD rat feeding is in Zhongshan University's school of life and health sciences Chinese medicine and marine drug laboratory SPF level laboratory animal room, the zoopery environmental facility quality certification number: GB14925-2001, and word 2004C009 checks and affirm in Guangdong; 25 ± 1 ℃ of indoor maintenances are freely drunk water, are taken food, and adopt 12h:12h to be interrupted illumination round the clock; Change water weekly 3 times; Change bedding and padding 2 times, the water material is sufficient, and SPF level feed originates from Guangdong Medical Lab Animal Center.
3.7 experimental result statistical procedures
Experimental data adopts Microsoft Excel 2003 to carry out statistical procedures, and the result representes with x ± s, and carries out TTEST and analyze the conspicuousness of t value method comparative group differences.
4. experimental technique and result
4.1 increase the bone density experimental technique
Choosing 100 of healthy SD rats, is female entirely, body weight 180-220g, and animal comes the back about one week of quarantine; Carrying out modeling then handles.Rat is through lumbar injection chloraldurate 10%, presses the anesthesia of 0.3g/kg body weight, fixing back, abdomen position in ventrimeson apart from introitus 3--4cm place unhairing, use the tincture of iodine and alcohol disinfecting respectively; Treat that dried slightly back cuts skin and the about 2--3cm of abdominal muscle, it is thus clear that the otch visual field is white adipose, after pushing fat deposit aside and finding the uterus; Gently a side cornua uteri is pulled out, terminal visible at it by the ovary of cellulite parcel, fractionation of fatty group; Just can see the ovary of pink or yellowish red color, clamp ovary, then fallopian tubal under the ovary (comprising fat) used the silk thread ligation with haemostatic clamp; Wipe out ovary (whether inspection wipes out fully), take advantage of a situation cornua uteri is sent back in the abdominal cavity, wipe out other side ovary with method.After abdominal muscle and skin layering are sewed up, sterilization once more.After hindlimb muscle injection 4000U/kg penicillin, antibiotic was handled 3 days continuously.Behind the removal ovary 3 days, rat is divided into groups at random, be respectively normal control group, model control group, the basic, normal, high dose groups of increase bone density article; Every group of 15-16 only.Respectively each group rat is weighed, number, and carry out administration by the dosage in the table 1.
Rat is write down body weight weekly once, and by body weight value adjustment dosage.This model experiment time is 4 months.
After the modeling 4 months, each group rat is all measured BMD value, femur weight in wet base, wet density, the dry density of bone density.
4.2 observation index
4.2.1 bone densitometry
The dual-energy x-ray method is measured neck of femur, femur distal end and femur mid point with borne densitometers.At first the femur to rat the same side scans, and chooses femoral head to kneed position; Carry out data analysis then: measure the femur total length earlier, confirm mid point again, survey the bone density BMD value in the 8mm*11mm scope; Duplicate equal area then in neck of femur and femoral far heart end position, record BMD value.
4.2.2 femur weight in wet base, wet density, dry density are measured
Take out the right side femur, pick the connective tissue that adheres to the greatest extent, after weighing on the assay balance, measure volume on the micro-stereometry device, and calculate wet density (weight in wet base/volume).In 105 ℃ of baking ovens, dry to constant weight, weigh, calculate dry density (dry weight/volume).
4.3 experimental result
Can get by table 1 experimental result; The bone density of neck of femur of model control group rat and femur distal end obviously reduces, with the same period normal control group compare, have significant difference (P＜0.001); Prompting is owing to directly cause the estrogenic reduction of animal used as test behind the removal ovary; Make the bone metabolism be negative balance-bone and absorb enhancing, the bone amount is lost gradually, and osteoporosis model is successful on the whole.The middle and high dose groups that increases the bone density health products all can increase the BMD value of neck of femur and the femur distal end of removal ovary rat significantly; Wherein increase the bone density health products middle dose groups the femoral neck BMD value and increase bone density health products high dose group neck of femur the BMD value with the same period model control group compare; Have significant difference (P＜0.01), middle and high dose groups has improved 14.96% and 14.46% than the bone density of model group respectively.In sum: the middle and high dose groups of increase bone density health products has effect preferably to the bone density increase of removal ovary rat.
Table 1 increases the bone density health products influences result
to removal ovary rat bone density BMD
Annotate: with the model control group comparison same period
*P＜0.05;
*P＜0.01;
* *P＜0.001.
Visible by table 2 experimental result; Femur wet density of model control group rat and dry density value all obviously reduce; With the same period normal control group compare, have significant difference (P＜0.05, P＜0.001); And the body weight of model control group rat obviously increases, with the same period normal control group compare and have significant difference (P＜0.01); When the weight of femur increases (weight in wet base and dry weight), volume increases and is in the state of estrogen deficiency; The specific variations of femur wet density and dry density in the table 2 occurred, explained thus to have formed typical osteoporosis model when the removal ovary rat reaches 4 months.The middle and high dose groups that increases the bone density health products can increase femur wet density and the dry density of removal ovary rat; Wherein increase the bone density health products high dose group the femoral shaft density value with the same period model control group compare; Has significant difference (P＜0.001, P＜0.01); In sum, increase bone density health products high dose has effect preferably to the bone density increase of removal ovary rat.
Table 2 given the test agent influences result
to removal ovary rat body weight, bone wet density and dry density
| Group | Dosage (mg/kg) | Number of animals (n) | The 16th all body weight (g) | Femur weight in wet base (g) |
| The normal control group | Equal-volume | 10 | 300.1±37.7 ** | 0.8021±0.0850 * |
| Model control group | Equal-volume | 14 | 345.9±34.5 | 0.8750±0.0744 |
[0072]
| Increase bone density article (low) | 200 | 14 | 346.6 ± 40.5 | 0.8468 ± 0.0860 |
| Increase bone density article (in) | 400 | 14 | 358.7 ± 33.3 | 0.8693 ± 0.0629 |
| Increase bone density article (height) | 800 | 14 | 353.3 ± 29.9 | 0.8799 ± 0.0508 |
| Group | Femur volume (ml) | Femur dry weight (g) | Femur wet density (g/ml) | Femoral shaft density (g/ml) |
| The normal control group | 0.48±0.05 ** | 0.5836±0.0564 | 1.66±0.13 * | 1.21±0.08 *** |
| Model control group | 0.56±0.05 | 0.6112±0.0761 | 1.55±0.09 | 1.08±0.08 |
| Increase bone density article (low) | 0.57±0.05 | 0.5952±0.0580 | 1.48±0.09 * | 1.04±0.07 |
| Increase bone density article (in) | 0.56±0.04 | 0.6412±0.0596 | 1.55±0.08 | 1.14±0.07 |
| Increase bone density article (height) | 0.55±0.04 | 0.6517±0.0436 | 1.59±0.09 | 1.18±0.05 *** |
Annotate: with the model control group comparison same period
*P＜0.05;
*P＜0.01;
* *P＜0.001.
5. brief summary
This experimental result shows that health food of the present invention has the bone density of increasing health function.
Claims (4)
1. one kind has the bone density of increasing health care foods, it is characterized in that the active component of this health food and weight portion proportioning thereof are:
The Radix Astragali 20～400 barks of eucommia 5～200 rhizomes of davallia 5～150
Aminoglucose hydrochloride 10～200 isoflavones 5～200 collagens 2～100.
2. according to claim 1 have increase the bone density health care foods, wherein the weight portion proportioning of each active component is:
The Radix Astragali 150～250 barks of eucommia 30～150 rhizomes of davallia 30～120
Aminoglucose hydrochloride 50～150 isoflavones 30～150 collagens 15～60.
3. according to claim 1 have increase the bone density health care foods, wherein the weight portion proportioning of each active component is:
The Radix Astragali 200 barks of eucommia 75 rhizomes of davallia 60
Aminoglucose hydrochloride 100 isoflavones 75 collagens 30.
According to claim 1,2 or 3 described have increase the bone density health care foods, the formulation that it is characterized in that described health food is capsule, tablet, pulvis or granule.
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102813202A (en) * | 2012-09-06 | 2012-12-12 | 苏州谷力生物科技有限公司 | Health-care product for preventing osteoporosis |
| CN103960676A (en) * | 2014-05-09 | 2014-08-06 | 安徽源和堂药业股份有限公司 | Eucommia ulmoides granule and preparation method thereof |
| CN104922199A (en) * | 2015-07-14 | 2015-09-23 | 无限极（中国）有限公司 | Bone and joint protection composition and application thereof |
| CN106420905A (en) * | 2016-11-30 | 2017-02-22 | 高振达 | Capsule for increasing bone density and preparation method of capsules |
| CN107581608A (en) * | 2017-09-22 | 2018-01-16 | 张丽艳 | A kind of capsule preparations for increasing bone density and preparation method thereof |
| CN110384229A (en) * | 2018-04-18 | 2019-10-29 | 雅安迅康药业有限公司 | A kind of health-care food composition and application thereof increasing bone density |
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| CN1554383A (en) * | 2003-12-20 | 2004-12-15 | 柳州市益神寿保健品有限责任公司 | Composition for treating osteoporosis |
| CN1559589A (en) * | 2004-03-10 | 2005-01-05 | 山东师范大学 | Medicinal liquid for treating osteoporosis and its preparation method |
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| CN1554383A (en) * | 2003-12-20 | 2004-12-15 | 柳州市益神寿保健品有限责任公司 | Composition for treating osteoporosis |
| CN1559589A (en) * | 2004-03-10 | 2005-01-05 | 山东师范大学 | Medicinal liquid for treating osteoporosis and its preparation method |
Non-Patent Citations (2)
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